@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_11_0110: (2018-03-08 )
MGGELDDQNKDAPDDGNAARKRACLEHVLPSMQQRFAELAHASVGESSLTVEALFQRYQRVLKVGEGTFGEVFVLYDTVAHTYITMKRMHTLLSLRRRSLGIHRCTFREVELLAALQHPNIVQVLDYHILSDGSLVMLMPVIAHDLTSLLRRWPATPQSSGHGTASTAASMRPRMPLHVVKCIFRQIIAGIAYLHKHKVVHRDLKPSNVMVDHTGVVKLIDFGWSRFCAAAGAMTGPPCVTAFRPPEVLVGAHNHYTFSLDIWCCGCILFEMLTGGTPFAKSRNEAECLANIVDWLGSPPSSSEVYYRCAARCTFPLAPGRPDTFAQRCNNYGIKSAEAMFLRRMLCLEPGERATAEALLRDPWFTTAPTMCVPRAIPLPAHNMFRLVEVKRKELEH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220....-...230-.......240.......250.......260.......270.......280.......290.......-----300--.--......310.....-...320--.......330--.......340.......350.......360.......370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGGELDDQNKDAPDD
G
N
A
A
R
K
R
A
C
L
E
H
V
L
P
S
M
Q
Q
R
F
A
E
L
A
H
ASVGESS
L
T
V
E
A
L
F
Q
R
Y
Q
R
V
L
K
VGEGTF
G
E
V
F
V
L
YDT
V
A
H
T
Y
I
T
M
K
R
M
H
T
L
L
S
L
R
R
R
SLGIHR
C
T
F
R
E
V
E
L
L
A
A
LQHPN
I
V
Q
V
L
D
Y
HILSDG
S
L
V
M
L
M
P
V
I
A
H
D
L
T
S
L
L
R
RWPATPQSSGHGTAS
T
A
ASMRPRM
P
L
H
V
V
K
C
I
F
R
Q
I
I
A
G
I
A
Y
L
H
K
H
K
V
V
HRDLKPS
N
V
M
VDHTGV
V
K
L
I
DFG
W
S
R
-
F
C
A
AAG-AMTGPPCVTAFR
P
P
E
V
L
V
G
AHN
H
Y
T
F
S
L
D
I
W
C
C
G
C
I
L
F
E
M
LTGGTPFAKSR
N
E
A
E
C
L
A
N
I
V
D
W
LGSP-----PSS--S--
E
V
Y
Y
R
C
A
-
A
R
C
TFP-LAPGRP--
D
T
F
A
Q
R
C
NNY--GIK
S
A
E
A
M
F
L
R
R
M
L
CLEPGE
R
A
T
A
E
A
L
L
RDPWFTTAPTMCVPRAIPLP
A
H
N
M
F
R
L
V
E
V
K
R
K
ELEH
5
PsiBlast_PDB
86.61
30%
-115
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[2-284]
-------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
T
F
A
L
K
K
-----
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
-
I
H
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-------
D
V
C
E
G
G
L
E
S
V
T
A
-----------
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
-
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
-----
N
S
K
--
N
WP
N
V
T
E
L
P
K
-
Y
D
P
N
F
T
-
V
Y
E
P
L
P
W
-
E
S
F
L
K
G
L
D
E
S
--
G
I
D
-----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------
8
PsiBlast_PDB
85.27
29%
-97
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[7-293]
-------------------------------------------------------
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
----
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
-
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
P
-----
G
Q
Y
M
D
S
S
-----------
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
-
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
-
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
-----
N
N
E
VW
P
--
E
V
E
S
L
Q
D
-
Y
K
N
T
F
P
---
K
W
K
P
--
G
S
L
A
S
H
V
K
N
L
--
D
E
N
G
L
D
--
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
-------------------------------
7
PsiBlast_PDB
85.27
29%
-97
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[7-293]
-------------------------------------------------------
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
----
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
-
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
P
-----
G
Q
Y
M
D
S
S
-----------
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
-
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
-
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
-----
N
N
E
VW
P
--
E
V
E
S
L
Q
D
-
Y
K
N
T
F
P
---
K
W
K
P
--
G
S
L
A
S
H
V
K
N
L
--
D
E
N
G
L
D
--
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
-------------------------------
9
PsiBlast_PDB
84.21
29%
-102
- C1 -
-
5LQF
1
CDK1_HUMAN
A:
[7-293]
-------------------------------------------------------
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
----
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
-
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
P
-----
G
Q
Y
M
D
S
S
-----------
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
------
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
-
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
-----
N
N
E
VW
P
--
E
V
E
S
L
Q
D
-
Y
K
N
T
F
P
---
K
W
K
P
--
G
S
L
A
S
H
V
K
N
L
--
D
E
N
G
L
D
--
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
-------------------------------
10
PsiBlast_PDB
81.68
29%
-92
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[7-293]
-------------------------------------------------------
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
----
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
-
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
P
-----
G
Q
Y
M
D
S
S
-----------
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
-
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
-
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
-----
N
N
E
VW
P
--
E
V
E
S
L
Q
D
-
Y
K
N
T
F
P
---
K
W
K
P
--
G
S
L
A
S
H
V
K
N
L
--
D
E
N
G
L
D
--
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
-------------------------------
15
PsiBlast_PDB
81.10
29%
-108
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
2
PsiBlast_PDB
81.02
30%
-107
- C1 -
-
3NIZ
1
?
