@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1812: (2018-01-20 )
MPKKILVLHTGGTISMQADASGAVVTSSDNPMNHVSNPLEGIQVHALDFFNLPSPHIKPKHMLVLYQKIKEEADNYDGVVITHGTDTLEETAYFLDTMEVPHMPIVLTGAMRSSNELGSDGVYNYLSALRVASDDRAADKGVLVVMNDEIHAAKYVTKTHTTNVSTFQTPTHGPLGLIMKQEILYFKTAEPRVRFDLDHIQGLVPIISAYAGMTDELIDMLDLEHLDGLIIQAFGAGNIPKETAQKLESLLQKGIPVALVSRCFNGIAEPVYAYQGGGVQLQKAGVFFVKELNAQKARLKLLIALNAGLTGQALKDYMEG
Atome Classification :
(45 SA)
.........10........20.-------.--...-.------.---..30...-.....40..----.......50........60........70--..--.--.--....80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....----...190---.----.----...---...200---.--..---....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MP
K
K
I
L
V
L
HTG
G
T
I
S
M
QADA-S-------
G
--
A
V
V
-T------S---SDNP
M
N
H
-VSNPLE-G
I
----
Q
V
H
A
L
D
F
FNLPSPHIK
P
K
H
M
L
V
L
Y
Q
K
I
K
E
--EA--D--N--YD
G
V
V
I
THGTD
T
L
E
E
T
A
Y
F
L
D
TMEVPHM
P
I
V
L
T
GAMRSSNELGS
D
G
V
Y
N
Y
L
S
A
L
RVASDDRAADK
G
V
L
V
V
MNDEI
H
A
A
K
Y
V
T
K
THTTNVSTFQTPTHG
P
L
G
L
I
M
K
Q
E
I
L
Y
F
----KTAE
P
----
R
----
V
----
R
F
D
---
L
D
H
I
Q
G
---
L
--
V
P
---
I
I
S
A
YAG
M
T
D
E
L
I
D
M
L
D
L
E
H
LDG
L
I
I
Q
AFGAGNI
P
K
E
T
A
Q
K
L
E
S
L
L
QKGI
P
V
A
L
V
S
R
C
F
N
GIAE
P
V
Y
A
YQGG
G
V
Q
L
Q
KA
G
V
F
F
V
KELNAQK
A
R
L
K
L
L
I
A
LNAGL
T
G
Q
A
L
K
D
Y
MEG-
13
PsiBlast_PDB
85.32
32%
-56
- C7 -
-
1HFW
2
ASPG_DICCH
A:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
--------------------------------
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
N
RID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
P
K
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
40
PsiBlast_CBE
85.10
32%
-54
- C7 -
-
1HG1
1
ASPG_DICCH
B:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
G
-------------------------------
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
N
RID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
P
K
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
44
PsiBlast_CBE
84.11
32%
-56
- C7 -
-
1HFW
2
ASPG_DICCH
C:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
G
-------------------------------
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
LL
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
NRID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
PK
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
57
PsiBlast_CBE
83.71
33%
-36
- C7 -
-
5K4H
2
ASPG_WOLSU
C:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
---------------
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
P
R
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
4
PsiBlast_PDB
82.63
35%
-48
- C7 -
-
4ECA
-
ASPG2_ECOLI
A:
[33-310]
------------------------------------------------
E
N
L
V
N
A
-
V
P
Q
L
K
D
-
I
A
----
N
V
K
G
E
Q
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
V
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
49
PsiBlast_CBE
81.82
31%
-53
- C7 -
-
5HW0
2
ASPG_DICCH
B:
[8-325]
----
I
V
I
L
A
T
G
G
T
I
A
G
-------------------------------
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
L
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
K
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
N
RID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
P
K
