@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_08_0670: (2018-03-08 )
MPRHSRHSMGLTLLAAPRATPPMKAAAGVSPMKTPAAHEQEVPMHPPEGRHQPLSSRCSSSPAWLRKVKHVGTAARNVLCRLDICWAVFYFVFLVCVGSVSSSISYRLVSRSLIEAGRSLHENRITTVNKLIDQSMDRVDDMAGGLLTLYMKTQFLMQSEKTLSVLCALLERYDEARNYRAFSVISLEQLEMISCWRGSAEADAGGPLIGAISLNHTVNATYYVNRSNYMLNRPLQVSAVIPEGNGTVAALVSNYAASELIEYTQAYYKGSIDSVDIRLRWLQPSSHPHLIYYNYPAGLIYRSLKLPTNVSITDCTQVHIDGARLALNTIGEAKSGFLLAVFINQSLADADPLIMSNNWGQQTVHDNIIFPFSEHAPTAYLKSSNVSHPLMREALKHVDLSRMRDPGYKHSVDFRYNDARAVITVWAYTSCHGLTLPLVYVNSQNTVTGPYLRLHDTLNGVLAAVMVLVSLVFWLFVQLYFAAPLREITRLLNCSVQRGARALYRAGKHGIGALAEVRALGNAHNAAMRQLREVDAFVPAAVRKELPRGTLPAPLTVPIETTLAGLNVVMGSSENRAAHLARHLSTVVYITVRPPQPPPVASHSSSRTPAPLSTQPAGHDAAAITPRCKQRLSVMVQRAVHAVNATSSGPFATPAALEAFASVVHELAHTHRGTVLRLRPDTCILHFHAAVRAHLLPRQEVQLVNAADVDVVTEELAQQDARDAAAFALALLSWVDEQQTAEGQLELPRMPDVRALLDTSLFTCGQYRPADSEQTMTVALGRDVLRDAGSMVERIGVRVAMTEETAARVLRGGSGDSGAAAVSAIPVEALCTGRAEHDADELVLYEALCSRVASGTALPLYARCCFDGFARMRQGDYAGALTAFCGVAAIADLDPGLLPPCLRREVAASGATVGAVSVQVARLMRECERCVRAGVADGFQRVPRRPPGMDAVLPDDITPLGTAPPVSTARSGVPAASAKPRRMASSFTAPPWYPEVGDRHVMLLSNGAVTTRVVVPTPPAWVRDNHGMYWQLACRKSDCTPPELWACRILALGSAGAIASVNYIMYREVHPVVAKAIRDAPPGPISDALRRATPVCGPTAQQDASIKRLITRHQELRHPNILAPLAYSQSVEGGVVLIWEFCPGGTLRQLLARYPRVKSVTFACFGLQMLSALSHLHERGVAHGRLNLDNVMVDSNGHCRLIGQFADHALEREIFHFKPSCYLSPAMAAGALPTPPCDMFCYGLLAMEAVTQQPCWRWATAAEYGGHRDSKPPSAKELADLMATGGQRFADAVVQGRVVLNLEQLDVGPITEHHNDTMISVCRRLLSLDPASRPTAAELREENKSVLNLLGITMEEDTR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070--.......1080......1090-......--1100..-----....1110...-...1120--------..---....1130......1140......1150.--.----------------.---...1160......1170......-1180......1190....-..1200......1210-------.---------.....1220----.----........--1230......1240......1250------.-........1260......1270......1280.-------.....-------1290......1300.---------...---------..1310......1320......1330......1340......1350......---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPRHSRHSM
G
L
T
L
L
AAPRATPPMKAAAGVSPMKTPAAHEQEVPMHPPEGRHQ
P
L
S
S
RCSSS
P
A
W
L
R
K
V
K
H
V
G
T
A
A
R
N
V
L
C
R
L
D
I
C
W
A
V
F
Y
F
V
F
L
V
C
V
G
S
V
S
S
S
I
S
Y
R
L
V
S
R
S
L
I
E
A
G
R
S
L
HE
N
R
I
T
T
V
N
K
L
I
D
Q
S
M
D
R
V
D
D
MA
G
G
L
L
T
L
Y
M
K
T
Q
F
L
MQSE
K
T
L
S
V
L
C
A
L
L
E
R
Y
D
E
ARN
Y
R
A
F
S
V
I
S
L
E
Q
L
E
M
I
S
CWRGSAEADAGG
P
L
I
G
A
I
S
LN
H
T
V
N
A
T
Y
Y
V
NRSN
Y
M
LNR
P
L
Q
V
S
A
V
IPEGNG
T
V
A
A
L
V
S
N
Y
A
A
S
E
L
I
E
Y
T
Q
A
Y
YKGSI
D
S
V
D
I
R
L
R
W
LQPSSHP
H
L
I
Y
Y
NY
P
A
G
L
I
Y
R
SLKLPTNVSI
T
D
C
T
Q
V
H
IDG
A
R
L
A
L
N
T
IGEAKS
G
F
L
L
A
V
F
INQSLADAD
P
L
I
MSNNWGQQTVHD
N
I
I
F
PFSEHAP
T
A
Y
LKSSNVS
H
P
L
M
R
E
A
L
K
HV
D
L
S
RMRDPGYK
H
S
V
D
F
R
YND
A
R
A
V
I
T
V
W
A
YTSCH
G
L
T
L
P
L
V
Y
VNSQNTVTG
P
Y
L
R
L
H
D
T
L
N
G
V
L
A
A
V
M
V
L
V
S
L
V
F
W
L
F
V
Q
L
Y
FAA
P
L
R
E
I
T
R
L
LNC
S
V
Q
R
G
A
R
A
L
Y
R
AGKH
G
I
G
A
L
A
E
V
R
A
LGN
A
H
N
A
A
M
R
Q
L
R
E
V
D
A
F
V
P
A
A
V
R
K
ELPRGTLPA
P
L
T
V
P
I
E
T
TLA
G
L
N
V
VMGSSE
N
R
A
A
H
L
A
R
H
L
S
T
V
V
Y
I
T
VRPPQPPPVASHSSSRTPAPLSTQPAGHDAAAI
T
P
R
C
K
Q
R
L
S
V
M
V
Q
R
A
V
H
A
VNATSSGPFA
T
P
A
A
L
E
A
F
A
S
V
V
H
E
L
A
HTHRG
T
V
L
R
LRPD
T
C
I
L
H
F
H
A
A
V
R
A
H
LL
P
R
Q
E
V
Q
L
VNAA
D
V
D
V
V
T
E
E
L
A
Q
Q
D
A
R
D
A
A
A
F
A
L
A
L
L
S
W
V
D
E
Q
QTAEGQLELPRMP
D
V
R
A
L
L
D
T
S
L
FTCGQYRPADSE
Q
T
M
T
V
A
L
G
R
D
V
L
R
D
A
G
S
M
V
E
R
IG
V
R
V
A
M
T
E
E
T
A
A
R
V
LRGGSGDSG
A
A
A
V
SAI
P
V
E
