@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUR6: (2017-12-19 )
MLERPITFFFRGGQQQVENVVPTMTVLQFLREYTQTGKTRQTGTKEGCAEGDCGACTVVIGELVNDNLQLRSVNACIQFLLTLDGKALFTVEDLHSLLPVQDGTLHPVQQAMVDMHGSQCGFCTPGFIMSLWSMYENEQQSLSKDKISDYLSGNLCRCTGYRPILDAAQKAYDYPRVVLERQKVIDVLKEIRTLPALHLNDQKQQFFAPKTLQDFATLRLQLPQARIVAGSTDVGLWVTKQGRDLGDILYIGQVEELKKIVVTDHTLTIGANVSLSDALIKISDFYPDFQELQRRFASMPIKNAGTLGGNIANGSPIGDSMPALITLGTRLILRVGEQTREIALEDFYLDYQKTALQLGEFVEAIVIPLREGQTRFKFASYKIAKRFEQDISAVCAAISCELDPHYIAHNVRIAFGGMAAIPKRAKYTEAILEDQQITAELIVQAQEALSQDYQPLDDGRASSAYRLHVAKNCLKRFYVEKILSQTLTRVNDLIAMVEI
Atome Classification :
(35 SA)
.........10.......-.20........30........40........50........60..--......70........80..-......90........100.......110.......120.......130.......140--------------.......150.--......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLER
P
I
T
F
F
F
RG
G
Q
Q
Q
V
E
-
N
VV
P
T
M
T
V
L
Q
F
L
R
E
Y
T
QTGKTRQTGTKEGCAEGDC
G
A
C
T
V
V
I
G
E
L--VNDN
L
Q
L
R
S
V
N
A
C
I
Q
F
L
L
TL-DG
K
A
L
F
T
V
E
D
L
H
S
LLPVQDGTL
H
P
V
Q
Q
A
M
V
D
MHGSQCGFC
T
P
G
F
I
M
S
L
W
S
M
Y
E
N
E
Q
Q
SL--------------
S
K
D
K
I
S
D
Y
LSG--N
L
C
RCTGY
R
P
I
L
D
A
A
Q
K
AYDY
P
R
V
V
L
E
R
Q
K
V
I
D
V
L
K
E
I
R
TLPALHLND
Q
K
Q
QFFA
P
K
T
L
Q
D
F
A
T
L
R
LQLPQ
A
R
I
VAGST
D
V
G
L
W
V
TKQGRDLG
D
I
L
Y
IG
Q
V
E
E
L
K
K
I
VVTD
H
T
L
T
IGANVSLS
D
A
L
I
K
I
S
DFYP
D
F
Q
E
L
Q
R
R
F
ASMPIKNAGTLGGNIANGSPIGDS
M
P
A
L
I
T
L
G
T
R
L
I
L
RVG
E
Q
T
R
E
I
A
L
E
D
F
Y
L
D
Y
Q
K
T
A
L
Q
L
G
E
F
V
E
A
I
V
I
PLREGQ
T
R
F
K
F
A
S
Y
K
I
A
K
R
F
E
Q
D
I
S
A
V
C
A
A
I
SCELDPH
Y
I
A
H
N
V
R
I
A
FGGMAAIPKR
A
K
Y
T
E
A
I
LE
D
Q
Q
I
T
A
E
L
I
V
Q
A
Q
E
A
L
S
QDYQPLDDGRAS
S
A
Y
R
L
H
V
A
K
N
C
L
K
R
F
Y
V
E
K
I
L
S
Q
T
L
T
R
V
N
D
L
I
A
MVEI
36
PsiBlast_CBE
84.15
42%
-104
- C5 -
-
1JRO
5
?
G:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
35
PsiBlast_CBE
83.90
42%
-99
- C5 -
-
1JRP
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
37
PsiBlast_CBE
83.89
42%
-103
- C5 -
-
1JRO
3
?
E:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
113
HHSearch
83.68
44%
-99
- C5 -
-
2W3S
4
?
