@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMS2: (2017-11-10 )
MSKSIEKFPKELVSPIAQLHSLVEKNSKLHIKELFAAEQDRFQNYSVKFDQLVFDYSKHRITKSVLEQLFALAKTKQLTHWIERLFSQDKVNCTEQRAAMHWALRLPSEYSKFPELTKQVHTQLQRMYVLVEKIHAGQYRGATGEVIQDVVNIGVGGSDLGPQMVTHALCDFKVKTAKPLNVHFVSTMDGSQLSDLLHQLRPETTLFIISSKSFGTIDTLSNAQTVRQWLEKALGKHDRVVKSHFIGVSTKAEKMTEWGIAPENQLLLWDWVGGRYSLWSCIGFPIALTIGIDGFQQLLAGAHAVDEHFQNTNFEQNIPVLMALLGIWNNNFLNIQTHAVLPYDGRLKYFAAYLQQLEMESNGKSVQRDGQKVELDTCPIVWGEVGPNAQHAFYQLLHQGTQAVSCDFIAPIQRYNADHFTYVENAEALIEQHHLALSNCLAQSRLLAFGNEALDSAELKNLPIYKQYEGNQPSSTLLLKELNPYSLGMLIALYEHKVFVQSVIWNINPFDQWGVEKGKQIADQLLPILNGAQNDLSALDASTRGLIKILLGKVDG
Atome Classification :
(54 SA)
----------------------------------.........10.----------.......20...-.....30........40.....-.-.----.50------.------...-.....60........70........80........90........100--....---.-.--..--110--..---.------.---....120.......130.......140.......150.......160.......170.......-..180....-....190.......200.......210.......220.......230.....----.----.----240.......250.----.......260.......270.......280.-.-.....290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.-----...--...420.......430--.......-..440.......450---------.----..-----------....------..-----------460---------....--------.....470.......480.......490.......500.......510.......520.......530...-.-------...540.......550....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------MSK
S
I
E
K
F
P
K
E
L
----------
V
S
P
I
A
Q
L
H
S
L
V
E
-KNSK
L
H
I
K
E
L
F
A
A
E
Q
D
R
FQNYS-V-
K
----
F
D
-------
Q
------
L
V
F
-
D
Y
S
K
H
R
I
T
K
S
V
L
E
Q
L
F
A
L
A
K
T
K
Q
L
T
H
W
I
E
R
L
F
SQDKV
N
C
T
E
Q
R
A
A
M
H
---
W
ALR---L-
P
--
S
E
--
Y
S
---
K
F
---
P
------
E
---
L
T
K
Q
V
H
T
Q
L
Q
R
M
Y
V
L
V
E
K
IHAGQYRGA
T
G
E
V
I
Q
D
V
V
NIGVGGSDL
G
P
Q
M
V
T
H
A
L
C--DFKVKTA-K
P
L
-
N
V
H
F
V
-STMD
G
S
Q
L
S
D
L
L
H
QLRPE
T
T
L
F
I
I
SSKSFGTIDTLS
N
A
Q
T
V
R
Q
W
L
E
K
A
LGK
H
----
D
----
R
----
V
V
K
S
HFIGVS
T
-
K
A
----
E
K
M
T
EWGIAPEN
Q
L
L
L
W
DWVGGR
Y
S
L
W
S
CIG-F-
P
I
A
L
T
I
G
I
D
G
F
Q
Q
L
L
A
G
A
H
A
V
D
E
H
FQNTNFEQ
N
I
P
V
L
M
A
L
L
G
IWNN
N
F
L
N
I
Q
T
H
A
VLPYDG
R
L
K
Y
F
A
A
Y
L
Q
Q
L
E
MESNGKSVQRDG
Q
K
V
ELDTC
P
I
V
WGEVGPN
A
Q
H
A
F
Y
Q
L
L
H
QGT
Q
A
VSCDFIA
P
I
Q
-----RYN--ADH
F
T
Y
V
E
N
A
E
A
L
I
----
E
Q
H
H
L
A
L
-
S
N
C
L
A
Q
S
R
L
L
A
F
G
-----------
N
----EA-----------L
D
S
A
------EL-----------K-----------NL
P
I
--------
Y
K
QYEGNQPS
S
T
L
L
L
KELNP
Y
S
L
G
M
L
I
A
L
Y
E
H
K
V
F
V
Q
S
V
IWNIN
P
F
D
Q
W
G
V
E
K
G
K
Q
I
A
D
Q
L
L
P
I
LNGAQ
N
D
-
L
-------
S
A
L
D
A
S
T
R
G
L
I
K
I
L
L
GKVDG-
22
PsiBlast_CBE
89.17
47%
-37
- C6 -
-
3HJB
8
G6PI_VIBCH
D:
[45-567]
-------------------------------------------------------------------
E
-
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
-
A
-
R
----
F
G
-------
Q
D-----
I
L
V
-
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
---
T
A
L
R
---
N
-
R
--
S
N
--
S
P
---
V
L
VNG
E
------
D
---
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
--
P
Y
K
-----
N
H
L
-
T
V
H
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
F
L
K
A
A
G
D
E
----
A
----
H
----
V
A
K
-
H
F
A
A
L
S
T
-
N
G
----
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
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I
