@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VL94: (2017-11-01 )
MENIMAYITLRDVQLAFGGPALLDGANFNLERGERVCLIGRNGEGKSTLLKLIEGSLLPDSGEVSVQNGLTVSMLAQDVPMSSGKVADNVAEGAGEAAAVLKAYHEASDACVLGDMEACDRMGSLQHKLDQLDGWALENKVNTILGKMELDPNADLADLSGGRKRRVLLARALLTQPDVLLLDEPTNHLDVESIEWLEKFLLDQNNLTLLFISHDRSFVDRLATRIVELDRGILRSYEGNYSRYLDLKAQQLEAEEKQNALFEKKLAEEEAWIRQGIKARRTRNEGRVRALKALREESKARRFQQGKVNMGVQEAQRSGKLVFDIEHLSVSYDGQTLIRDFSAIVMRGDRIGLVGDNGVGKTTLIKAILGEVQHEGVVKTGTQLEIAYFDQLRNQLDLEKSVSENVSEGSDFVDVNGQRRHILSYLQDFLFSPERARTPVKALSGGERNRVLLAKLLLKPSNLIVMDEPTNDLDMVTLELLEEMLSEYKGTLLLISHDRAFMDNVVTSTWVFDGKGGIAEYIGGYQDYLIQRPNERVVDQKGDVKKAQAKAEAEKNAAQTNVKKVKLSYKDQRELEQLPAEIEKLENEQAELSDKLADGSWFVTDADAATKASQRLAEIEELLLEKLERWDELEQKSKGN
Atome Classification :
(24 SA)
.........10....--.--.-..---20........30........40........50..-------......60...------....-.-----------70........80..-------.-.-.....90........100.......110...---...-.120.......130----.......140.......--150.---...--....160.......170.......180.......190........-.200-..-.--.---....210.......220.......230.......240.......250.------...-...260..-----------------------------------..----.--------.-------------------------------------------------.270.......------280------------------------------------------------------------..-------....---------------------..----------290..-.....300...-------------------------------....----------------------------------------310.-..---------.....320.......330.--.---..--...340.......350.......360.......370...-.-....380.-----------.....-----.390...-.----------..---------.400---.-----------------------------------------------------..------------------......----------------------------------------------410---------.....--------------.--------------------------...420---.........430----------..-.....440.......450.......460.......470.......480......----.--490.......500.......510.......-520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
N
I
M
A
Y
I
T
L
R
D
V
Q
L
--A--F-GG---PALLDGANFNLERG
E
R
V
C
L
I
GRNGE
G
K
S
T
L
L
K
L
I
-------EGSLLPDSG
E
V
------
S
VQN-
G
-----------
L
T
V
S
M
L
A
QDVP-MS-------S-G-K
V
A
D
N
V
A
EGA
G
E
A
A
A
V
L
K
A
Y
H
EASD
A
C
VLG
D
---
M
E
A
-
C
D
R
M
G
S
L
Q
H
K
L
D
Q
L----DG
W
A
L
E
N
K
V
N
T
I
L
GKME--L-DP---NAD--LADLSGGR
K
R
R
V
L
L
A
R
A
LLTQP
D
V
L
L
L
DEPTNHLD--
V
E
S
I
E
W
L
E
-
K
F
L--LD-Q--N---
N
L
T
L
L
F
ISH
D
R
S
F
V
D
R
L
A
T
R
I
V
E
L
D
R
G
I
L
R
SYEGNYS
R
Y
L
D
L
K
A
Q
Q
L
E
------
A
E
E
-
K
Q
N
A
L
F
E
K
-----------------------------------
K
L
----
A
--------
E
-------------------------------------------------
E
E
A
W
I
R
Q
G
I
K
A
------RR-------------------------------------------------------------TR-------NE
G
R
---------------------
V
R
----------
A
L
K
A
L
-
R
E
E
S
K
A
R
R
F
QQ-------------------------------GKVN----------------------------------------M-
G
V
-
Q
E
---------
A
Q
RSG
K
L
V
F
D
I
E
H
L
S
VSYD--
G
---
Q
T
--
L
I
R
D
F
S
A
I
V
MRG
D
R
I
G
L
VGDNGV
G
K
T
T
L
I
K
A
I
L
G
E
-
V
Q
H-E-GVVKTG
T
Q
-----------
L
E
I
A
Y
-----
F
D
Q
L
R
N
Q
-L----------
D
L
---------
E
K
-----
S
-----------------------------------------------------
V
S
------------------ENVSEG----------------------------------------------S-----------
D
F
V
DV--------------N--------------------------G
Q
R
R
-----
H
I
L
S
Y
L
Q
D
F
LFS----------
P
E
-RARTP
V
K
ALSGGER
N
R
V
L
L
A
K
L
LLKPS
N
L
I
V
MDEPTND
L
D
M
V
T
L
E
L
L
E
E
M
L
S
EY----K--
G
T
L
L
L
I
SH
D
R
A
F
M
D
N
VVT
S
T
W
V
FDGKG
G
I
A
-
E
Y
IG
G
Y
Q
D
Y
L
I
QRPN
E
R
VVDQKG
D
V
K
K
A
Q
A
K
A
E
A
EKNAAQTN
V
K
K
V
K
L
SY
K
D
Q
R
E
L
E
Q
L
P
A
E
I
E
K
L
E
N
E
Q
A
E
L
S
DKLADG
S
W
F
V
TDADA
A
T
K
A
S
Q
R
L
A
E
I
E
E
L
L
L
E
