@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0729: (2017-12-28 )
MTQIIDGKALAAKLQGQLAEKTAKLKEETALVPGLVVILVGDNPASQVYVRNKERSALAAGSRSEVVRVPETITQEELLDLIAKYNQDPAWHGILVQLPLPKHIDEEAVLLAIDPEKDVDGFHPLNMGRLWSGHPVMIPSTPAGIMEMFHEYGIDLEGKNAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKVAAKADILVVAIGRAKFVTADFVKPGAVVIDVGMNRDENGKLCGDVDYEAVAPLASHITPVPGGVGPMTITMLMEQTYQAALRTLDRK
Atome Classification :
(31 SA)
.........10........20.......-.-30........40........50........60........70........80........90........100--.--......110.......120.......130...--.--.....140.......150.......160.....-..170.......--180-------..--------......190--.......200.......210.......220.......230-----.-----....------.-..240.......250.......260.......270..---.....280...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTQIID
G
K
A
L
A
A
K
L
Q
G
Q
L
A
E
K
T
A
K
L
K
E
E
-T-ALVP
G
L
V
V
I
L
VGDNPA
S
Q
V
Y
V
RNKE
R
S
A
LAAGSRS
E
V
V
RVPETI
T
Q
E
E
L
L
D
L
I
A
KYNQDPAW
H
G
I
L
V
QLPLPK--H--IDEE
A
V
L
L
A
IDPEKDVDGFHPLNMGRL--WSG--H--
P
V
M
IPST
P
A
G
I
M
E
M
F
H
EYGIDLEGK
N
A
V
V
I
GRS-NIV
G
K
P
M
A
Q
L
L
L--AK--------N
A
--------
T
V
T
L
THSRT--H
N
L
A
K
V
AAKA
D
I
L
V
V
A
IGR
A
K
F
V
T
A
DFVKP
G
A
V
V
I
DVGM------N-----RDEN------G-
K
L
CGDV
D
Y
E
A
V
A
P
L
A
S
HITPVPGGV
G
P
M
T
I
T
M
L
M
E
Q
T
---
Y
Q
A
A
L
R
TLDRK
32
HHSearch
93.30
46%
-126
- C5 -
-
4B4U
4
?
B:
[22-303]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
-----
P
R
D
-------
G
-
G
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
G
--
33
HHSearch
93.05
50%
-123
- C5 -
-
1B0A
-
FOLD_ECOLI
A:
[2-284]
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
A
-
G
-
L
R
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
P
A
--
G
--
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
--
C
Q
R
--
A
--
P
R
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
-
N
I
V
G
R
P
M
S
M
E
L
L
--
L
A
--------
G
C
--------
T
T
T
V
T
H
R
F
T
--
K
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
-----
R
L
E
N
------
G
-
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
---
L
Q
A
C
V
E
Y
H
D
--
3
PsiBlast_PDB
93.03
50%
-124
- C5 -
-
1B0A
-
FOLD_ECOLI
A:
[4-284]
--
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
A
-
G
-
L
R
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
P
A
--
G
--
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
--
C
Q
R
--
A
--
P
R
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
-
N
I
V
G
R
P
M
S
M
E
L
L
--
L
A
--------
G
C
--------
T
T
T
V
T
H
R
F
T
--
K
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
-----
R
L
E
N
------
G
-
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
---
L
Q
A
C
V
E
Y
H
D
--
42
HHSearch
92.84
51%
-127
- C5 -
-
4A5O
-
FOLD_PSEAE
D:
[4-285]
T
A
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
Q
Q
-
G
-
L
R
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
P
A
--
H
--
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
--
A
Q
R
--
M
--
P
L
L
R
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
M
D
A
V
V
V
G
A
S
-
N
I
V
G
R
P
M
A
L
E
L
L
--
L
G
--------
G
C
--------
T
V
T
V
T
H
R
F
T
--
R
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
---------------------------
G
D
V
E
Y
E
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
---
L
H
A
A
E
H
L
H
---
2
PsiBlast_PDB
91.34
51%
-110
- C5 -
-
4A5O
2
FOLD_PSEAE
A:
[6-281]
--
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
Q
Q
-
G
-
L
R
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
P
A
--
H
--
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
--
A
Q
R
--
M
--
P
L
L
R
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
M
D
A
V
V
V
G
A
S
-
N
I
V
G
R
P
M
A
L
E
L
L
--
L
G
--------
G
C
--------
T
V
T
V
T
H
R
F
T
--
R
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
-----
R
Q
A
D
------
G
-
R
L
V
G
D
V
E
Y
E
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
---
L
H
A
A
-------
24
PsiBlast_CBE
90.58
46%
-113
- C5 -
-
4B4U
4
?
B:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
6
PsiBlast_PDB
90.46
46%
-118
- C5 -
-
4B4V
3
?
A:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
23
PsiBlast_CBE
89.95
46%
-114
- C5 -
-
4B4V
3
?
B:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
22
PsiBlast_CBE
89.79
46%
-113
- C5 -
-
4B4W
3
?
B:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
5
PsiBlast_PDB
89.68
46%
-113
- C5 -
-
4B4U
5
?
A:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
47
HHSearch
89.11
50%
-65
- C5 -
-
3P2O
2
FOLD_CAMJE
A:
[3-284]
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
--
K
-
G
I
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
P
D
--
H
--
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
--
N
L
G
--
L
E-
S
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
-
G
R
P
M
A
T
M
L
L
--
N
A
--------
G
A
--------
T
V
S
V
C
H
I
K
T
--
K
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
-----
R
L
E
S
------
G
-
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
---
V
K
S
A
K
N
R
L
---
4
PsiBlast_PDB
88.45
49%
-73
- C5 -
-
3P2O
2
FOLD_CAMJE
A:
[6-284]
---
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
K
---
G
I
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
P
D
--
H
--
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
--
N
L
G
L-
E
--
S
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
-
N
I
V
G
R
P
M
A
T
M
L
L
--
N
A
--------
G
A
--------
T
V
S
V
C
H
I
K
T
--
K
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
-----
R
L
E
S
------
G
-
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
---
V
K
S
A
K
N
R
L
---
46
HHSearch
88.28
50%
-63
- C5 -
-
3P2O
2
FOLD_CAMJE
B:
[3-284]
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
--
K
-
G
I
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
P
D
--
H
--
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
--
N
L
G
--
L
E-
S
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
-
G
R
P
M
A
T
M
L
L
--
N
A
--------
G
A
--------
T
V
S
V
C
H
I
K
T
--
K
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
-----
R
L
E
S
------
G
-
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
---
V
K
S
A
K
N
R
L
---
7
PsiBlast_PDB
88.15
46%
-112
- C5 -
-
4B4W
3
?
