@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S8GBW3_TOXGM: (2017-06-15 )
MGHPPPWTASPLFFLLLFWHAPPSLVSSCLHAGHALHVHPAHNPSLPPLSLPSDRPGAAGDGQTGASLVHNARAALPLCASRVFAGGALQPSTAVPPRTQPLHRCARRYAPSGRLLLKPRLGLKALPIHEVAEGRAEQEDRARPPDPSVSGRTLTCVTLRTKETCNDADCGGLACRTGNATIAGRGARASDGRQPPTKQEGVFPVATSFRFSSRSLRSSTPLSRYFLSSSPSENKFEFHHFLSYTVTAELPTSAFTFVDAPQSLTSCADVWSHPCRAFVFFPLQRSRTSVGFSPSSHSIRPSPRRWFSSVNLCALRASFGSIASSCSSPVGPDHSSLTAVAITRAVRCFPSHSAPFPPSSSCDLLSASSPSHASLPACSASASSSSPPSRARPTVCLYVPRTHSPRPPRSVGSAASPSSGGPRVSQSEGTPSGPVDSPLSPTSRGSCSYSTPSVSCPGGLLLSLPSVSPVSLSTSLRHFLVSYTSPFPARSLPLIFVDAGLSLASDASLHAARPVGLSQEHRETCASALGSLIDTAVASNAVAQTSCECRPRGLPIVYSPRLVPPSFPRNHCLQPQKLGRLFSFLTHPSGASNLRTPESGVTKTWEAREAEIAKATSGVEGSHEFRWDYVTVHSDLRPKRLNSDHPVTKAGIGVGENRGREKNGEDGRPSEAGCEKSTSPSHALSPSASVPHGPVDATRQNGCGRDDPPRCTHPAGVQVTAGNELNRNPLLAGSHDQHMDSTRATLGTSVSSCFSLFSPIHDADVTRAWLQVVHAPEYVCAASAAVLSEEEERKIGFPVTKGYADKSLAEVSSTVLGTWLAFHFGLACVVGGGTHHAKTDSGGKFCVFNDVAVAAALALKQGIAERILILDLDVHQGDGTAEIFSNEPRVKTVSIHCEDNFPFPKAQSDVDIGLPAGTGDEVYLRQLNEVG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.........730.......740.......750.......760-........770.......-780.....-.--.--------790------------------------.-----------------------.-----...-----------....800.......810.......820.----...-...830..--.....840.......850.......860-.-.......870.......880.......890....-..---.---900..-..------------.----------.------------...910...-..-..920.......930
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGHPPPWT
A
S
P
L
F
F
L
L
L
F
WHA
P
P
S
L
V
S
S
C
L
HAG
H
A
L
H
V
HPAHNPSLPPLSLPSDRPGAAGDGQ
T
G
A
S
L
V
H
NARA
A
L
P
L
C
A
S
R
V
FAGGALQPSTAVPPR
T
Q
P
L
H
R
C
A
R
RYAPSG
R
L
L
L
KPRLG
L
K
AL
P
I
H
E
V
AEGRAEQEDRARPPDPSVSG
R
T
L
T
C
V
T
LRTKETCNDADCG
G
L
A
CRTGN
A
T
I
AGRGARASDGRQPPTKQEG
V
F
P
V
A
T
S
F
R
FSSRSLRSSTP
L
S
R
Y
FLSSSPSENK
F
E
F
H
H
F
L
S
Y
T
V
T
AELPTS
A
F
T
F
VDA
P
Q
S
L
T
S
C
A
D
V
W
SHP
C
R
A
F
V
F
F
PLQRSRTSVGFSPSSHSIRP
S
P
R
R
W
F
S
SV
N
L
C
A
L
R
A
S
F
G
S
I
A
S
S
CSSPVGPDHS
S
L
T
A
V
A
I
T
R
A
V
R
CFPSHSAPFPPSSSCDLLSASSPSHASLPACSASASSSSPPSRAR
P
T
V
C
L
YVPRTHSPRPPRSVGSAASPSSGGPRVSQSEGTPSGPVDSPLSPTSRGSCSYSTPSVSCPG
G
L
L
L
SLPSVSP
V
S
L
S
T
S
L
R
H
F
L
V
S
YTSPFPARSL
P
L
I
F
VDAGLSLASDASLHAARPVGL
S
Q
E
H
R
E
T
C
A
S
A
L
G
S
L
I
D
T
