@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VN67: (2017-11-12 )
MDTQHSALNARKQQATPRGVGVMCQWYAEKAENATIWDKEGNQFIDFAGGIAVLNTGHRHPKVIAAVTEQLTKFTHTAYQVTPYESYVALAERINERAPIAGPAKAAFFTTGAEAVENAVKIARCYTGRHGIITFGNGFHGRSFMTMAMTGKTAPYKRDFGVMPAGVFHARYPVPAKGISVDAAIESVEDIFSEDIAPHDVAVIVLEPVQGEGGFNVVPAEFLKRLRAICDKHGILLVADEVQSGFARTGKLFAMNHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGSPIAVAAAHAVIDAIEEENLCDRANELGAELVATLKDIQQATGDVVTDIRALGSMVAVELETAEQAKVVQNYAMENGLLLLTCGKYGNVIRFLYPLTIPAEQFRQGLDILKQGFATLKAGSAKAMEQSA
Atome Classification :
(46 SA)
.........10........20........30........40........50.......-.60........70.......----.80-..-----......-90........100.......110.......120.....--------.-.-----130----........140.......150.......160.......170.......180---------.........190.....------...200.......210.......220.........230.......240.......250.......260.......270..-.....280-........290.......300.......310.......320.......330.......340.......350.......360----....--....370-.---.-.---....380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDT
Q
H
S
A
L
N
A
R
K
QQATPRG
V
G
V
M
C
Q
W
Y
A
E
KAEN
A
T
I
WDKEG
N
Q
F
I
DFAG
G
I
A
V
LNTGH-RH
P
K
V
I
A
A
V
T
E
Q
L
T
K
F
THT
A
----
Y
Q
V-T
P
-----
Y
E
S
Y
V
A
-
L
A
E
R
I
NERAPIAGPA
K
A
A
F
FTT
G
A
E
A
V
E
N
A
V
K
I
A
R
C
YT--------G-R-----H
G
-----
I
I
TFGNGFHG
R
S
F
M
T
M
A
MTGKTAPYKRDFGVMPAG
V
F
HARYPVPAKGI
S
-----------
V
D
A
A
I
E
S
V
E
D
-
I
F
SEDI------APH
D
V
A
V
I
V
L
EPVQGEGGFNV
V
P
A
--
E
F
L
K
R
L
R
A
I
C
D
KH
G
I
L
L
V
A
D
E
V
QS
G
F
ART
G
K
L
F
A
M
NHYE
T
K
A
D
L
I
T
M
A
K
SLGGG-FPISGVV--GR
A
E
VMDAPNPGGLGGTYAGS
P
I
A
V
A
A
A
H
A
V
I
D
A
I
E
E
E
N
L
C
D
R
A
N
E
L
G
A
E
L
V
A
T
L
K
D
I
Q
Q
A
T
G
D
V
V
T
D
I
R
A
L
G
S
M
V
A
V
E
L-----E
T
A
E
--
Q
A
K
V
V
Q
N
-
Y
---A-M---EN
G
L
L
L
L
T
CGKYG
N
V
I
R
F
L
YPLTI
P
A
E
Q
F
R
Q
G
L
D
I
L
K
Q
G
F
A
T
LKAGS
A
K
A
MEQSA
23
PsiBlast_CBE
98.54
52%
-83
- C1 -
-
1SFF
4
GABT_ECOLI
B:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
34
PsiBlast_CBE
98.47
52%
-82
- C1 -
-
1SZS
11
GABT_ECOLI
C:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
25
PsiBlast_CBE
98.13
52%
-82
- C1 -
-
1SF2
5
GABT_ECOLI
C:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
24
PsiBlast_CBE
98.05
52%
-82
- C1 -
-
1SF2
9
GABT_ECOLI
D:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
33
PsiBlast_CBE
97.90
52%
-82
- C1 -
-
1SZS
12
GABT_ECOLI
D:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
32
PsiBlast_CBE
97.73
52%
-81
- C1 -
-
1SZK
3
GABT_ECOLI
B:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
21
PsiBlast_CBE
97.64
52%
-82
- C1 -
-
1SFF
11
GABT_ECOLI
D:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
28
PsiBlast_CBE
97.61
52%
-82
- C1 -
-
1SZU
12
GABT_ECOLI
C:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
2
PsiBlast_PDB
97.44
52%
-80
- C1 -
-
1SFF
6
GABT_ECOLI
A:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
EDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
V
A
R
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
30
PsiBlast_CBE
97.11
52%
-80
- C1 -
-
1SZK
11
GABT_ECOLI
D:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
26
PsiBlast_CBE
97.04
52%
-82
- C1 -
-
1SF2
8
GABT_ECOLI
B:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
35
PsiBlast_CBE
96.99
52%
-80
- C1 -
-
1SZS
3
GABT_ECOLI
B:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
22
PsiBlast_CBE
96.96
52%
-81
- C1 -
-
1SFF
12
GABT_ECOLI
C:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
29
PsiBlast_CBE
96.65
52%
-80
- C1 -
-
1SZU
5
GABT_ECOLI
B:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
5
PsiBlast_PDB
96.51
52%
-80
- C1 -
-
1SZS
2
GABT_ECOLI
A:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
EDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
