@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTM2: (2017-12-14 )
MAQAKKSVDIKNIRNFSIIAHIDHGKSTLADRFIQMCGGLQDREMQAQVLDSMELERERGITIKAASVTLYYTHPNGQEYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAAQGVEAQSVANCYTAIEQGLEVLPILNKIDLPQAEPERVIHEIEEIIGIEATNAPTCSAKTGLGVEGVLETLVDVIPAPTGDREAPLQALIIDSWFDNYLGVVSLVRIKDGRIRKGDKMLVKSTGQTHIVTSVGVFNPKHTETGVLEAGEVGFVIAGIKDIFGAPVGDTITLSTTPEVASLPGFKKVKPQVYAGLFPIDASDFEPFREALQKLQINDSALFFEPESSDALGFGFRCGFLGMLHMEIVQERLEREYDLDLISSAPTVVYEAVTKKGDTIYIDSPSKMPDGSVVEDLREPIAECHILVPQEYLGNVMILCIERRGVQKDMKFLGNQVSITFEIPMAEVVMDFFDKLKSCSRGFASLDYNFIRFESSSLVKVDVLINGEKVDALAMICHRNDARHRGIALVDKMKDLIPRQMFDVAIQAAIGAQIIARSTVKAMRKNVLAKCYGGDVSRKKKLLAKQKEGKKRMKQVGSVEIPQEAFLAVLKVER
Atome Classification :
(27 SA)
.........10........20........30........40.-.--.--------.....50........60........70.-----------...--....80........90........100.......110.......120.......130.......140......----.-----------150------.-------...----.--------------------..---------------------------------------------------.--------------------------------------------------------160--------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------.----------------.--.--...----------------------------------..170...-------------------------------------------------------------------------------------------------------------..----------------------------------------------------------------------------------------------.----------.--------------------------------------------------------------------------------------------------------------..180----------.........190------.------------------.---------------------------.------------------------------------....200.......--------------------------------------------------------------------------------210-.......220.......230-......---------------------------.------------------240--........250..-...-...260.......270.......280......-.-290--......-.-.-.-300.---...-...310..-------.--..---..320.....---..330...-.--...340.......350.......360.......-370..-----.....380......--------------.----------------------------------------------390----------------------------.------.------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------..-----.-...400-------------------.----------------------------------.------------------------------------------------------------------------------.......410.......420.......430....-...440...--....450.......460.......470.......480.--.....---.490....-------.....500.--......510.......520---.......530.......540-.-..--..---...550----------......-----------..-.560----..---...-...570....--...580.......590.......600...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQAKKSV
D
I
KNIRN
F
S
I
I
A
H
IDHG
K
S
T
L
A
D
R
F
I
Q
M
CGGLQ
D
-
R
--
E
--------
M
Q
A
Q
V
L
D
S
M
E
L
E
RER
G
I
T
I
K
A
A
S
V
T
L
Y
Y
-----------THP--NG
Q
E
Y
Q
L
N
F
IDTPG
H
V
D
F
S
Y
E
V
S
R
S
L
A
ACE
G
A
L
L
V
V
DAAQGV
E
A
Q
S
V
A
N
C
Y
T
A
I
E
Q
G
L
E
V
L
P
I
L
N
KIDLPQA
E
----
P
-----------
E
R
-------
V
-------
I
H
E
----
I
--------------------
E
E
---------------------------------------------------
I
--------------------------------------------------------I----------------------------------------------------------------------------------------------G-----------------------------------------------------------------------------------------------I----------------E--A--TNA----------------------------------PTC--SAK-------------------------------------------------------------------------------------------------------------TG----------------------------------------------------------------------------------------------L----------
G
--------------------------------------------------------------------------------------------------------------
V
E
G
------------
V
L
E
T
L
V
D
VIPAP------T------------------G---------------------------D------------------------------------REAP
L
Q
A
L
I
I
D
S
W
F
--------------------------------------------------------------------------------
D
N
Y
-
L
G
V
V
S
L
V
R
IKDGRIRKG
D
K
M
-
L
V
KSTG---------------------------Q------------------
T
H
---
I
V
T
S
VGVFNP-KH-TET-GVLEAGE
V
G
F
V
I
A
G
I
K
D
I
FGAPVG
D
T
I
T
LSTT-P-E----VASLPG-F-K-K-VKP
Q
---
V
Y
A
-
G
L
FPIDAS-------
D
--
F
E
---
P
F
R
E
A
L
Q
KLQ---IND
S
A
L
F
F-E--PESSDALG
F
G
F
R
C
G
F
L
G
M
L
H
M
E
I
V
Q
E
R
L
E
R
E
YD-
L
D
L
IS-----SA
P
T
V
V
Y
E
A
VTKKG--------------
D
----------------------------------------------
T
------------------------------
I
------
Y
------------------------------------------------------------------I---------------------------------------------------------------------------------------------------------------------------DS-----P-SKMP---------------------
D
----------------------------------
G
------------------------------------------------------------------------------
S
V
V
E
D
L
R
E
P
I
A
E
C
H
I
LV
P
Q
E
YLG
N
V
M
I
L
C
I
ERRG-
V
Q
K
D
M
K
F
LG--
N
Q
V
S
I
T
F
EI
P
M
A
E
V
V
M
D
F
F
D
K
L
K
S
C
S
R
G
F
A
SLD
Y
N
F
I
R
--FESS
S
---
L
V
--
K
V
D
V
-------
L
I
NGE
K
V
D
A
--
L
A
M
I
CHRNDARHR
G
I
A
L
V
D
---
K
M
K
D
L
I
P
R
Q
M
F
D
V
A
I
Q
A
A
I--
G
-
A
Q
--
I
I
---
A
R
S
T
------------
V
K
A
M
R
K
-----------
N
V
-
L
A
K
-----CY---GG
D
-
V
S
R
K
K
K
L
L
A
K
--
Q
K
E
G
K
K
R
M
K
QVGSVEI
P
Q
E
A
F
L
A
V
L
KVER
93
Fugue
97.53
70%
-121
- C1 -
-
3CB4
-
LEPA_ECOLI
A:
[1-555]
---------
M
K
N
I
R
N
F
S
I
I
A
H
I
----
S
T
L
S
D
R
I
I
Q
I
C
G
G
-------------------------------------
Q
S
V
T
L
D
Y
-----------
K
A
S
--
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
----
P
-----------
E
R
-------
V
-------
A
E
E
----
I
--------------------
E
D
---------------------------------------------------
I
--------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------
I
----------------
D
--
A
--
T
D
A
----------------------------------
V
R
C
--
S
A
K
-------------------------------------------------------------------------------------------------------------
T
G
----------------------------------------------------------------------------------------------
V
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
D
------------
V
L
E
R
L
V
R
D
I
P
P
P
------
E
------------------
G
---------------------------
D
------------------------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
--------------------------------------------------------------------------------
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
-
K
V
M
S
T
G
---------------------------
Q
------------------
T
Y
---
N
A
D
R
L
G
I
F
T
P
-
K
Q
-
V
D
R
-
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
D
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
-
A
----
E
K
A
L
P
G
-
F
-
K
-
K
-
V
K
P
Q
---
V
Y
A
-
G
L
F
P
V
S
S
D
-------
D
--
Y
E
---
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
-
E
--
P
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
D
-
L
D
L
I
T
-----
T
A
P
T
V
V
Y
E
V
E
T
T
S
R
--------------
E
----------------------------------------------
V
------------------------------
I
------
Y
------------------------------------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------
D
S
-----
P
-
S
K
L
P
---------------------
A
----------------------------------
V
