@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1604: (2018-01-15 )
MKKFVAELIGTFMLVFVGTGAVVFGNGLDGLGHLGIAFAFGLAIVVAAYSIGTVSGAHLNPAVSIAMFVNKRLSSSELVNYILGQVVGAFIASGAVFFLLANSGMSTASLGENALANGVTVFGGFLFEVIATFLFVLVIMTVTSESKGNGAIAGLVIGLSLMAMILVGLKITGLSVNPARSLAPAVLVGGAALQQVWIFILAPIAGGVLAALVAKNFLGTEE
Atome Classification :
(22 SA)
.........10........20....-------...-..--30-----------..-.--------------.....40........50........60........70........80........--------90........--100.------...--...---110----.......120.......130.......140......-.-150--.......160.......170.......180..---..---...190.-....-..200.......210.......220
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
K
F
V
A
E
L
I
G
T
F
M
L
V
F
VGT
G
-
A
V
V
F-------GNG-LD--
G
L
-----------
G
H
-
L
--------------
G
I
A
F
A
F
G
L
A
I
V
V
A
A
Y
SIGTVSGAHLN
P
A
V
S
I
A
M
F
V
N
KRL
S
S
S
E
L
V
N
Y
I
L
G
Q
V
V
G
A
--------
F
I
AS
G
A
V
F
F
L
--
L
ANS------GMS--
T
A
S---LG
E
----
N
A
L
ANG
V
T
V
F
G
G
F
L
F
E
V
I
A
T
F
L
F
V
L
V
I
M
TVTSESKG-N-
G
A
I
--
A
G
L
V
I
G
L
S
L
M
A
M
I
L
VG
L
K
I
TGLSVN
P
A
R
SL
A
P
---
A
V
---
L
V
G
G
A
A
L
-
Q
Q
V
W
-
I
F
IL
A
P
IA
G
G
V
L
A
A
L
V
A
K
N
FLGTEE
65
HHSearch
83.52
40%
-123
- C8 -
-
3LLQ
-
AQPZ2_AGRFC
A:
[2-228]
G
R
K
L
L
A
E
F
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
F
-------
A
A
A
-
F
P
EL
G
I
-----------
G
F
-
T
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
Y
A
V
G
G
I
S
G
G
H
F
N
P
A
V
S
V
G
L
T
V
A
G
R
F
P
A
S
S
L
V
P
Y
V
I
A
Q
V
A
G
A
--------
I
V
A
A
A
A
L
Y
V
I
--
A
T
G
K
A-----
G
I
D
--
L
G
G
---
F
A
S
N
G
Y
G
E
H
S
P
G
G
Y
S
L
V
S
A
L
L
I
E
I
I
L
T
A
F
F
L
I
V
I
L
G
S
T
H
G
R
-
V
-
P
-
A
G
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
G
Q
---
A
L
---
F
V
G
G
W
A
L
-
Q
Q
L
W
-
L
F
W
L
A
P
I
V
G
G
A
A
G
A
V
I
W
K
L
F
G
E
K
D
-
64
HHSearch
82.82
40%
-127
- C8 -
-
3LLQ
-
AQPZ2_AGRFC
B:
[2-227]
G
R
K
L
L
A
E
F
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
F
-------
A
A
A
-
F
P
EL
G
I
-----------
G
F
-
T
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
Y
A
V
G
G
I
S
G
G
H
F
N
P
A
V
S
V
G
L
T
V
A
G
R
F
P
A
S
S
L
V
P
Y
V
I
A
Q
V
A
G
A
--------
I
V
A
A
A
A
L
Y
V
I
--
A
T
G
K
A-----
G
I
D
--
L
G
G
---
F
A
S
N
G
Y
G
E
H
S
P
G
G
Y
S
L
V
S
A
L
L
I
E
I
I
L
T
A
F
F
L
I
V
I
L
G
S
T
H
G
R
-
V
-
P
-
A
G
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