V
A
R
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
31
PsiBlast_CBE
96.36
52%
-81
- C1 -
-
1SZK
10
GABT_ECOLI
C:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
27
PsiBlast_CBE
96.32
52%
-82
- C1 -
-
1SZU
13
GABT_ECOLI
D:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
FEDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
VAR
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
1
PsiBlast_PDB
96.13
52%
-80
- C1 -
-
1SF2
4
GABT_ECOLI
A:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
DGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
V
A
R
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
3
PsiBlast_PDB
96.08
52%
-80
- C1 -
-
1SZU
4
GABT_ECOLI
A:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
EDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
V
A
R
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
4
PsiBlast_PDB
96.07
52%
-80
- C1 -
-
1SZK
2
GABT_ECOLI
A:
[7-425]
-------
L
M
Q
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
----
F
Q
V
-
L
A
-----
Y
E
P
Y
L
E
-
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
T
--------
K
-
R
-----
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
P
C
P
L
H
G
I
S
-----------
E
D
D
A
I
A
S
I
H
R
-
I
F
K
N
D
A
------
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
--
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
--
G
R
A
E
V
M
D
A
V
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
-
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
EDGD
H
N
K
P
--
D
A
K
L
T
A
E
-
I
V
A
R
A
-
R
---
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
-----------
123
HHSearch
65.08
35%
-10
* C1 *
-
4JEV
2
ARGD_SALTY
B:
[38-420]
----------------------
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
A
T
F
---
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
CVRHSP--
F
-
K
-----
T
K
-----
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
-
V
M
D
-----------
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
KG
R
A
R
D
F
L
Y
-
A
---
G
-
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
----------
118
HHSearch
63.19
35%
-13
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[38-420]
----------------------
P
A
D
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
A
T
F
---
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSP--
F
-
K
-----
T
K
-----
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
-
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
N
D
---------------------
L
H
A
V
K
A
-
V
M
D
-----------
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
KG
R
A
R
D
F
L
Y
-
A
---
G
-
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
A
----------
79
PsiBlast_CBE
58.68
34%
-3
- C1 -
-
2E54
3
ARGD_THEMA
A:
[22-380]
-----------------------------------
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
A
E
K
L
I
H
C
S
-----
N
L
-
F
W
-----
N
R
P
Q
M
E
-
L
A
E
L
L
S
K
N
T
-
F
G
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
Y
G
--------
K
-
K
K
SEKK
Y
R
-----
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
G
Q
P
K
-
Y
Q
K
P
F
E
P
L
V
P
G
F
E
Y
F
E
F
------------------------
N
N
V
E
D
-
L
R
R
K
--------
M
S
E
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
--
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
A
N
V
L
E
---
P
G
D
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
-
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
-----
R
E
E
V
--
S
N
R
E
V
A
T
-
K
---
C
-
F
---
E
N
K
L
L
V
V
P
A
G
N
--
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
-----------------
74
PsiBlast_CBE
56.59
36%
-11
- C1 -
-
4JEY
8
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
----
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
16
PsiBlast_PDB
56.59
35%
3
- C1 -
-
2EO5
2
?