K
L
E
R
W
D
E
L
E
Q
KSKGN
1
PsiBlast_PDB
78.57
35%
10
- C3 -
-
3J5S
-
ETTA_ECOLI
D:
[21-530]
-----------------------------
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
-------
A
G
I
D
K
D
I
E
G
E
A
------
R
P
Q
P
-
D
-----------
I
K
I
G
Y
L
P
Q
E
P
Q
-
L
N
-------
P
E
H
-
T
V
R
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
--
A
L
Y
A
D
---
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
IQAH
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
--
L
P
D
W
---
D
A
K
--
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
--
A
E
S
V
A
W
L
E
-
R
F
L
--
H
D
-
F
--
E
---
G
-
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
------
Q
E
A
-
S
Q
E
A
A
R
R
K
-----------------------------------
S
I
----
E
--------
K
-------------------------------------------------
E
L
E
W
V
R
Q
G
T
K
G
------
R
Q
-------------------------------------------------------------
S
K
-------
G
K
A
R
---------------------
L
A
----------
R
F
E
E
L
-
N
S
T
E
Y
Q
K
R
N
E
T
-------------------------------
N
E
------------------------------------------
L
-
F
I
-
P
P
---------
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
---
R
L
--
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
-
E
Q
P
-
D
S
G
T
I
T
L
G
E
T
-----------
V
K
L
A
S
-----
V
D
Q
F
R
D
S
-
M
----------
D
N
---------
S
K
-----
T
-----------------------------------------------------
V
W
------------------
E
E
V
S
G
G
----------------------------------------------
L
-----------
D
I
M
K
I
--------------
G
--------------------------
N
T
E
M
-----
P
S
R
A
Y
V
G
R
F
N
F
K
----------
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
--
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
E
-
F
F
E
G
N
F
T
E
Y
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.41
35%
33
- C2 -
-
4FIN
6
ETTA_ECOLI
A:
[21-530]
-----------------------------
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
-------
A
G
I
D
K
D
I
E
G
E
A
------
R
P
Q
P
-
D
-----------
I
K
I
G
Y
L
P
Q
E
P
Q
-
L
N
-------
P
E
H
-
T
V
R
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
--
A
L
Y
A
D
---
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
IQ------
L
N
V
Q
L
E
R
A
A
D
A
L
R
--
L
P
D
W
---
D
A
K
--
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
--
A
E
S
V
A
W
L
E
-
R
F
L
--
H
D
-
F
--
E
---
G
-
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
------
Q
E
A
-
S
Q
E
A
A
R
R
K
-----------------------------------
S
I
----
E
--------
K
-------------------------------------------------
E
L
E
W
V
R
Q
G
T
K
-----------------------------------------------------------------------
K
-------
G
K
A
R
---------------------
L
A
----------
R
F
E
E
L
-
N
S
T
E
Y
Q
K
R
N
E
T
-------------------------------
N
E
------------------------------------------
L
-
F
I
-
P
P
---------
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
---
R
L
--
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
-
E
Q
P
-
D
S
G
T
I
T
L
G
E
T
-----------
V
K
L
A
S
-----
V
D
Q
F
R
D
S
-
M
----------
D
N
---------
S
K
-----
T
-----------------------------------------------------
V
W
------------------
E
E
V
S
G
G
----------------------------------------------
L
-----------
D
I
M
K
I
--------------
G
--------------------------
N
T
E
M
-----
P
S
R
A
Y
V
G
R
F
N
F
K
----------
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
--
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
E
-
F
F
E
G
N
F
T
E
Y
----------------------------------------------------------------------------------------------------------------
58
HHSearch
73.14
35%
54
- C3 -
-
3J5S
-
ETTA_ECOLI
D:
[8-534]
---------
M
H
R
V
G
K
--
V
--
V
P
P
K
---
R
H
