@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1310: (2018-01-09 )
MSAIERITKAAHLIDMNDIIREGNPTLRTVAEEVTFPLSDQEIILGEKMMQFLKHSQDPVMAEKMGLRGGVGLAAPQLDISKRIIAVLVPNIVEEGETPQEAYDLEAIMYNPKIVSHSVQDAALGEGEGCLSVDRNVPGYVVRHARVTVDYFDKDGEKHRIKLKGYNSIVVQHEIDHINGIMFYDRINEKDPFAVKDGLLILE
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90...-...-..100.......110.......120-........130....-...140-.........150.......160.......170.......180.......190.......200.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
A
I
E
R
I
T
K
A
A
H
LI
D
M
N
D
I
I
REGN
P
T
L
R
T
V
A
E
EVTFPLSD
Q
E
I
I
L
G
E
K
M
M
Q
F
L
KHSQD
P
V
M
A
E
K
MGLRGGVGLAAPQ
L
D
I
S
K
R
I
I
A
V
L
V
P
N
I
VE-EGE-TP
Q
E
AYDL
E
A
I
M
YNPKIVSHSVQ-D-AALGEGEG
C
L
S
VDRN-VP
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
FDKDGE
K
H
R
I
K
L
KGY
N
S
I
V
V
Q
H
EIDHIN
G
I
M
F
Y
DRINEKDPFAVKD
G
L
L
I
LE
1
PsiBlast_PDB
93.77
100%
-112
- C6 -
-
3SW8
1
?
P:
[2-203]
-
S
A
I
E
R
I
T
K
A
A
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
I
----------
E
A
Y
D
L
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
-
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
4
PsiBlast_PDB
93.69
98%
-113
- C6 -
-
2AIE
1
DEF_STRR6
P:
[2-203]
-
S
A
I
E
R
I
V
K
A
A
H
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
I
----------
E
A
Y
D
L
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
-
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
2
PsiBlast_PDB
93.29
98%
-108
- C6 -
-
2AI7
1
DEF_STRR6
A:
[2-203]
-
S
A
I
E
R
I
S
K
A
A
H
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
I
----------
E
A
Y
D
L
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
-
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
3
PsiBlast_PDB
92.30
98%
-111
- C6 -
-
2AIA
1
DEF_STRR6
A:
[2-203]
-
S
A
I
E
R
I
S
K
A
A
H
L
I
D
M
C
D
I
I
R
E
G
N
P
S
L
R
T
V
A
E
E
V
T
F
P
L
S
D
Q
E
I
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
M
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
------------
A
Y
D
L
E
A
I
M
Y
N
P
K
I
V
S
H
S
V
Q
-
D
-
A
A
L
G
E
G
E
G
C
L
S
V
D
R
N
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
F
D
K
D
G
E
K
H
R
I
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
R
I
N
E
K
D
P
F
A
V
K
D
G
L
L
I
L
E
12
PsiBlast_PDB
85.05
82%
-49
- C6 -
-
5JF5
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
5
PsiBlast_PDB
84.35
82%
-53
- C6 -
-
5JEX
1
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
9
PsiBlast_PDB
84.16
82%
-53
- C6 -
-
5JF2
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
10
PsiBlast_PDB
84.12
82%
-53
- C6 -
-
5JF3
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
11
PsiBlast_PDB
83.85
82%
-53
- C6 -
-
5JF4
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
8
PsiBlast_PDB
83.76
82%
-53
- C6 -
-
5JF1
1
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
7
PsiBlast_PDB
83.39
82%
-54
- C6 -
-
5JEZ
-
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
14
PsiBlast_PDB
83.31
82%
-53
- C6 -
-
5JF7
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
15
PsiBlast_PDB
83.21
82%
-52
- C6 -
-
5JF8
2
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
13
PsiBlast_PDB
83.09
82%
-49
- C6 -
-
5JF6
1
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
16
PsiBlast_PDB
83.08
81%
-49
- C6 -
-
5JF0
-
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
-
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
6
PsiBlast_PDB
82.88
82%
-44
- C6 -
-
5JEY
-
DEF_STRA3
A:
[2-204]
-
A
A
I
D
K
L
V
K
A
S
H
L
I
D
M
N
D
I
I
R
E
G
N
P
T
L
R
K
V
A
E
E
V
T
F
P
L
S
E
K
E
E
I
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
I
M
A
E
K
L
G
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
L
V
P
N
V
E
D
A
Q
G
N
-
P
P
K
E
A
Y
S
L
Q
E
V
M
Y
N
P
K
V
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
-
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
R
V
T
I
E
Y
F
D
K
T
G
E
K
H
R
L
K
L
K
G
Y
N
S
I
V
V
Q
H
E
I
D
H
I
D
G
I
M
F
Y
D
R
I
N
E
K
N
P
F
A
V
K
E
G
L
L
I
L
E
19
PsiBlast_PDB
82.64
68%
-112
- C6 -
-
3CMD
-
?