A
V
ASNAVAQTSCECRPRG
L
P
I
V
YSPRLVPPSFPRNHCL
Q
P
Q
K
L
G
R
L
F
S
F
L
THPSGASNLRTPESGVTKTW
E
A
R
E
A
E
I
A
K
ATSGVEGS
H
E
F
R
W
D
Y
V
T
VHSDLRPKRLNSDHPVTKAGIGVGENRGREKNGEDGRPSEAGCEKSTSPSHALSPSASVPHGPVDATRQNGCGRDDPPRCTHPA
G
V
Q
V
T--AGNELNRNPLLAGS
H
D
Q
H
M
D
S
T
R
A
T
LG
T
S
V
S
S
C
F
S
L
FSPIH--
D
A
D
V
T
R
A
W
L
Q
V
VHAP
E
Y
V
-
C
A
A
S
A
A
V
L-S--E--------E--------------------------E-----------------------E-----RKI-----------GFPVTKGYAD
K
S
L
A
E
V
S
S
T
V
L
G
T
W
L
A
F
H
----
F
G
L
-
A
C
V
VGGGT--HHAKTDSGG
K
F
C
V
F
N
D
V
A
V
A
A
A
L
A
L
K
Q
--
G
-
I
A
E
R
I
L
I
L
D
L
D
VHQGDG
T
A
E
I
FSNEP
R
V
K
T
V
S
I
H
-CE---D---N--FP-FP------------K----------A------------QSD
V
D
IGLP-AG-TG
D
E
V
Y
L
R
Q
L
N
EVG
236
HHSearch
71.71
25%
-45
- C6 -
-
4BZ7
10
?
A:
[17-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
K
F
G
D
R
Y
A
L
V
M
D
L
I
N
-------
A
Y
K
L
I
P
E
L
S
R
V
P
P
L
Q
WD
S
P
S
R
M
Y
E
A
V
T
A
F
H
S
T
E
Y
V
-
D
A
L
K
K
L
Q
M
-
L
--
H
--------
C
E
EK-----------------------
E
LT
A
D
D
E
L
L
M
D
S
------------
F
S----
L
N
Y
-----------
D
C
P
G
F
P
S
V
F
D
Y
S
L
A
A
V
Q
G
S
L
A
A
A
S
A
L
I
C
R---
H
C
E
V
V
I
N
W
G
G
G
W
--
H
H
A
K
R
S
E
A
S
G
F
C
Y
L
N
D
I
V
L
A
I
H
R
L
V
S
S
TP---
Q
T
R
V
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
E
A
F
W
Y
S
P
R
V
V
T
F
S
V
H
-
H
A
---
S
PG-
F
--
F
P
-
G
T
------------
G
----------
T
WNIFLNGAGRGR
F
S
A
F
N
L
P
L
E
-
E
G
-
I
N
D
L
D
W
S
N
A
I
G
P
I
L
228
HHSearch
70.72
24%
-74
- C6 -
-
4A69
7
HDAC3_HUMAN
A:
[20-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
H
P
M
K
P
H
R
L
A
L
T
H
S
L
V
L
-------
H
Y
G
L
Y
K
K
M
I
V
F
K
P
Y
Q
-----
A
S
Q
H
D
M
C
R
F
H
S
E
D
Y
I
-
D
F
L
Q
R
V
S
P
-
T
--
N
--------
M
Q-------------------------
G
F
T
K
S
L
N
A
F
---------------
N
-----
V
G
D
-----------
D
C
P
V
F
P
G
L
F
E
F
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
N
N
KI--
C
D
I
-
A
I
N
W
A
G
G
L
--
H
H
A
K
K
F
E
A
S
G
F
C
Y
V
N
D
I
V
I
G
I
L
E
L
L
K
Y
-----
H
P
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
Q
E
A
F
Y
L
T
D
R
V
M
T
V
S
F
H
-
K
Y
---
G
NY-
F
--
F
P
-
G
T
------------
G
DMYEVGAESG
R
------------
Y
Y
C
L
N
V
P
L
R
-
D
G
-
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
I
221
HHSearch
70.52
26%
-38
- C6 -
-
5JI5
6
?