I
L
S
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Y
D
N
F
V
E
L
L
A
G
A
H
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M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
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G
I
W
Y
N
N
F
H
G
A
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S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
-----
S
H
N
--------------
L
V
----
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
-----------
K
----
S
A
QAVQAELEKAG
K
S
A
A
------
E
I
-----------
A
-----------
A
L
V
P
--------
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
S
A
-
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
N
---------
2
PsiBlast_PDB
88.90
47%
-35
- C6 -
-
3HJB
1
G6PI_VIBCH
A:
[45-567]
-------------------------------------------------------------------
E
-
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
-
A
-
R
----
F
G
-------
Q
D-----
I
L
V
-
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
---
T
A
L
R
---
N
-
R
--
S
N
--
S
P
---
V
L
V
NG
E
------
D
---
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
--
P
Y
K
-----
N
H
L
-
T
V
H
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
F
L
K
A
A
G
D
E
----
A
----
H
----
V
A
K
-
H
F
A
A
L
S
T
-
N
G
----
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
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Y
D
N
F
V
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L
L
A
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A
H
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D
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V
N
T
P
F
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S
N
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P
V
I
L
A
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G
I
W
Y
N
N
F
H
G
A
E
S
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A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
-----
S
H
N
--------------
L
V
----
G
D
H
H
Q
K
L
M
S
N
F
F
A
Q
T
E
A
L
A
F
G
-----------
K
----
S
A
Q
A
V
Q
A
E
L
E
K
A
G
K
S
A
A
------
E
I
-----------
A
-----------
A
L
V
P
--------
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
S
A
-
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
N
---------
1
PsiBlast_PDB
88.10
48%
-25
- C6 -
-
3NBU
-
G6PI_ECOLI
A:
[27-541]
---------------------------------------------------------------------------
I
A
D
L
F
A
K
D
G
D
R
F
S
K
F
S
-
A
-
T
----
F
D
D------
Q
------
M
L
V
-
D
Y
S
K
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
---
I
L
V
DG
K
------
D
---
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
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I
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K
G
Y
T
G
K
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I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
R
--
P
Y
K
-----
N
H
L
-
N
M
H
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
D
W
F
L
K
A
A
G
D
E
----
K
----
H
----
V
A
K
-
H
F
T
A
L
S
T
-
N
--------
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
A
I
-----
T
H
N
-------------
P
L
S
----
D
H
H
Q
K
L
L
-
S
N
F
F
A
Q
T
E
A
L
A
F
G
K
S
R
E
V
V
E
Q
E
Y
R
D
----
Q
G
-----------
K
D
P
A
------
T
L
-----------
D
-----------
Y
