@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_04_0650: (2018-03-07 )
MTRTPSSLAPLPLSSFKQLSMNAPVQERSGTSSSNAPPAHKKQRHEGGCSGKVLDDRDADSVRVWGVLVAQNLPSRENGLLAHAPRCRCPVEGADAPGKESVTKLIASSSLREPEEDWLWRHVPPALRQFYFPVCSHSGSTYPCAPASAECSEKCWAASLQQEGDKSHPSPSPRLLLPLCGTRSNNGAVRLGRLASNGIVFATNPCVSNVHCTIAYQPGSDPRRGDAAAAATVAAEDKEAQRAAYEAAGAVAKVVAPLHRSPQPATDAPAAPHPRGDATGRNAARIMLSDYSTNGCIVNGQKVGKGRSARLRDGDVVELINAGPRRTTDYNLSFLFLTAEAFVRWVAEQPHQASTTQGADEDIALAEKEQQQRQALQTAARRRALLCRAQWNVEAQVRRMYGHSVDEYYSLDRAHPLGQGTFGTVYRAALRAEASASSQSPSLLDAGGGVAAGVPSSWEYVFSGDGVGEWTANPAEAAELREAYIRGKERRAPASVLHVSASAASTTAAEADAITTDDAAPQVFAVKIIRKQRMLFEALQQQQQQQHVEEGEGGTDRAPVSCIRNAATVATPGTAGAVPGTISAADAAVIEQLLLMETQPDDLAAQRRKEWTAGVLASLQLADLTPAALTPSSSLSAFRKSQHKPRDDDDSSDDGDAQPLSQQDREQRRRELIRCLPEALRRTYERELQHRRRQQREINILLAVRHRNVTALYEVFDQPDHLALVMEQATGGEVWDLLQIYKRRERGGKTGARKSERGANNHRNAGAQRLGDGKSNSTTAAATAATCDDDDDVELVSVGGPLPEFIVKIIIVQVIEAVLYLHTMGIIHRDLKLENLMLQRPCDRYALNALQLQTLVHQLRAYSHSHHASDASTSAATTCEEDSEAVEFTNPLSVLYTVHVPRHMWPVVKIMDFGLSHVLDHLQTHPFDSAGALHGFAGTLSQMSQGVEGRSAAAASAATEAVPERVKLIYSRNDATTSCGTPIYAAPEVTNPALRPDKMGYGAAVDMYSVGVIAYALLTGRAPFPSAKNPRRPGGPPVVNYDAPLRFQRHRRRPAVPKGATGPPASAGPLPSSRPSSSAARPPSEVACLPPLSVVESVRVVLPKERAETSAAFSAASEQTRQWHRRAEAVAASVRCAEQKRALAEGSDGGSSATPADTLFATTVEQLCASLTAYADMCASGGLEVDLDRLVYVSADAAATGVQANASVGRVMAPDGHVADVLLPPISALGTSFLRGLLEKYPSRRLTAYEALRHPWLRECV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640...--....650.......660.......670......------------------.680...-....690.......700..-.....710....--..----.------720---........730.......740..--.....750.......760.......770.......780......-.790.......800........810.......820.-..--....830.......840.---....------..850.......860.......870.......880.......890.......900------------.........910.......920.......930.......940.......950.......960.......970.......980.....--..990......--.1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130..--....1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTRTPSSLAPL
P
L
S
S
F
K
Q
LSMNAPVQERSGTSSSNAPPA
H
K
K
Q
RHEGGCSGKVLDDRDADS
V
R
V
W
G
V
L
V
A
QNLPSRENGLLAHAPRCRCPVEGADAP
G
K
E
S
V
T
K
L
I
A
S
SSLREP
E
E
D
W
L
WRHV
P
P
A
L
R
Q
F
Y
F
P
V
CSHSGSTYPCAPAS
A
E
C
S
E
K
C
W
A
A
S
L
Q
QEGDKSHPSPSP
R
L
L
L
P
LCGTRSNNG
A
V
R
L
G
R
LASN
G
I
V
F
ATNPCVSN
V
H
C
T
I
A
YQPGSDPRRGD
A
A
A
A
A
T
VAAE
D
K
E
A
Q
R
A
A
Y
E
A
A
G
A
V
A
K
V
V
A
P
L
HRSPQPATDAPAAPHPRGDATGR
N
A
A
R
I
M
L
SDYSTN
G
C
I
VNGQKVGKGRSARLRDG
D
V
V
E
L
INAGPRRTTDY
N
L
S
F
L
F
L
T
A
E
A
F
V
R
W
V
A
EQPHQASTTQGADE
D
I
A
L
A
E
K
E
Q
Q
Q
R
Q
A
L
Q
T
A
A
R
R
R
A
L
L
C
RAQW
N
V
E
A
Q
V
R
R
M
YGH
S
V
D
E
Y
YSLDRAHPLGQG
T
F
G
T
V
Y
R
A
A
L
RAEASASSQSP
S
L
LDAGGGVAAGVPSS
W
E
Y
V
F
SGDGVGEWTAN
P
A
E
A
A
E
L
R
E
A
Y
IRGKERRAP
A
S
V
L
H
V
SASAASTTAAEADAITTDDAAPQ
V
F
A
V
K
I
I
R
K
Q
R
M
L
F
E
A
L
Q
Q
Q
Q
Q
Q
Q
H
V
EEGEGGTDR
A
P
V
S
C
I
RNAATVATPGTAGAVPGTIS
A
A
D
A
A
V
I
E
Q
L
L
L
METQ
P
D
D
L
A
A
Q
R
R
K
E
W
T
A
G
V
L
A
S
L
Q
LADLTPAALTP
S
S
S
L
S
A
F
R
K
SQHKP--RDDDDSSDDGDAQP
L
S
Q
Q
D
R
E
Q
R
R
R
E
L
I
R
C
L
P
E
------------------
A
L
R
R
T
Y
E
-
R
E
L
Q
H
R
R
R
Q
Q
RE
I
N
I
L
L
A
V
-RHR
N
V
T
A
L
Y
E
V
F--DQ----P------
D
H
----
L
A
L
V
M
EQATGG
E
V
W
D
L
L
Q
I
Y
K
R
R
--ERGGKTGARKSERGANNHRNA
G
A
Q
RLGDGKSNS
T
T
A
A
A
T
A
ATCD-DDD
D
V
E
L
V
SVGGP-
L
P
E
F
I
V
K
I
I
I
V
Q
V
I
E
A
V
L
Y
L
H
T
-
M
G
--
I
I
H
R
D
L
K
L
E
N
L
M
L
QR
P
C
D
---
R
Y
A
L
------
N
A
L
Q
L
Q
T
L
V
H
Q
L
R
A
Y
SHSHHASDASTSAATTCEEDSE
A
V
EFTNP
L
S
V
L
Y
T
VHV--------------
P
R
H
M
W
P
V
V
K
I
M
D
F
G
L
S
H
V
L
D
H
L
QTHPFDSAG
A
L
H
G
F
A
G
T
L
S
Q
M
S
QGVEGRSAAA
A
S
A
A
T
E
A
V
P
E
R
V
K
L
I
Y
SRNDATTSCGTPIYAAP--EVTNPALRPDK--MGYGA
A
V
D
M
Y
S
V
G
V
I
A
Y
A
L
L
TGRAPFPSAKNPRRPGGP
P
V
VNYDAP
L
R
F
Q
R
HRRRPAVPKGATGPPASAGPLPSSRPSSSAARPPSEVACLP
P
L
S
V
V
E
S
V
R
V
VLPKERAE
T
S
A
A
F
S
A
A
S
E
Q
T
R
Q
W
H
R
R
A
E
A
V
A
A
S
V
R
--
C
A
E
Q
K
R
A
LAEGSDGGSSATP
A
D
T
L
F
A
T
T
V
E
Q
L
C
A
S
L
T
A
Y
A
D
M
C
ASGG
L
E
V
D
L
D
R
L
V
Y
V
SADAAATGVQANASVG
R
V
MAPDG
H
V
A
D
V
LLP
P
I
S
A
L
G
T
S
F
L
R
G
L
L
E
KYPSR
R
L
T
A
Y
E
A
L
R
H
P
W
L
R
ECV
35
HHSearch
78.83
31%
-107
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[14-222]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
------------------
R
R
T
K
S
S
--
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
----
K
------
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------------------------------------------------------------
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-----------------------------------------------------------------------------------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
--------------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
--
E
I
V
N
Y
--------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.36
32%
-62
- C1 -
-
4GV1
4
AKT1_HUMAN
A:
[15-217]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