G
Q
---
A
L
---
F
V
G
G
W
A
L
-
Q
Q
L
W
-
L
F
W
L
A
P
I
V
G
G
A
A
G
A
V
I
W
K
L
F
G
E
K
--
1
PsiBlast_PDB
81.29
39%
-119
- C8 -
-
3LLQ
-
AQPZ2_AGRFC
A:
[3-224]
-
R
K
L
L
A
E
F
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
F
-------
A
A
A
-
F
P
EL
G
I
-----------
G
F
-
T
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
Y
A
V
G
G
I
S
G
G
H
F
N
P
A
V
S
V
G
L
T
V
A
G
R
F
P
A
S
S
L
V
P
Y
V
I
A
Q
V
A
G
A
--------
I
V
A
A
A
A
L
Y
V
I
--
A
T
G
K
AGIDLG
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
L
V
S
A
L
L
I
E
I
I
L
T
A
F
F
L
I
V
I
L
G
S
T
-
H
G
R
V
-
P
-
A
G
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
G
Q
---
A
L
---
F
V
G
G
W
A
L
-
Q
Q
L
W
-
L
F
W
L
A
P
I
V
G
G
A
A
G
A
V
I
W
K
L
F
-----
25
PsiBlast_CBE
80.91
38%
0
- C- -
-
2ABM
5
AQPZ_ECOLI
B:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
IVAAALLY
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
24
PsiBlast_CBE
80.91
38%
0
- C- -
-
2ABM
2
AQPZ_ECOLI
C:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
IVAAALLY
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
23
PsiBlast_CBE
80.91
38%
0
- C- -
-
2ABM
4
AQPZ_ECOLI
E:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
IVAAALLY
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
22
PsiBlast_CBE
80.91
38%
0
- C- -
-
2ABM
5
AQPZ_ECOLI
F:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
IVAAALLY
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
21
PsiBlast_CBE
80.91
38%
0
- C- -
-
2ABM
3
AQPZ_ECOLI
G:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
IVAAALLY
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
3
PsiBlast_PDB
80.91
38%
0
- C- -
-
2ABM
5
AQPZ_ECOLI
A:
[3-208]
-
R
K
L
A
A
E
C
F
G
T
F
W
L
V
F
G
G
C
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
I
V
A
A
A
L
L
Y
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
40
PsiBlast_CBE
79.28
33%
-151
- C8 -
-
3M9I
7
MIP_SHEEP
A:
[4-216]
W
R
A
I
F
A
E
F
F
A
T
L
F
Y
V
F
F
G
L
G
-
A
S
L
---------
R
W
-
A
P
--
G
P
-----------
L
H
V
L
--------------
Q
V
A
L
A
F
G
L
A
L
A
T
L
V
Q
A
V
G
H
I
S
G
A
H
V
N
P
A
V
T
F
A
F
L
V
G
S
Q
M
S
L
L
R
A
I
C
Y
V
V
A
Q
L
L
G
A
---------
V
A
G
A
A
V
L
Y
S
--
V
T
P
P
------
A
V
R
---
G
N
---
L
A
L
----
N
T
L
H
P
G
V
S
V
G
Q
A
T
I
V
E
I
F
L
T
L
Q
F
V
L
C
I
F
A
T
Y
D
E
R
R
--
N
-
G
R
L
GS
V
A
L
A
V
G
F
S
L
T
L
