@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1135: (2018-01-05 )
MAKKIVALVGDGIGPEIMEAGLEVLEALAEKTGFDYEIDRRPFGGADIDAAGPPLPDETLKASREADAILLVAIGSPQYDGVAVRPEQGLMALRKELNLYANIRPVKIFDSLKYLSPLKPERISGVDFVVVRELTGEIYFGDHILEERKARDINDYSYEEVERIIRKAFEIARNRRKIVTSIDKQNVLATSKLWRKVAEEVAQDFPDVTLEHQLVDSAAMLMITNPAKFDVIVTENLFGDILSDESSVLSGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGIANPISMILSVVMMLRDSFGRYEDTERIKRAVETSLAAGILTRDIGGQASTKEMMEAIIARL
Atome Classification :
(47 SA)
.........10........20........30........40.......-.50........60.........70........80--.---.--.--..-.-..-90........100.......110.......120.-..--.....130.......140----.-.----------...----------.-----..150.......160.......170......-------------.180.......-190...---....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.-......310.......320-....---..----.---330----.----.--.----......340...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
K
K
I
V
A
L
VGDGI
G
P
E
I
M
E
A
G
L
E
V
L
E
A
L
A
E
KTGFDYEIDRRPFGGADI-DAAGPPL
P
D
E
T
L
-
K
ASREA
D
A
I
L
L
V
A
IGSPQYD
G
--
V
---
A
--V--R
P
-
E
-
Q
G
-
L
M
A
L
R
K
E
L
N
L
Y
ANI
R
P
V
K
I
F
D
S
L
K
YLSPLKPE-R-IS--GV
D
F
V
V
V
R
E
LTG
E
I
Y
FG-----
D
-
H
----------
I
L
E
----------
E
-----
R
KARDINDY
S
Y
E
E
V
E
R
I
I
R
K
A
F
E
I
A
RN
R
R
K
I
-------------
V
T
S
IDK
Q
N
V
L
A
-
T
S
K
L
W
R
---
K
V
A
E
E
V
A
Q
DFPD
V
T
L
E
H
Q
L
VDS
A
A
M
L
M
ITNPA
K
F
D
V
I
V
T
E
N
L
F
G
D
I
LSDE
S
S
V
LSGTLGVMPSASHSENGPSLYEPIHGSAPDIAGQGI
A
N
P
I
S
M
I
L
S
V
V
M
M
L
R
D
SFG-RY
E
D
T
E
R
I
K
R
A
V
E
T
S
L
A
A
G
-
I
L
T
R---DI----G---G------Q----A--
S
----
T
K
E
M
M
E
A
I
I
ARL
164
HHSearch
85.38
54%
-2
- C6 -
-
1VLC
-
LEU3_THEMA
A:
[12-362]
-
H
M
K
I
A
V
L
P
G
D
G
I
G
P
E
V
V
R
E
A
L
K
V
L
E
V
V
E
K
K
T
G
K
T
F
E
K
V
F
G
H
I
G
G
D
A
I
-
D
R
F
G
E
P
L
P
E
E
T
K
-
K
I
C
L
E
A
D
A
I
F
L
G
S
V
G
G
P
K
W
D
D
--
L
PP-
E
--
K
--
R
P
-
E
I
G
G
-
L
L
A
L
R
K
M
L
N
L
Y
A
N
I
R
P
I
K
V
Y
R
S
L
V
H
V
S
P
L
K
E
K
-
V
I
G
S
--
G
V
D
L
V
T
V
R
E
L
S
Y
G
V
Y
Y
G
-----
Q
-
P
----------
R
G
L
D
---------
E
-----
E
K
G
F
D
T
M
I
Y
D
R
K
T
V
E
R
I
A
R
T
A
F
E
I
A
K
N
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
Y
-
S
S
M
L
W
R
---
K
V
V
N
E
V
A
R
E
Y
P
D
V
E
L
T
H
I
Y
V
D
N
A
A
M
Q
L
I
L
K
P
S
Q
F
D
V
I
L
T
T
N
M
F
G
D
I
L
S
D
E
S
A
A
L
P
G
S
L
G
L
L
P
S
A
S
F
G
D
-
K
-
N
L
Y
E
P
A
G
G
S
A
P
D
I
A
G
K
N
I
A
N
P
I
A
Q
I
L
S
L
A
M
M
L
E
H
S
F
G
-
M
V
E
E
A
R
K
I
E
R
A
V
E
L
V
I
E
E
G
-
Y
R
T
R
---
D
I
----
A
---
E
------
D
PEKA
V
--
S
----
T
S
Q
M
G
D
L
I
C
K
K
L
1
PsiBlast_PDB
85.14
58%
-2
- C6 -
-
3U1H
-
?