A:
[1-455]
---
M
E
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
------
G
L
T
G
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
R
D
A
--
A
----
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
P
----
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
-----
R
--------------
D
R
K
D
Y
D
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
--
A
---
F
T
L
-----------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
K
S
A
P
----
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
-
S
K
I
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
L
S
G
E
A
V
-------------
22
PsiBlast_CBE
83.59
42%
-98
- C5 -
-
2W55
4
?
E:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
38
PsiBlast_CBE
83.40
42%
-100
- C5 -
-
1JRO
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
30
PsiBlast_CBE
83.40
42%
-101
- C5 -
-
2W3R
9
?
G:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
31
PsiBlast_CBE
83.10
42%
-97
- C5 -
-
2W3R
4
?
E:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
6
PsiBlast_PDB
83.07
42%
-101
- C5 -
-
1JRP
4
?
A:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
2
PsiBlast_PDB
83.05
42%
-100
- C5 -
-
2W3S
4
?
A:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
23
PsiBlast_CBE
82.90
42%
-98
- C5 -
-
2W55
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
5
PsiBlast_PDB
82.86
42%
-102
- C5 -
-
1JRO
4
?
A:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
29
PsiBlast_CBE
82.85
42%
-101
- C5 -
-
2W3S
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
26
PsiBlast_CBE
82.82
42%
-99
- C5 -
-
2W54
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
33
PsiBlast_CBE
82.63
42%
-98
- C5 -
-
1JRP
9
?
G:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
L
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
21
PsiBlast_CBE
82.58
42%
-99
- C5 -
-
2W55
9
?
G:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
32
PsiBlast_CBE
82.56
42%
-98
- C5 -
-
2W3R
4
?
C:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
24
PsiBlast_CBE
82.51
42%
-100
- C5 -
-
2W54
9
?
G:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
4
PsiBlast_PDB
82.50
42%
-102
- C5 -
-
2W55
4
?
A:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
28
PsiBlast_CBE
82.27
42%
-99
- C5 -
-
2W3S
4
?
E:
[3-449]
-----
I
A
F
L
L
N
G
E
T
R
R
V
R
-
I
E
D
P
T
Q
S
L
L
E
W
L
R
A
E
G
L
T
G
------
T
K
E
G
C
N
E
G
D
C
G
A
C
T
V
M
I
------
R
D
A
A
G
S
R
A
V
N
A
C
L
M
M
L
P
Q
I
-
A
G
K
A
L
R
T
I
E
G
I
A
A
----
P
D
G
R
L
H
P
V
Q
Q
A
M
I
D
H
H
G
S
Q
C
G
F
C
T
P
G
F
I
V
S
M
A
A
A
H
D
R
D
R
K
D
Y
--------------
D
-----
D
L
L
A
G
--
N
L
C
R
C
T
G
Y
A
P
I
L
R
A
A
E
A
A
A
G
E
P
P
A
D
W
L
Q
A
D
A
A
F
T
L
----------------
P
A
F
L
P
E
T
S
D
A
L
A
D
W
Y
L
A
H
P
E
A
T
L
I
A
G
G
T
D
V
S
L
W
V
T
K
A
L
R
D
L
P
E
V
A
F
L
S
H
C
K
D
L
A
Q
I
R
E
T
P
D
G
Y
G
I
G
A
G
V
T
I
A
A
L
R
A
F
A
E
G
P
H
P
A
L
A
G
L
L
R
R
F
A
S
E
Q
V
R
Q
V
A
T
I
G
G
N
I
A
N
G
S
P
I
G
D
G
P
P
A
L
I
A
M
G
A
S
L
T
L
R
R
G
Q
E
R
R
R
M
P
L
E
D
F
F
L
E
Y
R
K
Q
D
R
R
P
G
E
F
V
E
S
V
T
L
P
----
K
S
A
P
G
L
R
C
Y
K
L
S
K
R
F
D
Q
D
I
S
A
V
C
G
C
L
N
L
T
L
K
G
S
K
I
-
E
T
A
R
I
A
F
G
G
M
A
G
V
P
K
R
A
A
A
F
E
A
A
L
I
G
Q
D
F
R
E
D
T
I
A
A
A
L
P
L
L
A
Q
D
F
T
P
L
S
D
M
R
A
S
A
A
Y
R
M
N
A
A
Q
A
M
A
L
R
Y
V
R
E
-------------------
45
PsiBlast_CBE
44.65
35%
-166
- C5 -
-
4ZOH
5
?
