@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_07_1050: (2018-03-08 )
MDSASGISGSACGSRHNRPRVFCVVCGSCSEHLILRKSGLKCASCVGKSSNKHYAKLQKRQAKKLFSNAFPAQSPTAGLDTASSVQPGDCSQTNRLFSSASSSLPPAVEDYSGTAGVSTERSSTLHPIEEYISGTSVYRAVMEQACYSGENDRSGGEGGSGDRQTLMSGADGVTRSTSDALSKAHQENTASGSHTNVSSSAAAGDNAGDMRRTSPPLMTQRQESGDAQCSDPGSAKSGRDGVGKTPLCRDSSLIPPTPILDKVTEKEANNQAPARCYKTAPSRLPPRHGPRVTKGTPRLPPSAVDVSRVSAAHTVSAKSNGKATGTSSLNGATASPPSSAIKAVPAAARCVEGQDLMPESGNSVLRDATLPPAEPAAGQHHSHPSTPRGDEGTTPLAASLSQNPTHPPQVLRASRQSPTTFPDASLGLPAPRAGSCNTSITSSTMERGPASRLPLLHSHADSNAGTQVQRDSQGGTRRLSAAPSTVSTLPNTSVRPVDAPGAAGAGAPSLSRMPNSSGATAAALDNCHSVGSSSRCRHNKRGSRGGSSGDSESSSSSLSDDASAIDSSLPSVVSSATPEAVIGEDGAATSGTGTKKALHGGTNALDVGTKKRTRQVPKSVDSTMEKKGAGGSAGHGLATTPLSGYIDALHITVESVQPPLLNGPETTTFAPCGGDELPQAATSYNDESSTTTGDTHSRCDSIRSGSFRTNDGYQRQVYVVGQSGNFKVTRHIRQCSGSSDVLAGRSSAAVASSASGTLTATRLRGRQQHGSSGDTMGTGAVEVKRISYRIIVKNRCSGEVLLTQERRLYTQIIPALERVKAIAGGELPAVPVKRLPSLRFATEVFTEERRAEVEAFLQAVALSPFYVRHPEVVKLLGLELYVTDAGAAAATGAAAAKGSRGNGADAHRPSKSPRAMHTKSSPSMGVGADIEVTPLARRGAACDSKYLSRHSRDGEAGVRAAAATGRGEAGTGCLTVDALNAYCSLTMGGGGGDTADSRNFCRSQSCSSVQTSCSSVVRRRKLDEVTMEDLEHIQLGNLIGRGTFGSVYLGLVQTQRGSLMVAVKVMKVGEAVAPSEMESLQRELDVLCAARHKNIIRFLGSSLNTTTRDLRVFTEYVECGTIRSLVDRFGALTMLAIQQYMQQILSGLQYLHSLSIAHRDIKGENILVTKNGRIKLSDFGSSTGAPCKVVAAAESPSKGGSGGSADSAANGGLPVGSPQYMAPEVIHGTVKSFAAVDIWSLGCVGIEMMDRPIWRESPSTNPFVFLYRISRCGTPPHGLPTDDELAALKAEGKKTECEGFSVYLEFLRSCLRVDPEQRPSAAELLKHPFMTYPYSKHLRWMPPMPATAKPSALKSS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870......--.880.......890.......900.......910.......920.......930.---......940.......950.......960....-...970--.......980...----....990.......1000-.....------------....1010....-------..1020......1030......1040......1050.......1060......1070......1080......1090......1100......1110......1120......1130--........1140......1150..-....1160......1170......1180......1190......1200......1210......1220.....--.1230----.-.....1240......--1250......--.1260........1270......1280......1290---------........-1300.----.-.....1310--........-----.-----1320.---.....1330.....---.---1340.-.....1350...---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDSASGISGSACGSRHNR
P
R
V
F
C
V
VCGSCSE
H
L
I
L
RKSGL
K
C
A
S
C
VGKSSN
K
H
Y
A
K
L
Q
K
R
Q
A
K
K
L
F
SNAFPAQSPTAGLDTASSVQPGD
C
S
Q
T
N
R
L
F
S
SASSSLPP
A
V
EDYSGTAGVSTERSST
L
H
P
I
E
E
YIS
G
T
S
V
Y
R
A
V
M
E
Q
ACYSGENDRSGGEGGSG
D
R
Q
T
L
M
SGADGVTRS
T
S
D
A
L
S
K
A
H
QENTASGSHTNVSSSAAAGDNAGDMRRTSPP
L
M
T
Q
RQESGDAQCSDPGSAKSGRDGVGKTPLCRDSSLIPPT
P
I
L
D
K
V
T
E
KEANNQAP
A
R
C
YKTAPSRLPPRHGPRVTKGTPRLPPSAV
D
V
S
RVS
A
A
H
T
V
SAKSNGKATGTSSLNGATASP
P
S
S
A
I
K
AV
P
A
A
A
RCVEGQDLMPESGNSVLRDATLPPAEPAAGQHHSHPSTPRGDEGTT
P
L
A
A
SLSQNPTH
P
P
Q
V
L
R
ASRQSPTTFPDASLGLPAPRAGSCNTSI
T
S
S
T
MERGPASRL
P
L
L
HSHADSNAGT
Q
V
Q
RDSQGGTRRLSAAPS
T
V
STLPNTSVRPVDAPGAAGAGAP
S
L
SRMPNSSGA
T
A
A
A
L
D
N
C
H
SVGSSSRCRHNKRGSRGGSSGDSESSSSSLS
D
D
A
S
A
I
D
S
S
L
P
S
V
V
S
SATP
E
A
V
IGEDGAATSGTGT
K
K
A
LHGGTN
A
L
DVGT
K
K
R
T
R
QV
P
K
S
V
D
S
T
M
E
KKGAGGSAGHGLATTPLSG
Y
I
D
A
L
H
I
T
V
ESVQPPLLNGPET
T
T
FAPCGGDELP
Q
A
A
TSYNDESSTTTGD
T
H
S
R
C
D
SIRSGSFRTNDGY
Q
R
Q
V
Y
V
V
GQSG
N
F
K
V
T
R
H
I
R
Q
CSGSSDVLAGRSS
A
A
VASSASG
T
L
T
A
T
R
LRGRQQHGSSGDTMGTG
A
V
E
V
K
R
I
S
Y
R
I
I
V
KNRCSG
E
V
L
L
T
Q
E
R
R
L
Y
T
Q
I
I
P
A
L
E
R
V
K
A
I
AGGELPA
V
P
V
K
RLPS
L
R
F
A
T
E
V
F
T
E
E
R
R
A
E
V
E
A
F
L
Q
A
V
ALS
P
F
YVR
H
P
E
V
V
K
L
LG
L
--
E
L
Y
V
TDAGAAAATGAAAAKGSRGNGADAHRPSKSPRAMHTKSSPSMGVGA
D
I
E
V
T
---PLARRGAAC
D
S
K
Y
L
S
RHSRDGEAG
V
R
A
A
AATGR-GEAG
T
G
--
C
L
T