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
-------
A
G
I
D
K
D
I
E
G
E
A
------
R
P
Q
P
-
D
-----------
I
K
I
G
Y
L
P
Q
E
P
Q
-
L
N
-------
P
-
E
H
T
V
R
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
P
D
ADF
D
K
L
-
A
A
E
Q
G
R
L
E
E
I
I
Q
A
H
----
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
--
L
-
P
D
W--
D
A
K
--
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
--
A
E
S
V
A
W
L
E
-
R
F
L
--
H
D
-
F
------
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
------
Q
E
A
-
S
Q
E
A
A
R
R
K
-----------------------------------
S
I
----
E
--------
K
-------------------------------------------------
E
L
E
W
V
R
Q
G
T
K
G
------
R
Q
-------------------------------------------------------------
S
K
-------
G
K
A
R
---------------------
L
A
----------
R
F
E
E
L
-
N
S
T
E
Y
Q
-
K
-
R
N
-------------------------------
E
T
N
E
----------------------------------------
L
-
F
I
-
P
P
---------
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
---
R
L
--
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
-
E
Q
P
D
S
-
G
T
I
T
L
G
E
T
-----------
V
K
L
A
S
-----
V
D
Q
F
R
D
S
-
M
----------
D
N
---------
S
K
-----
T
-----------------------------------------------------
V
W
------------------
E
E
V
S
G
G
----------------------------------------------
L
-----------
D
I
M
K
I
--------------
G
--------------------------
N
T
E
M
-----
P
S
R
A
Y
V
G
R
F
N
F
K
----------
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
--
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
-
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
------------------------------------------------------------------------------------------------------------
65
HHSearch
69.94
28%
29
- C2 -
-
2IW3
1
EF3A_YEAST
A:
[435-978]
--------
D
L
C
N
C
E
F
--
S
L
A
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
N
G
Q
V
D
--
G
F
P
------
T
Q
E
E
-
C
-----------
R
T
V
Y
V
E
H
D
I
D
G
-
T
H
-------
S
-
D
T
S
V
L
D
F
V
F
E
S
G
V
G
------------------------------------------------
T
K
E
A
I
K
D
K
L
I
E
F
G
--
F
-
T
D
E
M
I
A
M
P
--
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
L
--
N
T
-
C
------
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
-------------------------------------------------------------------------------------------------------------------------
Y
----------------------------------------------------------------------------------------------------------------------------
E
E
L
-
S
N
T
D
L
E
-
F
-
K
F
-------------------------------
P
E
P
G
----------------------------------------
Y
-
L
--
E
G
---------
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
--
G
TS-
K
P
--
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
-
L
L
P
T
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
-----
I
K
Q
H
A
F
A
H
I
ESHLDKT
P
S
E
Y
I
---------
Q
W
R
F
Q
TG
E
DRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
------------------
E
N
I
G
M
K
----------------------------------------------
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
R
--------------
G
ELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRP
L
T
R
K
-----
E
I
E
E
H
C
S
M
L
G
L
D
----------
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
--
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
-
G
R
M
T
-
P
------------------------------------------------------------------------------------------------------------------------
73
HHSearch
66.62
28%
31
- C3 -
-
2IX8
-
A:
[1429-1972]
--------
D
L
C
N
C
E
F
S
L
A
--
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
N
G
Q
V
D
--
G
F
P
------
T
Q
E
E
-
C
-----------
R
T
V
Y
V
E
H
D
I
D
G
-
T
H
-------
S
-
D
T
S