A:
[10-196]
------------
M
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
E
V
A
K
E
V
S
L
P
L
S
E
E
D
I
S
L
G
K
E
M
L
E
F
L
K
N
S
Q
D
P
I
K
A
E
E
L
H
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
S
----------
S
----
L
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
-
D
-
A
C
L
G
E
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
K
I
T
V
S
Y
Y
D
M
N
G
E
K
H
K
I
R
L
K
N
Y
E
S
I
V
V
Q
H
E
I
D
H
I
N
G
V
M
F
Y
D
H
I
N
D
Q
N
P
F
A
L
K
E
G
V
L
V
I
E
18
PsiBlast_PDB
82.56
68%
-114
- C6 -
-
3G6N
-
?
A:
[5-191]
------------
M
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
E
V
A
K
E
V
S
L
P
L
S
E
E
D
I
S
L
G
K
E
M
L
E
F
L
K
N
S
Q
D
P
I
K
A
E
E
L
H
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
S
----------
S
----
L
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
-
D
-
A
C
L
G
E
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
---
V
V
R
H
A
K
I
T
V
S
Y
Y
D
M
N
G
E
K
H
K
I
R
L
K
N
Y
E
S
I
V
V
Q
H
E
I
D
H
I
N
G
V
M
F
Y
D
H
I
N
D
Q
N
P
F
A
L
K
E
G
V
L
V
I
E
17
PsiBlast_PDB
80.92
74%
-48
- C6 -
-
2OS3
1
DEF_STRP1
A:
[1-203]
-
S
A
Q
D
K
L
I
K
P
S
H
L
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
A
V
A
K
E
V
S
L
P
L
C
D
E
D
I
L
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
L
G
L
R
A
G
V
G
L
A
A
P
Q
I
D
V
S
K
R
I
I
A
V
L
V
P
N
L
P
D
K
E
G
N
-
P
P
K
E
A
Y
S
W
Q
E
V
L
Y
N
P
K
I
V
S
H
S
V
Q
-
D
-
A
A
L
S
D
G
E
G
C
L
S
V
D
R
V
-
V
E
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
Y
D
K
E
G
Q
Q
H
R
I
K
L
K
G
Y
N
A
I
V
V
Q
H
E
I
D
H
I
N
G
V
L
F
Y
D
R
I
N
A
K
N
P
F
E
T
K
E
E
L
L
I
L
D
20
PsiBlast_PDB
80.70
68%
-113
- C6 -
-
2OS1
1
DEF_ENTFA
A:
[1-187]
------------
M
I
T
M
K
D
I
I
R
E
G
N
P
T
L
R
A
V
A
E
E
V
P
V
P
I
T
E
E
D
R
Q
L
G
E
D
M
L
T
F
L
K
N
S
Q
D
P
V
K
A
E
E
L
Q
L
R
G
G
V
G
L
A
A
P
Q
L
D
I
S
K
R
I
I
A
V
H
V
P
-----------
S
----
L
S
T
V
M
Y
N
P
K
I
L
S
H
S
V
Q
-
D
-
V
C
L
G
E
G
E
G
C
L
S
V
D
R
D
-
V
P
G
Y
---
V
V
R
H
N
K
I
T
V
S
Y
F
D
M
A
G
E
K
H
K
V
R
L
K
N
Y
E
A
I
V
V
Q
H
E
I
D
H
I
N
G
I
M
F
Y
D
H
I
N
K
E
N
P
F
A
L
K
E
G
V
L
V
I
E
153
HHSearch
78.85
73%
-46
- C6 -
-
2OS3
1
DEF_STRP1
A:
[1-202]
-
S
A
Q
D
K
L
I
K
P
S
H
L
I
T
M
D
D
I
I
R
E
G
N
P
T
L
R
A
V
A
K
E
V
S
L
P
L
C
D
E
D
I
L
L
G
E
K
M
M
Q
F
L
K
H
S
Q
D
P
V
M
A
E
K
L
G
L
R
A
G
V
G
L
A
A
P
Q
I
D
V
S
K
R
I
I
A
V
L
V
P
N
L
P
D
-
K
E
G
N
P
P
K
E
A
Y
S
W
Q
E
V
L
Y
N
P
K
I
V
S
H
S
V
Q
D
A
-
A
L
-
S
D
G
E
G
C
L
S
V
D
-
R
V
V
E
G
Y
---
V
V
R
H
A
R
V
T
V
D
Y
Y
D
K
E
G
Q
Q
H
R
I
K
L
K
G
Y
N
A
I
V
V
Q
H
E
I
D
H
I
N
G
V
L
F
Y
D
R
I
N
A
K
N
P
F
E
T
K
E
E
L
L
I
L
-
25
PsiBlast_CBE
73.86
50%
-95
- C6 -
-
2OKL
3
DEF2_BACCR
B:
[2-184]
------------
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
----------
T
D
A
D
G
T
L
Y
