@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSL9: (2017-12-09 )
MPKRTDIKSILIIGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPSMADATYIEPITWQTVAQIIEKERPDAVLPTMGGQTALNCALALDENGVLEKYGVELIGATKEAIEKAEDRKLFDEAMRKIGLECPKAAIAETMEEALEIQSRFGFPVIIRPSFTMGGSGGGIAYNREEFLEICERGFDLSPTHQLLIDESLIGWKEYEMEVVRDKNDNCIIVCAIENFDPMGVHTGDSITVAPAQTLTDKEYQLMRNASVAVLREIGVETGGSNVQFGINPKDGRMVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELKNDITGGVTPASFEPSIDYVVTKIPRFNFEKFPQAEPVLTTQMKSVGEVMAIGRNFQESVQKALRGLEVGVSGFDEKIEAGATNVKETILKELKVPGPERIWYVADAFRHGFSLDDVFEATKIDRWFLIQIQDIVNTEAQVKTLGFGDLTAENIRSFKRKGLSDLRIANLMGISQKQFRKQRWNLGVYPVYKRVDTCAAEFESGTAYMYSTYDEECEANPSNRDKIMVIGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDISDRLYFEPVTLEDVLEIVRTEKPKGVIVQYGGQTPLKLARALEEAGTPIIGTSPDAIDRAEDRERFQQMIQRLQLRQPNNSIVKSAEEGISEAAKVGYPLVVRPSYVLGGRAMEIVYNEDELKRYLREAVQASNEAPVLLDHFLDDATEVDVDCVSDGKDVVIGGIMQHIEQAGIHSGDSACSIPPYSLSKEIQNEMRRQTIAMAKELGVVGLMNVQFAVKGNDIYVLEVNPRASRTVPFVSKCIGESLAKVAARCMAGQSLESQGFTKEIIPNRFAVKEAVFPFAKFPGVDPMLGPEMKSTGEVMGVGQTFGEAFYKAVLGSNDRLPGLPTEGEVKHAFLSVRESDKKYIADIAKKLVEYGFKLVATGGTYQVLKEAGLECESVNKVTEGRPHIVDRLKNGEIHLIVNTTEGKQAQYDSAMIRRAALQGKVYYTTTINGAEAVCQAFAVKLPMDVYRLQDLTVG
Atome Classification :
(20 SA)
.........10........20........30........40........50......---.---.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.---..-....420.......430.......440-.......450..------.------....460......----.-470.......480........490.......500.......510.......520.......530.......540......-.550...-.-...560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.....---..880---......-..890.......900.......910.......920.......930.......940.......--950.......960.......970.......980.......990.......1000-----.----......1010......1020....-...1030......1040......1050......1060......1070...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPKRTDI
K
S
I
L
I
IGAG
P
I
V
I
GQACEFDYS
G
A
Q
A
C
K
A
L
R
EEG
Y
R
V
I
L
VNSNP
A
T
I
MTD---P---SMAD
A
T
Y
IEPI
T
W
Q
T
V
A
Q
I
I
E
KERPDAVLPTMGGQ
T
A
L
N
C
A
L
ALDENG
V
L
E
K
Y
G
V
E
LIG
A
T
K
E
A
I
E
K
A
E
D
R
K
L
F
D
E
A
M
R
KIGLEC
P
K
A
A
I
A
E
T
M
E
E
A
L
E
I
Q
S
RFG
F
P
V
I
I
R
P
S
F
T
MGGSGGGIAY
N
R
E
E
F
L
E
I
C
E
RGFDLSPT
H
Q
L
L
IDESLI
G
W
K
E
Y
E
M
E
V
VRDKND
N
C
I
I
V
C
A
IENFDPMGVHTGD
S
I
T
VAPAQTL
T
D
K
E
Y
Q
L
M
R
N
A
S
V
A
V
L
R
E
IGVETGGSN
V
Q
F
G
INPKD
G
R
M
V
V
I
EMNPRVSR
S
S
ALASKATGF
P
I
A
K
I
A
A
K
L
AVG
Y
T
L
D
E
L
K
N
D
ITGGVTPASFEPS
I
D
Y
V
V
TKIPRF
N
F
E
KFPQAEP
V
L
T
T
Q
M
K
S
V
G
E
V
M
A
IG
R
N
F
Q
E
S
V
Q
K
A
L
R
G
L
E
VGVSG
F
D
E
K
I
---
E
A-GA
T
N
V
K
E
T
I
L
K
E
LKVPGP
E
R
I
W
Y
V
A
D
A
-
F
RHGF
S
L
D
D
V
F
E
------
A
------TKI
D
R
W
F
L
I
Q
I
Q
D
----I-VNTE
A
Q
V
K
T
LGF-GDL
T
A
E
N
I
R
S
F
K
R
KGL
S
D
L
R
I
A
N
LMGI
S
Q
K
Q
F
R
K
Q
RWNLG
V
Y
P
V
Y
K
R
V
D
T
C
A
A
