@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMM6: (2017-11-09 )
MTNLNLNINQNDVELIPENHPESQEPVVGAEILIEQLYKFYGEVKVLEDLNLHIQPGEFLAIVGRSGCGKSTLLRLIAQLEKASFGEIKFKSARHLREGITNDDIRVMFQDPRLLPWRNILQNVQLGLPKSQHALAEELLEKVGLKEKAGQWPSQLSGGQRQRTALARALSHTPRILLLDEPLGALDALTRLEMQSLIERLWKEQGFTAILVTHDVSEAVQLADRIILLDKGQIAQSFQVNLPRPRKKSITFAQLEQQVLDAVLAT
Atome Classification :
(59 SA)
.........10........20........30........40........50........60........70........80.......-------.90......----..100-----..-----..-----...110--.......120.....------..-------------130-----.-------..-------....------.140..-------.....--150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
N
L
N
L
N
INQN
D
V
E
LIPENHPESQEPVV
G
A
E
I
L
I
E
Q
L
Y
K
F
YGE
V
K
V
L
EDL
N
L
H
IQPG
E
F
L
A
I
VGRSGC
G
K
S
T
L
L
R
L
I
A
Q
L
E
KASFG
E
I
-------
K
F
K
S
A
R
H
L
R
----EGITN-----D
D
-----
I
R
-----
V
M
FQDP--RL
L
P
W
R
N
I
L
Q
N
V
QLG------LP-------------
K
S
------
Q
-------
H
A
-------
L
A
E
E
------
L
L
E
KVG-------
L
K
E
KA--GQW
P
S
QLSG
G
Q
R
Q
R
T
A
L
A
R
A
LSHT
P
R
I
L
L
LDEP
L
G
A
L
D
A
L
T
R
L
E
M
Q
S
L
I
E
R
L
W
K
EQG
F
T
A
I
L
V
TH
D
V
S
E
A
V
Q
L
A
D
R
I
I
L
L
DKGQIA
Q
S
F
QVNLPRPRKKSI
T
F
A
Q
L
E
Q
Q
V
L
D
A
V
LAT
23
PsiBlast_CBE
85.84
41%
-70
- C1 -
-
3PUZ
1
MALK_ECOLI
B:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
QVAEVLQ
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
19
PsiBlast_PDB
84.95
41%
-72
- C1 -
-
4KI0
3
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
22
PsiBlast_CBE
84.83
41%
-71
- C1 -
-
3RLF
2
MALK_ECOLI
B:
[2-215]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
QVAEVLQ
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
155
HHSearch
84.77
40%
-38
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[3-220]
------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
K
-------------
L
A
GAK
K
E
V
I
-------
N
Q
-------
R
V
N
Q
------
V
A
E
V
L
Q
-------
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
------------------------
156
HHSearch
84.63
40%
-38
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-220]
------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
K
-------------
L
A
GAK
K
E
V
I
-------
N
Q
-------
R
V
N
Q
------
V
A
E
V
L
Q
-------
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
------------------------
16
PsiBlast_PDB
84.20
41%
-70
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
14
PsiBlast_PDB
84.11
41%
-73
- C1 -
-
3PUW
2
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
36
PsiBlast_CBE
84.04
41%
-69
- C1 -
-
2R6G
2
MALK_ECOLI (first)
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
15
PsiBlast_PDB
84.04
41%
-71
- C1 -
-
3PUX
2
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
13
PsiBlast_PDB
83.85
41%
-69
- C1 -
-
3PUV
2
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
35
PsiBlast_CBE
83.51
41%
-76
- C1 -
-
2R6G
2
MALK_ECOLI (first)
B:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
QVAEVLQ
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
18
PsiBlast_PDB
83.50
41%
-71
- C1 -
-
4KHZ
-
?
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
30
PsiBlast_CBE
83.29
41%
-60
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
10
PsiBlast_PDB
82.51
41%
-70
- C1 -
-
3PUY
2
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
11
PsiBlast_PDB
82.49
41%
-70
- C1 -
-
3PUZ
1
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
24
PsiBlast_CBE
82.42
41%
-71
- C1 -
-
3PUY
2
MALK_ECOLI
B:
[2-224]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
25
PsiBlast_CBE
82.04
41%
-66
- C1 -
-
3PUX
2
MALK_ECOLI
B:
[2-224]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
27
PsiBlast_CBE
81.93
41%
-67
- C1 -
-
3PUV
2
MALK_ECOLI
B:
[2-224]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
21
PsiBlast_CBE
81.69
41%
-69
- C1 -
-
4KI0
2
MALK_ECOLI
B:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
QVAEVLQ
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
17
PsiBlast_PDB
81.69
41%
-61
- C1 -
-
4JBW
-
MALK_ECOLI
A:
[2-214]
-----------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
-------
F
I
G
E
K
R
M
N
D
----
T
P
P
A
E
-----
R
G
-----
V
G
-----
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
------
L
--------------
K
L
------
A
-------
G
A
-------
K
K
E
V
------
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
--
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
------------------------------
57
PsiBlast_CBE
80.31
39%
-49
- C1 -
-
2OLJ
3
?
A:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
L
N
K
V
R
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWP
R
E
K
A
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
52
PsiBlast_CBE
79.16
39%
-49
- C1 -
-
2OLK
1
?
D:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
44
PsiBlast_CBE
78.74
39%
-46
- C1 -
-
3C41
2
?
K:
[4-218]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
43
PsiBlast_CBE
78.57
39%
-48
- C1 -
-
3C4J
2
?
A:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
L
N
K
V
R
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWP
R
E
K
A
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
41
PsiBlast_CBE
78.52
40%
-32
- C1 -
-
4U00
1
?
A:
[5-218]
-------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
DGL--
S
V
K
D
D
R
A
L
R
----
E
--
I
R
-----
R
E
-----
V
G
-----
M
V
F
Q
Q
F
--
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
RR
W
P
-------------
R
E
------
K
A
------
E
K
-------
K
A
L
E
------
L
L
E
R
V
G
-------
I
L
D
Q
A
--
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
------------------------------
42
PsiBlast_CBE
78.10
39%
-47
- C1 -
-
3C4J
2
?
B:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
54
PsiBlast_CBE
78.09
39%
-51
- C1 -
-
2OLK
2
?
B:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
45
PsiBlast_CBE
78.09
39%
-47
- C1 -
-
3C41
2
?
J:
[4-218]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
47
PsiBlast_CBE
77.84
39%
-47
- C1 -
-
2Q0H
3
?
A:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
L
N
K
V
R
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWP
R
E
K
A
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
53
PsiBlast_CBE
77.27
39%
-53
- C1 -
-
2OLK
1
?
C:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
159
HHSearch
77.13
37%
-24
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-226]
-----------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
-------
S
L
S
G
K
T
I
F
S
KNTN
L
P
V
R
E
-----
R
R
-----
L
G
-----
Y
L
V
Q
E
G
--
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
------
L
G
-------------
N
G
KGRTAQ
E
-------
R
Q
-------
R
I
E
A
------
M
L
E
L
T
G
-------
I
S
E
L
A
--
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
-----------------------
55
PsiBlast_CBE
77.05
39%
-49
- C1 -
-
2OLK
1
?
A:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
L
N
K
V
R
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWP
R
E
K
A
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
46
PsiBlast_CBE
76.00
39%
-46
- C1 -
-
2Q0H
3
?
B:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
L
N
K
V
R
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWP
R
E
K
A
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
56
PsiBlast_CBE
75.57
39%
-42
- C1 -
-
2OLJ
2
?
B:
[25-239]
-------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
-------
I
I
D
G
I
-
N
L
K
----
A
K
D
T
N
LNKVR
E
E
-----
V
G
-----
M
V
F
Q
R
F
--
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
------
P
M
-------------
K
V
------
R
KWPREKA
E
A
-------
K
A
M
E
------
L
L
D
K
V
G
-------
L
K
D
K
A
--
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
------------------------------
62
PsiBlast_CBE
70.32
37%
-44
- C1 -
-
4YMU
1
?
J:
[2-216]
-------------------------------
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
--------
F
I
D
G
V
K
I
N
----
N
G
K
V
N
-----
I
N
KVRQK
V
G
-----
M
V
F
Q
H
F
--
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
-------------
K
V
------
K
-------
K
M
NKKEAEE
L
A
V
D
------
L
L
A
K
V
G
-------
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------
63
PsiBlast_CBE
70.22
37%
-44
- C1 -
-
4YMU
1
?
A:
[2-216]
-------------------------------
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
--------
F
I
D
G
V
K
I
N
----
N
G
K
V
N
-----
I
N
K
V
R
Q
K
V
G
-----
M
V
F
Q
H
F
--
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
-------------
K
V
------
K
-------
K
M
N
K
K
E
A
E
E
L
A
V
D
------
L
L
A
K
V
G
-------
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------
68
PsiBlast_CBE
69.52
38%
-18
- C1 -
-
3FVQ
2
FBPC_NEIG1
B:
[3-220]
-----------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
-------
S
L
-
S
G
K
T
I
F
----
S
K
N
T
N
-----
L
P
-----
V
R
ERRLG
Y
L
V
Q
E
G
--
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
------
L
G
-------------
N
G
------
K
-------
G
R
-------
T
A
Q
E
RQRIEA
M
L
E
L
T
G
-------
I
S
E
L
A
--
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
-----------------------------
69
PsiBlast_CBE
67.38
38%
-14
- C1 -
-
3FVQ
2
FBPC_NEIG1
A:
[3-225]
-----------------------------
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
-------
S
L
-
S
G
K
T
I
F
----
S
K
N
T
N
-----
L
P
-----
V
R
ERR
L
G
Y
L
V
Q
E
G
--
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
------
L
G
-------------
N
G
------
K
-------
G
R
-------
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
-------
I
S
E
L
A
--
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
-----------------------------
61
PsiBlast_CBE
67.25
37%
-43
- C1 -
-
4YMV
1
?
