@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_13_0280: (2018-03-08 )
MLVTMENYQIIESIGEGSFGKVYKARIKGTGQIVAMKFIVKKGKNEKELKNLRSEIEILTKLNHPHIIMLFDSFETDSDFVVVMEYAQGELYDILEDEKQLPAKEVQKIAKQLIQALNYLHSNRIIHRDMKPQNILIGQNGAVKLADFGFARSMSYNTIVLTSIKGTPLYMAPELVQERAYDNRVDLWSLGCILYELYYGKPPFYTNNLFALIKKIVCEPVKYDSKANDPISPEFKSFLSGLLTKSASSRLNWPELLNHPFVQLTKSDASWQDAIMQHDSRMKARMDRLGCLRLHGNAGRAAPKRKSTQSDDIFNLKTVQKLTSGCEFDVCATLTQLVRMARASNGDVTKSTALLGVFDSGVLEAALTLLNEKQSVKVVGLVLQFVQELVFPEHGDLLAFPSQRPKRDGLAVLEEKHSRQQEDLFIRQQVALKLMKKPHTALDFIISEISSGGDSLAETCVKIMFQCFRWENSFGPMVTQLRTFPEMWAAILKSVNHHSVSRGETSHEYAALVFHTVSIVIPHVKLASPQRINREEVLELVTQGLSAVCYYEAGMVDAHRNKTPPLVYAAAAALLIAFAHRELKDIVSFKVNGALLDGIYSIVDAVTDAPSRPVTPRALGSSYGYPDYGLLDGVAHMLSLVFSDSDSLVYAKLPGRSEHRFLESDTKSLALLVMTLLRDSDPRMELSPNGVQTLLRAAQQIFQQEKEQALSMSLLMEPIAPYSGESGSLCWLSVICRTMKTDYFRQLFYWPACRGGGATGVSAHVTIVSQILSDSLRPVSSSSNPTPVEDKLLGDVSRVLYKEKVIELLVHAMDYSEGVFLGSPFAIIAKLCANSADSIKAFVDCGGVDAARIRRILDPDKAGTGLMSDGLVVLSQMARMSAEFYEPIHRSNLYDCLAALLQHSEKDLRGKTCTLIGNLCKHSDFFFEPLEKNHIVERLVKCCSDSDAQTQKLAAFAIGNAAFHSGYLYNLLSPAIPSLVGLLACGDAKTRQNAAGALSNFVRNGDQLVSSLAESSVVESLLKMLRDDDTPSSKKVAVLTINSFCAYDVFRRKFIALNLREDIRKLQQDPNARADPSIQKYVGNLVDRLG
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40...-------.------..-..50-........60.-.-......70........80....-...-.-90..--....--..100.......110.......120..-.....130.....---.---.140-..---.......150.......160...-....170....-----.------..180---.........190.......200.......210....-------...220..-.....230------........240.......250----........260.------......270.....--------..280........290....---...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
V
TM
E
N
Y
Q
I
I
E
S
IGEGSFG
K
V
Y
K
A
R
IKGT
G
Q
I
V
A
M
K
F
I
V
KKGK-------
N
------
E
K
-
E
L
K
N
-
L
R
S
E
I
E
I
L
T
KL-N-HP
H
I
I
M
L
F
DSFETDS
D
F
V
V
V
M
E-YAQ-
G
-
E
L
Y
D
--
I
L
E
D
--
E
KQL
P
A
K
E
V
Q
K
I
A
K
Q
L
I
Q
A
L
N
Y
L
H
SN
R
-
I
I
HRDMKPQ
N
I
L
I---G---QN---G
A
---
V
K
L
ADFGFARSMSY
N
T
I
V
L
T
SIK-GTPLYM
A
P
E
L
V
-----
Q
------
E
R
A-----YDNRV
D
L
W
S
L
G
C
I
L
Y
E
L
YYGKPPFYTN
N
L
F
A
L
I
K
K
I-------VCEPVKYD-SKANDPI-------
S
P
E
F
K
S
F
L
S
G
L
L
T
KSASSRL-----N
W
P
E
L
LNHP
F
V
Q
------LTKSDA
S
W
Q
D
A
I
M
Q
--------
H
D
S
R
-
M
K
A
R
M
D
R
L
G
C
L
R
L
HG---NAGRAAPKRKSTQSDDI
F
N
L
K
T
V
Q
K
L
T
SGCE
F
D
V
C
A
T
L
T
Q
L
V
R
M
A
RASNGDVTKS
T
A
L
L
G
V
F
D
S
G
V
L
E
A
A
L
T
L
LNEK
Q
S
V
K
V
V
G
L
V
L
Q
F
V
Q
E
LVFPEHGDLLAFPSQRPKRD
G
L
A
V
L
E
E
K
HS
R
Q
Q
E
D
L
F
I
R
Q
Q
V
A
L
K
L
MKKP
H
T
A
L
D
F
I
I
S
E
I
SSG
G
D
S
L
A
E
T
C
V
K
I
M
F
Q
C
F
R
WENSF
G
P
M
V
T
Q
L
R
T
F
P
E
M
W
A
A
I
L
K
S
V
N
HHSVSRGETS
H
E
Y
A
A
L
V
F
H
T
V
S
I
V
IPHVKLASPQRI
N
R
E
E
V
L
E
L
V
T
Q
G
L
S
A
V
C
Y
YEAGMVDAHRNKTP
P
L
V
Y
A
A
A
A
A
L
L
I
A
F
A
H
R
E
L
K
D
I
V
S
FKV
N
G
A
L
L
D
G
I
Y
S
I
V
D
A
VTDAPSRPVT
P
R
ALGSSYGYPD
Y
G
L
L
D
G
V
A
H
M
L
S
L
V
FSDSD
S
L
V
Y
A
KLPGRSEH
R
F
L
E
S
D
T
K
S
L
A
L
L
V
M
T
L
LRDSDPRMELSP
N
G
V
Q
T
L
L
R
A
A
Q
Q
I
F
Q
Q
E
K
E
Q
A
L
S
M
S
L
L
MEPIAPYSGESGS
L
C
W
L
S
V
I
C
R
T
M
K
T
D
Y
F
R
Q
L
FYWPACRGGGATG
V
S
A
H
V
T
I
V
S
Q
I
L
S
D
SLRPVSSSSNPTP
V
E
D
K
L
L
G
D
V
S
R
V
L
Y
K
E
K
V
I
E
L
L
V
H
A
MDYSEGVFLG
S
P
F
A
I
I
A
K
L
CANS
A
D
S
I
K
A
F
V
DCGGV
D
A
A
