@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0414: (2017-12-21 )
MLIFPLLNDLSRKIIHIDMDAFFAAVEIKDNPKLRGKPVIIGSDPRQTGGRGVVSTCSYEARAFGVHSAMSSKEAYERCPQAVFISGNYEKYKAVGLQIRAIFKRYTDLIEPMSIDEAYLDVTENKLGIKSAVKIARLIQKDIWQELHLTASAGISYNKFLAKMASDYQKPHGLTVILPEQAEDFLKQMDISKFHGVGKKTVERLHQMGVFTGADLLEVPEVTLIDRFGRLGYDLYRKARGIHNSPVKSNRIRKSIGKEKTYGKILRAEEDIKKELTLLSEKVALNLHQQEKAGKIVILKIRYEDFSTLTKRKSIAQKTQDASQISQIALQLYEELSEKERGVRLLGITMTGF
Atome Classification :
(36 SA)
---------------------------------------------------------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130------------------.........140.......150.......160.......170.......--180.......190.......200.......210.......220.......230...-.....240.......250.......260.......270.--......280.......290--........------300.......310.......320.......330...-....340--.........350.---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------
M
L
I
F
P
L
L
N
D
LSR
K
I
I
H
I
D
M
D
A
F
F
A
A
V
E
IKDNPKLRGK
P
V
I
IGSDPRQTGGRGV
V
S
TCSYE
A
R
A
F
G
VHSAMS
S
K
E
A
Y
E
RCP
Q
A
V
F
ISGN
Y
E
K
Y
K
A
V
G
L
Q
I
R
A
I
F
K
R
Y
T
D
L
IEPMSI
D
E
A
Y
L
D
VTENKL
G
I
K
--------------------
S
A
V
K
I
A
R
L
I
Q
K
D
I
W
Q
E
L
HLTASAGI
S
Y
N
K
F
L
A
K
M
A
S
D
YQKPH
G
L
T
V
IL
P
--
E
Q
A
E
D
F
L
K
QMD
I
S
K
FHGV
G
K
K
T
V
E
R
L
H
QMGVFTG
A
D
LLEVP
E
V
T
L
I
D
R
F
G
R
-
L
G
Y
D
-
L
Y
R
K
ARGIHNSPV
K
S
N
R
I
R
K
S
IGKE
K
T
Y
G
K
I
L
R
A
E
E
D
I
K
--
K
E
L
T
L
L
S
E
K
V
A
L
N
L
H
Q
Q-E--KAG
K
I
V
I
L
------
K
I
R
Y
E
D
F
S
T
L
T
K
R
K
S
I
A
Q
K
T
Q
D
A
S
Q
I
S
Q
I
A
L
Q
L
Y
E
E
-
L
S
E
K
E----RG
V
R
L
L
G
I
TMTGF---
115
HHSearch
89.65
31%
-82
- C1 -
-
4TQR
4
DPO4_SULSO
A:
[1-340]
--------------------------------------------------------------------
M
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
-
I
----
P
K
A
I
H
V
------
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
-
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
113
HHSearch
86.42
31%
-84
- C1 -
-
3RAX
3
DPO4_SULSO
B:
[1-340]
--------------------------------------------------------------------
G
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
-
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
-
I
----
P
K
A
I
H
V
------
V
A
V
T
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
-
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
116
HHSearch
86.35
40%
-85
- C1 -
-
5C5J
5
?
A:
[1-340]
------------------------------------------------------------------
G
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
---
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
--
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-
K
PD
L
L
I
A
R
Q
G
V
------
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
--
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
G
--
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
---
94
PsiBlast_CBE
84.49
31%
-82
- C1 -
-
1S0O
5
DPO4_SULSO
B:
[3-340]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
9
PsiBlast_PDB
84.12
40%
-78
- C1 -
-
4Q44
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
30
PsiBlast_CBE
83.98
40%
-80
- C1 -
-
4R8U
1
?
