@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT96: (2017-12-12 )
MTLSCIQQPHQHLQANLEGGVLTLAINRPEAKNALYGELYLWIAKALDEADQNKDVRAVVLRGAEHDFTAGNDMKDFMGFVQNPNAGPAGQVPPFVLLKSAARLSKPLIIAVKGVAIGIGVTILLQADLVFADNTALFQIPFVSLGLSPEGGASQLLVKQAGYHKATELLFTAKKFNAEAAVQAGLVNEIVEDAYATAQHLTALPLASLKQTKALMKHDLDQIIECIDHETEIFMQRVQSPEMLEAVQAFMQKRKPDFSQFNGFVAQTF
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70----.......----.80..-.--.....90...-------.....100.......110.......120.......130.......140.......150.......160.......170.......180.....------..190----.------.------.------.------.....200.-...---...210.-.....-.220.-......-.230........240.......250.......260.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
L
S
C
I
QQ
P
H
Q
H
L
Q
A
NLEG
G
V
L
T
L
A
INRPEAKN
A
L
Y
G
E
L
Y
L
W
I
A
K
A
LDEADQNKD
V
R
A
V
V
L
RGAEHDFTAG----N
D
M
K
D
F
M
----
G
F
VQN-P--NAGPAGQV
P
P
-------
F
V
L
L
K
S
A
A
RLSK
P
L
I
I
A
V
KG
V
A
I
G
I
G
V
T
I
L
L
Q
A
D
L
V
FADN
T
A
L
F
Q
I
P
F
V
SLGLSPEGG
A
S
Q
L
L
V
K
QAG
Y
H
K
A
T
E
L
L
F
T
A
K
KF
N
A
E
A
A
V
Q
A
G
L
V
------
N
E
I
------
V
------
E
------
D
------
A
------
Y
A
T
A
Q
H
L
T
A-L
P
L
---
A
S
L
K
Q
T
K
-
A
L
M
K
H
-
D
L
D
-
Q
-
I
I
E
C
ID-
H
E
-
T
E
I
F
M
Q
R
VQS
P
E
M
L
E
A
V
Q
A
F
M
Q
KRKP
D
F
S
Q
F
N
G
F
VAQTF
80
HHSearch
89.45
95%
-102
- C3 -
-
3FDU
1
?
A:
[3-249]
--------
L
H
P
H
L
N
A
N
L
E
G
G
V
L
T
L
A
I
N
R
P
E
A
K
N
A
L
Y
G
E
L
Y
L
W
I
A
K
A
L
D
E
A
D
Q
N
K
D
V
R
V
V
V
L
R
G
A
E
H
D
F
T
A
G
----
N
D
M
K
D
F
M
----
G
F
V
Q
N
-
P
--
N
A
G
P
A
G
Q
V
P
P
-------
F
V
L
L
K
S
A
A
R
L
S
K
P
L
I
I
A
V
K
G
V
A
I
G
I
G
V
T
I
L
L
Q
A
D
L
V
F
A
D
N
T
A
L
F
Q
I
P
F
V
S
L
G
L
S
P
E
G
G
A
S
Q
L
L
V
K
Q
A
G
Y
H
K
A
A
E
L
L
F
T
A
K
K
F
N
A
E
T
A
L
Q
A
G
L
V
------
N
E
I
------
V
------
E
D
A
Y
A
--
T
------
A
------
Q
A
T
A
Q
H
L
T
A
-
L
P
L
---
A
S
L
K
Q
T
K
-
A
L
M
K
H
-
D
L
D
-
Q
-
I
I
E
C
I
D
-
H
E
-
A
E
I
F
M
Q
R
V
Q
S
P
E
M
L
E
A
V
Q
A
F
M
------------------
1
PsiBlast_PDB
89.22
94%
-101
- C3 -
-
3FDU
1
?
