@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1656: (2018-01-16 )
MQNKQEQWTVLKRLMSYLKPYGLLTFLALSFLLATTVIKSVIPLVASHFIDQYLSNLNQLAVTVLLVYYGLYILQTVVQYVGNLLFARVSYSIVRDIRRDAFANMEKLGMSYFDKTPAGSIVSRLTNDTETISDMFSGILSSFISAVFIFLTTLYTMLVLDFRLTALVLLFLPLIFLLVNLYRKKSVKIIEKTRSLLSDINSKLAENIEGIRIIQAFNQEKRLQAEFDEINQEHLAYANRSVALDALFLRPAMSLLKLLGYAVLMTYFGYRGLSIGITAGTMYAFIQYINRLFDPLIEVTQNFSTLQTSMVSAGRVFALIDERTYEPLQENGQAKVKEGNIRFEHVCFSYDGKHPILDDISFSVNKGETIAFVGHTGSGKSSIINVLMRFYEFQSGRVLLDDVDIRDFSQEELRKNIGLVLQEPFLYHGTIKSNIAMYQEISDEQVQAAAAFVDADSFIQELPQGYDSPVSERGSSFSTGQRQLLAFARTVASQPKILILDEATANIDSETESLVQASLAKMRQGRTTIAIAHRLSTIQDANCIYVLDKGRIIESGTHEELLTLGGTYHKMYSLQAGAMAYTL
Atome Classification :
(30 SA)
.........10........20..-......30........40........50--------.-....--------...--------60---...-......70........80........90........100.......110.......120.......130..-.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320........330-.-..----....--.340.......350..-------..-.-----....360.......370.......380.......390.......400.....--..410.......420...--....430------....--.--.--..440-........450.......460.......470.......480.......490....-.-..500.......510.......520..-----.....530......-.540.......550.......560.....-..570.......580.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQN
K
Q
E
Q
W
T
V
L
K
R
L
M
S
Y
L
K
P
Y
G
L
-
L
T
F
L
A
L
S
F
L
L
A
T
T
V
I
K
S
V
I
P
L
V
A
S
H
F
I
D
--------
Q
-
Y
L
S
N
--------
L
N
Q
--------
L
----
A
V
T
-
V
L
L
V
Y
Y
G
L
Y
I
L
Q
T
V
V
Q
Y
V
G
N
L
L
F
A
R
V
S
Y
S
I
V
R
D
I
R
R
D
A
F
A
N
M
E
K
L
G
M
S
Y
FDKTP
A
G
S
I
V
S
R
LTN
D
T
E
T
I
S
D
-
M
F
S
G
I
L
S
S
F
I
S
A
V
F
I
F
L
T
T
L
Y
T
M
L
V
L
D
F
R
L
T
A
L
V
L
L
F
L
P
L
I
F
L
L
V
N
L
Y
R
K
K
S
V
K
I
I
E
K
T
R
S
L
L
S
D
I
N
S
K
L
A
E
NIE
G
I
R
I
I
Q
A
FN
Q
E
K
R
L
Q
A
E
F
D
EI
N
Q
E
H
L
A
YANR
S
V
A
L
D
A
L
F
L
R
P
A
M
S
L
L
K
L
L
G
Y
A
V
L
M
T
Y
FGYRG
L
S
I
G
I
T
A
G
T
M
Y
A
F
I
Q
Y
I
N
R
L
F
D
P
L
I
E
V
T
Q
N
F
S
T
L
Q
T
S
M
VSAG
R
V
F
A
L
ID-ERTY
E
P
L
Q
EN--G-
Q
A
----
K
VKE--G
N
I
R
F
E
H
V
C
F
SY--DG-------KH-P-----I
L
D
D
I
S
F
SVNKG
E
T
I
A
F
V
GHTGS
G
K
S
S
I
I
N
V
L
M
R
F
Y
EFQSG
R
V
L
L
D
DVDIRD--F
S
Q
E
E
L
R
K
NI
G
L
VLQEP
F
--
L
YHGTI-------KS
N
I
--
A
--
M
--
Y
Q
E-I-
S
D
E
Q
V
Q
A
A
A
A
FV
D
A
D
S
F
I
Q
E
L
P
QGYDS
P
V
S
ERGSSFS
T
G
Q
R
Q
L
L
A
F
A
R
T
VASQP
K
-
I
-
L
I
L
DEATANID
S
E
T
E
S
L
V
Q
A
S
L
A
K
M
RQ-----GR
T
T
I
A
I
A
HRLSTI-QDA
N
C
I
Y
V
LDK
G
R
I
IESGT
H
E
E
L
L
T
LGG
T
-
Y
H
K
M
Y
S
LQAG
A
M
A
YTL
100
HHSearch
84.54
36%
-60
- C2 -
-
5MKK
-
?