EFESG
T
A
Y
M
Y
STYD-EECEANP-S-NR
D
K
I
M
V
IGG
G
P
N
RIGQGIE
F
D
Y
C
C
V
H
A
A
L
A
M
REDGY
E
T
I
M
V
NCNPETVSTDYDISD
R
L
Y
FEPV
T
L
E
D
V
L
E
I
V
RTEKP
K
G
V
I
V
QYGGQ
T
P
L
K
L
A
R
A
L
E
EAGT
P
I
IGTSPDAI
D
R
A
E
D
R
E
R
F
Q
Q
M
I
Q
R
L
QLRQP
N
N
S
I
V
K
S
A
E
E
G
I
S
E
A
A
KVGY
P
L
V
V
RPS
Y
V
LG
G
R
A
M
E
I
V
Y
N
E
D
E
L
K
R
Y
L
R
E
A
V
Q
ASNEAP
V
L
L
D
H
FLDDATEV
D
V
D
CVSDGK
D
V
V
I
G
G
I
M
Q
H
I
E
Q
AGIHSGDSACSIP
P
Y
S
L
S
K
E
I
Q
N
E
M
R
R
Q
T
I
A
M
A
K
ELG
V
V
G
L
M
N
V
Q
F
A
V
KG
N
D
I
Y
V
L
E
VNPRASR
T
V
P
F
V
S
K
C
I
G
E
S
L
A
K
V
A
A
R
C
MAGQSLESQG---
F
T
K
E
----IIPN
R
F
-
A
V
K
E
A
VFPFAKFPGVDPMLGPEMKSTG
E
V
M
G
V
G
Q
T
F
G
E
A
F
Y
K
A
V
LGSNDRLPGLPTEG
E
V
K
H
--
A
F
L
S
VRES
D
K
K
Y
I
A
D
I
A
K
K
L
V
EYG
F
K
L
V
ATG
G
T
Y
Q
V
L
K
E
AGLEC
E
S
V
N
K
VT-EG-----R----
P
H
I
V
D
RLKNG
E
I
H
L
I
V
NT-TEGKQ-
A
Q
Y
D
S
A
M
I
R
R
A
ALQG
K
V
Y
Y
T
T
TIN
G
A
E
A
V
C
Q
A
F
A
V
KLP
M
D
V
Y
R
L
QDLTVG
88
HHSearch
71.85
73%
-30
- C1 -
-
1BXR
-
CARB_ECOLI
A:
[1-1071]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
S
T
-
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
Y
V
L
G
G
R
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
S
V
S
N
D
A
P
V
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
---
K
H
G
---
R
--
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
2
PsiBlast_PDB
71.50
72%
-29
- C1 -
-
1BXR
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
Y
V
L
G
G
R
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
S
V
S
N
D
A
P
V
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
3
PsiBlast_PDB
71.22
72%
-33
- C1 -
-
1C30
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
38
PsiBlast_CBE
71.14
72%
-28
- C1 -
-
1BXR
24
CARB_ECOLI
G:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
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F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
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T
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P
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A
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D
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A
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D
R
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R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
Y
V
L
G
G
R
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
S
V
S
N
D
A
P
V
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
GR
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
6
PsiBlast_PDB
70.97
72%
-30
- C1 -
-
1KEE
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
87
HHSearch
70.80
72%
-30
- C1 -
-
1A9X
-
CARB_ECOLI
E:
[1-1071]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
S
T
-
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