A:
[4-249]
---------
H
P
H
L
N
A
N
L
E
G
G
V
L
T
L
A
I
N
R
P
E
A
K
N
A
L
Y
G
E
L
Y
L
W
I
A
K
A
L
D
E
A
D
Q
N
K
D
V
R
V
V
V
L
R
G
A
E
H
D
F
T
A
G
----
N
D
M
K
D
F
M
----
G
F
V
Q
N
-
P
--
N
A
G
P
A
G
Q
V
P
P
-------
F
V
L
L
K
S
A
A
R
L
S
K
P
L
I
I
A
V
K
G
V
A
I
G
I
G
V
T
I
L
L
Q
A
D
L
V
F
A
D
N
T
A
L
F
Q
I
P
F
V
S
L
G
L
S
P
E
G
G
A
S
Q
L
L
V
K
Q
A
G
Y
H
K
A
A
E
L
L
F
T
A
K
K
F
N
A
E
T
A
L
Q
A
G
L
V
------
N
E
I
------
V
------
E
------
D
A
Y
A
T
--
A
------
Q
A
T
A
Q
H
L
T
A
-
L
P
L
---
A
S
L
K
Q
T
K
-
A
L
M
K
H
-
D
L
D
-
Q
-
I
I
E
C
I
D
-
H
E
-
A
E
I
F
M
Q
R
V
Q
S
P
E
M
L
E
A
V
Q
A
F
M
------------------
2
PsiBlast_PDB
65.34
35%
-94
- C3 -
-
5VE2
-
?
A:
[25-275]
----------
K
S
L
N
V
S
L
N
N
R
V
L
S
L
T
I
N
R
P
E
L
K
N
A
L
N
R
E
L
Y
A
A
L
A
D
E
L
E
R
S
N
H
D
D
Q
I
R
A
V
L
L
T
A
N
G
D
T
F
T
A
G
----
N
D
L
D
D
F
I
----
N
P
V
E
E
--------
S
G
T
P
S
V
-------
I
R
F
L
K
A
I
S
E
C
E
T
P
I
V
V
A
V
N
G
P
A
I
G
V
G
L
T
M
L
L
H
C
D
M
V
Y
A
S
K
S
A
R
F
R
A
P
F
T
H
V
G
L
V
P
E
A
A
S
S
L
L
L
P
L
A
V
G
Q
A
W
A
N
D
L
M
L
A
G
R
I
L
D
A
R
E
A
L
S
A
G
L
V
------
T
R
V
------
F
------
E
------
D
DV
L
V
A
E
S
------
L
K
I
A
E
Q
V
A
S
-
L
A
P
---
N
S
V
K
Q
S
K
-
R
L
I
R
G
V
N
K
E
-
E
-
V
Q
A
Q
M
K
-
R
E
-
G
V
I
F
A
E
Q
L
A
S
A
E
F
K
E
S
V
A
A
F
F
E
K
R
A
P
H
F
A
----------
5
PsiBlast_PDB
61.99
38%
-114
- C3 -
-
3QMJ
2
?
A:
[8-216]
------------
L
Q
I
D
D
D
N
R
V
R
T
L
T
L
N
R
P
E
A
L
N
A
F
N
E
A
L
Y
D
A
T
A
Q
A
L
L
D
A
A
D
D
P
Q
V
A
V
V
L
L
T
G
S
G
R
G
F
S
A
G
----
T
D
L
A
E
M
Q
----
A
R
I
T
D
-
P
--
N
F
S
-
E
G
K
F
G
F
-------
R
G
L
I
K
A
L
A
G
F
P
K
P
L
I
C
A
V
N
G
L
G
V
G
I
G
A
T
I
L
G
Y
A
D
L
A
F
M
S
S
T
A
R
L
K
C
P
F
T
S
L
---
P
E
A
A
S
S
Y
L
L
P
Q
L
V
G
R
Q
N
A
A
W
L
L
M
S
S
E
W
I
D
A
E
E
A
L
R
M
G
L
V
W
R
I
C
S
P
E
E
L
------
L
------
P
------
E
------
A
------
R
R
H
A
E
I
L
A
A
-
K
P
I
---
S
S
L
M
A
V
K
-
H
T
M
----------------------------------------------------------
93
HHSearch
60.59
31%
-94
- C3 -
-
2PBP
-
?