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
M
E
K
G
V
V
V
I
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
5
PsiBlast_PDB
79.13
37%
-39
- C7 -
-
1IHD
-
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
7
PsiBlast_PDB
78.99
37%
-46
- C- -
-
1JJA
-
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
21
PsiBlast_CBE
78.34
37%
-42
- C7 -
-
3ECA
2
ASPG2_ECOLI
D:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
PK
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
22
PsiBlast_CBE
78.27
37%
-40
- C7 -
-
3ECA
2
ASPG2_ECOLI
C:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
PK
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
3
PsiBlast_PDB
78.24
37%
-38
- C7 -
-
1HO3
1
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
6
PsiBlast_PDB
78.17
37%
-36
- C7 -
-
1JAZ
-
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
60
PsiBlast_CBE
78.03
33%
14
- C7 -
-
5K4G
2
ASPG_WOLSU
C:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
54
PsiBlast_CBE
77.93
33%
11
- C7 -
-
5K4H
2
ASPG_WOLSU
F:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
---YSA----
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T
---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
17
PsiBlast_PDB
77.89
33%
14
- C7 -
-
5K4G
2
ASPG_WOLSU
A:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
P
R
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
1
PsiBlast_PDB
77.88
37%
-40
- C7 -
-
3ECA
2
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
53
PsiBlast_CBE
77.83
33%
17
- C7 -
-
5K4H
2
ASPG_WOLSU
G:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
61
PsiBlast_CBE
77.65
33%
14
- C7 -
-
5K4G
2
ASPG_WOLSU
B:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
59
PsiBlast_CBE
77.32
33%
16
- C7 -
-
5K4G
2
ASPG_WOLSU
D:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
-----------
D
K
L
L
A
A
-
V
P
A
I
N
D
-
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
68
PsiBlast_CBE
77.19
32%
-13
- C7 -
-
2WT4
1
ASPG_HELPJ
A:
[8-316]
----
I
A
L
L
A
T
G
G
T
I
A
G
S
G
--------------------------------
G
V
K
E
-
L
L
K
A
I
P
-
S
L
NKIA
R
I
Q
G
E
Q
V
S
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
--
L
L
--
D
--
D
SR
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
T
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
G
K
T
R
Y
Y
MQPL
R
K
H
T
T
----
E
----
S
----
E
F
S
---
L
S
Q
L
K
T
---
P
--
L
P
K
V
D
I
I
Y
T
H
A
G
M
T
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
Q
M
G
V
V
I
V
R
S
S
R
V
G
S
G
------
G
V
T
S
G
E
I
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
25
PsiBlast_CBE
77.09
37%
-40
- C7 -
-
1HO3
1
ASPG2_ECOLI
B:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
PK
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
102
Fugue
76.98
35%
42
- C7 -
-
3ECA
2
ASPG2_ECOLI
A:
[1-326]
-
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
-
A
-------
T
--
K
S
--
N
Y
T
V
GKV
G
---
V
E
N
L
V
N
A
-
V
P
Q
L
K
D
-
I
A
----
N
V
K
G
E
Q
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
K----
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
KHTS
D
----
T
----
P
F
D
---
V
S
K
L
N
-EL
P
K
--
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
-----
G
A
T
T
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
Y
23
PsiBlast_CBE
76.88
37%