A
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
---
K
H
G
---
R
--
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
H
A
Q
7
PsiBlast_PDB
70.80
72%
-30
- C1 -
-
1T36
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
5
PsiBlast_PDB
70.78
72%
-28
- C1 -
-
1CS0
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
21
PsiBlast_CBE
70.75
72%
-32
- C1 -
-
1T36
34
CARB_ECOLI
G:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
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R
K
G
F
A
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A
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L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
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F
A
T
D
T
A
Y
M
Y
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T
Y
E
-
E
E
C
E
A
N
P
-
S
T
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R
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K
I
M
V
L
G
G
G
P
N
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I
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Q
G
I
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F
D
Y
C
C
V
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A
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L
A
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G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
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P
D
A
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D
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A
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D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
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Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
GR
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
4
PsiBlast_PDB
70.69
72%
-28
- C1 -
-
1C3O
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
10
PsiBlast_PDB
70.60
72%
-27
- C1 -
-
1A9X
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
A
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
1
PsiBlast_PDB
70.53
72%
-30
* C1 *
-
1JDB
-
CARB_ECOLI
B:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
L
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
--------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
GR
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
8
PsiBlast_PDB
70.34
72%
-26
- C1 -
-
1CE8
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
E
M
N
P
R
V
S
R
S
S
A
L
A
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K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
E
L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
9
PsiBlast_PDB
70.27
72%
-29
- C1 -
-
1M6V
-
CARB_ECOLI
A:
[1-1068]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
