@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKY9: (2017-10-30 )
MMAKENTQQKEIKRQPAVELAVFNLNSVTDVADLQMIASQVQLYLQVCGSTTLEQIKSKANITTVANIFALTGSVLDLMLYATDKKTGDAAVQRGALLAANLIGLFSEPNNEAHARMALRPMFGLMAECLYRENGKIKETDIKRLGLHFNAMIAGDLENFLKETQAKLSSLLISATTLGVTILQSMATPATGINAGITTAAGASAEKRDPKLKFTNWAVPLIDLLGKPSQANLTPKIQPNITSRLQQEATQAIAALSQTLQQQANAGQKYTLAWLLQETLKAIQALENKGNASVPVNQTGEYERHTKGDTLEFVSLQADALNAPPCEGADSQSGKSISYSIGAERVQHADFYLPKIGFSFIRQYNSQMDEFDQSMVGARWMMPFSNMIQRTAQGYLFIDSKGRKHQLPASIIFETYEVPYEGIIVQPLKNGDLVLNFGGDWTFQFHQFSVGQPYQLIQQFNEKTQEKIDLSYLIFEKVAYLQCVNFQLEHAKHQLKFAFNEQVKIMAVFLDDNAEPLAHYDYDTQGNLIKAIDQNGHTRTYEYNYFHQLTRYTDRTGRGQNIRYESTDAKAKAIEEWADDGSFHTKLKWHPRLRQVAVYDAYDVPTYYYFDLNGFTYRTRLADGRESWYSRDGKKRITRQIDFEGRETQQEYNDQDQLVKIVQPNGGIIRFEYNEQGNLVEIKDPEGSIWKREYDENRNVSKEINPLGHITQYKYNNDNQLVEVIDAKGGVKKIQYNELGQMISYTDCSGKSSIWEYDEDGVLTAEQTAKNKVVQYFYSTKGRDKGQLQSIIYPDGLKEYFEHDEEGRLLKHIDTKGLVTEYKYNQVGLLEQRIDANRHSVTYQWDKQGRIQKLINQNQAEYLFGYNPYGYLIREQAFDGEEKHYSYNENGRLFKIRQPNTLTEFDYYADGQIASKSFTHLHTGQKQTEQFDYNLNSQLSRASNEVSQIDFYRNALGQLVREHQHYKIPELKPLTAVLHYEYDELGNLIKTIRPDGHTLNHLVYGSGHIYAIGLNNQEVVSFQRDDLHRETTRLLANGLMQTKQYNDVGLLSSQFIQPEQETQDYLQYQAHRKYHYDKNYLLSQVEDSRLGKLNYQYDPIGRLIAAQSLHKTESFNFDPAGNLIDSDSVLSPAQIKNNLIKSYKGKHYQYDVQGNVTEIIQAGKNLKLTWDNQNRLIRSDNNGLVTEYGYDVFGRRLYKKTTNELTLFGWDGDLMIWESFKSAQTNYTKHYIYEPDSFVPLLQTGYKDLIQLIETPDYQEYQTKPYSIYKDPVWNSTTRKKRADLEQITFYHCDQVGIPQTMTNIRGECVWEILQDTWGAVSQIKALNQDNPFEQNNLRFQGQYYDQETELHYNRYRYYEPHSARYVSKDPIGLEGGMNTSSYVSDPNQWIDPKGLNSFNYGEMFGIPASAQSGLAYQGQRNYECYAETGELCKIKVPPLFDYVACSGGGLGIGVGFVKNQWTGEYYISGSKDSLLIPVAKSVAQNKQFSAKDLAGASCVGGNIHNIPSYTKTTMAMGEITNEFVSGASVTVGGGAYGAVANVVVPLVSKSSPVKGTWASELGVGTPGFNVGVSGTVSVDTILDAVKPSKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80......-----..90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.-......240.......250.......260.......270.......280.......290.......300.......310.........320.......330.......340.......350.......360.......370.......380.......390.......400...-....410.......420.......----430.......440.......450.......460....--...470...---....480.......490.......500.......510.......------520.......530...--------...-------.540.......550.......560..-.....570.......580.......590---.......600.......610.......620.-......630....-...640.......650.-......660....-----...----670.......680.--..------------------.-...---------690..---.....700.......------710---.....---...720.------------------------....------------------.-.730-----.-........-740----------------------.....------..---750----......-.---.760.-----.....---------.770-----.......780.......790...---..-----------.---.800-....-...810..---------...-----------.----------.820.......830-........-.-----------840-.......---..850..-...----.----------------.------860--.---........870....-...880.......---890.......-----------.-----------------900---------.........910......--.-920.----......930....-...940...----.--.-..--950....---...960.----------......970.......980.......990.....-..1000...-...1010-....------.------..1020.........---1030-......-----------.1040......-.1050..--------....1060--------------......1070..-----....1080.....-----.1090--------.-........1100----.......--..1110----------------------.------.-..------.....1120......---------------1130---..------.....-1140---..-.......1150......1160-----........1170......1180-----.--...---....1190......1200--------.------.....1210......1220......1230......1240--......1250......1260......1270......1280..-----------------------....1290......1300......1310......1320......1330......1340-----......1350......1360......1370......1380--...-.-....1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510.....-.1520......1530......1540......1550......1560......1570......1580......1590
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMAKEN
T
Q
Q
K
E
I
K
RQPA
V
E
L
A
V
F
NLNSVT
D
V
A
D
L
Q
M
I
A
S
Q
V
Q
L
Y
L
Q
V
CGS
T
T
L
E
Q
I
K
SKANI
T
T
V
A
N
I
F
A
L
T
G
S
V
L
D
L
M
L
Y
ATDKKT-----
G
D
A
A
V
QR
G
A
L
L
A
A
N
L
I
G
LFSEPNN
E
A
H
A
R
M
A
L
R
P
M
F
G
L
M
A
E
C
L
Y
RENGKI
K
E
T
D
I
K
R
L
G
L
H
F
N
A
M
I
A
G
D
L
E
N
F
L
K
E
T
Q
A
K
L
S
S
L
L
I
S
A
T
T
L
G
V
T
I
L
Q
S
MATPATGINAGITTAAGASAEKRDPK
L
K
FTNWA
V
P
L
I
D
LLGKPSQANL-TPKIQ
P
N
I
T
S
R
L
Q
Q
E
A
T
Q
A
I
A
A
L
S
Q
T
L
Q
Q
Q
ANAGQ
K
Y
T
L
A
W
L
L
Q
E
T
L
K
A
I
Q
A
L
ENKGNASVPVNQTGEYERHTKGD
T
--
L
E
F
V
S
L
QADALNAPPCEGADSQSG
K
S
I
S
Y
SI
G
A
E
R
V
Q
HADF
Y
L
P
K
I
G
F
S
F
I
R
Q
Y
N
S
Q