A:
[29-418]
----------------------------
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
M
Q
K
L
A
H
A
A
ANDF
Y
N
I
-
P
Q
-----
L
E
-----
L
A
K
K
L
V
T
Y
S
P
G
N
F
Q
K
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-
T
--------
G
-
R
-----
K
Y
-----
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
P
F
M
P
G
V
I
H
V
P
Y
P
N
P
Y
R
N
P
W
HINGYEN
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
F
V
N
L
V
------
P
P
E
E
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
--
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
--
F
R
K
D
-
L
D
F
-
K
------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
--
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
----
Q
G
L
A
D
---
D
V
R
G
I
G
L
A
W
G
L
E
Y
-----
N
E
K
K
--
V
R
D
R
I
I
G
-
E
---
S
-
F
---
K
R
G
L
L
L
L
P
A
G
R
--
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
V
V
------------
71
PsiBlast_CBE
55.92
36%
-3
- C1 -
-
4JF1
6
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
73
PsiBlast_CBE
55.82
36%
-6
- C1 -
-
4JEY
9
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
64
PsiBlast_CBE
55.76
36%
-11
- C1 -
-
2PB2
6
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
----
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
68
PsiBlast_CBE
55.47
36%
-9
- C1 -
-
4JEW
8
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
67
PsiBlast_CBE
55.07
36%
-2
- C1 -
-
4JEW
9
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
70
PsiBlast_CBE
54.51
36%
-10
- C1 -
-
4JEX
8
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
69
PsiBlast_CBE
54.29
36%
-8
- C1 -
-
4JEX
8
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
66
PsiBlast_CBE
54.00
36%
-9
- C1 -
-
2PB0
5
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
65
PsiBlast_CBE
53.96
36%
-4
- C1 -
-
2PB0
5
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
H
V
G
S
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
62
PsiBlast_CBE
53.92
36%
-6
- C1 -
-
4JEZ
6
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
R
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
72
PsiBlast_CBE
53.83
36%
-9
- C1 -
-
4JF1
6
ARGD_SALTY
A:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
N
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
97
PsiBlast_CBE
53.58
33%
10
- C1 -
-
1WKH
2
LYSJ_THET8
A:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
101
PsiBlast_CBE
53.05
33%
12
- C1 -
-
1VEF
2
LYSJ_THET8
A:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
99
PsiBlast_CBE
52.95
33%
11
- C1 -
-
1WKG
2
LYSJ_THET8
A:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
61
PsiBlast_CBE
52.92
36%
-7
- C1 -
-
4JEZ
6
ARGD_SALTY
B:
[45-413]
-----------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
-----
R
V
-
F
T
-----
N
E
P
A
L
R
-
L
G
R
K
L
I
D
-
A
T
F
A
--
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
--------
C
V
R
-----
H
S
PFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
----
V
P
F
N
D
L
H
--------------
A
V
K
A
V
M
D
--------------
D
H
T
C
A
V
V
V
-
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
--
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
--
T
T
Q
E
I
A
S
A
F
-----
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
-
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-----
K
P
K
Y
--
K
G
R
A
R
D
F
L
Y
---
A
G
A
---
E
A
G
V
M
V
L
N
A
G
--
A
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
-----------------
78
PsiBlast_CBE
52.10
33%
6
- C1 -
-
2EH6
2
ARGD_AQUAE
A:
[16-373]
-----------------------------
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
S
NL--
Y
E
--
N
P
-----
W
Q
E
--
E
-
L
A
H
K
L
V
K
H
F
W
T
E
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
--------
R
-
D
-----
K
G
KNKW
K
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
---
G
F
E
P
L
--------
V
P
G
F
S
Y
A
-----------
K
L
N
D
I
D
S
V
Y
K
-
L
L
D
E
E
T
------
A
G
-----
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
--
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
--
A
R
E
E
V
A
Q
S
F
T
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
G
K
------
V
K
G
R
G
L
M
L
G
L
E
L
-----
E
R
E
C
--
K
D
Y
V
L
K
------
A
-
L
---
E
K
G
-
L
L
I
N
C
T
A
-
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
-----------------
96
PsiBlast_CBE
51.96
33%
10
- C1 -
-
1WKH
2
LYSJ_THET8
B:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
MRGEF
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
EALKRA
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
76
PsiBlast_CBE
51.54
31%
-7
- C1 -
-
5VIU
9
?