G
H
L
F
G
M
Y
Y
T
G
A
G
M
N
P
A
R
S
F
A
P
---
A
I
---
L
T
R
N
--
F
-
T
N
H
W
-
V
Y
W
V
G
P
V
I
G
A
G
L
G
S
L
L
-
Y
D
F
L
----
19
PsiBlast_PDB
78.62
35%
-158
- C8 -
-
4NEF
-
AQP2_HUMAN
A:
[11-218]
-
R
A
V
F
A
E
F
L
A
T
L
L
F
V
F
F
G
L
G
S
A
L
N
W
-------
P
Q
A
-
L
P
--
S
V
--------------
L
--------------
Q
I
A
M
A
F
G
L
G
I
G
T
L
V
Q
A
L
G
H
I
S
G
A
H
I
N
P
A
V
T
V
A
C
L
V
G
C
H
V
S
V
L
R
A
A
F
Y
V
A
A
Q
L
L
G
A
---------
V
A
G
A
A
L
L
H
E
--
I
T
P
A
------
D
I
R
---
G
D
---
L
A
V
----
N
A
L
S
N
S
T
T
A
G
Q
A
V
T
V
E
L
F
L
T
L
Q
L
V
L
C
I
F
A
S
T
D
E
R
R
G
E
N
-
P
G
T
--
P
A
L
S
I
G
F
S
V
A
L
G
H
L
L
G
I
H
Y
T
G
C
S
M
N
P
A
R
S
L
A
P
---
A
V
---
V
T
G
--
K
F
-
D
D
H
W
-
V
F
W
I
G
P
L
V
G
A
I
L
G
S
L
L
---------
11
PsiBlast_PDB
78.11
38%
-112
- C8 -
-
3NE2
3
AQPM_ARCFU
A:
[7-245]
-
K
R
F
T
A
E
V
V
G
T
F
I
L
V
F
F
G
P
G
-
A
A
V
I
T
L
M
I
---
A
N
G
-
A
D
--
K
P
-----------
N
E
-
F
NIGIGALGGL
G
D
W
F
A
I
G
M
A
F
A
L
A
I
A
A
V
I
Y
S
L
G
R
I
S
G
A
H
I
N
P
A
V
T
I
A
L
W
S
I
G
R
F
P
G
R
E
V
V
P
Y
I
V
A
Q
F
I
G
A
----------
A
L
G
S
L
L
F
L
A
C
V
G
P
A
------
A
A
T
--
V
G
G
---
L
G
A
----
T
A
P
F
P
G
I
G
Y
G
Q
A
I
L
T
E
A
I
G
T
F
L
L
M
L
V
I
M
G
V
A
V
D
E
R
A
-
P
-
P
G
F
--
A
G
L
V
I
G
L
T
V
G
G
I
I
T
T
I
G
N
I
T
G
S
S
L
N
P
A
R
T
F
G
P
---
Y
L
G
D
S
L
M
G
I
N
L
W
-
Q
Y
F
P
-
I
Y
V
I
G
P
I
V
G
A
V
A
A
A
W
L
-
Y
N
Y
L
A
K
--
75
HHSearch
77.43
36%
-145
- C8 -
-
5C5X
1
AQP5_HUMAN
G:
[11-228]
L
K
A
V
F
A
E
F
L
A
T
L
I
F
V
F
F
G
L
G
-
S
A
L
K
-------
W
P
S
--
A
--
L
P
-----------
T
I
-
L
--------------
Q
I
A
L
A
F
G
L
A
I
G
T
L
A
Q
A
L
G
P
V
S
G
G
H
I
N
P
A
I
T
L
A
L
L
V
G
N
Q
I
S
L
L
R
A
F
F
Y
V
A
A
Q
L
V
G
A
--------
I
A
G
A
G
I
L
Y
G
V
--
A
P
L
N
------
A
R
----
G
N
---
L
A
V
----
N
A
L
N
N
N
T
T
Q
G
Q
A
M
V
V
E
L
I
L
T
F
Q
L
A
L
C
I
F
A
S
T
D
S
R
R
T
-
E
P
V
G
S
--
P
A
L
S
I
G
L
S
V
T
L
G
H
L
V
G
I
Y
F
T
G
C
S
M
N
P
A
R
S
F
G
P
---
A
V
---
V
M
N
--
R
F
S
P
A
H
W
-
V
F
W
V
G
P
I
V
G
A
V
L
A
A
I
L
Y
F
Y
L
L
F
P
N
-
59
HHSearch
77.40
33%
-138
* C8 *
-
4NEF
-
AQP2_HUMAN
A:
[10-226]
S
R
A
V
F
A
E
F
L
A
T
L
L
F
V
F
F
G
L
G
-
S
A
L
N
-------
W
P
Q
-
A
---
L
P
-----------
S
V
-
L
--------------
Q
I
A
M
A
F
G
L
G
I
G
T
L
V
Q
A
L
G
H
I
S
G
A
H
I
N
P
A
V
T
V
A
C
L
V
G
C
H
V
S
V
L
R
A
A
F
Y
V
A
A
Q
L
L
G
A
--------
V
A
G
A
A
L
L
H
E
I
--
T
P
A
D
------
I
R
----
G
D
---
L
A
V
----
N
A
L
S