A:
[4-257]
---------
F
V
S
I
A
A
R
Q
E
G
A
V
G
I
I
E
L
A
R
P
D
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
R
A
F
A
A
G
----
A
D
I
Q
E
M
A
----
K
D
D
P
I
----
R
---
L
E
W
L
N
Q
-------
F
A
D
W
D
R
L
S
I
V
K
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
L
T
K
L
I
G
P
K
R
A
L
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
------
N
R
V
------
V
------
S
PEL
L
M
E
E
------
T
------
M
R
L
A
G
R
L
A
E
-
Q
P
P
---
L
A
L
R
L
I
K
-
E
A
V
Q
K
-
A
V
D
Y
P
-
L
Y
E
G
M
Q
-
F
E
-
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
Q
G
---------
92
HHSearch
60.55
31%
-94
- C3 -
-
2QQ3
1
?
K:
[3-257]
--------
E
F
V
S
I
A
A
R
Q
E
G
A
V
G
I
I
E
L
A
R
P
D
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
R
A
F
A
A
G
----
A
D
I
Q
E
M
A
----
K
D
D
P
I
----
R
---
L
E
W
L
N
Q
-------
F
A
D
W
D
R
L
S
I
V
K
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
L
T
K
L
I
G
P
K
R
A
L
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
------
N
R
V
------
V
------
S
PELLME
E
------
T
------
M
R
L
A
G
R
L
A
E
-
Q
P
P
---
L
A
L
R
L
I
K
-
E
A
V
Q
K
-
A
V
D
Y
P
-
L
Y
E
G
M
Q
-
F
E
-
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
Q
G
---------
6
PsiBlast_PDB
59.73
30%
-92
- C3 -
-
2PBP
-
?
A:
[6-255]
-----------
S
I
A
A
R
Q
E
G
A
V
G
I
I
E
L
A
R
P
D
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
R
A
F
A
A
G
----
A
D
I
Q
E
--------
M
A
K
-
D
--
D
P
I
R
L
E
W
L
N
Q
-------
F
A
D
W
D
R
L
S
I
V
K
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
L
T
K
L
I
G
P
K
R
A
L
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
------
N
R
V
------
V
S
PEL
L
M
E
------
E
------
T
------
M
R
L
A
G
R
L
A
E
-
Q
P
P
---
L
A
L
R
L
I
K
-
E
A
V
Q
K
-
A
V
D
-
Y
P
L
Y
E
G
M
Q
-
F
E
-
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
-----------
3
PsiBlast_PDB
59.28
37%
-91
- C3 -
-
4NEK
1
?
A:
[7-252]
--------------
S
H
V
E
G
G
V
Q
V
V
R
M
N
R
P
D
K
K
N
A
L
I
G
E
M
Y
A
A
L
A
E
A
F
A
K
G
E
A
D
D
D
V
N
V
F
L
I
L
G
S
Q
T
D
F
S
A
G
----
N
D
L
P
D
F
L
----
T
W
-------
E
A
L
S
G
S
V
A
D
R
-------
F
I
R
A
V
A
G
A
R
--
K
P
V
V
A
A
V
R
G
A
A
I
G
I
G
S
T
L
L
P
H
C
D
L
V
Y
A
A
P
G
T
R
F
H
M
P
F
I
N
L
G
I
V
P
E
A
G
S
S
Q
T
M
P
A
L
A
G
H
R
R
A
A
E
M
L
M
L
G
E
P
F
G
V
D
T
A
E
A
V
G
L
I
------
N
G
V
------
V
P
GED
L
E
E
------
T
------
A
------
M
A
A
A
R
K
L
A
A
-
K
P
R
---
S
I
L
V
Q
I
K
-
A
L
M
K
T
-
P
A
E
-
P
-
I
M
D
R
L
T
-
R
E
-
A
A
V
F
D
T
C
L
K
G
E
A
L
N
E
A
V
S
A
F
K
E
K
R
A
P
D
F
S
K
---------
4
PsiBlast_PDB
58.85
35%
-95
- C3 -
-
3HRX
-
?