A:
[10-591]
------
D
R
A
L
F
A
R
I
L
R
Y
V
W
P
Y
R
L
-
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
--------
L
-
A
L
V
P
--------
T
E
P
R
P
L
A
E
R
FH
L
----
L
L
W
-
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
-
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
-
F
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
-
T
E
E
E
L
K
D
P
E
D
--
P
T
P
I
----
R
G
F
R
--
G
E
V
E
F
R
D
V
W
L
A
Y
--
T
P
KGVEPTE
K
D
-
W
-----
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
--
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
--
L
F
S
G
T
V
-------
L
D
N
L
--
R
--
L
--
F
D
P
S
V
-
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
I
L
-
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
-----
G
R
T
S
L
I
I
A
H
R
L
S
T
I
-
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
G
Y
-
Y
A
A
L
------------
8
PsiBlast_PDB
84.00
35%
-59
- C2 -
-
5MKK
-
?
A:
[16-595]
------------
R
I
L
R
Y
V
W
P
Y
R
L
-
Q
V
V
L
A
L
L
F
L
L
V
V
T
L
A
A
A
A
T
P
L
F
F
K
W
A
I
D
L
A
LVPTEP
R
-
P
L
A
E
--------
R
F
H
--------
L
----
L
L
W
-
I
S
L
G
F
L
A
V
R
A
V
H
F
A
A
T
Y
G
E
T
Y
L
I
Q
W
V
G
Q
R
V
L
F
D
L
R
S
D
L
F
A
K
L
M
R
L
H
P
G
F
Y
D
R
N
P
V
G
R
L
M
T
R
V
T
S
D
V
D
A
I
N
Q
-
F
I
T
G
G
L
V
G
V
I
A
D
L
F
T
L
V
G
L
L
G
F
M
L
F
L
S
P
K
L
T
L
V
V
L
L
V
A
P
V
L
L
A
V
T
T
W
V
R
L
G
M
R
S
A
Y
R
E
M
R
L
R
L
A
R
V
N
A
A
L
Q
E
N
L
S
G
V
E
T
I
Q
L
F
V
K
E
R
E
R
E
E
K
F
D
R
L
N
R
D
L
F
R
A
W
V
E
I
I
R
W
F
A
L
F
F
-
P
V
V
G
F
L
G
D
F
A
V
A
S
L
V
Y
Y
G
G
G
E
V
V
R
G
A
V
S
L
G
L
L
V
A
F
V
D
Y
T
R
Q
L
F
Q
P
L
Q
D
L
S
D
K
F
N
L
F
Q
G
A
M
A
S
A
E
R
I
F
G
V
L
D
T
E
E
E
L
K
D
P
E
D
P
--
T
-
P
I
----
R
G
F
R
--
G
E
V
E
F
R
D
V
W
L
A
Y
TP
K
G
-------
V
E
-
P
TEKDW
V
L
K
G
V
S
F
R
V
R
P
G
E
K
V
A
L
V
G
A
T
G
A
G
K
T
S
V
V
S
L
I
A
R
F
Y
D
P
Q
R
G
C
V
F
L
D
G
V
D
V
R
R
--
Y
R
Q
E
E
L
R
R
H
V
G
I
V
L
Q
E
P
F
--
L
F
S
G
T
V
-------
L
D
N
L
--
R
--
L
--
F
D
P
S
V
-
P
P
E
R
V
E
E
V
A
R
F
L
G
A
H
E
F
I
L
R
L
P
K
G
Y
Q
T
V
L
G
E
R
G
A
G
L
S
T
G
E
K
Q
L
L
A
L
V
R
A
L
L
A
S
P
D
-
I
L
L
I
L
D
E
A
T
A
S
V
D
S
E
T
E
K
R
L
Q
E
A
L
Y
K
A
M
E
-----
G
R
T
S
L
I
I
A
H
R
L
S
T
I
-
R
H
V
D
R
I
L
V
F
R
K
G
R
L
V
E
E
G
S
H
E
E
L
L
A
K
G
G
Y
-
Y
A
A
L
Y
R
L
Q
--------
7
PsiBlast_PDB
78.21
34%
-33
- C2 -
-
4A82
-
Y1866_STAAM
A:
[1-576]
---------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
HALT
T
D
E
K
V
H
H
--------
L
----
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
-
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
-
D
Y
D
I
--
K
N
--
G
-
V
G
AQPI
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N-
D
N
-------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
-
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
Q
--------
6
PsiBlast_PDB
77.92
34%
-33
- C2 -
-
2ONJ
2
Y1866_STAAM
A:
[1-576]
---------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
HALT
T
D
E
K
V
H
H
--------
L
----
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
-
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
-
D
Y
D
I
--
K
N
--
G
-
V
G
AQPI
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N-
D
N
-------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
-
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
Q
--------
5
PsiBlast_PDB
77.86
34%
-33
- C2 -
-
2HYD
2
Y1866_STAAM
A:
[1-576]
---------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
HALT
T
D
E
K
V
H
H
--------
L
----
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
-
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
-
D
Y
D
I
--
K
N
--
G
-
V
G
AQPI
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N-
D
N
-------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
-
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
Q
--------
94
HHSearch
77.78
35%