------------------------------------------------------------------------------
N
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
--
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
D
---
M
V
--
R
V
D
V
-------
L
I
N
G
E
R
V
D
A
--
L
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
---
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
--
G
-
T
H
--
I
I
---
A
R
S
T
------------
V
K
Q
L
R
K
-----------
N
V
-
L
A
K
-----
C
Y
---
G
--------------------------------------------
64
HHSearch
95.51
72%
-102
- C1 -
-
3DEG
-
LEPA_ECOLI
C:
[2-545]
----------
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
Q
I
C
G
G
L
S
D
-
R
--
E
--------
M
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
K
A
Q
S
V
T
L
D
Y
-----------
K
A
S
--
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
----
P
-----------
E
R
-------
V
-------
A
E
E
----
I
--------------------
E
D
---------------------------------------------------
I
--------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------
I
----------------
D
--
A
--
T
D
A
----------------------------------
V
R
C
--
S
A
K
-------------------------------------------------------------------------------------------------------------
T
G
----------------------------------------------------------------------------------------------
V
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
D
------------
V
L
E
R
L
V
R
D
I
P
P
P
------
E
------------------
G
---------------------------
D
------------------------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
--------------------------------------------------------------------------------
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
-
K
V
M
S
T
G
---------------------------
Q
------------------
T
Y
---
N
A
D
R
L
G
I
F
T
P
-
K
Q
-
V
D
R
-
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
D
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
-
A
----
E
K
A
L
P
G
-
F
-
K
-
K
-
V
K
P
Q
---
V
Y
A
-
G
L
F
P
V
S
S
D
-------
D
--
Y
E
---
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
-
E
--
P
E
S
S
S
A
L
G
F
G
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y
D
-
L
D
L
I
T
-----
T
A
P
T
V
V
Y
E
V
E
T
T
S
R
--------------
E
----------------------------------------------
V
------------------------------
I
------
Y
------------------------------------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------
D
S
-----
P
-
S
K
L
P
---------------------
A
----------------------------------
V
------------------------------------------------------------------------------
N
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
--
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
D
---
M
V
--
R
V
D
V
-------
L
I
N
G
E
R
V
D
A
--
L
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
---
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
--
G
-
T
H
--
I
I
---
A
R
S
T
------------
V
K
Q
L
--------------------------------------------------------------------------
1
PsiBlast_PDB
94.50
71%
-102
* C1 *
-
3DEG
-
LEPA_ECOLI
C:
[1-545]
---------
M
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
Q
I
C
G
G
L
S
D
-
R
--
E
--------
M
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
K
A
Q
S
V
T
L
D
Y
-----------
K
A
S
--
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
----
P
-----------
E
R
-------
V
-------
A
E
E
----
I
--------------------
E
D
---------------------------------------------------
I
--------------------------------------------------------
V
----------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------
I
----------------
D
--
A
--
T
D
A
----------------------------------
V
R
C
--
S
A
K
-------------------------------------------------------------------------------------------------------------
T
G
----------------------------------------------------------------------------------------------
V
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
D
------------
V
L
E
R
L
V
R
D
I
P
P
P
------
E
------------------
G
---------------------------
D
------------------------------------
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
--------------------------------------------------------------------------------
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
-
K
V
M
S
T
G
---------------------------
Q
------------------
T
Y
---
N
A
D
R
L
G
I
F
T
P
-
K
Q
-
V
D
R
-
T
E
L
K
C
G
E
V
G
W
L
V
C
A
I
K
D
I
H
G
A
P
V
G
D
T
L
T
L
A
R
N
-
P
-
A
----
E
K
A
L
P
G
-
F
-
K
-
K
-
V
K
P
Q
---
V
Y
A
-
G
L
F
P
V
S
S
D
-------
D
--
Y
E
---
A
F
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A
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G
K
L
S
---
L
N
D
A
S
L
F
Y
-
E
--
P
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S
S
S
A
L
G
F
G
F
R
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G
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L
G
L
L
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I
I
Q
E
R
L
E
R
E
Y
D
-
L
D
L
I
T
-----
T
A
P
T
V
V
Y
E
V
E
T
T
S
R
--------------
E
----------------------------------------------
V
------------------------------
I
------
Y
------------------------------------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------
D
S
-----
P
-
S
K
L
P
---------------------
A
----------------------------------
V
------------------------------------------------------------------------------
N
N
I
Y
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
--
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
D
---
M
V
--
R
V
D
V
-------
L
I
N
G
E
R
V
D
A
--
L
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
---
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
--
G
-
T
H
--
I
I
---
A
R
S
T
------------
V
K
Q
L
--------------------------------------------------------------------------
67
HHSearch
63.38
30%
-7
- C1 -
-
2BM0
1
?
A:
[4-689]
----
K
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
-
I
--
A
-------------------------
T
I
T
A
A
V
T
T
C
F
W
-----------
K
-------
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-----------
W
L
-------
V
-------
I
R
T
----
M
--------------------
Q
E
---------------------------------------------------
R
--------------------------------------------------------
L
GARPVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GNDLGTDIREIPIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
GEEPT
E
E
E
L
V
A
A
I
R
K
G
T
I
D
-----------------------------------------------------------------------------------------------
L
----------------
K
--
I
--
T
P
V
----------------------------------
F
L
G
--
S
A
L
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
L
L
D
A
V
V
D
Y
L
P
S
P
------
L
------------------
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
I
H
P---------
D
------------------------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--------------------------------------------------------------------------------
D
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
-
Y
N
T
T
K
G
---------------------------
R
------------------
K
E
---
R
V
A
R
L
L
R
M
H
A
N
H
R
-
E
E
V
-
E
E
L
K
A
G
D
L
G
A
V
V
-
G
L
K
---
E
T
I
T
G
D
T
L
V
G
E
D
A
---
P
----
R
V
I
L
E
S
-
I
-
E
-
V
-
P
E
P
V
---
I
D
V
-
A
I
E
P
K
T
K
A
-------
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
F
R
V
-
S
--
T