A:
[9-251]
-------------------
G
V
L
V
L
T
L
N
R
P
E
K
L
N
A
I
T
G
E
L
L
D
A
L
Y
A
A
L
K
E
G
E
E
D
R
E
V
R
A
L
L
L
T
G
A
G
R
A
F
S
A
G
----
Q
D
L
T
E
F
G
----
D
--
R
K
-
P
--
D
Y
E
A
H
L
R
R
Y
N
-------
R
V
V
-
E
A
L
S
G
L
E
K
P
L
V
V
A
V
N
G
V
A
A
G
A
G
M
S
L
A
L
W
G
D
L
R
L
A
A
V
G
A
S
F
T
T
A
F
V
R
I
G
L
V
P
D
S
G
L
S
F
L
L
P
R
L
V
G
L
A
K
A
Q
E
L
L
L
L
S
P
R
L
S
A
E
E
A
L
A
L
G
L
V
------
H
R
V
------
V
PAEK
L
M
E
------
E
------
A
------
L
S
L
A
K
E
L
A
Q
-
G
P
T
---
R
A
Y
A
L
T
K
-
K
L
L
L
E
-
T
Y
R
L
S
-
L
T
E
A
L
A
-
L
E
-
A
V
L
Q
G
Q
A
G
Q
T
Q
D
H
E
E
G
V
R
A
F
R
E
K
R
P
P
R
F
-----------
19
PsiBlast_PDB
58.66
31%
-91
- C3 -
-
3SWX
-
?
A:
[8-262]
---------
Y
E
T
L
R
I
R
R
D
G
Y
V
L
V
I
G
L
N
R
P
A
K
R
N
A
F
D
K
T
M
L
E
E
L
A
L
A
L
G
E
Y
E
T
D
T
D
L
R
A
A
V
L
Y
G
E
G
P
L
F
T
A
G
----
L
D
L
A
S
V
A
----
A
E
I
Q
--
A
--
S
L
T
P
E
G
G
I
N
P
-------
W
Q
V
--
D
G
R
Q
L
S
K
P
L
L
V
A
V
H
G
K
V
L
T
L
G
I
E
L
A
L
A
A
D
I
V
I
A
D
E
T
A
T
F
A
Q
L
E
V
N
R
G
I
Y
P
F
G
G
A
T
I
R
F
P
R
T
A
G
W
G
N
A
M
R
W
M
L
T
A
D
T
F
D
A
V
E
A
H
R
I
G
I
V
------
Q
E
I
V
P
V
GE
H
V
------
D
------
T
------
A
------
I
A
I
A
Q
T
I
A
R
Q
A
P
L
G
V
Q
A
T
L
R
N
A
R
L
A
V
R
E
G
-
D
A
A
-
A
-
E
E
Q
L
V
P
-
T
V
-
R
E
L
F
T
----
S
E
D
A
T
L
G
V
Q
A
F
L
S
R
T
T
A
E
F
-----------
89
HHSearch
58.53
25%
-116
- C3 -
-
4MOU
-
?