V
L
D
F
V
F
E
S
G
V
G
------------------------------------------------
T
K
E
A
I
K
D
K
L
I
E
F
G
--
F
-
T
D
E
M
I
A
M
P
--
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
L
--
N
T
-
C
------
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
----------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------
E
E
L
-
S
N
T
D
L
E
-
F
-
K
F
-------------------------------
P
E
P
G
----------------------------------------
Y
-
L
--
E
G
---------
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
GT
S
---
K
P
--
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
-
L
L
P
T
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
-----
I
K
Q
H
A
F
A
H
I
ESHLDK----
T
P
S
E
Y
I
Q
W
R
F
Q
T
G
-----------------------------------------------------------
D
R
ETMDRANRQINENDAEAM
N
K
I
F
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGMKSE
R
W
V
P
M
M
SVD
N
-----------
A
W
I
P
R
GELVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFRP--------------
L
T
R
K
-----
E
I
E
E
H
C
S
M
L
G
L
D
----------
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
--
G
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
D
-
G
R
M
T
-
P
------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.36
27%
-106
- C2 -
-
2IW3
1
EF3A_YEAST
A:
[440-761]
-----------
E
F
S
L
--
A
--
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
------
N
G
Q
V
---------
D
-
G
-----------
F
P
T
Q
E
E
C
R
T
V
----------------
Y
V
E
H
D
I
D
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----
V
G
T
---
K
E
A
-------
I
K
D
K
L
I
E
F
-----
G
F
T
D
E
M
I
A
M
P
I
--------------------
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
---
L
N
-
T
--
C
---
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
------
Y
E
E
-
L
S
N
T
D
L
E
F
-----------------------------------
K
F
----
P
--------
E
-------------------------------------------------
P
G
--
Y
L
E
G
V
K
T
------
K
---------------------------------------------------------------------------------------------------------------------------
Q
K
-------------------------------
A
I
V
K
----------------------------------------
V
-
T
N
-
M
E
---------
F
Q
Y
P
G
T
---------------
S
---
K
P
--
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
-
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
-
L
----------
D
-----------
K
-----
T
-----------------------------------------------------
P
S
------------------
E
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.69
27%
-96
- C2 -
-
2IX8
-
A:
[1434-1756]
-----------
E
F
S
L
--
A
--
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
------
N
G
Q
V
---------
D
-
G
-----------
F
P
T
Q
E
E
C
R
T
V
----------------
Y
V
E
H
D
I
D
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----
V
G
T
---
K
E
A
-------
I
K
D
K
L
I
E
F
-----
G
F
T
D
E
M
I
A
M
P
I
--------------------
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
---
L
N
-
T
--
C
---
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
------
Y
E
E
-
L
S
N
T
D
L
E
F
-----------------------------------
K
F
----
P
-----------------------------------------------------------
E
P
G
Y
L
E
G
V
K
T
------
K
---------------------------------------------------------------------------------------------------------------------------
Q
K
-------------------------------
A
I
V
K
----------------------------------------
V
-
T
N
-
M
E
---------
F
Q
Y
P
G
T
---------------
S
---
K
P
--
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
-
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
IKQ
H
A
F
A
H
I
E
S
H
-
L
----------
D
-----------
K
-----
T
-----------------------------------------------------
P
S
------------------
