@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_06_1220: (2018-07-12 )
MNQNPAAQAGDKVPNMSNARRGETSDDYARHKAAASRAFLENHYQSLLANTRNGVGRAVGPRQKEPSFSDFHLFKCIGRGAFGEVFVCKYKSDKTDTLYALKRLRKSDMITKKQVVHVRSEKDVLAEAAASNPWVVHLYRSFQDSLYLYMVMEYMPGGDMISWLCDKGIFDVESTRFYIAELCAAVASVHDMGFVHRDIKPDNILFGESGHIKLSDFGLSKRFVEKRGNLLDYDDPSSSSNGAEASADEKSAYESRTDAPSGSPSGDGAGTGIAHGRVREMFQSIVGSPGYIAPEILLRKPYGVGCDWWSVGVIMYEMLYGIPPFFSQNPNSTCHKIKNWREHLVFPPQRHIPDDAVDFMKRLICEPEKRMTYDEICHHDFLKPMDMNGLLKLQAPYVPALSNRLDTKYFPEIKEPSAPMQQSEEQKVREVDPRGVMFADFRFNYSGDQAGPASA
Atome Classification :
(26 SA)
---.........10.......--.20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160....-.-..170--.......180.......190........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......-----300---.----........310.......320.......330.......340.......-350........360...-..---..--370----.-----.------.-.....380.--......390.--........400.......410.......420....-...430.......440.......450...-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MNQNPAAQAGDKVPNMSN--ARRGET
S
D
D
Y
A
R
H
K
A
A
A
S
R
A
F
L
E
N
H
Y
Q
S
L
L
A
NTRNGVGRAVGPRQKEPSF
S
D
F
H
L
F
K
C
I
GRGAFG
E
V
F
V
C
K
YKSDKT
D
T
L
Y
A
L
K
R
L
R
K
SDMI
T
K
K
Q
V
V
H
VRSE
K
D
V
L
A
E
AAASN
P
W
V
V
H
L
Y
R
S
F
Q
D
S
L
Y
L
Y
M
V
M
E
YMPG
G
D
M
I
S
W
L
C
D-K-GIFDV--
E
S
T
R
F
Y
I
A
E
L
C
A
A
V
A
S
V
H
D-M
G
F
V
HRDIKPD
N
I
L
FGESG
H
I
K
L
SDFG
L
S
K
R
F
V
E
KRGNLLDYDDPSSSSNGAEASAD
E
K
S
AYESRTDAPSGSPSGDGAGTGIA
H
G
R
V
R
E
M
F
Q
S
I
VGSPGYI
A
P
E
I
LLR-----K-----P----YGVG
C
D
W
W
S
V
G
V
I
M
Y
E
M
L
YGIPPFFSQNPN
S
T
C
H
K
I
K
N
W
R
E
HLVFPPQ-R-HIP
D
D
A
V
D
F
M
K
R
L
IC-EP---EK--RM-----
T
-----
Y
------
D
-
E
I
C
H
H
DFLK--PMDMN
G
L
--
L
--
K
LQAPYV
P
A
L
SNRLDTKYFPEIKEPSAPM
Q
Q
S
E
E
Q
-
K
V
REVDPRG
V
M
F
A
D
F
R
F
NYSGDQAGPASA-
29
HHSearch
87.50
43%
0
- C- -
-
4LQQ
1
CBK1_YEAST
A:
[97-480]
--------------------------------------------------------------------
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
--
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
---------------
S
--
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
-
W
-
Q
L
F
T
E
--
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
-----------------------------
L
T
M
S
N
R
Q
Q
I
Q
T
W
R
K
S
R
--
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
-----
Q
-----
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
-
I
-
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
QRL
G
R
--
H
G
-----
G
-----
A
------
D
-
E
I
K
S
H
P
F
F
R
--
G
V
D
W
N
T
I
--
R
--
Q
V
E
A
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
P
T
D
--------------------------------------------
28
HHSearch
86.57
43%
0
- C- -
-
4LQS
1
CBK1_YEAST
A:
[97-480]
--------------------------------------------------------------------
T
R
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
--
T
G
K
I
Y
A
M
K
T
L
L
K
S
E
M
Y
K
K
---------------
S
--
D
S
P
W
V
V
S
L
Y
Y
S
F
Q
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
-
W
-
Q
L
F
T
E
--
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
F
I
H
R
A
I
K
P
D
N
I
L
I
D
I
R
G
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
Y
---------------------------------
N
R
Q
Q
I
Q
T
W
R
K
S
R
--
R
L
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
Y
-----
Q
-----
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
Q
T
L
Q
F
P
D
D
-
I
-
H
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
QRL
G
R
--
H
G
-----
G
-----
A
------
D
-
E
I
K
S
H
P
F
F
R
--
G
V
D
W
N
T
I
--
R
--
Q
V
E
A
P
Y
I
P
K
L
S
S
I
T
D
T
R
F
F
P
T
D
--------------------------------------------
45
Fugue
78.67
35%
2
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
GQ
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
--
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
--
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
-
D
R
L
P
E
--
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
-------------------------------------------------
D
G
T
V
Q
S
--
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
-----
M
E
GGKG
R
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
-
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
---
E
H
--
R
L
GQN--
G
-----
I
------
E
-
D
F
K
K
H
P
F
F
S
--
G
I
D
W
D
N
I
--
R
--
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
-------------------
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
22
HHSearch
78.40
39%
-56
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[65-397]
---------------------------------------------------------------------
R
M
K
A
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
--
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
--
D
V
P
E
--
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
---------------------------------------------------
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
---
V
R
LG
R
N
-----
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