A:
[2-216]
-------------------------------
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
--------
F
I
D
G
V
K
I
N
----
N
G
K
V
N
-----
I
N
K
V
R
Q
K
V
G
-----
M
V
F
Q
H
F
--
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
-------------
K
V
------
K
-------
K
M
N
K
K
E
A
E
E
L
A
V
D
------
L
L
A
K
V
G
-------
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------
60
PsiBlast_CBE
67.15
37%
-46
- C1 -
-
4YMV
1
?
J:
[2-216]
-------------------------------
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
--------
F
I
D
G
V
K
I
N
----
N
G
K
V
N
-----
I
N
KVRQK
V
G
-----
M
V
F
Q
H
F
--
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
------
P
V
-------------
K
V
------
K
-------
K
M
NKKEAEE
L
A
V
D
------
L
L
A
K
V
G
-------
L
L
D
K
K
--
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
------------------------------
95
PsiBlast_CBE
63.20
33%
-24
- C1 -
-
4HLU
1
ECFA2_THEMA
B:
[21-217]
------------------------------------------
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-------
L
Y
D
G
E
R
K
K
G
----
Y
E
I
R
R
-----
N
------
I
G
-----
I
A
F
Q
Y
P
ED
Q
F
F
A
E
R
-
V
F
D
E
V
A
F
A
------
V
K
NFYPD--------
R
D
------
P
-------
V
P
-------
L
V
K
K
------
A
M
E
F
V
G
-------
L
D
F
D
S
FK
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
-
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
---------------------------------
96
PsiBlast_CBE
62.56
33%
-24
- C1 -
-
4HLU
1
ECFA2_THEMA
A:
[21-217]
------------------------------------------
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-------
L
Y
D
G
E
R
K
K
G
----
Y
E
I
R
R
-----
N
------
I
G
-----
I
A
F
Q
Y
P
ED
Q
F
F
A
E
R
-
V
F
D
E
V
A
F
A
------
V
K
NFYPD--------
R
D
------
P
-------
V
P
-------
L
V
K
K
------
A
M
E
F
V
G
-------
L
D
F
D
S
FK
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
-
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
---------------------------------
97
PsiBlast_CBE
60.49
33%
-17
- C1 -
-
4ZIR
2
ECFA2_THEMA
A:
[20-216]
------------------------------------------
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-------
L
Y
D
G
E
--
K
G
----
Y
E
I
R
R
-----
N
------
I
G
-----
I
A
F
Q
Y
P
ED
Q
F
F
A
E
R
-
V
F
D
E
V
A
F
A
------
V
K
NFYPD--------
R
D
------
P
-------
V
P
-------
L
V
K
K
------
A
M
E
F
V
G
-------
L
D
F
D
S
FK
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
-
W
K
T
L
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
---------------------------------
98
PsiBlast_CBE
55.38
35%
-27
- C1 -
-
2FF7
1
A:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
100
PsiBlast_CBE
53.71
35%
-30
- C1 -
-
2PMK
1
A:
[20-219]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
102
PsiBlast_CBE
51.98
34%
-28
- C1 -
-
3B5J
1
A:
[20-219]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
116
PsiBlast_CBE
51.40
34%
-21
- C1 -
-
2FFA
2
A:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
119
PsiBlast_CBE
51.21
34%
1
- C1 -
-
1XEF
2
HLYBP_ECOLX
B:
[18-217]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
112
PsiBlast_CBE
50.94
34%
-2
- C1 -
-
2FGJ
2
D:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
120
PsiBlast_CBE
50.82
34%
-1
- C1 -
-
1XEF
2
HLYBP_ECOLX
A:
[18-217]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
117
PsiBlast_CBE
50.49
34%
-1
- C1 -
-
1XEF
2
D:
[18-217]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
103
PsiBlast_CBE
50.31
34%
-9
- C1 -
-
2FGK
2
D:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
106
PsiBlast_CBE
49.93
34%
-10
- C1 -
-
2FGK
2
HLYBP_ECOLX
A:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
114
PsiBlast_CBE
49.90
34%
-7
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
115
PsiBlast_CBE
49.67
34%
-7
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
DGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMS
V
E
K
V
I
Y
A
A
K
L
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
118
PsiBlast_CBE
49.02
34%
-4
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[18-217]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
105
PsiBlast_CBE
47.82
34%
-5
- C1 -
-
2FGK
2
HLYBP_ECOLX
B:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
104
PsiBlast_CBE
47.58
34%
-13
- C1 -
-
2FGK
2
HLYBP_ECOLX
C:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------
113
PsiBlast_CBE
47.56
34%
-2
- C1 -
-
2FGJ
2
HLYBP_ECOLX
C:
[24-223]
---------------------------------------------
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
LIDGHDL
A
L
A
D
P
N
W
L
R
----
R
----------
Q
-----
V
G
-----
V
V
L
Q
D
N
--
V
L
L
N
-
R
S
I
I
D
N
I
S
L
A
------
N
P
GMSVEKVIYAAKL
A
G
------
A
-------
H
D
-------
F
I
S
E
------
L
R
E
--
G
-------
Y
N
T
I
V
--
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
-
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
------------------------------