V
V
P
--------
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
D
D
K
-
E
-
I
-------
S
S
H
D
S
S
T
N
G
L
I
----------
55
PsiBlast_CBE
86.23
41%
-39
- C6 -
-
4EM6
1
G6PI_BRUME
C:
[9-544]
------------------------------------------
A
T
K
L
----------
E
A
T
V
A
K
L
K
K
H
W
A
-
E
S
A
P
R
D
M
R
A
A
F
S
A
D
P
G
R
F
G
R
Y
S
-
L
-
C
----
L
D
-------
D
------
L
L
F
-
D
W
S
K
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
---
V
A
L
R
---
D
-
T
--
S
S
--
K
E
---
V
L
---
V
------
D
GHN
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
A
--
P
Y
H
D
E
P
------
R
A
H
F
V
-
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
K
W
V
A
D
T
L
G
------
E
----
A
----
A
V
G
A
H
F
A
A
V
S
T
-
A
L
----
D
K
V
A
A
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
P
V
M
I
A
V
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
H
R
A
I
C
G
Y
G
S
R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
K
-----
G
H
E
------------
P
T
L
D
----
H
Q
H
E
M
L
M
-
A
N
C
L
A
Q
S
E
A
L
M
K
G
RTL--------
D
----
E
A
-----------
R
A
Q
L
------
Q
A
-----------
K
-----------
N
L
P
A
SQVERIAP
H
R
V
F
S
G
N
R
P
S
L
T
L
I
H
D
M
L
D
P
Y
T
L
G
R
L
I
A
L
Y
E
H
R
V
F
V
E
A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
G
K
E
G
--
A
-------
S
G
R
D
A
S
T
Q
G
L
V
----------
93
HHSearch
83.51
42%
-33
- C6 -
-
4EM6
-
G6PI_BRUME
A:
[7-552]
----------------------------------------
R
D
A
T
K
L
----------
E
A
T
V
A
K
L
K
K
H
W
A
-
E
S
A
P
R
D
M
R
A
A
F
S
A
D
P
G
R
F
G
R
Y
S
-
L
-
C
----
L
D
-------
D
------
L
L
F
-
D
W
S
K
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
---
V
A
L
R
DTS
S
-
K
--
E
V
--
L
V
---
D
G
---
H
------
N
---
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
A
--
P
Y
H
D
------
E
P
R
A
H
F
V
-
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
K
W
V
A
D
T
L
G
E
A
--------------
A
V
G
A
H
F
A
A
V
S
T
-
A
L
D
---
K
V
A
A
-
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
P
V
M
I
A
V
-
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
H
R
A
I
C
G
Y
G
S
R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
K
-----
G
-------
H
E
P
T
-----
L
D
----
H
Q
H
E
M
L
M
-
A
N
C
L
A
Q
S
E
A
L
M
K
G
-----------
R
----
T
L
-----------
D
E
A
R
------
A
Q
-----------
L
Q
A
K
NLP
A
S
Q
V
E
R
I
A
P
--------
H
R
V
F
S
G
N
R
P
S
L
T
L
I
H
D
M
L
D
P
Y
T
L
G
R
L
I
A
L
Y
E
H
R
V
F
V
E
A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
G
K
E
G
--
A
-------
S
G
R
D
A
S
T
Q
G
L
V
A
H
L
H
A
R
R
K
--
94
HHSearch
81.58
42%
-34
- C6 -
-
4EM6
1
G6PI_BRUME
C:
[9-552]
------------------------------------------
A
T
K
L
----------
E
A
T
V
A
K
L
K
K
H
W
A
-
E
S
A
P
R
D
M
R
A
A
F
S
A
D
P
G
R
F
G
R
Y
S
-
L
-
C
----
L
D
-------
D
------
L
L
F
-
D
W
S
K
C
R
V
N
D
E
T
M
A
L
L
K
E
L
A
V
A
A
D
V
E
G
R
R
A
A
M
F
A
G
E
H
I
N
N
T
E
D
R
A
V
L
H
---
V
A
L
R
DTS
S
-
K
--
E
V
--
L
V
---
D
G
---
H
------
N
---
V
L
P
D
V
K
H
V
L
D
R
M
A
A
F
A
D
G
I
R
S
G
A
L
K
G
A
T
G
R
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
A
T
L
A
L
A
--
P
Y
H
D
------
E
P
R
A
H
F
V
-
S
N
I
D
G
A
H
I
A
D
T
L
S
P
L
D
P
A
S
T
L
I
I
V
A
S
K
T
F
T
T
I
E
T
M
T
N
A
Q
T
A
R
K
W
V
A
D
T
L
G
E
A
--------------
A
V
G
A
H
F
A
A
V
S
T
-
A
L
D---
K
V
A
A
-
F
G
I
P
E
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