A:
[22-302]
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
-
T
-
G
R
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
P
A
--
Q
--
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
--
A
M
G
--
E
--
A
A
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
-
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
A
--------
N
A
--------
T
V
T
I
C
H
S
R
T
--
Q
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
----
R
D
G
G
------
G
---
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
---
V
E
A
A
E
K
A
L
---
15
PsiBlast_PDB
87.09
45%
-74
- C5 -
-
5TC4
2
MTDC_HUMAN
A:
[5-298]
---
V
I
S
G
R
K
L
A
Q
Q
I
K
Q
E
V
R
Q
E
V
E
E
W
V
A
S
-
G
-
N
K
R
P
H
L
S
V
I
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
T
R
A
A
A
V
V
G
I
N
S
E
T
I
M
K
P
A
S
I
S
E
E
E
L
L
N
L
I
N
K
L
N
N
D
D
N
V
D
G
L
L
V
Q
L
P
L
P
E
--
H
--
I
D
E
R
R
I
C
N
A
V
S
P
D
K
D
V
D
G
F
H
V
I
N
V
G
R
M
--
C
L
D
--
Q
--
Y
S
M
L
P
A
T
P
W
G
V
W
E
I
I
K
R
T
G
I
P
T
L
G
K
N
V
V
V
A
G
R
S
-
K
N
V
G
M
P
I
A
M
L
L
H
--
T
D
GAHERPGG
D
A
--------
T
V
T
I
S
H
R
Y
T
P
K
E
Q
L
K
K
H
T
I
L
A
D
I
V
I
S
A
A
G
I
P
N
L
I
T
A
D
M
I
K
E
G
A
A
V
I
D
V
G
I
------
N
-----
R
V
H
-K-----
P
-
K
L
V
G
D
V
D
F
E
G
V
R
Q
K
A
G
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
K
N
T
---
I
I
A
A
K
K
V
L
---
35
HHSearch
87.05
52%
-73
- C5 -
-
3L07
3
FOLD_FRATT
B:
[3-284]
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
H
-
T
-
A
I
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
--
Q
L
R
--
D
K-
K
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
-
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
A
--------
K
A
--------
T
V
T
T
C
H
R
F
T
--
T
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
-----
H
V
D
-------
G
-
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
---
F
Q
C
A
Q
E
L
N
---
34
HHSearch
86.99
48%
-73
- C5 -
-
5TC4
2
MTDC_HUMAN
A:
[2-298]
E
A
V
V
I
S
G
R
K
L
A
Q
Q
I
K
Q
E
V
R
Q
E
V
E
E
W
V
A
S
-
G
-
N
K
R
P
H
L
S
V
I
L
V
G
E
N
P
A
S
H
S
Y
V
L
N
K
T
R
A
A
A
V
V
G
I
N
S
E
T
I
M
K
P
A
S
I
S
E
E
E
L
L
N
L
I
N
K
L
N
N
D
D
N
V
D
G
L
L
V
Q
L
P
L
P
E
--
H
--
I
D
E
R
R
I
C
N
A
V
S
P
D
K
D
V
D
G
F
H
V
I
N
V
G
R
M
--
C
L
D
--
Q
--
Y
S
M
L
P
A
T
P
W
G
V
W
E
I
I
K
R
T
G
I
P
T
L
G
K
N
V
V
V
A
G
R
S
-
K
N
V
G
M
P
I
A
M
L
L
H
--
T
D
--------
G
A
HERPGGDA
T
V
T
I
S
H
R
Y
T
P
K
E
Q
L
K
K
H
T
I
L
A
D
I
V
I
S
A
A
G
I
P
N
L
I
T
A
D
M
I
K
E
G
A
A
V
I
D
V
G
I
------
N
-----
R
V
H
-K-----
P
-
K
L
V
G
D
V
D
F
E
G
V
R
Q
K
A
G
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
K
N
T
---
I
I
A
A
K
K
V
L
---
1
PsiBlast_PDB
86.27
52%
-67
- C5 -
-
3L07
3
FOLD_FRATT
A:
[6-284]
---
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
H
-
T
-
A
I
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
-
L
R
D
--
K
--
K
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
-
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
A
--------
K
A
--------
T
V
T
T
C
H
R
F
T
--
T
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
-----
H
-
V
D
------
G
-
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
---
F
Q
C
A
-
Q
E
L
N
--
21
PsiBlast_CBE
86.20
52%
-70
- C5 -
-
3L07
3
FOLD_FRATT
B:
[6-285]
---
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
H
-
T
-
A
I
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
P
A
--
H
--
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
-
L
R
D
--
K
--
K
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
-
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
A
--------
K
A
--------
T
V
T
T
C
H
R
F
T
--
T
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
-----
H
-
V
D
------
G
-
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
---
F
Q
C
A
-
Q
E
L
N
R
-
13
PsiBlast_PDB
81.26
44%
-80
- C5 -
-
2C2X
-
FOLD_MYCTU
A:
[5-280]
---
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
-
D
A
-
A
-
G
R
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
P
K
--
H
--
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
--
V
L
G
--
T
--
P
A
P
L
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