A:
[3-353]
--
K
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
F
E
F
E
Y
G
L
I
G
G
A
A
I
-
D
E
A
G
T
P
L
P
E
E
T
L
-
D
V
C
R
G
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
Q
NP
S
---
E
--
L
--
R
P
-
E
-
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
-
I
E
--
G
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
F
-------------------
E
E
G
----------
E
-----
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
R
K
K
K
-------------
V
T
S
V
D
K
A
N
V
L
E
-
S
S
R
L
W
R
---
E
V
A
E
E
V
A
K
E
Y
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
T
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
L
R
Y
S
F
G
-
L
E
E
E
A
K
A
I
E
K
A
V
E
K
V
L
A
E
G
-
Y
R
T
A
---
D
I
AKPG
G
---
K
------
Y
----
V
--
S
----
T
T
E
M
T
D
E
V
K
A
--
170
HHSearch
84.66
59%
-1
- C6 -
-
3U1H
-
?
B:
[2-355]
-
K
K
K
I
A
V
L
P
G
D
G
I
G
P
E
V
M
E
A
A
I
E
V
L
K
A
V
A
E
R
F
G
H
E
F
E
F
E
Y
G
L
I
G
G
A
A
I
-
D
E
A
G
T
P
L
P
E
E
T
L
-
D
V
C
R
G
S
D
A
I
L
L
G
A
V
G
G
P
K
W
D
Q
--
N
PS-
E
--
L
--
R
P
-
E
-
K
G
-
L
L
G
I
R
K
G
L
D
L
F
A
N
L
R
P
V
K
V
Y
D
S
L
A
D
A
S
P
L
K
K
E
-
V
-
I
E
--
G
V
D
L
V
I
V
R
E
L
T
G
G
L
Y
-----------------------EEG-------
E
-----
E
A
A
V
D
T
L
L
Y
T
R
E
E
I
E
R
I
I
R
K
A
F
E
L
A
L
T
R
K
K
K
-------------
V
T
S
V
D
K
A
N
V
L
E
-
S
S
R
L
W
R
---
E
V
A
E
E
V
A
K
E
Y
P
D
V
E
L
E
H
M
L
V
D
N
A
A
M
Q
L
I
R
N
P
R
Q
F
D
V
I
V
T
E
N
M
F
G
D
I
L
S
D
E
A
S
M
I
T
G
S
L
G
M
L
P
S
A
S
L
S
T
D
G
L
G
L
Y
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
M
L
R
Y
S
F
G
-
L
E
E
E
A
K
A
I
E
K
A
V
E
K
V
L
A
E
G
-
Y
R
T
A
---
D
I
----
A
KPG
G
K
-----
Y
----
V
--
S
----
T
T
E
M
T
D
E
V
K
A
A
V
159
HHSearch
84.18
52%
-25
- C6 -
-
1GC8
-
LEU3_THET8
B:
[1-344]
--
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
PR-
K
--
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
-
P
----------
R
G
M
S---------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
F
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
-
G
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
L
E
T
--
P
P
P
---
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
R
H
L
168
HHSearch
83.26
51%
-17
- C6 -
-
4XXV
3
LEU3_BURTA
B:
[9-363]
--
M
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
----
E
K
F
E
L
E
H
A
P
V
G
G
A
G
Y
-
E
A
S
G
H
P
L
P
D
A
T
L
-
A
L
A
K
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
--
L
ER-
A
--
L
--
R
P
-
E
-
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
-
V
A
--
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
-----
Q
-
P
----------
R
G
V
RAAPDGPFAG
E
-----
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
A
K
K
-------------
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
F
W
R
---
D
V
M
I
D
V
S
K
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
-
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
R
T
G
---
D
I
----
A
---
T
------
P
GCRQ
V
--