-36
- C2 -
-
4A82
-
Y1866_STAAM
B:
[3-575]
-----------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
--------
H
A
L
TTDE----
K
VHHL
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
-
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
Y
S
-
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
D
Y
D
I
K
N
G
V
G
A-
Q
-
P
I
----
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
D
N------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
T
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
---------
93
HHSearch
76.29
27%
-82
- C2 -
-
5MKK
-
?
B:
[7-568]
--------
P
L
L
R
R
L
W
P
Y
V
G
R
Y
R
W
-
R
Y
L
W
A
V
L
A
G
L
V
S
I
F
F
F
V
L
T
P
Y
F
L
R
L
A
V
D
--------
A
-
V
Q
A
G
--------
R
G
--------------
F
G
V
-
Y
A
L
A
I
V
A
S
A
A
L
S
G
L
L
S
Y
A
M
R
R
L
A
V
V
A
S
R
Q
V
E
Y
D
L
R
R
D
L
L
H
H
L
L
T
L
D
R
D
F
Y
H
K
H
R
V
G
D
L
M
N
R
L
N
T
D
L
S
A
V
R
E
-
M
V
G
P
G
I
L
M
G
S
R
L
S
F
L
V
L
L
A
F
L
S
M
Y
A
V
N
A
R
L
A
F
Y
L
T
L
I
L
P
G
I
F
L
A
M
R
F
L
L
R
L
I
D
R
R
Y
R
E
A
Q
E
V
F
D
R
I
S
T
L
A
Q
E
A
F
S
G
I
R
V
V
K
G
Y
A
L
E
R
R
M
V
A
W
F
Q
D
L
N
R
L
Y
V
E
K
S
L
A
L
A
R
V
E
G
P
L
-
H
A
L
L
G
F
L
M
G
F
A
F
L
T
V
L
W
A
G
G
A
M
V
V
R
G
E
L
S
V
G
E
L
V
Q
F
N
A
Y
L
A
Q
L
T
W
P
I
L
G
L
G
W
V
M
A
L
Y
Q
R
G
L
T
S
L
R
R
L
F
E
L
L
D
-
E
K
P
A
I
R
D
E
D
P
LP
L
-
A
L
----
E
D
L
S
--
G
E
V
R
F
E
G
V
G
L
K
R
--
D
G
--------
R
-
W
-----
L
L
R
G
L
T
L
T
I
P
E
G
M
T
L
G
I
T
G
R
T
G
S
G
K
S
L
L
A
A
L
V
P
R
L
L
D
P
S
E
G
R
V
Y
V
G
G
H
E
A
R
R
--
I
P
L
A
V
L
R
K
A
V
G
V
A
P
Q
E
P
F
--
L
F
S
E
T
I
-------
L
E
N
I
--
A
--
F
--
G
L
D
E
V
-
D
R
E
R
V
E
W
A
A
R
L
A
G
I
H
E
E
I
L
A
F
P
K
G
Y
E
T
V
L
G
E
R
G
I
T
L
S
G
G
Q
R
Q
R
V
A
L
A
R
A
L
A
K
R
P
K
-
I
-
L
I
L
D
D
A
L
S
A
V
D
A
E
T
E
A
R
I
L
Q
G
L
K
T
V
L
G
-----
K
Q
T
T
L
L
I
S
H
R
T
A
A
L
-
R
H
A
D
W
I
I
V
L
D
G
G
R
I
V
E
E
G
T
H
E
S
L
L
Q
A
G
G
L
-
Y
A
E
M
------------
21
PsiBlast_CBE
76.07
34%
-32
- C2 -
-
2ONJ
2
Y1866_STAAM
B:
[1-576]
---------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
HALTTDEK
V
H
H
--------
L
----
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
-
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
-
D
Y
D
I
--
K
N
--
G
-
V
G
AQPI
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N-
D
N
-------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
-
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
Q
--------
1
PsiBlast_PDB
75.47
32%
-35
- C2 -
-
3QF4
1
Y288_THEMA
B:
[25-592]
----------
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
V
F
V
P
R
--------
R
F
D
--------
L
----
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
S
Q
Y
G
------
22
PsiBlast_CBE
75.28
34%
-31
- C2 -
-
2HYD
2
Y1866_STAAM
B:
[1-576]
---------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
-
R
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
--------
G
-
V
I
N
N
HALTTDEK
V
H
H
--------
L
----
T
I
A
-
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
-
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
S
G
S
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
-
E
-
D
Y
D
I
--
K
N
--
G
-
V
G
AQPI
E
I
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N-
D
N
-------
E
A
-
P
-----
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
--
L
F
S
D
T
V
-------
K
E
N
I
--
L
--
L
--
G
R
P
-
T
A
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
-----
D
R
T
T
L
I
V
A
H
R
L
S
T
I
-
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
Q
G
A
-
Y
E
H
L
Y
S
I
Q
--------
97
HHSearch
75.09
32%
-37
- C2 -
-
3QF4
1
Y288_THEMA
B:
[23-588]
--------
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
-
V
F
V
P
--------
R
R
F
--------
D
L---
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
----------
4
PsiBlast_PDB
74.78
32%
-37
- C2 -
-