------------------
E
V
I
-----
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
----
H
------
D
R
----
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-------------------------------------------------------------
R
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
--
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---------------------------------------------------------------------------------------
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
-------------------------------------------------
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
--
E
V
L
E
D
--------
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
78.31
31%
-106
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[12-220]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
--
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
------------------
R
R
T
K
S
S
--
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
N
----
K
------
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------------------------------------------------------------
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
-----------------------------------------------------------------------------------
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
--------------------------------------------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
--
E
I
V
N
Y
--------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
77.67
29%
-121
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[10-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
------------------
K
K
L
------
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
--
S
E
----
E
------
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-------------------------------------------------------------
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
--
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
------------------------------------------------------------------------------------
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
-------------------------------------------------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
--
E
V
L
R
K
--------
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
75.49
18%
29
- C1 -
-
1KOB
1
?
A:
[23-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
--
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
GAF
G
V
V
H
R
C
V
EKATG
R
V
F
V
A
K
F
I
N
T
-
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
--
E
D
----
K
------
Y
E
----
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
------------------------------------------------------------
A
A
E
D
Y
K
-
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
A
-------------------------------------------------------------------------------------
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
--------------------------------------------------
P
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
--
E
I
V
D
------
R
--
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
-----------
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
FS
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------
37
HHSearch
72.41
26%
-98
- C1 -
-
5IU2
1
M3K8_HUMAN
B:
[80-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
------------------
D
-------------
Q
F
K
P
S
D
V
E
I
Q
A
C
F
-
R
H
E
N
I
A
E
L
Y
G
A
V
--
L
W
----
G
------
E
T
----
V
H
L
F
M
E
A
G
E
G
G
S
V
L
E
K
L
E
S
C
-------------------------------------------------------------
G
P
-
M
R
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
-
K
K
--
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
----------------------------------------------------------------------------------------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
V
-------------------------------------------------
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
--
E
V
I
L
C
--------
R
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
71.15
25%
-130
- C1 -
-
1KOB
1
?
A:
[58-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
------------------
P
Y
--------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
--
E
D
----
K
------
Y
E
----
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
------------------------------------------------------------
Y
K
-
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
K
-------------------------------------------------------------------------------------
A
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
--------------------------------------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
--
E
I
V
D
R
--------
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
70.32
24%
-133
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[23-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
Y
--
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