G
----
T
A
A
M
G
D
A
V
V
A
A
L
50
PsiBlast_CBE
82.77
48%
-26
- C6 -
-
3UDU
1
LEU3_CAMJE
F:
[8-352]
---
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
N
--
L
---
P
--
I
DQ
R
P
-
E
-
R
A
S
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
-
I
Q
K-
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
S
F
K
-
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
----
S
YL
N
----
T
D
E
M
G
D
C
I
L
---
43
PsiBlast_CBE
82.72
49%
-8
- C6 -
-
4XXV
3
LEU3_BURTA
B:
[10-363]
---
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
E
K
----
F
E
L
E
H
A
P
V
G
G
A
G
Y
-
E
A
S
G
H
P
L
P
D
A
T
L
-
A
L
A
K
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
--
L
ER-
A
--
L
--
R
P
-
E
-
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
-
V
A
--
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
-----
Q
-
P
RGVRAAPDGP
F
A
G
----------
E
-----
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
A
K
K
-------------
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
F
W
R
---
D
V
M
I
D
V
S
K
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
S
L
N
-
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
R
T
G
---
D
I
----
A
---
T
PGCR--
Q
----
V
--
G
----
T
A
A
M
G
D
A
V
V
A
A
L
167
HHSearch
82.70
51%
-13
- C6 -
-
4IWH
-
LEU3_BURTA
A:
[8-363]
-
H
M
K
I
A
V
L
P
G
D
G
I
G
P
E
I
V
N
E
A
V
K
V
L
N
A
L
D
----
E
K
F
E
L
E
H
A
P
V
G
G
A
G
Y
-
E
A
S
G
H
P
L
P
D
A
T
L
-
A
L
A
K
E
A
D
A
I
L
F
G
A
V
G
D
W
K
Y
D
S
--
L
ER-
A
--
L
--
R
P
-
E
-
Q
A
-
I
L
G
L
R
K
H
L
E
L
F
A
N
F
R
P
A
I
C
Y
P
Q
L
V
D
A
S
P
L
K
P
E
-
L
-
V
A
--
G
L
D
I
L
I
V
R
E
L
N
G
D
I
Y
F
G
-----
Q
-
P
----------
R
G
V
RAAPDGPFAG
E
-----
R
E
G
F
D
T
M
R
Y
S
E
P
E
V
R
R
I
A
H
V
A
F
Q
A
A
Q
K
R
A
K
K
-------------
L
L
S
V
D
K
S
N
V
L
E
-
T
S
Q
F
W
R
---
D
V
M
I
D
V
S
K
E
Y
A
D
V
E
L
S
H
M
Y
V
D
N
A
A
M
Q
L
A
K
A
P
K
Q
F
D
V
I
V
T
G
N
M
F
G
D
I
L
S
D
E
A
S
M
L
T
G
S
I
G
M
L
P
S
A
S
L
D
K
N
N
K
G
L
Y
E
P
S
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
L
A
T
I
L
S
A
A
M
L
L
R
Y
-
S
L
N
R
A
E
Q
A
D
R
I
E
R
A
V
K
T
V
L
E
Q
G
-
Y
R
T
G
---
D
I
----
A
---
T
------
P
GCRQ
V
--
G
----
T
A
A
M
G
D
A
V
V
A
A
L
162
HHSearch
82.57
50%
-24
- C6 -
-
1A05
2
LEU3_ACIFR
A:
[1-354]
-
M
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
-
D
A
S
D
D
P
L
P
A
A
S
L
-
Q
L
A
M
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
--
Y
PP-
A
--
K
--
R
P
-
E
-
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
-----
Q
-
P
----------
R
G
L
E
V
I
-------
D
G
K
---
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
R
K
Q
-------------
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
L
W
R
---
E
V
V
T
E
V
A
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
G
-
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
S
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
---
D
I
----
A
---
A
------
P
G
T
P
V
I
--
G
----
T
K
A
M
G
A
A
V
