@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr1957: (2018-01-23 )
MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHYLAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLVYCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITEDADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPAFHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLYIPKV
Atome Classification :
(44 SA)
........--.10........20........30..-......40......-..50........60........70........80........90........100.......110.......120.......130.......140.......150--.--.-......160.......170.......180.......190-.......200.......210.......220.......230.......-240..-......250-.......260-..--.--....270.......280.......290..-.-....300.......310.......320.......330......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTNSVFQG--
R
S
F
L
AEKDF
T
R
A
E
L
E
Y
L
I
G
L
S
A
H
L
K
-
D
L
K
K
RNIQ
H
H
YLAG-K
N
I
A
L
L
F
EKTSTR
T
R
A
A
F
T
T
A
A
I
DLGAHPEYLGANDIQLGKKES
T
E
D
T
A
K
V
L
G
R
M
FDGIEFR
G
F
S
Q
R
M
V
E
E
L
A
E
FSGVPVWNGLTDEW
H
P
T
Q
M
L
A
D
Y
L
T
V
Q
E
NF---G--R-LE
G
L
T
L
V
Y
CGDGRN
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
V
H
I
F
S
P
K
EL-F
P
E
K
E
I
V
E
L
A
E
G
F
A
KESG
A
H
V
L
I
TEDA
D
E
A
VKD
A
D
V
L
Y
T
D
V
W
VSMGE-
E
-
D
K
F
-
A
E
R
V
A
LLKP-YQV
N
M
D
L
V
K
K-AG--N--E
N
L
I
F
L
H
CLPAFHDTHTV
Y
G
K
D
V
A
E
K
FGV-
E
-
E
M
E
V
T
D
E
V
F
R
S
K
Y
A
R
H
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
A
A
T
L
GNLYIPKV
123
HHSearch
95.43
73%
-67
- C7 -
-
2W37
-
OTCC_LACHI
B:
[22-359]
-
R
Q
N
V
F
Q
G
--
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
---
G
--
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
-
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
-
E
E
R
V
K
E
L
T
P
-
Y
Q
V
N
M
E
A
M
K
K
-
T
G
--
T
PD
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
I
-
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
1
PsiBlast_PDB
93.73
72%
-67
- C7 -
-
2W37
-
OTCC_LACHI
A:
[24-359]
---
N
V
F
Q
G
--
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
---
G
--
K
-
L
Q
G
L
T
L
T
F
M
G
D
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
-
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
-
E
E
R
V
K
E
L
T
P
-
Y
Q
V
N
M
E
A
M
K
K
-
T
G
TP
D
--
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
I
-
T
-
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
125
HHSearch
83.33
52%
-106
* C7 *
-
1VLV
-
OTC_THEMA
A:
[14-324]
--
S
V
N
L
K
G
--
R
S
L
L
T
L
L
D
F
S
P
E
E
I
R
Y
L
L
D
I
S
K
Q
V
K
-
M
E
N
R
S
K
L
R
T
E
R
F
K
G
-
M
T
L
A
M
I
F
E
K
R
S
T
R
T
R
L
A
F
E
T
A
F
A
E
E
G
G
H
P
I
F
L
S
P
N
D
I
H
L
G
A
K
E
S
L
E
D
T
A
R
V
L
G
R
M
V
D
A
I
M
F
R
G
Y
K
Q
E
T
V
E
K
L
A
E
Y
S
G
V
P
V
Y
N
G
L
T
D
E
F
H
P
T
Q
A
L
A
D
L
M
T
I
E
E
N
F
---
G
--
R
-
L
K
G
V
K
V
V
F
M
G
D
T
R
N
N
V
A
T
S
L
M
I
A
C
A
K
M
G
M
N
F
V
A
C
G
P
E
E
L
-
K
P
R
S
D
V
F
K
R
C
Q
E
I
V
K
E
T
D
G
S
V
S
F
T
S
N
L
E
E
A
L
A
G
A
D
V
V
Y
T
D
V
W
A
-------------
R
M
A
L
L
K
P
-
Y
Q
V
N
E
R
V
M
E
M
-
T
G
--
K
--
S
E
T
I
F
M
H
C
L
P
A
V
K
-------------------
G
Q
E
V
T
Y
E
V
I
E
G
K
Q
S
R
V
W
D
E
A
E
N
R
K
H
T
I
K
A
V
M
I
A
T
L
--------
12
PsiBlast_PDB
81.80
50%
-106
- C7 -
-
1VLV
-
OTC_THEMA
A:
[17-324]
-----
L
K
G
--
R
S
L
L
T
L
L
D
F
S
P
E
E
I
R
Y
L
L
D
I
S
K
Q
V
K
-
M
E
N
R
S
K
L
R
T
E
R
F
K
G
-
M
T
L
A
M
I
F
E
K
R
S
T
R
T
R
L
A
F
E
T
A
F
A
E
E
G
G
H
P
I
F
L
S
P
N
D
I
H
L
G
A
K
E
S
L
E
D
T
A
R
V
L
G
R
M
V
D
A
I
M
F
R
G
Y
K
Q
E
T
V
E
K
L
A
E
Y
S
G
V
P
V
Y
N
G
L
T
D
E
F
H
P
T
Q
A
L
A
D
L
M
T
I
E
E
N
F
---
G
--
R
-
L
K
G
V
K
V
V
F
M
G
D
T
R
N
N
V
A
T
S
L
M
I
A
C
A
K
M
G
M
N
F
V
A
C
G
P
E
E
L
-
K
P
R
S
D
V
F
K
R
C
Q
E
I
V
K
E
T
D
G
S
V
S
F
T
S
N
L
E