A:
[27-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
H
P
E
C
P
A
R
L
Q
A
I
E
D
Q
L
I
A
-------
S
R
I
G
E
L
I
E
R
E
S
A
P
L
-----
A
D
E
A
A
L
L
R
V
H
T
K
A
H
V
-
D
Y
L
R
A
R
S
P
-
Q
--
S
--------
G
Y-------------------------
A
-----------------------
E
-----
I
D
P
-----------
D
T
S
M
N
P
H
T
W
T
A
A
L
R
A
A
G
A
A
V
A
A
T
D
A
V
I
E
GRYD
N
A
F
--
C
S
V
R
P
P
G
--
H
H
A
E
P
A
R
A
M
G
F
C
F
F
N
N
V
A
I
A
A
R
H
A
L
E
V
--
H
-
K
L
E
R
V
A
I
I
D
F
D
V
H
H
G
N
G
T
E
A
A
F
S
N
D
A
R
V
L
M
C
S
I
F
-
Q
H
---
P
---
F
--
Y
P
-
F
T
------------
G
ADNQ------
A
------------
P
N
M
C
N
V
P
I
A
-
A
R
-
S
K
G
M
V
V
R
E
A
I
D
M
I
W
234
HHSearch
70.28
27%
-42
- C6 -
-
5EDU
4
HDAC6_HUMAN
B:
[408-635]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
H
P
E
V
P
Q
R
I
L
R
I
M
C
R
L
E
E
-------
L
G
L
A
G
R
C
L
T
L
T
P
R
P
-----
A
T
E
A
E
L
L
T
C
H
S
A
E
Y
V
-
G
H
L
R
A
T
E
K
M
K
--
T
--------
R
--------------------------
E
L
H
R
E
S
------------------
S
-----
N
F
D
-----------
S
I
Y
I
C
P
S
T
F
A
C
A
Q
L
A
T
G
A
A
C
R
L
V
E
A
V
L
S
GEVL
N
G
A
--
A
V
V
R
P
P
G
--
H
H
A
E
Q
D
A
A
C
G
F
C
F
F
N
S
V
A
V
A
A
R
H
A
Q
T
I
--
S
G
H
A
L
R
I
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
-
R
Y
---
D
HGT
F
--
F
P
-
M
G
DEGASSQIGRAA
G
----------
T
------------
G
F
T
V
N
V
A
W
N
G
P
R
-
M
G
D
A
D
Y
L
A
A
W
H
R
L
V
4
PsiBlast_PDB
69.06
32%
-16
- C5 -
-
5G0G
7
?
A:
[75-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
22
PsiBlast_CBE
68.91
32%
-16
- C5 -
-
5EEF
4
?
B:
[60-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
225
HHSearch
68.76
24%
-69
- C6 -
-
4LY1
6
HDAC2_HUMAN
A:
[20-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
-------
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
K
-----
A
T
A
E
E
M
T
K
Y
H
S
D
E
Y
I
-
K
F
L
R
S
I
R
P
-
D
--
N
--------
M
SEY
S
K
---------------------
Q
-----------------------
M
Q
R
F
N-
V
G
E
-----------
D
C
P
V
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
G
A
V
K
L
N
R
QQ--
T
D
M
-
A
V
N
W
A
G
G
L
--
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
-----
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
-
K
Y
---
G
E--
Y
--
F
P
-
G
T
------------
G
DLRDIGAGKG
K
------------
Y
Y
A
V
N
F
P
M
R
-
D
G
-
I
D
D
E
S
Y
G
Q
I
F
K
P
I
I
222
HHSearch
68.76
21%
-30
- C6 -
-
5EEI
11
?
