@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0341: (2017-12-20 )
MTTNRKDEHILYALEQKSSYNSFDEVELIHSSLPLYNLDEIDLSTEFAGRKWDFPFYINAMTGGSNKGREINQKLAQVAETCGILFVTGSYSAALKNPTDDSFSVKSSHPNLLLGTNIGLDKPVELGLQTVEEMNPVLLQVHVNVMQELLMPEGERKFRSWQSHLADYSKQIPVPIVLKEVGFGMDAKTIERAYEFGVRTVDLSGRGGTSFAYIENRRSGQRDYLNQWGQSTMQALLNAQEWKDKVELLVSGGVRNPLDMIKCLVFGAKAVGLSRTVLELVETYTVEEVIGIVQGWKADLRLIMCSLNCATIADLQKVDYLLYGKLKEANDQMKKA
Atome Classification :
(21 SA)
.........10..----....---.-.20---.........30........40........50........60...-.-..-..70........80........90....-...-.100-..--.-.....110.......120.-----..-..----..130......----.140.......150.......-160-.......170.......180.......190.......200.......210....-...220.---------..--.....230.......240.......250.......260.......270.......280.......290......---.300.......310.......320.......330-------....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTTNRKDE
H
I
L
Y
A
----
L
EQK---S-SY----NSF
D
E
V
E
L
I
H
SSLPLYNLDEIDLSTEFAGRKWDF
P
F
Y
I
N
A
MTGG-S-NK-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
TC
G
I
L
F
V
TGSYSAAL-KNP-TD-D-SF--S-VKSSHP
N
L
L
L
GTNIGLD
K
P
-----
V
E
-
L
G
----
L
Q
T
V
E
EMNP
V
L
----
L
Q
V
H
V
N
V
M
Q
E
L
LMPE
G
E
R
K
F
R
-
S
W
Q
-
S
H
L
A
D
Y
S
KQIPV
P
I
V
L
KEVGFGM
D
A
K
T
I
E
R
A
Y
EFG
V
R
T
V
D
LSGRGG
T
S
F
A
Y
I
EN-RRSG
Q
-
R
---------
D
Y
--
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
VSGGVR
N
P
L
D
M
I
K
C
L
V
FGAKAVG
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
---
D
L
R
L
I
M
CSLNC
A
T
I
A
D
L
Q
K
V
D
Y
L
L
YGK
L
K
E
A
N
D
Q
-------MKKA
34
HHSearch
91.19
99%
-108
- C4 -
-
4N02
1
IDI2_STRPS
A:
[23-354]
-
T
T
N
R
K
D
E
H
I
L
Y
A
----
L
E
Q
K
---
S
-
S
Y
----
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
-
N
K
-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
-
K
N
P
-
T
D
-
D
-
S
F
--
S
-
V
K
S
S
H
P
N
L
L
L
G
T
N
I
G
L
D
K
P
-----
V
E
-
L
G
----
L
Q
T
V
E
E
M
N
P
V
L
----
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
-
S
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
-
R
R
S
G
Q
-
R
---------
D
Y
--
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
---
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
L
K
E
A
K
D
Q
-------
M
---
1
PsiBlast_PDB
90.78
99%
-108
- C4 -
-
4N02
1
IDI2_STRPS
A:
[23-354]
-
T
T
N
R
K
D
E
H
I
L
Y
A
----
L
E
Q
K
---
S
-
S
Y
----
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
-
N
K
-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
-
K
N
P
-
T
D
-
D
-
S
F
--
S
-
V
K
S
S
H
P
N
L
L
L
G
T
N
I
G
L
D
K
P
-----
V
E
-
L
G
----
L
Q
T
V
E
E
M
N
P
V
L
----
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
-
S
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
-
R
R
S
G
Q
-
R
---------
D
Y
--
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
---
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
L
K
E
A
K
D
Q
-------
M
---
22
PsiBlast_CBE
57.55
35%
-33
- C4 -
-
1P0N
2
IDI2_BACSU
B:
[22-331]
---------------------------
E
----
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
-
K
D
P
-
S
E
-
R
L
S
Y
--
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
-----
A
A
-
Q
A
----
K
E
A
V
E
M
I
G
A
N
A
----
L
Q
I
H
L
N
V
I
Q
E
I
V
M
------
F
S
-
G
A
L
-
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
-
I
---------
S
F
--
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
---
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
------------------
3
PsiBlast_PDB
56.89
35%
-30
- C4 -
-
1P0N
1
IDI2_BACSU
A:
[22-331]
---------------------------
E
----
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
-
K
D
P
-
S
E
-
R
L
S
Y
--
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
-----
A
A
-
Q
A
----
K
E
A
V
E
M
I
G
A
N
A
----
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
-
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
-
I
---------
S
F
--
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
---
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
------------------
35
HHSearch
56.03
29%
19
- C4 -
-
3VKJ
1
IDI2_SULSH
A:
[4-354]
-
I
V
N
R
K
V
E
H
V
E
I
A
----
A
F
E
N
VDG
L
S
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
-
E
K
A
E
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYG
L
K
-
E
F
----
Q
D
A
I
Q
M
I
E
A
D
A
----
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
-
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
--
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
---
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
-------
R
---
55
Fugue
55.62
32%
-29
- C4 -
-
1P0K
-
IDI2_BACSU
B:
[22-349]
---------------------------
E
----
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