------------------
A
K
F
--
T
S
-
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
----
D
------
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
---------------------------------------------------------
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
------------------------------------------------------------------------------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
-------------------------------------------------
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
--
E
V
V
K
R
--------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
70.23
25%
-132
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
--
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
------------------
A
K
F
--
T
S
-
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
----
D
------
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
---------------------------------------------------------
G
F
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
--
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
------------------------------------------------------------------------------------
S
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
--
E
V
V
K
R
--------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
69.94
26%
-124
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[24-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
------------------
K
---------
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
--
E
S
----
M
------
E
E
----
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
------------------------------------------------------------
F
E
-
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
R
-------------------------------------------------------------------------------------
S
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
--------------------------------------------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
--
E
V
H
Q
H
--------
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
69.26
26%
-106
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[12-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
------------------
E
P
--------
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
--
L
R
----
R
------
D
K
----
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
-------------------------------------------------------------
G
P
-
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
---------------------------------------------------------------------------------------
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
-------------------------------------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
--
E
V
A
A
V
E
---
R
K
--
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
68.62
26%
-93
- C1 -
-
4Y85
1
M3K8_HUMAN
B:
[80-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
P
R
G
A
F
G
K
V
Y
L
A
Q
D
I
K
T
K
K
R
M
A
C
K
L
I
P
V
------------------
D
-------------
Q
F
K
P
S
D
V
E
I
Q
A
C
F
-
R
H
E
N
I
A
E
L
Y
G
A
V
--
L
W
----
G
------
E
T
----
V
H
L
F
M
E
A
G
E
G
G
S
V
L
E
K
L
E
S
C
-------------------------------------------------------------
G
P
-
M
R
E
F
E
I
I
W
V
T
K
H
V
L
K
G
L
D
F
L
H
S
-
K
K
--
V
I
H
H
D
I
K
P
S
N
I
V
F
M
S
T
----------------------------------------------------------------------------------------
K
A
V
L
V
D
F
G
L
S
V
Q
M
T
E
D
V
-------------------------------------------------
Y
F
P
K
D
L
R
G
T
E
I
Y
M
S
P
--
E
V
I
L
C
--------
R
G
H
S
T
K
A
D
I
Y
S
L
G
A
T
L
I
H
M
Q
T
G
T
P
P
W
V
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
67.67
27%
-119
- C1 -
-
4BGQ
2
CDKL5_HUMAN
A:
[14-215]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------------------------------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
-
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
R
----
R
------
G
K
----
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
-------------------------------------------------------------
N
G
-
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
-
N
D
--
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
---------------------------------------------------------------------------------------
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------------------------------------------------
T
R
W
Y
R
S
P
--
E
L
L
L
G
--------
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
67.54
24%
-29
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[60-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
------------------
D
------------
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
--
Y
S
----
S
GEKKD
E
V
Y
----
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
----------------------------------------------------------
A
K
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
-
F
G
--
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