P
V
M
I
A
V
-
G
P
D
N
F
R
K
F
L
A
G
A
H
A
M
D
V
H
F
R
D
A
P
L
E
K
N
L
P
V
M
L
G
L
I
G
Y
W
H
R
A
I
C
G
Y
G
S
R
A
I
I
P
Y
D
Q
R
L
S
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
S
V
T
L
D
G
K
P
V
S
G
P
T
G
P
V
V
W
G
E
P
G
T
N
G
Q
H
A
F
F
Q
L
L
H
Q
G
T
D
T
I
P
L
E
F
I
V
A
A
K
-----
G
-------
H
E
P
T
-----
L
D
----
H
Q
H
E
M
L
M
-
A
N
C
L
A
Q
S
E
A
L
M
K
G
-----------
R
----
T
L
-----------
D
E
A
R
------
A
Q
-----------
L
QAKNLPASQVE
R
I
A
P
--------
H
R
V
F
S
G
N
R
P
S
L
T
L
I
H
D
M
L
D
P
Y
T
L
G
R
L
I
A
L
Y
E
H
R
V
F
V
E
A
Q
I
F
G
I
N
A
F
D
Q
W
G
V
E
L
G
K
E
L
A
T
E
L
L
P
V
V
S
G
K
E
G
--
A
-------
S
G
R
D
A
S
T
Q
G
L
V
A
H
L
H
A
R
R
K
--
92
HHSearch
81.43
42%
-36
- C6 -
-
2WU8
-
G6PI_MYCTU
A:
[3-543]
-------------------------------------------
I
T
A
----------
T
P
A
W
D
A
L
A
R
H
H
D
-
Q
I
G
N
T
H
L
R
Q
F
F
A
D
D
P
G
R
G
R
E
L
T
-
V
-
S
----
V
G
-------
D
------
L
Y
I
-
D
Y
S
K
H
R
V
T
R
E
T
L
A
L
L
I
D
L
A
R
T
A
H
L
E
E
R
R
D
Q
M
F
A
G
V
H
I
N
T
S
E
D
R
A
V
L
H
T
A
L
R
L
P
R
---
D
-
A
--
E
L
--
V
V
---
D
G
---
Q
------
D
---
V
V
T
D
V
H
A
V
L
D
A
M
G
A
F
T
D
R
L
R
S
G
E
W
T
G
A
T
G
K
R
I
S
T
V
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
Y
Q
A
L
R
--
H
Y
A
D
-----
A
G
I
S
A
R
F
V
-
S
N
V
D
P
A
D
L
I
A
T
L
A
D
L
D
P
A
T
T
L
F
I
V
A
S
K
T
F
S
T
L
E
T
L
T
N
A
T
A
A
R
R
W
L
T
D
A
L
G
D
----------
A
----
A
V
S
R
H
F
V
A
V
S
T
-
N
K
----
R
L
V
D
D
F
G
I
N
T
D
N
M
F
G
F
W
D
W
V
G
G
R
Y
S
V
D
S
A
I
G
-
L
-
S
L
M
T
V
I
G
R
D
A
F
A
D
F
L
A
G
F
H
I
I
D
R
H
F
A
T
A
P
L
E
S
N
A
P
V
L
L
G
L
I
G
L
W
Y
S
N
F
F
G
A
Q
S
R
T
V
L
P
Y
S
N
D
L
S
R
F
P
A
Y
L
Q
Q
L
T
M
E
S
N
G
K
S
T
R
A
D
G
S
P
V
S
A
D
T
G
E
I
F
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
L
H
Q
G
T
R
L
V
P
A
D
F
I
G
F
A
Q
-----
P
------
L
D
D
L
P
T
-
A
E
G
T
G
----
S
M
H
D
L
L
M
-
S
N
F
F
A
Q
T
Q
V
L
A
F
G
-----------
K
----
T
A
-----------
E
E
I
A
------
A
D
GTP--------
A
-----------
H
V
V
A
--------
H
K
V
M
P
G
N
R
P
S
T
S
I
L
A
S
R
L
T
P
S
V
L
G
Q
L
I
A
L
Y
E
H
Q
V
F
T
E
G
V
V
W
G
I
D
S
F
D
Q
W
G
V
E
L
G
K
T
Q
A
K
A
L
L
P
V
I
T
G
A
G
S
P
-
P
-------
P
Q
S
D
S
S
T
D
G
L
V
R
R
Y
R
T
E
R
---
85
HHSearch
80.70
47%
-6
- C6 -
-
3NBU
-
G6PI_ECOLI
C:
[1-548]
--------------------------------------
M
K
N
I
N
P
T
Q
----------
T
A
A
W
Q
A
L
Q
K
H
F
D
-
E
M
K
D
V
T
I
A
D
L
F
A
K
D
G
D
R
F
S
K
F
S
-
A
T
F
----
D
D
-------
Q
------
M
L
V
-
D
Y
S
K
N
R
I
T
E
E
T
L
A
K
L
Q
D
L
A
K
E
C
D
L
A
G
A
I
K
S
M
F
S
G
E
K
I
N
R
T
E
N
R
A
V
L
H
VAL
R
N
R
S
---
N
-
T
--
P
I
--
L
V
---
D
G
---
K
------
D
---
V
M
P
E
V
N
A
V
L
E
K
M
K
T
F
S
E
A
I
I
S
G
E
W
K
G
Y
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
R
--
P
Y
K
N
------
H
L
N
M
H
F
V
-
S
N
V
D
G
T
H
I
A
E
V
L
K
K
V
N
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
S
A
R
D
W
F
L
K
A
A
G
D
E
---------
K
----
H
V
A
K
H
F
T
A
L
S
T
-
N
A
----
K
A
V
G
E
F
G
I
D
T
A
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
V
L
S
I
G
F
D
N
F
V
E
L
L
S
G
A
H
A
M
D
K
H
F
S
T
T
P
A
E
K
N
L
P
V
L
L
A
L
I
G
I
W
Y
N
N
F
F
G
A
E
T
E
A
I
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
V
V
D
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
V
P
C
D
F
I
A
P
--------------
A
I
T
H
N
----
P
L
S
----
D
H
H
Q
K
L
L
-
S
N
F
F
A
Q
T
E