E
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
60.87
22%
36
- C2 -
-
5KO2
-
MDR1A_MOUSE
A:
[386-1223]
-----
G
N
L
E
F
K
N
I
H
F
--
S
--
Y
-
P
S
RKE
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
-------
Q
R
L
Y
D
P
L
D
G
M
V
------
S
I
D
G
-
Q
DIRTIN
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
-
L
F
-------
A
-
T
-
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
--
M
D
E
I
E
K
A
V
K
E
------------------------------------
A
N
A
Y
D
F
I
M
K
L
P
HQ
F
-
D
T
LV-
G
E
R
--
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
--
T
E
S
E
A
V
V
Q
-
A
A
L
--
D
K
-
A
R
-
E
---
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
-
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
V
M
T
Q
T---D
V
P
P
A
S
F
W
R
I
L
K
L
N
STE
W
P
Y
F
V
V
G
I
F
C
A
I
I
N
G
G
L
Q
P
A
F
S
V
I
F
S
K
V
V
G
V
F
T
N
GGPPET
Q
R
Q
N
S
N
L
F
S
L
L
F
L
I
L
G
I
I
S
F
I
T
F
F
L
Q
G
F
T
F
G
K
A
G
E
I
L
T
K
R
L
R
Y
M
V
F
K
S
M
L
R
Q
D
V
S
W
F
D
D
P
K
N
T
T
G
A
L
T
T
R
L
A
NDAAQ
V
K
G
A
T
G
S
R
L
A
V
I
F
Q
N
I
A
N
L
G
T
G
I
I
I
S
L
I
Y
G
W
Q
L
T
L
L
L
L
A
I
V
P
I
I
A
I
A
G
V
V
E
M
K
M
L
S
G
Q
A
L
K
D
K
K
E
L
E
G
S
G
K
I
A
T
E
A
I
E
N
F
R
T
-------
V
V
S
L
TR
E
Q
K
F
E
T
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
H
V
F
G
I
T
F
S
F
T
Q
A
M
M
Y
F
S
Y
A
A
C
F
R
F
G
A
Y
L
V
T
Q
Q
L
M
T
F
E
N
V
L
L
V
F
S
A
I
V
F
G
A
M
A
V
G
Q
V
S
S
F
APD
Y
A
K
A
T
V
S
A
S
H
I
I
R
I
I
E
K
T
P
E
IDSYSTQGL
K
P
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
--
T
RPS
I
P
--
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
-
Y
D
P
M
A
-
G
S
V
F
L
D
G
K
EIKQLN
V
Q
W
L
R
A
Q
L
G
I
-----
V
S
Q
E
P
I
L
-------------
F
---------
D
C
-----
S
-----------------------------------------------------
I
A
------------------
E
N
I
A
Y
G
----------------------------------------------
D
-----------
N
S
R
V
V
--------------
S
----------------------------
Y
E
-----
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
I
D
S
LPDKY
N
T
-
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
----
R
E
G
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
-
G
K
V
K
-
E
-
H
G
T
H
Q
Q
L
L
---------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
59.85
25%
-33
- C2 -
-
2IWH
1
EF3A_YEAST
A:
[440-761]
-----------
E
F
S
L
--
A
--
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
------
N
G
Q
V
DGF---
P
T
Q
E
-
E
-----------
C
R
T
V
Y
V
E
H
D
I
----------------------
D
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----
V
G
T
---
K
E
A
-
I
K
---------
D
K
L
----
I
E
F
G
F
T
D
E
M
I
A
M
----------------
P
--
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
---
L
N
-
T
--
C
---
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
------
Y
E
E
-
L
S
N
T
D
L
E
F
-----------------------------------
K
F
----
P
--------
E
-------------------------------------------------
P
G
--
Y
L
E
G
V
K
T
------
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
--
G
---
T
S
KP
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
-
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
-
L
----------
D
-----------
K
-----
T
-----------------------------------------------------
P
S
------------------
E
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
59.61
23%
41
- C2 -
-
5KO2
-
MDR1A_MOUSE
B:
[386-1224]
-----
G
N
L
E
F
K
N
I
H
F
--
S
--
Y
-
P
S
RKE
V
Q
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
-------
Q
R
L
Y
D
P
L
D
G
M
V
------
S
I
D
G
-
Q
DIRTINVRYLR
E
I
I
G
V
V
S
Q
E
P
V
-
L
F
-------
A
-
T
-
T
I
A
E
N
I
R
Y
G
R
E
D
V
T
--
M
D
E
I
E
K
A
V
K
E
------------------------------------
A
N
A
Y
D
F
I
M
K
L
P
HQ
F
-
D
T
LV-
G
E
R
--
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
