@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_02_0100: (2018-03-07 )
MESFLANVDSAHLKARLNKIMADVNAVTSDAAAAAVSAKSSEEAGQCVLEFVKFFVSVAEQHGTTPHAVLGQHVVSNVLIFVLERIVKPNLMTYCRVAEKHAAIAVAASGDTTSPARCRAAKLGSGAASAATGRRDALEARRRRLRRDIIRPFAQLFQSLHTSLAEEGEPLMTWATEGGGRTLGATRRAAALRSGGRHEELLGSASPSYAPPESSSAFGGSRRGEQRAGEWRGRDDVWGTGDSAHEDGLLISGASDALSQAPLLWKSASPLNILCNHILEVLESQWLVAAVGADYAALLIEVLRWSGYARLITPTYLVRLSECLVTLIQRVSTLEEADTDVLTVAPNLVAQAVADGRLWVAAPCADDACLYAQVLMRLCALPQITTAYPPSSSTATDAGMHGGGGAAAALAFVRRVIEVVKARHRAPTPDLRLEAYCIAALRRLCQRFRYDHPIAARAPVEVVKLLCDFFFLLHHTPRHDVWRLETMQFLTVVLSVALSDVVGEELWQDLHAHSRRAAADADAEAAMVSPDAREMVHKAKSSERVGLVGRRGTTGAATAANLLLQPPTRHLVVLIHQSVFPTMQLIFTQHRHEYSFTSRRELFSFPCSPLQEVFDFGAVALYVTSITHGAYCRWKAAQANRCGGSGTTRCGTVADQEKEGAEDDEDEEQIRRHGAGTEARRACKRLRDIEPGYGDVVDGVAMDKAADASGAARTPPPASPHPAQLLADTLQEEFFMPAGPLESSTTAGRAATAGHDVQQRPLQSAATLTRRRAGGAPLVLRIGTSSIRTSSAAVQDVVSDTALFLLHLFAQPCATLRVPETVADRLVEDVLLPLCGHFGLRLGQLLLAAVKAVIPRCSLATQQYAFAVVAQRTLPAVPPALARWAGCLDSVSSSRVPVTRNDEDVLAPPEPVYHVLVVLLEQHLHRRHELGLSTVTPDDPPRNGQSAGAAGSGQPDVSSGRLLSGFLLSWGDHHRALIQRGVARLHAFEQDMRRVCESAGATAVPAGVGGAHDAPLPLLAASLALLLTRFATLVQCTRLWEMTLCPSTAMPVDPGTTEAEPQRCRVVHDDHTWGLSDGPAEDVGLSFLCHVAANATLFLGSVPVLTRASDGGSHAGDVAGGGVRAARQASGIGTDALTATSASLETRNALTGADAVALFSAAQFTAWLDLAETYACVALRMCLARQQVAEQTEMATSLRLGQGPALGGVPSLSTSSGAMTPHLRGPLRREVGAYVEHVCTLLDAAVTSPSSQVPGVLRDAAEAHWMLRLPLRKGTDRTDVQDGSAAAEEGAAMGEDAKADTDAAALGTGVSPLQMTVPRRAALQAFQAMLASSAQASVAWLMRRAQLRHTLAALAPAAVSRREGNRRGGGGPPDTHTAVRPDLDASAMALALSVQCVQLLHLLLRWRRAALWSTPEESAHARDGVHAAGERGAVTPGVAKDAPFLRSAADGTHASAASERAEGAAADFDVGEEASAACEDLRLLRSSPDVYAAPLSLLERFSAAGGGRLYYAVLWLCHHIAAELDHAHAVGAFFPLWTALHVLFRDVGTVLLDPAFACADPRHTIARFTAALTARIFEDGVRGLSRWRPSNPTSREVTHIMAVSLHMSVDTLRTVLWAASRTRIGAYLAEPLADTSAICRTIVTMLRDQHLLDTAGADSCLTGDAARGSGESDAAAVGDILLPSHHRLLERLPFLPTILLALPPLLRLLALIGCLPPPPADSDTGAAGGFQCCRAVVQVLQVLFVRYRYQLGPGLCSGLLCGTVADIRWLDFRRHPATLRDAGERDSQGCSDAAAFLYAHEGRLLELWTAQLTDHSRVDMPVCTPAWQCALLQAAFAVLPRCEPAVAEVLGRFSFEFLAEKSPYEVRHHAALQVGTLFRTFSARRTQVLHTLLTKAREGMLSSTETLCSTSLLALSEAVRAAPELLVDVLYTLLECWATRGFRHHRLVVACLERMSASVLEGARLTAPAGGASLPRSLPYTHLCRMHARPLLFKWLCEYRHPHAALPVECFGYPTQTAFVVQHLDVLSPLALLLLTEATEEQWSLVATRGGGGRCDGASAEGSLYERLVSAYADTLVAKAAEESEHAAEALGAARRRRRTEASGSDATAKQDEATEAESQTDATAVSDAGALHRLAPLCMLLAYFPGIVTQLLVFASHAPVSPFAGDAGGLADLGKARNSREFADWPRRMGHADAAVEHRGSGGGHSSRASASDMTPTWASVAQRCLYWLEAQLNTAEATMLAQGVRLVLTGRRHVSGESPQPTFSAAAARAVLCHPATASSAAEVLLYYLQHRSAWPHKRRAFDVVLAAQADAVMEALIVLHRTTSEVGAPVYGTPEQLQRALSWVAEKITSVPLPMPGLRDPRTRHASSAEGRGSATAEVETTQGLVPRCTSSDLAHWEAYCLALLVPPAAAPNCELHSPVTDMPSARQSVDAAALTDDVMTRFLLQGNSTYLYALLHAVYRSSAALPSLELQFRALQQLSLLTHIATCWCSARVLTEPHALRLVLSHLLHWLRRSPAAAVRRLVCDALLHVWQVARAGRGNAPRHRGWGTTPATQRRHCRLMVARSLAPLTAVSPLISSTWAALCRIDPDLRRSAWQQRVLAYLADTESRRATRIGAETAAEGKERVLARGAISIDEPTDDEAERNEEGAASDGAPGASAGAGAAESEAVSGGCSLPLDGEQWTWSMYEAQRSACLAPLSNPRARGHLLGLQRLLRYVSGHDEEDSDEALEGVPGTVEEHGSNADMDELVPPESCAVSMQLIVEHTSAAPLPSAPLLQDITVAVDSAQALLVRCLHVASVCLRAGHAPPVAAGPTAHRRSRVRTGGSLRPAELSALDVRAVLLDTIQHLYRLCHCNMAALPTEYADAADQFRPLLPGYVAGEDVHGVHTTRLQMLSADSADEQLLAAFRLLRALALCVVLSGEAATLPHCAAAVSSAPSGMGSGSEWLRHEAQRSGSSASTLLAASESALTDDGLPSNQTAEGIVAGMLAQAYAHQLRTLEQLVWCGDADASELGMCALRAWVLCIASGPDGADGAEPPRPAEPPSCFDEAVAQLVASAWRQQLTGPSAAAAAGELVGASGGDQMPSPKARVCYCLQRRLSWVTRSGSCGSRSCRQRATFGTRGAAADTHLRSPSVWAPLRQCPPNQRAFLCRFVLAAANTYGMLKKSLLWAALVPLLMAELRTAEGPTAVPTSSAGSPACDLDGVHAACDSAGSDVRIAEQLLLPVLLHALCLRESEGQRVVRQEWSRQLDRYVFQQAERCAHTARLFLHVLEQCHAVLLRSTRQRGLKGATAASAGRAKATSSFSAAAAAAAAGDGARAEVAPWPSILGSVPSLQDMGECYWLSDIPAARLARAAVRVGEPHLALLFSQLSGESLYGPRTGAAALCGESETTLSAVMLRDGAGAGEAVLAMSSTPYSILFPFARPGDYPSAASVTHTVGAGATRSGGRARDRHDAVRRQTRSFAEDIFDLYASVQGQLELDDVVGVSLMMRLQSVTSAQPHGDGAKWCSWVGSGSALSASLLGSARGRSSGRAIRRVVGYRESGVTPTTSVASGADDSLAAAPSATAAWLDEMRLLEESETHHASGRLWGSDVPRASAAADSGLGGATVEVARPSVALTGEVQERRPDPWAAHLQRAALLLQHGFPSTALDVLLSLQPAERRWEAAERHRSDSGAAERGVADDSVRACSAPGRAAGRGTTELGPEVFLTGAAGETIDAAAGNTDMLSSWTPAHEASLQALLAEAAWKCGRWSCGGGVAGDCPGSCSSECVPRAVLDRLSLRGNTATPESCGASLMPASAGRFYVHLLSAFITLTNGQPLLSMQHVRRAESALRQQLSPTTFVTTVMAAEALHEVRDCAARFLAADAAARKGKAGKPSRGRGAAPKWKQGDRVVELPTWLRSLRGDSVARGSGLDAAELPTARVPSTVDYASRELLDSVRHALCQVYGDREGWYRFVLGATEQALLNRDAAAAHRWLRDWKEQHAEGTGGEGEQASPSPAIVGTAAAEVRERARQLDLVLRTAQVAYGLGRWQEALALLQPAAAAARGEASLAHFNVAPPRTAPWHAPQEPRVIQQLMVWHGELRLLPPSQLVRDPFLSRAAASDSSGACSFLLARLCHTLADDIAARLTSHEHQQLCESVEESKRLKEDLEAQLEAATRPSTGRAAAPLHRPPGVAELDATTGATTTAVLPTLVNIAGVAPLREARGRSAVADAAAGAAAGAAPTVILSEDQLRVIRRRIRELAGDIKRLEDEWQSEKSNFGLYRRSAINAYSRFLQFNQVAQQGAARGVTERTHRGAAALSEVKCLPVDHEEDVVHAVFGFVELWVNAADMEQGGGEVLSKVLDKAVERIPTAVFVPLAGQLTAQLGGQHEGERLAFLVARLARDYPMHVVWPLLALYHGHTFAKSRDVNTLHNVDEAKITAARQLLAGLASAQSTANASSRAGHSASTAALLSTQIRHAQLLSSAYLELAFDRSAATAQVGKRHAICKDFMLIKDACNLAIPPPSSVDPFVTPAVAGGAALAVPHVMRYRNYFTTPGGVNVPKVLQCELSDGTVVRQLLKAGDDLRQDALIEQVFATANRLFRRRSATRPLQIRTFTIVPLAPTAGILQWVEHTIPLGEYLTGRYTGKEEMPGAHERYFPGEPNTRECRIQLQNAPHSRKCQVLLSLYAQFTPALHYFFLEEYLSAQVWVDRQQTFTRSVAASSIVGYTVGLGDRHINNILLHKGTAEVVHIDLGIAFDQNKLLPVPELVPFRLTRNMIDGLGVRGTEGSLRPCAEAAMHLLRGKRELIRTILSSIMHDPLARWAIGSPTHANHIMGADTSVTGAGAVPQESNTRQPAPVRTHGSSADAARTLARIDAKLRGYDGGDMLSVPTHVRKLMEDAQRVESLAVMFPGWSQWV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790....-..2800......2810......2820......2830......2840......2850......2860......2870......2880...-------...2890......2900......2910......2920......2930......2940......2950......2960......2970......2980......2990......3000........3010......3020......3030......3040.......3050......3060......3070......3080......3090......3100..-----------....3110......3120......3130......3140......3150......3160......3170......----3180......3190......3200......3210......3220......3230......3240......3250......3260......3270......3280......3290......3300......3310......3320.....-----.3330......3340......3350......3360........3370......3380......3390......3400-.......3410......3420......3430......3440......3450......3460......3470......3480......3490......3500......3510......3520......3530......3540......3550......3560......3570......3580......3590......3600......3610......3620......3630......3640......3650...--...3660......3670......3680......----------------3690......3700......3710......3720......3730......3740......3750......3760......3770........3780..---....3790......3800......3810......3820......3830......3840......3850------......3860--------.......3870......3880......3890......3900......3910......3920......3930-........3940....------..3950......3960......3970----......3980---......3990--........4000...--...4010......4020......4030......4040.......4050--------------.........4060....--------..4070.....--.4080......4090-----.......4100......--4110......4120......4130.....-----.4140......4150..--------....4160......4170......4180....-..4190......4200..-....4210..--...---.4220......4230......4240......4250......4260.......4270......4280...---------...4290......4300......4310.....------.4320......4330......--4340---.-----.......4350..-....4360......4370--....-.