V
N
A
L
27
PsiBlast_CBE
82.51
51%
-19
- C6 -
-
4F7I
16
LEU3_THET8
C:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
55
PsiBlast_CBE
82.41
48%
-25
- C6 -
-
3UDU
1
LEU3_CAMJE
A:
[8-352]
---
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
N
--
L
---
P
--
I
DQ
R
P
-
E
-
R
A
S
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
-
I
Q
K-
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
S
F
K
-
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
----
S
Y
L
N
----
T
D
E
M
G
D
C
I
L
---
49
PsiBlast_CBE
82.31
48%
-25
- C6 -
-
3UDU
1
LEU3_CAMJE
G:
[8-352]
---
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
N
--
L
---
P
--
I
DQ
R
P
-
E
-
R
A
S
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
-
I
Q
K-
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
S
F
K
-
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
----
S
YL
N
----
T
D
E
M
G
D
C
I
L
---
41
PsiBlast_CBE
82.22
51%
-23
- C6 -
-
4WUO
14
LEU3_THET8
A:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
51
PsiBlast_CBE
82.15
48%
-26
- C6 -
-
3UDU
2
LEU3_CAMJE
E:
[8-352]
---
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
N
--
L
---
P
--
I
DQ
R
P
-
E
-
R
A
S
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
-
I
Q
K-
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
S
F
K
-
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
----
S
YL
N
----
T
D
E
M
G
D
C
I
L
---
172
HHSearch
82.13
48%
-26
- C6 -
-
3UDU
-
LEU3_CAMJE
H:
[6-355]
-
T
Y
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
---
L
PI-
D
--
Q
--
R
P
E
R
-
A
S
-
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
I
Q
K
--
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
-
S
F
K
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
SY--
L
--
N
----
T
D
E
M
G
D
C
I
L
E
I
L
171
HHSearch
82.04
48%
-24
- C6 -
-
3UDU
1
LEU3_CAMJE
A:
[5-355]
K
T
Y
K
V
A
V
L
A
G
D
G
I
G
P
L
V
M
K
E
A
L
K
I
L
T
F
I
A
Q
K
Y
N
F
S
F
E
L
N
E
A
K
I
G
G
A
S
I
-
D
A
Y
G
V
A
L
S
D
E
T
L
-
K
L
C
E
Q
S
D
A
I
L
F
G
S
V
G
G
P
K
W
D
N
--
L
PI-
D
--
Q
--
R
P
E
R
-
A
S
-
L
L
P
L
R
K
H
F
N
L
F
A
N
L
R
P
C
K
I
Y
E
S
L
T
H
A
S
P
L
K
N
E
-
I
I
Q
K
--
G
V
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
Q
----------
D
L
G
----------
K
-----
E
S
A
Y
D
T
E
I
Y
T
K
K
E
I
E
R
I
A
R
I
A
F
E
S
A
R
I
R
K
K
K
-------------
V
H
L
I
D
K
A
N
V
L
A
-
S
S
I
L
W
R
---
E
V
V
A
N
V
A
K
D
Y
Q
D
I
N
L
E
Y
M
Y
V
D
N
A
A
M
Q
I
V
K
N
P
S
I
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
L
A
A
I
N
G
S
L
G
L
L
S
S
A
S
L
N
D
K
G
F
G
L
Y
E
P
A
G
G
S
A
P
D
I
A
H
L
N
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
K
Y
-
S
F
K
E
E
Q
A
A
Q
D
I
E
N
A
I
S
L
A
L
A
Q
G
-
K
M
T
K
---
D
L
----
N
---
A
------
K
S
Y
--
L
--
N
----
T
D
E
M
G
D
C
I
L
E
I
L
5
PsiBlast_PDB
82.01
51%
-20
- C6 -
-
1XAC
-
LEU3_THET8
A:
[2-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
Q
--
N
---
P
RE
L
--
R
