@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0648: (2017-12-26 )
MKMVFLTDLRKHNRIVKSINQTEGYLTTQVAFSYFEKGDQSLTMSEKSQWGSKLGFILASAGSVIGLGSVWKFPYMTAANGGGGFLLIFLISTILIGFPLLLAEFALGRSAGVSAIKTFGKLGKNNKYNFIGWIGAFALFILLSFYSVIGGWILVYLGIEFGKLFQLGGTGDYAQLFTSIISNPAIALGAQATFILLNIFIVSRGVQKGIERASKVMMPLLFIIFVVIIERSLSLPNAMEGVLYFLKPDFSKLTSAGLLYALRQSFFALSLGVTAMLTYASYLDKKTNLVQSRISIVAMNISVSIMAGLAIFQARSPFNIQSEGGPSLVFIVLPQLFDKMPFGTIFYVLFLFATVTSSVVMLEINVDNITNQDNSKRAKWSVILGILTFVFGIPSALSYGVMADVHIFGKAFFDAMDFLVSNLLMPFGALFLSLFTGYIFKKALAMEELHLDERAWKQGLFQV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110......----.120.......130.......140.......150.....-------------------------..160-........170------------.......180...-------....190--------.....---...200.......210.......---220.......230--.....--..240.......250.-.....-.260.......270.......280.......290.......300-------........310.......320..---------.....330.......340---...----.----....350.......360.......370..---.....380.......390.......400...-...-.410.......420.......430.......440.......450.......460.---------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
M
V
F
L
T
D
L
R
K
H
N
R
I
V
K
S
I
NQTE
G
Y
L
T
T
Q
V
A
F
S
Y
F
EKGDQSL
T
M
S
E
K
S
Q
W
G
S
K
L
G
F
I
L
ASAG
S
V
I
GLGSVWKF
P
Y
M
T
AANGGG
G
F
L
L
I
F
L
I
S
T
I
L
I
G
F
P
L
L
L
A
E
F
ALGRSA
G
V
S
A
I
K
T
----
F
G
KLGKNNKY
N
F
I
G
W
I
G
A
F
A
L
F
I
L
L
S
F
Y
S
V
I
G
G
W
I
L
V
Y
L
-------------------------GIEF--G
K
L
F
QLGGT
G
D
------------
Y
A
Q
L
F
T
S
I
ISNP
A
-------
I
ALGA
Q
---------
A
T
F
I
L
---
L
N
I
F
I
V
S
R
G
V
Q
K
G
I
E
R
A
S
K
V
M
M
P
---
L
L
F
I
I
F
V
V
I
I
E
R
S--LSL
P
N
--
A
M
E
G
V
L
Y
FLKP
D
F
S
K
L
-
T
S
A
G
L
-
L
Y
A
L
R
Q
S
F
F
A
L
S
L
G
V
T
A
M
L
T
Y
A
S
Y
L
D
K
K
T
N
L
V
Q
S
R
I
S
I
V
A
M
N
I
--------
S
V
S
I
M
A
G
L
A
I
F
QARSPFNIQSEG---------G
P
S
L
V
F
I
V
L
P
Q
L
F
DKMP----
F
G
T
----
I
----
F
Y
V
L
F
L
F
A
T
VTS
S
V
V
M
L
E
I
NVDNITNQDN---SK
R
A
K
W
S
V
I
L
G
I
L
T
F
V
F
G
I
P
S
A
L
S
Y
G
V
M
A
D
V
-
H
I
F
-
G
K
A
F
F
D
A
M
D
F
L
V
S
N
L
L
M
P
F
G
A
L
F
L
S
L
F
T
G
Y
I
F
K
K
A
L
A
M
E
E
LHL
D
E
R
A
W
K
QGLFQV---------------------------------------------------------------------------
40
Fugue
90.30
39%
-129
- C2 -
-
4US3
11
?