M
D
E
F
D
Q
S
M
VGARWMM
P
F
S
N
M
I
Q
R
TAQ
G
Y
L
F
IDSKGRKH-QL
P
A
S
I
I
F
E
TYEVPYE
G
I
I
V
Q
PLK----NG
D
L
V
L
NFGG
D
W
T
F
Q
F
H
QFSVG
Q
P
Y
Q
L
I
Q
Q
F
N
E
K
T
Q
E
--
K
I
D
L
S
Y
L
I
F
---
E
K
V
A
Y
L
Q
CV
N
F
Q
L
E
HA
K
H
Q
L
K
F
AFNE
Q
V
K
I
M
A
V
F
LDDNAE
P
L
A
H------YDYDTQG
N
L
I
K
A
IDQN--------GH
T
-------
R
T
Y
E
Y
N
Y
F
H
Q
L
T
R
YTDRTGRGQN
I
R
Y-ESTD
A
K
A
K
A
I
E
E
WADDGSFH
T
K
L
K
WHPR---L
R
Q
V
A
V
Y
D
AYDV
P
T
Y
Y
Y
F
DLNG
F
T
Y
R
T
RLAD-G
R
E
S
W
YSRD
G
K
K
R
-
I
T
R
QIDFEGR
E
T
Q
Q
EYN-
D
Q
D
Q
L
V
K
I
VQPNG-----
G
I
I
----
R
F
E
YNEQG
N
L
V
E
I
K--DP------------------E-GS
I
---------
W
K
R
E
Y---DENRNV
S
K
EINPLG
H
------
I
T
----
Q
Y
K
YN---NDN
Q
L
V
E
------------------------
V
IDA------------------K-GG-------
V
-
K
K
I
Q
Y
N
E
L-G
Q
M
----------------------
I
S
YTD------CS---GK-----SSIWEY-D---EDG
V
L
-----
T
A
E
Q
T---------AK
N
K
-----
V
V
Q
Y
F
Y
STKGRDKG
Q
L
Q
SIIY
P
D
---
G
L
-----------
K
---
E
Y
F
E-HDEE-G
R
L
L
K
HID---------TKG-----------
L
----------
V
T
E
Y
K
YNQV
G
L
L
---
E
Q
R
IDANR-H-----------
S
---
V
T
Y
QWDK---Q
G
R
I
Q
K
L
-
I
NQ----N----------------Q------A----
E
---
Y
LFGYNPY
G
Y
L
I
R
EQ-AFDGEEK
H
Y
SYNE---N-
G
R
L
F
K
IRQ-----------P-----------------N-----------TL
T
E
F
D
YYADGQIAS
K
S
F
--
T
-
H
LHT----GQK
Q
T
E
Q
FDYNL
N
-
S
Q
L
S
R
ASNE----
V
--
S
-
Q
I
--
D
F
Y
R
N
A
L
---
G
Q
L
V
R
EH----------QHYKIPELK
P
L
T
A
V
L
H
Y
E
Y
D
E
L
G
N
L
I
K
T
IRPDG
H
-
T
L
N
H
L
V
YGS-
G
H
I
Y
A
I
--GLN
N
------
Q
------
E
V
V
---
S
F
Q
R
D
D
L
H
R
---
E
T
T
--
R
L
L
A
N
G
-----------
L
MQT-KQYNDV-G
L
L
S
S
QF--------IQ
P
E
Q
E
T
Q
--------------
D
Y
L
Q
Y
Q
A
H
R
KYH-----Y
D
K
N
Y
L
L
S
Q
VEDS-----RL-----------G-
K
L
N
Y
QYDP
I
-------
G
R
L
I
A
A
Q
--
S
LH-------------------------K------T-ES------FNFDPAGNLIDSDSV---------------L
S
P
----
A
Q
------
I
K
N
N
L
-
I
------
K
S-YKGK
H
Y
Q
Y
DVQG
N
V
T
E
I
I
Q-------AGK
N
L
K
L
T
WDNQN
R
L
I
RSDN-------N--
G
L
V
---
T
EY
G
Y
D
V
F
G
R
R
L
Y
K
KTTN--------
E
------
L
T
L
F
GWDGD
L
M
I
W
E
S
F
K
S
AQTNY
T
K
H
Y
I
YEPDS
F
V
P
L
L
Q
--
T
G
Y
K
D
L
I
Q
L
IETP
D
Y
Q
E
YQTKPY
S
I
YKDPVWNST
T
R
K
KRA
D
L
-----------------------
E
Q
I
T
F
Y
HCDQVGI
P
Q
T
M
T
N
I
R
G
E
C
V
W
E
I
L
Q
D
T
W
G
A
V
S
Q
I
K
A
LNQDNPFEQN
N
L
R
F
Q
G
Q
-----
Y
YDQETE
L
H
YN
R
Y
R
Y
YEPHSARYVSKDPIGLEGGMNTS----SYV-S-DPNQWIDPKGLNSFNY
G
E
MFGIPASAQSG
L
A
YQGQR
N
Y
E
C
YAETG
E
L
C
K
I
KVPP
L
F
D
Y
V
ACSGG
G
L
G
I
G
V
G
F
V
KNQWT
G
E
Y
Y
ISGSK
D
S
L
L
I
P
V
A
K
S
V
AQNKQFSAKDLAG
A
S
CVGGNIHNIPS
Y
T
K
T
T
M
A
M
G
-
E
I
T
N
E
F
VSGA
S
V
T
VGGG
A
Y
G
A
V
A
N
V
V
V
P
LVSKSSPVKGT
W
A
S
ELGVGTPGFNVGVS
G
T
V
S
V
D
T
I
L
D
AVKPSKK
11
Fugue
45.98
16%
48
- C6 -
-
5M3F
-
RPA1_YEAST
A:
[1-1662]
---------
M
D
I
S
K
P
V
G
S
E
I
T
S
V
D
F
G
I
L
T
A
K
E
I
R
N
L
S
A
K
Q
I
T
------
N
P
T
V
L
D
N
L
G
H
-----------
P
V
S
G
G
L
Y
D
L
A
L
G
A
F
L
R
N
L
CSTCG
L
D
E
K
F
C
P
G
H
Q
G
H
I
E
L
P
V
P
C
Y
N
P
L
F
F
N
Q
L
Y
I
Y
L
R
------
A
S
C
L
F
C
H
H
F
R
L
K
S
V
E
V
H
R
Y
A
C
K
L
R
L
L
Q
Y
G
L
I
D
E
S
Y
K
L
D
E
I
T
L
S
S
T
L
L
N
E
L
K
S
K
R
S
E
Y
V
D
M
A
I
A
K
A
L
S
D
G
R
T
T
E
R
G
S
F
T
A
T
V
N
D
E
R
K
K
L
V
H
E
F
H
K
K
L
L
S
R
G
K
C
D
N
C
G
M
F
S
P
K
F
R
K
D
G
F
T
K
I
F
E
T
A
L
N
-----
E
K
Q
I
T
N
N
R
V
K
G
S
T
Y
I
L
S
T
E
V
K
N
I
L
D
T
V
F
R
K
E
Q
C
V
L
Q
Y
V
F
H
S
R
P
N
L
S
R
K
L
V
K
A
D
S
FF
M
D
V
L
V
V
P
P
T
R
F
R
L
P
S
K
L
G
E
E
V
H
E
N
---
S
Q
N
Q
L
L
S
K
V
L
T
T
S
L
L
I
R
D
L
N
D
D
L
S
K
L
Q
K
D
K
V
S
L
E
D
R
R
V
I
F
S
R
L
M
N
A
F
V
T
I
Q
N
D
V
N
A
F
I
D
S
T
K
A
Q
G
R
T
S
G
K
V
P
I
P
G
V
K
Q
A
L
E
-
K
K
E
G
L
F
R
K
H
M
M
GKRV
N
Y
A
A
R
S
V
I
S
P
D
P
N
I
E
T
N
E
I
G
V
P
P
V
F
A
V
K
L
T
Y
P
E
P
V
T
A
YN
I
A
E
L
R
Q
A
V
I
N
GP
D
K
W
P
G
A
T
Q
I
Q
N
E
D
G
S
L
V
S
L
I
G
M
S
V
E
Q
R
K
A
L
A
N
Q
L
L
T
P
S
S
N
V
S
T
H
T
L
N
K
K
V
Y
R
H
I
K
N
R
D
V
V
L
M
N
R
Q
P
TLHKAS
M
M
G
H
K
V
R
V
L
P
NE
K
T
L
R
L
H
Y
A
N
T
G
A
Y
N
A
D
F
D
G
D
E
M
N
M
H
F
P
Q
N
E
N
A
R
A
E
A
L
N
L
A
N
T
D
S
Q
Y
L
T
P
T
S
G
S
P
V
R
G
L
I
Q
D
H
I
S
A
G
V
W
L
T
S
K
D
S
F
F
T
R
E
Q
Y
Q
Q
Y
I
Y
G
C
I
-
R
P
E
D
G
H
T
T
R
S
K
I
V
-
T
L
P
P
T
I
F
K
P
Y
P
L
W
T
G
K
Q
-
I
I
T
T
V
L
L
N
V
T
P
P
D
M
P
---
G
I
N
----
L
I
S
K
N
K
---
I
K
N
E
Y
--
W
G
------------------
K
-
G
S
L
---------
E
N
E
V
L
---
F
K
D
G
A
L
L
C
G
I
L
D
K
S
Q
------
Y
G
----
A
S
K
Y
G
---
I
V
H
S
L
H
E
------------------------
V
Y
G
P
------------------
E
-
V
A
-------
A
-
K
V
L
S
V
--
L
-
G
R
L
----------------------
F
T
N
Y
I
------
T
A
---