-39
- C7 -
-
3ECA
2
ASPG2_ECOLI
B:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
PK
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
2
PsiBlast_PDB
76.68
37%
-39
- C7 -
-
1NNS
1
ASPG2_ECOLI
A:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
P
K
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
24
PsiBlast_CBE
76.66
37%
-37
- C7 -
-
1NNS
1
ASPG2_ECOLI
B:
[55-310]
----------------------------------------------------------------------------
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
HTSD
T
----
P
F
D
---
V
S
K
L
N
E
---
L
PK
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
-----
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
69
PsiBlast_CBE
76.41
32%
-9
- C7 -
-
2WLT
1
ASPG_HELPJ
A:
[8-316]
----
I
A
L
L
A
T
G
G
T
I
A
G
S
G
-
A
-
S
-------
L
--
G
S
Y
-
K
------
S
---
G
E
L
G
V
K
E
-
L
L
K
A
I
P
-
S
L
NKIA
R
I
Q
G
E
Q
V
S
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
--
L
L
--
D
--
D
SR
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
T
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
G
K
T
R
Y
Y
MQPL
R
K
H
T
T
----
E
----
S
----
E
F
S
---
L
S
Q
L
K
T
---
P
--
L
P
K
V
D
I
I
Y
T
H
A
G
M
T
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
Q
M
G
V
V
I
V
R
S
S
R
V
G
S
G
------
G
V
T
S
G
E
I
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
----------------
45
PsiBlast_CBE
76.30
32%
-1
- C7 -
-
1HFW
2
ASPG_DICCH
B:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
-----------------------------ALG
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
N
RID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
P
K
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
38
PsiBlast_CBE
76.04
32%
9
- C7 -
-
1HG1
1
ASPG_DICCH
D:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
G
S
---------------------------G--
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
LL
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
NRID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
PK
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---
88
HHSearch
74.97
35%
35
- C7 -
-
1HO3
1
ASPG2_ECOLI
B:
[1-324]
-
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
A
T
KS-----
N
--
F
T
V
-
G
------
K
V--
G
V
E
N
L
V
N
A
V
P
-
Q
L
K
D
I
A
----
N
V
K
G
E
Q
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
----
H
TSDT
P
F
D
VS-
K
L
N
E
L
P
---
K
--
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
Q
D
A
E
-----
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
--
80
PsiBlast_CBE
74.78
31%
-22
- C7 -
-
1DJO
2
ASPQ_PSES7
B:
[50-314]
---------------------------------------------------------------------
V
R
G
E
Q
V
M
Q
I
A
S
E
S
I
T
N
D
D
L
L
K
L
G
K
R
V
A
E
--
L
A
--
D
SN
D
--
V
D
G
I
V
I
T
H
G
T
D
T
L
E
E
T
A
Y
F
L
N
L
V
Q
K
T
D
K
P
I
V
V
V
G
S
M
R
P
G
T
A
M
S
A
D
G
M
L
N
L
Y
N
A
V
A
V
A
S
N
K
D
S
R
G
K
G
V
L
V
T
M
N
D
E
I
Q
S
G
R
D
V
S
K
S
I
N
I
K
T
E
A
F
K
S
-
A
W
G
P
L
G
M
V
V
E
G
K
S
Y
W
F
----
R
L
P
A
K
----
R
HTVN
S
----
E
F
D
---
I
K
Q
I
S
S
---
L
PQ
V
D
---
I
A
Y
S
Y
G
N
V
T
D
T
A
Y
K
A
L
A
Q
N
G
A
K
A
L
I
H
A
G
T
G
N
G
S
V
S
S
R
V
V
P
A
L
Q
Q
L
R
K
N
G
T
Q
I
I
R
S
S
H
V
N
Q
G
----
G
F
V
L
R
N
A
E
Q
P
D
D
K
N
D
W
V
V
A
H
D
L
N
P
E
K
A
R
I
L
A
M
V
A
M
----------------
86
HHSearch
74.56
32%