A
H
V
V
V
I
G
R
G
-
V
T
V
G
R
P
L
G
L
L
L
T
RR
S
E
--------
N
A
--------
T
V
T
L
C
H
T
G
T
--
R
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
-----
R
T
D
D
------
G
--
L
V
G
D
V
-
H
P
D
V
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
---
V
E
L
A
E
R
-----
37
HHSearch
77.76
44%
-10
- C5 -
-
1A4I
1
C1TC_HUMAN
B:
[3-296]
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
V
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
EN
S
--
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
--
D
LN
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
-----
Y
V
P
D
DKKPNG
R
-
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
10
PsiBlast_PDB
77.51
43%
-15
- C5 -
-
1DIB
2
C1TC_HUMAN
A:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
8
PsiBlast_PDB
77.40
43%
-17
- C5 -
-
1A4I
1
C1TC_HUMAN
A:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
36
HHSearch
77.39
44%
-6
* C5 *
-
1A4I
1
C1TC_HUMAN
A:
[3-296]
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
V
P
-
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
EN
S
--
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
--
D
LN
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
-----
Y
-----------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
9
PsiBlast_PDB
76.88
43%
-14
- C5 -
-
1DIA
2
C1TC_HUMAN
A:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
11
PsiBlast_PDB
76.47
43%
-16
- C5 -
-
1DIG
2
C1TC_HUMAN
A:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y----------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
41
HHSearch
76.03
41%
-18
- C5 -
-
4CJX
2
?
B:
[24-317]
E
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
R
Y
K
-
G
R
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
P
P
--
H
--
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
--
H
I
R
--
E
RN
P
A
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
-
D
I
A
G
L
P
V
A
T
L
L
A
--
N
E
--------
D
A
--------
T
V
T
V
V
H
S
A
T
PL
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
------
T
-----
P
V
A
D
PSKVPG
Y
-
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
---
L
T
M
F
K
R
S
V
R
--
25
PsiBlast_CBE
75.61
43%
-0
- C5 -
-
1A4I
1
C1TC_HUMAN
B:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
YVPDD
K
K
P
N
------
G
R
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
27
PsiBlast_CBE
75.60
43%
-1
- C5 -
-
1DIB
1
C1TC_HUMAN
B:
[5-296]
--
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
-
V
P
G
F
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
D
S
--
E
NS
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
--
A
R
G
DL
N
--
D
C
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
-
K
I
V
G
A
P
M
H
D
L
L
L
--
W
N
--------
N
A
--------
T
V
T
T
C
H
S
K
T
--
A
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
YVPDD
K
K
P
N
------
G
R
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
---
V
E
S
A
K
R
F
L
E
--
16
PsiBlast_PDB
73.29
39%
-7
- C5 -
-
4CJX
4
?
A:
[27-318]
---
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
R
Y
K
-
G
R
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
P
P
--
H
--
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
HI
R
E
R
--
N
--
P
A
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
-
D
I
A
G
L
P
V
A
T
L
L
A
--
N
E
--------
D
A
--------
T
V
T
V
V
H
S
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
A
DP
S
-----
K
V
P
G
------
Y
-
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
R
A
----
30
PsiBlast_CBE
73.24
39%
-11
- C5 -
-
4CJX
2
?
B:
[27-318]
---
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
R
Y
K
-
G
R
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
P
P
--
H
--
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
HI
R
E
R
--
N
--
P
A
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
-
D
I
A
G
L
P
V
A
T
L
L
A
--
N
E
--------
D
A
--------
T
V
T
V
V
H
S
A
T
PL
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
TPVADP
S
-----
K
V
P
G
------
Y
-
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
LTM
F
K
R
S
V
R
A
----