@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMT9: (2017-11-10 )
MALRHFLTLRDLSTLELNRILERASELKKMQQSNKVYQPFVGKVLGMIFEKSSTRTRISFEAGINQFGGSAIFLSPRDTQLGRGEPIEDSARVISSMLDIVMIRTFGHDIVERFASYSKVPVINGLTDDHHPCQLLADLQTYIEYRGSIEGKTVAWIGDGNNMCNSYIEAAHMMGFKLKIASPKGYEPKPEFLAEFGHCVELFDNAEDAAVNADLIVTDVWASMGQEEEQKLREKAFADFQVNEKLMGLAHPDCLFMHCLPAHRGEEISETMLDHKNAVVWDEAENRLHAQKALMEFLLNENLKKA
Atome Classification :
(46 SA)
.........10........20........30..-......40-.-.......50........60........70........80........90........100.......110.......120.......130.......140...---..---..150.-----..-----.....160-........170.......180.......190-----...-------.-------.-------.-------...200----.....--------..210-........220----.......-.230.....-...240......-.-250.......260------------------.-----------------......270.......280.......290.......300....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
L
R
H
F
L
T
L
RD
L
S
T
L
E
L
N
R
I
L
E
R
A
S
E
L
K
K
M
Q
QS-NKV
Y
Q
P
F
V
-
G
-
K
V
L
G
M
I
FEKSST
R
T
R
I
S
F
EAGINQFGG
S
A
I
F
LSPRDTQLGRGEPI
E
D
S
A
R
V
I
S
S
M
L
D
I
V
M
I
R
T
F
G
H
D
I
V
E
R
F
ASYSKV
P
V
INGLTDDH
H
P
C
Q
L
L
A
D
L
Q
T
Y
I
E
Y
---RG---SIEG-
K
-----
T
V
-----
A
W
IGDG-
N
-
N
M
C
N
S
Y
I
E
A
A
H
MM
G
F
K
L
K
IASPKGYEP
K
P
-------
E
F
L
-------
A
-------
E
-------
F
-------
G
H
C
V
E
L
----FDNAE--------DAAV--NA
D
L
I
V
T
D
V
W
-----
A
SMG
Q
E
E
-
E
Q
-
K
L
R
E
K
A-FADFQV
N
E
K
L
MG-L-AHP
D
C
L
F
M
HCLPA------------------H-----------------RG
E
E
I
S
E
T
M
L
DHKN
A
V
V
WDEAEN
R
L
H
A
Q
K
A
L
M
E
F
L
L
NENLKKA
1
PsiBlast_PDB
91.44
56%
-94
- C10 -
-
4F2G
1
?
A:
[6-303]
--
I
R
H
Y
L
Q
F
K
D
F
S
L
E
D
Y
E
Y
V
L
E
R
T
G
I
L
K
R
K
F
K
N
-
Y
E
T
Y
H
P
L
H
-
D
-
R
T
L
A
M
I
F
E
K
S
S
T
R
T
R
L
S
F
E
A
G
I
F
Q
L
G
G
H
A
V
F
M
S
T
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T
Q
L
G
R
G
E
P
V
E
D
S
A
Q
V
I
S
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D
I
I
M
I
R
T
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V
P
V
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N
G
L
T
N
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Y
H
P
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L
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D
I
F
T
Y
Y
E
H
---
R
G
---
P
I
R
G
-
K
-----
T
V
-----
A
W
V
G
D
A
-
N
-
N
M
L
Y
T
W
I
Q
A
A
R
I
L
D
F
K
L
Q
L
S
T
P
P
G
Y
A
L
D
A
-------
K
L
V
D------
A
-------
E
-------
S
-------
A
P
F
Y
Q
V
----
F
D
D
P
N
--------
E
A
C
K
--
G
A
D
L
V
T
T
D
V
W
-------------------
K
R
A
-
F
A
D
W
C
V
D
E
E
M
M
S
-
H
-
A
N
S
D
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
A
G
V
I
D
G
P
Q
S
V
V
W
D
E
A
E
N
R
L
H
V
Q
K
A
L
M
E
F
L
L
-------
103
HHSearch
91.26
55%
-92
- C10 -
-
4F2G
1
?