P
-
E
-
K
G
-
L
L
S
I
R
K
Q
L
D
L
F
A
N
L
R
P
V
K
V
F
E
S
L
S
D
A
S
P
L
K
K
E
-
Y
-
I
D
--
N
V
D
F
V
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
R
H
L
32
PsiBlast_CBE
81.98
51%
-20
- C6 -
-
2Y42
4
LEU3_THET8
B:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
47
PsiBlast_CBE
81.92
48%
-22
- C6 -
-
1A05
2
LEU3_ACIFR
B:
[2-354]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
-
D
A
S
D
D
P
L
P
A
A
S
L
-
Q
L
A
M
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
--
Y
PP-
A
--
K
--
R
P
-
E
-
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
QPRGL
E
-
V
----------
I
D
G
----------
K
-----
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
R
K
Q
-------------
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
L
W
R
---
E
V
V
T
E
V
A
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
S
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
---
D
I
----
A
---
A
------
P
----
G
--
T
PVIG
T
K
A
M
G
A
A
V
V
N
A
L
40
PsiBlast_CBE
81.87
51%
-20
- C6 -
-
4WUO
7
LEU3_THET8
B:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
A
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
156
HHSearch
81.82
51%
-21
- C6 -
-
2Y3Z
7
LEU3_THET8
A:
[3-347]
-
S
M
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
PR-
K
--
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
-
P
----------
R
G
M
S
---------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
-
T
P
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
L
A
R
K
V
E
D
A
V
A
K
A
L
L
E
T
--
P
P
P
---
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
R
H
L
48
PsiBlast_CBE
81.56
48%
-23
- C6 -
-
1A05
2
LEU3_ACIFR
A:
[2-354]
--
K
K
I
A
I
F
A
G
D
G
I
G
P
E
I
V
A
A
A
R
Q
V
L
D
A
V
D
Q
A
A
H
L
G
L
R
C
T
E
G
L
V
G
G
A
A
L
-
D
A
S
D
D
P
L
P
A
A
S
L
-
Q
L
A
M
A
A
D
A
V
I
L
G
A
V
G
G
P
R
W
D
A
--
Y
PP-
A
--
K
--
R
P
-
E
-
Q
G
-
L
L
R
L
R
K
G
L
D
L
Y
A
N
L
R
P
A
Q
I
F
P
Q
L
L
D
A
S
P
L
R
P
E
-
L
-
V
R
--
D
V
D
I
L
V
V
R
E
L
T
G
D
I
Y
F
G
QP
R
G
L
E
-
V
----------
I
D
G
----------
K
-----
R
R
G
F
N
T
M
V
Y
D
E
D
E
I
R
R
I
A
H
V
A
F
R
A
A
Q
G
R
R
K
Q
-------------
L
C
S
V
D
K
A
N
V
L
E
-
T
T
R
L
W
R
---
E
V
V
T
E
V
A
R
D
Y
P
D
V
R
L
S
H
M
Y
V
D
N
A
A
M
Q
L
I
R
A
P
A
Q
F
D
V
L
L
T
G
N
M
F
G
D
I
L
S
D
E
A
S
Q
L
T
G
S
I
G
M
L
P
S
A
S
L
G
E
-
G
R
A
M
Y
E
P
I
H
G
S
A
P
D
I
A
G
Q
D
K
A
N
P
L
A
T
I
L
S
V
A
M
M
L
R
H
S
L
N
-
A
E
P
W
A
Q
R
V
E
A
A
V
Q
R
V
L
D
Q
G
-
L
R
T
A
---
D
I
----
A
---
A
------
P
----
G
--
T
P
V
I
G
T
K
A
M
G
A
A
V
V
N
A
L
16
PsiBlast_PDB
81.19
51%
-21
- C6 -
-
2ZTW
2
LEU3_THET8
A:
[2-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
R
H
L
35
PsiBlast_CBE
81.13
51%
-22
- C6 -
-
2Y41
2
LEU3_THET8
A:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
38
PsiBlast_CBE
80.58
51%
-22
- C6 -
-
2Y3Z
7
LEU3_THET8
A:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
169
HHSearch
80.04
44%
-10
- C6 -
-
3VMK
2
?