A:
[38-414]
----------------------------
D
R
G
E
G
V
F
V
W
D
V
E
G
K
K
Y
Y
D
F
L
S
A
Y
S
A
V
N
Q
G
H
-
S
H
P
K
I
V
E
A
L
V
E
Q
A
S
K
L
A
L
T
S
----
R
A
F
--------
Y
N
S
--
K
-
L
G
E
Y
E
Q
K
I
T
S
L
L
G
F
D
K
V
L
P
M
N
S
G
A
E
A
V
E
T
A
V
K
L
A
R
K
W
S
Y
EVKGIAE
N
-
A
-----
A
K
-----
I
I
V
C
E
N
N
F
H
G
R
T
-
T
T
I
--
F
S
N
D
P
D
-----
G
P
F
T
P
G
F
I
R
I
P
Y
---------------------
N
D
I
A
A
L
E
E
-
V
L
S
K
E
A
------
G
--
N
I
A
A
F
L
V
E
P
I
Q
G
E
A
G
V
Y
V
P
N
E
--
G
F
L
K
Q
S
S
E
L
C
K
K
H
N
V
L
F
I
A
D
E
V
Q
T
G
I
A
R
T
G
K
L
I
A
C
H
H
E
D
V
Q
P
D
I
L
I
L
G
K
A
L
S
G
G
M
Y
P
V
S
A
V
L
--
A
N
N
N
I
M
D
V
I
K
P
G
Q
H
G
S
T
F
G
G
N
P
L
A
C
A
V
A
M
A
A
L
D
V
V
Q
D
E
K
L
S
E
R
A
E
K
L
G
N
L
F
R
S
E
I
E
K
L
I
E
K
T
-
D
L
I
T
K
V
R
G
K
G
L
L
N
A
I
L
I
-----
N
D
T
P
--
D
S
S
T
A
W
N
-
L
---
C
-
L
A
L
K
E
N
G
--
L
L
A
K
P
T
H
G
N
I
I
R
L
A
P
P
L
V
I
T
E
E
Q
L
L
D
C
V
K
I
I
E
K
-----------------
98
PsiBlast_CBE
51.43
33%
10
- C1 -
-
1WKG
2
LYSJ_THET8
B:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
MRGEF
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
EALKRA
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
100
PsiBlast_CBE
50.85
33%
12
- C1 -
-
1VEF
2
LYSJ_THET8
B:
[33-391]
-----------------------------
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
----
Q
T
L
P
T
P
MRGEF
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
V
---------
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
--------
G
-
R
-----
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
-
Y
R
E
P
F
--
L
P
L
------------------------------
V
E
P
V
E
F
-
I
P
Y
N
D
V
EALKRA
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
--
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
--
M
R
E
E
V
A
R
S
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
---
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
-----
K
E
-
K
--
A
A
P
Y
I
A
R
-
L
---
E
-
K
---
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
------------------
77
PsiBlast_CBE
49.77
33%
6
- C1 -
-
2EH6
2
ARGD_AQUAE
B:
[16-373]
-----------------------------
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
V
E
K
L
L
H
V
S
NL--
Y
E
--
N
P
-----
W
Q
E
--
E
-
L
A
H
K
L
V
K
H
F
W
T
E
G
--
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
--------
R
-
D
-----
K
G
KNKWK
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
G
Q
P
K
F
H
K
---
G
F
E
P
L
--------
V
P
G
F
S
Y
A
-----------
K
L
N
D
I
D
S
V
Y
K
-
L
L
D
E
E
T
------
A
G
-----
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
--
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
--
A
R
E
E
V
A
Q
S
F
T
P
G
S
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
V
D
E
V
E
K
--
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
G
K
------
V
K
G
R
G
L
M
L
G
L
E
L
-----
E
R
E
C
--
K
D
Y
V
L
K
------
A
-
L
---
E
K
G
-
L
L
I
N
C
T
A
-
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
-----------------