D
R
R
R
F
D
V
A
M
K
K
I
G
L
E
T
A
R
S
G
I
A
H
T
M
E
E
A
L
A
V
A
A
D
V
G
F
P
C
I
I
R
P
S
F
T
M
G
G
S
G
G
G
I
A
Y
N
R
E
E
F
E
E
I
C
A
R
G
L
D
L
S
P
T
K
E
L
L
I
D
E
S
L
I
G
W
K
E
Y
E
M
E
V
V
R
D
K
N
D
N
C
I
I
V
C
S
I
E
N
F
D
A
M
G
I
H
T
G
D
S
I
T
V
A
P
A
Q
T
L
T
D
K
E
Y
Q
I
M
R
N
A
S
M
A
V
L
R
E
I
G
V
E
T
G
G
S
N
V
Q
F
A
V
N
P
K
N
G
R
L
I
V
I
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M
N
P
R
V
S
R
S
S
A
L
A
S
K
A
T
G
F
P
I
A
K
V
A
A
K
L
A
V
G
Y
T
L
D
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L
M
N
D
I
T
G
G
R
T
P
A
S
F
E
P
S
I
D
Y
V
V
T
K
I
P
R
F
N
F
E
K
F
A
G
A
N
D
R
L
T
T
Q
M
K
S
V
G
E
V
M
A
I
G
R
T
Q
Q
E
S
L
Q
K
A
L
R
G
L
E
V
G
A
T
G
F
D
P
K
V
---
S
L
-
D
D
P
E
A
L
T
K
I
R
R
E
L
K
D
A
G
A
D
R
I
W
Y
I
A
D
A
-
F
R
A
G
L
S
V
D
G
V
F
N
------
L
------
T
N
I
D
R
W
F
L
V
Q
I
E
E
----
L
-
V
R
L
E
E
K
V
A
E
V
G
I
-
T
G
L
N
A
D
F
L
R
Q
L
K
R
K
G
F
A
D
A
R
L
A
K
L
A
G
V
R
E
A
E
I
R
K
L
R
D
Q
Y
D
L
H
P
V
Y
K
R
V
D
T
C
A
A
E
F
A
T
D
T
A
Y
M
Y
S
T
Y
E
-
E
E
C
E
A
N
P
-
S
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
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F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
Y
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
P
S
------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
R
G
L
M
N
V
Q
F
A
V
K
N
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
---
V
T
K
E
----
V
I
P
P
Y
Y
-
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
--------
K
H
G
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
A
G
I
N
P
R
L
V
N
K
V
H
-
E
G
-----
R
----
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
-
T
S
G
R
R
-
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
V
H
Y
D
T
T
L
N
G
G
F
A
T
A
M
A
L
N
A
D
A
T
E
K
V
I
S
V
Q
E
M
---
11
PsiBlast_PDB
66.08
40%
0
- C- -
-
5DOU
5
CPSM_HUMAN
A:
[408-1469]
---
R
V
E
V
S
K
V
L
I
L
G
S
G
G
L
S
I
G
Q
A
G
E
F
D
Y
S
G
S
Q
A
V
K
A
M
K
E
E
N
V
K
T
V
L
M
N
P
N
I
A
S
V
Q
T
N
---
E
VGL
K
Q
A
D
T
V
Y
F
L
P
I
T
P
Q
F
V
T
E
V
I
K
A
E
Q
P
D
G
L
I
L
G
M
G
G
Q
T
A
L
N
C
G
V
E
L
F
K
R
G
V
L
K
E
Y
G
V
K
V
L
G
T
S
V
E
S
I
M
A
T
E
D
R
Q
L
F
S
D
K
L
N
E
I
N
E
K
I
A
P
S
F
A
V
E
S
I
E
D
A
L
K
A
A
D
T
I
G
Y
P
V
M
I
R
S
A
Y
A
L
G
G
L
G
S
G
I
C
P
N
R
E
T
L
M
D
L
S
T
K
A
F
A
M
--
T
N
Q
I
L
V
E
K
S
V
T
G
W
K
E
I
E
Y
E
V
V
R
D
A
D
D
N
C
V
T
V
C
N
M
E
N
V
D
A
M
G
V
H
T
G
D
S
V
V
V
A
P
A
Q
T
L
S
N
A
E
F
Q
M
L
R
R
T
S
I
N
V
V
R
H
L
G
I
-
V
G
E
C
N
I
Q
F
A
L
H
P
T
S
M
E
Y
C
I
I
E
V
N
A
R
L
S
R
S
S
A
L
A
S
K
A
T
G
Y
P
L
A
F
I
A
A
K
I
A
L
G
I
P
L
P
E
I
K
N
-
V
V
S
G
K
T
S
A
C
F
E
P
S
L
D
Y
M
V
T
K
I
P
R
W
D
L
D
R
F
H
G
T
S
S
R
I
G
S
S
M
K
S
V
G
E
V
M
A
I
G
R
T
F
E
E
S
F
Q
K
A
L
R
M
C
H
P
S
I
E
G
F
T
P
R
L
PMN
K
E
-
W
P
S
N
L
D
--
L
R
K
E
L
S
E
P
S
S
T
R
I
Y
A
I
A
K
A
-
I
D
D
N
M
S
L
D
E
I
E
K
------
L
------
T
Y