R
I
R
R
I
LDPDKAGTGLMS
D
G
L
V
V
L
S
Q
M
A
R
M
S
A
E
F
Y
E
P
I
H
RS
N
L
Y
D
C
L
A
A
L
L
QHS
E
K
DLRG
K
T
C
T
L
I
G
N
L
C
KHSD
F
F
FEPLEK
N
H
I
V
E
R
L
V
K
CCSDSDA
Q
T
Q
K
L
A
A
F
AIGN
A
A
FHS
G
Y
L
Y
N
L
L
S
P
A
I
P
S
L
V
G
L
LACGDAKTR
Q
N
A
A
G
A
L
S
N
F
V
R
N
G
D
Q
L
V
S
S
L
A
E
S
S
V
V
E
S
L
L
K
M
L
RDDDTPSS
K
K
V
A
V
L
T
IN
S
F
C
A
Y
D
V
F
R
R
K
F
I
A
L
N
L
R
E
D
I
R
K
L
QQDPNARADP
S
I
Q
K
Y
V
G
N
L
V
D
RLG
50
Fugue
69.36
24%
44
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
-------
K
------
K
R
K
G
E
A
M
-
A
L
N
E
K
Q
I
L
E
K
V
-
N
-
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
-
L
M
N
-
G
G
D
L
K
F
--
H
I
Y
H
MG
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
---
D
H
---
G
H
---
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
-
T
I
K
G
R
V
-
G
T
V
G
Y
M
A
P
E
V
V
-----
K
------
N
E
R
-----
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
-------
E
R
L
V
K
E
V
P
-
E
E
Y
S
E
R
F
-------
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
GCRGG
S
A
R
E
V
K
E
H
P
L
F
K
----------
K
L
N
F
K
R
L
G
A
G
MLEPPFKP
D
P
Q
A
-
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
---
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.28
35%
-9
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
G
G
GSFS
A
E
E
V
------
Q
E
-
L
R
E
A
-
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
-
L
M
K
K
G
-
E
L
F
D
--
Y
L
T
E
--
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
D
---
M
N
---
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
-----
E
C
S
M
N
DN
H
P
G
-----
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
R
M
I
-------
M
S
G
N
Y
Q
F
G
-
S
P
E
W
D
D
Y
-------
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
P
F
F
Q
------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
62.93
34%
9
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
--------------------------------------------------------------------IV
K
E
G
W
L
H
K
R
GEYIT
W
R
P
R
Y
F
L
L
K
NDG
T
F
I
G
Y
KERPAPLNNFSVAQ
C
Q
L
M
K
T
ERPRPN
T
F
I
I
R
C
LQWT
T
V
I
E
R
T
F
H
V
ET
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
V
L
Q
-------
N
------
S
R
--------------------
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
-
Y
A
N
-
G
G
E
L
F
F
--
H
L
S
R
--
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
---
K
D
---
G
H
---
I
K
I
T
D
F
G
L
C
-----------------
P
E
Y
L
A
P
E
V
L
-----
E
------
D
N
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
-------
L
M
E
E
I
R
F
P
-
R
----
T
L
-------
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGSE
D
A
K
E
I
M
Q
H
R
F
F
----------
A
G
I
V
W
Q
H
V
Y
E
K
--------
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
61.97
33%
-53
- C1 -
-
5IG1
-
?
A:
[15-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
D
L
K
D
K
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
-------
R
------
S
S
-
E
I
N
K
-
I
K
R
E
I
G
I
C
S
S
L
-
Q
-
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
-
Y
V
S
G
G
-
E
L
F
D
--
E
I
V
T
--
R
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
-
I
I
H
R
D
L
K
P
E
N
L
L
L
---
A
SKD
P
N
---
A
P
---
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
P
-
T
Y
