@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZ69: (2018-01-12 )
MRQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVSAGIYSYLPLANRVLEKLKRIMREEFEKIGAVEMLMPAILPAELWEESGRYETYGPNLYRFKDRNDRKMILGPTHEETFTDLMRNEINSYKKLPLNLYQIQPKYRDEKRPRFGLLRGREFIMKDAYSFHATEESLDETYKDYEKAYTEVFKRCGLEFRSIIGDGGAMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSYYVSKKSHETQLELEKVATPNVKSIDEVADFFSVEPQKIIKSVLFIADEQPVLVLVRGDHEVNDVKLKNFLSADFLEEATEEEAQKYLGAEFGSVGPVGVSDDVKVYADRYVQDLANAITGANETGFHYKNVNPERDFTVLSYEDLRFVQEGDPSPDNNGVLAFTRGIEIGHIFKIGTRYSESMGATVLDENGREKFVIMGCYGIGVSRLLSAIVEQHSDEQGINWPKGIAPFDLHIVQMNLKDEYQTNLTNELEEAMTKAGYEVLVDDRNERAGVKFADSDLIGCPIRITVGKKAVDGIVEVKIKKTGEMVEVRKEELVNTLPILLNQGE
Atome Classification :
(20 SA)
.........10........20........30...-.....40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.....-..190.-......200.......210.......220.....-..230.......240.......250.......260.......270.......280...--....290--.......300......-.310.-......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.--......490.......500.......-510..--.......520.......530...-....540.......550.......560.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRQSKML
I
P
T
L
R
EVP
N
D
A
E
V
L
S
H
Q
I
L
L
RAG
Y
I
R
Q
-
V
S
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
R
I
M
R
E
E
F
E
KI
G
A
V
E
M
L
M
P
A
IL
P
A
E
L
W
E
ESGRYETYGPN
L
Y
R
FKDRND
R
K
M
I
LGPT
H
E
E
T
F
T
D
L
M
R
N
E
I
N
S
YKKLP
L
N
L
Y
Q
IQPKYRDEKRPRFGLLR
G
R
E
F
I
M
K
D
A
YSFHA
T
E
E
S
L
D
E
T
Y
K
D
Y
E
K
A
Y
T
E
V
F
K
R-C
G
L
E
F
R
-
S
I
IGDGGAMGGKD
S
K
E
F
M
A
I
S
EIGED
T
I
C
Y
STES-DYAAN
L
E
M
A
T
S
Y
Y
V
SKKSHE
T
Q
L
E
L
E
KVATPNV
K
S
I
D
E
V
A
D
F
FSV
E
P
Q
K
I
I
K
S
V
L
F
IA--DEQ
P
V
L
V
--
L
V
RGDHEV
N
D
V
K
L
K
N
F
-
L
S
A
D
F
-
L
E
E
A
T
E
E
E
A
Q
K
Y
L
G
AEFGSVGPVGVSD
D
V
K
V
Y
A
D
R
Y
V
Q
D
L
A
N
A
ITGANETGFHYKNVNPER
D
F
T
V
L
S
Y
E
D
L
R
F
V
QEGDPSPDNN
G
V
L
A
F
TRGIEI
G
H
I
F
K
IGTRYSESMG
A
T
V
LDENGR
E
K
F
V
I
M
G
C
YGI
G
V
S
R
L
L
S
A
I
V
E
QHSDEQGINWPKGIAP
F
D
L
H
I
V
Q
MNLK
D
E
--
Y
QT
N
L
T
N
E
L
E
E
A
M
T
KAG
Y
E
V
L
V
DDRN-E--RA--G
V
K
FADSDLIGC
P
I
R
I
T
VGKKAV-D
G
I
V
E
V
K
I
KKTG
E
M
V
E
V
R
K
E
E
L
V
N
T
L
P
ILLNQGE
30
Fugue
97.87
83%
-84
- C1 -
-
2J3L
1
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
----
1
PsiBlast_PDB
97.87
83%
-84
- C1 -
-
2J3L
1
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
----
41
HHSearch
96.07
84%
-80
* C1 *
-
2J3L
1
SYP_ENTFA
B:
[1-566]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