C:
[34-294]
---------
T
G
R
I
S
V
A
I
A
D
G
V
A
S
V
E
I
S
N
L
A
Q
R
N
A
L
T
K
D
M
C
L
E
I
Q
E
L
M
P
Q
L
D
A
D
P
D
V
A
V
V
V
L
R
G
A
G
D
T
F
C
A
G
----
A
S
I
S
E
L
A
----
S
V
L
L
D
-
P
--
Q
P
D
G
S
T
A
D
H
L
-------
S
R
A
D
S
A
I
A
A
L
S
K
P
A
V
A
L
V
D
G
A
C
M
G
G
G
W
Q
I
A
S
A
C
D
F
I
I
A
N
E
R
A
V
I
G
L
T
P
A
K
I
G
I
I
Y
P
R
P
G
L
E
R
L
V
R
L
V
G
H
A
N
A
K
Y
I
L
L
T
G
Q
T
F
S
A
P
E
A
R
A
L
G
L
V
------
A
D
V
------
V
------
P
SESFEE
K
------
C
------
A
A
L
V
R
S
L
R
S
-
R
S
R
---
F
S
M
H
S
M
K
-
R
L
V
D
L
-
T
D
S
-----
A
G
I
D
-
Q
E
W
A
A
A
W
S
A
M
P
D
S
P
D
M
G
I
G
I
S
A
F
L
N
R
E
Q
P
R
F
M
W
R
P
A
------
7
PsiBlast_PDB
58.43
30%
-90
- C3 -
-
2QQ3
1
?
A:
[6-255]
-----------
S
I
A
A
R
Q
E
G
A
V
G
I
I
E
L
A
R
P
D
V
L
N
A
L
S
R
Q
M
V
A
E
I
V
A
A
V
E
A
F
D
R
N
E
K
V
R
V
I
V
L
T
G
R
G
R
A
F
A
A
G
----
A
D
I
Q
E
--------
M
A
K
-
D
--
D
P
I
R
L
E
W
L
N
Q
-------
F
A
D
W
D
R
L
S
I
V
K
T
P
M
I
A
A
V
N
G
L
A
L
G
G
G
F
E
L
A
L
S
C
D
L
I
V
A
S
S
A
A
E
F
G
F
P
E
V
N
L
G
V
M
P
G
A
G
G
T
Q
R
L
T
K
L
I
G
P
K
R
A
L
E
W
L
W
T
G
A
R
M
S
A
K
E
A
E
Q
L
G
I
V
------
N
R
V
------
V
SPEL
L
M
E
------
E
------
T
------
M
R
L
A
G
R
L
A
E
-
Q
P
P
---
L
A
L
R
L
I
K
-
E
A
V
Q
K
-
A
V
D
-
Y
P
L
Y
E
G
M
Q
-
F
E
-
R
K
N
F
Y
L
L
F
A
S
E
D
Q
K
E
G
M
A
A
F
L
E
K
R
K
P
R
F
-----------
91
HHSearch
57.85
28%
-59
- C3 -
-
4JFC
1
?
A:
[25-281]
----------
G
A
I
K
S
T
S
E
G
Q
T
L
I
L
T
L
S
N
P
E
F
R
N
A
L
G
P
E
I
Y
A
A
G
I
E
A
L
N
A
A
E
N
N
P
E
I
R
S
V
V
I
T
G
E
G
A
V
F
C
A
G
----
G
N
L
Q
R
L
Q
----
A
N
R
R
E
-
A
P
-
E
V
Q
A
Q
S
I
E
G
L
-------
H
N
W
I
D
S
I
R
T
Y
P
K
P
V
I
A
A
V
E
G
A
A
A
G
A
G
F
S
L
A
L
A
C
D
F
V
V
A
A
S
N
A
V
F
V
M
S
Y
S
T
V
G
L
S
P
D
G
G
G
S
W
S
L
A
R
S
L
P
R
A
L
A
S
E
L
L
M
G
G
E
R
I
S
A
Q
R
L
H
D
L
G
L
V
------
N
K
V
------
A
------
S
AGD
A
L
S
E
------
A
------
L
R
M
A
G
Q
L
N
A
-
R
A
P
---
N
A
L
A
S
I
K
-
E
L
I
N
E
-
A
S
S
N
T
-
L
S
Q
Q
L
A
-
C
E
-
R
D
H
F
V
R
N
L
H
H
S
N
G
G
E
G
I
A
A
F
L
G
K
R
T
P
Q
Y
R
----------
37
PsiBlast_CBE
57.61
31%
-69
- C3 -
-
3SWX
1
?