A:
[6-307]
--
I
R
H
Y
L
Q
F
K
D
F
S
L
E
D
Y
E
Y
V
L
E
R
T
G
I
L
K
R
K
F
K
N
-
Y
E
T
Y
H
P
L
H
-
D
-
R
T
L
A
M
I
F
E
K
S
S
T
R
T
R
L
S
F
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A
G
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G
G
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A
V
F
M
S
T
R
D
T
Q
L
G
R
G
E
P
V
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D
S
A
Q
V
I
S
R
M
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D
I
I
M
I
R
T
F
E
Q
D
I
I
Q
R
F
A
E
N
S
R
V
P
V
I
N
G
L
T
N
E
Y
H
P
C
Q
V
L
A
D
I
F
T
Y
Y
E
H
---
R
G
---
P
I
R
G
-
K
-----
T
V
-----
A
W
V
G
D
A
-
N
-
N
M
L
Y
T
W
I
Q
A
A
R
I
L
D
F
K
L
Q
L
S
T
P
P
G
Y
A
L
D
A
-------
K
L
V
-------
D
-------
A
-------
E
S------
A
P
F
Y
Q
V
----
F
D
D
P
N
--------
E
A
C
K
--
G
A
D
L
V
T
T
D
V
W
-------------------
K
R
A
-
F
A
D
W
C
V
D
E
E
M
M
S
-
H
-
A
N
S
D
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
A
G
V
I
D
G
P
Q
S
V
V
W
D
E
A
E
N
R
L
H
V
Q
K
A
L
M
E
F
L
L
L
G
R
L
---
2
PsiBlast_PDB
90.42
49%
-67
- C10 -
-
4OH7
2
?
A:
[15-315]
--
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
A
-
G
E
V
E
R
P
Y
A
-
G
-
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
M
L
T
G
S
E
M
Q
L
G
R
S
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
---
R
G
---
P
I
K
G
-
K
-----
T
F
-----
A
W
M
G
D
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
E
P
K
S
-------
Q
Y
I
D
W
A
----
R
-------
A
-------
N
-------
G
A
G
I
M
S
----
T
T
D
P
E
--------
K
A
A
S
--
G
A
D
C
I
V
T
D
T
W
-----
V
S
M
G
Q
E
D
-
H
A
-
R
-
G
H
N
V
-
F
I
P
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
D
-----
102
HHSearch
89.87
49%
-67
- C10 -
-
4OH7
2
?
A:
[14-315]
-
G
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
A
-
G
E
V
E
R
P
Y
A
-
G
-
K
V
L
A
M
I
F
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K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
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G
G
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L
T
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M
Q
L
G
R
S
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T
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A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
---
R
G
---
P
I
K
G
-
K
-----
T
F
-----
A
W
M
G
D
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
E
P
K
S
-------
Q
Y
I
-------
D
W
A
R
----
A
-------
N
-------
G
A
G
I
M
S
----
T
T
D
P
E
--------
K
A
A
S
--
G
A
D
C
I
V
T
D
T
W
-----
V
S
M
G
Q
E
D
--
H
-
A
R
G
H
N
V
-
F
I
P
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
D
-----
107
HHSearch
89.75
45%
-63
- C10 -
-
4NF2
3
OTC_BACAN
A:
[33-335]
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
K
N
K
-----
Q
E
P
L
L
Q
-
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
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S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
---
T
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
-------
E
I
V
-------
K
K
A
L
A
I
A
K
E
-------
T
-------
G
A
E
I
E
I
----
L
H
N
P
E
--------
L
A
V
N
--
E
A
D
F
I
Y
T
D
V
W
-----
M
S
M
G
Q
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G
-
E
E
--
E
K
Y
T
L
-
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
-----------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
-----
21
PsiBlast_CBE
89.15
49%
-67
- C10 -
-
4OH7
2
?