I
D
K
W
F
L
Y
K
M
R
D
----
I
-
L
N
M
E
K
T
L
K
G
L
N
S
-
E
S
M
T
E
E
T
L
K
R
A
K
E
I
G
F
S
D
K
Q
I
S
K
C
L
G
L
T
E
A
Q
T
R
E
L
R
L
K
K
N
I
H
P
W
V
K
Q
I
D
T
L
A
A
E
Y
P
S
V
T
N
Y
L
Y
V
T
Y
N
G
Q
E
H
D
V
N
F
-
D
-
D
H
G
-
M
M
V
L
G
C
G
P
Y
H
I
G
S
S
V
E
F
D
W
C
A
V
S
S
I
R
T
L
R
Q
L
G
K
K
T
V
V
V
N
C
N
P
E
T
V
S
T
D
F
D
E
C
D
K
L
Y
F
E
E
L
S
L
E
R
I
L
D
I
Y
H
Q
E
A
C
G
G
C
I
I
S
V
G
G
Q
I
P
N
N
L
A
V
P
L
Y
K
N
G
V
K
I
M
G
T
S
P
L
Q
I
D
R
A
E
D
R
S
I
F
S
A
V
L
D
E
L
K
V
A
Q
A
P
W
K
A
V
N
T
L
N
E
A
L
E
F
A
K
S
V
D
Y
P
C
L
L
R
---------
M
N
V
V
F
S
E
D
----------------
P
V
V
L
T
K
F
V
E
G
A
R
E
V
E
M
D
A
V
G
K
D
G
R
V
I
S
H
A
I
S
E
H
V
E
D
A
G
V
H
S
G
D
A
T
L
M
L
P
T
Q
T
I
S
Q
G
A
I
E
K
V
K
D
A
T
R
K
I
A
K
A
F
A
I
S
G
P
F
N
V
Q
F
L
V
K
G
N
D
V
L
V
I
E
C
N
L
R
A
S
R
S
F
P
F
V
S
K
T
L
G
V
D
F
I
D
V
A
T
K
V
M
I
G
E
N
V
D
E
K
H
LPT
L
D
H
P
----
I
I
P
A
D
Y
V
A
I
K
A
P
M
F
S
W
P
R
L
R
D
A
D
P
I
L
R
C
E
M
A
S
T
G
E
V
A
C
F
G
E
G
I
H
T
A
F
L
K
A
M
L
S
T
G
F
K
I
P
Q
-------
K
G
--
I
L
I
G
I
Q
Q
S
F
R
P
R
F
L
G
V
A
E
Q
L
H
N
E
G
F
K
L
F
A
T
E
A
T
S
D
W
L
N
A
N
N
V
P
A
T
P
V
A
W
P
S
Q
E
G
-----
Q
NPSL
S
S
I
R
K
L
I
R
D
G
S
I
D
L
V
I
N
L
P
N
N
N
T
K
-
F
V
H
D
N
Y
V
I
R
R
T
A
V
D
S
G
I
P
L
L
T
N
F
Q
V
T
K
L
F
A
E
A
------------------
89
HHSearch
48.59
40%
17
- C1 -
-
5DOU
-
CPSM_HUMAN
D:
[406-1482]
-
A
S
R
V
E
V
S
K
V
L
I
L
G
S
G
G
L
S
I
G
Q
A
G
E
F
D
Y
S
G
S
Q
A
V
K
A
M
K
E
E
N
V
K
T
V
L
M
N
P
N
I
A
S
V
Q
T
N
EVG
L
---
K
Q
A
D
T
V
Y
F
L
P
I
T
P
Q
F
V
T
E
V
I
K
A
E
Q
P
D
G
L
I
L
G
M
G
G
Q
T
A
L
N
C
G
V
E
L
F
K
R
G
V
L
K
E
Y
G
V
K
V
L
G
T
S
V
E
S
I
M
A
T
E
D
R
Q
L
F
S
D
K
L
N
E
I
N
E
K
I
A
P
S
F
A
V
E
S
I
E
D
A
L
K
A
A
D
T
I
G
Y
P
V
M
I
R
S
A
Y
A
L
G
G
L
G
S
G
I
C
P
N
R
E
T
L
M
D
L
S
T
K
A
F
A
--
M
T
N
Q
I
L
V
E
K
S
V
T
G
W
K
E
I
E
Y
E
V
V
R
D
A
D
D
N
C
V
T
V
C
N
M
E
N
V
D
A
M
G
V
H
T
G
D
S
V
V
V
A
P
A
Q
T
L
S
N
A
E
F
Q
M
L
R
R
T
S
I
N
V
V
R
H
L
G
I
-
V
G
E
C
N
I
Q
F
A
L
H
P
T
S
M
E
Y
C
I
I
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V
N
A
R
L
S
R
S
S
A
L
A
S
K
A
T
G
Y
P
L
A
F
I
A
A
K
I
A
L
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I
P
L
P
E
I
K
N
V
V
S
G
-
K
T
S
A
C
F
E
P
S
L
D
Y
M
V
T
K
I
P
R
W
D
L
D
R
F
H
G
T
S
S
R
I
G
S
S
M
K
S
V
G
E
V
M
A
I
G
R
T
F
E
E
S
F
Q
K
A
L
R
M
C
H
P
S
I
E
G
F
T
P
R
L
---
P
M
N
K
E
W
P
S
N
L
D
L
R
K
E
L
S
E
P
S
S
T
R
I
Y
A
I
A
K
A
-
I
D
D
N
M
S
L
D
E
I
E
K
------
L
------
T
Y
I
D
K
W
F
L
Y
K
M
R
D
----
I
-
L
N
M
E
K
T
L
K
G
L
N
S
-
E
S
M
T
E
E
T
L
K
R
A
K
E
I
G
F
S
D
K
Q
I
S
K
C
L
G
L
T
E
A
Q
T
R
E
L
R
L
K
K
N
I
H
P
W
V
K
Q
I
D
T
L
A
A
E
Y
P
S
V
T
N
Y
L
Y
V
T
Y
N
-
G
Q
E
H
D
V
N
-
F
-
D
D
H
G
M
M
V
L
G
C
G
P
Y
H
I
G
S
S
V
E
F
D
W
C
A
V
S
S
I
R
T
L
R
Q
L
G
K
K
T
V
V
V
N
C
N
P
E
T
V
S
T
D
F
D
E
C
D
K
L
Y
F
E
E
L
S
L
E
R
I
L
D
I
Y
H
Q
E
A
C
G
G
C
I
I
S
V
G
G
Q
I
P
N
N
L