-.4380......--4390--..---......4400......4410....-..4420------.........4430.----------.....4440-----------...-...4450......4460.--....------.4470......4480....-..4490.-----------.....-4500......-4510..-....4520--.--.....4530--------.....-..-.4540......4550...---...------4560......4570......4580......4590........4600......4610......4620......4630......4640......4650......4660-------......4670......-4680------.--------.--------......4690---.......4700......4710......4720......4730......4740---.......4750..-......4760......4770....-------.--.-----..4780......4790......4800......4810.-.-.....-------4820---..--------.------...4830......4840......4850..-----....4860......4870..--..--....4880......4890......4900....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
S
F
L
A
NV
D
S
A
H
L
K
A
R
L
N
K
I
M
A
D
V
N
A
VTSDAA
A
A
A
VSAKSS
E
E
A
G
Q
C
V
L
E
F
V
K
F
F
V
S
V
A
E
QHGTT
P
H
A
V
L
G
Q
H
V
V
S
N
V
L
I
F
V
L
E
R
IVKP
N
L
M
T
Y
C
R
V
A
EKH
A
A
I
A
V
A
ASGDTTSPA
R
C
R
AAKLGSGAASAATG
R
R
D
A
L
E
A
R
R
R
R
L
R
R
D
I
I
R
P
F
A
Q
L
F
Q
S
L
H
T
S
L
A
EEGE
P
L
M
T
W
ATEGGGRTLG
A
T
R
R
A
A
A
L
RSGG
R
H
E
E
L
LGSASPSYAPPESSSAFGGSRRG
E
Q
RAGEWRGRDDVWGTGDSAHED
G
L
L
ISGA
S
D
A
L
S
QAP
L
L
WKSAS
P
L
N
I
L
C
N
H
I
L
E
V
L
ESQ
W
L
V
A
AVG
A
D
Y
A
A
L
L
I
E
V
L
R
WSG
Y
A
R
LI
T
P
T
Y
L
V
R
L
S
E
C
L
V
T
L
I
Q
R
V
S
T
L
E
EADT
D
V
L
T
V
A
P
N
L
V
A
Q
A
VADG
R
L
W
V
AAPCAD
D
A
C
L
Y
A
Q
V
L
M
R
L
CALPQITTAYPPSSSTATDAGMHGG
G
G
A
A
A
A
L
A
F
V
R
R
V
I
E
V
V
K
A
RHRAPTPD
L
R
L
E
A
Y
C
I
A
A
L
R
R
L
C
Q
R
FRYDHPIAAR
A
P
V
E
V
V
K
L
L
C
D
F
F
F
L
LHHTPRH
D
V
W
R
L
E
T
M
Q
F
L
T
V
V
L
S
V
A
L
S
D
V
V
G
E
E
L
W
Q
D
L
H
A
H
S
RRAAADADAEAAMVSP
D
A
R
E
M
V
H
K
AKSSERV
G
L
VGRRGTTG
A
A
T
A
A
N
LLLQPPT
R
H
L
V
V
L
I
H
Q
S
V
F
P
T
M
Q
L
I
F
T
Q
H
R
HEYSFT
S
R
R
E
L
FSFP
C
S
P
L
Q
E
V
F
D
F
G
A
V
A
L
Y
V
T
SITHG
A
Y
C
R
W
KAAQANRCGGSGTTRCGTVADQEKEGAEDD
E
D
E
E
Q
I
R
RHGA
G
T
E
A
R
R
A
C
K
R
L
RDIEPGYGDVVDGVAMDKAADASGAARTPPPASP
H
P
A
Q
L
L
A
D
T
L
Q
E
E
FFMPAGPLESSTTAGRAATAGH
D
V
Q
QR
P
L
Q
S
A
A
T
L
T
R
RRAGGA
P
L
V
L
R
IGTSSIRT
S
S
A
A
V
Q
D
V
V
S
D
T
A
L
F
L
L
H
L
F
AQPCATLR
V
P
E
T
V
A
D
R
L
V
E
D
V
L
L
P
L
C
G
H
F
G
L
R
L
G
Q
L
L
L
A
A
V
K
A
VIPRCSL
A
T
Q
Q
Y
A
F
A
V
V
A
Q
RTLPAV
P
P
A
L
A
R
W
A
G
C
L
D
S
VSSSRVPVTRNDEDVLAPP
E
P
V
Y
H
V
L
V
V
L
L
E
Q
H
L
H
R
R
H
ELGLSTVTPDDPPRNGQSAGAAGSGQPDVSSG
R
L
L
S
G
F
L
LSWG
D
H
H
R
A
L
I
Q
R
G
V
A
R
L
H
A
F
E
Q
D
M
R
R
V
C
E
SAGATAVPAGVGGAHDA
P
L
P
L
L
A
A
S
L
A
L
L
L
T
R
F
A
T
L
V
Q
C
T
R
L
W
E
M
TLCPSTAMPVDPGTTEAEP
Q
R
C
R
V
V
HDDHTWGLSDGP
A
E
D
V
G
L
S
F
L
C
H
V
AAN
A
T
L
F
LGSV
P
V
L
T
RASDGGSHAGDVAGG
G
V
R
A
A
R
QASGIGTDALTATSASLETRNALTG
A
D
A
V
A
L
F
S
A
A
Q
F
T
A
W
L
D
L
A
E
T
Y
A
C
V
A
L
R
M
C
L
A
R
Q
Q
V
A
E
Q
T
E
M
A
T
SLRLGQGPALGGVPSLSTSSGAMTPHLR
G
P
L
R
R
E
V
G
A
Y
V
E
H
V
C
T
L
L
D
A
AVTSPSSQV
P
G
V
L
R
D
AAEA
H
W
M
L
R
LPLRKGTDRTDVQDGSA
A
A
E
EGAAMGEDAKADT
D
A
A
ALGTGVS
P
L
Q
MTV
P
R
R
A
A
L
Q
A
F
Q
A
M
L
ASS
A
Q
A
S
V
A
W
L
M
R
R
A
Q
L
R
H
T
L
A
A
L
A
P
A
A
V
SRREGNRRGGGGPPDTHTAVRPDL
D
A
S
A
M
A
L
A
L
S
V
Q
C
V
Q
L
L
H
L
L
L
R
W
R
R
A
ALWSTPEESAHARDGVHAAGERGAVTPGVAKD
A
P
F
L
R
SAADGTHAS
A
A
S
E
RAEGAAADFDVG
E
E
A
S
A
A
C
E
D
L
R
L
L
RSSPDV
Y
A
A
P
L
S
L
L
E
R
F
SAAGG
G
R
L
Y
Y
A
V
L
W
L
C
H
H
I
A
A
E
LDHAHAV
G
A
F
F
P
L
W
T
A
L
H
V
L
F
R
D
V
G
T
V
L
LDPAFACADP
R
H
T
I
A
R
F
T
A
A
L
T
A
R
I
F
E
D
G
V
R
G
L
S
RWRPSNPTSR
E
V
T
H
I
M
A
V
S
L
H
M
S
V
D
T
L
R
T
V
L
W
AASRT
R
I
G
A
Y
L
AEPLA
D
T
S
A
I
C
R
T
I
V
T
M
L
RDQHLLDTAGADSCLTGDAARGSGES