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
-
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
---
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
A
P
D
D
S
K
P
L
E
24
PsiBlast_CBE
73.82
55%
-90
- C6 -
-
1LQY
1
DEF2_GEOSE
A:
[1-178]
------------
M
I
T
M
K
D
I
I
K
E
G
H
P
T
L
R
K
V
A
E
P
V
P
L
P
P
S
E
E
D
K
R
I
L
Q
S
L
L
D
Y
V
K
M
S
Q
D
P
E
L
A
A
K
Y
G
L
R
P
G
I
G
L
A
A
P
Q
I
N
V
S
K
R
M
I
A
V
H
V
T
D
--
E
-
N
G
T
-
L
Y
S
Y
A
------
L
F
N
P
K
I
V
S
H
S
V
Q
-
Q
-
C
Y
L
T
T
G
E
G
C
L
S
V
D
R
D
-
V
P
G
Y
---
V
L
R
Y
A
R
I
T
V
T
G
T
T
L
D
G
E
E
V
T
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
I
M
F
Y
D
R
I
N
P
A
D
P
F
Q
V
P
D
G
-----
26
PsiBlast_CBE
71.36
50%
-89
- C6 -
-
2OKL
4
DEF2_BACCR
A:
[1-184]
-----------
H
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
----------
T
D
A
D
G
T
L
Y
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
-
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
R
E
-
V
P
G
Y
---
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
A
P
D
D
S
K
P
L
E
167
HHSearch
68.91
57%
-46
- C6 -
-
1LQY
1
DEF2_GEOSE
A:
[2-178]
-------------
I
T
M
K
D
I
I
K
E
G
H
P
T
L
R
K
V
A
E
P
V
P
L
P
P
S
E
E
D
K
R
I
L
Q
S
L
L
D
Y
V
K
M
S
Q
D
P
E
L
A
A
K
Y
G
L
R
P
G
I
G
L
A
A
P
Q
I
N
V
S
K
R
M
I
A
V
H
V
T
D
E
N
G
----------
T
L
Y
S
Y
A
L
F
N
P
K
I
V
S
H
S
V
Q
-
Q
C
Y
L
-
T
T
G
E
G
C
L
S
V
D
-
R
D
V
P
G
Y
---
V
L
R
Y
A
R
I
T
V
T
G
T
T
L
D
G
E
E
V
T
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
I
M
F
Y
D
R
I
N
P
A
D
P
F
Q
V
P
D
G
-----
155
HHSearch
66.19
52%
-46
- C6 -
-
2OKL
3
DEF2_BACCR
B:
[2-184]
------------
M
L
T
M
K
D
V
I
R
E
G
D
P
I
L
R
N
V
A
E
E
V
S
L
P
A
S
E
E
D
T
T
T
L
K
E
M
I
E
F
V
I
N
S
Q
D
P
E
M
A
E
K
Y
S
L
R
P
G
I
G
L
A
A
P
Q
I
G
V
S
K
K
M
I
A
V
H
V
T
D
A
D
G
----------
T
L
Y
S
H
A
L
F
N
P
K
I
I
S
H
S
V
E
-
R
-
T
Y
L
Q
G
G
E
G
C
L
S
V
D
-
R
E
V
P
G
Y
---
V
P
R
Y
T
R
I
T
V
K
A
T
S
I
N
G
E
E
V
K
L
R
L
K
G
L
P
A
I
V
F
Q
H
E
I
D
H
L
N
G
V
M
F
Y
D
H
I
N
K
E
N
P
F
A
A
P
D
D
S
K
P
L
E
37
PsiBlast_CBE
65.24
34%
-80
- C6 -
-
1VEY
1
DEF_LEPIN
B:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
42
PsiBlast_CBE
64.07
34%
-82
- C6 -
-
1SV2
1
DEF_LEPIN
A:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
40
PsiBlast_CBE
63.76
34%
-80
- C6 -
-
1VEV
3
DEF_LEPIN
A:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
39
PsiBlast_CBE
63.25
34%
-84
- C6 -
-
1VEV
2
DEF_LEPIN
B:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
41
PsiBlast_CBE
63.11
34%
-83
- C6 -
-
1SV2
2
DEF_LEPIN
B:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
34
PsiBlast_CBE
62.93
34%
-93
- C6 -
-
1Y6H
4
DEF_LEPIN
A:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
38
PsiBlast_CBE
61.69
34%
-82
- C6 -
-
