@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_13_0670: (2018-03-08 )
MRIRLLACSRVEYGRVGPLKQCFPLISPGLLAHTSSRDSVCASAEAHPVLSTTVVLLPSSLFSLCRCSVKASGEATVLNGEGGARVVSAVHQAHPHEPLVGLMTQPLPLSTILRHPLASKRCMMIFHQNGEETMELFELLSRYEAVGPIGQGSYGYVCSARDNDLVERFQAKPPEEYEDASLTLEEREEVYDTNTLVAIKKLRQLFENNQPRMWLCATREIQLMMAFQHDNVMSATDFFIPLGGVEMMTYDSILQLQHTFDGVYVVMKKMDYTLREVLDSTIVTAAELAPGYETWLRRLRLLMANCGEVNADVSSTPTPVRASRLNVKAEAQGEDQAAAAPHSSTEQSRSGGREDVEDEAGATVPSSLDYPVAAAAAAAAPTNDHDAPVAKTSTDGGFEGKGGGDDEGAPVCCPLTTVALHSLTRDYRKFILYQIFRGVGYLHLCPVIHRDLKPENIMLDRSYGTRITDFGQGRDVGLNATTDYVQTVLDNCTQWYAAPETLTVAINSPMGFIDHDSFHGVDVWSIGCIAAEMLIGRPLFYTTSMGGKSQLLSIFRVLGEPSASAIESIAEYRDKETRELFMNSVKKLVKTAPPSNTITPTLAELLRSPYGDEDEDEVGLIIDCLRWDPRERITIQAALQNPFFTKDGYDPVIDPEDTAKRVPSVRPEDISEPVSGRAFLWNLFLERHPEVKELWNSLVAKHEEELKVKKAAADT
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-.......150.......160.......170.......180.......190.......200......-.210.......220.....-..230.......240.......250.......260.......270........280.......290.......300.......310...--....320.......330.......340.......350.......360.......370.......380.......390.......400.---------......410..------.....420--.--------.......430.......440.......450.......460.---......--.470..--.....-480---------........490.......500.......510.......520.......530.......540.....---------------.---.550.......560.......570.......580.......590.......600.....--..610.......620.......630.......640......------.650.......660....-...670-........680.......690.......700.......710...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
I
R
L
L
A
CSRVEYGRVG
P
L
K
Q
C
F
P
LISP
G
L
LAHTSSRDSVCASAEAHP
V
L
S
T
T
V
V
L
L
P
S
S
L
F
S
L
C
R
C
SVKASG
E
A
T
V
LNGEG
G
A
R
V
V
S
A
V
H
QAHPHE
P
L
V
G
L
MTQPL
P
L
S
T
I
L
RHPLASK
R
C
M
M
I
F
HQN
G
E
E
T
M
E
L
F
E
L
L
S
R
-
Y
E
AVGPIGQGSY
G
Y
V
CSARD
N
D
L
V
E
R
FQAKPPEEYEDASL
T
L
E
E
R
E
E
VYDT
N
T
L
V
A
I
K
K
L
R
Q
L
F
EN-NQ
P
R
M
W
L
C
AT
R
E
I
Q
L
M
M
A
F-QHDNVMSA
T
D
F
F
I
PLG
G
V
E
M
M
T
Y
D
S
I
L
Q
L
Q
H
TF
D
G
V
Y
V
V
M
K
KM
D
-
Y
T
L
R
E
V
L
D
S
T
I
V
T
A
A
ELA
P
G
Y
E
T
W
L
R
R
L
R
L
L
M
A
NCGEVNADVSS--TPTP
V
R
A
S
R
L
N
V
K
A
EAQGEDQAAAAPHSS
T
E
QSRSGGRED
V
E
DEAGATVPSSLDYP
V
A
A
A
AAAAAPTNDHDAPVAKTSTDGGFEGKGG---------GDDEGA
P
V
CC
P
------
L
T
T
V
A
L
H
---
S
--------
L
T
R
D
Y
R
K
F
I
L
Y
Q
I
F
R
GV
G
Y
L
H
L
C
P
V
I
H
RDLKPE
N
I
M
L
DR-S---YGTRIT--DFGQGR--DVGLN-A
T
----------
T
D
Y
V
Q
T
V
L
DN
C
T
Q
W
YAAP
E
T
L
T
V
A
INSPMGFIDHDSFHG
V
D
V
W
S
I
G
C
I
A
A
E
M
L
IGRP
L
F
Y
TTSMG
G
---------------
K
---
S
Q
L
L
S
I
F
R
V
LGEP
S
A
S
A
I
E
S
I
A
E
Y
R
D
K
E
T
R
E
L
F
M
N
S
V
K
K
L
V
KTAPPSNTI
T
P
T
L
A
E
L
L
R--SPYGDEDEDEV
G
L
I
I
D
CLRWDPR
E
R
I
T
I
Q
A
ALQNPFFTKDG------YDPVIDP
E
D
T
A
K
RVPSVR-
P
E
D
IS--EPVS
G
R
A
F
L
W
N
L
F
L
E
RHP
E
V
K
E
L
W
N
S
L
V
A
K
H
E
E
E
L
K
V
K
KAAADT
22
HHSearch
94.32
34%
-121
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[2-303]
----------------------------------------------------------------------------------------------------------------------------------------
F
D
V
G
D
E
-
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
----------------------------
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
-
V
--
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
-
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
------------
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
-
S
D
L
H
Q
I
I
H
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---
P
--------
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
---
C
E
L
K
I
G
--
D
F
G
M
A
R
--
G
L
C
T
S
-
P
A
----------
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
---------
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
--
Y
---------------
V
---
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
----
A
Y
I
---
Q
S
L
P
P
R
Q
P
------
V
P
----
W
E
--
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
-----------------------------------------------------------------------------
40
HHSearch
88.60
32%
-121
- C1 -
-
3COI
-
MK13_HUMAN
A:
[17-312]
--------------------------------------------------------------------------------------------------------------------------------------
T
A
W
E
L
P
K
T
-
Y
V
S
P
T
H