H
P
E
--
T
G
Q
-
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
-
V
D
A
N
V
-----
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
--------------
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
-------------------------------
Y
------------------------------
G
------
H
V
K
I
K
--------------------------------------------------------------
V
E
P
L
PRGS
G
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
Q--------------------------------------------------------------------------------------
S
G
-----
P
L
I
G
F
P
---------------------
V
VD
I
K
V
T
L
Y
D
G
S
Y
H
EVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
------------------------------------------------------------------------------
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
--
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
---
K
Q
--
V
Q
E
K
-------
L
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
62.35
27%
-24
- C1 -
-
2XEX
-
EFG_STAAU
B:
[4-680]
------
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
-
I
--
G
---------
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
-----------
E
-------
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
----
F
-----------
E
Y
-------
S
-------
V
S
T
L
H
D
R
L
QANAAPI
Q
L
P
I
G
AEDEFEAI
I
D
LVEM
K
C
F
K
Y
TNDLGTE
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
DEEIS
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
----------------------------------------------------------------------------
V
----------------
E
--
F
--
Y
P
V
----------------------------------
L
C
G
--
T
A
F
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
M
L
D
A
V
I
D
Y
L
P
S
P
------
L
------------------
D
VK
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
A-------
D
------------------------------------
D
S
A
E
F
A
A
L
A
F
K
V
M
T
--------------------------------------------------------------------------------
D
P
Y
-
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
-
K
N
S
T
K
G
---------------------------
K
------------------
R
E
---
R
V
G
R
L
L
Q
M
H
A
N
S
R
-
Q
E
I
-
D
T
V
Y
S
G
D
I
A
A
A
V
-
G
L
---
K
D
T
G
T
G
D
T
L
C
G
E
K
N
--------
D
I
I
L
E
S
-
M
-
E
-
F
-
P
E
P
V
---
I
H
L
-
S
V
E
P
K
S
K
A
-------
D
--
Q
D
---
K
M
T
Q
A
L
V
K
L
Q
---
E
E
D
P
T
F
H
A
-
H
--
T
-------
Q
-
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F
N
-
V
E
C
N
V
-----
G
A
P
M
V
S
Y
R
E
T
F
K
S
S
--------------
A
----------------------------------------------
Q
V
Q
G
K
F
S
R
Q
SGG
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
TGA
G
F
------
E
------------------------------------------------------------------
F
E
N
AIVGGVVPREY
I
P
S
V
E
A
G
L
K
D
A
M
E
-------------------------------------------------------------------------------------------------
N
G
-----
V
L
A
G
Y
P
---------------------
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DV-------------------
D
SS
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
-----------------------------------------------------------
K
C
D
P
V
I
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
-
R
V
D
G
M
E
P
R
G
--
N
A
Q
V
V
N
A
Y
V
P
L
S
E
M
-
F
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
--
Y
A
E
V
P
---
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
60.41
29%
-
- C1 -
-
1ZN0
-
EFG_THET8
B:
[7-681]
-------
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
------------------------------------
V
T
T
C
F
W
------------------
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-----------
W
L
-------
V
-------
I
R
T
----
M
--------------------
Q
E
---------------------------------------------------
R
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
ARPVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GNDLGT
D
I
R
E
I
P
IPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
-
L
----------------
K
--
I
--
T
P
V
----------------------------------
F
L
G
--
S
A
L
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
L
L
D
A
V
V
D
Y
L
P
S
P
------
L
------------------
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
IHP---------
D
------------------------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--------------------------------------------------------------------------------
D
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
-
Y
N
T
T
K
G
---------------------------
R
------------------
K
E
---
R
V
A
R
L
L
R
M
H
A
N
H
R
-
E
E
V
-
E
E
L
K
A
G
D
L
G
A
V
V
-
G
L
---
K
E
T
I
T
G
D
T
L
V
G
E
D
A
---
P
----
R
V
I
L
E
S
-
I
-
E
-
V
-
P
E
P
V
---
I
D
V
-
A
I
E
P
K
T
K
A
-------
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
F
R
V
-
S
--
T
H
P
-
E
-
T
G
Q
-
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
-
V
D
A
N
V
-----
G
K
P
Q
V
A
Y
R
E
T
I
T
K
P
--------------
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
-------------------------------
Y
------------------------------
G
------
H
V
K
I
K
--------------------------------------------------------------
V
E
P
L
P
RGSG
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
Q--------------------------------------------------------------------------------------
S
G
-----
P
L
I
G
F
P
---------------------
V
V
D
I
K
V
T
LY
D
G
S
Y
A
EV-------------------
D
SS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
-----------------------------------------------------------
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
--
N
A
Q
V
I
R
A
F
V
P
L
A
E
M
-
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
---
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Fugue
54.51
26%
-4
- C1 -
-
4M1K
1
?
A:
[6-688]
------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
----------------------------------
R
I
A
A
V
T
T
C
F
W
-------------------
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-----------
W
L
-------
V
-------
I
R
T
----
M
--------------------
Q
E
---------------------------------------------------
R
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
ARPVVM
Q
L
P
I
G
REDTFS
G
I
I
D
VLRM
K
A
Y
T
Y
GNDLGTDIREIPIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
---
I
----------------
D
--
L
--
K
I
T
----------------------------------
P
V
F
L
G
S
A
L
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
L
L
D
A
V
V
D
Y
L
P
S
P
LD
I
P
P
I
K
------------------
G
T
T
PEG
E
V
V
E
I
H
P---------------
D
------------------------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--------------------------------------------------------------------------------
D
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
-
Y
N
T
T
K
G
---------------------------
R
------------------
K
E
---
R
V
A
R
L
L
R
M
H
A
-
N
H
-
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
V
-
G
L
K
E
---
T
I
T
G
D
T
L
V
G
E
D
A
-
P
-
R
----
V
I
-
L
E
S
-
I
-
E
-
V
-
P
E
P
V
---
I
D
V
-
A
I
E
P
K
T
K
A
-------
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
F
R
V
-
S
TH
P
E
T
G
Q
T
I
I
S
G
-----
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
K
-
V
D
A
N
V
-----
G
K
P
Q
V
A
Y
R
E
T
I
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
D
V
---------------------
E
----------------------------------
G
------------------------------------------------------------------------------
K
F
I
R
L
T
G
G