A:
[27-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
-------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
-----
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
-
M
--
K
P
-------
R
--------------------------
D
L
N
R
L
G
------------------
D
-----
E
Y
N
-----------
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
GQVR
N
A
V
--
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
--
T
R
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
-
R
Y
---
E
DGA
F
--
F
P
-
N
S
EDANYDKVGLGK
G
----------
R
------------
G
Y
N
V
N
I
P
W
N
-
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
21
PsiBlast_CBE
68.49
32%
-12
- C5 -
-
5G0I
5
?
B:
[91-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
1
PsiBlast_PDB
67.65
32%
-15
- C5 -
-
5G0I
5
?
A:
[91-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
3
PsiBlast_PDB
67.52
32%
-12
- C5 -
-
5EEF
5
?
A:
[60-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
224
HHSearch
67.46
23%
-45
- C6 -
-
5G0G
8
?
A:
[42-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
H
P
E
C
P
A
R
V
S
T
V
M
E
M
L
E
T
-------
E
G
L
L
G
R
C
V
Q
V
E
A
R
A
-----
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
-
E
L
M
K
S
T
Q
N
-
M
T-
E
--------
E
--------------------------
E
-----------------------
L
K
T
L
A
E
K
Y
D
-----------
S
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
SQLR
N
G
F
--
S
I
N
R
P
P
G
--
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
-
R
Y
EDG
S
---
F
--
W
P
-
H
L
KESDSSSVGSGA
G
----------
Q
------------
G
Y
N
I
N
L
P
W
N
K
V
G
-
M
E
S
G
D
Y
I
T
A
F
Q
Q
L
L
2
PsiBlast_PDB
67.44
32%
-15
- C5 -
-
5G0J
4
?
A:
[76-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
D
E
L
L
L
V
H
T
K
E
Y
V
E
L
M
K
S
T
Q
N
M
-
T
--
E
--------
E
--------------------------
E
-----------------------
L
-----
K
T
L
A
E
K
Y
DS
V
Y
L
H
P
G
F
F
S
S
A
C
L
S
V
G
S
V
L
Q
L
V
D
K
V
M
T
S
Q
L
R
N
G
----
F
S
I
-
N
R
P
P
G
-----
H
H
A
Q
A
D
K
M
N
G
F
C
M
F
N
N
L
A
I
A
A
R
Y
A
Q
K
R
--
H
-
R
V
Q
R
V
L
I
V
D
W
D
V
H
H
G
Q
G
I
Q
Y
I
F
E
E
D
P
S
V
L
Y
F
S
V
H
R
Y
E
---
D
---
G
SF
W
P
-
H
L
------------
K
----------
E
------------
S
D
S
S
S
V
G
S
G
-
A
G
-
Q
G
Y
N
I
N
L
-
P
W
N
K
V
G
231
HHSearch
67.08
21%
-27
* C6 *
-
5G0H
12
?
A:
[423-649]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
H
H
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
E
-------
L
R
L
L
S
R
C
H
R
I
P
A
R
L
-----
A
T
E
E
E
L
A
L
C
H
S
S
K
H
I
-
S
I
I
K
S
S
E
H
M
K
--
P
--------
R
--------------------------
D
L
N
R
L
G
------------------
D
-----
E
Y
N
-----------
S
I
F
I
S
N
E
S
Y
T
C
A
L
L
A
A
G
S
C
F
N
S
A
Q
A
I
L
T
GQVR
N
A
V
--
A
I
V
R
P
P
G
--
H
H
A
E
K
D
T
A
C
G
F
C
F
F
N
T
A
A
L
T
A
R
Y
A
Q
S
I
T-
R
-
E
S
L
R
V
L
I
V
D
W
D
V
H
H
G
N
G
T
Q
H
I
F
E
E
D
D
S
V
L
Y
I
S
L
H
-
R
Y
---
E
DGA
F
--
F
P
-
N
S
EDANYDKVGLGK
G
----------
R
------------
G
Y
N
V
N
I
P
W
N
-
G
G
K
M
G
D
P
E
Y
M
A
A
F
H
H
L
V
237
HHSearch
65.96
24%
-38
- C6 -
-
1C3P
-
?