4Q4J
-
Y288_THEMA
B:
[25-592]
----------
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
V
F
V
P
R
--------
R
F
D
--------
L
----
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
S
Q
Y
G
------
2
PsiBlast_PDB
73.87
32%
-33
- C2 -
-
4Q4A
1
Y288_THEMA
B:
[25-592]
----------
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
V
F
V
P
R
--------
R
F
D
--------
L
----
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
S
Q
Y
G
------
3
PsiBlast_PDB
73.40
32%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[25-592]
----------
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
V
F
V
P
R
--------
R
F
D
--------
L
----
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
S
Q
Y
G
------
96
HHSearch
71.83
32%
-
- C2 -
-
4Q4H
-
Y288_THEMA
B:
[23-588]
--------
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
-
T
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
--------
V
-
V
F
V
P
--------
R
R
F
--------
D
L---
L
P
R
-
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
-
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
-
L
E
E
E
K
D
D
P
D
A
--
V
-
E
L
----
R
E
V
R
--
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
K
-------
K
K
-
P
-----
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
--
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
--
L
F
S
T
T
V
-------
K
E
N
L
--
K
--
Y
--
G
N
P
G
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
-
I
-
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
-----
G
K
T
S
I
I
I
A
H
R
L
N
T
I
-
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
R
G
F
-
Y
Y
E
L
F
T
----------
11
PsiBlast_PDB
71.28
28%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
--------
G
-
F
G
K
T
--------
D
R
S
--------
V
----
L
L
W
-
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
---
E
Q
E
K
D
E
--
G
-
K
R
----
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
-------
R
E
V
P
-----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
--
L
F
N
D
T
V
-------
A
N
N
I
--
A
Y
A
R
--
T
E
E
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
-
Y
A
Q
L
H
K
M
Q
F
G
------
10
PsiBlast_PDB
71.27
28%
-
- C2 -
-
3B5Y
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
--------
G
-
F
G
K
T
--------
D
R
S
--------
V
----
L
L
W
-
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
---
E
Q
E
K
D
E
--
G
-
K
R
----
V
I
D
R
AT
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
-------
R
E
V
P
-----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
--
L
F
N
D
T
V
-------
A
N
N
I
--
A
Y
A
R
--
T
E
E
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
-
Y
A
Q
L
H
K
M
Q
F
G
------
13
PsiBlast_PDB
71.16
28%
-
- C2 -
-
3B5W
-
MSBA_ECOLI
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
V
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
--------
G
-
F
G
K
T
--------
D
R
S
--------
V
----
L
V
W
-
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
V
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
R
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
T
I
L
D
-
S
---
E
Q
E
K
D
E
--
G
-
K
R
----
V
I
E
R
A
T
G
D
V
E
F
R
N
V
T
F
T
Y
--
P
G
-------
R
D
V
P
-----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
E
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
--
L
F
N
D
T
V
-------
A
N
N
I
--
A
YA
R
--
T
E
Q
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
K
A
D
E
I
V
V
V
E
D
G
V
I
V
E
R
G
T
H
N
D
L
L
E
H
R
G
V
-
Y
A
Q
L
H
K
M
Q
F
G
------
12
PsiBlast_PDB
70.00
28%
-18
- C2 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
--------
G
-
F
G
K
T
--------
D
R
S
--------
V
----
L
L
W
-
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
---
E
Q
E
K
D
E
--
G
-
K
R
----
V
I
D
R
AT
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