28
- C7 -
-
5K4G
2
ASPG_WOLSU
B:
[3-328]
-
K
P
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
-------
V
KS
S
Y
S
A
G
------
A
V--
T
V
D
K
L
L
A
A
V
P
-
A
I
N
D
L
A
----
T
I
K
G
E
Q
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
--
L
L
AQ
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
S
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
----
T
Q
S
V
R
----
P
----
H
TLAS
E
F
D
IS-
K
I
E
E
L
P
---
R
--
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
S
T
T
Q
E
A
-----
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
R
E
A
I
Q
K
I
F
S
--
81
PsiBlast_CBE
74.41
31%
-18
- C7 -
-
1DJO
2
ASPQ_PSES7
A:
[50-314]
---------------------------------------------------------------------
V
R
G
E
Q
V
M
Q
I
A
S
E
S
I
T
N
D
D
L
L
K
L
G
K
R
V
A
E
--
L
A
--
D
SN
D
--
V
D
G
I
V
I
T
H
G
T
D
T
L
E
E
T
A
Y
F
L
N
L
V
Q
K
T
D
K
P
I
V
V
V
G
S
M
R
P
G
T
A
M
S
A
D
G
M
L
N
L
Y
N
A
V
A
V
A
S
N
K
D
S
R
G
K
G
V
L
V
T
M
N
D
E
I
Q
S
G
R
D
V
S
K
S
I
N
I
K
T
E
A
F
K
S
-
A
W
G
P
L
G
M
V
V
E
G
K
S
Y
W
F
----
R
L
P
A
K
----
R
HTVN
S
----
E
F
D
---
I
K
Q
I
S
S
---
L
P
Q
V
D
---
I
A
Y
S
Y
G
N
V
T
D
T
A
Y
K
A
L
A
Q
N
G
A
K
A
L
I
H
A
G
T
G
N
G
S
V
S
S
R
V
V
P
A
L
Q
Q
L
R
K
N
G
T
Q
I
I
R
S
S
H
V
N
Q
G
----
G
F
V
L
R
N
A
E
Q
P
D
D
K
N
D
W
V
V
A
H
D
L
N
P
E
K
A
R
I
L
A
M
V
A
M
----------------
75
PsiBlast_CBE
74.22
33%
21
- C7 -
-
5K3O
2
ASPG_WOLSU
C:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
78
PsiBlast_CBE
73.93
31%
-21
- C7 -
-
1DJP
2
ASPQ_PSES7
B:
[50-314]
---------------------------------------------------------------------
V
R
G
E
Q
V
M
Q
I
A
S
E
S
I
T
N
D
D
L
L
K
L
G
K
R
V
A
E
--
L
A
--
D
SN
D
--
V
D
G
I
V
I
T
H
G
T
D
T
L
E
E
T
A
Y
F
L
N
L
V
Q
K
T
D
K
P
I
V
V
V
G
S
M
R
P
G
T
A
M
S
A
D
G
M
L
N
L
Y
N
A
V
A
V
A
S
N
K
D
S
R
G
K
G
V
L
V
T
M
N
D
E
I
Q
S
G
R
D
V
S
K
S
I
N
I
K
T
E
A
F
K
S
-
A
W
G
P
L
G
M
V
V
E
G
K
S
Y
W
F
----
R
L
P
A
K
----
R
HTVN
S
----
E
F
D
---
I
K
Q
I
S
S
---
L
PQ
V
D
---
I
A
Y
S
Y
G
N
V
T
D
T
A
Y
K
A
L
A
Q
N
G
A
K
A
L
I
H
A
G
T
G
N
G
S
V
S
S
R
V
V
P
A
L
Q
Q
L
R
K
N
G
T
Q
I
I
R
S
S
H
V
N
Q
G
----
G
F
V
L
R
N
A
E
Q
P
D
D
K
N
D
W
V
V
A
H
D
L
N
P
E
K
A
R
I
L
A
M
V
A
M
----------------
84
HHSearch
73.77
35%
40
- C7 -
-
1NNS
1
ASPG2_ECOLI
A:
[1-324]
-
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
A
T
K------
S
--
N
Y
T
V
G
------
K
V--
G
V
E
N
L
V
N
A
V
P
-
Q
L
K
D
I
A
----
N
V
K
G
E
Q
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
N
T
--
D
C
--
D
--
K
--
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
T
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
G
K
I
D
Y
Q
----
R
T
P
A
R
----
K
----
H
TSDT
P
F
D
VS-
K
L
N
E
L
P
---
K
--
V
G
---
I
V
Y
N
Y
A
N
A
S
D
L
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
K
T
G
T
A
V
V
R
S
S
R
V
P
T
G
A
T
T
Q
D
A
E
-----
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
--
79
PsiBlast_CBE
73.53
31%
-19
- C7 -
-
1DJP
2
ASPQ_PSES7
A:
[50-314]
---------------------------------------------------------------------
V
R
G
E
Q
V
M
Q
I
A
S
E
S
I
T
N
D
D
L
L
K
L
G
K
R
V
A
E
--
L
A
--
D
SN
D
--
V
D
G
I
V
I
T
H
G
T
D
T
L
E
E
T
A
Y
F
L
N
L
V
Q
K
T
D
K
P
I
V
V
V
G
S
M
R
P
G
T
A
M
S
A
D
G
M
L
N
L
Y
N
A
V
A
V
A
S
N
K
D
S
R
G
K
G
V
L
V
T
M
N
D
E
I
Q
S
G
R
D
V
S
K
S
I
N
I
K
T
E
A
F
K
S
-