B:
[13-371]
-
S
Y
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
--
L
PPN
D
--
Q
--
P
E
-
R
-
G
A
-
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
-
I
S
E
K
--
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
-----
K
-
P
----------
K
G
R
Q
G
E
G
E-----
N
-----
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
E
V
V
E
E
V
A
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
---
E
L
----
L
---
P
ASERSQ
A
----
K
--
S
----
T
S
Q
M
G
D
Y
I
A
Q
A
I
34
PsiBlast_CBE
79.61
51%
-23
- C6 -
-
2Y41
2
LEU3_THET8
B:
[5-344]
---
K
V
A
V
L
P
G
D
G
I
G
P
E
V
T
E
A
A
L
K
V
L
R
A
L
D
E
A
E
G
L
G
L
A
Y
E
V
F
P
F
G
G
A
A
I
-
D
A
F
G
E
P
F
P
E
P
T
R
-
K
G
V
E
E
A
E
A
V
L
L
G
S
V
G
G
P
K
W
D
G
--
L
---
P
RK
I
--
R
P
-
E
-
T
G
-
L
L
S
L
R
K
S
Q
D
L
F
A
N
L
R
P
A
K
V
F
P
G
L
E
R
L
S
P
L
K
E
E
-
I
-
A
R
--
G
V
D
V
L
I
V
R
E
L
T
G
G
I
Y
F
G
-----
E
P
R
----------
G
M
S
----------
E
-----
A
E
A
W
N
T
E
R
Y
S
K
P
E
V
E
R
V
A
R
V
A
F
E
A
A
R
K
R
R
K
H
-------------
V
V
S
V
D
K
A
N
V
L
E
-
V
G
E
F
W
R
---
K
T
V
E
E
V
G
R
G
Y
P
D
V
A
L
E
H
Q
Y
V
D
A
M
A
M
H
L
V
R
S
P
A
R
F
D
V
V
V
T
G
N
I
F
G
D
I
L
S
D
L
A
S
V
L
P
G
S
L
G
L
L
P
S
A
S
L
G
R
G
T
P
-
V
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
T
A
A
I
L
S
A
A
M
M
L
E
H
A
F
G
-
L
V
E
----
L
A
R
K
V
E
D
A
V
A
K
A
-
L
L
E
T
PPP
D
L
----
G
---
G
------
S
----
A
--
G
----
T
E
A
F
T
A
T
V
L
---
66
PsiBlast_CBE
77.40
48%
-11
- C6 -
-
3WZX
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
57
PsiBlast_CBE
77.05
48%
-11
- C6 -
-
3WZV
1
?
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
90
PsiBlast_CBE
77.00
45%
-14
- C6 -
-
3VMK
2
?
B:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
--
L
---
P
--
P
ND
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
---
I
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
N
-----
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
E
V
V
E
E
V
A
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
---
E
L
----------------------------------------
58
PsiBlast_CBE
76.91
48%
-14
- C6 -
-
3VMJ
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
65
PsiBlast_CBE
76.89
48%
-14
- C6 -
-
3WZY
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
91
PsiBlast_CBE
76.88
45%
-15
- C6 -
-
3VMK
2
?
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
A
A
V
E
K
R
F
D
L
S
I
E
Y
S
E
Y
D
V
G
G
A
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
--
L
---
P
--
P
ND
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
---
I
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
N
-----
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
E
V
V
E
E
V
A
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
S
D
G
-
Y
L
T
C
---
E
L
----------------------------------------
89
PsiBlast_CBE
76.70
45%
-17
- C6 -
-
3VML
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
V
L
F
G
S
V
G
G
P
K
W
E
H
--
L
---
P
--
P
ND
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
M
R
P
A
K
L
H
P
G
L
E
H
M
S
P
L
R
S
D
---
I
S
E
K
G
F
D
I
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
N
-----
E
E
A
F
D
T
M
R
Y
S
R
K
E
I
R
R
I
A
K
I
A
F
E
S
A
Q
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
E
V
V
E
E
V
A
K
D
Y
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
N
E
F
D
V
M
L
C
S
N
L
F
G
D
I
V
S
D
E
I
A
M
L
T
G
S
M
G
L
L
A
S
I
S
M
N
S
Q
G
F
G