--
N
D
Q
W
A
W
E
TL
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
D
K
G
E
E
E
T
F
P
I
P
-
K
A
F
V
G
--
N
Q
L
P
F
V
G
F
T
Y
-
Y
S
N
---------
21
HHSearch
78.25
37%
-65
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[65-395]
---------------------------------------------------------------------
Q
M
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
--
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
--
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
--
D
V
P
E
--
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
---------------------------------------------------
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
N
S
L
C
F
P
E
D
-
A
-
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
---
V
R
LG
R
N
-----
G
-----
V
------
E
-
E
I
R
Q
H
P
F
F
K
--
N
D
Q
W
H
W
D
--
N
IR
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
E
D
--
G
D
V
E
T
F
P
I
P
-
K
A
--
F
V
G
N
Q
L
P
F
I
G
F
T
Y
Y
------------
13
PsiBlast_PDB
77.92
34%
-53
- C1 -
-
5HVU
1
ROCK1_HUMAN
A:
[54-379]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
39
HHSearch
77.36
36%
-104
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[23-321]
--------------------------------------------------------------------
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
--
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
R
F
S
E
--
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
-------------------------------------------------------
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
-----
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
---
T
K
--
R
F
-----
G
NLKN
G
V
------
N
-
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
A
I
--
Y
QR
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----------------------------------------
2
PsiBlast_PDB
77.35
34%
-58
- C1 -
-
3V8S
1
ROCK1_HUMAN
A:
[49-368]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
8
PsiBlast_PDB
77.28
34%
-56
- C1 -
-
3D9V
1
ROCK1_HUMAN
A:
[54-373]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
40
HHSearch
77.16
36%
-103
- C1 -
-
4WIH
-
KAPCA_CRIGR
A:
[39-336]
--------------------------------------------------------------------
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
--
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
R
F
S
E
--
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
-------------------------------------------------------
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
-----
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
---
T
K
--
R
F
-----
G
NLKNG
V
------
N
-
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
A
I
--
Y
QR
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-----------------------------------------
5
PsiBlast_PDB
76.78
34%
-51
- C1 -
-
2ESM
1
ROCK1_HUMAN
A:
[54-373]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
41
HHSearch
76.71
35%
-106
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[38-334]
----------------------------------------------------------------------
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
--
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
-
G
R
F
S
E
--
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
-------------------------------------------------------
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
-----
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
-
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
---
T
K
--
R
F
-----
G
NLKNG
V
------
N
-
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
A
I
--
Y
QR
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
----------------------------------------
3
PsiBlast_PDB
76.58
34%
-53
- C1 -
-
3TV7
2
ROCK1_HUMAN
A:
[49-368]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
G
D
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
14
PsiBlast_PDB
76.49
34%
-56
- C1 -
-
5KKS
1
ROCK1_HUMAN
A:
[54-378]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
6
PsiBlast_PDB
76.29
34%
-56
- C1 -
-
2ETK
1
ROCK1_HUMAN
A:
[54-373]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
27
HHSearch
75.35
32%
-41
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-337]
-----------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
--
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
--
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
V
F
S
E
--
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
----------------------------------------------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
-----
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
--
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
---
K
Q
--
R
L
GGGS
E
D
-----
A
------
K
-
E
I
M
Q
H
R
F
F
A
--
G
I
V
W
Q
H
V
--
Y
EK
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
---S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
----------
23
HHSearch
75.16
37%
-43
- C1 -
-
5OTE
2
?