A:
[19-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
H
P
L
K
I
P
R
V
S
L
L
L
R
F
K
D
-------
A
M
N
L
I
D
E
K
E
L
I
K
S
R
P
-----
A
T
K
E
E
L
L
L
F
H
T
E
D
Y
I
-
N
T
L
M
E
A
E
R
-
C
--
Q
CVPK----
G
--------------------------
A
REKYN------------------
I
-----
G
G
Y
-----------
E
N
P
V
S
Y
A
M
F
T
G
S
S
L
A
T
G
S
T
V
Q
A
I
E
E
F
L
K
----
G
N
V
---
A
F
N
P
A
G
GM
H
H
A
F
K
S
R
A
N
G
F
C
Y
I
N
N
P
A
V
G
I
E
Y
L
R
K
---
K
-
G
F
K
R
I
L
Y
I
D
L
D
A
H
H
C
D
G
V
Q
E
A
F
Y
D
T
D
Q
V
F
V
L
S
L
H
-
Q
S
---
P
EY-
A
--
F
P
-
F
E
KGFLEEIGEGK-
G
----------
K
------------
G
Y
N
L
N
I
P
L
P
-
K
G
-
L
N
D
N
E
F
L
F
A
L
E
K
S
L
229
HHSearch
65.29
20%
7
- C6 -
-
3MEN
11
APHA_BURP1
A:
[21-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
T
Y
F
H
P
D
Q
S
L
H
H
P
R
T
Y
F
S
R
G
R
M
R
M
P
Q
E
V
P
E
R
A
A
R
L
V
A
A
A
F
A
-------
M
G
----
F
P
V
R
E
P
D
D
-----
F
G
I
A
P
I
A
A
V
H
D
T
H
Y
L
-
R
F
L
E
T
V
H
R
-
E
--
W
K
A
MPEDWG
D
--------------------------
E
A
M
S
NIFVREPNALRG
V
L
A
Q
A
A
R
H
L
-----
A
D
G
-----------
S
C
P
V
G
E
H
T
W
R
A
A
Y
W
S
A
Q
S
A
L
A
A
A
A
A
V
R
D
GAP-
A
A
Y
--
A
L
C
R
P
P
G
--
H
H
A
R
V
D
A
A
G
G
F
C
Y
L
N
N
A
A
I
A
A
Q
A
L
R
A
R
-----
H
A
R
V
A
V
L
D
T
D
M
H
H
G
Q
G
I
Q
E
I
F
Y
A
R
R
D
V
L
Y
V
S
I
H
-
G
D
---
P
TN-
F
--
Y
P
-
A
V
AGFDDERGAGE-
G
----------
L
------------
G
Y
N
V
N
L
P
M
P
-
H
G
-
S
S
E
A
A
F
F
E
R
V
D
D
A
L
233
HHSearch
65.05
24%
-63
- C6 -
-
4BKX
7
HDAC1_HUMAN
B:
[26-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
H
P
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
-------
Y
G
L
Y
R
K
M
E
I
Y
R
P
H
K
-----
A
N
A
E
E
M
T
K
Y
H
S
D
D
Y
I
-
K
F
L
R
S
I
R
P
-
D
--
N
--------
M
SEY
S
K
---------------------
Q
-----------------------
M
Q
R
F
N-
V
G
E
-----------
D
C
P
V
F
D
G
L
F
E
F
C
Q
L
S
T
G
G
S
V
A
S
A
V
K
L
N
K
QQ--
T
D
I
-
A
V
N
W
A
G
G
L
--
H
H
A
K
K
S
E
A
S
G
F
C
Y
V
N
D
I
V
L
A
I
L
E
L
L
K
Y
-----
H
Q
R
V
L
Y
I
D
I
D
I
H
H
G
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
S
F
H
-
K
Y
---
G
E--
Y
--
F
P
-
G
T
------------
G
DLRDIGAGKG
K
------------
Y
Y
A
V
N
Y
P
L
R
-
D
G
-
I
D
D
E
S
Y