A
V
P
L
Y
K
N
G
V
K
I
M
G
T
S
P
L
Q
I
D
R
A
E
D
R
S
I
F
S
A
V
L
D
E
L
K
V
A
Q
A
P
W
K
A
V
N
T
L
N
E
A
L
E
F
A
K
S
V
D
Y
P
C
L
L
R
---------
M
N
V
V
F
S
E
D
E
M
K
K
F
L
--------
E
H
P
V
V
L
T
K
F
V
E
G
A
R
E
V
E
M
D
A
V
G
K
D
G
R
V
I
S
H
A
I
S
E
H
V
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D
A
G
V
H
S
G
D
A
T
L
M
L
P
T
Q
T
I
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Q
G
A
I
E
K
V
K
D
A
T
R
K
I
A
K
A
F
A
I
S
G
P
F
N
V
Q
F
L
V
K
G
N
D
V
L
V
I
E
C
N
L
R
A
S
R
S
F
P
F
V
S
K
T
L
G
V
D
F
I
D
V
A
T
K
V
M
I
G
E
N
V
D
E
K
H
---
L
P
T
L
D
H
P
I
I
P
A
D
Y
V
-
A
I
K
A
P
M
F
S
W
P
R
L
R
D
A
D
P
I
L
R
C
E
M
A
S
T
G
E
V
A
C
F
G
E
G
I
H
T
A
F
L
K
A
M
L
S
T
G
F
K
I
P
---
Q
K
----
G
--
I
L
I
G
I
Q
Q
S
F
R
P
R
F
L
G
V
A
E
Q
L
H
N
E
G
F
K
L
F
A
T
E
A
T
S
D
W
L
N
A
N
N
V
P
A
T
P
V
A
W
P
S
-
Q
E
GQNPS
L
----
S
S
I
R
K
L
I
R
D
G
S
I
D
L
V
I
N
L
-
P
N
N
N
T
K
F
V
H
D
N
Y
V
I
R
R
T
A
V
D
S
G
I
P
L
L
T
N
F
Q
V
T
K
L
F
A
E
A
V
Q
K
----
D
S
K
S
L
F
H
Y
R
Q
-
91
HHSearch
47.37
32%
-59
- C1 -
-
1BXR
-
CARB_ECOLI
A:
[557-1050]
----
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
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F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
---
Y
---
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
------
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
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D
R
E
R
F
Q
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L
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L
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A
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A
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T
A
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A
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A
K
E
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Y
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L
V
V
R
P
S
Y
V
L
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G
R
A
M
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Y
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E
A
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L
R
R
Y
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A
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V
S
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V
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
-
G
E
M
V
L
I
G
G
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M
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H
I
E
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A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
-
R
G
L
M
N
V
Q
F
A
V
K
N
--
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
--
K
----
E
V
I
---
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