B:
[15-315]
--
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
A
-
G
E
V
E
R
P
Y
A
-
G
-
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
R
Q
L
G
G
E
T
I
M
L
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G
S
E
M
Q
L
G
R
S
E
T
I
A
D
T
A
K
V
L
S
R
Y
V
D
A
I
M
I
R
T
T
A
H
E
R
M
L
E
L
A
E
Y
A
T
V
P
V
I
N
A
L
T
D
D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
---
R
G
---
P
I
K
G
-
K
-----
T
F
-----
A
W
M
G
D
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
---
S
-------
Q
Y
I
D
W
A
----
R
-------
A
-------
N
-------
G
A
G
I
M
S
----
T
T
D
P
E
--------
K
A
A
S
--
G
A
D
C
I
V
T
D
T
W
-----
V
S
M
G
Q
E
D
-
H
A
-
R
-
G
H
N
V
-
F
I
P
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
D
-----
101
HHSearch
88.95
49%
-68
- C10 -
-
4OH7
2
?
B:
[14-315]
-
G
I
K
H
F
I
D
L
S
T
V
P
A
T
E
L
R
A
I
L
E
D
A
K
A
R
K
A
R
L
K
A
-
G
E
V
E
R
P
Y
A
-
G
-
K
V
L
A
M
I
F
E
K
L
S
T
R
T
R
V
S
F
D
V
G
M
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Q
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G
G
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T
G
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E
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Q
L
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A
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A
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I
R
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T
A
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E
R
M
L
E
L
A
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A
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D
T
H
P
C
Q
I
M
A
D
V
L
T
Y
E
E
H
---
R
G
---
P
I
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G
-
K
-----
T
F
-----
A
W
M
G
D
G
-
N
-
N
V
L
H
S
L
V
E
A
A
A
R
F
D
F
N
V
N
I
A
T
P
K
G
S
---
S
-------
Q
Y
I
-------
D
W
A
R
----
A
-------
N
-------
G
A
G
I
M
S
----
T
T
D
P
E
--------
K
A
A
S
--
G
A
D
C
I
V
T
D
T
W
-----
V
S
M
G
Q
E
D
--
H
-
A
R
G
H
N
V
-
F
I
P
Y
Q
V
N
A
N
L
M
A
-
K
-
A
D
P
K
A
L
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
P
Q
S
V
V
F
D
E
A
E
N
R
L
H
A
Q
K
A
I
L
A
W
C
L
Q
D
-----
106
HHSearch
88.75
48%
-73
- C10 -
-
1A1S
-
OTCA_PYRFU
A:
[4-313]
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
I
-
G
K
P
H
R
L
L
E
-
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
---
T
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
-------
K
V
I
-------
K
-------
W
A
E
Q
N
A
A
E
S
-------
G
G
S
F
E
L
----
L
H
D
P
V
--------
K
A
V
K
--
D
A
D
V
I
Y
T
D
V
W
-----
A
S
M
G
Q
E
A
-
E
A
-
E
E
R
R
K
I
-
F
R
P
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
---
105
HHSearch
88.06
48%
-74
- C10 -
-
1PVV
-
OTCA_PYRFU
A:
[5-314]
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
I
-
G
K
P
H
R
L
L
E
-
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
---
T
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
-------
K
V
I
-------
K
-------
W
A
E
Q
N
A
A
E
S
-------
G
G
S
F
E
L
----
L
H
D
P
V
--------
K
A
V
K
--
D
A
D
V
I
Y
T
D
V
W
-----
A
S
M
G
Q
E
A
-
E
A
-
E
E
R
R
K
I
-
F
R
P
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
---
4
PsiBlast_PDB
87.80
47%
-73
- C10 -
-
1A1S
-
OTCA_PYRFU
A:
[4-310]
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
I
-
G
K
P
H
R
L
L
E
-
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
---
T
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
-------
K
V
I
K
W
A
E
Q
N
A
A
-------
E
-------
S
-------
G
G
S
F
E
L
----
L
H
D
P
V
--------
K
A
V
K
--
D
A
D
V
I
Y
T
D
V
W
-----
A
S
M
G
Q
E
A
-
E
A
-
E
E
R
R
K
I
-
F
R
P
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
------
3
PsiBlast_PDB
87.23
47%
-74
- C10 -
-
1PVV
-
OTCA_PYRFU
A:
[5-311]
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
I
W
Q
K
I
-
G
K
P
H
R
L
L
E
-
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
---
K
G
---
T
I
K
G
-
V
-----
K
V
-----
V
Y
V
G
D
G
-
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
-------
K
V
I
K
W
A
E
Q
N
A
A
-------
E
-------
S
-------
G
G
S
F
E
L
----
L
H
D
P
V
--------
K
A
V
K
--
D
A
D
V
I
Y
T
D
V
W
-----
A
S
M
G
Q
E
A
-
E
A
-
E
E
R
R
K
I
-
F
R
P
F
Q
V
N
K
D
L
V
K
-
H
-
A
K
P
D
Y
M
F
M
H
C
L
P
A
------------------
H
-----------------
R
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
------
111
HHSearch
84.72
41%
-110
- C10 -
-
2EF0
-
?