D
A
A
A
VGDILLP
S
H
H
R
L
L
E
RLP
F
L
P
T
I
L
L
A
L
P
P
L
L
R
L
L
A
L
IGCLPPPPADSDTGAA
G
G
F
Q
C
C
R
A
V
V
Q
V
L
Q
V
L
F
V
R
Y
R
YQL
G
P
G
L
C
S
G
L
L
CGTVA
D
I
R
W
L
DFRRHPA
T
L
RDAGERDSQG
C
S
D
A
A
A
F
L
Y
AHEG
R
L
L
E
L
W
T
A
QLTDHSRVDMPVC
T
P
A
W
Q
C
A
L
L
Q
A
A
F
A
VLPRC
E
P
A
V
A
E
V
L
G
R
F
S
F
E
F
L
AEKSP
Y
E
V
R
H
H
A
A
L
Q
V
G
T
L
F
R
T
F
S
A
R
R
T
Q
V
L
H
T
L
L
T
K
A
R
E
GML
S
S
T
E
T
L
C
S
T
S
L
L
A
L
S
E
A
V
R
A
A
P
E
L
L
V
D
V
L
Y
T
L
L
E
C
W
A
TRGFR
H
H
R
L
V
V
A
C
L
E
R
M
S
A
S
V
LEG
A
R
LTAPAGGASLPRSL
P
Y
T
H
L
C
R
M
HA
R
P
L
L
F
K
W
L
C
EYRHPHAALP
V
E
CFGYP
T
Q
T
A
F
V
V
Q
H
L
D
V
L
S
P
L
A
L
L
L
LTEATEE
Q
W
S
L
V
A
TRGGGGRCDGASAE
G
S
L
Y
E
R
L
V
S
A
Y
A
D
T
L
V
A
K
A
A
E
E
S
E
H
A
A
E
A
L
G
A
A
R
R
R
RRTEASGSDATAKQDEATEAESQTDATAVS
D
A
G
A
L
H
R
L
A
P
L
C
M
L
L
A
Y
F
P
G
I
V
T
Q
L
L
V
F
ASHAPVSPFAGDAG
G
L
A
D
L
G
KARNS
R
E
F
A
D
W
P
R
RMGHA
D
A
A
V
EHRGSGGGHSSRASASDMT
P
T
W
A
S
V
A
Q
R
C
L
Y
W
L
E
A
QL
N
T
A
E
A
T
M
L
A
Q
G
V
R
L
V
L
TGRRHVSGESPQP
T
F
S
A
A
A
A
R
A
V
L
CHPAT
A
S
S
A
A
E
V
L
L
Y
Y
L
Q
HRSAWPHK
R
R
A
F
D
V
V
L
A
A
Q
A
D
A
V
M
E
A
L
I
V
L
HR
T
T
S
EVGAPVYG
T
P
E
Q
L
Q
R
A
L
S
W
V
A
E
K
I
TSVPLPMPGLRDPRTRHASSAEGRGS
A
T
A
E
V
ETTQGLVPRCTSS
D
L
A
H
W
E
A
Y
C
L
A
L
LVPPAAAPNCELHSPVTDMP
S
A
RQSV
D
A
A
A
L
T
D
D
V
M
T
R
F
L
LQGN
S
T
Y
L
Y
A
L
L
H
A
V
Y
R
SSAALP
S
L
E
L
Q
F
R
A
L
Q
Q
L
S
L
L
T
H
I
A
T
C
W
CSARVLTE
P
H
A
L
R
L
V
L
S
H
L
L
H
W
L
RRS
P
A
A
A
V
R
R
L
V
C
D
A
L
L
H
V
W
Q
V
A
RAGRGNAPRHRGWGTT
P
A
T
Q
R
R
H
C
R
L
M
V
A
RSLA
P
L
T
A
V
S
P
L
I
S
S
T
W
A
A
L
CRI
D
P
D
L
R
R
S
A
W
Q
Q
R
V
L
A
Y
L
ADTESRRATRIGAETAAE
G
K
E
R
V
LARG
A
I
SIDEPTD
D
E
A
ERNEEGAASDGAPGASAGAGAAESEAVSGGCSLPLDGEQ
W
T
W
S
M
Y
E
A
Q
R
S
A
CLAPLSNPRAR
G
H
L
L
G
L
Q
R
L
L
R
Y
VSGHDEEDS
D
E
A
LEGVPG
T
V
E
EHGSNA
D
M
D
ELVP
P
E
S
C
A
V
S
M
Q
L
I
V
EHTSAAPLPSA
P
L
L
Q
D
I
T
V
AV
D
S
A
Q
A
L
L
V
R
C
-
L
H
V
A
S
V
C
L
RAGHAPPVAAGP
T
A
H
R
R
S
RVRTGGSLRP
A
E
L
S
A
L
D
V
R
A
V
L
L
D
T
I
Q
H
L
Y
R
L
CHCNMAALP
T
E
YA
D
A
A
D
Q
FRPLLPGYVAGED-------VHG
V
H
T
T
R
L
Q
M
LSADSA
D
E
Q
L
L
A
A
F
R
L
L
R
A
L
A
L
C
V
VLSGEAAT
L
P
H
C
A
A
A
V
SSAPSGMG
S
G
S
E
W
L
R
H
E
A
Q
RSGSSAS
T
L
L
AASESALTDDGLPSNQ
T
A
E
G
I
V
A
G
M
L
A
Q
A
Y
A
H
Q
L
--
R
T
L
E
Q
L
V
WCGDA
D
A
S
E
L
G
M
C
A
L
R
A
W
V
L
CIASGPDGADGAEPP-RPAEP
P
S
C
F
D
E
A
V
A
Q
L
V
A
S
A
W
R
Q
QLTGP
S
A
A
A
AA
G
E
LVGASGGDQMPS
P
K
A
R
V
C
Y
C
L
Q
R
R
L
S
W
-----------
V
TRSGSCG
S
R
S
C
R
QRATFGTRGAAADTHLRSPSVWA
P
L
R
QCPPN
Q
R
A
F
L
C
R
F
V
L
A
A
A
N
T
Y
G
M
L
K
K
S
L
L
W
A
A
L
V
P
----
L
L
M
A
E
L
RTAEGPTAVPTSSAGSPACDLD
G
V
H
A
A
C
DSAGS
D
V
R
I
A
E
Q
L
L
L
P
V
L
L
H
A
L
CLRESEG
Q
R
V
V
R
Q
E
W
S
R
Q
L
D
R
Y
V
F
Q
Q
A
E
R
C
A
H
T
A
R
L
F
L
H
V
L
E
Q
C
H
A
V
L
L
R
S
T
R
Q
RGLKGATAASAGRAKATSSF
S
A
A
A
A
AAAAGDGARAEVA
P
-----
W
P
S
I
L
GSVP
S
L
Q
D
M
G
E
C
Y
WLSDI
P
A
A
R
L
A
R
A
A
--
V
RVGE
P
H
L
A
L
L
F
S
Q
LSGESLYGPRTG
A
A
ALCGESET
T
L
S
A
V
M
--LRDGAGAG
E
A
V
L
A
MSST
P
Y
S
I
L
FPFARPGDYPSAAS
V
T
H
TVGAGATRSGGRA
R
D
R
H
D
A
V
R
R
Q
T
R
S
F
A
E
D
I
F
D
L
Y
A
S
VQG
Q
L
E
L
D
D
V
V
G
V
S
L
M
M
R
L
Q
S
V
TSAQPHGD
G
A
K
W
C
S
WVGSG
S
A
L
S
A
S
L
L
GSARGRSS
G
R
A
I
R
R
V
VGYRESGVTPTTSVASGADDSLAAAP
S
A
T
A
A
W
L
D
E
M
R
L
L
EESETHHASGRLWGSDVPRASAAADSGLGG
A
T
V
E
VARP
S
V
A
L
TG
E
V
Q
ERRPD
P
W
A
A
H
L
Q
R
A
A
L
L
L
QHGF
P
S
T
A
L
D
--
V
L
LSLQ
P
A
E
R
R
W
E
A
A
E
RHRSDSGAAERGVADDS----------------VRACSAPGRAAGRGTTELGP
E
V
F
L
TGAAGE
T
I
DAAAGNTDMLSSWT
P
A
H
E
A
S
L
Q
A
L
L
A
E
A
A
WKCG
R
W
SCGGGVAGDCPGS
C