Q
A
T
S
A
L
D
--
T
E
S
E
A
V
V
Q
-
A
A
L
--
D
K
-
A
R-
E
---
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
-
A
D
V
I
A
G
F
D
G
G
V
I
V
-
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
LVMTQT---D
V
P
P
A
S
F
W
R
ILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSK
V
V
GVFT
N
GGPPETQR
Q
NSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQ
D
V
S
W
F
D
D
P
K
N
T
TGALTT
R
L
ANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKML
S
G
-------
Q
A
L
K
DKKELEGSGKIATEAIENFRT
V
V
SLTREQKFET
M
Y
A
Q
S
L
Q
I
P
Y
R
N
A
M
K
K
A
HVFGITFSFTQAMMYFSYAACFRFGAYLVTQ
Q
L
M
T
FENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIR
I
I
E
K
T
P
E
IDSYSTQGL
K
P
N
M
L
E
G
N
V
Q
F
S
G
V
V
F
N
Y
P
--
T
RPS
I
P
--
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
-
Y
D
P
M
A
-
G
S
V
F
L
D
G
K
EIKQLNVQWLR
A
Q
L
G
I
-----
V
S
Q
E
P
I
L
-------------
F
---------
D
C
-----
S
-----------------------------------------------------
I
A
------------------
E
N
I
A
Y
G
----------------------------------------------
D
-----------
N
S
R
V
V
--------------
S
YE------------------------
E
I
V
R
AAKEA
N
I
H
Q
F
I
D
S
L
P
D
K
Y---------
N
T
-
R
V
G
D
K
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
Q
P
H
I
L
L
L
D
Q
A
T
S
A
L
D
T
E
S
E
K
V
V
Q
E
A
L
D
K
A
----
R
EG
R
T
C
I
V
I
A
H
R
L
S
T
I
Q
N
-
A
D
L
I
V
V
I
Q
N
-
G
K
V
K
-
E
-
H
G
T
H
Q
Q
L
L
A
--------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.36
25%
-29
- C2 -
-
2IX3
-
EF3A_YEAST
A:
[440-761]
-----------
E
F
S
L
--
A
--
Y
-
G
A
---
K
I
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
-------
A
------
N
G
Q
V
DGF---
P
T
Q
E
-
E
-----------
C
R
T
V
Y
V
E
H
D
I
----------------------
D
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
----
V
G
T
---
K
E
A
-
I
K
---------
D
K
L
----
I
E
F
G
F
T
D
E
M
I
A
M
----------------
P
--
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
--
T
V
N
V
A
W
L
V
-
N
Y
---
L
N
-
T
--
C
---
G
I
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
------
Y
E
E
-
L
S
N
T
D
L
E
F
-----------------------------------
K
F
----
P
--------
E
-------------------------------------------------
P
G
--
Y
L
E
G
V
K
T
------
K
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
--
G
---
T
S
KP
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
-
S
-
G
E
V
Y
T
H
E
N
-----------
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
-
L
----------
D
-----------
K
-----
T
-----------------------------------------------------
P
S
------------------
E
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.85
28%
-65
- C2 -
-
4YMV
1
?
J:
[2-214]
-------
I
F
V
N
D
V
Y
K
--
N
--
F
-
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
------
F
I
D
G
----------------------
V
K
-
I
N
-------
N
-
G
-
K
V
--
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
------
L
F
P
H
---
L
T
A
-
I
E
N
I
T
L
A
P
V
K
V
K
K
M
----
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
---
K
K
D
QY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
K
E
V
L
-
N
V
M
KQ
L
A
-
N
--
E
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.60
28%
-64
- C2 -
-
4YMW
-
?
J:
[2-214]
-------
I
F
V
N
D
V
Y
K
--
N
--
F
-
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
------
F
I
D
G
----------------------
V
K
-
I
N
-------
N
-
G
-
K
V
--
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
------
L
F
P
H
---
L
T
A
-
I
E
N
I
T
L
A
P
V
K
V
K
K
M
----
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
---
K
K
D
QY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
K
E
V
L
-
N
V
M
KQ
L
A
-
N
--
E
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.57
28%
-63
- C2 -
-
4YMU
1
?