A:
[7-301]
T
L
P
K
D
L
L
D
F
S
G
Y
G
P
K
E
L
Q
A
L
L
D
L
A
E
Q
L
K
R
E
R
----
Y
R
G
E
D
L
K
-
G
-
K
V
L
A
L
L
F
E
K
P
S
L
R
T
R
T
T
L
E
V
A
M
V
H
L
G
G
H
A
V
Y
L
D
Q
K
Q
V
G
I
G
E
R
E
P
V
R
D
V
A
K
N
L
E
R
F
V
E
G
I
A
A
R
V
F
R
H
E
T
V
E
A
L
A
R
H
A
K
V
P
V
V
N
A
L
S
D
R
A
H
P
L
Q
A
L
A
D
L
L
T
L
K
E
V
---
F
G
---
G
L
A
G
-
L
-----
E
V
-----
A
W
V
G
D
G
-
N
-
N
V
L
N
S
L
L
E
V
A
P
L
A
G
L
K
V
R
V
A
T
P
K
G
Y
E
P
D
P
-------
G
L
L
-------
K
-------
R
-------
A
-------
N
--
A
F
F
----
T
H
D
P
K
--------
E
A
A
L
--
G
A
H
A
L
Y
T
D
V
W
-----
T
----------
E
K
R
L
R
D
-
F
Q
G
F
Q
V
N
G
E
L
L
K
-
L
-
L
R
P
E
G
V
F
L
H
C
L
P
A
------------------
H
-----------------
Y
G
E
E
T
T
E
E
A
V
H
G
P
R
S
R
V
F
D
Q
A
E
N
R
L
H
T
A
K
A
V
L
L
T
L
L
K
------
29
PsiBlast_CBE
84.46
45%
-32
- C10 -
-
2I6U
4
OTC_MYCTU
B:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
P
L
Q
G
P
R
-
G
---
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
---
A
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
-------
S
V
R
-------
A
AAERRAQ
D
-------
T
-------
G
A
S
V
T
V
----
T
A
D
A
H
--------
A
A
A
A
--
G
A
D
V
L
V
T
D
T
W
-----
T
S
M
G
Q
E
N
-
D
G
-
L
D
R
V
K
P
-
F
R
P
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
-----------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
----
28
PsiBlast_CBE
84.44
45%
-32
- C10 -
-
2I6U
3
OTC_MYCTU
C:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
P
L
Q
G
P
R
-
G
---
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
---
A
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
-------
S
V
R
-------
A
AAERRAQ
D
-------
T
-------
G
A
S
V
T
V
----
T
A
D
A
H
--------
A
A
A
A
--
G
A
D
V
L
V
T
D
T
W
-----
T
S
M
G
Q
E
N
-
D
G
-
L
D
R
V
K
P
-
F
R
P
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
-----------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
----
8
PsiBlast_PDB
84.38
45%
-48
- C10 -
-
2P2G
-
OTC_MYCTU
A:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
P
L
Q
G
P
R
-
G
---
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
---
A
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
-------
S
V
R
-------
A
A
A
E
R
R
A
Q
D
-------
T
-------
G
A
S
V
T
V
----
T
A
D
A
H
--------
A
A
A
A
--
G
A
D
V
L
V
T
D
T
W
-------------------
V
K
P
-
F
R
P
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
-----------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
----
108
HHSearch
84.28
46%
-55
- C10 -
-
3TPF
1
OTCA_CAMJE
B:
[2-305]
--
M
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
S
E
L
K
K
E
------
P
K
K
L
L
Q
-
D
-
K
T
L
A
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
F
L
S
S
N
D
L
Q
L
S
R
G
E
P
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
V
N
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
W
---
N
K
---
M
Q
N
G
I
A
-----
K
V
-----
A
F
I
G
D
S
-
N
-
N
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
-------
E
I
W
-------
E
-------
F
A
M
K
Q
A
L
I
S
-------
G
A
K
I
S
L
----
G
Y
D
K
F
--------
E
A
L
K
--
D
K
D
V
V
I
T
D
T
W
-----
V
S
M
G
E
E
N
-
E
K
-
E
R
K
I
K
E
-
F
E
G
F
M
I
D
E
K
A
M
S
-
V
-
A
N
K
D
A
I
L
L
H
C
L
P
A
------------------
Y
-----------------
R
G
Y
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
L
D
N
Q
R
G
---
109
HHSearch
84.26
46%
-54
- C10 -
-
3TPF
1
OTCA_CAMJE
A:
[2-304]
--
M
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
S
E
L
K
K
E
------
P
K
K
L
L
Q
-
D
-
K
T
L
A
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