A
LCTGRAEH
D
A
D
E
L
V
L
Y
E
A
L
C
S
R
VASGTA
L
P
L
Y
A
R
C
C
F
D
G
F
A
R
MRQGDY
A
G
A
L
T
A
F
C
G
V
A
A
I
ADLDPGLL
P
P
C
L
R
R
E
V
AASGA
T
V
G
A
V
S
V
Q
V
A
R
L
M
R
E
C
E
R
C
V
R
A
G
V
A
D
G
F
Q
RVPRRPPGMDAVLPDDITPLGTAPPVSTARSGVPAASAK
P
R
R
M
A
SSFTAPPWYPEVG
D
R
H
V
M
L
LSNG
A
V
T
T
R
V
V
VPTPPAWVRDNH
G
M
Y
W
Q
L
A
C
RKSDCT
P
P
E
L
W
A
C
R
I
L
A
LGSAG
A
I
A
S
V
N
Y
I
M
YR
E
V
H
P
V
---
V
A
K
A
I
RDAPPG
P
I
S
D
A
L
R
RAT-PVCGPT--AQ
Q
D
A
S
-----
I
K
R
L
I
T
R
H
Q
EL-RHPN
I
L
A--------PL---AYSQSVEG
G
V
V
L
I
W
EFCPG
G
T
L
R
Q
L
L
A
RY--P----------------R---VK
S
V
T
F
A
C
F
G
L
Q
M
L
S
A
L
S
H
L
H
E
R-GVAHGRLN
L
D
N
V
M
VDSNG-
H
C
R
L
I
G
Q
F
A
D
H
A
L
E
R
E
-------
I
---------FHFKPS-------C----YLSP
A
M
AA--GALPTP
P
C
D
M
F
C
Y
G
L
L
A
M
E
A
V
---------
T
-QQPCW
R
W
A
T
A
A
EYGGHRDSKPP
S
A
K
E
L
A
D
L
M
A
T-------G
G
Q
R
F
-------
A
D
A
V
VQG
R
V
V
L
N
L
EQ---------LDV---------GPITEHHN
D
T
M
I
S
V
C
R
R
L
LSLDPASR
P
T
A
A
E
L
R
E
E
N
K
S
V
L
N
L
LGITMEEDTR---------------------
21
HHSearch
74.39
18%
-106
- C2 -
-
4G3F
1
A:
[63-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
--
T
G
F
Q
C
---
A
V
K
K
V
R
L
E
--------------------------
V
F
-----
R
V
E
E
L
V
A
C
A
G
L
-
S
S
P
R
I
V
P
--------
L
Y
---
G
A
V
R
E
-
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
--
G
----------------
C
---
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
----------
D
---------
Y
I
P
G
T
E
-------
T
----
H
M
A
P
E
V
V
M
--
G
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
---------
N
-
G
C
H
P
W
T
Q
Y
F
R
G
--------------
P
L
C
L
K
-------------------------
I
A
S
E
P
P
P
----------------
I
---------
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
----------------------------
48
Fugue
66.51
14%
-43
- C2 -
-
4BTF
2
MLKL_MOUSE
A:
[7-460]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
L
G
Q
I
I
K
--
L
G
Q
L
I
Y
E
Q
C
E
K
M
K
Y
C
R
K
Q
C
Q
R
L
G
N
R
V
H
G
L
L
Q
P
L
Q
R
L
Q
A
Q
G
K
K
N
L
P
D
D
I
T
A
A
L
G
R
F
D
E
V
L
K
E
A
N
Q
Q
I
E
K
F
I
L
F
H
E
V
N
E
K
L
R
D
V
W
E
E
L
L
L
L
L
Q
V
P
A
S
W
Q
Q
E
D
R
Q
D
A
E
E
D
G
N
E
N
M
K
V
I
L
M
Q
L
Q
I
S
V
E
E
I
N
K
T
L
K
Q
C
S
I
P
Q
D
L
Q
I
K
E
I
P
K
E
H
L
G
P
P
W
T
K
L
K
T
S
K
M
S
T
I
Y
R
G
E
Y
H
R
---
S
P
V
T
I
K
V
F
N
N
P
Q
A
E
S
------------
V
--
G
I
V
R
F
T
-----
F
N
D
E
I
K
T
M
K
K
F
-
D
S
P
N
I
L
R
--------
I
F
G
I
C
I
D
Q
T
V
K
P
P
E
F
S
I
V
M
E
Y
C
E
L
G
T
L
R
E
L
L
D
R
E
--
K
----------------
D
---
L
T
M
S
V
R
S
L
L
V
L
R
A
A
R
G
L
Y
R
L
H
H
S
-
E
T
L
H
R
N
I
S
S
S
S
F
L
V
A
G
G
Y
-
Q
V
K
L
A
G
F
E
L
S
K
T
Q
N
S
I
-------
S
---------
R
T
A
S
S
T
-------
I
----
Y
V
S
P
E
R
L
K
N
P
F
C
L
Y
D
I
K
A
E
I
Y
S
F
G
I
V
L
W
E
I
A
---------
T
-
G
K
I
P
F
--------------
E
G
C
D
S
K
K
I
R
E
L
V
A
E
-------
D
K
K
Q
--------------------------------------------
E
P
V
G
Q
D
C
P
E
L
L
R
E
I
I
N
E
C
R
A
H
E
P
S
Q
R
P
S
V
D
G
I
L
E
R
L
S
A
-----------------------------------
10
PsiBlast_PDB
65.66
28%
-146
- C2 -
-
5EYK
1
AUKBA_XENLA
A:
[58-207]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
--------------------
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
65.37
21%
-24
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
A
Q
-------
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
---
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
-
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
V
L
Q
N
S
-
R
H
P
-
F
L
T
--------