A:
[10-450]
---------------------------------------------
G
R
E
Q
W
A
S
R
L
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
I
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
A
V
G
S
----
F
E
K
L
A
P
G
K
P
W
K
V
A
G
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
G
W
I
L
F
Y
L
-------------------------
F
N
Y
I
T
-
G
Q
L
W
S
A
P
A
E
G
-------------
F
G
G
F
F
E
G
F
I
A
N
P
T
-------
L
P
L
F
W
Q
---------
A
L
F
M
I
---
A
T
I
W
I
V
A
I
G
V
K
K
G
I
E
R
S
N
K
I
L
M
P
---
L
L
G
V
L
L
I
A
L
A
I
Y
S
--
L
T
L
G
G
--
A
K
E
G
L
A
F
L
F
S
P
D
W
S
A
L
-
K
D
P
G
V
Y
L
A
A
I
S
Q
A
F
F
T
L
S
L
G
M
G
A
L
I
T
Y
G
S
Y
V
S
K
D
S
R
L
P
G
A
A
V
S
V
A
G
L
D
T
--------
A
F
A
I
I
A
G
I
M
I
F
P
A
V
F
A
L
G
L
S
P
S
G
---------
G
P
G
L
V
F
V
V
L
P
D
I
F
D
S
I
R
----
L
G
P
----
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
D
---
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
-
T
I
I
P
G
L
N
I
F
D
S
V
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
L
W
I
L
S
L
R
F
I
A
P
I
A
I
L
I
V
F
L
S
A
F----------------------------------------------------------
1
PsiBlast_PDB
88.42
39%
-130
- C2 -
-
4US3
11
?
A:
[11-428]
----------------------------------------------
R
E
Q
W
A
S
R
L
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
I
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
A
V
G
S
----
F
E
K
L
A
P
G
K
P
W
K
V
A
G
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
G
W
I
L
F
Y
L
F
------------------------
N
Y
I
T
--
G
Q
L
W
S
-
A
P
A
E
G
------------
F
G
G
F
F
E
G
F
I
A
N
P
T
-------
L
P
L
F
W
Q
---------
A
L
F
M
I
---
A
T
I
W
I
V
A
I
G
V
K
K
G
I
E
R
S
N
K
I
L
M
P
---
L
L
G
V
L
L
I
A
L
A
I
Y
S
--
L
T
L
G
G
--
A
K
E
G
L
A
F
L
F
S
P
D
W
S
A
L
-
K
D
P
G
V
Y
L
A
A
I
S
Q
A
F
F
T
L
S
L
G
M
G
A
L
I
T
Y
G
S
Y
V
S
K
D
S
R
L
P
G
A
A
V
S
V
A
G
L
D
T
--------
A
F
A
I
I
A
G
I
M
I
F
P
A
V
F
A
L
G
L
S
P
S
G
---------
G
P
G
L
V
F
V
V
L
P
D
I
F
D
S
I
R
----
L
G
P
----
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
D
---
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
-
T
I
I
P
G
L
N
I
F
D
S
V
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
--------------------------------------------------------------------------------
2
PsiBlast_PDB
87.23
39%
-140
- C2 -
-
4US4
4
?
A:
[19-428]
------------------------------------------------------
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
I
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
A
V
G
S
----
F
E
K
L
A
P
G
K
P
W
K
V
A
G
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
G
W
I
L
F
Y
L
F
------------------------
N
Y
I
T
--
G
Q
L
W
S
-
A
P
A
E
G
------------
F
G
G
F
F
E
G
F
I
A
N
P
T
-------
L
P
L
F
W
Q
---------
A
L
F
M
I
---
A
T
I
W
I
V
A
I
G
V
K
K
G
I
E
R
S
N
K
I
L
M
P
---
L
L
G
V
L
L
I
A
L
A
I
Y
S
--
L
T
L
G
G
--
A
K
E
G
L
A
F
L
F
S
P
D
W
S
A
L
-
K
D
P
G
V
Y
L
A
A
I
S
Q
A
F
F
T
L
S
L
G
M
G
A
L
I
T
Y
G
S
Y
V
S
K
D
S
R
L
P
G
A
A
V
S
V
A
G
L
D
T
--------
A
F
A
I
I
A
G
I
M
I
F
P
A
V
F
A
L
G
L
S
P
S
G
---------
G
P
G
L
V
F
V
V
L
P
D
I
F
D
S
I
R
----
L
G
P
----
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
D
---
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
-
T
I
I
P
G
L
N
I
F
D
S
V
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
--------------------------------------------------------------------------------
54
HHSearch
86.97
38%
-129
- C2 -
-
4US3
11
?