T
A
-----
F
T
C
G
M
D
-
D
---
L
R
--
L
-----
T
A
E
G
N
---------
K
W
R
T
-----
D
I
L
K
T
S
V
D
T
G
R
E
A
A
A
E
V
T
N
L
D
K
D
-----------------------
T
-
P
A
D
D
-
P
E
L
L
K
R
L
Q
---------
E
I
L
-----------
R
----------
D
N
N
K
S
G
I
L
D
A
V
T
---
S
S
K
V
N
A
I
T
-
S
-----------
Q
---
V
V
S
K
C
V
P
---
D
G
T
M
K
K
F
P
C
N
S
----
M
----------------
Q
------
A
----
M
---
A
L
S
G
A
K
G
S
N
V
N
V
S
Q
I
M
C
L
L
G
Q
Q
A
L
----
E
---
G
-
R
R
V
P
V
M
V
S
-----------
G
-----------------
K
-----------
T
L
P
S
F
K
P
Y
E
T
D
A
M
A
G
G
Y
V
--
K
G
R
F
Y
S
----
G
I
K
P
Q
E
Y
Y
F
H
C
M
A
-
G
R
E
G
L
I
D
T
A
----
V
K
T
S
-
R
S
--
G
Y
L
Q
R
C
L
---
T
K
Q
L
E
G
-------------------------
V
H
V
S
Y
D
------
N
S
I
R
D
A
D
G
-
T
L
V
Q
F
M
Y
G
G
-
D
A
I
D
I
T
--
K
E
S
H
------
M
------
T
Q
F
---
E
F
C
L
D
N
Y
Y
A
---
L
L
K
--
K
Y
N
P
S
A
-----------
L
I
E
H
-
L
D
V
E
S
A
-
L
K
Y
S
K
K
T
--------
L
K
Y
R
K
K
H
S
--------------
K
E
P
H
Y
K
Q
S
V
K
Y
D
P
V
L
A
K
Y
N
P
A
K
Y
L
G
S
V
S
E
N
-----
F
Q
-----------
D
-
K
L
E
S
F
L
D
K
N
-------
S
K
L
F
------------------------------------------------------
K
S
S
D
G
V
N
E
K
K
F
---------------
R
A
L
----
M
Q
------
L
K
Y
M
R
-
S
------
L
I
-
N
P
G
E
A
V
G
I
I
A
S
Q
S
V
G
E
P
S
T
-------
Q
M
A
N
V
T
L
G
I
P
R
L
R
E
I
V
M
T
A
S
-------
A
--
A
I
-------------------
K
T
P
--------
Q
------
M
T
L
P
I
W
N
D
V
S
--
D
E
Q
A
D
T
F
C
K
S
I
S
K
V
L
L
S
E
V
I
D
K
V
I
V
T
E
--
R
S
Y
V
I
H
M
R
F
F
D
N
N
E
Y
S
E
----
E
Y
D
V
S
K
E
E
L
Q
N
V
I
S
N
-----------------------------
Q
F
I
H
L
L
E
A
A
I
V
K
E
I
K
K
Q
K
K
V
Q
R
D
R
Q
S
A
I
I
S
H
-
H
R
F
I
T
K
Y
N
F
D
D
E
S
G
K
W
C
E
F
K
L
E
L
A
A
D
TEKLL
M
V
N
I
V
E
E
I
C
R
K
S
I
I
R
Q
I
P
H
I
D
R
C
V
H
P
E
P
E
N
G
K
R
V
L
V
T
E
G
VN
F
Q
A
M
-
W
-
D
Q
E
A
F
I
D
V
D
G
I
T
S
N
D
V
A
A
V
L
K
T
Y
G
--------------------
V
E
A
A
R
N
T
I
V
N
E
I
N
N
V
F
S
R
------------------
Y
A
I
S
V
S
F
R
H
L
D
L
-
I
A
D
M
M
T
R
Q
G
T
Y
L
A
F
N
R
Q
G
M
----------
E
T
S
T
S
S
F
M
K
M
S
Y
E
T
T
C
Q
F
L
T
K
A
V
L
D
----------
N
E
R
E
Q
L
D
S
P
S
A
R
I
V
V
G
K
L
N
N
V
G
T
G
S
F
D
V
L
A
K
V
P
N
----------------
2
PsiBlast_PDB
42.01
21%
65
- C5 -
-
4O9X
-
?
A:
[1532-2191]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
R
G
L
-
I
I
R
N
I
D
F
H
R
T
T
A
N
G
D
-------------
P
D
T
-----
R
I
T
----
R
H
Q
Y
D
I
H
G
H
L
N
Q
S
I
--
D
P
----------------------------------
R
L
Y
----
E
A
K
Q
T
N
N
T
I
K
P
-
N
F
------
L
W
----
Q
Y
D
L
T
---
G
N
P
L
C
T
E
------------------------
S
I
D
A
------------------
G
------------
R
T
V
T
L
N
D
I
E
G
R
P
----------------------
L
L
T
V
T
------
A
T
---
G
V
-----
I
Q
T
R
Q
Y
-
E
---
T
S
S
L
P
GRLL
S
V
A
E
Q
T
---------
P
E
E
K
-----
T
S
R
I
-----------
T
E
R
L
I
W
A
G
---
N
T
-----------
E
---
A
E
K
D
-
H
N
L
A
-
G
Q
C
V
R
H
Y
D
---------
T
A
G
-----------
V
----------
T
R
L
E
S
L
S
L
T
G
T
V
L
S
Q
S
S
Q
L
L
I
D
T
-
Q
-----------
E
---
A
N
W
T
G
D
N
---
E
T
V
W
Q
N
M
-
L
A
D
----
D
----------------
I
------
Y
----
T
---
T
L
S
T
F
D
A
T
G
A
L
L
T
Q
T
-
D
A
K
G
N
I
Q
R
L
A
Y
D
V
---
A
-
G
Q
L
----
N
-----------
G
-----------------
S
-----------
W
L
T
L
K
G
Q
T
E
--
Q
V
I
I
K
S
L
--
T
-
Y
S
A
A
----
G
Q
K
L
R
E
E
H
G
N
D
V
I
-
T
E
Y
S
Y
E
P
E
T
----------------
Q
R
L
I
---
G
I
K
T
R
R
P
----------
S
D
T
K
V
L
Q
------
D
L
R
Y
E
Y
D
P
V
G
N
V
I
-
S
I
R
N
D
A
E
-
A
T
R
F
W
---------------
H
N
------
Q
------
K
V
M
P
E
N
T
Y
T
Y
D
S
L
Y
Q
LI
S
A
T
G
--
R
E
M
A
N
----------------------
I
-
G
Q
Q
S
H
Q
F
--------
P
S
P
A
L
P
S
D
--------------
N
N
T
Y
T
N
Y
T
R
T
Y
T
-----
Y
D
R
G
G
N
L
T
K
I
Q
H
S
-----
S
P
-----------
A
-
T
Q
N
N
Y
T
T
N
I
---------
T
V
S
N
R
--
S
N
R
-------------------------
A
------
V
L
S
T
------
L
T
E
D
P
A
----
Q
V
D
A
L
---------------
F
D
A
----
G
G
------
H
Q
N
T
L
-
I
------
S
----
G
Q
N
L
N
W
N
T
R
G
E
L
Q
Q
V
T
----------------------
L
V
K
R
D
K
GA-----
N
--
D
D
R
---
E
W
Y
R
Y
S
G
D
G
R
R
M
L
K
--
I
N
--------
E
------
Q
------------
Q
A
S
N
N
A
Q
T
---
Q
R
V
T
Y
L
P
N
L
E
L
R
L
T
Q
N
S
T
A
T
T
E
D
L
Q
V
I
T
V
G
E
A
G
R
A
Q
V
R
V
L
H
------
W
E
S
G
-
K
P
E
D
I
D
N
-----------------------
N
Q
L
R
Y
S
Y
D
N
L
I
G
S
S
Q
L
E
L
D
S
E
G
Q
I
I
S
E
E
E
Y
Y
P
Y
G
G
T
A
L
W
A
A
R
N
Q
T
E
A
-
S
Y
K
T
I
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
Y
R
Y
Y
Q
P
W
I
G
R
W
L
S
S
D
P
A
G
T
I
D
G
L
N
L
Y
----
R
M
V
R
N
-
N
P
V
T
L
L
D
P
D
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
40.91
18%
55
- C5 -
-
4O9X
-
?