S
--
S
E
C
V
P
R
A
V
L
D
R
L
SL---RGNTA
T
P
E
SCGASLMPASA
G
R
F
Y
V
H
L
L
S
A
F
I
TLTNGQ
P
L
L
S
M
Q
H
V
R
R
A
E
S
A
L
R
Q
QLSP
T
T
F
V
T
T
V
M
A
A
------
E
A
L
H
E
V
R
D
C
---------
A
A
R
F
L
A
A
D
A
AARKGKAGKPSRGRGAAPKWKQG
D
R
V
V
E
L
P
T
W
L
R
S
LRGDSVARGSGL
D
A
AELPTARVPS
T
---
V
D
Y
A
S
R
E
L
L
D
S
V
R
H
A
L
------
C
Q
V
YGDRE
G
W
Y
R
F
VLGA
T
E
Q
A
L
LN
R
D
----
A
A
A
A
H
R
W
L
R
D
---
W
K
E
Q
HAEG----TGGEGEQASPSP
A
I
V
--G
T
A
A
A
E
V
R
E
R
A
R
Q
L
D
L
V
L
R
T
A
Q
V
A
Y
G
L
G
R
W
Q
E
A
L
-
A
L
LQ
P
A
A
AAA-----------------RGE
A
S
L
A
H
FNVAPPRTA--------PWHAPQ
E
P
R
V
I
--
Q
Q
L
M
V
W
HG
E
L
R
LL
P
------
P
S
Q
L
V
R
D
P
F
L
S
RAAASD--SS
G
A
C
S
F
L
L
A
R
L
C
H
T
L
A
D
D
I
A
A
R
L
T
S
H
E
H
-----
Q
Q
L
C
E
S
V
E
E
S
K
R
L
K
E
D
L
--------
E
A
Q
L
E
AATRPSTGRAAAPLHRPPGV
A
E
LDATT-GA
T
T
T
A
V
L
P
T
L
V
N
I
AGVA-
P
L
R
E
ARGRS
A
--
V
A
D
---AAAGAAAGAA
P
T
V
I
LS
E
D
Q
L
R
V
I
R
R
R
I
R
E
L
A
G
D
I
K
R
L
E
D
E
W
Q
-
S
EKSNFG
L
Y
R
R
S
A
I
N
A
Y
S
R
F
L
Q
F
N
Q
V
---------
A
Q
Q
G
AARGV
T
E
RTHRG
A
A
A
L
SE
V
K
C
LPVDHE
E
------
D
V
V
H
A
V
F
G
F
V
E
L
W
V
N
A
A
D
M
EQ--G
G
-----
G
-----
E
V
L
S
K
V
L
D
K
A
V
E
R-IP
T
A
V
F
VP
L
A
G
Q
L
T
A
Q
LG--GQHE-
G
-
E
R
L
A
F
L
V
A
R
L
A--RD----Y
P
---
M
H
V
V
W
P
L
L
A
L
YHGHTFAKSRDVNT-LHN---------V
D
E
A
K
I
T
A
A
R
Q
L
L
A
----------
G
L
A
S
A
QSTA-----------NAS-SRAGHS
A
S
T
A
A
L
L
S
T
Q
I
R
--
H
A
Q
L
------
L
S
S
A
Y
L
E
LAFDRSA
A
T
A
Q
V-G
K
R
H
A
I
C
-----------
K
D
F
M
L
-
I
K
D
ACNLAIP-PPSSVD-PFVTPAVA--G--G
A
A
L
A
V
P
----------
H
V
M
R
Y
-
R
N-YFTTPGGVNV
P
K
V
L
Q
C
EL---SD
G
------
T
V
V
R
Q
L
L
KAGD
D
L
R
Q
D
A
L
I
E
Q
V
F
A
T
A
N
R
L
F
R
R
--RSATR
P
L
Q
I
R
T
F
T
I
V
PLAP
T
A
G
I
L
Q
W
V
E
H
TI
P
L
G
E
Y
LTGRYTGKEEMPGAHERYFPGEPNT
R
E
C
R
I
Q
LQNAP-------
H
S
R
K
C
Q
V
L
L
S
L
Y
A
Q
F
T
-
P
A
--------
L
--------
H
--------
Y
F
F
L
E
E
Y
L
S
----
A
Q
V
W
V
D
R
Q
Q
T
F
T
R
S
V
A
AS
S
I
V
G
Y
T
VGLGDRH
I
N
N
I
L
LHKGT
A
E
V
V
H
I
D
L
G
----
I
A
FDQNKL-L-PV-PEL
V
P
F
R
L
T
R
N
M
I
DGLG--VRGTE-------G--S-----L
R
P
C
A
E
A
A
M
H
L
L
R
G
K
R
E
L
I
R
T
I
L
S
S
I
M
HD
P
L
A
R
W-AI-G-SPTHA-------NHIM---GA--------D------TSVTGAGAVPQESNTRQPAPVRTHGS
S
A
D
-----
A
A
R
T
L
A
R
I
D
A
K
LRGYD--GG--DM--LSV
P
T
H
V
R
K
L
M
E
D
A
Q
R
V
E
S
L
A
VMFPGW-SQWV
49
Fugue
73.83
16%
3
- C1 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
A
L
R
A
C
L
I
L
T
T
Q
R
E
P
K
-----
E
M
Q
K
P
Q
W
Y
R
H
T
F
E
E
A
E
K
G
F
D
E
T
L
A
K
E
K
GMNRDDR
I
H
G
A
L
L
I
L
N
E
L
V
R
I
S
S
M
E
G
E
-----
R
L
R
E
E
M
E
E
I
T
Q
Q
Q
L
V
H
D
K
Y
C
K
D
L
M
G
F
G
T
K
P
R
H
I
T
P
F
T
S
F
Q
A
V
Q
P
Q
Q
S
N
A
L
V
G
L
L
G
Y
S
S
H
Q
G
L
M
G
F
G
T
S
P
S
P
A
K
S
T
L
V
E
S
R
C
C
R
D
L
M
E
E
K
FD
Q
V
C
Q
W
V
L
K
C
R
N
S
K
N
S
L
I
Q
M
T
I
L
---------------
N
L
L
P
R
-
L
A
A
F
R
P
S
A
F
T
D
T
--
Q
Y
L
Q
D
T
M
N
H
V
L
S
C
V
K
V
L
Y
D
L
S
R
Q
I
P
Q
L
K
K
D
I
Q
D
G
L
L
K
M
L
S
L
V
L
M
H
---
K
-----------
P
L
R
H
P
G
M
P
K
G
L
A
H
Q
L
A
S
P
G
L
T
T
L
P
E
A
S
D
V
G
S
I
T
L
A
L
R
T
L
G
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F
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F
E
G
H
S
L
T
Q
F
V
R
H
C
A
D
H
F
L
N
S
E
H
K
E
I
R
M
E
A
A
R
T
C
SR
L
L
T
P
S
I
H
L
I
S
G
H
A
H
V
V
S
Q
T
A
V
Q
V
V
A
D
V
--
L
S
K
L
L
V
V
G
I
T
D
P
D
P
D
I
R
Y
C
V
L
A
S
L
D
E
-
R
F
D
A
H
L
A
Q
A
E
N
L
Q
A
L
F
V
A
L
N
D
Q
V
F
E
I
R
E
L
A
I
C
T
V
G
R
L
S
S
M
N
P
A
F
V
M
P
F
L
R
K
M
L
I
Q
I
L
T
E
L
E
H
S
G
I
G
R
I
K
E
Q
S
A
R
M
L
G
H
L
V
S
N
A
P
R
L
I
R
P
Y
M
E
P
ILK
A
L
I
L