E
A
L
A
G
A
D
V
V
Y
T
D
V
W
A
-------------
R
M
A
L
L
K
P
-
Y
Q
V
N
E
R
V
M
E
M
-
T
G
--
K
--
S
E
T
I
F
M
H
C
L
P
A
-----------------
V
-
K
-
G
Q
E
V
T
Y
E
V
I
E
G
K
Q
S
R
V
W
D
E
A
E
N
R
K
H
T
I
K
A
V
M
I
A
T
L
--------
42
PsiBlast_CBE
80.93
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
B:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
8
PsiBlast_PDB
80.70
54%
-33
- C7 -
-
1DUV
3
OTC1_ECOLI
G:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
33
PsiBlast_CBE
80.58
54%
-33
- C7 -
-
1DUV
2
OTC1_ECOLI
I:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
36
PsiBlast_CBE
80.57
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
H:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
34
PsiBlast_CBE
80.53
54%
-31
- C7 -
-
1DUV
2
OTC1_ECOLI
H:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
130
HHSearch
80.24
44%
-105
- C7 -
-
1A1S
-
OTCA_PYRFU
A:
[2-313]
---
V
S
L
A
G
--
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
G
K
P
H
R
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
---
G
--
T
-
I
K
G
V
K
V
V
Y
V
G
D
G
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
-
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
-
A
E
A
-
E
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
H
-
A
---
K
--
P
D
Y
M
F
M
H
C
L
P
A
H
R
-------------------
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
----
41
PsiBlast_CBE
80.08
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
C:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
9
PsiBlast_PDB
80.07
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
A:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
39
PsiBlast_CBE
79.96
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
E:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
35
PsiBlast_CBE
79.94
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
I:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
37
PsiBlast_CBE
79.90
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
G:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
38
PsiBlast_CBE
79.84
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
F:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
40
PsiBlast_CBE
79.72
54%
-33
- C7 -
-
2OTC
2
OTC1_ECOLI
D:
[1-331]
---
S
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
P--
G
--
K
A
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
--
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
-
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
29
PsiBlast_CBE
79.43
54%
-30
- C7 -
-
4JFR
1
OTC_VIBVU
C:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
16
PsiBlast_PDB
79.15
42%
-103
- C7 -
-
1A1S
-
OTCA_PYRFU
A:
[6-312]
-------
G
--
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
G
K
P
H
R
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
---
G
--
T
-
I
K
G
V
K
V
V
Y
V
G
D
G
-
N
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
-
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
-
A
E
A
-
E
E
R
R
K
I
F
R
P
-
F
Q
V
N
K
D
L
V
K
H
-
A
---
K
--
P
D
Y
M
F
M
H
C
L
P
A
H
R
G
E
-------------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
-----
5
PsiBlast_PDB
79.06
54%
-25
- C7 -
-
4JHX
2
OTC_VIBVU
A:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
124
HHSearch
78.94
54%
-24
- C7 -
-
1DUV
2
OTC1_ECOLI
H:
[2-333]
----
G
F
Y
H
--
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
---
P
GK
A
-
F
N
E
M
T
L
V
Y
A
G
D
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
-
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
-
K
E
K
W
A
E
R
I
A
L
L
R
E
-
Y
Q
V
N
S
K
M
M
Q
L
T
G
---
N
--
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