A:
[1377-2191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
F
S
D
G
F
G
R
L
L
Q
A
A
--
A
R
------------------
H
-
E
A
G
---------
M
A
R
Q
R
---
N
E
D
G
S
L
I
I
N
V
Q
H
T
E
N
------
R
W
A
V
T
G
R
T
E
Y
D
---
N
K
G
Q
P
I
R
------------------------
T
Y
Q
P
YFLNDWRYVS
N
D
S
A
R
Q
EK
E
-
A
Y
-------
A
-
D
T
H
V
Y
D
P
I
-
G
R
E
----------------------
I
K
V
I
T
------
A
K
---
G
W
-----
F
R
R
T
L
F
-
T
---
P
W
F
T
V
-----
N
E
D
E
N
---------
D
T
A
A
-----
E
V
------------------
D
P
K
LYQ
K
T
-----------
P
---
T
V
S
V
-
Y
D
N
R
-
G
L
I
I
R
N
I
D
F
H
R
TTANGD
P
D
T
-----------
R
----------
I
T
R
H
Q
Y
D
I
H
G
H
L
---
N
Q
S
I
D
P
R
L
-
Y
E
A
K
QTNNTIKP
N
---
F
L
W
Q
Y
D
L
---
T
G
N
P
L
C
T
-
E
S
I
----
D
----------------
A
------
G
----
R
---
T
V
T
L
N
D
I
E
G
R
P
L
L
T
V
-
T
A
T
G
V
I
Q
T
R
Q
Y
E
T
SSL
P
-
G
R
L
L
S
V
A
E
-----------
Q
T
PEEK
T
S
R
I
T
E
R
L
I
W
A
G
N
-----------
T
E
A
E
K
D
H
N
L
A
G
Q
C
V
R
H
Y
D
--
T
----------
A
G
V
T
R
L
E
S
L
S
L
T
-
G
T
V
L
S
Q
S
S
Q
L
L
ID
T
--
Q
-
E
A
--
N
W
T
G
D
N
E
---
T
V
W
Q
N
M
L
----------
A
D
--------
D
I
Y
T
T
L
S
T
F
D
A
T
G
A
L
L
T
Q
T
D
A
K
G
N
-
I
Q
R
L
A
Y
D
V
A
-
G
Q
L
N
G
S
--
W
L
T
L
------
K
GQTEQV
I
I
K
---
S
L
T
Y
S
A
A
G
Q
---
K
L
R
--
E
E
H
G
N
D
-----------
V
I
T
E
-
Y
S
Y
E
P
E
T
Q
R
L
I
G
I
K
--------
T
R
R
P
S
D
------------------
T
K
V
L
Q
D
L
R
Y
E
-----
Y
D
P
V
G
N
V
I
S
I
R
N
D
-----
A
E
ATRFWHNQK
V
M
P
-
E
N
T
Y
T
Y
D
S
L
-------
Y
Q
L
I
S
A
T
--
G
R
E
MANIGQQSH
Q
F
P
S
P
ALPSDN
N
T
Y
T
N
Y
------
T
-
R
T
------
Y
T
Y
D
R
G
G
N
L
T
K
I
Q
H
S
---------------
S
P
A
TQN
N
Y
T
T
N
I
T
V
S
N
R
S
N
R
-
A
VLSTLT
E
D
-
P
A
Q
V
D
A
L
F
D
A
G
G
H
Q
N
T
L
I
----------
S
G
Q
N
L
N
W
N
T
R
G
E
L
Q
Q
V
T
L
V
K
R
D
K
GA
N
--
D
D
R
---
E
W
Y
R
Y
S
G
D
G
R
R
M
L
K
I
N
E
Q
QASNNA
Q
T
Q
------
R
V
T
Y
L
P
N
L
E
L
R
L
T
Q
N
S
T
A
T
--
T
E
D
L
Q
V
I
T
V
G
E
A
G
R
A
Q
V
R
--
V
---------------------
L
H
------
W
E
S
G
K
-
P
E
D
I
D
N
-----------------------
N
Q
L
R
Y
S
Y
D
N
L
I
G
S
S
Q
L
E
L
D
S
E
G
Q
I
I
S
E
E
E
Y
Y
P
Y
G
G
T
A
L
W
A
A
R
N
-
Q
T
E
A
S
Y
K
T
I
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
Y
R
Y
Y
Q
P
W
I
G
R
W
L
S
S
D
P
A
G
T
I
D
G
L
N
L
Y
----
R
M
V
-
R
N
N
P
V
T
L
L
D
P
D
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
36.49
16%
48
- C5 -
-
4IGL
2
?
