@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1203: (2018-01-07 )
MNYLKFIKKTKLILMGILIFLSSFNGVLLSGIIVYAGSLNQTSSFSDVLRFGAISILGWSAIYISNYYLEVTEASITKDINVKIKQGYFREQYLFSEMVKDYSSIISVLSNDLRLIEENYFRQIFEIISSILLFIVSLSFMLYLNFLVSIIFIVLSALPIIVPVFMKKMLSNSANEYSNSNAEYTHIIKEIFNGFKTLKSYSVTKEIISLSDKKLDKLEDSTFNLKRSEVLSKLVAVLISGFCFLVPLVVGCYFVIYHKSLSFSELIGIFLANDKVLGPIQSIAYSLNKINTTKDLRKPFLKYLSGEKNFVDAEHDNNGLYTSSIDEIHMKDVVYSITPENKLSIDFSFKSPFRVLLTGTSGSGKTTILNLINGSLKPQKGYVNLLSHGKKSSDSIPTVDQTPYIFDTTIRENVTLFQNEYFSDDQIIEVLKKVNLYEELEKIDILNYQCGENGSNLSGGQKQKIALARALIRNNKVYLFDEISANLDNDNSNSIHDILFNLGISFIEVSHHYDLNDKRYTDIYKLENGTLFKIK
Atome Classification :
(20 SA)
.........10........20........30........40....----..------.----.50......-----..60........70........80........90---.....----...100----.........110.......120.-------------......130.......140........150......--.160.......170.......180.......190.......200.......210.......220.......230........240.......250......-----.260----------------.......270----....---....-280.......290-----........---300.......310.......320.......330.......340.....----....350.--......360.......370.......380.....-------..390------.......400.......410.......420-........430.......440.-.-.....450.........460.......470.......480.......490.......--500---..-.....510.....-..520.......530...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
Y
L
K
F
I
K
K
T
K
L
I
L
M
G
I
L
I
F
L
S
SF
N
G
V
L
L
S
G
I
I
V
YAGSLNQTS
S
F
----
S
D
------
V
----
L
R
F
G
A
I
S
I
L
-----
G
W
S
A
I
Y
I
S
N
Y
Y
L
E
VTEASITK
D
I
N
V
K
I
KQG
Y
F
R
E
---
Q
Y
L
F
S
----
E
M
V
K
------
D
Y
S
S
I
I
S
V
L
S
N
D
L
R
L
I
E
E
N
Y
F
R
Q
-------------
I
F
E
I
I
S
S
I
L
L
F
I
V
S
L
S
F
M
-
L
Y
L
N
F
L
V
S
I
I
F
I
V
L
S
A
L
--
P
I
I
V
P
V
F
M
K
K
M
L
SNSANEYSNSN
A
E
Y
T
H
I
I
K
E
I
F
N
G
F
K
T
L
K
S
Y
S
V
T
K
E
I
I
S
L
S
D
K
K
L
D
K
LEDSTFNL
K
R
S
E
V
-
L
S
K
L
V
A
V
L
I
S
G
F
C
F
L
V
P
L
V
V
G
C
Y
F
V
I
YH-----KSL
S
----------------
F
S
E
L
I
G
I
F
L-----ANDK---VL
G
P
-
I
Q
S
I
A
Y
S
L
NKIN------T
T
K
D
L
R
K
P
---
F
L
K
Y
LSGEKNFVDAEHDNNG
L
Y
TSS
I
D
E
I
H
M
K
D
V
V
Y
S
ITPE--
N
K
L
S
I
----
D
F
SFKS
P
F
--
R
V
L
L
TGTSGSG
K
T
T
I
L
N
L
INGSLKPQK
G
Y
V
N
L
L
S-------HGKKS------SDSIPTVDQT
P
Y
I
F
DTTIRE
N
V
T
L
F
Q
NEY--F
S
D
D
Q
I
I
E
V
L
K
K
V
N
L
Y
E
E
L
E
KI-
D
-
I
L
N
Y
QC--GENGSNLSGG
Q
K
Q
K
I
A
L
A
R
A
L
IRNN
K
V
Y
L
F
DEISANLDNDNS
N
S
I
H
D
I
L
--
F
NL---GI-
S
F
I
E
V
S
HHYDLND-K
R
Y
T
D
I
Y
KLEN
G
T
L
F
K
IK
121
HHSearch
78.26
18%
-47
* C4 *
-
5MKK
-
?