E
A
I
F
K
P
V
M
235
HHSearch
63.96
23%
-37
- C6 -
-
4ZUR
7
APHA_MYCRA
A:
[23-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
P
F
E
A
P
F
R
A
E
W
I
L
A
A
V
K
E
A
-------
G
F
D
---
D
V
V
A
P
A
R
-----
H
G
L
E
T
V
L
K
V
H
D
A
G
Y
L
-
N
F
L
E
T
A
W
D
-
R
W
K
A
A
GYK----
G
E
A
I
A
T
S
FPVRRTSPRIPTD
I
E
G
Q
I
G
Y
Y
-----------------------
C
-----
N
A
A
-----------
E
T
A
I
S
P
G
T
W
E
A
A
L
S
S
M
A
S
A
I
D
G
A
D
L
I
A
A
GHK-
A
A
F
--
S
L
C
R
P
P
G
--
H
H
A
G
I
D
M
F
G
G
Y
C
F
I
N
N
A
A
V
A
A
Q
R
L
L
D
---
K
-
G
A
K
K
I
A
I
L
D
V
D
F
H
H
G
N
G
T
Q
D
I
F
Y
E
R
G
D
V
F
F
A
S
L
H
-
G
D
---
P
AE-
A
--
F
P
-
H
F
LGYAEETGKGA-
G
----------
A
------------
G
T
T
A
N
Y
P
M
G
-
R
G
-
T
P
Y
S
V
W
G
E
A
L
T
D
S
-
227
HHSearch
60.38
24%
-44
- C6 -
-
5DC8
4
HDAC8_HUMAN
A:
[30-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
K
I
P
K
R
A
S
M
V
H
S
L
I
E
-------
A
Y
A
L
H
K
Q
M
R
I
V
K
P
K
V
-----
A
S
M
E
E
M
A
T
F
H
T
D
A
Y
L
-
Q
H
L
Q
K
V
S
Q
-
E
--
G
--------
D
DDHPD---------------------
S
IEY--------------------
G
-----
L
G
Y
-----------
D
C
P
A
T
E
G
I
F
D
Y
A
A
A
I
G
G
A
T
I
T
A
A
Q
C
L
I
D
GM--
C
K
V
-
A
I
N
W
S
G
G
W
--
A
H
A
K
K
D
E
A
S
G
F
C
Y
L
N
D
A
V
L
G
I
L
R
L
R
R
-----
K
F
E
R
I
L
Y
V
D
L
D
L
H
H
G
D
G
V
E
D
A
F
S
F
T
S
K
V
M
T
V
S
L
H
-
K
F
---
S
PG-
F
--
F
P
-
G
T
------------
G
DVSDVGLGKG
R
------------
Y
Y
S
V
N
V
P
I
Q
-
D
G
-
I
Q
D
E
K
Y
Y
Q
I
C
E
S
V
L
223
HHSearch
58.38
24%
-16
- C6 -
-
1ZZ1
4
HDAH_ALCSD
A:
[31-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
--
I
S
H
H
L
A
H
P
D
T
K
R
R
F
H
E
L
V
C
-------
A
S
G
Q
I
E
H
L
T
P
I
A
A
V
A
-----
A
T
D
A
D
I
L
R
A
H
S
A
A
H
L
-
E
N
M
K
R
V
S
N
-
L
--
P
TG------
G
--------------------------
D
-----------------------
T
-----
G
D
G
-----------
I
T
M
M
G
N
G
G
L
E
I
A
R
L
S
A
G
G
A
V
E
L
T
R
R
V
A
T
GELS
A
G
Y
--
A
L
V
N
P
P
G
--
H
H
A
P
H
N
A
A
M
G
F
C
I
F
N
N
T
S
V
A
A
G
Y
A
R
A
V
--
L
-
G
M
E
R
V
A
I
L
D
W
D
V
H
H
G
N
G
T
Q
D
I
W
W
N
D
P
S
V
L
T
I
S
L
H
-
Q
H
---
L
---
C
--
F
P
P
D
S
GYSTERGAGN--
G
----------
H
------------
G
Y
N
I
N
V
P
L
P
-
P
G
-
S
G
N
A
A
Y
L
H
A
M
D
Q
V
V