M
Y
E
P
A
G
G
S
A
P
D
I
A
G
Q
G
I
A
N
P
V
A
Q
I
L
S
A
A
L
L
L
R
H
S
L
K
-
L
E
D
A
A
L
A
I
E
A
A
V
S
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
64
PsiBlast_CBE
76.50
48%
-10
- C6 -
-
3VKZ
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
63
PsiBlast_CBE
76.48
48%
-10
- C6 -
-
3VL2
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
59
PsiBlast_CBE
76.46
48%
-12
- C6 -
-
3VL7
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
62
PsiBlast_CBE
76.20
48%
-11
- C6 -
-
3VL3
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
56
PsiBlast_CBE
76.03
48%
-12
- C6 -
-
3WZW
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
60
PsiBlast_CBE
75.93
48%
-12
- C6 -
-
3VL6
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
61
PsiBlast_CBE
75.51
48%
-14
- C6 -
-
3VL4
1
LEU3_SHEON
A:
[15-348]
---
Q
I
A
V
L
A
G
D
G
I
G
P
E
V
M
A
E
A
R
K
V
L
K
A
V
E
A
R
F
G
L
N
I
E
Y
T
E
Y
D
V
G
G
I
A
I
-
D
N
H
G
C
P
L
P
E
A
T
L
-
K
G
C
E
A
A
D
A
I
L
F
G
S
V
G
G
P
K
W
E
K
--
L
---
P
--
P
NE
Q
P
-
E
-
R
G
A
L
L
P
L
R
G
H
F
E
L
F
C
N
L
R
P
A
K
L
H
D
G
L
E
H
M
S
P
L
R
S
D
I
S
-
A
R
--
G
F
D
V
L
C
V
R
E
L
T
G
G
I
Y
F
G
KP
K
G
R
Q
-
G
----------
E
G
E
----------
S
-----
E
E
A
F
D
T
M
R
Y
S
R
R
E
I
S
R
I
A
R
I
A
F
E
A
A
R
G
R
R
K
K
-------------
V
T
S
V
D
K
A
N
V
L
A
-
C
S
V
L
W
R
---
Q
V
V
E
E
V
A
V
D
F
P
D
V
E
L
E
H
I
Y
I
D
N
A
T
M
Q
L
L
R
R
P
D
E
F
D
V
M
L
C
S
N
L
F
G
D
I
L
S
D
E
I
A
M
L
T
G
S
M
G
L
L
S
S
A
S
M
N
S
T
G
F
G
L
F
E
P
A
G
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
A
Q
I
L
S
A
A
L
M
L
R
H
S
L
K
-
Q
E
E
A
A
S
A
I
E
R
A
V
T
K
A
L
N
S
G
-
Y
L
T
G
---
E
L
----------------------------------------
93
PsiBlast_CBE
71.73
37%
-24
- C6 -
-
5HN6
2
?
A:
[3-319]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
Y
-----
E
G
G
V
D
V
F
Q
E
C
G
S
P
I
R
E
E
D
L
-
E
E
I
R
R
S
D
A
V
L
F
G
A
T
T
T
P
-
F
D
L
--
P
---
G
--
Y
--
R
S
-
L
----
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
I
I
-------------
P
D
-
L
-
R
T
--
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
-----
I
-
G
----------
A
V
V
----------
N
-----
G
R
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
G
S
F
-------------
I
T
F
V
H
K
A
N
V
L
T
-
G
D
K
F
F
R
---
R
I
V
R
E
V
A
G
E
-
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
-
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
-
D
Y
L
G
-
L
--
D
G
S
L
I
R
A
A
V
R
G
Y
V
V
N
G
-
E
L
T
P
---
D
M
----
G
---
G
------
R
----
A
--
R
----
T
E
D
V
V
R
G
I
I
G
E
I
95
PsiBlast_CBE
71.55
37%
-21
- C6 -
-
5HN4
3
?
A:
[3-319]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
Y
-----
E
G
G
V
D
V
F
Q
E
C
G
S
P
I
R
E
E
D
L
-
E
E
I
R
R
S
D
A
V
L
F
G
A
T
T
T
P
-
F
D
L
--
P
---
G
--
Y
--
R
S
-
L
----
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
I
I
-------------
P
D
-
L
-
R
T
--
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
-----
I
-
G
----------
A
V
V
----------
N
-----
G
R
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
G
S
F
-------------
I
T
F
V
H
K
A
N
V
L
T
-
G
D
K
F
F
R
---
R
I
V
R
E
V
A
G
E
-
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
-
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
-
D
Y
L
G
-
L
--
D
G
S
L
I
R
A
A
V
R
G
Y
V
V
N
G
-
E
L
T
P
---
D
M
----
G
---
G
------
R
----
A
--
R
----
T
E
D
V
V
R
G
I
I
G
E
I
94
PsiBlast_CBE
71.03
37%
-24
- C6 -
-
5HN5
2
?