B:
[1-336]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
50
PsiBlast_CBE
83.75
31%
-77
- C1 -
-
2W9A
3
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
27
PsiBlast_CBE
83.11
40%
-77
- C1 -
-
4IRK
3
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
114
HHSearch
82.94
40%
-93
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[2-340]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
---
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
I
H
H
W
S
E
C
E
--
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
-
K
PD
L
L
I
A
R
Q
G
V
------
K
L
K
F
D
D
F
Q
Q
T
T
Q
E
H
V
W
--
P
R
L
N
K
A
D
L
I
A
T
A
R
K
T
W
D
E
R
R
G
--
G
----
R
G
V
R
L
V
G
L
H
V
T
L
L
---
87
PsiBlast_CBE
82.88
31%
-86
- C1 -
-
1S9F
4
DPO4_SULSO
B:
[3-340]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
22
PsiBlast_CBE
82.71
40%
-74
- C1 -
-
4Q43
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
2
PsiBlast_PDB
82.48
40%
-73
- C1 -
-
4IR9
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
80
PsiBlast_CBE
82.38
31%
-77
- C1 -
-
2C22
3
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
61
PsiBlast_CBE
82.34
31%
-82
- C1 -
-
2RDJ
4
DPO4_SULSO
A:
[3-340]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
65
PsiBlast_CBE
82.31
31%
-81
- C1 -
-
2JEJ
3
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
47
PsiBlast_CBE
82.30
31%
-83
- C1 -
-
2XC9
2
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
97
PsiBlast_CBE
82.20
31%
-80
* C1 *
-
1S0M
6
DPO4_SULSO
B:
[3-340]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
5
PsiBlast_PDB
82.00
40%
-82
- C1 -
-
4R8U
1
DPO4_ECOLI
A:
[1-337]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
36
PsiBlast_CBE
81.92
31%
-80
- C1 -
-
4RZR
3
DPO4_SULSO
A:
[3-340]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
34
PsiBlast_CBE
81.79
31%
-79
- C1 -
-
4TQS
4
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
10
PsiBlast_PDB
81.77
40%
-75
- C1 -
-
4Q45
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
3
PsiBlast_PDB
80.97
40%
-76
- C1 -
-
4Q43
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
26
PsiBlast_CBE
80.61
40%
-78
- C1 -
-
4Q44
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
21
PsiBlast_CBE
79.63
40%
-70
- C1 -
-
5C5J
5
?
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
8
PsiBlast_PDB
79.51
40%
-78
- C1 -
-
4IRK
5
DPO4_ECOLI
B:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
7
PsiBlast_PDB
79.47
40%
-73
- C1 -
-
4IRD
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
25
PsiBlast_CBE
79.30
40%
-76
- C1 -
-
4Q45
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
6
PsiBlast_PDB
79.15
40%
-72
- C1 -
-
4IRC
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
1
PsiBlast_PDB
79.01
40%
-74
- C1 -
-
4IR1
3
DPO4_ECOLI
F:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
HW
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IARQGV
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
29
PsiBlast_CBE
76.57
40%
-75
- C1 -
-
4IRC
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
78
PsiBlast_CBE
76.54
31%
-82
- C1 -
-
2C2D
4
DPO4_SULSO
A:
[9-346]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
P
S
L
K
G
K
P
V
V
V
C
V
F
S
G
R
F
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
I
P
I
V
E
A
K
K
I
L
P
N
A
V
Y
L
P
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
K
V
R
D
Y
R
--------------------
E
A
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
N
G
I
K
V
I
D
D
--
E
E
V
K
R
L
I
R
E
L
D
I
A
D
V
P
G
I
G
N
I
T
A
E
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
-
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
-
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
S
R
N
L
E
E
I
K
--
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
I
P
--
K
A
I
H
V
V
A
V
------
T
---
E
D
L
D
I
V
S
R
G
R
T
F
P
H
G
I
S
K
E
T
A
Y
S
E
S
V
K
L
L
Q
K
I
-
L
E
E
D
E
----
R
K
I
R
R
I
G
V
R
F
S
K
F
---
24
PsiBlast_CBE
76.40
40%
-76
- C1 -
-
4IR1
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
28
PsiBlast_CBE
75.89
40%
-78
- C1 -
-
4IRD
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
23
PsiBlast_CBE
75.28
40%
-73
- C1 -
-
4IR9
5
DPO4_ECOLI
A:
[2-338]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
P
A
L
R
D
I
P
I
A
I
G
G
S
R
E
R
---
R
G
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
C
P
H
L
T
L
L
P
G
R
F
D
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
S
V
H
C
H
G
--------------------
S
A
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
P
--
A
E
V
P
A
F
L
Q
T
L
P
L
A
K
I
P
G
V
G
K
V
S
A
A
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
-
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
L
R
K
S
V
G
V
E
R
T
M
A
------
E
D
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
-
L
--
A
K
V
K
P
D
L
L
IA
R
Q
G
V
K
L
K
F
D
D
F
Q
Q
T
T
Q
-
E
H
V
W
P
R
L
N
K
A
D
L
I
A
-
T
A
R
K
T
W
D
E
--
R
R
G
G
----
R
G
V
R
L
V
G
L
H
V
T
-----
106
Fugue
66.38
33%
18
- C1 -
-
2W7O
3
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
P
E
L
K
D
K
P
I
A
V
G
-------
S
M
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
R
A
A
M
P
G
F
I
A
K
R
L
C
P
Q
L
I
I
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
T
S
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
N
R
Q
A
V
M
D
F
I
K
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
K
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
-
Q
R
A
L
L
S
L
L
F
S
E
-
T
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
I
-
N
K
A
E
E
Q
Y
--
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
-
R
--
L
K
G
R
T
V
T
I
------
K
L
K
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
I
A
K
E
L
L
K
T
-
E
I
D
A
D
FPHP
L
R
L
R
L
M
G
V
R
I
S
S
F
PNE
103
Fugue
62.68
32%
22
- C1 -
-
2OH2
3
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
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