@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U031: (2017-12-17 )
MMELQFPLHNDTSRKIIHIDMDAFFASVEERDHPEFRGHPLVIARHPSDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKPRGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTRERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQASLIWEEILGVEKGIRLLGITLTNLDPMTYENIVLPLWENQEI
Atome Classification :
(29 SA)
-------------------------------------------------------.........10........20........30........40........50.----.......60........70........80........90........100.......110.......120.......--130.--------------------.......140.......150.......160.......170.......180-........190.......200.......210.......220.......230-.-......240.......250.......260......---.270......-----.280.......290.--......300.......310.......320.......330.......----340..----......350.......360.......370.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------------------------M
M
E
L
Q
FPLHNDTS
R
K
I
I
H
I
D
M
D
A
F
F
A
S
V
E
ERDHPEFRG
H
P
L
V
I
A
RHPSDTGG----
R
G
V
V
T
TANY
E
A
R
K
F
G
I
H
S
A
M
S
A
Q
K
A
Y
E
L
C
P
Q
A
IFKPGDHH
K
Y
S
D
I
S
K
Q
V
R
E
V
F
Y
R
Y
T
DIVEPVSI
D
E
A
Y
L
DVTENKI--N
C
-
K
--------------------
S
A
I
K
I
A
R
M
I
Q
A
D
I
W
E
S
V
Q
L
T
CSAGV
S
Y
N
K
F
L
A
K
L
A
S
D
YQKPR
G
I
T
V
VAP--QDA
V
P
F
L
K
ALP
I
E
K
F
HGVGKK
T
V
P
R
M
H
ELGIYT
G
K
D
L
Y
E
C
T
E
M
M
L
I
R
N
F
G
K
-
M
-
G
Y
S
L
Y
R
K
V
RGIHDSPV
N
V
T
R
E
R
K
SVGKEHTYGQPL---
Q
T
E
E
A
V
L
T
Q
L
-----
R
Q
L
A
E
K
V
E
E
A
L
R
R
V
Q
--KHG
K
T
V
V
L
K
V
R
YTDY
S
T
V
TKRVT
L
P
E
Y
I
Y
K
K
E
A
L
F
Y
Q
A
S
L
I
W
E
E
I
L
----
G
-
V
E
K----G
I
R
L
L
G
I
T
LTNLDPMTYE
N
I
V
L
PLWENQEI
34
HHSearch
83.28
41%
-98
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
---
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
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A
M
P
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G
M
A
L
A
L
C
P
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T
L
L
P
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A
Y
K
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A
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N
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T
S
R
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P
L
S
L
D
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A
Y
L
D
V
T
D
S
V
H
--
C
H
-
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
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A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
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I
D
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R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
---
H
H
W
S
E
C
E
A
I
I
-----
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
--
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
------
G
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
37
HHSearch
79.40
40%
-93
- C1 -
-
5C5J
5
?
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
---
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
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I
F
S
R
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T
S
R
I
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P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
--
C
H
-
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
---
H
H
W
S
E
C
E
A
I
I
-----
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
PD
L
L
I
A
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
--
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
------
G
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
39
HHSearch
70.56
28%
-83
- C1 -
-
4TQR
4
DPO4_SULSO
A:
[1-342]
--------------------------------------------------------------------
M
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
----
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
--
D
Y
-
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
---
R
N
L
E
E
I
K
P
Y
L
-----
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
-
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
----
E
E
D
E
R
----
K
I
R
R
I
G
V
R
F
S
K
F
I
E
----------------
38
HHSearch
70.33
28%
-85
- C1 -
-
3RAX
3
DPO4_SULSO
B:
[1-341]
--------------------------------------------------------------------
G
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
----
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
--
D
Y
-
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
-
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
---
R
N
L
E
E
I
K
P
Y
L
-----
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
----
P
K
A
I
H
V
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
-
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
----
E
E
D
E
R
----
K
I
R
R
I
G
V
R
F
S
K
F
I
-----------------
30
PsiBlast_CBE
68.55
40%
-25
- C1 -
-
4R8U
1
?
B:
[1-336]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
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F
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A
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E
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R
D
N
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A
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R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
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M
A
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A
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N
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D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
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E
I
R
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E
L
Q
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L
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A
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D
M
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K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
--------------------
22
PsiBlast_CBE
68.42
40%
-20
- C1 -
-
4Q43
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
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D
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F
F
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A
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M
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N
P
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I
P
I
A
I
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---
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S
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E
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----
R
G
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A
N
Y
P
A
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D
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Y
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E
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I
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R
Y
T
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E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
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A
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V
K
F
L
A
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I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
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W
E
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Q
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I
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E
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D
V
N
S
E
R
L
R
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S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
1
PsiBlast_PDB
68.32
40%
-20
- C1 -
-
4IR1
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
21
PsiBlast_CBE
67.85
40%
-18
- C1 -
-
5C5J
5
?