B:
[8-262]
---------
Y
E
T
L
R
I
R
R
D
G
Y
V
L
V
I
G
L
N
R
P
A
K
R
N
A
F
D
K
T
M
L
E
E
L
A
L
A
L
G
E
Y
E
T
D
T
D
L
R
A
A
V
L
Y
G
E
G
P
L
F
T
A
G
----
L
D
L
A
S
V
A
----
A
E
I
Q
G
G
A
--
S
L
T
P
E
G
G
I
N
P
-------
W
Q
V
--
D
G
R
Q
L
S
K
P
L
L
V
A
V
H
G
K
V
L
T
L
G
I
E
L
A
L
A
A
D
I
V
I
A
D
E
T
A
T
F
A
Q
L
E
V
N
R
G
I
Y
P
F
G
G
A
T
I
R
F
P
R
T
A
G
W
G
N
A
M
R
W
M
L
T
A
D
T
F
D
A
V
E
A
H
R
I
G
I
V
------
Q
E
I
V
P
VGE
H
V
------
D
------
T
------
A
------
I
A
I
A
Q
T
I
A
R
Q
A
P
L
G
V
Q
A
T
L
R
N
A
R
L
A
V
R
E
G
-
D
A
A
-
A
-
E
E
Q
L
V
P
-
T
V
-
R
E
L
F
T
----
S
E
D
A
T
L
G
V
Q
A
F
L
S
R
T
T
A
E
F
-----------
36
PsiBlast_CBE
57.51
31%
-70
- C3 -
-
3SWX
1
?
C:
[8-262]
---------
Y
E
T
L
R
I
R
R
D
G
Y
V
L
V
I
G
L
N
R
P
A
K
R
N
A
F
D
K
T
M
L
E
E
L
A
L
A
L
G
E
Y
E
T
D
T
D
L
R
A
A
V
L
Y
G
E
G
P
L
F
T
A
G
----
L
D
L
A
S
V
A
----
A
E
I
Q
G
G
A
--
S
L
T
P
E
G
G
I
N
P
-------
W
Q
V
--
D
G
R
Q
L
S
K
P
L
L
V
A
V
H
G
K
V
L
T
L
G
I
E
L
A
L
A
A
D
I
V
I
A
D
E
T
A
T
F
A
Q
L
E
V
N
R
G
I
Y
P
F
G
G
A
T
I
R
F
P
R
T
A
G
W
G
N
A
M
R
W
M
L
T
A
D
T
F
D
A
V
E
A
H
R
I
G
I
V
------
Q
E
I
VPVGEH
V
------
D
------
T
------
A
------
I
A
I
A
Q
T
I
A
R
Q
A
P
L
GVQ
A
T
L
R
N
A
R
L
A
V
R
E
G
-
D
A
A
-
A
-
E
E
Q
L
V
P
-
T
V
-
R
E
L
F
T
----
S
E
D
A
T
L
G
V
Q
A
F
L
S
R
T
T
A
E
F
-----------
90
HHSearch
57.38
25%
-109
- C3 -
-
4MOU
-
?
A:
[32-294]
-------
P
R
T
G
R
I
S
V
A
I
A
D
G
V
A
S
V
E
I
S
N
L
A
Q
R
N
A
L
T
K
D
M
C
L
E
I
Q
E
L
M
P
Q
L
D
A
D
P
D
V
A
V
V
V
L
R
G
A
G
D
T
F
C
A
G
----
A
S
I
S
E
L
A
----
S
V
L
L
D
-
P
--
Q
P
D
G
S
T
A
D
H
L
-------
S
R
A
D
S
A
I
A
A
L
S
K
P
A
V
A
L
V
D
G
A
C
M
G
G
G
W
Q
I
A
S
A
C
D
F
I
I
A
N
E
R
A
V
I
G
L
T
P
A
K
I
G
I
I
Y
P
R
P
G
L
E
R
L
V
R
L
V
G
H
A
N
A
K
Y
I
L
L
T
G
Q
T
F
S
A
P
E
A
R
A
L
G
L
V
------
A
D
V
------
V
------
P
SES
F
E
E
K
------
C
------
A
A
L
V
R
S
L
R
S
-
R
S
R
---
F
S
M
H
S
M
K
-
R
L
V
D
L
-
T
D
S
------
G
I
D
-
Q
E
W
A
A
A
W
S
A
M
P
D
S
P
D
M
G
I
G
I
S
A
F
L
N
R
E
Q
P
R
F
M
W
R
P
A
------
75
HHSearch
56.82
22%
-121
- C3 -
-
4NNQ
-
?
