@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUP1: (2017-12-19 )
MSDATLIANDAKNIVQAHLDRLGEPKDNRLSEEAKQQKFAQIEAELKKRDAVLVAHYYCDPDVQELAEKTGGCVSDSLEMARFGRDHAASTLVVAGVKFMGETAKILSPEKTILMPTLEATCSLDLGCSVDEFTAFCDQHPDHTVVVYANTSAAVKARADWVVTSSCAVEIVEHLDSLGEKIIWAPDQHLGRYIQKKTGADMLLWDGACIVHEEFRARGIANMKALYPDAAVLVHPESPESVVEIADAVGSTSQLIKAAQTLPHQRLIVATDRGIFYKMQQAVPVKILVEAPTAGEGATCRSCAHCPWMAMNELDGILEVLQKGDQEIHVDSALAERAKMPLDRMLAFSASLKR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200--...--....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSD
A
T
L
I
A
N
D
A
K
N
I
V
Q
A
H
L
D
RLGEPKD
N
R
L
S
E
E
A
K
Q
Q
K
F
A
Q
I
E
A
E
L
KKR
D
A
V
L
V
A
H
YYCDP
D
V
Q
E
L
A
E
KTGGC
V
S
D
S
L
E
M
A
R
FGRDH
A
A
S
T
L
V
V
A
G
V
K
F
MG
E
T
A
K
ILSPE
K
T
I
L
M
PTLE
A
T
C
SLDLGC
S
V
D
E
F
T
A
F
C
DQHPD
H
T
V
V
V
Y
ANTS
A
A
V
K
A
RA
D
W
V
V
T
S
S
C
A
V
E
I
V
E
H
L
D
S
LGE
K
I
I
WA
P
D
Q
H
L
G
R
Y
I
Q
K
KTGA
D
M
--
L
L
W--D
G
A
C
I
V
H
E
E
F
R
ARGIA
N
M
K
ALYPD
A
A
V
L
VHPES
P
E
S
V
V
E
I
A
D
AVG
S
T
S
Q
L
I
K
A
A
Q
TLPH
Q
R
L
I
V
ATDRG
I
F
Y
K
MQQAV
P
V
K
I
L
V
EAPTAGEG
A
T
C
R
SCAHCP
W
M
A
M
N
E
L
D
G
I
L
E
V
L
Q
KGD
Q
E
I
H
V
D
S
A
L
A
E
R
AKM
P
L
D
R
M
L
A
F
S
ASLKR
32
HHSearch
91.15
36%
-52
* C2 *
-
5KTR
2
NADA_PYRHO
A:
[4-304]
----------------------------------
T
M
D
L
V
E
E
I
L
R
L
K
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
----
D
F
I
G
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
--
S
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
C
E
--
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
R
---------
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
K
----
22
Fugue
90.80
35%
-118
- C2 -
-
1WZU
-
NADA_PYRHO
A:
[1-298]
-----------------------------------
M
D
L
V
E
E
I
L
R
L
K
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
V
------------
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
-------------
K
K
I
I
P
V
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
C
E
--
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
R
E
D
A
F
C
A
-------------
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
------
34
HHSearch
90.76
34%
-55
- C2 -
-
5F33
2
NADA_THEMA
A:
[8-305]
-------------------------------------
M
V
D
E
I
L
K
L
K
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
----
D
F
V
G
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
F
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
--
S
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
I
T
I
P
E
--
N
G
H
C
P
V
H
Q
-
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
E
----------
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
E
L
M
G
----
33
HHSearch
90.07
34%
-52
- C2 -
-
4P3X
3
NADA_THEMA
A:
[8-305]
-------------------------------------
M
V
D
E
I
L
K
L
K
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
----
D
F
V
G
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
Y
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
--
S
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
I
T
I
P
E
--
N
G
H
C
P
V
H
Q
-
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
E
----------
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
E
L
M
G
----
6
PsiBlast_PDB
89.81
35%
-52
- C2 -
-
5KTS
2
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
5
PsiBlast_PDB
89.26
35%
-51
- C2 -
-
5KTR
2
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
2
PsiBlast_PDB
88.69
35%
-57