1VEY
1
DEF_LEPIN
A:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
36
PsiBlast_CBE
61.62
34%
-79
- C6 -
-
1VEZ
8
DEF_LEPIN
A:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
33
PsiBlast_CBE
61.14
34%
-79
* C6 *
-
1Y6H
5
DEF_LEPIN
B:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
35
PsiBlast_CBE
60.64
34%
-79
- C6 -
-
1VEZ
7
DEF_LEPIN
B:
[5-169]
------------------
I
L
R
M
G
D
P
I
L
R
K
I
S
E
----
P
V
T
E
D
E
I
----
Q
T
K
E
F
K
K
L
I
R
D
--
M
F
D
T
M
R
H
A
E
G
V
G
L
A
A
P
Q
I
G
I
L
K
Q
I
V
V
V
G
S
E
D
N
E
R
-
Y
P
G
-
T
P
D
V
P
---
E
R
I
I
L
N
P
-
V
I
T
P
L
T
K
-
D
-
T
S
-
G
F
W
E
G
C
L
S
V
P
-
G
-
M
R
G
Y
---
V
E
R
P
N
Q
I
R
M
Q
W
M
D
E
K
G
N
Q
F
D
E
T
I
D
G
Y
K
A
I
V
Y
Q
H
E
C
D
H
L
Q
G
I
L
Y
V
D
R
L
K
D
T
K
L
F
G
F
N
E
T
L
----
31
PsiBlast_CBE
58.45
35%
-91
- C6 -
-
1RL4
2
?
B:
[11-168]
------------------
I
V
K
Y
P
D
P
I
L
R
R
R
S
E
E
V
T
-
N
F
D
D
N
L
K
R
V
V
R
K
M
F
D
I
M
Y
E
S
K
------------
G
I
G
L
S
A
P
Q
V
N
I
S
K
R
I
I
---
V
W
N
-----------------
R
I
F
I
N
P
S
I
V
E
Q
S
L
----
V
K
L
K
L
I
E
G
C
L
S
F
P
-
G
-
I
E
G
K
---
V
E
R
P
S
I
V
S
I
S
Y
Y
D
I
N
G
Y
K
H
L
K
I
L
K
G
I
H
S
R
I
F
Q
H
E
F
D
H
L
N
G
T
L
F
I
D
K
M
T
Q
V
D
K
K
K
V
R
P
K
L
----
64
PsiBlast_CBE
50.73
35%
-51
- C6 -
-
4WXL
1
DEF_HAEI8
D:
[35-160]
------------------------------------------------------------
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
------
E
G
D
-
K
Q
N
Q
F
-----
V
L
I
N
P
E
I
L
A
---
S
-
E
-
G
E
T
G
I
E
E
G
C
L
S
I
-----
P
G
F
RAL
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
R
Q
R
I
K
E
K
L
I
---
68
PsiBlast_CBE
50.22
35%
-54
- C6 -
-
4WXK
2
DEF_HAEI8
D:
[35-160]
------------------------------------------------------------
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
------
E
G
D
-
K
Q
N
Q
F
-----
V
L
I
N
P
E
I
L
A
---
S
-
E
-
G
E
T
G
I
E
E
G
C
L
S
I
-----
P
G
F
RAL
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
R
Q
R
I
K
E
K
L
I
---
67
PsiBlast_CBE
49.25
35%
-47
- C6 -
-
4WXL
2
DEF_HAEI8
A:
[35-160]
------------------------------------------------------------
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
------
E
G
D
-
K
Q
N
Q
F
-----
V
L
I
N
P
E
I
L
A
---
S
-
E
-
G
E
T
G
I
E
E
G
C
L
S
I
-----
P
G
F
R
A
L
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
R
Q
R
I
K
E
K
L
I
---
70
PsiBlast_CBE
49.16
35%
-48
- C6 -
-
4WXK
1
DEF_HAEI8
B:
[35-160]
------------------------------------------------------------
M
F
D
T
M
Y
Q
E
K
G
I
G
L
A
A
P
Q
V
D
I
L
Q
R
I
I
T
I
D
V
------
E
G
D
-
K
Q
N
Q
F
-----
V
L
I
N
P
E
I
L
A
---
S
-
E
-
G
E
T
G
I
E
E
G
C
L
S
I
-----
P
G
F
RAL
V
P
R
K
E
K
V
T
V
R
A
L
D
R
D
G
K
E
F
T
L
D
A
D
G
L
L
A
I
C
I
Q
H
E
I
D
H
L
N
G
I
L
F
V
D
Y
L
S
P
L
K
R
Q
R
I
K
E
K
L
I
---