D:
[40-690]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
T
----
Y
H
Q
F
D
F
R
G
F
L
A
Q
S
L
--
D
P
------------------
R
-
L
N
--------------
H
---
K
E
V
T
N
F
S
Y
L
T
D
L
N
G
N
------
I
I
----
Y
T
Q
S
V
---
D
A
G
N
T
L
V
------------------------
L
N
D
T
------------------
E
-
G
R
-------
S
V
I
A
M
T
N
I
S
R
---
N
----------------------
G
K
D
D
L
------
S
L
---
A
V
-----
T
R
T
F
Q
Y
-
E
NAP
L
P
G
R
P
-----
L
S
V
T
E
---------
Q
V
N
G
E
N
A
R
I
T
E
H
F
V
Y
A
----
G
N
T
-------------------------
P
---
Q
E
K
N
-
L
N
L
A
-
G
Q
C
V
S
Y
Y
D
---------
A
A
G
-----------
L
----------
I
Q
T
D
S
V
S
L
T
G
K
P
---
L
S
V
S
R
K
L
L
-
K
-----------
N
LDD
T
N
I
L
A
D
W
---
Q
G
N
D
T
S
A
-
W
N
S
----
L
----------------
L
------
A
T
E
I
Y
T
---
T
V
T
R
T
D
A
A
G
A
V
L
T
T
I
-
D
A
V
G
N
Q
Q
R
V
A
F
D
I
---
A
-
G
Q
L
S
A
S
W
L
-----------
T
-----------------
L
KGGQEQV----
I
I
K
V
L
T
Y
S
A
A
G
Q
K
L
R
E
E
G
--
G
----------
N
G
V
V
T
T
Y
T
Y
E
A
E
T
Q
R
L
I
G
I
K
T
E
----
R
--
P
-
N
-------------
G
H
A
--------------------
A
G
A
K
V
L
Q
D
L
R
Y
E
Y
D
P
V
G
N
V
L
S
I
T
N
D
A
--------------------------------------
P
E
N
---
A
Y
R
Y
D
S
L
Y
Q
---
L
V
S
--
A
S
G
R
E
V
-----------
A
G
A
G
Q
Q
G
S
D
L
P
-
S
P
L
V
P
L
P
--------
S
D
S
S
--------------------
V
Y
T
N
Y
T
R
T
Y
T
-----
Y
D
S
A
G
N
L
M
R
I
R
H
S
-----
A
P
-----------
A
T
N
N
N
Y
T
---------------------------------------------------------
L
N
------
I
T
V
S
E
R
S
N
R
G
V
M
S
S
L
---------------
T
---------------------------
E
N
-
P
A
D
V
D
A
L
F
T
A
S
G
S
Q
K
C
L
Q
----------
Q
G
Q
S
L
I
W
T
P
R
G
E
L
R
T
V
L
L
V
A
R
G
ET-
A
--
D
D
S
---
E
S
Y
R
Y
D
G
S
S
Q
R
I
L
K
I
S
S
Q
--------
Q
TNHSAR
V
Q
R
A
L
Y
L
P
G
L
E
W
R
T
M
T
G
--
A
E
A
E
N
L
Q
V
I
C
I
G
E
A
---
Q
V
R
-----------------------
V
L
------
H
W
E
S
G
K
-
P
D
G
I
I
N
-----------------------
D
Q
I
R
W
S
Y
D
N
L
T
C
S
S
G
L
E
V
D
G
D
G
L
V
I
S
M
E
E
Y
Y
P
Y
G
G
T
A
V
W
A
A
R
S
-
H
I
E
T
A
Y
K
T
V
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
F
R
Y
Y
Q
P
W
A
G
R
W
L
S
A
D
P
A
G
T
V
D
G
L
N
L
Y
----
R
M
V
-
R
N
N
P
L
R
L
T
D
P
D
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
35.89
16%
48
- C5 -
-
4IGL
-
?
B:
[40-690]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
T
----
Y
H
Q
F
D
F
R
G
F
L
A
Q
S
L
--
D
P
------------------
R
-
L
N
--------------
H
---
K
E
V
T
N
F
S
Y
L
T
D
L
N
G
N
------
I
I
----
Y
T
Q
S
V
---
D
A
G
N
T
L
V
------------------------
L
N
D
T
------------------
E
-
G
R
-------
S
V
I
A
M
T
N
I
S
R
--
E
N
----------------------
G
K
D
D
L
------
S
L
---
A
V
-----
T
R
T
F
Q
Y
-
E
NAP
L
P
G
R
P
-----
L
S
V
T
E
---------
Q
V
N
G
E
N
A
R
I
T
E
H
F
V
Y
A
----
G
N
T
-------------------------
P
---
Q
E
K
N
-
L
N
L
A
-
G
Q
C
V
S
Y
Y
D
---------
A
A
G
-----------
L
----------
I
Q
T
D
S
V
S
L
T
G
K
P
---
L
S
V
S
R
K
L
L
-
K
-----------
N
LDD
T
N
I
L
A
D
W
---
Q
G
N
D
T
S
A
-
W
N
S
----
L
----------------
L
------
A
T
E
I
Y
T
---
T
V
T
R
T
D
A
A
G
A
V
L
T
T
I
-
D
A
V
G
N
Q
Q
R
V
A
F
D
I
---
A
-
G
Q
L
S
A
S
W
L
-----------
T
-----------------
L
KGGQEQV----
I
I
K
V
L
T
Y
S
A
A
G
Q
K
L
R
E
E
G
--
G
----------
N
G
V
V
T
T
Y
T
Y
E
A
E
T
Q
R
L
I
G
I
K
T
E
----
R
--
P
-
N
-------------
G
H
A
--------------------
A
G
A
K
V
L
Q
D
L
R
Y
E
Y
D
P
V
G
N
V
L
S
I
T
N
D
A
-------------------------------
V
------
P
E
N
---
A
Y
R
Y
D
S
L
Y
Q
---
L
V
S
--
A
S
G
R
E
V
-----------
A
G
A
G
Q
Q
G
S
D
L
P
-
S
P
L
V
P
L
P
--------
S
D
S
S
--------------------
V
Y
T
N
Y
T
R
T
Y
T
-----
Y
D
S
A
G
N
L
M
R
I
R
H
S
-----
A
P
-----------
A
T
N
N
N
Y
T
---------------------------------------------------------
L
N
------
I
T
V
S
E
R
S
N
R
G
V
M
S
S
L
---------------
T
---------------------------
E
N
-
P
A
D
V
D
A
L
F
T
A
S
G
S
Q
K
C
L
Q
----------
Q
G
Q
S
L
I
W
T
P
R
G
E
L
R
T
V
L
L
VARGET-
A
--
D
D
S
---
E
S
Y
R
Y
D
G
S
S
Q
R
I
L
K
I
S
S
Q
--------
Q
TS
A
R
--
V
Q
R
A
L
Y
L
P
G
L
E
W
R
T
M
T
G
----
A
E
N
L
Q
V
I
C
I
G
E
A
---
Q
V
R
-----------------------
V
L
------
H
W
E
S
G
K
-
P
D
G
I
I
N
-----------------------
D
Q
I
R
W
S
Y
D
N
L
T
C
S
S
G
L
E
V
D
G
D
G
L
V
I
S
M
E
E
Y
Y
P
Y
G
G
T
A
V
W
A
A
R
S
-
H
I
E
T
A
Y
K
T
V
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
F
R
Y
Y
Q
P
W
A
G
R
W
L
S
A
D
P
A
G
T
V
D
G
L
N
L
Y
----
R
M
V
-
R
N
N
P
L
R
L
T
D
P
D
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
Fugue
35.57
17%
45
- C5 -
-
4IGL
-
?