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
----------------------------
S
G
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
---
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
-
Q
H
E
N
V
I
G
L
L
D
V
F
T
P
A
S
S
L
------------
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
-
T
D
L
Q
K
I
M
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
-
D
---
C
E
L
K
I
L
--
D
F
G
L
A
R
--
H
--------------------------
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
---------
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
--
Y
---------------
L
---
D
Q
L
T
Q
I
L
K
V
T
G
V
P
G
T
E
F
V
Q
K
L
N
D
K
A
A
K
----
S
Y
I
Q
S
---
L
P
Q
------
T
P
R
K
D
----
F
T
--
Q
L
F
P
R
A
S
P
Q
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
----------------------------------------------------------------------------
35
HHSearch
88.24
34%
-129
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[12-308]
-------------------------------------------------------------------------------------------------------------------------------------
K
T
I
W
E
V
P
E
R
-
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
----------------------------
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
---
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
-
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
------------
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
-
A
D
L
N
N
I
V
K
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
-
D
---
C
E
L
K
I
L
--
D
F
G
L
A
R
--
H
T
D
D
E
-
M
T
-----------------
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
---------
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
--
H
---------------
I
---
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
----
N
Y
I
Q
---
S
L
T
Q
-
M
P
-------
K
--
M
N
F
A
--
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
-----------------------------------------------------------------------------
25
HHSearch
85.20
31%
-120
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[8-312]
---------------------------------------------------------------------------------------------------------------------------------------
V
F
D
V
G
P
R
-
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
----------------------------
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
----
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
-
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
-------------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
-
T
D
L
Y
K
L
L
K
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--------
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
-
T
---
C
D
L
K
I
C
--
D
F
G
L
A
R
--
V
A
D
P
D
-
H
D
----------
H
T
G
F
-
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
---------
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
--
Y
---------------
L
---
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
----
N
Y
L
L
S
-------
L
P
H
--
K
N
----
K
V
P
W
N
--
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
-----------------------------------------------------------------------------
43
HHSearch
84.37
31%
-116
- C1 -
-
4XNE
1
MK01_RAT
A:
[7-307]
--------------------------------------------------------------------------------------------------------------------------------------
Q
V
F
D
V
G
P
R
-
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
----------------------------
N
K
V
R
V
A
I
K
K
I
S
P
F
E
H
----
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
-
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
-------------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
-
T
D
L
Y
K
L
L
K
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--------
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
-
T
---
C
D
L
K
I
C
--
D
F
G
L
A
R
--
V
A
D
P
D
-
H
D
----------
H
T
G
F
-
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
---------
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
--
Y
---------------
L
---
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
----
Y
L
L
S
L
-------
P
H
--
K
N
----
K
V
P
W
N
--
R
L
F
P
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
----------------------------------------------------------------------------