G
G
-
K
L
-
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
-
K
D
P
-
S
E
-
R
-
L
S
Y
E
I
-
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
-----
A
A
-
Q
A
----
K
E
A
V
E
M
I
G
A
N
A
----
L
Q
I
H
L
N
V
I
Q
E
I
V
M
R
S
----
F
S
-
G
A
L
-
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
R
---------------
Q
-
I
---------
S
F
--
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
---
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
GVNT
S
S
Y
S
V
R
37
HHSearch
55.29
34%
-30
- C4 -
-
1P0K
-
IDI2_BACSU
B:
[22-339]
---------------------------
E
----
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
-
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
-
K
D
P
S
E
R
-
L
-
S
Y
--
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
-----
A
A
-
Q
A
----
K
E
A
V
E
M
I
G
A
N
A
----
L
Q
I
H
L
N
V
I
Q
E
I
V
M
----
R
S
F
S
-
G
A
L
-
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
----------------
R
Q
I
---------
S
F
--
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
---
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
-------
R
---
14
PsiBlast_PDB
55.13
29%
15
- C4 -
-
3VKJ
1
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
2
PsiBlast_PDB
54.90
35%
-28
- C4 -
-
1P0K
-
IDI2_BACSU
A:
[21-331]
--------------------------
R
E
----
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
-
K
D
P
-
S
E
-
R
L
S
Y
--
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
-----
A
A
-
Q
A
----
K
E
A
V
E
M
I
G
A
N
A
----
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
-
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
-
I
---------
S
F
--
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
---
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
------------------
11
PsiBlast_PDB
54.87
29%
20
- C4 -
-
3B04
1
IDI2_SULSH
A:
[6-349]
---
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
5
PsiBlast_PDB
54.85
29%
17
- C4 -
-
2ZRV
1
IDI2_SULSH
A:
[7-349]
----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
36
HHSearch
54.37
29%
27
* C4 *
-
3B05
2
IDI2_SULSH
D:
[3-354]
D
I
V
N
R
K
V
E
H
V
E
I
A
----
A
F
E
N
VDG
L
S
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
-
E
K
A
E
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
VKGYG
L
K
-
E
F
----
Q
D
A
I
Q
M
I
E
A
D
A
----
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
-
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWKAES--
A
K
N-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
---
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
-------
R
---
10
PsiBlast_PDB
54.19
29%
17
- C4 -
-
3B03
1
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
8
PsiBlast_PDB
54.16
29%
16
- C4 -
-
2ZRY
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
7
PsiBlast_PDB
54.10
29%
19
- C4 -
-
2ZRX
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
12
PsiBlast_PDB
54.01
29%
17
- C4 -
-
3B05
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
13
PsiBlast_PDB
53.77
29%
19
- C4 -
-
3B06
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
6
PsiBlast_PDB
53.74
29%
18
- C4 -
-
2ZRW
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
4
PsiBlast_PDB
53.50
29%
9
- C4 -
-
2ZRU
1
IDI2_SULSH
A:
[9-349]
------
V
E
H
V
E
I
A
A
F
EN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
-----
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
9
PsiBlast_PDB
53.48
29%
17
- C4 -
-
2ZRZ
2
IDI2_SULSH
A:
[5-349]
--
V
N
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
---
S
-
S
S
----
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
-
A
R
-
E
-
S
F
--
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
-----
V
K
G
Y
G
----
L
K
E
F
Q
D
A
I
Q
M
I
EAD
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
-
I
R
D
I
R
-
R
GNWK
A
E
S
A
K
N
F
--
L
D
-
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
----
S
A
I
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
---------------
15
PsiBlast_PDB
38.13
33%
5
- C4 -
-
3DH7
1
?
A:
[9-265]
-------
K
H
L
E
A
C
----
L
E
G
E
---
V
-
A
Y
QKTT
T
G
L
E
G
F
R
L
R
Y
Q
A
L
A
G
L
A
L
S
E
V
D
L
T
T
P
F
L
G
K
T
L
K
A
P
F
L
I
G
A
M
T
---------
E
R
I
N
L
A
L
A
E
A
A
E
A
L
G
V
G
M
M
L
G
S
G
R
I
L
L
-
E
R
P
-
E
A
L
R
-
S
F
--
R
-
V
R
K
V
A
P
K
A
L
L
I
A
N
L
G
L
A
Q
L
-----
R
R
-
Y
G
R
D
D
L
L
R
L
V
E
M
L
E
A
D
A
----
L
A
F
H
V
N
P
L
Q
E
A
V
Q
-
R
G
D
T
D
F
R
-
G
L
V
-
E
R
L
A
E
L
L
P
-
L
P
F
P
V
M
V
K
E
V
G
H
G
L
S
R
E
A
A
L
A
L
R
D
L
P
L
A
A
V
D
V
A
G
A
G
G
T
S
W
A
R
V
E
E
W
V
R
F
G
E
-
V
---------
R
H
P
E
L
C
E
I
G
I
P
T
A
R
A
I
L
E
V
R
E
V
L
P
H
L
P
L
V
A
S
G
G
V
--------------------------------------------------------------------------------------------