B:
[4-690]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
F
S
---
K
T
-----------
P
---
S
V
T
V
-
F
D
N
R
-
G
L
S
V
R
D
I
A
---------
Y
R
R
-----------
H
----------
P
D
T
P
K
V
T
E
E
C
I
T
---
Y
H
Q
F
D
F
R
G
---------------------
F
L
A
---
Q
S
L
D
P
R
L
-
N
H
K
----
E
----------------
V
------
T
----
N
---
F
S
Y
L
T
D
L
N
G
N
I
I
Y
T
Q
-
S
V
D
A
G
N
T
L
V
L
N
D
T
---
E
-
G
R
S
V
I
A
M
T
NISRENGKDDL
S
-----------------
L
-----------
A
V
T
R
T
F
Q
Y
E
N
A
P
L
P
G
R
P
L
--
S
-
V
T
E
Q
V
N
G
E
N
A
R
I
T
E
H
F
V
Y
A
G
N
-
T
P
Q
E
K
N
L
N
L
----
A
--
G
-
Q
C
--
V
S
Y
Y
D
A
A
---
G
L
I
Q
T
D
S
VSLTGKPL
S
V
S
R
K
L
L
K
N
L
D
D
T
N
I
L
A
D
W
Q
G
N
D
T
S
A
W
N
S
L
L
A
T
E
I
Y
-
T
T
V
T
R
T
D
A
A
-
G
A
V
L
T
T
I
D
A
V
G
N
------
Q
------
Q
R
V
---
A
F
D
I
A
G
Q
L
S
---
A
S
W
--
L
T
L
K
G
G
QEQV-------
I
I
K
V
-
L
T
Y
S
A
A
-
G
Q
K
L
R
E
E
G
GNG
V
V
T
T
Y
T
Y
E
A
E
T
Q
--------------
R
L
I
G
I
K
T
E
R
P
N
G
-----
H
A
A
G
-------
A
K
-----
V
L
-----------
Q
-
D
L
R
Y
E
Y
D
P
V
-------
G
N
V
L
S
I
T
--
N
D
A
-------------------------
V
P
-----
E
-
N
A
------
Y
R
Y
D
S
L
Y
Q
L
V
S
A
S
G
R
E
VAGAGQQGSDLPSP
L
V
P
----
L
P
------
S
D
S
S
V
-
Y
------
T
N
-
Y
T
-
R
T
Y
T
Y
D
S
A
G
N
L
M
R
I
R
H
-------
S
A
P
A
T
N
N
N
Y
T
L
N
I
T
V
S
E
R
S
N
-------
R
--
G
V
M
SSL
T
E
N
P
A
D
V
--
D
A
L
F
T
A
S
G
S
--------
Q
------
K
C
L
Q
--
Q
G
Q
S
L
I
W
T
P
R
G
E
L
R
T
V
L
L
V
A
R
G
E
T
A
D
D
S
E
S
Y
R
Y
--
D
G
S
S
Q
R
I
L
K
I
S
S
Q
Q
T
S
A
R
V
Q
R
A
L
Y
L
-
P
G
L
E
W
R
T
M
T
G
A
E
N
L
Q
V
I
C
I
G
EAQ
V
R
V
L
H
W
ESGKPDGIIN
D
Q
I
R
W
S
Y
D
N
L
T
C
S
S
G
L
E
V
D
G
D
G
L
V
I
S
M
E
E
Y
Y
P
Y
G
G
-
T
A
V
W
A
A
R
S
H
I
E
T
A
Y
K
T
V
R
Y
S
G
K
-----
E
R
D
A
-
T
G
L
Y
Y
Y
G
F
R
Y
Y
Q
P
W
A
G
R
W
L
S
A
D
P
A
G
T
V
D
G
L
N
L
Y
----
R
M
V
-
R
N
N
P
L
R
L
T
D
P
D
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
31.71
31%
-427
- C6 -
-
4CGB
-
EMAL2_HUMAN
A:
[5-48]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
D
R
V
S
A
L
E
Q
R
L
Q
L
Q
E
D
E
L
A
V
--
L
K
A
A
L
A
D
A
L
R
R
L
R
A
C
E
E
Q
G
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
30.78
33%
-162
- C2 -
-
5MZH
-
DAW1_CHLRE
B:
[396-404]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
N
Y
E
G
D
F
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
27.35
15%
62
- C5 -
-
4O9X
-
?
A:
[1376-2020]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
V
F
S
D
G
F
G
R
-
L
L
Q
A
A
A
R
H
E
A
G
M
A
R
Q
R
N
-
E
D
G
S
L
I
I
N
V
Q
H
T
E
-----
N
R
W
A
V
T
G
R
T
E
Y
D
N
K
G
Q
P
I
R
T
Y
--
Q
P
YFLNDWRYVS
N
D
S
A
R
Q
EK
E
-
A
Y
A
---------
D
T
H
V
Y
---
D
P
I
G
R
E
I
K
V
I
T
A
K
G
W
------
F
R
----
R
T
L
F
T
---
P
W
F
T
V
N
E
------------------------
D
E
N
D
------------------
T
-
A
A
-------
E
-
V
-------------------------------------
D
------
P
K
LYQ
K
T
-----
P
T
V
S
V
Y
-
D
---
N
R
G
L
I
-----
I
R
N
I
D
F
H
R
TTANGD
P
D
T
R
-----
I
T
R
H
Q
Y
D
----
I
H
G
H
L
N
Q
S
I
D
P
R
---
L
Y
E
A
K
QTNNTIKP
N
---
F
L
W
Q
-
Y
D
L
T
-
G
N
P
L
C
T
E
S
---------
I
D
A
-----------
G
----------
R
T
V
T
L
N
D
I
E
G
R
P
---
L
L
T
V
T
A
T
G
-
V
-----------
I
---
Q
T
R
Q
Y
E
T
SSL
P
G
R
L
L
S
V
-
A
E
Q
----
T
PEEK
T
S
R
I
T
E
R
L
I
W
A
G
N
------
T
----
E
---
A
E
K
D
H
N
L
A
G
Q
C
V
R
H
Y
-
D
T
A
G
V
T
R
L
E
S
L
S
L
---
T
-
G
T
V
L
S
Q
S
S
-----------
Q
L
L
ID-------------
T
-----------
Q
E
A
N
W
T
G
D
N
E
T
V
W
Q
N
M
L
A
--
D
----------
D
I
Y
T
T
L
S
T
F
D
A
T
-
G
A
L
L
T
Q
T
D
A
----
K
--
G
N
I
Q
--
R
L
A
Y
D
V
A
---
G
Q
L
N
G
S
W
----------
L
T
L
K
--
G
Q
T
E
Q
V
I
I
K
S
L
T
Y
S
A
A
G
Q
K
L
R
E
E
H
G
N
D
V
-
I
T
E
Y
S
Y
E
P
E
T
Q
R
L
I
G
I
--
K
T
R
R
PSDTKV
L
------
Q
D
L
---
R
Y
E
Y
D
P
V
G
N
---
V
I
S
--
I
R
N
D
A
E
ATRFWHNQK
V
M
P
E
N
T
-
Y
T
Y
D
S
L
-
Y
Q
L
I
S
A
T
--------
G
R
E
M
A
N
I
G
QQSH
Q
F
P
S
P
ALPSD
N
N
T
Y
T
N
Y
T
R
T
Y
T
-----
Y
D
R
G
G
N
L
T
K
I
Q
H
S
-----
S
------------
P
-
A
T
Q
N
N
Y
T
T
N
I
T
V
S
NRS
N
R
A
V
L
S
T
LT
E
D
P
-------------------------
A
------
Q
-
V
D
------
A
L
F
D
A
G
G
H
Q
N
T
L
I
S
-------------------------------------------------
G
Q
N
L
N
W
N
T
R
G
E
L
Q
Q
V
T
L
V
K
R
D
K
GA
N
D
D
R
E
W
Y
R
Y
S
G
D
G
R
R
M
L
K
I
N
-------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
27.30
15%
59
- C5 -
-
4IGL
2
?