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
-------
G
S
G
-
F
E
F
V
N
A
I
V
G
--
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
--
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
--
Y
D
G
S
Y
---
H
-----
E
V
-------
D
S
S
E
M
A
F
K
I
--
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
-
G
Q
--
I
L
G
M
E
P
R
G
N
------------
A
Q
V
I
R
A
-----------
F
V
P
L
A
E
-----
M
F
---
G
Y
A
-
T
D
L
R
S
K
T
-----
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
----
65
HHSearch
54.37
29%
-15
- C1 -
-
4ZCI
2
TYPA_ECOLI
B:
[35-628]
--------
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------
N
D
-------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-----------
D
W
-------
V
-------
V
D
Q
----
V
--------------------
F
D
---------------------------------------------------
L
--------------------------------------------------------
F
VNL-------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------------------------
A
TDEQ------------
L
--
D
--
F
P
I
----------------------------------
V
Y
A
--
S
A
L
-------------------------------------------------------------------------------------------------------------
N
G
----------------------------------------------------------------------------------------------
I
AGLDHEDMAE
D
--------------------------------------------------------------------------------------------------------------
M
T
P
------------
L
Y
Q
A
I
V
D
H
V
P
A
P
------
D
------------------
V
---------------------------
D
------------------------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--------------------------------------------------------------------------------
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
-
T
I
I
D
S
E
GKT------------------------
R
------------------
N
A
---
K
V
G
K
V
L
G
H
L
G
L
E
R
-
I
E
T
-
D
L
A
E
A
G
D
I
V
A
I
T
-
G
L
G
---
E
L
N
I
S
D
T
V
C
D
T
Q
N
--------
V
E
A
L
P
A
-
L
-
S
-
V
-
D
E
P
T
VSM
F
F
C
V
N
T
S
P
F
C
G
K
-------
E
GK
F
V
TSR
Q
I
L
D
R
L
N
K
E
L
---
V
H
N
V
A
L
R
V
-
E
--
E
T
-
E
--
D
A
D
A
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
-
G
-
F
E
L
A
V
-----
S
R
P
K
V
I
F
R
E
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
K
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K-
G
R
V
R
L
D
Y
V
I
P
S
R
G
L
-
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
PGE
V
G
QR
Q
N
G
V
-------
L
I
S
------------------
N
G
Q
G
K
A
V
A
F
---
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
--
Y
E
G
Q
--
I
I
---
G
-
I
H
SRSNDLTVNCLT------VLVPPIRMTLE
Q
A
-
L
E
F
IDDDE
L
V
EVT
P
T
S
I
R
I
R
K
R
-
H
L
T
E
-------------------------------
68
HHSearch
53.81
27%
8
- C1 -
-
3J0E
-
EFG_ECOLI
H:
[4-691]
-------
T
P
I
A
R
Y
R
N
I
G
I
S
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
V
N
H
K
-
I
--
G
EVH-----
D
G
A
A
T
M
D
W
M
E
Q
E
Q
E
R
G
I
T
I
T
S
A
A
T
T
A
F
W
-----------
S
G
M
AK
Q
Y
E
P
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
V
M
V
Y
C
A
V
G
G
V
Q
P
Q
S
E
T
V
W
R
Q
A
N
K
Y
K
V
P
R
I
A
F
V
N
K
M
D
R
M
G
A
N
----
F
-----------
L
K
-------
V
-------
V
N
Q
----
I
--------------------
K
T
---------------------------------------------------
R
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
ANPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLN
N
----------------
E
--
I
--
I
L
V
----------------------------------
T
C
G
--
S
A
F
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
A
------------
M
L
D
A
V
I
D
Y
L
P
S
P
------
V
------------------
D
---------------------------
V
PAINGILDDGKDTPAERHAS----------------
D
D
E
P
F
S
A
L
A
F
K
I
A
T
--------------------------------------------------------------------------------
D
P
F
-
V
G
N
L
T
F
F
R
V
Y
S
G
V
V
N
S
G
D
T
V
-
L
N
S
V
K
A
---------------------------
A
------------------
R
E
---
R
F
G
R
I
V
Q
M
H
A
N
K
R
-
E
E
I
-
K
E
V
R
A
G
D
I
A
A
A
I
-
G
L
K
---
D
V
T
T
G
D
T
L
C
D
P
D
A
--------
P
I
I
L
E
R
-
M
-
E
-
F
-
P
E
P
V
---
I
S
I
-
A
V
E
P
K
T
K
A
-------
D
--
Q
E
---
K
M
G
L
A
L
G
R
L
A
---
K
E
D
P
S
F
R
V
-
W
--
T
D
E
E
--
S
N
Q
-
T
I
I
A
G
M
G
E
L
H
L
D
I
I
V
D
R
M
K
R
E
F
N
-
V
E
A
N
V
-----
G
K
P
Q
V
A
Y
R
E
T
I
R
Q
K
VTDVEGKHAKQSGG
R
GQYG------------------------------------------
H
------------------------------
V
------
V
ID----------------------------------------------------------------
M
YPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLK-----------------------------------------------------------------------------------
A
G
-----
P
L
A
G
Y
P
---------------------
V
VDMGIRLHFGSYHDV-------------------
D
SSELAFKLAASIAFKEGFK-----------------------------------------------------------
K
A
K
P
V
L
L
E
P
I
M
K
V
E
V
E
T
P
E
E
N
T
G
D
V
I
G
D
L
S
R
R
R
G
-
M
L
K
G
Q
E
S
E
V
--
T
G
V
K
I
H
A
E
V
P
L
S
E
M
-
F
G
Y
A
T
Q
L
R
S
L
T
K
G
R
A
S
Y
T
M
E
F
L
K
--
Y
D
E
A
P
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
53.18
28%
-32
- C1 -
-
4ZCL
2
TYPA_ECOLI
A:
[36-523]
---------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-----------
D
W
-------
V
-------
V
D
Q
----
V
--------------------
F
D
---------------------------------------------------
L
F-------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------------------------
L
----------------
D
--
A
--
T
D
E
Q
L
DF------------------------------
P
I
V
--
Y
A
S
-------------------------------------------------------------------------------------------------------------
A
L
----------------------------------------------------------------------------------------------
N
----------
G
--------------------------------------------------------------------------------------------------------------
I
A
G
LDHEDMAEDM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------
D
------------------
V
---------------------------
D
------------------------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--------------------------------------------------------------------------------
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
---------------------------
K
------------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
-
E
R
-
I
E
T
-
D
L
A
E
A
G
D
I
-
V
A
I
T
G
L
G
E
L
---
N
I
S
D
T
V
--
C
D
T
-
Q
-
N
----
V
E
A
L
P
A
-
L
-
S
-
V
-
D
E
P
T
---
V
-
S
-
M
F
F
C
V
N
T
S
PFCGKEG
K
--
F
V
---
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
--
T
E
D
A
D
A
----
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
-
G
-
F
E
L
A
V
-----
S
R
P
K
V
I
F
R
E
I
D
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K-
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
53.08
28%
-30
- C1 -
-
4ZCI
1
TYPA_ECOLI
A:
[36-523]
---------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-----------
D
W
-------
V
-------
V
D
Q
----
V
--------------------
F
D
---------------------------------------------------
L
F-------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------------------------
L
----------------
D
--
A
--
T
D
E
QLDF------------------------------
P
I
V
--
Y
A
S
-------------------------------------------------------------------------------------------------------------
A
L
----------------------------------------------------------------------------------------------
N
----------
G
--------------------------------------------------------------------------------------------------------------
I
A
G
LDHEDMAEDM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------
D
------------------
V
---------------------------
D
------------------------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--------------------------------------------------------------------------------
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
---------------------------
K
------------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
-
E
R
-
I
E
T
-
D
L
A
E
A
G
D
I
-
V
A
I
T
G
L
G
E
L
---
N
I
S
D
T
V
--
C
D
T
-
Q
-
N
----
V
E
A
L
P
A
-
L
-
S
-
V
-
D
E
P
T
---
V
-
S
-
M
F
F
C
V
N
T
S
PFCGKEG
K
--
F
V
---
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
--
T
E
D
A
D
A
----
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
-
G
-
F
E
L
A
V
-----
S
R
P
K
V
I
F
R
E
I
D
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K-
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
51.98
32%
-60
- C1 -
-
5VH6
-
EFG_BACSU
A:
[6-403]
-----
R
E
F
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
F
Y
T
G
R
I
---------------------------------
I
T
S
A
A
T
T
A
Q
W
-----------
K
-------
G
Y
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
A
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
I
G
A
D
----
F
-----------
L
Y
-------
S
V
G
T
L
---
R
D
R
----
L
--------------------
Q
A
NAHAIQLPIGAEDNFEGIID-------------------------------
L
VEN
V
A
Y
F
Y
EDDLGTRSDAKEIPEEY
K
E
Q
A
E
E
L
R
N
S
L
I
E
A
V
C
E
L
D
E
E
L
M
D
K
Y
L
E
G
E
E
I
----------------------------------------------------------------------------------------------
T
-----------------------------------------------------------------------------------------------
I
D
E
L
K
A
G
I
R
K
G
T
L
N
V--
E
--
F
--
Y
P
V
----------------------------------
L
V
G
--
S
A
F
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
V
L
D
A
V
L
D
Y
L
P
A
P
------
T
------------------
D
VAA
I
K
G
T
R
P
DTN
E
E
I
E
R
H
S--------
S
------------------------------------
D
E
E
P
F
S
A
L
A
F
K
V
M
T
--------------------------------------------------------------------------------
D
P
Y
-
V
G
K
L
T
F
F
R
V
Y
S
G
T
L
D
S
G
S
Y
V
-
K
N
S
T
K
G
---------------------------
K
------------------
R
E
---
R
V
G
R
I
L
Q
M
H
A
N
S
R
-
E
E
I
-
S
T
V
Y
A
G
D
I
A
A
A
V
-
G
L
---
K
D
T
T
T
G
D
T
L
C
D
E
K
D
--------
L
V
I
L
E
S
-
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
51.50
24%
-35
- C1 -
-
5ANB
-
EFL1_HUMAN
K:
[14-1115]
-------
K
N
T
A
N
I
R
N
I
C
V
L
A
H
V
D
H
G
K
T
T
L
A
D
C
L
I
S
S
N
G
I
I
S
S
-
R
--
L
A
-------
G
K
L
R
Y
M
D
S
R
E
D
E
Q
I
R
G
I
T
M
K
S
S
A
I
S
L
H
Y
-----------
A
T
---
G
N
E
E
Y
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
S
T
A
V
R
I
C
D
G
C
I
I
V
V
D
A
V
E
G
V
C
P
Q
T
Q
A
V
L
R
Q
A
W
L
E
N
I
R
P
V
L
V
I
N
K
I
D
R
L
I
V
E
----
L
KFT
P
-------
Q
E
A
Y
S
H
L
K
N
I
-------
L
E
Q
----
I
--------------------
N
A
L
T
G
T
LFTS
K
V
L
E
E
R
A
E
RETESQVN
P
N
S
E
Q
G
E
Q
V
Y
DWSTGLEDTDDS-----
H
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Y
-----------------------------------------------------------------------------------------------
F
----------------
S
PE
Q
--
G
N
V
----------------------------------
V
F
T
--
S
A
I
DG
W
G
F
G
I
E
H
F
A
R
I
Y
S
Q
K
IGIK
K
E
V
L
M
K
TLW
G
D
Y
Y
I
NMKAKKIMKGDQAKGKKPLFVQL
I
L
E
N
I
W
S
L
Y
D
A
V
L
K
KDK
D
K
I
D
K
I
V
T
S
LGLKIGAREARHSDPK
V
Q
I
N
A
I
C
SQ
W
L
----------------------------------------------------------------------------------------------
P
----------
I
--------------------------------------------------------------------------------------------------------------
S
H
A
------------
V
L
A
M
V
C
Q
K
L
P
S
P
------
L
------------------
D
---------------------------
I
TAERVERLMCTGSQTFDSFPPETQ
A
L
K
A
A
F
M
K
CGSE
D
T
A
P
V
I
I
F
V
S
K
M
F
A
VDAKALPQNKPRPLTQEE
I
A
Q
R
R
E
R
A
R
QRHAE
K
L
A
A
A
Q
GQAPLEPTQDGSAIETCPKGEEPRGDEQQVESMTPKPVLQ
E
E
N
N
Q
-
E
S
F
I
A
F
A
R
V
F
S
G
V
A
R
R
G
K
K
I
-
F
V
L
G
P
K
Y
S
P
L
E
F
L
RRVPLGFSAPPDGL
P
Q
V
P
H
M
A
------------------
Y
C
---
A
L
E
N
L
Y
L
L
M
G
R
E
L
-
E
Y
L
-
E
E
V
P
P
G
N
V
L
G
I
G
-
G
L
Q
D
--
F
V
L
K
S
A
T
L
C
S
L
P
S
--------
C
P
P
F
I
P
L
N
-
F
-
E
-
A
T
P
I
---
V
R
V
-
A
V
E
P
K
H
P
S
-------
E
--
M
P
---
Q
L
V
K
G
M
K
L
L
N
---
Q
A
D
P
C
V
Q
I
-
L
--
I
Q
E
---
T
G
E
-
H
V
L
V
T
A
G
E
V
H
L
Q
R
C
L
D
D
L
K
E
R
F
A
K
I
H
I
S
V
-----
S
E
P
I
I
P
F
R
E
T
I
T
K
P
P-------------
K
VDMVNEEIGKQQKVAVIHQMKEDQSKIPEGIQVDSDGLI
T
I
T
T
PNK
L
------------------------------
A
------
T
L
S
V
R
--------------------------------------------------------------
A
M
P
LP
E
E
V
T
Q
I
L
E
E
NSDLIRSMEQLTSSLNEGE
N
T
H
M
I
H
Q
K
T
QEKIWEFKGK
L
E
Q
H
L
T
GRR
W
R
N
I
V
DQIWSFGPRKCGP
N
I
L
V
N
KSEDFQNSVWTGPADKASKEASRYRDLG
N
S
I
V
S
G
F
Q
L
A
T
L
S
G
-----
P
M
C
E
E
P
---------------------
L
M
G
V
C
F
V
L
E--------------------------
K
WDLSKFEEQGA
S
D
L
A
K
E
G
Q
E
E
N
E
T
C
S
GGNENQELQDGCS
E
A
F
E
K
RTSQKGESPLTDCYGPF
S
G
Q
L
I
A
T
M
K
E
A
C
R
Y
A
L
Q
V
K
P
Q
R
L
M
A
A
M
Y
T
C
D
I
M
A
T
G
D
V
L
G
R
V
Y
A
V
L
S
K
R
E
G
-
R
V
L
Q
E
E
M
K
E
GT
D
M
F
I
I
K
A
V
L
P
V
A
E
S
-
F
G
F
A
D
E
I
R
K
R
T
S
G
L
A
S
P
Q
L
V
F
S
H
--
W
E
I
I
P
---
S
D
--
P
F
W
V
PTT
E
E
E
Y
L
H
F
G
E
K
A
D
S
EN
Q
A
R
K
Y
M
N
A
V
R
K
R
K
G
L
Y
V
E
E
---
K
I
V
E
H
A
E
K
Q
R
T
-------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
51.16
28%
-30
- C1 -
-
4ZCM
2
TYPA_ECOLI
A:
[36-523]
---------
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
----------------------------------
T
I
L
A
K
N
T
A
I
K
W
-----------
N
-------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
----
P
-----------
D
W
-------
V
-------
V
D
Q
----
V
--------------------
F
D
---------------------------------------------------
L
F-------------------------------------------------------
V
----------------------------------------------------------------------------------------------
N
-----------------------------------------------------------------------------------------------
L
----------------
D
--
A
--
T
D
E
QLDF------------------------------
P
I
V
--
Y
A
S
-------------------------------------------------------------------------------------------------------------
A
L
----------------------------------------------------------------------------------------------
N
----------
G
--------------------------------------------------------------------------------------------------------------
I
A
G
LDHEDMAEDM
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
------
D
------------------
V
---------------------------
D
------------------------------------
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
--------------------------------------------------------------------------------
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
---------------------------
K
------------------
T
R
N
A
K
V
G
K
V
L
G
H
L
G
L
-
E
R
-
I
E
T
-
D
L
A
E
A
G
D
I
-
V
A
I
T
G
L
G
E
L
---
N
I
S
D
T
V
--
C
D
T
-
Q
-
N
----
V
E
A
L
P
A
-
L
-
S
-
V
-
D
E
P
T
---
V
-
S
-
M
F
F
C
V
N
T
S
PFCGKEG
K
--
F
V
---
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
--
T
E
D
A
D
A
----
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
-
G
-
F
E
L
A
V
-----
S
R
P
K
V
I
F
R
E
I
D
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
K-
G
