@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1413: (2018-01-11 )
MRLTQMPSEFQKALPVLEKIKEAGFEAYFVGGSVRDALLHSPIHDVDIATSSYPEETKQIFPRTADIGIEHGTVLVLDGDEEYEVTTFRTEDVYVDYRRPSAVSFVRSLEEDLKRRDFTVNAFALDETGEIVDLFHGLEDLEKQVLRAVGVASERFNEDALRIMRGFRFQASLGFALEPETFKAMKTLTPLLEKISVERTFVEFDKLLLAPFWRRGLASMIESQAYDYLPDMASSQDKLNRLFDLETDFTFESSEQAWAALLWALEIENAQSFLKSWKTSRQFAKQVQDLLIILALRENGELSKRDCYRFDIDLLLQAENLRQAQGKEVNPQAITEKYQSLTIHDKKEIQINGGILIKEYGYQPGPDLGEILTEIEFAIVDGELENNREAIHAYLREKK
Atome Classification :
(32 SA)
-----.........10-------...-....-..20...----.....30........40.---.......50........60..-.----.-----....----70....-------------...----.----80........-90........100.....--..110.......120..----..-..---------.---------130-.......140.......150.......160.......170..---..---...180.......--190.......200.......210.......220.......-230....---------...240..---..--...------------250---------------------------------.-----------------------------------.....-----...260--.....---..---------------------270.......280.......290...-.---...--300.-----------.......310......-..320-....-....---.330.--..----...---...340..-.....350........360.......370.......380.......390.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----MRLTQM
P
S
E
F
--------
Q
K
A
-
L
P
V
L
-
E
K
I
K
E
AG----F
E
A
Y
F
VGG
S
V
R
D
A
L
L
HSP---IHDVDIATSSY
P
E
E
T
K
Q
IFPR-T----A-----DIGI----EH
G
T
V
L
-------------
V
L
D----G----DEE
Y
E
V
T
T
F
R
-TE
D
V
Y
V
D
YRR
P
S
A
V
S
F
V
R
--
S
L
E
E
D
L
K
RRD
F
T
V
N
A
F
A
----LD-ET---------G---------
E
I
V
-
D
L
F
H
G
L
E
D
L
E
K
Q
V
L
R
A
VGV
A
S
ERF
N
E
D
A
L
R
I
M
R
GF
R
F
Q
ASLG---FA---LE
P
E
T
F
K
A
M
K
T
L
T
--
P
L
L
E
K
I
S
V
E
R
T
F
V
E
F
D
K
L
L
L
A
P
F
W
R
R
G
L
A
S
M
I
E
S
Q
A
Y
D
YL-PDMAS
S
Q
---------
D
K
L
N
R
L
FD---LE--TDF------------T-----------------------------------F-----------------------------------ESS
E
Q
-----
A
W
A
A
L
L
--
W
A
LEI---E
N
---------------------
A
Q
S
F
L
K
S
W
K
T
S
R
Q
F
A
K
Q
V
Q
D
L
L
I
I
L
A
-L---REN--G-EL-----------SKR
D
C
Y
R
F
D
-
I
D
L
L
L
Q
-
A
E
N
---
L
R
Q
A-QGKE---V
N
--
P
--
Q
A
----
I
T
E
---
K
Y
Q
S
L
T
IH-D
K
K
E
I
Q
I-NG
G
I
L
I
K
EYGYQPGP
D
L
G
E
I
L
T
E
I
E
F
A
I
VDGELEN
N
R
E
A
I
H
A
Y
L
REKK
1
PsiBlast_PDB
90.68
43%
-71
- C4 -
-
1MIY
1
CCA_GEOSE
A:
[1-396]
----------
M
K
P
P
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
---------
K
Q
L
-
R
L
A
A
---
A
Y
--
R
W
P
------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
--
H
A
L
G
V
---
Q
E
---------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
---
P
R
P
--
E
-
A
W
-----------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
F
T
G
A
P
---
P
G
--
P
W
H
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
2
PsiBlast_PDB
90.42
43%
-74
- C4 -
-
1MIV
-
CCA_GEOSE
A:
[5-396]
--------------
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
---------
K
Q
L
-
R
L
A
A
---
A
Y
--
R
W
P
------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
--
H
A
L
G
V
---
Q
E
---------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
---
P
R
P
--
E
-
A
W
-----------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
F
T
G
A
P
---
P
G
--
P
W
H
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
21
PsiBlast_CBE
90.31
43%
-69
- C4 -
-
1MIY
1
CCA_GEOSE
B:
[1-396]
----------
M
K
P
P
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
---------
K
Q
L
-
R
L
A
A
---
A
Y
--
R
W
P
------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
--
H
A
L
G
V
---
Q
E
---------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
---
P
R
P
--
E
-
A
W
-----------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
F
T
G
A
P
---
P
G
--
P
WH
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
3
PsiBlast_PDB
89.50
43%
-73
- C4 -
-
1MIW
1
CCA_GEOSE
A:
[5-396]
--------------
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
---------
K
Q
L
-
R
L
A
A
---
A
Y
--
R
W
P
------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
--
H
A
L
G
V
---
Q
E
---------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
I
---
P
R
P
--
E
-
A
W
-----------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
F
T
G
A
P
---
P
G
--
P
W
H
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
40
HHSearch
87.64
43%
-54
* C4 *
-
1MIV
-
CCA_GEOSE
B:
[1-396]
----------
M
K
P
P
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
--
P
G
L
A
G
K
---------
E
K
Q
L
R
L
A
A
---
A
Y
R-
W
P
-------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
H-
A
L
G
V
Q
---
E
----------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
-----
D
I
P
--
R
-
P
E
AW---------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
-
F
T
G
A
PPG
P
W
--
H
--
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
39
HHSearch
86.18
43%
-51
- C4 -
-
1MIW
1
CCA_GEOSE
A:
[1-396]
----------
M
K
P
P
F
--------
Q
E
A
-
L
G
I
I
-
Q
Q
L
K
Q
H
G
----
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
---
I
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
-
T
----
I
-----
D
V
G
S
----
K
H
G
T
V
V
-------------
V
V
H
----
K
----
G
K
A
Y
E
V
T
T
F
K
-
T
D
G
---------
S
V
T
F
V
R
--
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
----
M
D
-
E
Y
---------
G
---------
T
I
I
-
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
T
G
L
N
A
Y
L
--
P
G
L
A
G
K
---------
E
K
Q
L
R
L
A
A
---
A
Y
R-
W
P
-------------
W
-----------------------------------
L
-----------------------------------
A
A
R
E
E
-----
R
W
A
L
L
C
H
-
A
L
G
V
Q
---
E
----------------------
S
R
P
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
-----
D
I
P
--
R
-
P
E
AW---------
T
N
E
Q
L
F
S
A
G
-
L
E
R
A
L
S
-
V
E
T
---
V
R
A
A
-
F
T
G
A
PP
G
P
W
--
H
--
E
K
----
L
R
R
---
R
F
A
S
L
P
I
K
-
T
K
G
E
L
A
V
-
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
-
49
HHSearch
63.70
28%
-59
- C4 -
-
3AQL
1
?
A:
[15-350]
-----------
K
D
I
S
--------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
-
G
-------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
D--------
F
---------
T
V
R
-
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
---------
F
T
E
N
G
D
S
P
---
M
E
R
I
I
E
Q
------------
V
L
K
N
T
D
T
R
I
H
N
DM-----------------------
R
-----------------------------------
V
N
P
A
F
-----
L
F
A
A
M
F
W
Y
P
L
L
E
T
---
A
Q
K
I
A
Q
E
S
GLT
Y
H
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
K
R
L
T
T
L
T
R
D
I
W
Q
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
63.21
28%
-47
- C4 -
-
3AQK
-
?
A:
[31-366]
-----------
K
D
I
S
--------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
---------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
D--------
F
---------
T
V
R
-
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
---------
F
T
E
N
G
D
S
P
---
M
E
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
M
-----------------------------------
R
-----------------------------------
V
N
P
A
F
-----
L
F
A
A
M
F
W
Y
P
L
L
E
T
---
A
Q
K
I
A
Q
E
S
G
L
T
Y
H
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
R
S
L
A
I
P
K
R
L
T
T
L
T
R
D
I
W
Q
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
60.96
23%
59
- C4 -
-
4X4W
3
TRNT1_HUMAN
A:
[1-409]
M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
F
--------
T
E
G
-
L
K
S
L
T
E
L
F
V
K
E
N
----
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
---
P
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
-
A
----------
G
I
R
M
----
I
N
G
T
I
T
-------------
A
R
L
----
H
----
E
E
N
F
E
I
T
T
L
R
-
I
D
V
T
----
T
D
G
A
E
V
E
F
T
T
--
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
----
L
G
-
F
D
---------
G
---------
T
L
F
-
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
---
D
K
PGD
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
G
L
P
A
N
A
S
L
---------
E
E
F
D
K
V
S
K
---
N
V
--
D
G
F
------------
S
-----------------------------------
P
-----------------------------------
K
P
V
T
L
-----
L
A
S
L
F
K
--
V
Q
D
D
V
---
T
K
---------------------
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
D
L
I
-
K
---
A
T
D
--
S
-
S
D
-----------
P
L
K
P
Y
Q
D
F
I
-
I
D
S
--
D
-
A
T
T
---
R
V
C
E
-
L
L
K
Y
---
Q
G
--
E
--
H
C
----
L
L
K
---
E
M
Q
Q
W
S
I
P
-
P
F
P
V
-----
S
G
H
D
I
R
K
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
32
Fugue
56.95
23%
37
- C4 -
-
3AQL
1
?
A:
[1-411]
-----
Q
V
T
V
I
P
R
E
Q
H
AISRKDIS
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
--------------
G
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
V
A
D
---------
F
---------
T
V
R
-
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
FTENGDS
P
M
E
R
I
I
E
Q
V
L
---
K
N
--
T
D
T
------------
R
-----------------------------------
I
-----------------------------------
H
N
D
M
R
VN
P
A
F
L
F
A
A
M
F
--
W
Y
P
L
L
---
E
T
---------------------
A
Q
K
I
A
Q
--
E
S
G
L
T
Y
H
D
A
F
A
L
A
M
N
D
V
L
-
D
---
E
A
C
--
R
-
S
L
-----------
A
I
P
K
R
L
T
T
L
-
T
R
D
I
W
Q
-
L
Q
L
R
--
M
S
R
R
-
Q
G
K
-------------------------
R
A
W
K
L
L
-
E
H
P
K
F
R
A
-
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
-
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
--------
43
HHSearch
55.74
22%
17
- C4 -
-
5HC9
-
?
A:
[12-418]
----------
V
E
R
V
D
--------
P
K
I
-
L
N
L
F
-
R
L
L
G
K
F
G
D
E
V
N
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
---
N
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
Y
A
K
R
-
F
L
P
G
K
L
-----
V
K
H
D
----
K
F
M
T
A
S
-------------
L
F
L
----
K
G---
G
L
R
I
D
I
A
T
A
R
-
L
E
Y
Y
E
S
P
A
K
L
P
D
V
E
--
M
S
--
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
----
I
K
-
L
N
PKDF-----
G
---------
L
L
I
-
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
V
L
H
T
--
L
S
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
D
---
F
R
---
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
F
D
V
I
K
H
L
-
F
P
K
T
Y
Y
T
---------
P
S
M
D
E
K
M
E
---
N
L
--
F
R
N
I
P
W
V
E
-------
E
-----------------------------------
N
-----------------------------------
F
G
E
V
D
-----
R
F
Y
A
V
L
H
-
V
F
L
E
F
YD
D
E
S
---------------------
W
K
E
V
R
D
R
Y
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
A
L
---
L
E
M
L
S
E
-
R
V
-----------
P
A
S
F
V
Y
P
L
V
-
K
G
V
S
N
E
T
I
C
H
---
F
L
A
Y
-
L
S
G
----
E
K
--
E
--
G
L
----
F
K
S
------
Y
L
L
K
I
K
N
T
K
L
E
K
I
-
N
G
E
Y
L
I
R
-
K
G
I
T
S
G
K
I
I
G
E
V
L
E
K
I
L
M
K
K
L
D
G
D
T
R
D
E
E
E
I
L
E
-------
47
HHSearch
55.59
23%
32
- C4 -
-
3WFO
-
?
A:
[27-448]
-----------------------------
V
A
-
K
V
L
-
P
R
E
----
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
VGY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
------------
R
I
G
G
----
H
F
F
V
F
E
P
T
I
A
S
--------
V
V
L
H
L
PP
Y
----
R
Y
R
F
D
F
S
P
L
K
-
G
K
D
------------
L
E
K
--
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
----
V
N
-
L
D
---------
D
V
L
SIGA
K
Q
T
I
V
Y
-
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
--
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
---
L
Q
---
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
-
I
P
E
I
G
R
L
---------
R
E
V
K
D
--------P
L
D
E
H
------------
T
L
K
T
L
E
Y
L
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
-----------------------------------
D
V
E
L
L
-----
K
W
G
A
L
F
H
-
D
I
G
K
P
---
Q
T
FVTFYE
H
D
K
V
G
A
Q
I
-------
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
--------
L
--
R
-
P
F
F
L
R
E
A
F
K
K
GEL
K
R
R
G
M
A
N
F
W
-
R
E
C
G
D
I
-
A
P
H
L
F
L
L
S
I
A
-
D
A
M
A
S
GD
E
E
E
D
I
--
K
A
L
M
E
T
I
A
E
L
E
S
F
N
R
N
E
M
K
----------------------------------------------------------
41
HHSearch
55.59
22%
29
- C4 -
-
4X4W
2
TRNT1_HUMAN
A:
[15-407]
-------------
F
T
--------
E
G
L
-
K
S
L
T
-
E
L
F
V
K
E
N
----
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
---
P
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
-
A
----
G
I
R
M
I
N----------
G
T
I
T
-------------
A
R
L
----
H
----
E
E
N
F
E
I
T
T
L
R
-
I
D
V
T
T
-
D
G
--
A
-
E
V
E
F
T
T
--
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
----
L
G
-
F
D
---------
G
---------
T
L
F
-
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
DKP
G
D
---
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
-
G
L
P
A
N
A
S
L
--------
E
E
F
D
K
V
S
K
----
N
--
V
D
G
------------
F
-----------------------------------
S
-----------------------------------
P
K
P
V
T
-----
L
L
A
S
L
F
K-
V
Q
D
D
---------------------------
V
T
K
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
-
D
L--
I
K
A
--
T
D
S
S
-----------
D
P
L
K
P
Y
Q
D
F
I
I
D
-
S
----
D
A
---
T
T
R
V
-
C
E
L
----
L
K
--
Y
--
Q
G
----
E
H
C
---
L
L
K
E
M
Q
Q
W
-
S
I
P
P
F
P
V
-
S
G
H
D
I
R
-
K
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
--
44
HHSearch
55.56
25%
19
- C4 -
-
4WBY
1
?
A:
[10-396]
--------------
E
--------
E
I
A
-
R
E
V
G
-
Q
I
A
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
H
----
G
V
N
V
--
H
P
F
P
----
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
--------------
P
A
--
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
----
I
S
-
V
N
LEDY-----
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
--
V
S
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
-
I
E
G
F
Q
W
N
---------
E
K
V
L
Q
K
L
Y
A
L
R
K
V
V
-
D
W
H
------------
A
L
E
F
S
EER----------------------------
I
-----------------------------------
D
Y
G
W
L
-----
Y
L
L
I
L
I
S-
N
L
D
Y
E
---
R
----------------------
G
K
H
F
L
E
E
M
S
A
P
S
W
V
R
E
T
Y
K
F
M
K
F
K
L
G
-
S
L
K
E
E
L
K
--
K
-
A
K
-----------
E
N
Y
E
V
Y
R
L
L
-
K
P
L
H
T
S
-
V
L
L
---
L
L
M
L
-
E
E
------------
E
L
----
K
E
K
---
I
K
L
Y
L
E
K
L
-
R
K
V
K
-------------
G
L
K
G
K
E
-
L
G
E
R
I
E
E
L
K
R
E
I
M
N
K
-----------------
7
PsiBlast_PDB
54.16
34%
-67
- C4 -
-
3AQK
-
?
A:
[35-247]
-----------------------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
---------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
---------
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
53.45
23%
30
- C4 -
-
3WFP
-
?