V
D
A
L
N
A
Y
C
S
L
----
T
MGGGGGDTADSR
N
F
----CRSQS------------C
S
S
V
Q
T
S
C
S
S
V
V
-------
R
R
RK
L
D
E
V
T
M
E
D
L
E
H
I
Q
L
G
NLIGRGT
F
G
S
V
Y
L
G
L
-
V
QTQRG
S
L
M
V
A
V
K
V
MKVGEAVA
P
S
E
M
E
S
L
Q
R
E
L
D
V
L
C
A
A
R
H
K
N
I
I
R
F
L
G
SSLNT
T
T
R
D
L
R
V
F
T
E
Y
VECG
T
I
R
S
L
V
D
R
F
G
A
----
L
T
M
L
A
I
Q
Q
Y
M
Q
Q
I
L
S
G
L
Q
Y
L
H
S
L
S
-
I
A
HRDIKG
E
N
I
L
V
TKNG
R
I
K
L
SDFGSSTGA
P
C
K
V
V
A
AAESPSKGGSGGSADSAANGGLPVGSPQYM
A
P
E
V
I
H
G
--
T
V
K
S
F
----
A
-
A
V
D
IWS
L
G
C
V
G
I
E
MM--D-RPIWRESP--STN--
P
F
V
F
L
Y
R
I
S
RCGTPPHGLPT
D
D
E
L
A
A
L
KAE-----------GKKTECE
G
-
F
-
S
V
Y
----
L
-
E
F
L
R
S
C
-----
L
RVDPEQR-----P-----
S
A
A
E
L
---
L
KHPFMTYPYSKHL---R---WMPPM-PATAKPSALKSS---------------------------------------------
1
PsiBlast_PDB
63.30
33%
-50
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[27-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
Y
K
G
I
-
D
N
H
T
K
E
--
V
V
A
I
K
I
I
D
L
--
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
P
G
P
----
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
F
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
K
-----
G
E
P
P
--
N
S
D
L
H
P
M
R
V
L
F
L
I
P
K
-
N
S
P
P
------------
T
L
E
-----------
G
Q
H
S
K
-------
P
F
----
K
-
E
F
V
E
A
C
-----
L
N
K
D
P
R
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
T
-----------------------------------------------------------------------------
50
Fugue
63.21
20%
17
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
PP
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
DDA
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
-
R
A
G
G
L
F
--
Q
P
L
L
R
A
V
L
A
H
L
G
Q
----
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
----
L
Q
W
K
W
------------
L
E
A
Q
P
M
G
------------------------
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
-
M
K
A
--
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
--
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
-----
L
A
V
E
L
K
A
G
Q
T
K
T
K
G
--------------
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
--
E
E
Y
D
F
------
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A-
A
-
R
G
P
F
R
A
R
G
--
E
K
---------------------
V
E
N
K
E
L
K
Q
R
V
L
E
-----------
Q
A
V
T
Y
P
D
K
-
F
S
P
A
S
----
K
-
D
F
C
E
A
L
-----
L
Q
K
D
P
E
K
R
-----
L
GFRDG
S
C
D
G
L
---
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
---
E
A
GM
L
T
P
P
F
-
V
P
D
S
R
T
V
Y
A
K
N
G
AFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SGTC
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
VWRP
49
Fugue
61.82
22%
-2
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
GQ
C
F
S
V
E
T
L
L
D
I
L
I
C
----
L
Y
-----
D
E
C
N
N
S
P
L
----
R
R
E
K
N
------------
I
L
E
Y
L
E
W
A
K
P
F
T
-------
S
K
V
K
Q
M
R
L
H
R
E
D
---
F
E
I
L
K
V
I
G
R
G
A
F
G
--
E
V
A
V
-
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
--
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R---
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
-
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
------------------
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
--
M
E
G
G
K
GRYG
P
-
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
YG
E
-
T
P
F
Y
A
E
S
L
--
V
E
T
--
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
CSREHRLGQ
N
G
I
E
D
F
K
K
-
H
-
P
F
F
SGID
W
-
D
N
I
R
N
C
EAP
Y
I
P
E
V
S
S
P
T
D
-----
T
-----
S
N
F
D
V
DSG
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
---
V
---
L
S
D
R
S
-
C
L
R
------------------------------------------------------