F
L
S
S
N
D
L
Q
L
S
R
G
E
P
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
V
N
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
W
---
N
K
---
M
Q
N
G
I
A
-----
K
V
-----
A
F
I
G
D
S
-
N
-
N
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
-------
E
I
W
-------
E
-------
F
A
M
K
Q
A
L
I
S
-------
G
A
K
I
S
L
----
G
Y
D
K
F
--------
E
A
L
K
--
D
K
D
V
V
I
T
D
T
W
-----
V
S
M
G
E
E
N
-
E
K
-
E
R
K
I
K
E
-
F
E
G
F
M
I
D
E
K
A
M
S
-
V
-
A
N
K
D
A
I
L
L
H
C
L
P
A
------------------
Y
-----------------
R
G
Y
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
L
D
N
Q
R
----
7
PsiBlast_PDB
84.19
45%
-30
- C10 -
-
2I6U
3
OTC_MYCTU
A:
[2-307]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
S
-
R
R
P
L
Q
G
P
R
-
G
---
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
---
A
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
G
A
N
-
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
-------
S
V
R
-------
A
A
A
E
R
R
A
Q
D
-------
T
-------
G
A
S
V
T
V
----
T
A
D
A
H
--------
A
A
A
A
--
G
A
D
V
L
V
T
D
T
W
-----
T
S
M
G
Q
E
N
-
D
G
-
L
D
R
V
K
P
-
F
R
P
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
-----------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
S
----
104
HHSearch
83.94
42%
-58
* C10 *
-
1VLV
-
OTC_THEMA
A:
[17-324]
L
K
G
R
S
L
L
T
L
L
D
F
S
P
E
E
I
R
Y
L
L
D
I
S
K
Q
V
K
M
E
N
R
S
-
K
L
R
T
E
R
F
K
-
G
-
M
T
L
A
M
I
F
E
K
R
S
T
R
T
R
L
A
F
E
T
A
F
A
E
E
G
G
H
P
I
F
L
S
P
N
D
I
H
L
G
A
K
E
S
L
E
D
T
A
R
V
L
G
R
M
V
D
A
I
M
F
R
G
Y
K
Q
E
T
V
E
K
L
A
E
Y
S
G
V
P
V
Y
N
G
L
T
D
E
F
H
P
T
Q
A
L
A
D
L
M
T
I
E
E
N
---
F
G
---
R
L
K
G
-
V
-----
K
V
-----
V
F
M
G
D
T
-
R
N
N
V
A
T
S
L
M
I
A
C
A
K
M
G
M
N
F
V
A
C
G
P
E
E
L
K
P
R
S
-------
D
V
F
-------
K
R
C
Q
E
I
V
K
E
-------
T
-------
D
G
S
V
S
F
----
T
S
N
L
E
--------
E
A
L
A
--
G
A
D
V
V
Y
T
D
V
W
-----
A
------------
R
M
A
L
-
L
K
P
Y
Q
V
N
E
R
V
M
E
-
M
T
G
K
S
E
T
I
F
M
H
C
L
P
A
------------------
V
-----------------
K
G
Q
E
V
T
Y
E
V
I
E
G
K
Q
S
R
V
W
D
E
A
E
N
R
K
H
T
I
K
A
V
M
I
A
T
L
-------
9
PsiBlast_PDB
83.40
43%
-49
- C10 -
-
3TPF
1
OTCA_CAMJE
A:
[3-303]
---
K
H
F
L
T
L
R
D
F
S
K
E
E
I
L
S
L
V
N
H
A
S
E
L
K
K
--
E
P
-
K
K
L
L
Q
----
D
-
K
T
L
A
M
I
F
E
K
N
S
T
R
T
R
M
A
F
E
L
A
I
T
E
L
G
G
K
A
L
F
L
S
S
N
D
L
Q
L
S
R
G
E
P
V
K
D
T
A
R
V
I
G
A
M
V
D
F
V
M
M
R
V
N
K
H
E
T
L
L
E
F
A
R
Y
S
K
A
P
V
I
N
A
L
S
E
L
Y
H
P
T
Q
V
L
G
D
L
F
T
I
K
E
W
---
N
K
---
M
Q
N
G
I
A
-----
K
V
-----
A
F
I
G
D
S
-
N
-
N
M
C
N
S
W
L
I
T
A
A
I
L
G
F
E
I
S
I
A
M
P
K
N
Y
K
I
S
P
-------
E
-
I
-------
W
-------
E
-------
F
-------
A
M
K
Q
A
L
----
I
S
G
A
K
I
S
L
G
YD
K
F
E
A
L
K
--
D
K
D
V
V
I
T
D
T
W
-----
V
S
M
G
E
E
N
-
E
K
-
E
R
K
I
K
E
-
F
E
G
F
M
I
D
E
K
A
M
S
-
V
-
A
N
K
D
A
I
L
L
H
C
L
P
A
------------------
Y
-----------------
R
G
Y
E
V
S
E
E
I
F
E
K
H
A
D
V
I
F
E
E
A
R
N
R
L
Y
V
V
K
A
L
L
C
F
L
D
N
Q
-----
6
PsiBlast_PDB
82.52
45%
-3
- C10 -
-
4NF2
3
OTC_BACAN
A:
[36-329]
---
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
K
N
K
Q
------
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
---
T
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
-------
E
I
V
K
K
A
L
A
I
A
K
-------
E
-------
T
-------
G
A
E
I
E
I
----
L
H
N
P
E
--------
L
A
V
N
--
E
A
D
F
I
Y
T
D
V
W
-----
M
S
M
G
Q
E
G
-
E
E
-
E
-
K
Y
T
L
-
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