--------------------------------------------------------------------------------------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
--------------------------------------------------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
--
E
L
I
F
G
-----
A
--
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
67.39
29%
-14
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[101-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
------------------
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
--
E
S
----
S
------
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-------------------------------------------------------------
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
---------------------------------------------------------------------------------------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
--
E
I
L
K
C
S
M
D
E
T
H
--
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
67.32
29%
-19
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[101-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---------------------
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
--
E
S
----
S
------
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-------------------------------------------------------------
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
--
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
---------------------------------------------------------------------------------------
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
--------------------------------------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
--
E
I
L
K
C
S
M
D
E
T
H
--
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
63.96
25%
-37
- C1 -
-
5O2C
4
WNK3_HUMAN
A:
[26-231]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
--
K
F
D
I
E
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
V
E
V
A
W
C
E
L
Q
D
------------------
R
K
L
------
T
K
A
E
Q
Q
R
F
K
E
E
A
E
M
L
K
G
L
-
Q
H
P
N
I
V
R
F
Y
D
S
W
--
E
S
I
L
KG
K
------
K
C
----
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
R
F
-------------------------------------------------------------
K
V
-
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
-
R
T
PP
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
--------------------------------------------------------------------------------------
G
S
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
---------------------------------------------------
F
A
K
S
V
I
G
T
P
E
F
M
A
P
--
E
M
Y
E
---------
E
H
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
63.80
25%
-112
* C1 *
-
4XBR
1
INKA1_HUMAN
A:
[102-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
------------------
R
K
--------
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
----
G
------
D
E
----
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
--------------------------------------------------------------
R
-
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---------------------------------------------------------------------------------------
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
-------------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
--
E
L
I
S
R
--------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
60.96
15%
-9
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
--
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
------------------
I
S
F
L
-------
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
----
T
------
R
H
----
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
--
E
P
S
--
N
A
Y
G
-------------------------------------------------------
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
-
N
G
--
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
G
Q
S
V
Y
K
L
T
DFGA
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
GSLPFRPFEGPRRN
K
E
V
M
Y
K
I
I
T
G
K
P
S
G
A
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
V
S
C
S
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
G
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
QM
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
59.98
12%
34
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
-
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
LI
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
------------------
Y
L
S
V
A
P
F
-
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
-
R
Q
P
V
T
K
N
T
F
R
Q
Y
--
R
V
----
L
------
G
K
GGF
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
R
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
-
G
---
H
I
R
I
------
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
GQSPFQQ-------
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
-------
L
E
P
P
F
K
P
--
D
P
Q
A
I
Y
C
E
P
T
D
--
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------