B:
[12-257]
----------
R
G
V
R
L
T
A
E
P
H
V
L
R
A
T
L
T
S
P
D
G
L
N
S
L
S
G
A
A
L
D
A
L
G
A
A
L
D
R
A
E
A
D
P
E
C
R
V
L
L
L
E
G
S
G
G
T
F
C
T
G
----
L
D
----------------------
R
G
G
A
E
F
-------
L
A
L
M
R
R
F
G
E
T
P
L
A
V
V
A
C
V
D
G
R
A
A
G
G
G
V
G
L
A
A
A
A
D
L
V
I
A
T
E
R
S
E
F
S
L
P
E
A
L
W
G
L
V
P
C
C
-
V
L
P
V
L
V
R
R
T
G
F
Q
P
A
Y
A
M
A
L
S
T
Q
P
V
S
A
R
R
A
A
D
F
R
L
V
------
D
E
V
------
V
------
P
D
P
D
A
--
A
------
V
------
R
R
L
L
V
R
L
T
R
-
L
D
P
---
A
T
I
G
E
L
K
-
Q
Y
F
R
A
-
M
W
F
-
T
-
T
E
D
T
D
A
-
F
A
-
L
R
E
F
T
R
L
I
D
S
P
V
A
R
R
R
I
T
D
Y
T
T
-----------------
79
HHSearch
56.43
29%
-95
- C3 -
-
3SWX
1
?
B:
[7-264]
--------
D
Y
E
T
L
R
I
R
R
D
G
Y
V
L
V
I
G
L
N
R
P
A
K
R
N
A
F
D
K
T
M
L
E
E
L
A
L
A
L
G
E
Y
E
T
D
T
D
L
R
A
A
V
L
Y
G
E
G
P
L
F
T
A
G
----
L
D
L
A
S
V
A
----
A
E
I
Q
G
-
G
--
A
S
-
L
T
P
E
G
G
I
-------
N
P
W
Q
V
D
G
R
Q
L
S
K
P
L
L
V
A
V
H
G
K
V
L
T
L
G
I
E
L
A
L
A
A
D
I
V
I
A
D
E
T
A
T
F
A
Q
L
E
V
N
R
G
I
Y
P
F
G
G
A
T
I
R
F
P
R
T
A
G
W
G
N
A
M
R
W
M
L
T
A
D
T
F
D
A
V
E
A
H
R
I
G
I
V
------
Q
E
I
------
V
------
P
VGE
H
V
D
T
------
A
------
I
A
I
A
Q
T
I
A
R
-
Q
A
P
---
L
G
V
Q
A
T
L
-
R
N
A
R
L
-
A
V
R
E
G
-
D
A
A
A
E
E
-
Q
L
-
V
P
T
V
R
E
L
F
T
S
E
D
A
T
L
G
V
Q
A
F
L
S
R
T
T
A
E
F
V
G
---------
88
HHSearch
56.36
31%
-53
- C3 -
-
4FZW
-
PAAG_ECOLI
D:
[16-274]
-----------
F
I
L
S
H
V
E
K
G
V
M
T
L
T
L
N
R
P
E
R
L
N
S
F
N
D
E
M
H
A
Q
L
A
E
C
L
K
Q
V
E
R
D
D
T
I
R
C
L
L
L
T
G
A
G
R
G
F
C
A
G
----
Q
D
L
N
--------------AP
D
L
G
M
S
V
E
R
F
Y
-------
N
P
L
V
R
R
L
A
K
L
P
K
P
V
I
C
A
V
N
G
V
A
A
G
A
G
A
T
L
A
L
G
G
D
I
V
I
A
A
R
S
A
K
F
V
M
A
F
S
K
L
G
L
I
P
D
C
G
G
T
W
L
L
P
R
V
A
G
R
A
R
A
M
G
L
A
L
L
G
N
Q
L
S
A
E
Q
A
H
E
W
G
M
I
------
W
Q
V
------
V
------
D
DETLAD
T
------
A
------
Q
Q
L
A
R
H
L
A
T
-
Q
P
T
---
F
G
L
G
L
I
K
-
Q
A
I
N
S
-
A
E
T
N
T
-
L
D
T
Q
L
D
-
L
E
-
R
D
Y
Q
R
L
A
G
R
S
A
D
Y
R
E
G
V
S
A
F
L
A
K
R
S
P
Q
F
T
G
K
--------
10
PsiBlast_PDB
56.18
28%
-79
- C3 -
-
4LK5
-
?