N
---
22
PsiBlast_CBE
95.82
83%
-80
- C1 -
-
2J3L
1
SYP_ENTFA
B:
[1-566]
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
N
---
21
PsiBlast_CBE
95.20
83%
-75
- C1 -
-
2J3M
2
SYP_ENTFA
B:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
----
40
HHSearch
93.18
84%
-79
- C1 -
-
2J3M
2
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
----
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
----
2
PsiBlast_PDB
92.93
83%
-79
- C1 -
-
2J3M
2
SYP_ENTFA
A:
[1-565]
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
I
R
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
D
R
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
I
M
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
-
C
G
L
E
F
R
-
A
I
I
G
D
G
----
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
-
D
Y
A
A
N
L
E
M
A
T
S
L
Y
T
P
K
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
--
D
E
E
P
V
M
V
--
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
-
L
G
A
D
F
-
L
D
E
A
T
E
E
D
A
R
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
-
E
--
R
A
--
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
T
L
S
I
L
M
----
42
HHSearch
72.37
48%
-20
- C1 -
-
5UCM
-
SYP_PSEAE
B:
[9-578]
M
R
T
S
Q
Y
L
L
S
-----
P
A
D
A
V
V
I
S
H
Q
L
L
L
R
A
G
M
I
R
R
-
L
A
S
G
L
Y
T
W
L
P
M
G
L
R
V
L
R
K
V
E
T
I
V
R
E
E
M
N
A
A
G
A
L
E
V
L
M
P
A
V
Q
P
A
E
L
W
Q
E
S
G
R
W
E
Q
Y
G
P
E
L
L
R
L
K
D
R
H
E
R
E
F
C
V
G
P
T
H
E
E
V
I
T
D
L
A
R
N
E
L
N
S
Y
K
Q
L
P
I
N
F
Y
Q
I
Q
T
K
F
R
D
E
I
R
P
R
F
G
L
M
R
G
R
E
F
I
M
K
D
A
Y
S
F
H
L
S
Q
D
S
L
Q
Q
T
Y
D
G
M
Y
Q
A
Y
S
K
I
F
S
R
-
L
G
L
D
F
R
-
P
V
Q
A
D
N
G
S
I
G
G
S
G
S
H
E
F
H
V
L
A
N
S
G
E
D
D
I
V
F
S
D
S
S
-
D
Y
A
A
N
I
E
K
A
E
A
V
P
R
E
S
A
R
G
S
A
T
E
D
M
R
L
V
D
T
P
N
T
K
T
I
A
A
L
V
D
G
F
Q
L
P
I
E
K
T
I
K
T
L
V
V
H
G
AE
E
G
T
L
V
A
L
--
I
V
R
G
D
H
E
L
N
E
I
K
A
A
N
Q
-
P
L
V
A
S
P
L
V
F
A
S
E
A
E
I
R
A
A
I
G
A
G
P
G
S
L
G
P
V
N
L
P
--
I
A
C
I
V
D
R
S
V
A
L
M
S
D
F
A
A
G
A
N
I
E
D
K
H
Y
F
G
V
N
W
E
R
D
L
P
L
P
E
V
A
D
L
R
N
V
V
E
G
D
P
S
P
D
G
K
G
T
L
V
I
K
R
G
I
E
V
G
H
I
F
Q
L
G
T
K
Y
S
E
A
M
K
L
S
V
L
S
E
Q
G
K
P
V
N
L
I
M
G
C
Y
G
I
G
V
S
R
V
V
A
A
A
I
E
Q
N
H
D
E
R
G
I
L
W
P
S
A
L
A
P
F
Q
I
A
L
V
P
L
K
Y
E
T
E
--
S
V
K
Q
A
T
D
K
L
Y
A
E
L
T
A
A
G
F
E
V
L
L
D
D
R
D
-
K
KT
S
P
--
G
V
K
F
A
D
M
E
L
I
G
I
P
H
R
I
V
I
S
D
R
G
L
S
E
G
V
L
E
Y
K
G
R
R
D
S
E
S
Q
N
L
P
I
G
E
L
M
S
F
I
T
E
K
L
S
---
3
PsiBlast_PDB
69.47
48%
-25
- C1 -
-
5UCM
-
SYP_PSEAE
A:
[10-560]
-
R