B:
[23-551]
-----------
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
A
V
Q
A
G
R
------
G
------
F
----
G
V
Y
A
L
A
I
V
A
-----
S
A
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
-
H
---
H
L
L
T
L
D
R
D
F
Y
H
K
H
------
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
M
V
G
P
G
-------------
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
-
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
--
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
-
P
L
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
V
V
R
G
-----
E
-
L
S
----------------
V
G
E
L
V
Q
F
N
A
-----
Y
L
A
Q
---
L
T
W
P
-
I
L
G
L
G
W
V
M
A
L
Y
Q
------
R
G
L
T
S
L
R
R
---
L
F
E
L
L
D
E
K
P
A
I
R
D
E
D
P
-
L
P
L
A
L
E
D
L
S
G
E
V
R
F
E
G
V
G
L
K
R
D
G
---
R
W
L
L
R
----
G
L
T
L
T
I
P
E
GM
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
-
V
Y
V
G
GHEARRI
P
L
A
V
L
------
R
K
A
V
G
V
A
P
Q
E
P
F
L
F
S
E
T
I
L
E
N
I
A
F
G
L
D
-
E
--
V
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
-
G
Y
E
T
V
L
--
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
I
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
--
K
T
V
L
--
G
K
Q
T
T
L
L
I
S
H
R
T
A
--
A
L
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
--
1
PsiBlast_PDB
75.31
27%
-
- C3 -
-
4RY2
-
?
A:
[160-680]
-
G
F
L
K
P
L
K
K
T
V
L
C
-----
I
F
L
A
S
----
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
----
D
D
------
L
----
I
K
F
E
K
L
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
---
Y
Y
--
S
----
H
V
L
K
LPM
N
F
F
N
S
R
K
V
G
E
I
I
S
---
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
------
F
F
I
S
F
I
I
I
L
L
Y
G
----
I
I
V
T
V
F
-
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
-
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
NMS
G
G
Q
L
L
A
----------------
F
N
A
L
L
A
Y
F
L
-----
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
LA
T
E
K
E
L
------------
G
D
I
E
F
R
N
V
D
F
-
R
Y
G
L
R
K
P
V
L
K
N
I
N
L
T
------
I
P
K
--
G
K
-----------------
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
-------
H
S
I
K
N
IS
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
N
E
N
--
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
-
P
--
L
K
Y
D
T
FL
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
--
Y
G
L
ED-
D
V
-
T
V
I
I
I
A
H
R
------------------------
20
PsiBlast_PDB
73.29
24%
0
- C- -
-
4Q9I
-
MDR1A_MOUSE
A:
[142-658]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
19
PsiBlast_PDB
73.29
24%
0
- C- -
-
4Q9H
-
MDR1A_MOUSE
A:
[142-655]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
18
PsiBlast_PDB
73.29
24%
0
- C- -
-
4M2T
-
MDR1A_MOUSE
A:
[142-647]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
VGQA
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LKG
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
17
PsiBlast_PDB
73.29
24%
0
- C- -
-
4M2S
-
MDR1A_MOUSE
A:
[142-647]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LKG
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
16
PsiBlast_PDB
73.29
24%
0
- C- -
-
4KSD
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
ISKEYSIG
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
15
PsiBlast_PDB
73.29
24%
0
- C- -
-
4KSC
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
ISKEYSIG
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
14
PsiBlast_PDB
73.29
24%
0
- C- -
-
4KSB
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
ISKEYSIG
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
13
PsiBlast_PDB
73.29
24%
0
- C- -
-
5KPI
-
MDR1A_MOUSE
A:
[142-653]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
VGQA
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LKG
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
12
PsiBlast_PDB
73.29
24%
0
- C- -
-
3G61
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
K
EYSIGQ
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
11
PsiBlast_PDB
73.29
24%
0
- C- -
-
3G60
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYSIGQV
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
10
PsiBlast_PDB
73.29
24%
0
- C- -
-
5KPJ
-
MDR1A_MOUSE
A:
[142-657]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
KEYS
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
9
PsiBlast_PDB
73.29
24%
0
- C- -
-
4LSG
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
ISKEYSIGQV
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
8
PsiBlast_PDB
73.29
24%
0
- C- -
-
3G5U
-
MDR1A_MOUSE
A:
[142-650]
-----------------------------------------------------------------------------------------------------
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
----
F
D
V
H
------