R
V
R
L
D
Y
V
I
P
-
S
R
G
L
I
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
50.28
24%
4
- C1 -
-
5MQF
-
U5S1_HUMAN
B:
[124-909]
-------
D
N
S
E
L
I
R
N
V
T
L
C
G
H
L
H
H
G
K
T
C
F
V
D
C
L
I
E
Q
T
H
P
E
I
R
-
K
RY
D
--------
Q
D
L
C
Y
T
D
I
L
F
T
E
Q
E
R
G
V
G
I
K
S
T
P
V
T
V
V
L
-----------
P
D
T
--
K
G
K
S
Y
L
F
N
I
M
D
T
P
G
H
V
N
F
S
D
E
V
T
A
G
L
R
I
S
D
G
V
V
L
F
I
D
A
A
E
G
V
M
L
N
T
E
R
L
I
K
H
A
V
Q
E
R
L
A
V
T
V
C
I
N
K
I
D
R
L
I
L
E
----
L
KLP
P
T
D
A
Y
Y
K
L
R
H
-------
I
-------
V
D
E
----
V
--------------------
N
G
---------------------------------------------------
L
--------------------------------------------------------
I
----------------------------------------------------------------------------------------------
S
M
Y
STDENLI--------------------------------------------------------------------------------------
L
----------------
S
--
P
LL
G
N
V
----------------------------------
C
F
S
--
S
S
Q
-------------------------------------------------------------------------------------------------------------
Y
S
I
C
F
T
L
G
S
F
A
K
I
Y
A
D
T
FGDINY
Q
E
F
A
K
R
LWG
D
I
Y
F
N
PKT
R
K
F
T
KKAPTSSSQRSFVEFI
L
E
P
L
Y
K
I
L
A
Q
V
VGDVDTS
L
P
R
T
L
D
E
L
G
I
H
L
T
K
E
E
L
K
L
----------
N
I
R
P
L
L
R
L
V
C
K
K
FFGE-----------------------------------------------------------------------------------------------
F
T
G
------------
F
V
D
M
C
V
Q
H
I
P
S
P
------
K
------------------
V
G
A
K
P
K
I
E
H
T
YTGGVDS
D
L
G
E
A
M
S
D
C
--
D
------------------------------------
P
D
G
P
L
M
C
H
T
T
K
M
Y
S
T
-------------------------------------------------------------------------------
D
D
G
-
V
Q
F
H
A
F
G
R
V
L
S
G
T
I
H
A
G
Q
P
V
-
K
V
L
G
E
N
YTLEDEED
S
------------------
Q
------------------
I
C
---
T
V
G
R
L
W
I
S
V
A
R
Y
H
-
I
E
V
-
N
R
V
P
A
G
N
W
V
L
I
E
-
G
V
D
Q
--
P
I
V
K
T
A
T
I
T
E
P
R
G
-
N
E
E
----
A
Q
I
F
R
P
-
L
-
K
-
F
N
T
T
S
V
---
I
K
I
-
A
V
E
P
V
N
P
S
-------
E
--
L
P
---
K
M
L
D
G
L
R
K
V
N
---
K
S
Y
P
S
L
T
T
-
K
--
V
E
E
S
---
G
E
-
H
V
I
L
G
T
G
E
L
Y
L
D
C
V
M
H
D
L
R
K
M
Y
S
E
I
D
I
K
V
-----
A
D
P
V
V
T
F
C
E
T
V
V
E
T
--------------
S
----------------------------------------------
S
L
K
C
F
A
E
T
PNK
K
N
K
I
T
---------------
M
------
I
------------------------------------------------------------------
A
E
P
L
E
K
G
L
A
E
D
I
E
N
EVVQITWN
R
K
K
L
G
E
F
F
Q
T
K
YDWD
L
L
A
A
R
S
IWAFGPDATGP
N
I
L
V
D
D
T
L
P
S
E
V
D
K
A
L
L
G
S
V
K
D
S
I
V
Q
G
F
Q
W
G
T
R
-------------------------------------
E
G
-----
P
L
C
D
E
L
---------------------
I
RN
V
K
F
K
I
L
D
A
V
V
A
QEPLHRG--------------
G
GQI
I
P
T
A
R
R
V
V
Y
S
A
F
L
--------------------------------------------------------------
M
A
T
P
R
L
M
E
P
Y
Y
F
V
E
V
Q
A
P
A
D
C
V
S
A
V
Y
T
V
L
A
R
R
R
G
-
H
V
T
Q
D
A
P
I
P
GS
P
L
Y
T
I
K
A
F
I
P
A
I
D
S
-
F
G
F
E
T
D
L
R
T
H
T
Q
G
Q
A
F
S
L
S
V
F
H
H
--
W
Q
I
V
P
---
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
50.10
22%
-4
- C1 -
-
3JB9
-
SN114_SCHPO
B:
[136-923]
-------
T
G
T
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
Y
Y
T
H
P
D
T
K
-
P
--
P
KR------
R
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
K
S
T
P
L
T
L
A
V
-----------
S
D
M
--
K
G
K
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
V
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
M
P
I
V
L
V
L
N
K
V
D
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
----
R
H
-------
V
-------
I
D
E
----
V
--------------------
N
D
---------------------------------------------------
N
--------------------------------------------------------
I
----------------------------------------------------------------------------------------------
C
Q
I
SKDLK
Y
R
--------------------------------------------------------------------------------------
V
----------------
S
PE
L
--
G
N
V
----------------------------------
C
F
A
--
S
C
D
-------------------------------------------------------------------------------------------------------------
L
G
----------------------------------------------------------------------------------------------
Y
----------
C
F
T
L
S
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
LWGD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
F
QIYLK
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
S
F
FGF-
P
V
G
------------
F
V
N
A
V
T
R
H
I
P
S
P
------
R
------------------
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
------------------------------------
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
--------------------------------------------------------------------------------
T
V
D
A
N
N
F
Y
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
-
K
V
L
G
E
N
---------------------------
Y
SLEDEED
M
V
---------
V
A
---
H
I
A
E
I
C
V
P
C
A
R
Y
R
-
L
H
V
-
D
G
A
V
A
G
M
L
V
L
L
G
-
G
V
D
N
S
--
I
S
K
T
A
T
I
V
S
D
N
L
K
D
-
D
----
P
Y
I
F
R
P
-
I
A
H
-
M
-
S
E
S
V
---
F
K
V
-
A
V
E
P
H
N
P
S
-------
E
--
L
P
---
K
L
L
D
G
L
R
K
T
N
---
K
S
Y
P
L
S
I
T
-
K
--
V
E
E
S
---
G
E
-
H
T
I
F
G
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
Y
S
E
I
E
I
R
V
-----
S
D
P
V
A
R
F
C
E
T
A
V
D
T
--------------
S
----------------------------------------------
S
I
K
C
F
S
D
T
PNKK-------------------
N
R
I
T
M
--
V
------------------------------------------------------------------
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDRGT
N
I
L
R
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
Q
G
F
Q
W
G
T
R-------------------------------------
E
G
-----
P
L
C
D
E
T
---------------------
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRG--------------
G
GQI
I
P
T
A
R
R
V
C
Y
S
S
F
L
--------------------------------------------------------------
T
A
S
P
R
L
M
E
P
V
Y
M
V
E
V
H
A
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
-
H
V
L
Q
D
I
P
R
P
GS
P
L
Y
L
V
R
A
L
I
P
V
I
D
S
-
C
G
F
E
T
D
L
R
V
H
T
Q
G
Q
A
M
C
Q
M
V
F
D
H
--
W
Q
V
V
P
---
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
49.13
22%
-4
- C1 -
-
5LJ3
-
SN114_YEAST
C:
[129-941]
--------
I
P
E
R
I
I
N
V
G
V
I
G
P
L
H
S
G
K
T
S
L
M
D
L
L
V
I
D
S
H
K
R
I
P
-
D
--
M
SKNVELGW
K
P
L
R
Y
L
D
N
L
K
Q
E
I
D
R
G
L
S
I
K
L
N
G
S
T
L
L
C
-----------
T
D
L
--
E
S
K
S
R
M
I
N
F
L
D
A
P
G
H
V
N
F
M
D
E
T
A
V
A
L
A
A
S
D
L
V
L
I
V
I
D
V
V
E
G
V
T
F
V
V
E
Q
L
I
K
Q
S
I
K
N
N
V
A
M
C
F
V
I
N
K
L
D
R
L
I
L
D
----
L
KLPP-------
M
D
-------
A
YLKLNHI
I
A
N
----
I
--------------------
N
S
---------------------------------------------------
F
--------------------------------------------------------
T
KGN-------------------------------------------------------------------------------------------
V
-----------------------------------------------------------------------------------------------
F
----------------
S
PI
D
--
N
N
I
----------------------------------
I
F
A
--
S
T
K
-------------------------------------------------------------------------------------------------------------
L
G
----------------------------------------------------------------------------------------------
F
----------
T
FTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQPFLKHVLQLIFRQ
Q
T
G
------------
L
V
D
A
I
T
R
C
Y
Q
-
P
------
F
------------------
E
LFDNKTAHLSIPGKS------------
T
------------------------------------
P
E
G
T
L