A:
[10-431]
---------------------------------------------
G
R
E
Q
W
A
S
R
L
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
I
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
A
V
G
S
----
F
E
K
L
A
P
G
K
P
W
K
V
A
G
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
G
W
I
L
F
Y
L
-------------------------
F
N
Y
I
--
T
G
Q
L
-
W
S
A
P
A
E
G-----------
F
G
G
F
F
E
G
F
I
A
N
P
T
-------
L
P
L
F
W
Q
---------
A
L
F
M
I
---
A
T
I
W
I
V
A
I
G
V
K
K
G
I
E
R
S
N
K
I
L
M
P
---
L
L
G
V
L
L
I
A
L
A
I
Y
S
--
L
T
L
G
G
--
A
K
E
G
L
A
F
L
F
S
P
D
W
S
A
L
K
D
P
G
V
Y
-
L
A
A
I
S
Q
A
F
F
T
L
S
L
G
M
G
A
L
I
T
Y
G
S
Y
V
S
K
D
S
R
L
P
G
A
A
V
S
V
A
G
L
D
T
--------
A
F
A
I
I
A
G
I
M
I
F
P
A
V
F
A
L
G
L
S
P
S
G
---------
G
P
G
L
V
F
V
V
L
P
D
I
F
D
S
I
R
----
L
G
P
----
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
D
---
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
V
L
G
E
V
T
I
I
P
-
G
L
N
I
F
D
S
V
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
-
L
T
D
S
V
W
G
K
L
W
I
----------------------------------------------------------------------------
5
PsiBlast_PDB
84.80
30%
-114
- C2 -
-
3QS6
4
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
P
PTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
V
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
Q
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.50
29%
-114
- C2 -
-
2Q6H
8
?
A:
[4-437]
---------------------------------------------
K
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
P
PTDPDSI
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.37
29%
-115
- C2 -
-
3F3E
8
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.28
29%
-116
- C2 -
-
3F4J
4
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
P
PTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
11
PsiBlast_PDB
83.28
29%
-114
- C2 -
-
3F48
7
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VILGG
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.11
29%
-114
- C2 -
-
2Q72
8
?
A:
[4-437]
---------------------------------------------
K
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
PPPTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.97
29%
-113
- C2 -
-
2A65
6
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
42
Fugue
82.71
28%
-116
- C2 -
-
5I6X
5
SC6A4_HUMAN
A:
[1-544]
-------------------------------------
G
S
Q
G
----
E
R
E
T
W
G
K
K
V
D
F
L
L
S
V
I
G
Y
A
V
D
L
G
N
V
W
R
F
P
Y
I
C
A
Q
N
G
G
G
A
F
L
L
P
Y
T
I
M
A
I
F
G
G
I
P
L
F
Y
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
I
----
W
R
K
I
C
--
P
I
F
K
G
I
G
Y
A
I
C
I
I
A
F
Y
I
A
S
Y
Y
N
T
I
M
A
W
A
L
Y
Y
L
I
S
S
FTDQLPWTSCKNSWNTGN
C
T
N
Y
F
S
E
D
--
N
I
T
W
T
L
H
S
T
S
P
------------
A
E
E
F
Y
T
R
H
V
L
Q
I
H
-------
R
S
K
G
L
Q
DLGGIS
W
Q
L
A
L
C
I
M
---
L
I
F
T
V
I
Y
F
S
I
W
K
G
V
K
T
S
G
K
V
V
W
V
T
A
T
F
P
Y
I
A
L
S
V
L
L
V
R
G
--
A
T
L
P
G
--
A
W
R
G
V
L
F
Y
L
K
P
N
W
Q
K
L
-
L
E
T
G
V
W
I
D
A
A
A
Q
I
F
F
S
L
G
P
G
F
G
V
L
L
A
F
A
S
Y
N
K
F
N
N
N
C
Y
Q
D
A
L
V
T
S
V
V
N
C
--------
M
T
S
F
V
S
G
F
V
I
F
T
V
L
G
Y
M
A
E
M
R
N
E
D
V
S
E
V
A