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
I
-----
R
------
R
V
P
-----
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
Q
K
L
Y
A
Q
I
-------
K
N
C
Q
Y
D
F
P
-
S
P
E
W
D
S
V
-------
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
-----
T
V
Q
E
L
L
Q
H
P
W
I
A
------
R
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
61.14
27%
10
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
------------------------------------------------------------------------------------------S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
SPLRRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
-------
L
------
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
-
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
-
Y
Y
V
G
G
-
D
L
L
T
--
L
L
S
K
F
-
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
-
Y
V
H
R
D
I
K
P
D
N
I
L
M
---
D
---
M
N
---
G
H
---
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
-----
Q
------
A
M
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
-------
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
D
V
-------
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
GQN--
G
I
E
D
F
K
K
H
P
F
F
S
GIDWDN
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
--------
P
T
D
T
-
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
60.55
32%
-49
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[4-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
-------
S
------
A
R
-
D
F
Q
K
-
L
E
R
E
A
R
I
C
R
K
L
-
Q
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
-
L
V
T
G
G
-
E
L
F
E
--
D
I
V
A
--
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
-
I
V
H
R
N
L
K
P
E
N
L
L
L
---
A
---
S
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
N
D
S
-
E
A
W
H
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
D
P
-----
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
A
Q
I
-------
K
A
G
A
Y
D
Y
P
-
S
P
E
W
D
T
V
-------
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
------
N
R
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.57
35%
-42
- C1 -
-
3MWU
1
?
A:
[22-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
G
-
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
---
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
----
D
R
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
59.16
33%
-48
- C1 -
-
5IG1
-
?
B:
[15-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
D
L
K
D
K
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
-------
R
------
S
S
-
E
I
N
K
-
I
K
R
E
I
G
I
C
S
S
L
-
Q
-
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
-
Y
V
S
G
G
-
E
L
F
D
--
E
I
V
T
--
R
K
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
-
I
I
H
R
D
L
K
P
E
N
L
L
L
---
A
SKD
P
N
---
A
P
---
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
G
P
-
T
Y
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
I
-----
R
------
R
V
P
-----
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
Q
K
L
Y
A
Q
I
-------
K
N
C
Q
Y
D
F
P
-
S
P
E
W
D
S
V
-------
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
-----
T
V
Q
E
L
L
Q
H
P
W
I
A
------
R
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.08
35%
-37
- C1 -
-
4Y5Q
1
?