A
L
A
F
G
-----------
K
----
S
R
-----------
E
V
V
E
------
Q
E
YRDQGKDPATL
D
-----------
Y
V
V
P
--------
F
K
V
F
E
G
N
R
P
T
N
S
I
L
L
R
E
I
T
P
F
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
T
Q
G
V
I
L
N
I
F
T
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
R
I
L
P
E
L
K
D
D
K
E
--
I
-------
S
S
H
D
S
S
T
N
G
L
I
N
R
Y
K
A
W
R
---
51
PsiBlast_CBE
80.12
43%
2
- C6 -
-
1G98
2
G6PI_RABIT
A:
[19-549]
-------------------------------------------------------------------
E
-
H
G
S
E
L
N
L
R
H
L
F
D
T
D
K
E
R
F
N
H
F
S
-
L
-
T
----
L
N
TNH
G
---
H
------
I
L
L
-
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
I
V
V
D
G
---
K
------
D
---
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
S
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
F
L
L
S
-
A
K
D
----
P
----
S
----
T
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
TQHPI
R
K
G
--
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
----
E
A
L
M
K
G
K
-
S
T
E
E
A
R
K
E
L
Q
A
A
G
-----------
K
----
S
P
-----------
E
D
L
M
------
K
L
------------------------
L
P
---------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
D
G
S
-
S
P
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
N
F
I
-------
89
HHSearch
79.83
45%
-9
- C6 -
-
3HJB
1
G6PI_VIBCH
A:
[24-573]
------------------------------------
A
M
L
K
N
I
N
P
T
Q
----------
T
Q
A
W
K
A
L
T
A
H
F
E
-
S
A
Q
D
M
D
L
K
A
L
F
A
Q
D
S
E
R
F
A
K
Y
S
-
A
R
F
----
G
Q
-------
D
------
I
L
V
-
D
Y
S
K
N
L
V
N
A
E
T
M
Q
H
L
F
A
L
A
K
E
T
D
L
Q
S
A
I
T
A
M
F
K
G
E
A
I
N
Q
T
E
D
R
A
V
L
H
T
A
L
R
N
R
S
---
N
-
S
--
P
V
--
L
V
---
N
G
---
E
------
D
---
V
M
P
A
V
N
A
V
L
A
K
M
K
A
F
S
E
R
V
I
G
G
E
W
K
G
F
T
G
K
A
I
T
D
V
V
N
I
G
I
G
G
S
D
L
G
P
Y
M
V
T
E
A
L
V
--
P
Y
K
N
------
H
L
T
V
H
F
V
-
S
N
V
D
G
T
H
M
A
E
T
L
K
N
V
D
P
E
T
T
L
F
L
V
A
S
K
T
F
T
T
Q
E
T
M
T
N
A
H
T
A
R
D
W
F
L
K
A
A
G
D
E
---------
A
----
H
V
A
K
H
F
A
A
L
S
T
-
N
G
----
K
A
V
A
E
F
G
I
D
T
D
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
I
L
S
I
G
Y
D
N
F
V
E
L
L
A
G
A
H
E
M
D
Q
H
F
V
N
T
P
F
E
S
N
I
P
V
I
L
A
L
I
G
I
W
Y
N
N
F
H
G
A
E
S
E
A
I
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
N
M
E
S
N
G
K
Y
V
D
R
N
G
N
P
V
T
Y
Q
T
G
P
I
I
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
A
P
A
V
-----
S
-------
H
N
L
------
V
G
----
D
H
H
Q
K
L
M
-
S
N
F
F
A
Q
T
E
A
L
A
F
G
-----------
K
----
S
A
-----------
Q
A
V
Q
------
A
E
L
E
K
A
GKS
A
A
E
I
A
-----------
A
L
V
P
--------
F
K
V
F
E
G
N
R
P
T
N
S
I
L
V
K
Q
I
T
P
R
T
L
G
N
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
I
W
N
I
F
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
N
Q
I
L
P
E
L
A
D
S
A
A
--
V
-------
T
S
H
D
S
S
T
N
G
L
I
N
A
F
K
A
F
R
---
29
PsiBlast_CBE
79.83
43%
-1
- C6 -
-
1U0F
7
G6PI_MOUSE
B:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNHG---
H
------
I
L
V
-
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
IKV
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
K
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
E
A
L
M
K
G
KLPEEA-----
R
----
K
E
-----------
L
Q
A
A
GKSPE-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
34
PsiBlast_CBE
79.75
43%
-3
- C6 -
-
2CXT
5
G6PI_MOUSE
A:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNH
G
---
H
------
I
L
V
-
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
I
K
V
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
K
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
E
A
L
M
K
G
KL
P
E
E
A
-----
R
----
K
E
-----------
L
Q
A
A
GKS
P
E
-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
90
HHSearch
79.68
45%
-22
* C6 *
-
3LJK
3
G6PI_FRATT
A:
[11-543]
-----------------------------------------------------------
K
K
Y
L
K
------
E
Q
N
I
N
L
K
N
E
F
D
K
D
D
K
R
V
E
K
F
S
-
L
-
K
----
H
Q
-------
N
------
I
Y
F
-
D
Y
S
K
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
S
T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
---
S
-
T
--
P
L
--
I
V
---
D
G
---
Q
------
D
---
I
R
Q
E
V
T
K
E
K
Q
R
V
K
E
L
V
E
K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
Q
--
P
Y
H
C
-----
T
D
L
K
V
H
F
V
-
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
E
W
L
L
D
H
Y
E
D
E
---------
K
----
A
V
A
N
H
F
V
A
I
S
S
-
K
L
----
D
K
V
K
E
F
G
I
D
L
E
H
C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
W
S
S
I
G
-
M
S
I
A
F
A
-
I
G
Y
D
N
F
E
K
L
L
A
G
A
Y
S
V
D
K
H
F
K
E
T
E
F
S
K
N
I
P
V
I
M
A
L
L
A
S
Y
Y
S
C
T
Y
N
S
Q
S
Q
A
L
L
P
Y
D
E
R
L
C
Y
F
V
D
Y
L
Q
Q
A
D
M
E
S
N
G
K
S
V
N
I
A
G
E
T
V
N
Y
Q
T
G
V
V
L
W
G
G
V
G
T
N
G
Q
H
A
F
H
Q
L
L
H
Q
G
N
I
F
I
P
V
D
F
I
A
I
A
T
-----
S
------
H
H
N
Y
-------
D
----
N
H
Q
Q
A
L
L
-
A
N
C
F
A
Q
S
Q
A
L
M
F
G
-----------
Q
S
Y
D
M
V
Y
-----------
N
E
L
L
------
K
S
GLN--------
E
T
Q
A
K
-------
E
L
A
A
--------
H
K
V
I
P
G
N
R
P
S
T
T
I
L
L
D
E
L
S
P
Y
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
V
Q
G
V
L
W
D
I
N
S
Y
D
Q
W
G
V
E
L
G
K
K
L
G
K
N
I
L
K
A
M
N
D
D
S
S
D
E
Y
-------
Q
N
L
D
D
S
T
R
Q
L
I
A
K
V
K
N
K
----
15
PsiBlast_PDB
79.61
43%
-2
- C6 -
-
2CXN
3
G6PI_MOUSE
A:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNH
G
---
H
------
I
L
V
-
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
I
K
V
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
K
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
E
A
L
M
K
G
KL
P
E
E
A
-----
R
----
K
E
-----------
L
Q
A
A
GKS
P
E
-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
30
PsiBlast_CBE
79.56
43%
-1
- C6 -
-
1U0E
3
G6PI_MOUSE
B:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNHG---
H
------
I
L
V
-
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
IKV
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
K
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
E
A
L
M
K
G
KLPEEA-----
R
----
K
E
-----------
L
Q
A
A
GKSPE-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
31
PsiBlast_CBE
79.45
43%
-1
- C6 -
-
2CXU
3
G6PI_MOUSE
B:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNHG---
H
------
I
L
V
-
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
IKV
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
K
--
P
Y
S
K
G
G
P
-
R
----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
F
L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
E
A
L
M
K
G
KLPEEA-----
R
----
K
E
-----------
L
Q
A
A
GKSPE-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
K
K
I
E
P
E
L
E
G
S
-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
66
PsiBlast_CBE
79.35
42%
6
- C6 -
-
4QFH
2
?