A:
[15-304]
-------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
I
-
V
A
L
K
R
I
R
----------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
-
I
H
S
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
K
T
G
L
Q
D
S
Q
------------------
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
-
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
NPREW
P
Q
V
--
Q
--
E
L
--
P
L
W
-
K
Q
R
T
F
Q
-
V
F
E
K
K
P
W
S
S
I
I
P
G
F
C
Q
E
---
G
I
D
-----
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
--------------------------------
18
PsiBlast_PDB
80.49
29%
-109
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
14
PsiBlast_PDB
80.30
29%
-113
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
3
PsiBlast_PDB
79.96
30%
-95
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-284]
--------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
E
T
F
A
L
K
K
-----
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
-
I
H
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-------
D
V
C
E
G
G
L
E
S
V
T
A
-----------
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
-
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
-----
N
S
K
--
N
WP
N
V
T
E
L
P
K
-
Y
D
P
N
F
T
-
V
Y
E
P
L
P
W-
E
S
F
L
K
G
L
D
E
S
--
G
I
D
-----
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------
12
PsiBlast_PDB
78.94
29%
-109
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
13
PsiBlast_PDB
78.21
29%
-108
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
17
PsiBlast_PDB
77.04
29%
-105
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
11
PsiBlast_PDB
76.83
29%
-107
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
16
PsiBlast_PDB
75.14
29%
-108
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[7-291]
-------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-----------------
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
-
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
--
P
-
G
V
T
S
M
P
D
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
6
PsiBlast_PDB
74.84
29%
-126
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-294]
------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----------------
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
S
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
P
G
V
-
T
S
M
P
-
D
-
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
VP
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
1
PsiBlast_PDB
74.64
30%
-114
- C1 -
-
2QKR
-
?
A:
[15-304]
-------------------------------------------------
Y
F
Q
G
L
M
E
K
Y
--
L
E
K
V
G
E
G
---
V
V
Y
K
A
K
D
S
Q
-
R
I
-
V
A
L
K
R
I
--------------
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
-
I
H
S
E
-
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
K
T
G
L
Q
D
S
Q
------------------
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
-
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
-
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
NPREW
P
Q
V
--
Q
--
E
L
--
P
L
W
-
K
Q
R
T
F
Q
-
V
F
E
K
K
P
WS
S
I
I
P
G
F
C
Q
E
---
G
I
D
-----
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
--------------------------------
20
PsiBlast_PDB
73.64
29%
-108
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[8-294]
-----------------------------------------------------
F
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
-
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----------------
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------
D
--
E
V
V
W
P
G
V
-
T
S
M
P
-
D
-
Y
K
P
S
F
P
--
K
W
A
R
Q
D
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------
40
HHSearch
68.13
27%
-95
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-300]
----------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
-------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
K
-
S
N
I
S
L
V
F
D
F
M
E
T
D
---
L
E
V
I
I
K
---------------
D
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
G
V
L
K
L
A
D
F
G
L
A
K
-
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
-
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
-
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
-----
T
E
E
--
Q
--
W
P
D
M
C
S
L
P
D
Y
V
T
F
K
-
S
F
P
G
I
P
--
L
---
H
-
H
I
F
S
--
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
G
---------------------------
19
PsiBlast_PDB
66.50
29%
-
- C- -
-
4YC6
-
CDK1_HUMAN
A:
[2-288]
-------------------------------------------------------
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
----
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
I
V
S
L
Q
D
V
-
L
M
Q
D
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
P
P
-----
G
Q
Y
M
D
S
S
-----------
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
-----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
-
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
-----
N
N
E
VW
P
--
E
V
E
S
L
Q
D
-
Y
K
N
T
F
P
---
K
W
K
P
--
G
S
L
A
S
H
V
K
N
L
--
D
E
N
G
L
D
--
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
-------------------------------