-----------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
-----------
118
HHSearch
82.49
47%
0
- C10 -
-
2I6U
3
OTC_MYCTU
C:
[2-306]
--
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
K
D
P
V
----
S
R
R
P
L
Q
-
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
---
K
G
---
A
L
R
G
-
L
-----
R
L
-----
S
Y
F
G
D
G
-
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
-------
S
V
R
-------
A
AAERRAQ
D
-------
T
-------
G
A
S
V
T
V
----
T
A
D
A
H
--------
A
A
A
A
--
G
A
D
V
L
V
T
D
T
W
-----
T
S
M
G
Q
E
N
-
D
G
-
L
D
R
V
K
P
-
F
R
P
F
Q
L
N
S
R
L
L
A
-
L
-
A
D
S
D
A
I
V
L
H
C
L
P
A
------------------
H
-----------------
R
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
-----
22
PsiBlast_CBE
82.14
45%
-1
- C10 -
-
4NF2
3
OTC_BACAN
C:
[36-329]
---
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
K
N
K
Q
------
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
---
T
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
-------
E
I
V
KKALAIA
K
-------
E
-------
T
-------
G
A
E
I
E
I
----
L
H
N
P
E
--------
L
A
V
N
--
E
A
D
F
I
Y
T
D
V
W
-----
M
S
M
G
Q
E
G
-
E
E
-
E
-
K
Y
T
L
-
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
-----------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
-----------
23
PsiBlast_CBE
82.10
45%
-3
- C10 -
-
4NF2
3
OTC_BACAN
B:
[36-329]
---
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
K
N
K
Q
------
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
---
T
N
---
T
F
K
G
-
I
-----
K
L
-----
A
Y
V
G
D
G
-
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
-------
E
I
V
KKALAIA
K
-------
E
-------
T
-------
G
A
E
I
E
I
----
L
H
N
P
E
--------
L
A
V
N
--
E
A
D
F
I
Y
T
D
V
W
-----
M
S
M
G
Q
E
G
-
E
E
-
E
-
K
Y
T
L
-
F
Q
P
Y
Q
I
N
K
E
L
V
K
-
H
-
A
K
Q
T
Y
H
F
L
H
C
L
P
A
------------------
H
-----------------
R
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
-----------
17
PsiBlast_PDB
78.21
39%
-1
- C10 -
-
1FVO
1
OTC_HUMAN
A:
[7-311]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
-------
K
-------
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
-----------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-----
71
PsiBlast_CBE
78.09
34%
-30
- C10 -
-
4JFR
2
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
16
PsiBlast_PDB
77.93
39%
-5
- C10 -
-
1EP9
1
OTC_HUMAN
A:
[7-311]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
-------
K
-------
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
-----------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-----
69
PsiBlast_CBE
77.80
34%
-26
- C10 -
-
4JHX
2
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
14
PsiBlast_PDB
77.66
39%
-0
- C10 -
-
1OTH
1
OTC_HUMAN
A:
[7-311]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
-------
K
-------
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
-----------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-----
15
PsiBlast_PDB
77.65
39%
1
- C10 -
-
1C9Y
2
OTC_HUMAN
A:
[7-311]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
-------
K
-------
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
-----------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-----
115
HHSearch
77.60
39%
-1
- C10 -
-
1OTH
1
OTC_HUMAN
A:
[4-314]
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
-
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
-------
S
V
T
-------
K
L
A
E
Q
Y
A
K
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
R