K
L
K
D
P
D
P
D
P
N
P
G
V
I
N
N
V
L
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50
Fugue
69.50
19%
9
- C1 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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N
L
C
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-
C
P
F
W
51
Fugue
63.82
16%
-2
- C1 -
-
5FVM
-
?
A:
[85-2469]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
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G
W
-
C
S
--
52
Fugue
56.68
16%
-12
- C1 -
-
5DFZ
-
VPS34_YEAST
C:
[4-875]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
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----
T
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C
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Q
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L
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---
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F
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-----------
D
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-------------------
K
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N
I
------
L
N
D
Q
V
R
L
I
N
V
L
R
E
C
C
E
T
I
K
-
R
L
K
D
T
T
A
-----------
K
K
M
E
L
-
L
V
H
L
L
E
T
K
V
R
-
P
L
V
K
V
R
-
P
I
A
L
P
L
----
D
--
P
D
V
L
I
C
D
----------
V
C
P
E
T
-
S
K
-
V
F
K
S
S
L
S
---
P
L
K
I
T
F
K
T
---
T
L
N
------
Q
P
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
--
E
N
--
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
-----
D
T
L
A
S
I
L
S
K
Y
H
G
I
L
G
Y
L
K
L
H
Y
P
D
E
N
A
T
----------------------------------------------------------------------
L
G
----
V
Q
G
W
V
--
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
T
P
D
G
-
H
F
F
H
A
D
F
G
----
Y
I
L
G
Q
D
-----
P
K
-
P
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
GA
E
S
S
N
Y
-------
D
--
K
-----
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
N
I
P
D
I
-
R
I
-
D
-
P
N
G
A
I
-------
L
R
V
R
---
E
R
FNLNMSEE
D
------
A
T
V
H
F
Q
N
L
I
N
D
S
V
N
A
L
L
P
I
V
I
D
H
L
H
N
L
A
Q
-----
Y
W
R
T
------------------------------------------------------
42
HHSearch
50.87
17%
-28
- C1 -
-
5VLR
1
PK3CD_HUMAN
A:
[546-976]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
L
Y
L
L
C
S
W
P
E
L
P
V
L
S
A
L
E
L
L
-----
D
FSFPD
C
H
V
G
S
F
A
I
K
S
L
R
K
-
L
T
D
D
E
L
F
Q
Y
L
L
Q
L
V
Q
V
L
K
--
Y
E
S
Y
-
L
D
C
E
L
T
K
F
L
L
D
R
A
--
L
A
----
N
R
K
I
G
H
F
L
F
W
H
L
R
S
E
M
H
V
P
S
V
A
--------------------------
L
R
F
G
L
I
L
E
----------
A
Y
C
R
G
S
---------------------------
T
H
H
M
K
V
L
M
K
--
Q
G
-
E
------
A
L
S
K
L
K
A
L
N
D
F
-
V
K
L
S
S
Q
K
-
T
P
K
P
Q
T
K
-----------
E
L
M
H
L
C
M
R
Q
E
A
Y
L
E
A
L
--
S
H
L
-
Q
-
S
P
L
D
P
S
T
L
--
L
--
A
-------------------
E
V
C
V
E
-
Q
C
T
F
M
D
S
K
M
K
P
L
W
I
M
Y
S
N
EEA----------
S
V
G
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
M
I
Q
L
M
D
V
L
W
K
Q
--
E
--
G
L
D
L
R
M
T
P
Y
G
C
L
P
T
G
D
R
T
G
L
I
E
V
V
L
R
S
D
T
I
A
N
I
Q
L
N
-----------------------------------------------
F
N
------
K
-
D
A
--------
L
--------
L
--------
N
W
L
K
S
K
N
P
G
-----
E
A
L
D
R
A
I
E
E
F
T
L
S
C
A
G
Y
C
V
A
T
Y
V
L
G
I
G
D
R
H
S
D
N
I
M
I
R
E
-
S
G
Q
L
F
H
I
D
F
G
----
H
F
L
G
N
F
-----
I
N
-
R
E
R
V
P
F
I
L
T
Y
D
F
V
H
V
I
Q
--
Q
G
K
T
N
NSE
K
F
--
E
--
R
-----
F
R
G
Y
C
E
R
A
Y
T
I
L
R
R
H
G
L
L
F
L
H
L
F
A
L
M
R
A
A
G
L
P
E
L
-
S
C
-
S
---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.56
33%
-29
- C1 -
-
5FVM
-
?