27
HHSearch
82.54
33%
-57
- C1 -
-
5CI6
-
MPK6_ARATH
B:
[30-326]
---------------------------------------------------------------------------------------------------------------------------------------
I
F
E
V
T
A
K
Y
K
P
P
I
M
P
I
G
K
G
A
Y
G
I
V
C
S
A
M
N
S
E
----------------------------
T
N
E
S
V
A
I
K
K
I
A
N
A
F
D
N
-
K
--
I
D
A
K
R
T
L
R
E
I
K
L
L
R
H
M
-
D
H
E
N
I
V
A
I
R
D
I
I
P
P
P
L
-------------
R
N
A
F
N
D
V
Y
I
A
Y
E
L
M
D
-
T
D
L
H
Q
I
I
R
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---
A
--------
L
S
E
E
H
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
A
-
N
---
C
D
L
K
I
C
--
D
F
G
L
A
R
--
V
T
--------------------------
V
T
R
W
Y
R
A
P
E
L
L
L
N
S
---------
S
D
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
R
K
P
L
F
P
G
R
D
--
H
---------------
V
---
H
Q
L
R
L
L
M
E
L
I
G
T
P
S
---
L
E
F
L
N
E
N
A
-----
K
R
Y
I
---
R
----
Q
L
P
P
------
Y
P
R
Q
S
I
T
--
D
K
F
P
T
V
H
P
L
A
I
D
L
I
E
K
M
L
T
F
D
P
R
R
R
I
T
V
L
D
A
L
A
H
P
Y
L
N
S
L
-----------------------------------------------------------------------------
32
HHSearch
81.01
31%
-96
- C1 -
-
3N9X
4
?
B:
[23-372]
-----------------------------------------------------------------------------------------------------------------------------------------
H
V
P
D
N
-
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
----------------------------
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
-
L
--
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
-
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
-------------
L
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
-
S
D
L
K
K
L
F
K
T
P
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
-
D
---
C
S
V
K
V
C
--
D
F
G
L
A
R
--
T
I
N
----------------------
S
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
---------
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
M
L
Q
S
H
I
N
D
P
T
N
R
FPLFPGSSCFH
E
K
S
N
R
---
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
-
K
P
-------
E
V
I
K
Y
I
K
L
----
F
P
H
--
R
K
P
----
I
N
L
K
--
Q
K
Y
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
----------------------------------------------------------------------------
26
HHSearch
80.84
34%
-145
- C1 -
-
2FST
3
MK14_HUMAN
X:
[22-318]
-------------------------------------------------------------------------------------------------------------------------------------
K
T
I
W
E
V
P
E
R
-
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
----------------------------
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
-
I
--
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
-
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
------------
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
-
A
D
L
N
-----
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
-
D
---
C
E
L
K
I
L
--
D
-----------------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
---------
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
--
H
---------------
I
---
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
S
E
S
A
R
----
N
Y
I
Q
S
L
T
Q
----
M
P
-------
K
M
--
N
F
A
--
N
V
F
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
-----------------------------------------------------------------------------
41
HHSearch
77.62
29%
-106
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
----------------------------
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
-
E
--
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
-
K
H
K
N
I
V
R
L
H
D
V
L
H
------------------
S
D
K
K
L
T
L
V
F
E
F
C
D
-
Q
D
L
K
K
Y
F
D
S
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
D
--------
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
---
G
E
L
K
L
A
--
N
F
G
L
A
R
--
A
F
G
I
P
-
V
R
----------
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
---------
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
-
V
---------------
D
---
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
---
Y
--------
P
M
Y
P
----
A
T
T
S
L
V
------
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-----------------------------------------------------------------------------
30
HHSearch
73.04
31%
-7
- C1 -
-
3OZ6
-
?