3
PsiBlast_PDB
61.33
32%
-64
- C1 -
-
3GGF
1
STK26_HUMAN
A:
[31-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
A
G
P
----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
-------------------
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
K
-----
G
E
P
P
--
N
S
D
MH
P
M
R
V
L
F
L
I
-----
P
K
N
N
P
P
T
------
L
V
G
D
-----------
F
T
K
S
---------
F
----
K
-
E
F
I
D
A
C
-----
L
N
K
D
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
5
PsiBlast_PDB
60.69
31%
-56
- C1 -
-
3ZHP
-
STK24_HUMAN
C:
[35-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
7
PsiBlast_PDB
60.55
31%
-56
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[22-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
39
HHSearch
60.19
26%
-113
* C1 *
-
5K00
1
MELK_HUMAN
A:
[8-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
-
H
I
L
T
G
--
E
M
V
A
I
K
I
M
D
K
N
T
L
--
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
--
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
----
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
-
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
----
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
--
C
G
F
L
P
F
D
D
D
N
-------
V
M
A
L
Y
K
K
I
M
R
G
K
-
Y
D
--
V
---------------------------
P
K
W
L
-
S
-
P
S
S
----
I
-
L
L
L
Q
Q
M
-----
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
---
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
---
E
---
W
Q
-------------------------------------------------------------
16
PsiBlast_PDB
60.18
31%
-57
- C1 -
-
4O27
1
STK24_HUMAN
B:
[14-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
8
PsiBlast_PDB
60.16
31%
-56
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[22-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
20
PsiBlast_PDB
58.77
31%
-47
- C1 -
-
4FZA
3
STK26_HUMAN
B:
[16-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
R
A
G
P
----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
Q
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
K
-----
G
E
P
P
--
N
S
D
MH
P
M
R
V
L
F
L
I
-----
P
K
N
N
P
P
T
------
L
V
G
D
-----------
F
T
K
S
---------
F
----
K
-
E
F
I
D
A
C
-----
L
N
K
D
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
9
PsiBlast_PDB
58.34
31%
-54
- C1 -
-
4W8E
1
STK24_HUMAN
A:
[22-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
6
PsiBlast_PDB
58.23
31%
-55
- C1 -
-
3CKX
1
STK24_HUMAN
A:
[15-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
K
G
S
F
G
E
V
F
K
G
I
---
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
--
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
--
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
P
-
G
P
----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
-------------------
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
K
Q
--
S
A
Y
D
S
----
K
-
A
-
D
I
W
S
L
G
I
T
A
I
E
L
A
--
R
---------------------------
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
-----------
N
N
P
P
T
L
E
G
N
Y
-
S
K
P
----
L
K
E
F
V
E
A
C
-----
L
N
K
E
P
S
F
R
-----
P
-----
T
A
K
E
L
---
L
K
H
K
F
I
------------------------------------------------------------------------------
52
Fugue
57.60
27%
3
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
-
G
W
L
H
K
R
--
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
NDG
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
SVAQ
C
Q
L
M
K
T
ERPRPN
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
ET
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
---