A
L
---
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
----------------
V
---
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
-
H
I
K
I
----
T
D
F
G
L
C
P
E
-----------------------------------
Y
L
A
P
E
V
L
E
--
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
GRLPFYNQ
D
-
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
DPKQRLG
G
G
S
E
D
-------
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
---------
Q
H
V
Y
E
KKLSPPF
K
P
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------------------
9
PsiBlast_PDB
61.74
28%
-138
- C2 -
-
2VRX
1
AUKBA_XENLA
A:
[62-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.43
28%
-143
- C2 -
-
4C2V
1
AUKBA_XENLA
A:
[63-212]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.35
28%
-139
- C2 -
-
2BFX
-
AUKBA_XENLA
A:
[138-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.29
28%
-140
- C2 -
-
4C2W
1
AUKBA_XENLA
A:
[61-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.24
28%
-138
- C2 -
-
2VGO
1
AUKBA_XENLA
A:
[61-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.07
28%
-139
- C2 -
-
4B8M
1
AUKBA_XENLA
A:
[62-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.71
28%
-139
- C2 -
-
3ZTX
1
AUKBA_XENLA
A:
[61-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.35
28%
-140
- C2 -
-
2VGP
1
AUKBA_XENLA
A:
[61-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.27
28%
-138
- C2 -
-
2BFY
1
AUKBA_XENLA
A:
[61-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
G
-
W
S
V
H
A
P
-------
S
---------
L
R
R
R
T
M
-------
C
GTLD
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
59.11
19%
-89
- C2 -
-
4IDV
1
M3K14_HUMAN
A:
[80-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
--
T
G
F
Q
C
---
A
V
K
K
V
R
L
E
--------------------------
V
F
-----
R
A
E
E
L
M
A
C
A
G
L
-
T
S
P
R
I
V
P
--------
L
Y
---
G
A
V
R
E
-
G
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
--
G
----------------
C
---
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
-------
G
LGKSLLTGD
Y
I
P
G
T
E
-------
T
----
H
M
A
P
E
V
V
L
--
G
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
---------
N
-
G
C
H
P
W
T
Q
F
F
R
G
--------------
P
L
C
L
K
-------------------------
I
A
S
E
P
P
P
----------------
V
---------
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
----------------------------
39
HHSearch
58.57
17%
-36
- C2 -
-
4CKJ
14
A:
[71-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
-----
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
--------
L
Y
---
G
A
C
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--
R
----------------
K
VRA
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
-
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
-
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
DSYVKR-
S
---------
Q
G
R
I
P
V
-------
K
----
W
M
A
I
E
S
L
F
--
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
---------
T
L
G
G
N
P
Y
P
G
I
P
P
E
--------------
R
L
F
N
L
L
-------------------------
K
T
G
H
-
R
--------------------------
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
-------------------------------
7
PsiBlast_PDB
58.46
28%
-136
- C2 -
-
4B8L
1
AUKBA_XENLA
A:
[62-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
R
E
I
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
--------
M
Y
---
N
Y
F
H
D
-
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--
G
----------------