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
-------------
I
G
M
F
F
Q
A
M
A
T
F
F
G
G
F
I
I
G
-
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
--
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
-------
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
-
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
--
L
I
Y
A
S
Y
A
L
A
F
W
-----
Y
G
T
S
L
V
I
S
K
EYSIGQVLTV
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
---
A
F
A
N
-
A
R
G
A
A
Y
E
V
F
K
I
I
------
D
N
K
P
S
I
D
S
---
F
S
K
--
S
G
H
K
P
--
D
N
I
Q
G
N
----------
L
E
F
K
N
I
H
F
S
Y
P
S
R
--
K
E
V
Q
I
LK
G
L
N
L
K
V
K
S
G
Q
--
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
-------
Q
D
I
R
T
IN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
-
Y
G
R
E
D
--
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
-
P
H
Q
F
D
T
L
V
--
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
---
G
R
-
T
T
I
V
I
A
H
R
--
L
S
T
-
V
R
N
A
D
V
------------
118
HHSearch
70.36
20%
-35
- C4 -
-
4AYX
6
ABCBA_HUMAN
A:
[14-561]
---
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
VDY
S
D
N
------
L
----
T
R
L
C
L
G
L
S
A
-----
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
-
S
---
S
I
L
R
Q
E
V
A
F
F
D
K
T
------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
-------------
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
-
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-----
H
-
M
T
----------------
V
G
E
L
S
S
F
L
M
-----
Y
A
F
W
---
V
G
I
S
-
I
G
G
L
S
S
F
Y
S
E
L
M
------
K
G
L
G
A
G
G
R
---
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-
V
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
PE
V
P
I
F
Q
----
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
-
I
S
L
D
GHDIRQL
N
P
V
W
L
------
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
SS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
-
G
F
N
T
V
V
--
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
--
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
--
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
--
135
HHSearch
69.07
16%
-27
- C4 -
-
4MRS
6
ATM1_NOVAD
B:
[37-575]
---------
R
R
V
V
G
A
I
L
M
V
L
L
G
K
A
T
T
L
A
L
P
F
A
Y
K
K
A
V
D
A
M
T
L
G
G
G
A---
Q
P
------
A
L
T
V
A
L
A
F
V
L
A
Y
A
L
-----
G
R
F
S
G
V
L
F
D
N
L
R
N
I
V
F
E
R
V
G
Q
D
A
T
R
H
L
A
E
N
V
F
-
A
---
R
L
H
K
L
SLRF
H
L
A
R
------
R
T
G
E
V
T
K
V
I
E
R
G
T
K
S
I
D
T
M
L
Y
F
L
-------------
L
F
N
I
A
P
T
V
I
E
L
T
A
V
I
-
V
I
-
F
W
L
N
F
G
L
G
L
V
T
A
T
I
L
A
V
I
A
Y
V
W
T
T
R
T
I
T
E
W
R
T
H
L
R
E
K
M
N
R
L
D
G
Q
A
L
A
R
A
V
D
S
L
L
N
Y
E
T
V
K
Y
F
G
A
E
S
R
E
E
A
R
Y
A
S
A
A
R
A
Y
A
D
A
A
V
K
S
E
N
S
L
G
-
L
L
N
I
A
Q
A
L
I
V
N
L
L
M
A
G
A
M
A
W
T
V
Y
G
W
S
Q
G
-----
K
-
L
T
----------------
V
G
D
L
V
F
V
N
T
-----
Y
L
T
Q
---
L
F
R
P
-
L
D
M
L
G
M
V
Y
R
T
I
R
------
Q
G
L
I
D
M
A
E
---
M
F
R
L
I
D
T
H
I
E
V
A
D
V
P
--
N
A
P
A
L
V
V
N
R
P
S
V
T
F
D
N
V
V
F
G
Y
D
R
D
--
R
E
I
L
H
----
G
L
S
F
E
V
A
A
G
S
R
V
A
I
V
G
P
S
G
A
G
K
S
T
I
A
R
L
L
F
R
F
Y
D
P
W
E
G
R
-
I
L
I
D
GQDIAHV
T
Q
T
S
L
------
R
A
A
L
G
I
V
P
Q
D
S
V
L
F
N
D
T
I
G
Y
N
I
A
Y
G
R
D
-
G
--
A
S
R
A
E
V
D
A
A
A
K
G
A
A
I
A
D
F
I
A
R
L
P
Q
-
G
Y
D
T
E
V
--
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
L
V
K
N
P
P
I
L
L
F
D
E
A
T
S
A
L
D
T
R
T
E
Q
D
I
L
S
T
M
--
R
A
V
A
--
S
H
R
T
T
I
S
I
A
H
R
L
S
--
T
I
A
D
S
D
T
I
L
V
L
D
Q
G
R
L
A
E
--
117
HHSearch
68.80
20%
-35
- C4 -
-
4AYT
7
ABCBA_HUMAN
A:
[14-561]
---
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
T
VDY
S
D
N
------
L
----
T
R
L
C
L
G
L
S
A
-----
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
-
S
---
S
I
L
R
Q
E
V
A
F
F
D
K
T
------
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
-------------
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
-
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
--
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
-
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
A
-----
H
-
M
T
----------------
V
G
E
L
S
S
F
L
M
-----
Y
A
F
W
---
V
G
I
S
-
I
G
G
L
S
S
F
Y
S
E
L
M
------
K
G
L
G
A
G
G
R
---
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-
V
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
PE
V
P
I
F
Q
----
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
-
I
S
L
D
GHDIRQL
N
P
V
W
L
------
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
SS
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
-
G
F
N
T
V
V
--
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
--
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
--
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
--
2
PsiBlast_PDB
67.83
27%
-3
- C3 -
-
4S0F
2
?