A:
[6-341]
-----------------------------------------------------------------------------------------------------------------------------------------
H
V
L
R
K
-
Y
E
L
V
K
K
-------
I
V
W
K
S
I
D
R
R
----------------------------
T
G
E
V
V
A
V
K
K
I
F
D
--
Q
N
-
S
--
T
D
A
Q
R
T
F
R
E
I
M
I
L
T
E
L
S
G
H
E
N
I
V
N
L
L
N
V
L
R
A
D
----------------
N
D
R
D
V
Y
L
V
F
D
Y
M
E
-
T
D
L
H
A
V
I
R
A
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--------
L
E
P
V
H
K
Q
Y
V
V
Y
Q
L
I
K
V
I
K
Y
L
H
S
G
G
L
L
H
R
D
M
K
P
S
N
I
L
L
N
A
-
E
---
C
H
V
K
V
A
--
D
F
G
L
S
R
--
S
F
V
N
I
-
R
R
V
T
N
NIPLSIN--------
Y
V
A
T
R
W
Y
R
A
P
E
I
L
L
G
S
---------
T
K
Y
T
K
G
I
D
M
W
S
L
G
C
I
L
G
E
I
L
C
G
K
P
I
F
P
G
S
S
--
T
---------------
M
---
N
Q
L
E
R
I
I
G
V
I
D
F
P
S
N
E
D
V
E
S
I
Q
S
P
F
A
K
----
T
M
I
E
S
L
K
E
K
V
E
----
K
R
D
I
F
T
K
W
K
N
L
L
L
K
I
N
P
K
A
D
C
N
E
E
A
L
D
L
L
D
K
L
L
Q
F
N
P
N
K
R
I
S
A
N
D
A
L
K
H
P
F
V
S
I
F
-----------------------------------------------------------------------------
24
HHSearch
71.58
31%
-96
* C1 *
-
1J1B
1
GSK3B_HUMAN
B:
[54-343]
--------------------------------------------------------------------------------------------------------------------------------------------
V
S
-
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
----------------------------
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
---------
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
------------
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
-
E
T
V
Y
R
V
A
R
H
Y
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Q
---
T
--------
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
---
A
V
L
K
L
C
--
D
F
G
S
A
K
--
Q
L
V
R
G
-
E
P
---------------
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
---------
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
--
G
---------------
V
---
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
----
E
-
F
K
--
F
P
Q
I
K
---------
A
H
P
W
T
---
K
--
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
-----------------------------------------------------------------------------
31
HHSearch
71.40
31%
-107
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-298]
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
----------------------------
T
N
Q
I
V
A
I
K
K
I
------------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
-
S
H
P
N
I
I
G
L
L
D
A
F
G
H
------------------
K
S
N
I
S
L
V
F
D
F
M
E
-
T
D
L
E
V
I
I
K
D
N
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
V
--------
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
-
N
---
G
V
L
K
L
A
--
D
F
G
L
A
K
--
S
F
G
S
P
-
N
R
-----------
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
---------
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
--
D
---------------
L
---
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
Y
V
T
----
F
-------
K
S
F
P
-----
G
I
P
L
----
H
--
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
-----------------------------------------------------------------------------
6
PsiBlast_PDB
56.40
31%
-134
- C1 -
-
5BYY
1
MK07_HUMAN
A:
[106-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
---
C
E
L
K
I
G
--
D
F
G
M
A
R
--
G
L
------------------
Y
F
M
T
E
Y
-
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
---------
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
---------------
Q
---
L
Q
L
--
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-----------
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
------
W
E
--
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
-
Y
------
H
D
P
D
D
E
P
D
--------------------------------------------------------------
2
PsiBlast_PDB
55.19
31%
-145
- C1 -
-
4B99
1
MK07_HUMAN
A:
[155-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
---
C
E
L
K
I
G
--
D
F
G
M
A
R
--
G
L
-----------------
Q
Y
F
M
T
E
Y
-
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
---------
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
---------------
Q
---
L
Q
L
--
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
-----
R
-----------
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
------
W
E
--
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
-
Y
------
H
D
P
D
D
E
P
D
--------------------------------------------------------------
7
PsiBlast_PDB
52.83
31%
-88
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[107-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
---
C
E
L
K
I
G
--
D
F
G
M
A
R
--
G
L
C
T
S
P
A
E
----------
H
Q
Y
F
M
T
E
Y
-
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
---------
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
---------------
Q
---
L
Q
L
--
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-----------
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
------
W
E
--
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
-
Y
------
H
D
P
D
D
E
P
D
--------------------------------------------------------------
53
Fugue
52.36
20%
12
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
-
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
--
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
-
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
WITTLH
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
YYVGGD
L
L
T
L
L
S
K
F
ED
R
--------
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
-
N
---
G
H
I
R
L
A
--
D
F
G
S
C
L
--
K
L
M
E
D
-
G
T
-------------
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
G
G
K
G
R
Y
G
P
-----
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
-----------------------------------------------
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
-
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
--
R
L
I
C
S
R
E
H
----------
R
L
G
Q
N
G
---
I
E
D
F
K
K
H
P
F
F
S
G
I
D
------
W
D
N
I
R
N
C
E
--
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
NF
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
----------------
13
PsiBlast_PDB
52.36
32%
-48
- C1 -
-
3SA0
1
MK01_HUMAN
A:
[121-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
-
T
---
C
D
L
K
I
C
--
D
F
G
L
A
R
VA
D
P
D
H
D
-
H
T
GFL-------
T
E
Y
V
------
A
T
R
W
Y
R
A
P
E
---
I
M
L
N
S
K
-
G
Y
T
K
-----
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
-----
P
G
---------------
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
----
Y
L
L
S
L
P
H
--
K
N
K
V
P
W
N
R
L
F
P
-------------
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
-
Y
------
Y
D
P
S
D
E
P
---------------------------------------------------------------
46
Fugue
52.32
19%
29
- C1 -
-
1KOB
1
?