W
A
H
V
L
K
T
V
D
--------------------------------------------------------------------------------
Y
-
G
-
G
A
E
W
S
L
V
R
I
Y
S
G
L
L
K
R
G
D
T
V
-
R
I
L
D
T
S
---------------------------
Q
SESRQKRQLHDIEDDETP
S
C
---
E
V
E
E
I
G
L
L
G
G
R
Y
V
-
Y
P
V
-
H
E
A
H
K
G
Q
I
V
L
I
K
-
G
I
S
S
--
A
Y
I
K
S
A
T
L
Y
S
V
K
S
-
K
-
E
DMKQ
L
K
F
F
K
P
-
L
-
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Y
I
-
T
E
A
V
---
F
K
I
-
V
L
Q
P
L
L
P
R
-------
E
--
L
P
---
K
L
L
D
A
L
N
K
I
S
---
K
Y
Y
P
G
V
I
I
-
K
--
V
E
E
S
---
G
E
-
H
V
I
L
G
N
G
E
L
Y
M
D
C
L
L
Y
D
L
R
A
S
Y
A
K
I
E
I
K
I
-----
S
D
P
L
T
V
F
S
E
S
C
S
N
E
--------------
S
----------------------------------------------
F
------------------------------
A
SIPVSN-ISVAAEPMDSKMIQDLSRPRKLSKILRTEYGWDSLASRNVWSFYNLINDTLPDEISPELLSKYKEQ
I
IQGFYWAVK------------------------------------------------------------------------------------------------------------------
E
G
-----
P
L
A
E
E
P
IYGVQYKLLSISVPSDVNIDV
M
----------------------------------
K
SQIIPLMKKACYVGLL--------------------------------------------------------------
T
A
I
P
I
L
L
E
P
I
Y
E
V
D
I
T
V
H
A
P
L
L
P
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V
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L
M
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K
R
R
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K
T
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V
A
GT
P
L
L
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V
R
G
Q
V
P
V
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S
-
A
G
F
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T
D
L
R
L
S
T
N
G
L
G
M
C
Q
L
Y
F
W
H
KI
W
R
K
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
49.05
24%
3
- C1 -
-
2DY1
1
?
A:
[6-651]
---------
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
-
R
--
G
R
VE-----
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
-----------
R
-------
G
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
G
G
D
-----
Y
-----------
Y
A
-------
L
-------
L
E
D
----
L
--------------------
R
S
---------------------------------------------------
T
--------------------------------------------------------
L
GPILPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
--------------------
E
-----------------------------------------------------------------------------------------------
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
R
G
L
--
L
--
Y
P
V
----------------------------------
A
L
A
--
S
G
E
-------------------------------------------------------------------------------------------------------------
R
E
----------------------------------------------------------------------------------------------
I
----------
G
--------------------------------------------------------------------------------------------------------------
V
L
P
------------
L
L
E
L
I
L
E
A
L
P
S
P
------
T
------------------
E
R--------------------------
F
------------------------------------
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
--------------------------------------------------------------------------------
D
P
F
-
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
-
Q
S
E
A
-----------------------------
G
------------------
Q
V
---
R
L
P
H
L
Y
V
P
M
G
K
D
L
-
L
E
V
-
E
E
A
E
A
G
F
V
L
G
V
P
-
K
---
A
E
G
L
H
R
G
M
V
L
W
Q
G
E
K
-
P
-
E
----
S
E
E
V
P
F
-
A
-
R
-
L
-
P
D
P
N
---
V
P
V
-
A
L
H
P
K
G
R
T
-------
D
--
E
A
---
R
L
G
E
A
L
R
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L
---
E
E
D
P
S
L
K
L
-
E
--
R
Q
E
E
--
T
G
E
-
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
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R
L
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-
Y
G
-
V
E
V
E
F
-----
S
V
P
K
V
P
Y
R
E
T
I
K
K
V
--------------
A
E
G
Q
G
K
Y
K
K
Q
T
GG----------------------------------
H
G
Q
Y
G
D
V
W
-----------------------
L
------
R
------------------------------------------------------------------
L
E
P
A
S
E
Y
G
F
E
W
RITGGVIPSKY
Q
E
A
I
E
E
G
I
K
E
A
A
K-----------------------------------------------------------------------------------------
K
G
-----
V
L
A
G
F
P
---------------------
V
MG
F
K
A
I
VY
N
G
S
Y
H
EV-------------------
D
SS
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
-----------------------------------------------------------
E
A
H
P
V
L
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
-
R
I
L
G
M
E
Q
E
G
--
A
L
S
V
V
H
A
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P
L
A
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V
-
L
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Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
--
Y
A
E
V
P
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
48.87
25%
11
- C1 -
-
3VQT
1
RF3_DESVM
A:
[25-547]
------
E
R
E
A
A
R
R
R
T
F
A
I
I
S
H
P
D
A
G
K
T
T
L
T
E
K
L
L
L
F
G
G
A
I
Q
M
-
A
--
G
S
V
K
A
R---------------------
V
T
T
S
V
M
Q
F
P
Y
-----------
R
-------
D
R
V
V
N
L
L
D
T
P
G
H
Q
D
F
S
E
D
T
Y
R
V
L
T
A
V
D
S
A
L
V
V
I
D
A
A
K
G
V
E
A
Q
T
R
K
L
M
D
V
C
R
M
R
A
T
P
V
M
T
F
V
N
K
M
D
R
E
A
L
H
----
P
-----------
L
D
-------
V
-------
M
A
D
----
I
--------------------
E
Q
---------------------------------------------------
H
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
Q
I
E
C
A
P
M
T
W
P
I
G
MGSSFK
G
T
Y
D
LLHK
Q
L
H
L
F
SQ
S
G
I
V
I
H
G
ADDP
Q
L
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LGDQ
A
E
Q
L
R
M
D
L
A
L
L
E
E
A
G
T
P
FD
E
E
R
Y
L
K
------------------
G
----------------
E
--
L
--
T
P
V
----------------------------------
F
F
G
--
S
A
I
-------------------------------------------------------------------------------------------------------------
N
N
----------------------------------------------------------------------------------------------
F
----------
G
--------------------------------------------------------------------------------------------------------------
V
R
E
------------
M
L
D
M
F
V
E
F
A
P
G
P
------
Q
------------------
P
---------------------------
R
P
A
AT
R
V
V
E
P---------------------------
G
E
E
A
F
T
G
V
V
F
K
I
Q
A
--------------------------------------------------------------------------------
N
-----
R
M
A
F
L
R
I
C
S
G
T
F
T
R
G
M
R
L
-
K
H
H
R
T
G
---------------------------
K
------------------
D
V
---
T
V
A
N
A
T
I
F
M
A
Q
D
R
-
T
G
V
-
E
E
A
F
P
G
D
I
I
G
I
P
-
N
---
H
G
T
I
K
I
G
D
T
F
T
E
S
K
E
--------
V
L
K
F
V
G
-
I
-
P
-
N
-
F
A
P
E
---
H
F
R
-
R
V
R
L
K
N
P
L
-------
K
--
A
K
---
Q
L
Q
K
G
L
E
Q
L
A
---
E
E
G
A
V
Q
L
F
-
R
--
P
L
V
----
N
N
D
Y
I
L
G
A
V
G
V
L
Q
F
D
V
I
V
A
R
L
A
D
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Y
G
-
V
D
A
V
Y
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G
V
ST
H
T
A
R
W
V
Y
C
E
D
K
K
I
F
--------------
A
D
F
Q
D
Y
H
R
---------------------------------------
G
------------------------------
E
------
L
------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------
V
D
AEG
A
L
A
-
Y
L
A
P
---------------------
N
----------------------------------
P
------------------------------------------------------------------------------
W
R
L
E
S
A
M
E
R
Y
P
K
V
E
F
R
T
T
R
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Fugue
48.64
24%
-10
- C1 -
-
1ELO
-
?