D:
[41-620]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
Y
H
Q
F
D
F
R
G
F
-
L
A
Q
S
L
D
P
R
L
N
-----
H
K
-
E
V
T
N
F
S
Y
L
T
D
L
N
G
-----
N
I
I
----
Y
T
Q
S
V
D
A
G
N
T
L
V
L
N
--
D
T
------------------
E
-
G
R
S
V--------
I
A
M
T
N
---
I
S
R
--
N
G
K
D
D
L
S
L
A
V
------
T
R
----
T
F
Q
Y
E
NAP
L
P
G
R
P
L
S
------------------------
V
T
E
Q
------------------
V
-
N
G
E
N
A
R
I--
T
-
E
H
F
V
Y
A
G
N
-
T
-----------------------------------------------
P
Q
E
K
N
L
-
N
---
L
A
G
Q
C
-----
V
S
Y
Y
D
---------
A
A
G
L
-----
I
Q
T
D
S
V
S
----
L
T
G
K
P
L
S
V
S
R
K
L
---
L
K
-----------
N
LDD
T
N
I
L
-
A
D
W
Q
-
G
N
D
T
S
A
W
N
---------
S
L
L
-----------
A
T
E
I
Y
------
T
T
V
T
R
T
D
A
A
G
A
V
---
L
T
T
I
D
A
V
G
-
N
-----------
Q
---
Q
R
V
A
F
D
I
---
A
G
Q
L
S
A
S
-
W
L
T
----
L
----------------
K
GGQEQV
I
----
I
---
K
V
L
T
Y
S
A
A
G
Q
K
L
R
E
E
-
G
G
N
G
V
V
T
T
Y
T
Y
E
A
---
E
T
Q
R
L
I
G
I
K
T
-----------
E
-----------------
R
PNGHAAGAKVL
Q
D
L
R
Y
E
Y
D
P
V
G
N
V
L
S
I
T
N
--
D
-
A
----------
P
E
N
A
Y
R
Y
D
S
L
-
Y
Q
L
V
S
A
S
G
R
----
E
--
V
-
A
G
AG
Q
Q
G
S
D
L
P
---
S
P
L
V
P
L
P
----------
S
D
----
S
S
V
Y
T
N
Y
T
R
T
Y
T
Y
D
S
A
G
N
L
M
R
I
R
H
S
A
P
A
T
N
N
N
Y
T
L
N
-----------------------------------
I
T
V
S
E
R
S
N
---
R
G
V
M
S
S
L
T
E
N
P
-----------
A
D
V
D
-
A
L
F
T
A
S
-
G
S
Q
K
C
L
Q
------------------------------------
Q
G
Q
S
L
I
-----
W
T
P
R
G
E
L
R
T
V
L
L
V
A
R
G
ET
A
D
-----------
D
-
S
E
S
Y
R
Y
D
G
S
-------
S
Q
R
I
L
K
I
--
S
S
Q
-------------------------
Q
TNHSAR
V
-
Q
R
------
A
L
Y
L
P
G
L
E
W
R
T
M
T
G
-----------------
A
E
----
A
E
------
N
L
Q
V
I
C
I
------
G
E
A--
Q
V
R
V
L
H
W
E
S
G
K
P
D
G
I
I
--------
N
D
Q
I
R
W
S
Y
D
N
L
T
C
S
S
G
L
E
V
D
-------
G
DG
L
V
I
---
S
M
E
E
Y
Y
P
Y
G
G
T
A
V
W
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
26.64
15%
54
- C5 -
-
4IGL
-
?
B:
[41-620]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
Y
H
Q
F
D
F
R
G
F
-
L
A
Q
S
L
D
P
R
L
N
-----
H
K
-
E
V
T
N
F
S
Y
L
T
D
L
N
G
-----
N
I
I
----
Y
T
Q
S
V
D
A
G
N
T
L
V
L
N
--
D
T
------------------
E
-
G
R
S
V--------
I
A
M
T
N
---
I
S
R
-
E
N
G
K
D
D
L
S
L
A
V
------
T
R
----
T
F
Q
Y
E
NAP
L
P
G
R
P
L
S
------------------------
V
T
E
Q
------------------
V
-
N
G
E
N
A
R
I--
T
-
E
H
F
V
Y
A
G
N
-
T
-----------------------------------------------
P
Q
E
K
N
L
-
N
---
L
A
G
Q
C
-----
V
S
Y
Y
D
---------
A
A
G
L
-----
I
Q
T
D
S
V
S
----
L
T
G
K
P
L
S
V
S
R
K
L
---
L
K
-----------
N
LDD
T
N
I
L
-
A
D
W
Q
-
G
N
D
T
S
A
W
N
---------
S
L
L
-----------
A
T
E
I
Y
------
T
T
V
T
R
T
D
A
A
G
A
V
---
L
T
T
I
D
A
V
G
-
N
-----------
Q
---
Q
R
V
A
F
D
I
---
A
G
Q
L
S
A
S
-
W
L
T
----
L
----------------
K
GGQEQV
I
----
I
---
K
V
L
T
Y
S
A
A
G
Q
K
L
R
E
E
-
G
G
N
G
V
V
T
T
Y
T
Y
E
A
---
E
T
Q
R
L
I
G
I
K
T
-----------
E
-----------------
R
PNGHAAGAKVL
Q
D
L
R
Y
E
Y
D
P
V
G
N
V
L
S
I
T
N
--
D
-
A
---------
V
P
E
N
A
Y
R
Y
D
S
L
-
Y
Q
L
V
S
A
S
G
R
----
E
--
V
-
A
G
AG
Q
Q
G
S
D
L
P
---
S
P
L
V
P
L
P
----------
S
D
----
S
S
V
Y
T
N
Y
T
R
T
Y
T
Y
D
S
A
G
N
L
M
R
I
R
H
S
A
P
A
T
N
N
N
Y
T
L
N
-----------------------------------
I
T
V
S
E
R
S
N
---
R
G
V
M
S
S
L
T
E
N
P
-----------
A
D
V
D
-
A
L
F
T
A
S
-
G
S
Q
K
C
L
Q
------------------------------------
Q
G
Q
S
L
I
-----
W
T
P
R
G
E
L
R
T
V
L
L
V
ARGET
A
D
-----------
D
-
S
E
S
Y
R
Y
D
G
S
-------
S
Q
R
I
L
K
I
--
S
S
Q
-------------------------
Q
TS
A
R
--
V
-
Q
R
------
A
L
Y
L
P
G
L
E
W
R
T
M
T
G
-----------------------
A
E
------
N
L
Q
V
I
C
I
------
G
E
A--
Q
V
R
V
L
H
W
E
S
G
K
P
D
G
I
I
--------
N
D
Q
I
R
W
S
Y
D
N
L
T
C
S
S
G
L
E
V
D
-------
G
DG
L
V
I
---
S
M
E
E
Y
Y
P
Y
G
G
T
A
V
W
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
19.09
0%
-201
* C6 *
-
4R03
-
?
A:
[96-108]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
I
I
P
S
T
N
Y
E
E
I
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
17.89
21%
43
- C6 -
-
5X2G
-
CAS9_CAMJE
A:
[147-469]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
G
A
I
L
K
A
-
I
K
Q
----
N
----------------
E
-----------
E
---
K
L
A
N
Y
Q
S
V
G
E
Y
L
Y
K
E
-
Y
F
Q
------
K
F
K
E
---
N
-
S
K
E
F
T
--------------------------------
N
-----------
V
R
N
K
K
E
S
Y
E
--
R
C
I
A
Q
S
F
L
K
D
-
E
L
K
L
----
I
F
K
K
Q
R
E
F
G
F
S
F
S
-
K
K
F
E
E
---
E
----
V
--
L
-
S
V
--
A
F
Y
K
R
A
L
KDF
S
H
L
V
G
N
C
----------
S
F
F
T
D
E
K
R
A
P
K
N
S
P
L
A
F
M
F
V
A
L
T
R
I
I
-------
N
-
L
L
N
N
L
---------------
K
N
------
T
------
E
G
I
---
L
Y
T
K
D
D
L
N
A
---
L
L
N
--
E
V
L
K
N
G
-----------
T
L
T
Y
-
K
Q
T
K
K
L
-
L
G
L
S
D
D
Y
--------
E
F
K
G
E
K
G
T
--------------
Y
F
I
E
F
K
K
Y
K
E
F
-----------------
I
-------------------------
S
Q
D
D
L
-------
N
E
I
A
K
D
I
--
T
L
I
-------------------------
K
------
D
-
E
I
K
L
K
K
A
L
A
K
Y
D
L
N
Q
N
Q
I
D
S
------------------
L
S
K
----
L
E
------
F
K
D
H
L
-
N
------
I
S
-
F
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
17.58
21%
47
- C6 -
-
5X2H
-
?