-------
R
E
V
P
-----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
--
L
F
N
D
T
V
-------
A
N
N
I
--
A
YA
R
--
T
E
E
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
-
Y
A
Q
L
H
K
M
Q
F
G
------
75
Fugue
69.42
27%
-28
- C2 -
-
3B60
2
MSBA_SALTY
A:
[10-581]
-------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
--------
D
-
G
F
G
K
--------
T
D
R
--------
S
----
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
-
S
E
Q
E
K
D
E
G
K
R
--
V
-
I
D
----
R
A
T
---
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
-------
R
E
V
P
-----
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
--
L
F
N
D
T
V
-------
A
N
N
I
--
A
--
Y
AR
T
E
E
-
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
-
I
-
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
-----
N
R
T
S
L
V
I
A
H
R
L
S
T
I
-
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
-
Y
A
Q
L
H
K
M
Q
F
G
------
54
PsiBlast_CBE
43.46
41%
-12
- C2 -
-
2FGJ
2
HLYBP_ECOLX
C:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
51
PsiBlast_CBE
43.20
41%
-14
- C2 -
-
2FGK
2
HLYBP_ECOLX
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
49
PsiBlast_CBE
42.67
41%
-10
- C2 -
-
2FGK
2
HLYBP_ECOLX
C:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
48
PsiBlast_CBE
42.40
41%
-14
- C2 -
-
2FGK
2
D:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
61
PsiBlast_CBE
42.34
41%
-13
- C2 -
-
1XEF
2
HLYBP_ECOLX
A:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
50
PsiBlast_CBE
40.61
41%
-12
- C2 -
-
2FGK
2
HLYBP_ECOLX
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
53
PsiBlast_CBE
40.24
41%
-6
- C2 -
-
2FGJ
2
D:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
-------
D
S
-
P
V----
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
--
L
L
N
R
S
I
-------
I
D
N
I
--
S
--
L
--
A
N
P
G
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
-
I
-
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-----
G
R
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
-------
43
PsiBlast_CBE
37.38
44%
-26
- C2 -
-
1MV5
2
LMRA_LACLA
A:
[6-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
D
F
A
Y
--
D
D
-------
S
E
-
Q
-----
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
--
I
M
A
G
T
I
-------
R
E
N
L
T
Y
G
--
L
--
E
G
D
-
Y
-
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
-
I
-
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
-----
G
R
T
T
L
V
I
A
H
R
L
S
T
I
-
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
H
P
L
-
Y
A
K
Y
V
S
E
Q
--------
73
PsiBlast_CBE
24.62
31%
24
- C2 -
-
4MKI
2
ECFA2_CALS4
B:
[7-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
F
I
Y
--
N
E
-------
G
T
-
P
YATV-
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
P
E
YQ
L
F
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
--
G
--
L
--
S
E
E
-
E
-
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
-----
K
S
P
F
-----
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
-
I
-
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
---
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
-----------------------
74
PsiBlast_CBE
24.10
31%
27
- C2 -
-
4MKI
2
ECFA2_CALS4
A:
[7-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
F
I
Y
--
N
E
-------
G
T
-
P
YATV-
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
KK
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
P
E
YQ
L
F
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
--
G
--
L
--
S
E
E
-
E
-
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
-----
K
S
P
F
-----
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
-
I
-
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
---
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
-----------------------