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
-----------------
K
V
L
Q
N
S
R
H
P
F
L
T
A
-
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
-
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-----------------------------------
P
E
Y
L
A
P
E
V
L
E
D
--
N
D
Y
G
-----
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
--
C
-
G
R
L
-------------------------
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
-----------
E
I
R
F
P
R
T
L
-
G
-
P
E
A
----
K
-
S
L
L
S
G
L
-----
L
K
K
D
P
K
Q
R
LGGGS
E
-----
D
A
K
E
I
---
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
---
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
---------------------------------------------
27
HHSearch
57.13
32%
-89
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
-
N
V
N
T
G
--
E
L
A
A
I
K
V
I
K
L
E
P
G
---
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
--
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
P
----
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
-
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
-------------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
G
Y
N
----
Q
-
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
--
E
L
Q
P
P
M
F
D
L
H
--
P
M
R
-----
A
L
F
L
M
T
K
S
N
F
Q
P
---
P
K
---
L
K
-------------------
D
K
M
K
W
-
S
-
N
S
F
----
H
-
H
F
V
K
M
A
-----
L
T
K
N
P
K
K
R
-----
P
-----
T
A
E
K
L
---
L
Q
H
P
F
V
T
Q
----------------------------------------------------------------------------
12
PsiBlast_PDB
55.99
31%
-29
- C1 -
-
4DAW
-
PAK1_HUMAN
A:
[28-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
E
Q
S
K
R
S
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
L
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------
17
PsiBlast_PDB
55.91
31%
-29
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[32-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
E
Q
S
K
R
S
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
L
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------
13
PsiBlast_PDB
55.91
31%
-29
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[28-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
E
Q
S
K
R
S
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
L
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------
14
PsiBlast_PDB
55.73
32%
-36
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[30-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
--------------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
L
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------
19
PsiBlast_PDB
55.47
31%
-25
- C1 -
-
3Q53
1
PAK1_HUMAN
A:
[29-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
E
Q
S
K
R
S
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
I
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------
10
PsiBlast_PDB
55.26
31%
-32
- C1 -
-
3FXZ
1
?
A:
[28-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
---
E
V
A
I
R
Q
M
N
L
Q
Q
Q
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
-
T
C
----
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-----
C
A
Q
I
T
P
E
Q
S
K
R
S
--------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
R
K
A
Y
----
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
--
E
-----
G
E
P
P
YL
N
E
N
--
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
--
L
Q
N
P
E
K
L
S
A
---------------------------
I
F
----
R
-
D
F
L
N
R
C
-----
L
E
M
D
V
E
K
R
-----
G
-----
S
A
K
E
L
---
L
Q
H
Q
F
L
K
--
I
A
K
P
L
---
S
---
S
L
T
P
L
-
I
A
A
A
K
----------------------------------------------------