A:
[147-470]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
G
A
I
L
K
A
-
I
K
Q
----
N
----------------
E
-----------
E
---
K
L
A
N
Y
Q
S
V
G
E
Y
L
Y
K
E
-
Y
F
Q
------
K
F
K
E
---
N
-
S
K
E
F
T
--------------------------------
N
-----------
V
R
N
K
K
E
S
Y
E
--
R
C
I
A
Q
S
F
L
K
D
-
E
L
K
L
----
I
F
K
K
Q
R
E
F
G
F
S
F
S
-
K
K
F
E
E
---
E
----
V
--
L
-
S
V
--
A
F
Y
K
R
A
L
KDF
S
H
L
V
G
N
C
----------
S
F
F
T
D
E
K
R
A
P
K
N
S
P
L
A
F
M
F
V
A
L
T
R
I
I
-------
N
-
L
L
N
N
L
---------------
K
N
------
T
------
E
G
I
---
L
Y
T
K
D
D
L
N
A
---
L
L
N
--
E
V
L
K
N
G
-----------
T
L
T
Y
-
K
Q
T
K
K
L
-
L
G
L
S
D
D
Y
--------
E
F
K
G
E
K
G
T
--------------
Y
F
I
E
F
K
K
Y
K
E
F
-----------------
I
-------------------------
S
Q
D
D
L
-------
N
E
I
A
K
D
I
--
T
L
I
-------------------------
K
------
D
-
E
I
K
L
K
K
A
L
A
K
Y
D
L
N
Q
N
Q
I
D
S
------------------
L
S
K
----
L
E
------
F
K
D
H
L
-
N
------
I
S
-
F
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
16.73
35%
-106
- C3 -
-
1JLP
-
CM3F_CONPU
A:
[1-24]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
C
L
Y
G
S
C
R
F
G
C
Y
---
N
A
L
C
C
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
15.12
20%
21
- C5 -
-
4GHB
4
?
B:
[42-129]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
Y
L
-
Y
N
S
A
-
G
R
L
T
G
Y
T
G
---------
K
Q
S
F
T
A
GD
E
L
F
E
I
E
N
----------
T
T
T
V
E
Y
K
D
H
Q
-
A
---
V
-
I
T
D
E
A
G
-
T
-----------
V
---
S
T
Y
T
L
N
D
---
K
G
Y
A
T
T
C
-
T
S
Q
D
MAG
N
----------------
T
------
R
----
T
---
Y
T
F
S
Y
L
I
N
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
Fugue
14.86
13%
57
- C5 -
-
4GHB
10
?
A:
[16-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
T
T
P
-
F
S
K
I
E
L
K
E
V
I
E
S
D
A
Q
P
V
T
A
T
H
----
T
Y
L
Y
N
S
A
G
R
L
T
G
Y
T
--
G
K
------------------
Q
-
S
F
T
A
GDEL
F
E
I
E
N
T
T
T
V
---
E
Y
K
D
H
Q
A
V
I
T
D
E
A
G
T
------
V
S
----
T
Y
T
L
N
---
D
K
G
Y
A
T
T
------------------------
C
T
S
Q
------------------
D
M
A
G
N
T
R
T
Y
T
F
S
-
Y
L
I
N
T
E
D
K
-
Y
Y
L
----------------------
E
N
I
T
E
------
K
L
---
D
D
GKEY
S
F
I
T
I
D
Y
-
S
---
N
F
R
A
L
-----
R
I
Q
Q
K
---------
V
D
T
F
-----
E
H
N
S
T
A
T
T
P
---
S
G
N
E
I
A
N
I
S
E
I
---
P
S
-----------
L
---
F
I
T
D
M
Y
P
L
S
M
H
A
V
A
I
Y
G
K
---------
I
L
G
-----------
E
----------
P
A
N
Y
L
I
T
Q
L
I
P
D
---
S
E
--
S
E
E
T
-
T
-----------
T
---
Y
T
Y
T
L
D
N
---
R
G
I
V
T
S
C
-
H
A
V
----
V
----------------
R
------
H
----
I
R
NG
Y
E
Q
D
Y
T
R
T
V
N
Y
T
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
14.35
12%
65
- C5 -
-
4IGL
1
?
A:
[1134-1485]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
G
Y
S
E
F
G
D
Y
S
Q
F
W
R
P
L
S
Q
R
S
T
L
L
T
G
K
T
T
L
K
W
D
K
H
Y
C
V
V
I
E
T
Q
D
A
A
Q
L
V
T
Q
A
R
Y
D
Y
R
F
L
T
P
Y
S
L
T
D
A
N
D
-----
N
Q
H
----
Y
V
V
L
N
P
F
G
E
V
I
A
S
R
F
W
G
T
------------------
E
A
G
K
D
---------
A
G
Y
S
T
PQA
K
P
F
V
V
P
A
T
I
E
A
A
L
A
L
SPGIPV
A
H
----
C
A
I
F
E
---
P
E
S
W
M
Q
K
L
T
Q
H
D
V
S
E
R
M
ADNG
T
L
W
N
A
L
L
Q
A
R
F
V
T
E
------------------
D
-
G
Y
-------
V
-
C
A
L
G
R
R
R
W
-
M
A
R
H
G
L
S
V
L
M
L
T
L
L
A
E
I
P
R
T
P
P
H
S
L
T
I
T
T
D
RYDSDD
Q
Q
---
Q
L
-----
R
Q
R
I
L
F
S
D
---
G
F
G
R
L
-----
L
Q
S
A
Q
---------
R
V
E
A
-----
G
------------------------------------------
E
S
W
Q
-
R
S
E
D
-
S
S
L
V
V
N
V
S
---------
G
T
P
-----------
A
L
V
V
T
DN
R
W
A
V
S
G
R
T
E
Y
D
G
K
G
Q
G
---
I
R
V
Y
Q
P
Y
F
L
D
-----------
D
---
W
R
Y
L
S
D
D
---
S
A
R
-------
T
----
D
----------------
L
------
F
----
A
---
D
T
H
I
Y
D
P
L
G
R
E
Y
Q
V
I
-
T
A
K
G
Y
R
R
E
R
Q
Y
T
P
---
W
----------------------------------------------------
F
V
V
N
Q
D
E
N
D
T
A
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
14.14
32%
-7
- C7 -
-
4IGL
1
?
D:
[619-690]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
R
S
H
I
E
T
A
Y
K
-------
T
V
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
F
R
Y
Y
Q
P
W
A
G
R
W
L
S
A
D
P
A
G
T
V
D
G
L
N
L
Y
----
R
M
V
R
N
-
N
P
L
R
L
T
D
P
D
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
13.68
32%
-9
- C7 -
-
4IGL
-
?
B:
[619-690]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
R
S
H
I
E
T
A
Y
K
-------
T
V
R
Y
S
G
K
-----
E
R
D
-
A
T
G
L
Y
Y
Y
G
F
R
Y
Y
Q
P
W
A
G
R
W
L
S
A
D
P
A
G
T
V
D
G
L
N
L
Y
----
R
M
V
R
N
-
N
P
L
R
L
T
D
P
D
G
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------