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
3
PsiBlast_PDB
67.78
40%
-18
- C1 -
-
4Q43
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
4
PsiBlast_PDB
67.61
40%
-17
- C1 -
-
5C5J
2
?
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
2
PsiBlast_PDB
67.53
40%
-17
- C1 -
-
4IR9
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
24
PsiBlast_CBE
67.02
40%
-20
- C1 -
-
4IR1
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
27
PsiBlast_CBE
66.30
41%
16
- C1 -
-
4IRK
3
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
23
PsiBlast_CBE
66.25
40%
-18
- C1 -
-
4IR9
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
---
G
S
R
E
R
----
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
8
PsiBlast_PDB
65.98
41%
9
- C1 -
-
4Q44
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
28
PsiBlast_CBE
65.43
41%
17
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
5
PsiBlast_PDB
64.89
41%
18
- C1 -
-
4IRC
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
SRER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
26
PsiBlast_CBE
64.64
41%
14
- C1 -
-
4Q44
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
SRER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
9
PsiBlast_PDB
64.26
41%
16
- C1 -
-
4Q45
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
SRER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
6
PsiBlast_PDB
64.16
41%
16
- C1 -
-
4IRD
3
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
SRER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
25
PsiBlast_CBE
63.97
41%
14
- C1 -
-
4Q45
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
7
PsiBlast_PDB
63.91
41%
16
- C1 -
-
4IRK
5
DPO4_ECOLI
B:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
SRER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HHW
S
E
C
E
A
I
I
E
R
L
YPELE
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
10
PsiBlast_PDB
61.90
40%
14
- C1 -
-
4R8U
1
DPO4_ECOLI
A:
[1-340]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
-----------------
59
Fugue
60.13
30%
24
- C1 -
-
2OH2
3
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
-------
G
S
----
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
--
E
R
-
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
T-
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
-
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
----
N
K
A
E
E
Q
Y
S
L
C
-----
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
--
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
A
D
F
P
-
H
P
L
----
R
L
R
L
M
G
V
R
I
S
S
F
P
-----------------
29
PsiBlast_CBE
59.91
41%
20
- C1 -
-
4IRC
5
DPO4_ECOLI
A:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
-------
G
G
S
RER
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
-
V
--
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
-
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
HH
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
K
P
D
L
L
--
I
A
--
R
Q
G
----
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
P
R
--
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
----
G
--
G
R
----
G
V
R
L
V
G
L
H
V
T
L
L
D
P
----------------
60
Fugue
57.16
30%
29
- C1 -
-
2W7O
3
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
-------
G
S
----
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
--
E
R
-
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
-
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
----
N
K
A
E
E
Q
Y
S
L
C
-----
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
R
--
L
K
G
R
T
V
T
I
K
L
K
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
E
I
----
D
-
A
D
F
PHPL
R
L
R
L
M
G
V
R
I
S
S
F
P
N
E
---------------
13
PsiBlast_PDB
55.68
36%
-24
- C1 -
-
4F4Y
3
DPO4_SULAC (first)
A:
[3-278]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
C
V
Y
S
G
R
T
K
T
----
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
-
N
K
V
EG
N
F
-
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
I
T
G
K
-
A
K
A
L
Y
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
Y
L
T
L
--
P
Y
---
N
T
R
D
-
V
K
V
I
L
-----
P
Y
L
K
K
A
I
N
E
A
Y
N
K
V
N
-------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.88
36%
-23
- C1 -
-
4F4Y
3
DPO4_SULAC (first)
B:
[3-278]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
C
V
Y
S
G
R
T
K
T
----
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
-
N
K
V
EG
N
F
-
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
I
T
G
K
-
A
K
A
L
Y
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
-
T
R
V
R
K
S
I
G
R
Y
L
T
L
--
P
Y
---
N
T
R
D
-
V
K
V
I
L
-----
P
Y
L
K
K
A
I
N
E
A
Y
N
K
V
N
-------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.46
40%
-67
- C1 -
-
3BQ1
3
DPO4_SULAC
A:
[3-206]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
P
Q
Y
K
G
K
P
L
V
V
C
V
Y
S
G
R
T
K
T
----
S
G
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
M
P
I
I
K
A
M
Q
I
A
P
S
A
I
Y
V
P
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
-
N
K
V
EG
N
F
-
E
--------------------
N
G
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
N
G
L
G
V
I
R
P
--
T
E
V
Q
D
F
L
N
E
L
D
I
D
E
I
P
G
I
G
S
V
L
A
R
R
L
N
E
L
G
I
Q
K
L
R
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------