T
S
Q
Y
L
L
S
-----
P
A
D
A
V
V
I
S
H
Q
L
L
L
R
A
G
M
I
R
R
-
L
A
S
G
L
Y
T
W
L
P
M
G
L
R
V
L
R
K
V
E
T
I
V
R
E
E
M
N
A
A
G
A
L
E
V
L
M
P
A
V
Q
P
A
E
L
W
Q
E
S
G
R
W
E
Q
Y
G
P
E
L
L
R
L
K
D
R
H
E
R
E
F
C
V
G
P
T
H
E
E
V
I
T
D
L
A
R
N
E
L
N
S
Y
K
Q
L
P
I
N
F
Y
Q
I
Q
T
K
F
R
D
E
I
R
P
R
F
G
L
M
R
G
R
E
F
I
M
K
D
A
Y
S
F
H
L
S
Q
D
S
L
Q
Q
T
Y
D
G
M
Y
Q
A
Y
S
K
I
F
S
R
-
L
G
L
D
F
R
-
P
V
Q
A
D
N
G
S
I
G
G
S
G
S
H
E
F
H
V
L
A
N
S
G
E
D
D
I
V
F
S
D
S
S
-
D
Y
A
A
N
I
E
K
A
E
A
V
P
R
E
S
A
R
G
S
A
T
E
D
M
R
L
V
D
T
P
N
T
K
T
I
A
A
L
V
D
G
F
Q
L
P
I
E
K
T
I
K
T
L
V
V
H
G
--
A
E
E
G
T
L
V
A
L
I
V
R
G
D
H
E
L
N
E
I
K
A
A
N
Q
P
L
V
A
S
P
-
L
V
F
A
S
E
A
E
I
R
A
A
I
G
A
G
P
G
S
L
G
P
V
N
L
P
--
I
A
C
I
V
D
R
S
V
A
L
M
S
D
F
A
A
G
A
N
I
E
D
K
H
Y
F
G
V
N
W
E
R
D
L
P
L
P
E
V
A
D
L
R
N
V
V
E
G
D
P
S
P
D
G
K
G
T
L
V
I
K
R
G
I
E
V
G
H
I
F
Q
L
G
T
K
Y
S
E
A
M
K
L
S
V
L
S
E
Q
G
K
P
V
N
L
I
M
G
C
Y
G
I
G
V
S
R
V
V
A
A
A
I
E
Q
N
H
D
E
R
G
I
L
W
P
S
A
L
A
P
F
Q
I
A
L
V
P
L
K
Y
E
T
E
--
S
V
K
Q
A
T
D
K
L
Y
A
E
L
T
A
A
G
F
E
V
L
L
D
D
R
D
-
K
--
K
T
S
P
G
V
K
F
A
D
M
E
L
I
G
I
P
H
R
I
V
I
S
D
R
G
L
S
E
G
V
L
E
Y
K
G
R
R
D
S
E
---------------------
44
HHSearch
62.27
42%
-22
- C1 -
-
2I4L
-
SYP_RHOPA
C:
[1-437]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
P
M
R
A
E
T
-
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
D
V
L
N
L
P
V
P
-
D
------------------------------
E
N
V
D
Y
D
-----------------------------
G
D
L
T
P
I
I
K
Q
W
T
S
V
-
Y
A
----------------------------------
A
T
-----------------
E
D
V
H
E
P
------------------
A
R
Y
E
S
E
V
P
E
A
--
N
R
L
N
T
R
G
I
E
V
G
Q
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
D
G
T
D
A
P
I
H
G
G
S
Y
G
V
G
V
S
R
L
L
G
A
I
I
E
A
C
H
D
D
N
G
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
L
K
Q
G
D
A
--
A
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
K
G
V
D
V
L
Y
D
D
T
D
-
Q
--
R
A
--
G
A
K
F
A
T
A
D
L
I
G
I
P
W
Q
I
H
V
G
P
R
G
L
A
E
G
K
V
E
L
K
R
R
S
D
G
A
R
E
N
L
A
L
A
D
V
V
A
R
L
--------
43
HHSearch
58.40
42%
-25
- C1 -
-
2I4N
1
SYP_RHOPA
C:
[21-457]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
P
M
R
A
E
T
-
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
D
V
L
N
L
P
V
P
-
D
------------------------------
E
N
V
D
Y
D
-----------------------------
G
D
L
T
P
I
I
K
Q
W
T
S
V
-
Y
A
----------------------------------
A
T
-----------------
E
D
V
H
E
P
------------------
A
R
Y
E
S
E
V
P
E
A
--
N
R
L
N
T
R
G
I
E
V
G
Q