J:
[2-214]
-------
I
F
V
N
D
V
Y
K
--
N
--
F
-
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
------
F
I
D
G
----------------------
V
K
-
I
N
-------
N
-
G
-
K
V
--
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
------
L
F
P
H
---
L
T
A
-
I
E
N
I
T
L
A
P
V
K
V
K
K
M
----
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
---
K
K
D
QY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
K
E
V
L
-
N
V
M
KQ
L
A
-
N
--
E
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.53
28%
-59
- C2 -
-
4YMS
-
?
J:
[2-214]
-------
I
F
V
N
D
V
Y
K
--
N
--
F
-
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
------
F
I
D
G
----------------------
V
K
-
I
N
-------
N
-
G
-
K
V
--
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
------
L
F
P
H
---
L
T
A
-
I
E
N
I
T
L
A
P
V
K
V
K
K
M
----
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
---
K
K
D
QY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
K
E
V
L
-
N
V
M
KQ
L
A
-
N
--
E
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.04
28%
-65
- C2 -
-
4YMT
-
?
J:
[2-214]
-------
I
F
V
N
D
V
Y
K
--
N
--
F
-
G
S
---
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
P
T
K
G
E
V
------
F
I
D
G
----------------------
V
K
-
I
N
-------
N
-
G
-
K
V
--
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
------
L
F
P
H
---
L
T
A
-
I
E
N
I
T
L
A
P
V
K
V
K
K
M
----
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
--
L
-
L
D
---
K
K
D
QY
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
K
E
V
L
-
N
V
M
KQ
L
A
-
N
--
E
---
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
54.41
30%
-42
* C2 *
-
3RLF
2
MALK_ECOLI
A:
[2-219]
-----
A
S
V
Q
L
Q
N
V
T
K
--
A
--
W
-
G
E
---
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
-------
A
G
L
E
T
I
T
S
G
D
L
------
F
I
G
E
-
K
RMNDTPPAE--
R
G
V
G
M
V
F
Q
S
Y
A
-
L
Y
-------
P
-
H
L
S
V
A
E
N
M
S
F
G
L
K
L
A
G
-------------------------------------
A
----
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
--
L
-
A
H
LL-
D
R
K
--
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
--
A
A
L
R
V
Q
M
R
-
I
E
I
--
S
R
-
L
--
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-
V
G
K
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
53.95
23%
13
- C3 -
-
1YQT
2
?
A:
[25-486]
----------
E
D
C
V
H
--
R
--
Y
-
G
V
---
N
A
F
V
L
Y
R
L
P
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
-------
A
G
Q
L
I
P
N
L
C
G
D
------
N
D
S
W
D
G
-----------
V
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
L
K
N
GE
I
-
R
P
V
V
K
P
Q
Y
V
D
L
I
P
K
A
------
V
---------------------
K
G
K
V
I
E
L
L
-------
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
--
L
-
E
N
VL-
E
R
E
--
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
--
I
R
Q
R
L
N
A
A
-
R
A
I
--
R
R
-
L
S
E
E
---
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
-
I
H
V
V
Y
G
E
P
G
V
Y
-
G
I
---
F
S
Q
P
K
G
T
R
N
G
---------------
I
N
E
-----------------------------------
F
L
---------------------------------------------------------------
R
G
Y
L
K
D
E
N
V
R
F
------
R
P
-------------------------------------------------------------------------
Y
---------------------
E
I
-------------
K
F
-
T
K
T
G
E
--------------------------------------
R
V
E
----------------------------------------------------------
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
------
S
F
--
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
-
E
E
P
T
E
-
G
K
I
E
W
D
L
-------------
T
V
A
Y
-----
K
P
Q
Y
I
K
--
A
----------
D
Y
---------
E
G
-----
T
-----------------------------------------------------
V
Y
------------------
E
L
L
S
K
I
----------------------------------------------
D
-----------
A
S
K
L
------------------------------------------
N
S
N
F
-----
Y
K
T
E
L
L
K
P
L
G
I
I
----------
D
--
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
--
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
G
-
E
P
G
K
--
Y
G
R
A
L
-------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.34
28%
-59
- C2 -
-
2YYZ
1
?