A:
[73-407]
----------------------------------------------------------------------
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
--
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
--
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
-
F
E
D
K
L
P
E
--
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
---------------------------------------------------
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D--
G
-----
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
-
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
---
R
R
LG
Q
N
-----
G
-----
I
------
E
-
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
N
I
--
R
--
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
----------
I
L
P
P
G
-
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
-----------
15
PsiBlast_PDB
75.09
34%
-57
- C1 -
-
2V55
1
ROCK1_HUMAN
A:
[54-379]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GD
G
Y
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
12
PsiBlast_PDB
74.96
34%
-53
- C1 -
-
5BML
1
ROCK1_HUMAN
A:
[54-378]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
----
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
7
PsiBlast_PDB
74.76
34%
-53
- C1 -
-
2ETR
1
ROCK1_HUMAN
A:
[54-373]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
44
HHSearch
74.31
36%
-101
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[23-319]
---------------------------------------------------------------------
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
--
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
R
F
S
E
--
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
-------------------------------------------------------
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
-----
G
----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
---
T
K
--
R
F
-----
G
NLKDG
V
------
N
-
D
I
K
N
H
K
W
F
A
--
T
T
D
W
I
A
I
--
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
-----------------------------------------
24
HHSearch
73.98
37%
-47
- C1 -
-
5OTF
3
?
A:
[73-408]
----------------------------------------------------------------------
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
M
K
N
--
T
E
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
--
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
-
F
E
D
K
L
P
E
--
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
---------------------------------------------------
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
D
GM
G
-----
K
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
E
E
R
F
Q
F
P
S
H
V
T
-
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
---
R
R
LG
Q
N
-----
G
-----
I
------
E
-
D
F
K
K
H
A
F
F
E
--
G
L
N
W
E
N
I
--
R
--
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
--------
E
I
L
P
P
G
-
S
H
T
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
----------
11
PsiBlast_PDB
73.93
34%
-38
- C1 -
-
4YVE
1
ROCK1_HUMAN
A:
[54-379]
--------------------------------------------------
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
---
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
--
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
--
F
A
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-----
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
-------------------------------------------------
G
M
V
R
--
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
------------GY--
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
L
T
F
P
D
D
-
N
-
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
---
E
V
--
R
L
GRN--
G
-----
V
------
E
-
E
I
K
R
H
L
F
F
K
ND
Q
W
A
W
E
T
L
--
R
--
D
T
V
A
P
V
V
P
D
L
S
S
D
I
D
T
S
N
F
D
D
L
E
E
------------------------------------------
25
HHSearch
72.00
33%
-90
* C1 *
-
4RA5
3
KPCT_HUMAN
A:
[2-327]
----------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
--
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
-
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
-
H
K
F
D
L
--
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
----------------------------------------------------
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
-----
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
---
E
K
--
R
L
-----
G
-----
V
------
R
G
D
I
R
Q
H
P
L
F
R
--
E
I
N
W
E
E
L
--
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
-
A
L
-
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
---------
33
HHSearch
71.07
33%
-85
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[15-341]
---------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
--
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
-
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
-
H
K
F
D
L
--
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
----------------------------------------------------
K
T
N
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
-----
K
----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
---
E
K
--
R
L
-----
G
-----
V
------
R
G
D
I
R
Q
H
P
L
F
R
--
E
I
N
W
E
E
L
--
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
-
A
L
-
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
---------
26
HHSearch
63.05
32%
-85
- C1 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
E
--
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
-
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
-
R
R
F
D
E
--
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------------------------------------------------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
-----
L
----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
T
----
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
---
T
M
--
R
L
-----
G
-----
S
LTQGG
E
H
-
A
I
L
R
H
P
F
F
K
--
E
I
D
W
A
Q
L
--
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
-
G
-
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
----------