A:
[3-319]
---
R
V
A
V
I
P
G
D
G
I
G
P
E
V
I
D
G
A
V
R
V
L
K
A
V
T
G
R
V
R
F
E
Y
Y
-----
E
G
G
V
D
V
F
Q
E
C
G
S
P
I
R
E
E
D
L
-
E
E
I
R
R
S
D
A
V
L
F
G
A
T
T
T
P
-
F
D
L
--
P
---
G
--
Y
--
R
S
-
L
----
I
L
T
L
R
K
E
L
G
L
Y
A
N
L
R
I
I
-------------
P
D
-
L
-
R
T
--
G
R
E
I
V
I
V
R
E
N
S
E
G
L
Y
F
G
-----
I
-
G
----------
A
V
V
----------
N
-----
G
R
A
V
D
V
R
L
I
T
R
E
G
A
E
R
I
A
R
F
A
V
E
Q
A
K
A
R
G
S
F
-------------
I
T
F
V
H
K
A
N
V
L
T
-
G
D
K
F
F
R
---
R
I
V
R
E
V
A
G
E
-
E
G
V
E
V
R
D
A
I
I
D
S
F
T
I
K
L
V
R
N
P
W
E
H
G
V
I
L
S
E
N
L
F
G
D
I
L
S
D
L
A
T
V
H
A
G
S
I
G
I
V
P
S
G
N
Y
G
-
D
G
I
A
L
F
E
P
V
H
G
S
A
P
D
I
A
G
K
G
I
A
N
P
I
G
A
I
L
S
G
A
M
L
L
-
D
Y
L
G
-
L
--
D
G
S
L
I
R
A
A
V
R
G
Y
V
V
N
G
-
E
L
T
P
---
D
M
----
G
---
G
------
R
----
A
--
R
----
T
E
D
V
V
R
G
I
I
G
E
I
115
PsiBlast_CBE
67.40
35%
-3
- C6 -
-
3TY4
7
LYS12_SCHPO
B:
[19-364]
----------
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
-
E
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
--
A
---
G
--
Y
-----
S
-
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
K
G
----
K
P
---------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-----
E
-
E
----------
R
M
V
----------
Q
NTPG
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
N
F
-
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
-
E
F
M
G
-
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
---
D
L
----
G
---
G
------
K
----
S
--
G
----
T
N
E
I
T
D
A
V
L
A
N
I
118
PsiBlast_CBE
66.93
35%
-5
- C6 -
-
3TY3
4
LYS12_SCHPO
A:
[19-364]
----------
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
-
E
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
--
A
---
G
--
Y
-----
S
-
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
K
G
----
K
P
---------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-----
E
-
E
----------
R
M
V
----------
Q
NTPG
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
G
T
Y
S
IHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
N
F
-
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
-
E
F
M
G
-
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
---
D
L
----
G
---
G
------
K
----
S
--
G
----
T
N
E
I
T
D
A
V
L
A
N
I
116
PsiBlast_CBE
66.54
35%
-3
- C6 -
-
3TY4
5
LYS12_SCHPO
A:
[19-364]
----------
D
G
I
G
K
E
V
V
P
A
A
R
R
L
M
E
N
L
P
A
K
H
K
L
K
F
D
F
I
D
L
D
A
G
W
G
T
F
-
E
R
T
G
K
A
L
P
E
R
T
V
E
R
L
K
T
E
C
N
A
A
L
F
G
A
V
Q
S
P
T
H
K
V
--
A
---
G
--
Y
-----
S
-
S
P
-
I
V
A
L
R
K
K
M
G
L
Y
A
N
V
R
P
V
K
S
L
D
G
A
K
G
----
K
P
---------
V
D
L
V
I
V
R
E
N
T
E
C
L
Y
V
K
-----
E
-
E
----------
R
M
V
----------
Q
NTPG
K
R
V
A
E
A
I
R
R
I
S
E
E
A
S
T
K
I
G
K
M
A
F
E
I
A
K
S
R
Q
K
I
R
E
S
GTYSIHK
K
P
L
V
T
I
I
H
K
S
N
V
M
S
V
T
D
G
L
F
R
E
S
C
R
H
A
Q
S
L
D
P
S
Y
A
S
I
N
V
D
E
Q
I
V
D
S
M
V
Y
R
L
F
R
E
P
E
C
F
D
V
V
V
A
P
N
L
Y
G
D
I
L
S
D
G
A
A
S
L
I
G
S
L
G
L
V
P
S
A
N
V
G
D
N
F
-
V
M
S
E
P
V
H
G
S
A
P
D
I
A
G
R
G
I
A
N
P
V
A
T
F
R
S
V
A
L
M
L
-
E
F
M
G
-
H
Q
D
A
A
A
D
I
Y
T
A
V
D
K
V
L
T
E
G
K
V
L
T
P
---
D
L
----
G
---
G
------
K
----
S
--
G
----
T
N
E
I
T
D
A
V
L
A
N
I