A
W
G
P
L
G
M
V
V
E
G
K
S
Y
W
F
----
R
L
P
A
K
----
R
HTVN
S
----
E
F
D
---
I
K
Q
I
S
S
---
L
P
Q
V
D
---
I
A
Y
S
Y
G
N
V
T
D
T
A
Y
K
A
L
A
Q
N
G
A
K
A
L
I
H
A
G
T
G
N
G
S
V
S
S
R
V
V
P
A
L
Q
Q
L
R
K
N
G
T
Q
I
I
R
S
S
H
V
N
Q
G
----
G
F
V
L
R
N
A
E
Q
P
D
D
K
N
D
W
V
V
A
H
D
L
N
P
E
K
A
R
I
L
A
M
V
A
M
----------------
71
PsiBlast_CBE
73.46
33%
20
- C7 -
-
5K45
2
ASPG_WOLSU
C:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
77
PsiBlast_CBE
73.21
33%
21
- C7 -
-
5K3O
2
ASPG_WOLSU
A:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKS
S
Y
S
A
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
P
R
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
73
PsiBlast_CBE
73.19
33%
21
- C7 -
-
5K45
2
ASPG_WOLSU
A:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
L
L
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
P
R
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
76
PsiBlast_CBE
73.10
33%
21
- C7 -
-
5K3O
2
ASPG_WOLSU
B:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
72
PsiBlast_CBE
73.04
33%
21
- C7 -
-
5K45
2
ASPG_WOLSU
B:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
74
PsiBlast_CBE
72.85
33%
19
* C7 *
-
5K3O
2
ASPG_WOLSU
D:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
87
HHSearch
72.67
33%
32
- C7 -
-
2WLT
1
ASPG_HELPJ
A:
[5-330]
-
L
P
T
I
A
L
L
A
T
G
G
T
I
A
G
S
G
--A
S
L------
G
--
S
Y
K
-
S
G-----
E
L--
G
V
K
E
L
L
K
A
I
P
-
S
L
N
K
I
A
----
R
I
Q
G
E
Q
V
S
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
Q
E
--
L
L
--
D
DS
R
--
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
T
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
G
K
T
R
Y
Y
----
M
Q
P
L
R
----
K
----
H
TTES
E
F
S
LSQ
L
K
T
P
L
P
---
K
--
V
D
---
I
I
Y
T
H
A
G
M
T
P
D
L
F
Q
A
S
L
N
S
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
Q
M
G
V
V
I
V
R
S
S
R
V
G
S
G
G
V
T
S
G
E
I
------
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
D
K
A
K
I
Q
E
M
F
E
--
70
PsiBlast_CBE
72.42
33%
20
- C7 -
-
5K45
2
ASPG_WOLSU
D:
[5-314]
---
Q
V
T
I
L
A
T
G
G
T
I
A
G
S
G
E
S
-
S
VKSSYSA
G
--
A
V
T
-
V
------
D
---
K
L
L
A
A
V
P
-
A
I
N
D
L
A
-
T
I
----
K
G
E
Q
I
S
--
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
N
E
LL
A
Q
--
K
--
E
--
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
E
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
G
K
V
E
Y
F
T---
Q
S
V
R
P
----
H
----
T
LAS-
E
F
D
---
I
S
K
I
E
E
---
L
PR
V
D
---
I
L
Y
A
H
P
D
D
T
D
V
L
V
N
A
A
L
Q
A
G
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
K
S
G
V
V
V
A
R
S
S
R
V
G
S
G
-----
S
T
T
Q
E
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
----------------
39
PsiBlast_CBE
71.55
32%
27
- C7 -
-
1HG1
2
ASPG_DICCH
C:
[7-324]
----
I
V
I
L
A
T
G
G
T
I
A
G
----------------------------LG-
V
D
T
L
I
N
A
-
V
P
E
V
K
K
-
L
A
----
N
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
N
E
L
L
A
R
--
D
--
D
--
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
R
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
N
R
I
Y
Y
Q
N
RID
K
L
H
T
T
----
R
----
S
----
V
F
D
---
V
R
G
L
T
S
---
L
P
K
V
D
---
I
L
Y
G
Y
Q
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
E
K
G
V
V
V
M
R
S
T
R
T
G
N
G
I
V
P
P
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
---