KDA
G
P
S
L
L
F
I
T
Y
A
E
A
I
A
N
M
P
A
S
T
F
F
A
I
----
I
----
F
F
L
M
L
I
T
L
G
L
D
S
S
F
A
G
L
E
G
V
I
T
A
V
L
D
E
F
P
HVW
A
K
R
R
E
R
F
V
L
A
V
V
I
T
C
F
F
G
S
L
V
T
L
T
F
G
G
A
Y
V
V
-
K
L
L
-
E
E
--
Y
A
T
G
P
A
V
L
T
V
A
L
I
E
A
V
A
V
S
---
W
F
Y
G
I
T
Q
F
C
R
D
V
K
E
M
L
G
F
S
P
G
W
F
W
R
I
C
W
V
A
I
S
P
L
F
L
L
F
I
I
A
S
F
L
M
S
PPQLRLFQYNYPYW
S
I
I
L
G
Y
A
I
G
T
S
SF
I
C
I
P
T
Y
I
A
Y
R
L
I
I
TPGT
F
K
E
R
I
I
K
S
I
TPETP
6
PsiBlast_PDB
82.70
30%
-108
- C2 -
-
3F3D
5
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
G
F
--------------------------
A
I
K
F
L
V
G
L
V
P
E
P
P
P
T
D
P
D
S
I
L
R
P
------
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.62
29%
-115
- C2 -
-
3F3C
6
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.30
30%
-100
- C2 -
-
3QS4
6
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PTD
P
D
S
I
L
R
P
-
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
V
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.21
29%
-105
- C2 -
-
3USK
1
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PTD
P
D
S
I
L
R
P
-
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VILGG
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.93
29%
-108
- C2 -
-
3USJ
1
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PTD
P
D
S
I
L
R
P
-
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VILGG
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.86
29%
-104
- C2 -
-
3USI
1
?
A:
[5-441]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
PPTD
P
D
S
I
L
R
P
-
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VILGG
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.82
30%
-93
- C2 -
-
3F3A
9
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
G
F
--------------------------
A
I
K
F
L
V
G
L
V
P
E
P
P
T
D
P
D
S
I
L
R
P
-------
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.67
29%
-105
- C2 -
-
3USG
4
?
A:
[5-437]
----------------------------------------------
R
E
H
W
A
T
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
F
L
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
Y
L
L
W
R
N
R
F
A
K
I
L
G
V
F
G
L
W
I
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
------------------------------
G
F
--
A
I
K
F
L
V
G
L
V
P
E
P
PTD
P
D
S
I
L
R
P
-
F
K
E
F
L
Y
S
Y
I
G
V
P
K
GDEP
I
L
K
P
S
L
F
A
Y
---------
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
---
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
GT
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
-
K
D
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
L
G
F
G
A
I
I
T
Y
A
S
Y
V
R
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VILGG
S
I
S
I
P
A
A
V
A
F
F
G
V
A
N
A
V
A
I
A
K
A
G
---------
A
F
N
L
G
F
I
T
L
P
A
I
F
S
Q
T
A
----
G
G
T
F
L
G
F
L
----
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
Q
P
M
I
A
F
L
--
E
D
E
---
L
K
L
S
R
K
H
A
V
L
W
T
A
A
I
V
F
---------
F
S
A
H
L
-
V
M
F
-
L
N
K
S
L
D
E
M
D
F
W
A
G
T
I
G
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
----------------------------------------------------------------------------------------