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
D
G
T
D
A
P
I
H
G
G
S
Y
G
V
G
V
S
R
L
L
G
A
I
I
E
A
C
H
D
D
N
G
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
L
K
Q
G
D
A
--
A
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
K
G
V
D
V
L
Y
D
D
T
D
-
Q
--
R
A
--
G
A
K
F
A
T
A
D
L
I
G
I
P
W
Q
I
H
V
G
P
R
G
L
A
E
G
K
V
E
L
K
R
R
S
D
G
A
R
E
N
L
A
L
A
D
V
V
A
R
L
--------
7
PsiBlast_PDB
48.55
49%
-85
- C1 -
-
2I4O
1
SYP_RHOPA
A:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
48.54
49%
-80
- C1 -
-
2I4M
1
SYP_RHOPA
C:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
48.20
21%
1
- C1 -
-
4WI1
8
SYP_PLAF7
B:
[24-409]
-------------------
D
W
Y
T
Q
V
I
V
K
S
E
L
I
E
Y
Y
D
I
S
G
C
Y
I
L
R
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
E
I
K
K
L
N
V
E
N
S
Y
F
P
--------------------------------------
E
T
I
M
Y
S
V
F
P
K
W
I
R
S
Y
R
D
L
P
L
K
L
N
Q
W
N
T
V
V
R
W
E
F
K
Q
P
T
-----
R
E
F
L
W
Q
E
G
H
T
A
H
K
N
E
E
E
A
V
K
L
V
F
D
I
L
D
L
Y
R
R
W
Y
E
E
Y
L
A
V
P
I
I
-
K
G
I
K
S
E
G
----------------------------------
E
K
F
G
G
---------------------------------
A
-------------------------------------------------------------------------------------------------
N
F
T
-
S
T
------
A
E
A
--
F
I
S
-----------------
E
N
G
R
A
I
Q
A
A
T
S
H
Y
L
G
T
N
F
A
K
M
F
K
I
E
F
E
D
E
N
E
V
K
Q
Y
V
H
Q
T
S
W
G
C
-
T
T
R
S
I
G
I
M
I
M
T
H
G
D
D
K
G
L
V
L
P
P
N
V
S
K
Y
K
V
V
I
V
P
I
F
----E
N
A
I
H
S
Y
C
K
D
I
E
K
I
L
K
N
A
Q
I
N
C
V
Y
D
D
R
A
S
Y
--
S
P
--
G
Y
K
F
N
H
W
E
L
R
G
I
P
I
R
I
E
V
G
P
K
D
L
Q
N
N
S
C
V
I
V
R
R
D
N
N
E
K
C
N
V
K
K
E
S
V
L
L
E
T
Q
Q
M
L
V
D
I
-
25
PsiBlast_CBE
47.97
49%
-79
- C1 -
-
2I4O
2
SYP_RHOPA
B:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
47.95
49%
-82
- C1 -
-
2I4O
2
SYP_RHOPA
C:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
47.71
49%
-79
- C1 -
-
2I4M
1
SYP_RHOPA
B:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.53
49%
-88
- C1 -
-
2I4M
-
SYP_RHOPA
A:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.48
49%
-82
- C1 -
-
2I4N
1
SYP_RHOPA
A:
[21-241]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.19
49%
-86
- C1 -
-
2I4L
-
SYP_RHOPA
A:
[1-221]
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
L
R
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
D
R
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
L
M
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
-
M
G
L
K
A
I
-
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------