H
G
-
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
------
4
PsiBlast_PDB
78.83
54%
-23
- C7 -
-
4JFR
1
OTC_VIBVU
A:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
26
PsiBlast_CBE
78.64
54%
-23
- C7 -
-
4JQO
3
OTC_VIBVU
B:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
30
PsiBlast_CBE
78.48
54%
-24
- C7 -
-
4JFR
2
OTC_VIBVU
B:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
25
PsiBlast_CBE
78.33
54%
-23
- C7 -
-
4JQO
3
OTC_VIBVU
C:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
32
PsiBlast_CBE
78.30
54%
-22
- C7 -
-
4H31
10
OTC_VIBVU
B:
[29-357]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
3
PsiBlast_PDB
78.13
54%
-27
- C7 -
-
4H31
12
OTC_VIBVU
A:
[29-357]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
6
PsiBlast_PDB
77.97
54%
-23
- C7 -
-
4JQO
5
OTC_VIBVU
A:
[29-358]
-----
L
R
N
--
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
Q--
G
--
K
A
L
A
D
I
Q
F
A
Y
L
G
D
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
-
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
-
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
--
N
--
P
N
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
M
-
K
-
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
137
HHSearch
77.26
42%
-104
- C7 -
-
4NF2
3
OTC_BACAN
A:
[30-335]
--
V
P
K
L
N
T
--
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
----
Q
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
--
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
E
--
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
---
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
R
-------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
45
PsiBlast_CBE
75.70
40%
-104
- C7 -
-
4NF2
3
OTC_BACAN
C:
[36-335]
----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-----
K
N
K
Q
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
--
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
---
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
47
PsiBlast_CBE
75.07
40%
-104
- C7 -
-
4NF2
3
OTC_BACAN
A:
[36-335]
----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-----
K
N
K
Q
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
--
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
---
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
46
PsiBlast_CBE
74.98
40%
-104
- C7 -
-
4NF2
3
OTC_BACAN
B:
[36-335]
----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-----
K
N
K
Q
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
---
N
--
T
-
F
K
G
I
K
L
A
Y
V
G
D
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
-
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
-
Y
Q
I
N
K
E
L
V
K
H
-
A
---
K
--
Q
T
Y
H
F
L
H
C
L
P
A
H
------------------
R
-
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
19
PsiBlast_PDB
71.18
40%
-24
- C7 -
-
1EP9
1
OTC_HUMAN
A:
[4-316]
-----
L
K
G
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
--
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
--
S
---
D
W
T
F
L
H
C
L
P
R
-------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
Y
S
P
Q
L
18
PsiBlast_PDB
71.16
40%
-21
- C7 -
-
1C9Y
2
OTC_HUMAN
A:
[4-316]
-----
L
K
G
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
--
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
--
S
---
D
W
T
F
L
H
C
L
P
R
-------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
Y
S
P
Q
L
17
PsiBlast_PDB
71.09
40%
-22
- C7 -
-
1OTH
1
OTC_HUMAN
A:
[4-316]
-----
L
K
G
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
--
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
--
S
---
D
W
T
F
L
H
C
L
P
R
-------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