B:
[67-610]
-------------------------------------------------------------
R
L
Q
E
L
Y
E
-
I
H
G
S
E
S
I
L
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
-
L
-
E
----
V
D
LRSSDK-
N
------
F
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
---
I
A
L
R
---
N
-
R
--
S
N
--
R
P
---
I
F
---
V
NGH---
D
---
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
R
--
P
F
---
S
D
-
R
R
I
-
S
M
H
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
F
L
K
F
L
S
S
R
----
G
ISEA
G
----
A
V
A
K
H
F
V
A
L
S
T
-
N
A
----
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
A
I
Q
-----
T
Q
N
-------
Y
I
G
----------
E
H
H
R
I
L
M
-
S
N
F
F
A
Q
T
E
A
L
M
I
G
KT
P
E
E
V
-----
K
----
R
E
-----------
L
E
S
A
GGKS
E
D
E
I
-----------
Q
-----------
L
L
I
P
--------
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
K
S
I
L
L
Q
L
Q
P
G
Q
K
--
V
-------
T
N
H
D
S
S
T
N
G
L
I
E
L
F
-------
37
PsiBlast_CBE
79.19
43%
-2
- C6 -
-
2CXQ
5
G6PI_MOUSE
B:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNHG---
H
------
I
L
V
-
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
---
V
A
L
R
---
N
-
R
--
S
N
--
T
P
IKV
D
G
---
K
------
D
---
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
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G
D
W
K
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T
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K
S
I
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D
I
I
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I
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I
G
G
S
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L
G
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L
M
V
T
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A
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K
--
P
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K
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G
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-
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----
V
W
F
V
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N
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L
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S
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I
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I
T
N
A
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T
A
K
E
W
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L
E
A
-
A
K
D
----
P
----
S
----
A
V
A
K
H
F
V
A
L
S
T
-
N
T
----
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
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L
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L
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N
A
P
V
L
L
A
L
L
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I
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A
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L
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Y
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F
A
A
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Y
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L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
P
V
Q
--------------
T
Q
H
P
I
R
K
G
L
------
H
H
K
I
L
L
-
A
N
F
L
A
Q
T
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A
L
M
K
G
KLPEEA-----
R
----
K
E
-----------
L
Q
A
A
GKSPE-
D
L
-----------
E
-----------
K
L
L
P
--------
H
K
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N
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P
T
N
S
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L
T
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-
S
A
-
V
-------
T
S
H
D
S
S
T
N
G
L
I
S
F
I
-------
20
PsiBlast_PDB
79.17
43%
-2
- C6 -
-
2CXS
5
G6PI_MOUSE
A:
[21-549]
----------------------------------------------------------------------
S
A
N
L
K
L
R
E
L
F
E
A
D
P
E
R
F
N
N
F
S
-
L
-
N
----
L
N
TNH
G
---
H
------
I
L
V
-
D
Y
S
K
N
L
V
S
K
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M
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---
V
A
L
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---
N
-
R
--
S
N
--
T
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G
---
K
------
D
---
V
M
P
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V
N
R
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--
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----
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W
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--------------
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------
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H
K
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A
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S
-
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A
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-------
T
S
H
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S
S
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N
G
L
I
S
F
I
-------