A:
[2084-2469]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
G
--
K
P
I
V
R
I
T
----------
H
---
F
-
E
P
-
V
F
T
V
I
S
S
K
Q
R
P
R
R
V
I
I
K
G
---
S
D
G
------
K
D
Y
Q
Y
L
L
K
S
H
E
D
I
R
Q
D
N
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
DP
E
S
F
Q
R
H
L
N
I
Q
Q
Y
P
A
I
P
L
S
P
K
T
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
------------
E
H
R
E
A
S
K
I
P
L
N
I
E
H
R
I
M
L
Q
M
A
P
-------
D
Y
D
N
L
-
T
L
L
Q
K
V
E
V
F
T
-
Y
A
--------
L
D
N
T
KGQ
D
L
Y
--------
K
V
L
W
L
K
S
R
S
----
S
E
S
W
L
D
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
V
H
I
D
F
G
----
D
C
F
E
A
A
I
L
-
R
E
K
Y
-
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
--
V
S
G
I
E
-------
G
--
S
-----
F
R
I
T
C
E
N
V
M
M
V
L
R
D
N
K
E
S
L
M
A
I
L
E
A
F
A
Y
D
P
L
I
N
W
-
G
F
-
D
-
L
P
T
H
A
---------
V
M
EQT
G
I
--------
D
LPLAN
P
S
E
L
L
R
K
G
V
I
S
V
E
D
A
A
K
M
E
L
Q
Q
K
A
E
V
R
N
A
R
-----
A
T
L
V
L
K
R
I
A
D
K
L
T
G
N
D
--
F
P
RC
Q
E
--
L
S
V
P
D
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
G
W
C
S
---
4
PsiBlast_PDB
49.56
29%
-34
- C1 -
-
4JSV
2
B:
[794-1170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
DP
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
VNNTAGDD
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------ALNKK
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
6
PsiBlast_PDB
49.40
29%
-38
- C1 -
-
4JSX
1
B:
[794-1170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
V
N
N
T
AGD
D
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------AL
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
10
PsiBlast_PDB
49.38
29%
-34
- C1 -
-
3JBZ
2
A:
[785-1161]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
V
N
N
T
AGD
D
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------AL
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
3
PsiBlast_PDB
49.27
29%
-35
- C1 -
-
4JSP
1
B:
[794-1170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
DP
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
VNNTAGDD
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------ALNKK
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
48
Fugue
49.25
12%
-1
- C1 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
------
N
A
L
I
G
Y
--
D
V
T
D
V
S
N
V
H
D
D
E
L
E
F
T
R
R
----
R
L
V
T
P
R
M
A
E
V
---
A
G
R
D
P
K
L
Y
----
A
M
H
P
W
V
T
S
K
P
L
P
-----
E
Y
L
L
K
K
I
T
N
N
C
V
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
S
A
D
D
T
P
G
-
T
I
L
Q
S
F
F
T
K
M
ANERD
F
V
L
R
V
CGRDEYL
V
G
E
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
--------
N
G
E
E
I
H
L
V
L
D
T
--
P
P
D
P
A
L
D
E
V
R
K
E
C
D
------
R
K
F
R
V
K
I
R
G
I
D
I
P
V
L
P
R
--
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
-----
Q
Q
V
L
C
Q
R
R
T
-----
S
P
--
K
P
F
T
E
E
V
L
W
N
V
W
L
--------
E
F
S
I
K
I
K
D
L
P
K
G
A
L
L
N
L
Q
I
Y
C
Q
-------
L
L
Y
-
Y
V
N
L
L
L
I
D
H
R
F
L
L
R
H
G
E
Y
-
V
L
H
M
W
Q
L
S
G
F
--
N
A
D
---
K
L
T
S
A
T
N
P
D
K
E
N
S
M
S
I
S
I
L
L
D
N
H
P
I
A
L
E
M
P
N
Q
L
R
K
Q
L
E
A
I
I
A
T
D
P
L
N
P
L
T
A
E
D
K
E
L
L
W
H
F
R
Y
E
S
L
K
D
P
K
---------
A
Y
P
K
L
F
S
S
V
K
W
G
Q
Q
E
I
V
A
K
T
Y
Q
L
L
A
K
R
E
V
W
D
Q
------
S
A
L
D
V
G
L
T
M
Q
L
L
D
C
N
F
S
D
------------------
E
N
V
R
A
I
A
V
Q
K
L
E
S
-
L
E
D
D
D
V
L
H
Y
L
L
Q
L
V
Q
A
V
K
FE
P
Y
H
D
-
S
-
A
L
A
R
F
L
L
K
R
G
L
R
N
K
R
----
I
G
---
H
F
L
F
W
F
L
R
S
E
I
A
Q
-------------------------
S
R
H
Y
Q
Q
R
F
A
V
I
L
E
----------
A
Y
L
R
G
-----------------------
C
G
T
A
M
L
H
D
F
T
Q
Q
V
Q
--
V
I
D
M
------
L
Q
K
V
T
I
D
I
K
S
L
S
A
E
K
Y
D
V
S
-
S
Q
V
I
S
Q
L
-----------
K
Q
K
L
E
-
N
L
Q
N
L
N
L
P
Q
S
-
F
R
V
P
Y
D
-
P
G
L
K
A
G
A
L
--
V
--
I
E
K
C
K
V
M
----------
A
S
K
K
K
-
P
L
-
W
L
E
F
K
C
A
D
P
T
A
L
----------
S
N
------
E
T
I
G
I
I
F
K
H
G
D
D
L
R
Q
D
M
L
I
L
Q
I
L
R
I
M
E
S
I
W
E
T
--
E
S
--
L
D
L
C
L
L
P
Y
G
C
I
S
T
G
D
K
I
G
M
I
E
I
V
K
D
A
T
T
I
A
K
I
Q
Q
S
T
V
G
N
T
G
A
F
K
----------------------------------------------
D
-
E
V
--------
L
--------
S
--------
H
W
L
K
E
K
C
P
I
----
E
E
K
F
Q
A
A
V
E
R
F
V
Y
S
C
A
G
Y
C
V
A
T
F
V
L
G
I
G
D
R
H
N
D
N
I
M
I
S
E
-
T
G
N
L
F
H
I
D
F
G
--------------------
H
V
P
F
V
L
T
P
D
F
L
F
V
M
G
--
T
S
G
K
K
-------
T
--
S
L
H
F
Q
K
F
Q
D
V
C
V
K
A
Y
L
A
L
R
H
H
T
N
L
L
I
I
L
F
S
M
M
L
M
T
G
M
P
Q
L
-
T
S
-
K
E
D
I
E
Y
I
-------
R
D
A
L
---
T
V
--------
G
------
K
S
E
E
D
A
K
K
Y
F
L
D
Q
I
E
V
C
R
D
K
G
W
T
V
Q
F
N
W
F
-----
L
H
L
V
L
-----------------------------------------------------
7
PsiBlast_PDB
49.10
29%
-39
- C1 -
-
4JT5
1
B:
[794-1170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
V
N
N
T
AGD
D
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------AL
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
8
PsiBlast_PDB
48.75
29%
-35
- C1 -
-
4JT6
1
B:
[794-1170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
-
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
-----------
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
V
N
N
T
AGD
D
L
--------
A
--------
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
L
M
D
-
T
N
T
--------------------------------------------------------------AL
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FS
H
D
--
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
2
PsiBlast_PDB
47.04
28%
-21
- C1 -
-
5H64
-
MTOR_HUMAN
A:
[2169-2545]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
K
L
T
L
M
G
---
S
N
G
------
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