------------------------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
--
72
PsiBlast_CBE
77.52
34%
-28
- C10 -
-
4JFR
1
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
20
PsiBlast_PDB
77.26
37%
-28
- C10 -
-
1DUV
3
OTC1_ECOLI
G:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
-
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
---------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
-------
A
L
V
-------
T
-------
E
-------
C
RALAQQN
G
G
N
I
T
L
----
T
E
D
V
A
--------
K
G
V
E
--
G
A
D
F
I
Y
T
D
V
W
-----
V
S
M
G
E
A
K
-
E
K
-
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-----------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
-----------
30
PsiBlast_CBE
77.25
39%
-2
- C10 -
-
1FVO
1
OTC_HUMAN
B:
[7-311]
---
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
-
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
SVTKLAE
Q
Y
A
-------
K
-------
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
-------------------
R
-----------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-----
40
PsiBlast_CBE
77.21
37%
-28
- C10 -
-
1DUV
2
OTC1_ECOLI
H:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
-
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
---------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
-------
A
L
V
-------
T
-------
E
-------
C
RALAQQN
G
G
N
I
T
L
----
T
E
D
V
A
--------
K
G
V
E
--
G
A
D
F
I
Y
T
D
V
W
-----
V
S
M
G
E
A
K
-
E
K
-
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-----------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
-----------
75
PsiBlast_CBE
77.12
34%
-25
- C10 -
-
4H31
12
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
39
PsiBlast_CBE
76.99
37%
-28
- C10 -
-
1DUV
2
OTC1_ECOLI
I:
[6-327]
---
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
-
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
---------
L
P
G
-
K
AFNEM
T
L
-----
V
Y
A
G
D
A
R
N
-
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
-------
A
L
V
-------
T
-------
E
-------
C
RALAQQN
G
G
N
I
T
L
----
T
E
D
V
A
--------
K
G
V
E
--
G
A
D
F
I
Y
T
D
V
W
-----
V
S
M
G
E
A
K
-
E
K
-
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-----------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
-----------
64
PsiBlast_CBE
76.96
34%
-29
- C10 -
-
4JQO
3
OTC_VIBVU
C:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
116
HHSearch
76.93
39%
-3
- C10 -
-
1FVO
1
OTC_HUMAN
B:
[4-314]
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
-
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
---
Y
S
---
S
L
K
G
-
L
-----
T
L
-----
S
W
I
G
D
G
-
N
-
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
-------
S
V
T
-------
K
LAEQYAK
E
-------
N
-------
G
T
K
L
L
L
----
T
N
D
P
L
--------
E
A
A
H
--
G
G
N
V
L
I
T
D
T
W
-----
I
S
M
G
R
E
E
-
E
K
-
K
K
R
L
Q
A
-
F
Q
G
Y
Q
V
T
M
K
T
A
K
-
V
-
A
A
S
D
W
T
F
L
H
C
L
P
R
------------------------------------
K
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
Y
S
P
--
65
PsiBlast_CBE
76.71
34%
-28
- C10 -
-
4JQO
3
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
114
HHSearch
76.63
40%
-10
- C10 -
-
1DUV
2
OTC1_ECOLI
H:
[3-332]
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
A
D
K
K
S
-
G
K
E
E
A
K
L
T
-
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
---
L
P
GK-
A
F
N
E
-
M
-----
T
L
-----
V
Y
A
G
D
A
-
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
-------
A
L
V