R
---
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
M
G
Y
K
G
-
E
L
K
-
I
A
D
F
---------------------------------------TLD-
Y
L
P
P
E
M
I
E
--
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
---------
V
-
G
M
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
57.16
17%
-75
- C2 -
-
4YJR
1
A:
[61-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-----
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
--------
M
I
---
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
--
R
----------------
H
---
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
-
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
-
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
ENYYKAQ
T
---------
H
G
K
W
P
V
-------
K
----
W
Y
A
P
E
C
I
N
--
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
---------
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
--------------
E
V
T
A
M
L
E
-------------------------
K
G
E
R
---------------------------
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
-------------------------------
38
HHSearch
55.95
18%
-43
- C2 -
-
3TT0
1
FGFR1_HUMAN
A:
[119-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
-----
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
--------
L
L
---
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
--
R
PPGLEYSYNPSHNP
E
E
Q
---
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
-
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
-
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
YYKKT-
T
---------
N
G
R
L
P
V
-------
K
----
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
---------
T
L
G
G
S
P
Y
P
G
V
P
V
E
--------------
E
L
F
K
L
L
K
E
-------------------------
G
H
R
---------------------------
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
----------------------------
27
HHSearch
52.85
19%
-37
- C2 -
-
2PSQ
-
B:
[131-366]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
-----
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
--------
L
L
---
G
A
C
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
--
R
PPGEE-----------
Q
---
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
-
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
-
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
DYYKKT-
T
---------
N
G
R
L
P
V
-------
K
----
W
M
A
P
E
A
L
F
--
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
---------
T
L
G
G
S
P
Y
P
G
I
P
V
E
--------------
E
L
F
K
L
L
K
E
-------------------------
G
H
R
---------------------------
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
------------------------------
51
Fugue
51.98
13%
-23
- C2 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
--
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
--
K
L
E
K
K
R
-----
I
K
K
R
K
G
E
A
M
A
L
-
N
E
K
Q
I
L
E
K
VNSRFVV
S
L
---
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
GQ
A
----------------
G
---
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
-
H
I
R
I
----
S
D
L
G
L
A
V
H
-------
V
---------
P
E
G
Q
T
I
K
G
RVGTV
G
----
Y
M
A
P
E
V
V
K
--
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
---------
A
-
G
Q
S
P
F
Q
----------
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
-------
V
P
E
E
Y
S
ERFS
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
RLGCRGGS
A
R
E
V
---------
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS