@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1580: (2018-01-15 )
MTKLIFMGTPDFSATVLKGLLTDDRYEILAVVTQPDRAVGRKKVIQETPVKQAAKEAGLSIYQPEKLSGSPEMEDLMKLGADGIVTAAFGQFLPSKLLDSMDFAVNVHASLLPRHRGGAPIHYALIQGDEEAGVTIMEMVKEMDAGDMISRRSIPITDEDNVGTLFEKLALVGRDLLLDTLPAYIAGDIKPEPQDTSQVTFSPNIKSEEEKLNWNKTNRQLFNQIRGMNPWPVAHTFLKGDRFKIYEALPVEGQGNPGEILSIGKKELIVATAEGALSLKQVQPAGKPKMDIASFLNGVGRTLTVGERFGD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........-100.-......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220......-.-230.......240....--..--.--250--...---.--...260.......270.-..-....280.-......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
K
L
I
F
MGTPD
F
S
A
T
V
L
K
G
L
LTDD
R
Y
E
I
L
A
V
V
TQP
D
R
AV
G
R
K
K
V
I
Q
ET
P
V
K
Q
A
A
K
EAG
L
S
IYQPEKLSGSP
E
M
E
D
L
M
K
LGADG
I
V
T
A
A
F
G
Q
F
L
P
S
K
L
L
D
-SMD
F
-
A
V
N
V
H
A
S
LLPRHRGGA
P
I
H
Y
A
L
I
QGDEEA
G
V
T
I
M
E
M
V
K
EMDAGDMISRRSIPITDED
N
V
G
T
L
F
E
K
L
A
L
V
G
R
D
L
L
L
D
T
L
P
A
Y
I
AGDIKPEPQDT
S
Q
V
T
FSPNIK
S
E
E
E
KLNWN
K
T
N
R
Q
L
F
N
Q
IRGM-N-PW
P
V
A
H
T
FLKGD
R
F
K
I
Y
--
E
A--L--PVE--GQG---N--P
G
E
I
L
SIGK
K
E
L
I
V
A
TA-EG-
A
L
S
L
K
QVQ-PAGKPK
M
D
I
A
S
F
L
N
GVGR
T
L
TVGERFGD
56
HHSearch
89.30
45%
-32
- C7 -
-
4IQF
1
FMT_BACAN
D:
[4-305]
M
I
K
V
V
F
M
G
T
P
D
F
S
V
P
V
L
R
R
L
I
E
-
D
G
Y
D
V
I
G
V
V
T
Q
P
D
R
P
V
G
R
K
K
V
L
T
P
T
P
V
K
V
E
A
E
K
H
G
I
P
V
L
Q
P
L
R
I
R
E
K
D
E
Y
E
K
V
L
A
L
E
P
D
L
I
V
T
A
A
F
G
Q
I
V
P
N
E
I
L
E
-
A
P
K
Y
G
C
I
N
V
H
A
S
L
L
P
E
L
R
G
G
A
P
I
H
Y
A
I
M
E
G
K
E
K
T
G
I
T
I
M
Y
M
V
E
K
L
D
A
G
D
I
L
T
Q
V
E
V
E
I
E
E
R
E
T
T
G
S
L
F
D
K
L
S
E
A
G
A
H
L
L
S
K
T
V
P
L
L
I
Q
G
K
L
E
P
I
K
Q
N
E
E
E
V
T
F
A
Y
N
I
K
R
E
Q
E
K
I
D
W
T
K
T
G
E
E
V
Y
N
H
I
R
G
L
-
N
-
P
W
P
V
A
Y
T
T
L
A
G
Q
V
V
K
V
W
--
W
G
--
E
--
K
V
P
VT
K
S
A
---
E
--
A
G
T
I
V
A
I
E
E
D
G
F
V
V
A
T
G
-
N
E
T
G
V
K
I
T
E
L
Q
-
P
S
G
K
K
R
M
S
C
S
Q
F
L
R
G
T
------------
1
PsiBlast_PDB
88.53
44%
-33
- C7 -
-
4IQF
2
FMT_BACAN
A:
[6-304]
--
K
V
V
F
M
G
T
P
D
F
S
V
P
V
L
R
R
L
I
-
E
D
G
Y
D
V
I
G
V
V
T
Q
P
D
R
P
V
G
R
K
K
V
L
T
P
T
P
V
K
V
E
A
E
K
H
G
I
P
V
L
Q
P
L
R
I
R
E
K
D
E
Y
E
K
V
L
A
L
E
P
D
L
I
V
T
A
A
F
G
Q
I
V
P
N
E
I
L
E
-
A
P
K
Y
G
C
I
N
V
H
A
S
L
L
P
E
L
R
G
G
A
P
I
H
Y
A
I
M
E
G
K
E
K
T
G
I
T
I
M
Y
M
V
E
K
L
D
A
G
D
I
L
T
Q
V
E
V
E
I
E
E
R
E
T
T
G
S
L
F
D
K
L
S
E
A
G
A
H
L
L
S
K
T
V
P
L
L
I
Q
G
K
L
E
P
I
K
Q
N
E
E
E
V
T
F
A
Y
N
I
K
R
E
Q
E
K
I
D
W
T
K
T
G
E
E
V
Y
N
H
I
R
G
L
-
N
-
P
W
P
V
A
Y
T
T
L
A
G
Q
V
V
K
V
W
W
G
E
K
--
V
--
P
V
T
--
K
S
A
---
E
--
A
G
T
I
V
A
I
E
E
D
G
F
V
V
A
T
G
N
E
T
-
G
V
K
I
T
E
L
Q
-
P
S
G
K
K
R
M
S
C
S
Q
F
L
R
G
-------------
50
HHSearch
87.70
41%
-49
- C7 -
-
2FMT
-
FMT_ECOLI
A:
[3-303]
S
L
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
-
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
P
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
A
--
S
--
V
I
D
T
A
T
N
A
---
A
--
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
-
I
L
N
L
L
S
L
Q
-
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
------------
52
HHSearch
87.26
39%
-57
- C7 -
-
3TQQ
-
FMT_COXBU
A:
[2-304]
S
L
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
D
-
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
P
F
S
L
R
D
E
V
E
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
-
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
L
S
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
--
R
A
--
T
--
V
V
D
EK
T
D
F
---
E
--
P
G
V
L
V
D
A
D
K
K
G
I
S
I
A
A
G
-
S
G
-
I
L
R
L
H
Q
L
Q
-
L
P
G
K
R
V
C
S
A
G
D
F
I
N
A
H
G
D
----------
4
PsiBlast_PDB
86.81
37%
-52
- C7 -
-
3TQQ
-
FMT_COXBU
A:
[4-310]
--
K
I
V
F
A
G
T
P
Q
F
A
V
P
T
L
R
A
L
I
-
D
S
S
H
R
V
L
A
V
Y
T
Q
P
D
----------
E
S
P
V
K
E
I
A
R
Q
N
E
I
P
I
I
Q
P
F
S
L
R
D
E
V
E
Q
E
K
L
I
A
M
N
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
K
A
L
N
-
A
F
R
L
G
C
V
N
V
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
I
L
A
G
D
R
E
T
G
I
S
I
M
Q
M
N
E
G
L
D
T
G
D
V
L
A
K
S
A
C
V
I
S
S
E
D
T
A
A
D
L
H
D
R
L
S
L
I
G
A
D
L
L
L
E
S
L
A
K
L
E
K
G
D
I
K
L
E
K
Q
D
E
A
S
A
T
Y
A
S
K
I
Q
K
Q
E
A
L
I
D
W
R
K
S
A
V
E
I
A
R
Q
V
R
A
F
-
N
-
P
T
P
I
A
F
T
Y
F
E
G
Q
P
M
R
I
W
--
R
A
--
T
--
V
V
D
--
E
K
T
---
D
FE
P
G
V
L
V
D
A
D
K
K
G
I
S
I
A
A
G
-
S
G
-
I
L
R
L
H
Q
L
Q
-
L
P
G
K
R
V
C
S
A
G
D
F
I
N
A
H
G
D
K
L
I
P
G
K
----
48
HHSearch
85.66
37%
-50
* C7 *
-
5UAI
-
FMT_PSEAE
A:
[12-321]
A
L
R
I
V
F
A
G
T
P
E
F
A
A
E
H
L
K
A
L
L
D
-
T
P
H
R
I
V
A
V
Y
T
Q
P
D
R
P
A
G
R
G
Q
K
L
M
P
S
A
V
K
S
L
A
L
E
H
G
L
P
V
M
Q
P
Q
S
L
R
N
A
E
A
Q
A
E
L
A
A
L
R
A
D
L
M
V
V
V
A
Y
G
L
I
L
P
Q
A
V
L
D
-
I
P
R
L
G
C
I
N
S
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
V
E
A
G
D
A
E
S
G
V
T
V
M
Q
M
E
A
G
L
D
T
G
P
M
L
L
K
V
S
T
P
I
S
A
A
D
T
G
G
S
L
H
D
R
L
A
A
L
G
P
K
A
V
I
E
A
I
A
G
L
A
A
G
T
L
H
G
E
I
Q
D
D
A
L
A
T
Y
A
H
K
L
N
K
D
E
A
R
L
D
W
S
R
P
A
V
E
L
E
R
Q
V
R
A
F
-
T
-
P
W
P
V
C
H
T
S
L
A
D
A
P
L
K
V
L
--
G
A
--
S
--
L
G
Q
--
G
S
G
---
A
--
P
G
T
I
L
E
A
S
R
D
G
L
L
V
A
C
G
-
E
G
-
A
L
R
L
T
R
L
Q
-
L
P
G
G
K
P
L
A
F
A
D
L
Y
N
S
R
R
E
Q
F
A
A
G
Q
V
L
G
-
49
HHSearch
85.15
37%
-49
- C7 -
-
5UAI
-
FMT_PSEAE
D:
[12-321]
A
L
R
I
V
F
A
G
T
P
E
F
A
A
E
H
L
K
A
L
L
D
-
T
P
H
R
I
V
A
V
Y
T
Q
P
D
R
P
A
G
R
G
Q
K
L
M
P
S
A
V
K
S
L
A
L
E
H
G
L
P
V
M
Q
P
Q
S
L
R
N
A
E
A
Q
A
E
L
A
A
L
R
A
D
L
M
V
V
V
A
Y
G
L
I
L
P
Q
A
V
L
D
-
I
P
R
L
G
C
I
N
S
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
V
E
A
G
D
A
E
S
G
V
T
V
M
Q
M
E
A
G
L
D
T
G
P
M
L
L
K
V
S
T
P
I
S
A
A
D
T
G
G
S
L
H
D
R
L
A
A
L
G
P
K
A
V
I
E
A
I
A
G
L
A
A
G
T
L
H
G
E
I
Q
D
D
A
L
A
T
Y
A
H
K
L
N
K
D
E
A
R
L
D
W
S
R
P
A
V
E
L
E
R
Q
V
R
A
F
-
T
-
P
W
P
V
C
H
T
S
L
A
D
A
P
L
K
V
L
--
G
A
--
S
--
L
G
Q
--
G
S
G
---
A
--
P
G
T
I
L
E
A
S
R
D
G
L
L
V
A
C
G
-
E
G
-
A
L
R
L
T
R
L
Q
-
L
P
G
G
K
P
L
A
F
A
D
L
Y
N
S
R
R
E
Q
F
A
A
G
Q
V
L
G
-
6
PsiBlast_PDB
84.85
38%
-44
- C7 -
-
5UAI
-
FMT_PSEAE
A:
[14-321]
--
R
I
V
F
A
G
T
P
E
F
A
A
E
H
L
K
A
L
L
-
D
T
P
H
R
I
V
A
V
Y
T
Q
P
D
R
P
A
G
R
G
Q
K
L
M
P
S
A
V
K
S
L
A
L
E
H
G
L
P
V
M
Q
P
Q
S
L
R
N
A
E
A
Q
A
E
L
A
A
L
R
A
D
L
M
V
V
V
A
Y
G
L
I
L
P
Q
A
V
L
D
-
I
P
R
L
G
C
I
N
S
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
V
E
A
G
D
A
E
S
G
V
T
V
M
Q
M
E
A
G
L
D
T
G
P
M
L
L
K
V
S
T
P
I
S
A
A
D
T
G
G
S
L
H
D
R
L
A
A
L
G
P
K
A
V
I
E
A
I
A
G
L
A
A
G
T
L
H
G
E
I
Q
D
D
A
L
A
T
Y
A
H
K
L
N
K
D
E
A
R
L
D
W
S
R
P
A
V
E
L
E
R
Q
V
R
A
F
-
T
-
P
W
P
V
C
H
T
S
L
A
D
A
P
L
K
V
L
--
G
A
--
S
--
L
G
Q
--
G
S
G
---
A
--
P
G
T
I
L
E
A
S
R
D
G
L
L
V
A
C
G
-
E
G
-
A
L
R
L
T
R
L
Q
L
P
G
G
K
P
-
L
A
F
A
D
L
Y
N
S
R
R
E
Q
F
A
A
G
Q
V
L
G
-
3
PsiBlast_PDB
84.57
40%
-42
- C7 -
-
2FMT
-
FMT_ECOLI
A:
[5-313]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
-
H
N
V
V
G
V
F
T
Q
P
D
R
P
A
G
R
G
K
K
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
P
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
A
--
S
--
V
I
D
--
T
A
T
---
N
AA
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
-
I
L
N
L
L
S
L
Q
-
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
--
5
PsiBlast_PDB
84.55
39%
-57
- C7 -
-
3R8X
5
FMT_YERPE
A:
[9-305]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
G
A
L
L
S
S
-
Q
H
K
I
V
G
V
F
T
Q
P
D
R
P
------
L
T
P
S
P
V
K
I
L
A
E
H
H
G
I
P
V
F
Q
P
K
S
L
R
P
E
E
N
Q
H
L
V
A
D
L
N
A
D
I
M
V
V
V
A
Y
G
L
I
L
P
A
A
V
L
A
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
V
W
A
G
D
E
K
T
G
I
T
I
M
Q
M
D
I
G
L
D
T
G
A
M
L
H
K
I
E
C
A
I
Q
P
E
D
T
S
A
T
L
Y
D
K
L
A
Q
L
G
P
Q
G
L
L
I
T
L
Q
Q
L
A
A
G
T
A
L
A
E
V
Q
N
E
T
Q
A
T
Y
A
E
K
L
S
K
E
E
A
K
L
D
W
T
L
S
A
T
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
V
S
Y
F
I
V
D
E
Q
P
I
K
V
W
--
Q
A
Q
V
L
--
P
A
G
--
E
D
A
---
E
--
P
G
T
I
I
H
A
D
K
H
G
I
Q
V
A
T
A
-
D
G
-
V
L
N
I
T
Q
L
Q
-
P
A
G
K
K
A
M
S
A
A
D
L
L
N
--------------
22
PsiBlast_CBE
84.53
38%
-44
- C7 -
-
5UAI
1
FMT_PSEAE
B:
[14-321]
--
R
I
V
F
A
G
T
P
E
F
A
A
E
H
L
K
A
L
L
-
D
T
P
H
R
I
V
A
V
Y
T
Q
P
D
R
P
A
G
R
G
Q
K
L
M
P
S
A
V
K
S
L
A
L
E
H
G
L
P
V
M
Q
P
Q
S
L
R
N
A
E
A
Q
A
E
L
A
A
L
R
A
D
L
M
V
V
V
A
Y
G
L
I
L
P
Q
A
V
L
D
-
I
P
R
L
G
C
I
N
S
H
A
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
A
V
E
A
G
D
A
E
S
G
V
T
V
M
Q
M
E
A
G
L
D
T
G
P
M
L
L
K
V
S
T
P
I
S
A
A
D
T
G
G
S
L
H
D
R
L
A
A
L
G
P
K
A
V
I
E
A
I
A
G
L
A
A
G
T
L
H
G
E
I
Q
D
D
A
L
A
T
Y
A
H
K
L
N
K
D
E
A
R
L
D
W
S
R
P
A
V
E
L
E
R
Q
V
R
A
F
-
T
-
P
W
P
V
C
H
T
S
L
A
D
A
P
L
K
V
L
--
G
A
--
S
--
L
G
Q
--
G
S
G
---
A
--
P
G
T
I
L
E
A
S
R
D
G
L
L
V
A
C
G
-
E
G
-
A
L
R
L
T
R
L
Q
L
P
G
G
K
P
-
L
A
F
A
D
L
Y
N
S
R
R
E
Q
F
A
A
G
Q
V
L
G
-
51
HHSearch
84.40
41%
-53
- C7 -
-
1FMT
-
FMT_ECOLI
B:
[3-303]
S
L
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
-
S
G
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
P
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
A
--
S
--
V
I
D
TA
T
N
A
---
A
--
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
-
I
L
N
L
L
S
L
Q
-
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
------------
2
PsiBlast_PDB
83.30
40%
-42
- C7 -
-
1FMT
-
FMT_ECOLI
A:
[5-313]
--
R
I
I
F
A
G
T
P
D
F
A
A
R
H
L
D
A
L
L
S
S
G
-
H
N
V
V
G
V
F
T
Q
P
D
R
P
------
L
M
P
S
P
V
K
V
L
A
E
E
K
G
L
P
V
F
Q
P
V
S
L
R
P
Q
E
N
Q
Q
L
V
A
E
L
Q
A
D
V
M
V
V
V
A
Y
G
L
I
L
P
K
A
V
L
E
-
M
P
R
L
G
C
I
N
V
H
G
S
L
L
P
R
W
R
G
A
A
P
I
Q
R
S
L
W
A
G
D
A
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
Y
K
L
S
C
P
I
T
A
E
D
T
S
G
T
L
Y
D
K
L
A
E
L
G
P
Q
G
L
I
T
T
L
K
Q
L
A
D
G
T
A
K
P
E
V
Q
D
E
T
L
V
T
Y
A
E
K
L
S
K
E
E
A
R
I
D
W
S
L
S
A
A
Q
L
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
W
L
E
I
E
G
Q
P
V
K
V
W
--
K
A
--
S
--
V
I
D
--
T
A
T
---
N
AA
P
G
T
I
L
E
A
N
K
Q
G
I
Q
V
A
T
G
-
D
G
-
I
L
N
L
L
S
L
Q
-
P
A
G
K
K
A
M
S
A
Q
D
L
L
N
S
R
R
E
W
F
V
P
G
N
R
L
--
54
HHSearch
80.49
28%
-69
- C7 -
-
2BLN
2
ARNA_ECOLI
A:
[1-296]
-
M
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
-
A
G
Y
E
I
S
A
I
F
T
H
T
D
---------
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
H
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
-
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
S
--
R
--
V
H
P
HA
S
K
A
---
Q
--
P
G
S
V
I
S
V
--
A
P
L
L
I
A
C
G
-
D
G
-
A
L
E
I
V
T
G
Q
-
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
------------
53
HHSearch
80.19
36%
-47
- C7 -
-
3Q0I
1
FMT_VIBCH
A:
[7-307]
S
L
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
-
S
E
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
P
E
N
F
K
S
D
E
S
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
-
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
L
A
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
--
Q
A
--
R
--
V
E
T
RA
V
T
Q
---
T
--
P
G
T
I
I
Q
A
D
K
S
G
I
Y
V
A
T
G
-
Q
D
-
V
L
V
L
E
S
L
Q
-
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
R
------------
57
HHSearch
80.15
28%
-65
- C7 -
-
5J63
2
?