A:
[2-215]
-----
P
S
I
R
V
V
N
L
K
K
--
Y
--
F
-
G
K
---
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
-------
A
G
I
Y
K
P
T
S
G
E
I
------
Y
F
D
D
-----------------
V
L
V
N
D
I
P
---------------------
P
K
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
---
I
--------
A
F
P
L
R
A
R
R
I
----
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
--
I
-
D
N
---
L
L
D
RK
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
--
Q
Q
-
E
--
L
---
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
52.20
30%
-35
- C2 -
-
2AWN
1
MALK_ECOLI
B:
[2-219]
-----
A
S
V
Q
L
Q
N
V
T
K
--
A
--
W
-
G
E
---
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
-------
A
G
L
E
T
I
T
S
G
D
L
------
F
I
G
E
-
K
RMNDTPPAE--
R
G
V
G
M
V
F
Q
S
Y
A
-
L
Y
-------
P
-
H
L
S
V
A
E
N
M
S
F
G
L
K
L
A
G
-------------------------------------
A
----
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
--
L
-
A
H
LL-
D
R
K
--
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
--
A
A
L
R
V
Q
M
R
-
I
E
I
--
S
R
-
L
--
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
-
V
G
K
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
35.93
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
A:
[344-556]
---------
F
R
N
V
T
F
--
T
--
Y
-
P
G
REV
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
RFYDID
E
G
H
I
L
M
D
G
H
D
L
REYT
L
A
S
L
R
N
--------------
Q
V
A
L
V
S
Q
N
V
H
-
L
F
-------
N
-
D
-
T
V
A
N
N
I
A
Y
A
R
T
E
---------
E
Y
S
R
E
----
Q
---
I
E
E
-
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
----
D
-----
N
G
L
D
T
I
I
G
E
-----------
N
G
V
--
L
--
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
--
T
E
S
E
R
A
I
Q
-
A
A
L
--
D
E
L
Q
--
K
---
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
35.93
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
B:
[344-556]
---------
F
R
N
V
T
F
--
T
--
Y
-
P
G
REV
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
TRFYDID
E
G
H
I
L
M
D
G
H
D
L
REYTLA
S
L
R
N
--------------
Q
V
A
L
V
S
Q
N
V
H
-
L
F
-------
N
-
D
-
T
V
A
N
N
I
A
Y
A
R
T
E
---------
E
Y
S
R
E
----
Q
---
I
E
E
-
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
----
D
-----
N
G
L
D
T
I
I
G
E
-----------
N
G
V
--
L
--
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
--
T
E
S
E
R
A
I
Q
-
A
A
L
--
D
E
L
Q
--
K
---
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
35.93
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
C:
[344-556]
---------
F
R
N
V
T
F
--
T
--
Y
-
P
G
REV
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
TRFYDID
E
G
H
I
L
M
D
G
H
D
L
REYTLA
S
L
R
N
--------------
Q
V
A
L
V
S
Q
N
V
H
-
L
F
-------
N
-
D
-
T
V
A
N
N
I
A
Y
A
R
T
E
---------
E
Y
S
R
E
----
Q
---
I
E
E
-
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
----
D
-----
N
G
L
D
T
I
I
G
E
-----------
N
G
V
--
L
--
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
--
T
E
S
E
R
A
I
Q
-
A
A
L
--
D
E
L
Q
--
K
---
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
35.93
31%
-
- C2 -
-
3B5Z
2
MSBA_SALTY
D:
[344-556]
---------
F
R
N
V
T
F
--
T
--
Y
-
P
G
REV
P
A
L
R
N
-
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
TRFYDID
E
G
H
I
L
M
D
G
H
D
L
REYTLA
S
L
R
N
--------------
Q
V
A
L
V
S
Q
N
V
H
-
L
F
-------
N
-
D
-
T
V
A
N
N
I
A
Y
A
R
T
E
---------
E
Y
S
R
E
----
Q
---
I
E
E
-
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
----
D
-----
N
G
L
D
T
I
I
G
E
-----------
N
G
V
--
L
--
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
--
T
E
S
E
R
A
I
Q
-
A
A
L
--
D
E
L
Q
--
K
---
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------