- C2 -
-
5KTN
2
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
8
PsiBlast_PDB
88.46
35%
-123
- C2 -
-
1WZU
-
NADA_PYRHO
A:
[12-298]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
------------
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
-----------
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
----
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
------
3
PsiBlast_PDB
88.30
35%
-52
- C2 -
-
5KTO
3
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
4
PsiBlast_PDB
87.86
35%
-53
- C2 -
-
5KTP
2
NADA_PYRHO
A:
[16-302]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
------
9
PsiBlast_PDB
87.76
35%
-50
- C2 -
-
4ZK6
2
NADA_PYRHO
A:
[12-299]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
14
PsiBlast_PDB
87.62
33%
-54
- C2 -
-
5F33
2
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
F
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------
11
PsiBlast_PDB
87.56
33%
-57
- C2 -
-
5F35
1
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
Y
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------
21
PsiBlast_CBE
87.55
35%
-57
- C2 -
-
4ZK6
2
NADA_PYRHO
B:
[12-299]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
15
PsiBlast_PDB
87.48
33%
-58
- C2 -
-
5LQM
1
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
F
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
Y
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------
16
PsiBlast_PDB
87.09
33%
-53
- C2 -
-
5LQS
2
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
F
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
Y
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------
13
PsiBlast_PDB
86.87
33%
-59
- C2 -
-
5F3D
2
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
F
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------
1
PsiBlast_PDB
86.77
35%
-44
- C2 -
-
5KTM
1
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
7
PsiBlast_PDB
86.75
35%
-47
- C2 -
-
5KTT
2
NADA_PYRHO
A:
[16-303]
----------------------------------------------
E
E
R
N
A
I
I
L
A
H
N
Y
Q
L
P
E
V
Q
D
I
A
D
F
I
G
----
D
S
L
E
L
A
R
R
A
T
R
V
D
A
D
V
I
V
F
A
G
V
D
F
M
A
E
T
A
K
I
L
N
P
D
K
V
V
L
I
P
S
R
E
A
T
C
A
M
A
N
M
L
K
V
E
H
I
L
E
A
K
R
K
Y
P
N
A
P
V
V
L
Y
V
N
S
T
A
E
A
K
A
Y
A
D
V
T
V
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
D
V
V
I
F
G
P
D
K
N
L
A
H
Y
V
A
K
M
T
G
K
K
I
--
I
P
V
PS
K
G
H
C
Y
V
H
Q
K
F
T
L
D
D
V
E
R
A
K
K
L
H
P
N
A
K
L
M
I
H
P
E
C
I
P
E
V
Q
E
K
A
D
I
I
A
S
T
G
G
M
I
K
R
A
--
C
E
W
D
E
W
V
V
F
T
E
R
E
M
V
Y
R
L
R
K
L
Y
P
Q
K
K
F
Y
P
A
---------
R
E
D
A
F
C
I
G
M
K
A
I
T
L
K
N
I
Y
E
S
L
K
D
M
K
Y
K
V
E
V
P
E
E
I
A
R
K
A
R
K
A
I
E
R
M
L
E
M
S
-----
10
PsiBlast_PDB
86.17
33%
-52
- C2 -
-
4P3X
3
NADA_THEMA
A:
[17-301]
----------------------------------------------
K
E
K
G
Y
I
I
L
A
H
N
Y
Q
I
P
E
L
Q
D
I
A
D
F
V
G
----
D
S
L
Q
L
A
R
K
A
M
E
L
S
E
K
K
I
L
F
L
G
V
D
F
M
A
E
L
V
K
I
L
N
P
D
K
K
V
I
V
P
D
R
S
A
T
C
P
M
A
N
R
L
T
P
E
I
I
R
E
Y
R
E
K
F
P
D
A
P
V
V
L
Y
V
N
S
T
S
E
C
K
T
L
A
D
V
I
C
T
S
A
N
A
V
E
V
V
K
K
L
D
S
--
S
V
V
I
F
G
P
D
R
N
L
G
E
Y
V
A
E
K
T
G
K
K
V
--
I
T
I
PE
N
G
H
C
P
V
H
-
Q
F
N
A
E
S
I
D
A
V
R
K
K
Y
P
D
A
K
V
I
V
H
P
E
C
P
K
P
V
R
D
K
A
D
Y
V
G
S
T
G
Q
M
E
K
I
P
E
R
D
P
S
R
I
F
V
I
G
T
E
I
G
M
I
H
K
L
K
K
K
F
P
D
R
E
F
V
P
L
----------
E
M
A
V
C
V
N
M
K
K
N
T
L
E
N
T
L
H
A
L
Q
T
E
S
F
E
V
I
L
P
K
E
V
I
E
K
A
K
K
P
I
L
R
M
F
--------