A:
[22-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
G
-
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
---
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---
D
R
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.90
35%
-44
- C1 -
-
2WEI
1
?
A:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
G
-
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
---
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
M
K
D
R
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
58.84
35%
-4
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[94-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
----------
R
LSPEQL
E
E
-
V
R
E
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
-
L
M
R
K
G
-
E
L
F
D
--
Y
L
T
E
--
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
N
---
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
P
G
-----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
-------
M
E
G
Q
Y
Q
F
S
-
S
P
E
W
D
D
R
-------
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
58.21
31%
-46
* C1 *
-
2VN9
1
KCC2D_HUMAN
B:
[3-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-------
S
------
A
R
-
D
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
-
L
V
T
G
G
-
E
L
F
E
--
D
I
V
A
--
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
-
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
---
S
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
D
P
-----
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
-------
K
A
G
A
Y
D
F
P
-
S
P
E
W
D
T
V
-------
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
------
Q
R
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.14
34%
-32
- C1 -
-
5AJQ
2
STK10_HUMAN
A:
[16-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
----------------
E
E
-
E
L
E
D
-
Y
I
V
E
I
E
I
L
A
T
C
-
D
-
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
-
F
C
P
-
G
-
G
A
V
D
A
I
M
L
E
L
--
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
---
L
E
---
G
D
---
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
------
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
------
D
T
P
-----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
----------------
A
K
S
D
P
P
T
LLTPSKW
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
-----
S
A
A
Q
L
L
E
H
P
F
V
S
------
S
I
T
S
N
K
A
L
R
E
L
V
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.05
35%
-43
- C1 -
-
3NCG
1
?
A:
[22-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
G
-
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
---
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
-----
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.46
37%
-30
- C1 -
-
2JFM
2
SLK_HUMAN
A:
[39-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
T
K
-------
S
------
E
E
-
E
L
E
D
-
Y
M
V
E
I
D
I
L
A
S
C
-
D
-
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
A
-
G
-
G
A
V
D
A
V
M
L
E
L
--
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
---
L
D
---
G
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
------
D
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
KSEPPT
L
A
Q
P
S
R
W
S
-
S
N
---------------
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.35
35%
-34
- C1 -
-
3IGO
8
?
A:
[22-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
--
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
-
G
-
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
---
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
56.82
35%
-2
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[94-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
-------
R
LSPEQL
E
E
-
V
R
E
A
-
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
-
L
M
R
K
G
-
E
L
F
D
--
Y
L
T
E
--
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
---
D
N
---
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
-
K
L
R
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
P
G
-----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
-------
M
E
G
Q
Y
Q
F
S
-
S
P
E
W
D
D
R
-------
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.82
35%
-51
- C1 -
-
3DFA
-
?
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
-------
K
------
N
K
-
D
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
---
E
L
F
D
--
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
-------
K
D
---
C
D
---
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
M
K
D
R
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
-------
G
T
-----
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
G
K
Y
A
F
D
-
L
P
Q
W
R
T
I
-------
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
------
K
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.09
37%
-50
- C1 -
-
4USF
1
SLK_HUMAN
A:
[18-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
T
K
-------
S
------
E
E
-
E
L
E
D
-
Y
M
V
E
I
D
I
L
A
S
C
-
D
-
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
A
-
G
-
G
A
V
D
A
V
M
L
E
L
--
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
---
L
D
---
G
D
---
I
K
L
A
D
F
G
V
S
A
K
--------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----------
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
Q
P
S
R
W
S
-
S
N
---------------
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
55.82
37%
-38
- C1 -
-
2J51
5
SLK_HUMAN
A:
[39-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
--
D
T
K
-------
S
------
E
E
-
E
L
E
D
-
Y
M
V
E
I
D
I
L
A
S
C
-
D
-
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
A
-
G
-
G
A
V
D
A
V
M
L
E
L
--
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
---
L
D
---
G
D
---
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
-
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
------
D
R
P
-----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
Q
P
S
R
W
S
-
S
N
---------------
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
-----
T
T
S
Q
L
L
Q
H
P
F
V
T
------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------