Y
S
P
Q
L
20
PsiBlast_PDB
70.63
40%
-25
- C7 -
-
1FVO
1
OTC_HUMAN
A:
[4-316]
-----
L
K
G
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
--
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
--
S
---
D
W
T
F
L
H
C
L
P
R
-------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
Y
S
P
Q
L
43
PsiBlast_CBE
70.33
40%
-22
- C7 -
-
1FVO
1
OTC_HUMAN
B:
[4-316]
-----
L
K
G
--
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
---
S
--
S
-
L
K
G
L
T
L
S
W
I
G
D
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
-
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
-
Y
Q
V
T
M
K
T
A
K
V
-
A
A
--
S
---
D
W
T
F
L
H
C
L
P
R
-------------------
K
-
P
E
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
T
D
-
Y
S
P
Q
L
70
PsiBlast_CBE
66.55
35%
-28
- C7 -
-
4A8H
4
PTC_ENTFA
A:
[3-305]
----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
--
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
-
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
-
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
-----
A
N
C
K
F
M
H
C
L
P
A
T
R
G
E
-------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
------------
136
HHSearch
66.20
41%
-16
- C7 -
-
2I6U
3
OTC_MYCTU
C:
[2-306]
-------
I
--
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
--
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
---
D
--
S
D
A
I
V
L
H
C
L
P
A
H
R
-------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
------
69
PsiBlast_CBE
65.51
35%
-28
- C7 -
-
4A8H
4
PTC_ENTFA
B:
[3-305]
----------
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
Q
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
--
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
-
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
-
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
-----
A
N
C
K
F
M
H
C
L
P
A
T
R
G
E
-------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
------------
53
PsiBlast_CBE
64.71
38%
-18
- C7 -
-
2I6U
4
OTC_MYCTU
B:
[3-300]
----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
--
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
---
D
--
S
D
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
52
PsiBlast_CBE
63.80
38%
-11
- C7 -
-
2I6U
3
OTC_MYCTU
C:
[3-300]
----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
--
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
---
D
--
S
D
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
54
PsiBlast_CBE
62.60
38%
-15
- C7 -
-
2I6U
3
OTC_MYCTU
A:
[3-300]
----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
----
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
---
G
--
A
-
L
R
G
L
R
L
S
Y
F
G
D
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
-
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
-
F
Q
L
N
S
R
L
L
A
L
-
A
---
D
--
S
D
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
62
PsiBlast_CBE
61.24
35%
19
- C7 -
-
4A8T
2
PTC_ENTFA
A:
[22-327]
-------
S
MK
R
D
Y
V
T
T
E
T
Y
T
K
E
E
M
H
Y
L
V
D
L
S
L
K
I
K
-
E
A
I
K
N
G
Y
Y
P
Q
L
L
K
N
-
K
S
L
G
M
I
F
Q
Q
S
S
T
R
T
R
V
S
F
E
T
A
M
E
Q
L
G
G
H
G
E
Y
L
A
P
G
-
I
Q
L
G
G
H
E
T
I
E
D
T
S
R
V
L
S
R
L
V
D
I
L
M
A
R
V
E
R
H
H
S
I
V
D
L
A
N
C
A
T
I
P
V
I
N
G
M
S
D
Y
N
H
P
T
Q
E
L
G
D
L
C
T
M
V
E
H
L
PEG
K
--
K
-
L
E
D
C
K
V
V
F
V
G
D
A
-
T
Q
V
C
F
S
L
G
L
I
T
T
K
M
G
M
N
F
V
H
F
G
P
E
G
F
Q
L
N
E
E
H
Q
A
K
L
A
K
N
-
C
E
V
S
G
G
S
F
L
V
T
D
D
A
S
-
S
V
E
G
A
D
F
L
Y
T
D
V
W
Y
G
L
Y
E
A
E
-
L
S
E
-
E
E
R
M
K
V
F
Y
P
K
Y
Q
V
N
Q
E
M
M
D
R
-
A
G
-----
A
N
C
K
F
M
H
C
L
P
A
T
R
G
E
-------------------
E
V
T
D
E
V
I
D
G
K
N
S
I
C
F
D
E
A
E
N
R
L
T
S
I
R
G
L
L
------------