-------
T
ECRALAQ
Q
-------
N
-------
G
G
N
I
T
L
----
T
E
D
V
A
--------
K
G
V
E
--
G
A
D
F
I
Y
T
D
V
W
-----
V
S
M
G
E
A
K
-
E
K
W
A
E
R
I
A
L
-
L
R
E
Y
Q
V
N
S
K
M
M
Q
-
L
T
G
N
P
E
V
K
F
L
H
C
L
P
A
FHDDQTTLGKKMAEEFGL
H
-----------------
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
------
74
PsiBlast_CBE
76.41
34%
-24
- C10 -
-
4H31
10
OTC_VIBVU
B:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
66
PsiBlast_CBE
76.32
34%
-26
- C10 -
-
4JQO
5
OTC_VIBVU
A:
[32-352]
---
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
K
A
K
Y
A
-
G
T
E
Q
K
K
L
L
-
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
---
S
------
Q
G
-
K
-----
A
L
AD
I
Q
F
A
Y
L
G
D
A
R
N
-
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
-------
E
L
V
-------
A
A
C
Q
A
I
A
K
Q
-------
T
-------
G
G
K
I
T
L
----
T
E
N
V
A
--------
E
G
V
Q
--
G
C
D
F
L
Y
T
D
V
W
-----
V
S
M
G
E
S
P
-
E
A
W
D
E
R
V
A
L
-
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
T
-
G
N
P
N
V
K
F
M
H
C
L
P
A
------------------
F
HNDET
T
I
G
K
Q
V
A
D
K
F
GM
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
-----------
117
HHSearch
76.09
36%
-22
- C10 -
-
4A8T
2
PTC_ENTFA
A:
[22-337]
S
M
K
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
-
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
---
L
P
EGK
K
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
-------
E
H
Q
-------
A
-------
K
L
A
K
N
C
E
V
S
-------
G
G
S
F
L
V
----
T
D
D
A
---------
S
S
V
E
--
G
A
D
F
L
Y
T
D
V
W
-----
Y
G
L
Y
E
A
E
L
S
E
E
E
R
M
K
V
F
-
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
Y
E
A
K
-
47
PsiBlast_CBE
74.73
35%
-15
- C10 -
-
4A8H
4
PTC_ENTFA
B:
[3-311]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
-
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
---
K
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
-------
E
H
Q
-------
A
-------
K
-------
L
-------
A
K
N
C
E
V
SGGS
F
L
V
T
D
--------
D
A
S
S
VE
G
A
D
F
L
Y
T
D
V
W
YGLYE
A
E
L
S
E
E
E
-
R
M
-
K
V
---
F
-
Y
P
K
Y
Q
V
N
Q
E
M
M
D
-
R
-
A
G
A
N
C
K
F
M
H
C
L
P
A
------------------
T
-----------------
R
G
E
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
V
Y
L
M
N
D
-----
48
PsiBlast_CBE
74.64
35%
-15
- C10 -
-
4A8H
4
PTC_ENTFA
A:
[3-311]
---
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
E
A
I
K
N
-
G
Y
Y
P
Q
L
L
K
-
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
LPE
G
K
---
K
L
E
D
-
C
-----
K
V
-----
V
F
V
G
D
A
-
T
-
Q
V
C
F
S
L
G
L
I
T
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-------
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-------
A
-------
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-------
A
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C
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G
S
F
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D
--------
D
A
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A
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A
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---
F
-
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M
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A
G
A
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C
L
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A
------------------
T
-----------------
R
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V
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-----