A:
[11-258]
--------
P
V
A
G
L
D
V
T
L
S
D
G
V
F
S
V
T
I
N
R
P
D
S
L
N
S
L
T
V
P
V
I
T
G
I
A
D
A
M
E
Y
A
A
T
D
P
E
V
K
V
V
R
I
G
G
A
G
R
G
F
S
S
G
AGIS----------------------------
P
P
D
E
I
I
L
E
I
N
R
L
V
R
A
I
A
A
L
P
H
P
V
V
A
V
V
Q
G
P
A
A
G
V
G
V
S
I
A
L
A
C
D
V
V
L
A
S
E
N
A
F
F
M
L
A
F
T
K
I
G
L
M
P
D
G
G
A
S
A
L
V
A
A
A
V
G
R
I
R
A
M
Q
M
A
L
L
P
E
R
L
P
A
A
E
A
L
A
W
G
L
V
TAVYPA
D
E
F
------
E
------
A
------
E
------
V
------
D
K
V
I
A
R
L
L
S
-
G
P
A
---
V
A
F
A
K
T
K
L
A
I
N
A
A
-
T
L
T
-
E
-
L
D
P
A
L
Q
-
R
E
-
F
D
G
Q
S
V
L
L
K
S
P
D
F
V
E
G
A
T
A
--------------------
8
PsiBlast_PDB
52.06
31%
-43
- C3 -
-
4U18
1
ECI2_HUMAN
A:
[33-271]
-----------------
E
D
G
I
T
K
I
M
F
N
R
P
K
K
K
N
A
I
N
T
E
M
Y
H
E
I
M
R
A
L
K
A
A
S
K
D
D
S
I
-
I
T
V
L
T
G
N
G
D
Y
Y
S
S
G
----
N
D
L
T
N
F
T
DIPP
G
G
V
E
E
-
K
--
A
K
N
N
A
V
L
L
R
E
-------
F
V
--
G
C
F
I
D
F
P
K
P
L
I
A
V
V
N
G
P
A
V
G
I
S
V
T
L
L
G
L
F
D
A
V
Y
A
S
D
R
A
T
F
H
T
P
F
S
H
L
G
Q
S
P
E
G
C
S
S
Y
T
F
P
K
I
M
S
P
A
K
A
T
E
M
L
I
F
G
K
K
L
T
A
G
E
A
C
A
Q
G
L
V
------
T
E
V
------
F
------
P
------
D
------
S
T
F
Q
K
E
V
W
T
R
L
K
A
F
A
K
-
L
P
P
---
N
A
L
R
I
S
K
-
E
V
I
R
K
-
R
E
R
-
E
-
K
L
H
A
V
N
A
E
E
-
C
N
V
L
Q
G
R
W
L
S
D
E
C
T
N
A
V
V
---------------------