------------
E
H
R
I
M
L
R
M
A
P
-------
D
Y
D
H
L
-
T
L
M
Q
K
V
E
V
F
E
-
H
A
--------
V
--------
N
N
TAGDD
L
A
K
L
L
W
L
K
S
P
S
----
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
DCFE
V
A
M
T
R
E
K
F
------
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
--
V
T
G
L
D
-------
G
--
N
-----
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
-
D
-
T
N
T
--------------------------------------------------------------A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
--
F
S
HD
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
-----
39
HHSearch
46.51
17%
12
- C1 -
-
4JPS
1
PK3CA_HUMAN
A:
[581-1017]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
Y
C
L
V
K
D
W
P
P
I
K
P
E
Q
A
M
E
L
L
DCNYP
D
-----
P
M
V
R
G
F
A
V
R
C
L
E
K
Y
L
T
D
D
K
L
S
Q
Y
L
I
Q
L
V
Q
V
L
K
--
Y
E
Q
Y
L
D
-
N
L
L
V
R
F
L
L
K
K
A
--
L
T
----
N
Q
R
I
G
H
F
F
F
W
H
L
K
S
E
M
H
N
K
T
V
----
S
----------------------
Q
R
F
G
L
L
L
E
----------
S
Y
C
R
A
C
---------------------------
G
M
Y
L
K
H
L
N
R
--
Q
V
-
E
------
A
M
E
K
L
I
N
L
T
D
I
L
K
Q
E
K
K
D
E
-
T
Q
K
V
Q
M
K
-----------
F
L
V
E
Q
-
M
R
R
-
P
D
F
M
D
A
-
L
Q
G
F
-
L
-
S
P
L
N
P
A
H
-----------------------
Q
L
G
N
L
-
R
L
E
E
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
---
P
D
I
MSELLF
Q
N
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
--
Q
--
G
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
C
K
-----------------------------------------------
F
------
N
S
-
H
T
--------
L
--------
H
--------
Q
W
L
K
D
K
N
K
G
-----
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
K
D
-
D
G
Q
L
F
H
I
D
F
G
----
H
F
L
D
H
K
K
K
K
F
G
Y
K
-
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
--
K
G
A
Q
E
CTKT
R
E
F
E
--
R
-----
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
G
M
P
E
L
-
Q
S
-
F
-
D
-------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
43.97
23%
-8
* C1 *
-
4UWH
1
PK3C3_HUMAN
A:
[259-557]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
R
S
L
L
A
--
A
Q
Q
T
------
F
V
D
R
L
V
H
L
M
K
A
V
Q
R
E
S
G
N
R
K
K
K
N
E
R
L
Q
-----------
A
L
----
L
G
D
N
E
K
M
N
L
S
D
V
E
L
I
-
P
-
L
P
L
E
P
-------------
Q
V
----------
K
I
R
G
I
-
I
P
E
T
A
T
L
F
K
S
A
L
M
P
A
Q
L
F
F
K
T
---
E
D
G
------
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
--
E
--
N
L
D
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
S
-
V
P
V
A
E
V
L
D
T
E
--------
G
------------------------------------------------
S
--------
I
--------
Q
--------
N
F
F
R
K
Y
A
P
S
ENGP
N
G
I
S
A
E
V
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
-
K
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
-----
P
K
-
P
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
--
G
T
Q
S
E
-------
Q
Y
Q
E
-----
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
Y
S
N
L
I
L
N
L
F
S
L
M
V
D
A
N
I
P
D
I
-
A
L
-
E
-
P
-------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
43.96
24%
-103
- C1 -
-
4UWK
1
PK3C3_HUMAN
A:
[339-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
A
Q
L
F
F
K
T
---
E
D
G
------
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
--
E
N
L
D
--
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
----
E
G
S
I
Q
N
F
F
R
K
Y
A
P
S
E
-----------
N
G
P
-------
N
G
--------------------------------------------------
I
S
----
A
E
V
----
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
-
P
-----
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
----
G
T
Q
-------
S
--
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
43.61
24%
-99
- C1 -
-
4OYS
1
PK3C3_HUMAN
A:
[339-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
A
Q
L
F
F
K
T
---
E
D
G
------
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
--
E
N
L
D
--
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
----
E
G
S
I
Q
N
F
F
R
K
Y
A
P
S
E
-----------
N
G
P
-------
N
G
--------------------------------------------------
I
S
----
A
E
V
----
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
-
P
-----
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
----
G
T
Q
-------
S
--
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
43.54
24%
-101
- C1 -
-
3LS8
2
PK3C3_HUMAN
A:
[352-546]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
A
Q
L
F
F
K
T
---
E
D
G
------
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
--
E
N
L
D
--
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
----
E
G
S
I
Q
N
F
F
R
K
Y
A
P
S
E
-----------
N
G
P
-------
N
G
--------------------------------------------------
I
S
----
A
E
V
----
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
-
P
-----
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
----
G
T
Q
-------
S
--
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
43.48
24%
-96
- C1 -
-
4UWF
1
PK3C3_HUMAN
A:
[339-533]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
A
Q
L
F
F
K
T
---
E
D
G
------
G
K
Y
P
V
I
F
K
H
G
D
D
L
R
Q
D
Q
L
I
L
Q
I
I
S
L
M
D
K
L
L
R
K
--
E
N
L
D
--
L
K
L
T
P
Y
K
V
L
A
T
S
T
K
H
G
F
M
Q
F
I
Q
-
S
V
P
V
A
E
V
L
D
T
----
E
G
S
I
Q
N
F
F
R
K
Y
A
P
S
E
-----------
N
G
P
-------
N
G
--------------------------------------------------
I
S
----
A
E
V
----
M
D
T
Y
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
L
T
K
-
T
G
K
L
F
H
I
D
F
G
----
Y
I
L
G
R
D
P
K
-
P
-----
L
P
P
P
M
K
L
N
K
E
M
V
E
G
M
G
----
G
T
Q
-------
S
--
E
Q
Y
Q
E
F
R
K
Q
C
Y
T
A
F
L
H
L
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------