----------------
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
T
A
I
V
L
G
E
------
A
G
I
N
P
R
L
V
N
K
V
H
E
GRPH
I
-
Q
D
R
I
K
N
G
E
Y
T
-
Y
--
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
---------------
V
H
Y
D
T
T
L
N
G
G
F
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
44.11
31%
-67
- C1 -
-
1A9X
-
CARB_ECOLI
E:
[557-1050]
----
T
D
R
E
K
I
M
V
L
G
G
G
P
N
R
I
G
Q
G
I
E
F
D
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
T
D
---
Y
---
D
T
S
D
R
L
Y
F
E
P
V
T
L
E
D
V
L
E
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
P
L
K
L
------
A
R
A
L
E
A
A
G
V
P
V
I
G
T
S
P
D
A
I
D
R
A
E
D
R
E
R
F
Q
H
A
V
E
R
L
K
L
K
Q
P
A
N
A
T
V
T
A
I
E
M
A
V
E
K
A
K
E
I
G
Y
P
L
V
V
R
A
-------
A
M
E
I
V
Y
D
E
A
D
L
R
R
Y
F
Q
T
A
V
--------
L
L
D
H
F
L
D
D
A
V
E
V
D
V
D
A
I
C
D
-
G
E
M
V
L
I
G
G
I
M
E
H
I
E
Q
A
G
V
H
S
G
D
S
A
C
S
L
P
A
Y
T
L
S
Q
E
I
Q
D
V
M
R
Q
Q
V
Q
K
L
A
F
E
L
Q
V
-
R
G
L
M
N
V
Q
F
A
V
K
N
--
N
E
V
Y
L
I
E
V
N
P
R
A
A
R
T
V
P
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
--
K
----
E
V
---
I
P
P
Y
Y
S
V
K
E
V
V
L
P
F
N
K
F
P
G
V
D
P
L
L
G
P
E
M
R
S
T
G
E
V
M
G
V
G
R
T
F
A
E
A
F
A
K
A
Q
L
G
S
N
S
T
M
K
K
H
G
----------------
R
A
L
L
S
V
R
E
G
D
K
E
R
V
V
D
L
A
A
K
L
L
K
Q
G
F
E
L
D
A
T
H
G
------
T
AIVLGE
A
G
I
N
P
R
L
V
N
K
V
H
E
----
G
R
P
H
I
Q
D
R
I
K
N
G
E
Y
T
Y
I
I
N
T
T
S
G
R
R
A
I
E
D
S
R
V
I
R
R
S
A
L
Q
Y
K
---------------
V
H
Y
D
T
T
L
N
G
G
F
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
42.41
28%
-103
- C1 -
-
5DOU
-
CPSM_HUMAN
D:
[960-1350]
----
F
D
D
H
G
M
M
V
L
G
C
G
P
Y
H
I
G
S
S
V
E
F
D
W
C
A
V
S
S
I
R
T
L
R
Q
L
G
K
K
T
V
V
V
N
C
N
P
E
T
V
S
T
D
---
F
---
D
E
C
D
K
L
Y
F
E
E
L
S
L
E
R
I
L
D
I
Y
H
Q
E
A
C
G
G
C
I
I
S
V
G
G
Q
I
P
N
N
L
------
A
V
P
L
Y
K
N
G
V
K
I
M
G
T
S
P
L
Q
I
D
R
A
E
D
R
S
I
F
S
A
V
L
D
E
L
K
V
A
Q
A
P
W
K
A
V
N
T
L
N
E
A
L
E
F
A
K
S
V
D
Y
P
C
L
L
R
---------
M
N
V
V
F
S
E
D
E
M
K
K
F
L
--------
E
H
P
V
V
L
T
K
F
V
E
G
A
R
E
V
E
M
D
A
V
G
K
-
D
G
R
V
I
S
H
A
I
S
E
H
V
E
D
A
G
V
H
S
G
D
A
T
L
M
L
P
T
Q
T
I
S
Q
G
A
I
E
K
V
K
D
A
T
R
K
I
A
K
A
F
A
I
-
S
G
P
F
N
V
Q
F
L
V
K
G
--
N
D
V
L
V
I
E
C
N
L
R
A
S
R
S
F
P
F
V
S
K
T
L
G
V
D
F
I
D
V
A
T
K
V
M
I
G
E
N
V
D
E
K
H
L
P
T
-
L
---
D
H
P
I
I
P
-
A
D
Y
V
A
I
K
A
P
M
F
S
W
P
R
L
R
D
A
D
P
I
L
R
C
E
M
A
S
T
G
E
V
A
C
F
G
E
G
I
H
T
A
F
L
K
A
M
L
S
T
G
F
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
40.13
85%
-145
- C1 -
-
1A9X
-
CARB_ECOLI
A:
[1-142]
M
P
K
R
T
D
I
K
S
I
L
I
L
G
A
G
P
I
V
I
G
Q
A
C
E
F
D
Y
S
G
A
Q
A
C
K
A
L
R
E
E
G
Y
R
V
I
N
V
N
S
N
P
A
T
I
M
T
D
---
P
---
E
M
A
D
A
T
Y
I
E
P
I
H
W
E
V
V
R
K
I
I
E
K
E
R
P
D
A
V
L
P
T
M
G
G
Q
T
A
L
N
C
A
L
E
L
E
R
Q
G
V
L
E
E
F
G
V
T
M
I
G
A
T
A
D
A
I
D
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------