N
S
T
T
A
G
Q
A
V
T
V
E
L
F
L
T
L
Q
L
V
L
C
I
F
A
S
T
D
E
R
R
G
-
E
N
P
G
T
--
P
A
L
S
I
G
F
S
V
A
L
G
H
L
L
G
I
H
Y
T
G
C
S
M
N
P
A
R
S
L
A
P
---
A
V
---
V
T
G
--
K
F
-
D
D
H
W
-
V
F
W
I
G
P
L
V
G
A
I
L
G
S
L
L
Y
N
Y
V
L
F
P
P
-
13
PsiBlast_PDB
76.98
33%
-143
- C8 -
-
2F2B
1
AQPM_METTM
A:
[6-245]
-
K
R
C
I
A
E
F
I
G
T
F
I
L
V
F
F
G
A
G
-
S
A
A
V
T
L
M
I
A
SG
G
T
S
-
P
N
--
P
F
NIGIGLLGGL
G
D
W
-
V
--------------
A
I
G
L
A
F
G
F
A
I
A
A
S
I
Y
A
L
G
N
I
S
G
C
H
I
N
P
A
V
T
I
G
L
W
S
V
K
K
F
P
G
R
E
V
V
P
Y
I
I
A
Q
L
L
G
A
--------
A
F
G
S
---
F
I
F
--
L
Q
C
A
------
G
I
G
--
A
A
T
V
GG
L
G
A
----
T
A
P
F
P
G
I
S
Y
W
Q
A
M
L
A
E
V
V
G
T
F
L
L
M
I
T
I
M
G
I
A
V
D
E
R
A
-
P
-
K
G
F
--
A
G
I
I
I
G
L
T
V
A
G
I
I
T
T
L
G
N
I
S
G
S
S
L
N
P
A
R
T
F
G
P
Y
L
N
D
M
---
I
F
A
G
T
D
L
-
W
N
Y
Y
S
I
Y
V
I
G
P
I
V
G
A
V
L
A
A
L
T
Y
Q
-
Y
L
T
S
--
31
PsiBlast_CBE
76.70
38%
-113
- C8 -
-
3NE2
1
AQPM_ARCFU
G:
[7-245]
-
K
R
F
T
A
E
V
V
G
T
F
I
L
V
F
F
G
P
G
-
A
A
V
I
TLMI---
A
N
G
-
A
D
--
K
P
-----------
N
E
-
F
NIGIGALGGLGDWF
A
I
G
M
A
F
A
L
A
I
A
A
V
I
Y
S
L
G
R
I
S
G
A
H
I
N
P
A
V
T
I
A
L
W
S
I
G
R
F
P
G
R
E
V
V
P
Y
I
V
A
Q
F
I
G
A
----------
A
L
G
S
L
L
F
L
AC
V
G
P
A
------
A
A
T
--
V
G
G
---
L
G
A
----
T
A
P
F
P
G
I
G
Y
G
Q
A
I
L
T
E
A
I
G
T
F
L
L
M
L
V
I
M
G
V
A
V
D
E
R
A
-
P
-
P
G
F
--
A
G
L
V
I
G
L
T
V
G
G
I
I
T
T
I
G
N
I
T
G
S
S
L
N
P
A
R
T
F
G
P
---
Y
L
GDS
L
M
G
I
N
L
W
-
Q
Y
F
P
-
I
Y
V
I
G
P
I
V
G
A
V
A
A
A
W
L
-
Y
N
Y
L
A
K
--
67
HHSearch
76.67
31%
-146
- C8 -
-
3M9I
7
MIP_SHEEP
A:
[4-220]
W
R
A
I
F
A
E
F
F
A
T
L
F
Y
V
F
F
G
L
G
-
A
S
L
R
-------
W
A
P
-
G
---
P
L
-----------
H
V
-
L
--------------
Q
V
A
L
A
F
G
L
A
L
A
T
L
V
Q
A
V
G
H
I
S
G
A
H
V
N
P
A
V
T
F
A
F
L
V
G
S
Q
M
S
L
L
R
A
I
C
Y
V
V
A
Q
L
L
G
A
--------
V
A
G
A
A
V
L
Y
S
V
--
T
P
P
A
------
V
R
----
G
N
---
L
A
L
----
N
T
L
H
P
G
V
S
V
G
Q
A
T
I
V
E
I
F
L
T
L
Q
F
V
L
C
I
F
A
T
Y
D
E
R
R
N
-
G
R
L
G
S
--
V
A
L
A
V
G
F
S
L
T
L
G
H
L
F
G
M
Y
Y
T
G
A
G
M
N
P
A
R
S
F
A
P
---
A
I
---
L
T
R
--
N
F
-
T
N
H
W
-
V
Y
W
V
G
P
V
I
G
A
G
L
G
S
L
L
Y
D
F
L
L
F
P
R
-
77
HHSearch
76.59
36%
-149
- C8 -
-
3D9S
1
AQP5_HUMAN
D:
[12-228]
L
K
A
V
F
A
E
F
L
A
T
L
I
F
V
F
F
G
L
G
-
S
A
L
K
-------
W
P
S
-
A
---
L
P
-----------
T
I
-
L
--------------
Q
I
A
L
A
F
G
L
A
I
G
T
L
A
Q
A
L
G
P
V
S
G
G
H
I
N
P
A
I
T
L
A
L
L
V
G
N
Q
I
S
L
L