A:
[163-683]
-
G
F
L
K
P
L
K
K
T
V
L
C
-----
I
F
L
A
S
----
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
----
D
D
------
L
----
I
K
F
E
K
L
N
D
L
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
---
Y
Y
--
S
----
H
V
L
K
LP
M
N
F
F
N
S
R
K
V
G
E
I
I
S
---
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
------
F
F
I
S
F
I
I
I
L
L
Y
G
----
I
I
V
T
V
F
-
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
I
N
L
S
S
L
T
G
I
-
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
K
G
NMS
G
G
Q
L
L
A
----------------
F
N
A
L
L
A
Y
F
L
-----
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
E
D
SDD
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
-
R
Y
G
L
R
K
P
V
L
K
N
I
N
L
T
------
I
P
K
--
G
K
-----------------
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
-------
H
S
I
K
N
IS
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
-
G
N
E
N
--
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
-
P
--
L
K
Y
D
T
FL
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
--
Y
G
L
ED-
D
V
-
T
V
I
I
I
A
H
R
------------------------
128
HHSearch
66.77
18%
2
- C4 -
-
4MYC
-
ATM1_YEAST
C:
[111-652]
-----------
V
L
I
A
L
G
L
L
I
S
A
K
I
L
N
V
Q
V
P
F
F
F
K
Q
T
I
D
S
M
N
I
A
W
D
D---
P
T
VALPAA
I
----
G
L
T
I
L
C
Y
G
V
-----
A
R
F
G
S
V
L
F
G
E
L
R
N
A
V
F
A
K
V
A
Q
N
A
I
R
T
V
S
L
Q
T
F
-
Q
---
H
L
M
K
L
DLGW
H
L
S
R
------
Q
T
G
G
L
T
R
A
M
D
R
G
T
K
G
I
S
Q
V
L
T
A
M
-------------
V
F
H
I
I
P
I
S
F
E
I
S
V
V
C
G
I
L
T
Y
Q
F
G
A
S
F
A
A
I
T
F
S
T
M
L
L
--
Y
S
I
F
T
I
K
T
T
A
W
R
T
H
F
R
R
D
A
N
K
A
D
N
K
A
A
S
V
A
L
D
S
L
I
N
F
E
A
V
K
Y
F
N
N
E
K
Y
L
A
D
K
Y
N
G
S
L
M
N
Y
R
D
S
Q
I
K
V
S
Q
S
L
A
-
F
L
N
S
G
Q
N
L
I
F
T
T
A
L
T
A
M
M
Y
M
G
C
T
G
V
I
G
G
-----
N
-
L
T
----------------
V
G
D
L
V
L
I
N
Q
-----
L
V
F
Q
---
L
S
V
P
-
L
N
F
L
G
S
V
Y
R
D
L
K
------
Q
S
L
I
D
M
E
T
---
L
F
K
L
R
K
N
E
V
K
I
K
N
A
E
R
-
P
L
M
L
P
E
N
V
P
Y
D
I
T
F
E
N
V
T
F
G
Y
H
P
D
--
R
K
I
L
K
----
N
A
S
F
T
I
P
A
GW
K
T
A
I
V
G
S
S
G
S
G
K
S
T
I
L
K
L
V
F
R
F
Y
D
P
E
S
G
R
-
I
L
I
N
GRDIKEY
D
I
D
A
L
------
R
K
V
I
G
V
V
P
Q
D
T
P
L
F
N
D
T
I
W
E
N
V
K
F
G
R
I
-
D
--
A
T
D
E
E
V
I
T
V
V
E
K
A
Q
L
A
P
L
I
K
K
L
P
Q
-
G
F
D
T
I
V
--
G
E
R
G
L
M
I
S
G
G
E
K
Q
R
L
A
I
A
R
V
L
L
K
N
A
R
I
M
F
F
D
E
A
T
S
A
L
D
T
H
T
E
Q
A
L
L
R
T
I
--
R
D
N
FTS
G
S
R
T
S
V
Y
I
A
H
R
L
R
--
T
I
A
D
A
D
K
I
I
V
L
D
N
G
R
V
R
E
--