A:
[23-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
---
N
L
H
D
A
F
E
D
K
-------------
Y
E
M
V
L
I
L
E
F
------
L
S
G
G
E
L
F
---
D
R
I
A
AEDYK
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
-
K
---
K
A
S
S
V
K
II
D
F
G
L
A
T
--
K
L
N
P
D
-
E
I
----------
V
K
V
T
T
A
-----
T
A
E
F
A
A
P
E
I
V
D
---
R
E
P
V
G
-------
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
-----------------------------------
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
--------------
S
S
V
S
P
E
A
K
D
F
I
K
--
N
L
---------------
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
SNLTSR
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
-
D
W
P
A
P
--
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-----------
3
PsiBlast_PDB
51.71
31%
-89
- C1 -
-
4ZSL
4
MK07_HUMAN
A:
[102-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
---
C
E
L
K
I
G
--
D
F
G
M
A
R
--
G
L
C
T
S
P
A
E
----------
H
Q
Y
F
M
T
E
Y
-
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
---------
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
---------------
Q
---
L
Q
L
--
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-----------
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
------
W
E
--
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
-
Y
------
H
D
P
D
D
E
P
D
--------------------------------------------------------------
44
HHSearch
51.63
23%
-37
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-293]
-----------------------------------------------------------------------------------------------------------------------------------------
L
F
E
D
V
-
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
----------------------------
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
P
G
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
------------------
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
---
V
--------
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
P
V
K
L
G
--
G
F
G
V
A
I
--
Q
L
G
E
S
-
G
L
----------
V
----
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
----------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
---------------------
R
L
F
E
G
I
I
K
---------------
G
K
-------
Y
--------
K
M
N
P
----------------
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------
17
PsiBlast_PDB
51.53
32%
-50
- C1 -
-
4FV7
4
MK01_HUMAN
A:
[121-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
-
T
---
C
D
L
K
I
C
--
D
F
G
L
A
R
VA
D
P
D
H
D
-
H
T
GFL-------
T
E
Y
V
------
A
T
R
W
Y
R
A
P
E
---
I
M
L
N
S
K
-
G
Y
T
K
-----
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
-----
P
G
---------------
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
----
Y
L
L
S
L
P
H
--
K
N
K
V
P
W
N
R
L
F
P
-------------
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
-
Y
------
Y
D
P
S
D
E
P
---------------------------------------------------------------
18
PsiBlast_PDB
51.33
32%
-47
- C1 -
-
4G6O
5
MK01_HUMAN
A:
[121-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
-
T
---
C
D
L
K
I
C
--
D
F
G
L
A
R
VA
D
P
D
H
D
-
H
T
GFL-------
T
E
Y
V
------
A
T
R
W
Y
R
A
P
E
---
I
M
L
N
S
K
-
G
Y
T
K
-----
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
-----
P
G
---------------
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
----
Y
L
L
S
L
P
H
--
K
N
K
V
P
W
N
R
L
F
P
-------------
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
-
Y
------
Y
D
P
S
D
E
P
---------------------------------------------------------------