A:
[3-298]
-
M
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
-
A
G
Y
E
I
S
A
I
F
T
H
T
D
N
P
G
E
K
---
A
F
Y
G
S
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
H
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
-
L
A
P
A
G
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
-
A
D
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
S
--
R
--
V
H
P
---
K
A
---
Q
--
P
G
S
V
I
S
V
--
A
P
L
L
I
A
C
G
-
D
G
-
A
L
E
I
V
T
G
Q
-
A
G
D
G
I
T
M
Q
G
S
Q
L
A
Q
T
L
------------
10
PsiBlast_PDB
80.06
29%
-88
- C7 -
-
1YRW
-
ARNA_ECOLI
A:
[2-276]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
-------
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
H
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
S
R
V
H
--
P
-----
K
A
---
Q
--
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
-
A
L
E
I
---------------------------------
8
PsiBlast_PDB
79.46
29%
-77
- C7 -
-
5J63
2
?
A:
[4-278]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
N
P
-
G
E
K
A
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
H
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
S
R
V
H
--
P
-----
K
A
---
Q
--
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
-
A
L
E
I
---------------------------------
7
PsiBlast_PDB
79.43
34%
-38
- C7 -
-
3Q0I
1
FMT_VIBCH
A:
[9-318]
--
R
I
V
F
A
G
T
P
D
F
A
A
R
H
L
A
A
L
L
S
S
E
-
H
E
I
I
A
V
Y
T
Q
P
E
---------
T
A
S
P
V
K
T
L
A
L
E
H
N
V
P
V
Y
Q
P
E
N
F
K
S
D
E
S
K
Q
Q
L
A
A
L
N
A
D
L
M
V
V
V
A
Y
G
L
L
L
P
K
V
V
L
D
-
T
P
K
L
G
C
I
N
V
H
G
S
I
L
P
R
W
R
G
A
A
P
I
Q
R
S
I
W
A
G
D
S
E
T
G
V
T
I
M
Q
M
D
V
G
L
D
T
G
D
M
L
K
I
A
T
L
P
I
E
A
S
D
T
S
A
S
M
Y
D
K
L
A
E
L
G
P
Q
A
L
L
E
C
L
Q
D
I
A
Q
G
T
A
V
A
V
K
Q
D
D
G
L
A
N
Y
A
H
K
L
S
K
E
E
A
R
I
N
W
S
D
A
A
T
H
I
E
R
C
I
R
A
F
-
N
-
P
W
P
M
S
H
F
E
V
A
E
N
S
I
K
V
W
--
Q
A
--
R
---
V
E
--
T
R
A
VTQ
T
--
P
G
T
I
I
Q
A
D
K
S
G
I
Y
V
A
T
G
-
Q
D
-
V
L
V
L
E
S
L
Q
-
I
P
G
K
K
A
L
P
V
Q
D
I
L
N
A
R
A
D
W
F
S
V
G
S
Q
L
S
-
12
PsiBlast_PDB
77.53
29%
-80
- C7 -
-
4WKG
-
ARNA_ECOLI
A:
[2-292]
--
K
T
V
V
F
A
Y
H
D
M
G
C
L
G
I
E
A
L
L
A
A
G
-
Y
E
I
S
A
I
F
T
H
T
D
N
P
-----
F
Y
G
S
--
V
A
R
L
A
A
E
R
G
I
P
V
Y
A
P
D
N
V
N
H
P
L
W
V
E
R
I
A
Q
L
S
P
D
V
I
F
S
F
Y
Y
R
H
L
I
Y
D
E
I
L
Q
L
A
P
A
G
-
A
F
N
L
H
G
S
L
L
P
K
Y
R
G
R
A
P
L
N
W
V
L
V
N
G
E
T
E
T
G
V
T
L
H
R
M
V
K
R
A
D
A
G
A
I
V
A
Q
L
R
I
A
I
A
P
D
D
I
A
I
T
L
H
H
K
L
C
H
A
A
R
Q
L
L
E
Q
T
L
P
A
I
K
H
G
N
I
L
E
I
A
Q
R
E
N
E
A
T
C
F
G
R
R
T
P
D
D
S
F
L
E
W
H
K
P
A
S
V
L
H
N
M
V
R
A
V
A
D
-
P
W
P
G
A
F
S
Y
V
G
N
Q
K
F
T
V
W
--
S
S
--
R
V
H
P
H
A
--
S
K
A
---
Q
--
P
G
S
V
I
S
V
A
P
--
L
L
I
A
C
G
-
D
G
-
A
L
E
I
---------------------------------