C:
[2-362]
-----------
L
N
F
Y
--------
L
S
Y
F
D
D
V
A
-
K
V
L
-
P
R
E
----
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
VGY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
------------
R
I
G
G
----
H
F
F
V
F
E
KRGFLIKRPTIAS
V
V
L
----
H
LPPY
R
Y
R
F
D
F
S
P
L
K
-
G
K
------------
D
L
E
K
--
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
----
V
N
-
L
D
DVLSIGAKQ
T
---------
I
V
Y
-
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
--
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
---
L
Q
---
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
Y
G
V
L
E
A
I
-
I
P
E
I
G
R
L
---------
R
E
V
K
D
-------
P
L-
D
E
H
------------
T
-----------------------------------
L
KTLEYLEQVIEDRAKYLSAELLENFGKKRVLGEFT
D
V
E
L
L
-----
K
W
G
A
L
F
H-
D
I
G
K
P
---
Q
T
FVTFYEHDKVGAQI-------
V
R
E
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
52.88
25%
-
- C4 -
-
4X0A
-
?
A:
[2-381]
-----------------------------
V
G
-
Q
I
A
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
H
----
G
V
N
V
--
H
P
F
P
----
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
T
------------
E
P
A
--
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
----
I
S
-
V
N
LEDY-----
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
--
V
S
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
Y
R
V
L
E
E
I
-
I
E
G
F
Q
W
N
---------
E
K
V
L
Q
K
L
Y
A
L
R
K
V
V
-
D
W
H
------------
A
L
EFSEER----------------------------
I
-----------------------------------
D
Y
G
W
L
-----
Y
L
L
I
L
I
S
-
N
L
D
Y
E
---
R
----------------------
G
K
H
F
L
E
E
M
S
A
P
S
W
V
R
E
T
Y
K
F
M
K
F
K
L
G
-
S
L
K
E
E
L
K
--
K
-
A
K
-----------
E
N
Y
E
V
Y
R
L
L
-
K
P
L
H
T
S
-
V
L
L
---
L
L
M
L
-
E
E
------------
E
L
----
K
E
K
---
I
K
L
Y
L
E
K
L
-
R
K
V
K
L
P
K
E
K
I
E
E
L
K
-----
K
G
K
E
-
L
G
E
R
I
E
E
L
K
R
E
I
M
N
------------------
23
PsiBlast_CBE
52.12
34%
-16
- C4 -
-
3AQN
1
?
B:
[19-231]
-----------------------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
G--------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
---------
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
51.98
34%
-14
- C4 -
-
3AQL
1
?
B:
[19-231]
-----------------------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
G--------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
---------
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
51.58
34%
-18
- C4 -
-
3AQL
1
?
A:
[19-231]
-----------------------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
G--------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
---------
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.61
34%
-14
- C4 -
-
3AQN
1
?
A:
[19-231]
-----------------------
E
N
A
-
L
K
V
M
-
Y
R
L
N
K
A
G
----
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
---
P
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
-
C
----
R
-----
L
V
G
R
----
R
F
R
L
A
H
-------------
V
M
F
----
G
----
P
E
I
I
E
V
A
T
F
R
G--------------
N
I
F
G
--
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
----
Y
S
-
V
A
---------
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.62
38%
9
- C4 -
-
4WC6
1
?
A:
[7-185]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
----------
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
45.16
38%
10
- C4 -
-
4WC0
1
?
B:
[7-201]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
HPFP
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----------------PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
ISVN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
45.08
38%
13
- C4 -
-
4WC5
1
?
A:
[7-185]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
----------
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
45.06
38%
11
- C4 -
-
4WC4
1
?
A:
[7-185]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
----------
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
44.85
38%
12
- C4 -
-
4WC7
1
?
A:
[7-185]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
----------
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
44.52
38%
10
- C4 -
-
4WC1
1
?
A:
[7-187]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----------------PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.26
38%
11
- C4 -
-
4WC0
1
?
A:
[7-187]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----------------PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
44.06
38%
18
- C4 -
-
4WC2
1
?
A:
[7-185]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
----------
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
43.89
38%
13
- C4 -
-
4WC1
1
?
B:
[7-201]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
HPFP
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----------------PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
ISVN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
42.52
38%
9
- C4 -
-
1VFG
1
?
A:
[7-181]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
H
P
F
P
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
---------
V
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
VN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
42.44
38%
12
- C4 -
-
1VFG
1
?
B:
[7-204]
-----------------------------------
K
E
M
G
----
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
---
V
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
-
R
----
H
-----
G
V
N
V
HPFP
E
F
G
T
A
H
-------------
L
K
I
----
G
----
K
L
K
L
E
F
A
T
A
R
-
R
E
----
T
---------
V
E
PA
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
ISVN
L
E
-
D
Y
---------
G
---------
T
L
I
-
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------