R
A
F
F
Y
V
A
A
Q
L
V
G
A
--------
I
A
G
A
G
I
L
Y
G
V
--
A
P
L
N
------
A
R
----
G
N
---
L
A
V
----
N
A
L
N
N
N
T
T
Q
G
Q
A
M
V
V
E
L
I
L
T
F
Q
L
A
L
C
I
F
A
S
T
D
S
R
R
T
-
S
P
V
G
S
--
P
A
L
S
I
G
L
S
V
T
L
G
H
L
V
G
I
Y
F
T
G
C
S
M
N
P
A
R
S
F
G
P
---
A
V
---
V
M
N
--
R
F
S
P
A
H
W
-
V
F
W
V
G
P
I
V
G
A
V
L
A
A
I
L
Y
F
Y
L
L
F
P
--
34
PsiBlast_CBE
76.50
38%
-112
- C8 -
-
3NE2
2
AQPM_ARCFU
D:
[7-245]
-
K
R
F
T
A
E
V
V
G
T
F
I
L
V
F
F
G
P
G
-
A
A
V
I
TLMI---
A
N
G
-
A
D
--
K
P
-----------
N
E
-
F
NIGIGALGGLGDWF
A
I
G
M
A
F
A
L
A
I
A
A
V
I
Y
S
L
G
R
I
S
G
A
H
I
N
P
A
V
T
I
A
L
W
S
I
G
R
F
P
G
R
E
V
V
P
Y
I
V
A
Q
F
I
G
A
----------
A
L
G
S
L
L
F
L
AC
V
G
P
A
------
A
A
T
--
V
G
G
---
L
G
A
----
T
A
P
F
P
G
I
G
Y
G
Q
A
I
L
T
E
A
I
G
T
F
L
L
M
L
V
I
M
G
V
A
V
D
E
R
A
-
P
-
P
G
F
--
A
G
L
V
I
G
L
T
V
G
G
I
I
T
T
I
G
N
I
T
G
S
S
L
N
P
A
R
T
F
G
P
---
Y
L
GDS
L
M
G
I
N
L
W
-
Q
Y
F
P
-
I
Y
V
I
G
P
I
V
G
A
V
A
A
A
W
L
-
Y
N
Y
L
A
K
--
63
HHSearch
76.29
34%
-119
- C8 -
-
2O9G
2
AQPZ_ECOLI
A:
[5-233]
F
R
K
L
A
A
E
S
F
G
T
F
W
L
V
F
G
G
S
G
-
S
A
V
L
-------
A
A
G
F
P
E
L-
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
--------
I
V
A
A
A
L
L
Y
L
I
--
A
S
G
K
T-----
G
F
D
AA
A
S
G
---
F
A
S
N
G
Y
G
E
H
S
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
-
A
-
P
-
A
G
F
--
A
P
I
A
I
G
L
A
C
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
W
V
V
P
I
V
G
G
I
I
G
G
L
I
Y
R
T
L
L
E
K
R
-
5
PsiBlast_PDB
71.60
38%
-123
- C8 -
-
2O9D
3
AQPZ_ECOLI
A:
[6-211]
-
R
K
L
A
A
E
S
F
G
T
F
W
L
V
F
G
G
S
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
I
V
A
A
A
L
L
Y
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
C
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------
10
PsiBlast_PDB
71.42
37%
-120
- C8 -
-
2O9G
2
AQPZ_ECOLI
A:
[6-211]
-
R
K
L
A
A
E
S
F
G
T
F
W
L
V
F
G
G
S
G
-
S
A
V
L
-------
A
A
G
-
F
P
EL
G
I
-----------
G
F
-
A
--------------
G
V
A
L
A
F
G
L
T
V
L
T
M
A
F
A
V
G
H
I
S
G
G
H
F
N
P
A
V
T
I
G
L
W
A
G
G
R
F
P
A
K
E
V
V
G
Y
V
I
A
Q
V
V
G
G
I
V
A
A
A
L
L
Y
L
I
A
S
G
K
T
G
F
D
--
A
A
A
S
------
G
F
A
--
S
N
G
---
Y
G
E
----
H
S
-
P
G
G
Y
S
M
L
S
A
L
V
V
E
L
V
L
S
A
G
F
L
L
V
I
H
G
A
T
D
K
F
A
P
-
A
-
G
-
F
--
A
P
I
A
I
G
L
A
C
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
A
V
---
A
I
---
F
Q
G
G
W
A
L
-
E
Q
L
W
-
F
F
-----------------------