?:
[5-689]
-----
V
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
-----------------------------------------
V
-----------
T
T
C
--
F
W
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
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V
E
R
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M
R
V
L
D
G
A
I
V
V
F
D
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S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-----------
W
L
-------
V
-------
I
R
T
----
M
--------------------
Q
E
---------------------------------------------------
R
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
A
R
P
V
V
M
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
YGNDLGT
D
I
R
E
I
PIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
-------------------------------------
V
----------------
E
--
V
--
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
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T
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E
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L
V
A
A
I
R
K
G
T
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D
LK
I
T
P
V
F
L
G
S
A
L
-------------------------------------------------------------------------------------------------------------
K
N
----------------------------------------------------------------------------------------------
K
----------
G
--------------------------------------------------------------------------------------------------------------
V
Q
L
------------
L
L
D
A
V
V
D
Y
L
P
S
P
------
L
D
I
P
P
I
K
G
T
T
P
E
G
E
V
V
E
I
H
P
---------------------------
D
------------------------------------
P
N
G
P
L
A
A
L
A
F
K
I
M
A
--------------------------------------------------------------------------------
D
P
Y
-
V
G
R
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I
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V
Y
S
G
T
L
T
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G
S
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-
Y
N
T
T
K
G
---------------------------
R
------------------
K
E
---
R
V
A
R
L
L
R
M
H
A
-
N
H
R
E
E
V
-
E
E
L
K
A
G
D
L
G
A
V
V
----
G
L
K
E
T
I
T
G
D
T
L
V
G
E
D
A
-
P
-
R
----
V
I
L
I
D
V
---------------------------------
A
--
I
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---
P
K
S
Q
A
L
A
R
L
A
---
E
E
D
P
T
-
F
R
-
V
--
S
T
H
P
Q
T
I
I
S
G
-----
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F
------
V
-----
G
K
P
Q
V
A
Y
R
E
T
I
T
K
--------------------------------------------------------------
P
------------------------------
V
------
D
------------------------------------------------------------------
V
---------------------------------------------------------------------------------------------------------------------------
E
G
-----
K
-
F
I
R
Q
---------------------
T
----------------------------------
G
------------------------------------------------------------------------------
G
-----
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
R
G
S
---------
G
-
F
E
F
V
N
A
I
V
G
--
G
V
I
P
K
E
Y
I
P
A
V
Q
K
G
I
E
E
A
M
Q
S
G
P
L
I
G
F
P
V
V
D
I
K
V
T
L
Y
D
--
G
S
Y
H
E
---
V
D
--
S
S
E
M
-------
A
F
K
I
A
G
S
M
A
--
I
K
E
A
V
Q
K
--
G
D
P
V
I
L
E
P
I
M
---
R
V
E
V
T
T
P
E
E
-
Y
M
G
D
V
I
G
D
L
--
N
-
A
R
RG
Q
I
---
L
G
M
E
------------
P
R
G
N
A
Q
-----------
V
I
-
R
A
F
-----
V
P
---
L
A
E
-
M
F
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
Y
Q
E
V
P
K
Q
V
Q
E
K
L
I
K
---
9
PsiBlast_PDB
35.20
36%
-101
- C1 -
-
4MYT
1
EFG_THETH
A:
[6-181]
------
E
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
-----------------------------------
A
A
V
T
T
C
F
W
------------------
K
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
----
L
-----------
W
L
-------
V
-------
I
R
T
----
M
--------------------
Q
E
---------------------------------------------------
R
--------------------------------------------------------
L
----------------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------------------------------
A
----------------------------------
R
P
V
--
V
M
Q
-------------------------------------------------------------------------------------------------------------
L
P
----------------------------------------------------------------------------------------------
I
----------
G
--------------------------------------------------------------------------------------------------------------
R
E
D
------------
T
F
S
G
I
I
D
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
29.37
38%
-44
- C1 -
-
2P8W
1
EF2_YEAST
T:
[16-169]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
----------------------------
G
I
T
I
K
S
T
A
I
S
L
Y
S
EMSDEDVKEIK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
29.27
38%
-44
- C1 -
-
2P8X
1
EF2_YEAST
T:
[16-167]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
----------------------------
G
I
T
I
K
S
T
A
I
S
L
Y
S
EMSDEDVKEIK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
29.20
38%
-44
- C1 -
-
1U2R
1
EF2_YEAST
A:
[16-162]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
----------------------------
G
I
T
I
K
S
T
A
I
S
L
Y
S
E
M
S
D
E
D
V
K
E
IK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
29.20
38%
-44
- C1 -
-
2P8Z
1
EF2_YEAST
T:
[16-167]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
----------------------------
G
I
T
I
K
S
T
A
I
S
L
Y
S
EMSDEDVKEIK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
29.17
38%
-44
- C1 -
-
2P8Y
1
EF2_YEAST
T:
[16-167]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
----------------------------
G
I
T
I
K
S
T
A
I
S
L
Y
S
EMSDEDVKEIK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
27.94
38%
-24
- C1 -
-
2E1R
1
EF2_YEAST
A:
[16-161]
---------
V
T
N
V
R
N
M
S
V
I
A
H
V
D
H
G
K
S
T
L
T
D
S
L
V
Q
R
A
G
I
I
S
A
A
K
------------------------
E
R
G
I
T
I
K
S
T
A
I
S
L
Y
S
E
M
S
D
E
D
V
K
E
IK
Q
K
T
--
D
G
N
S
F
L
I
N
L
I
D
S
P
G
H
V
D
F
S
S
E
V
T
A
A
L
R
V
T
D
G
A
L
V
V
V
D
T
I
E
G
V
C
V
Q
T
E
T
V
L
R
Q
A
L
G
E
R
I
K
P
V
V
V
I
N
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------