C:
[12-158]
-----
I
T
L
K
I
N
G
E
K
Y
E
T
E
--
V
E
P
R
R
L
L
V
H
V
L
R
E
L
G
F
T
G
------
V
H
I
G
C
D
T
S
N
C
G
A
C
T
V
I
----------
M
N
G
K
S
V
K
S
C
T
V
L
A
V
E
A
-
D
G
A
E
I
L
T
V
E
G
L
-----
A
K
D
G
K
L
H
P
I
Q
E
A
F
W
E
N
H
A
L
Q
C
G
Y
C
T
P
G
M
I
M
E
A
Y
W
L
L
-
R
E
K
P
N
P
--------------
T
E
E
E
I
R
E
G
I
S
G
--
N
L
C
R
C
T
G
Y
Q
N
I
V
K
A
I
K
A
A
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
35.82
34%
-94
- C5 -
-
5G5G
6
YAGT_ECOLI
A:
[62-223]
----
P
L
T
L
K
V
N
G
K
T
E
Q
L
E
--
V
D
T
R
T
T
L
L
D
T
L
R
E
-----
N
L
H
L
I
G
T
K
K
G
C
D
H
G
Q
C
G
A
C
T
V
----
L
--
V
N
G
----
R
R
L
N
A
C
L
T
L
A
V
M
H
-
Q
G
A
E
I
T
T
I
E
G
L
G
S
-----
P
D
N
L
H
P
M
Q
A
A
F
I
K
H
D
G
F
Q
C
G
Y
C
T
S
G
Q
I
C
S
S
V
A
V
L
K
E
I
Q
D
G
I
PSHVTVDLVSAPET
T
A
D
E
I
R
E
R
M
S
G
--
N
I
C
R
C
G
A
Y
A
N
I
L
A
A
I
E
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
34.49
44%
-55
- C5 -
-
1FIQ
4
XDH_BOVIN
A:
[8-157]
--------
F
F
V
N
G
K
K
V
V
E
K
N
A
D
P
E
T
T
L
L
A
Y
L
R
R
-----
K
L
G
L
R
G
T
K
L
G
C
G
E
G
G
C
G
A
C
T
V
M
L
S
K
Y
D
R
L
Q
D
K
I
I
H
F
S
A
N
A
C
L
A
P
I
C
T
L
-
H
H
V
A
V
T
T
V
E
G
I
G
S
----
T
K
T
R
L
H
P
V
Q
E
R
I
A
K
S
H
G
S
Q
C
G
F
C
T
P
G
I
V
M
S
M
Y
T
L
L
R
N
Q
P
E
P
---------------
T
V
E
E
I
E
D
A
F
Q
G
--
N
L
C
R
C
T
G
Y
R
P
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
34.14
34%
-87
- C5 -
-
5G5H
4
YAGT_ECOLI
A:
[62-223]
----
P
L
T
L
K
V
N
G
K
T
E
Q
L
E
--
V
D
T
R
T
T
L
L
D
T
L
R
E
-----
N
L
H
L
I
G
T
K
K
G
C
D
H
G
Q
C
G
A
C
T
V
----
L
--
V
N
G
----
R
R
L
N
A
C
L
T
L
A
V
M
H
-
Q
G
A
E
I
T
T
I
E
G
L
G
S
-----
P
D
N
L
H
P
M
Q
A
A
F
I
K
H
D
G
F
Q
C
G
Y
C
T
S
G
Q
I
C
S
S
V
A
V
L
K
E
I
Q
D
G
I
PSHVTVDLV
S
A
P
E
T
T
A
D
E
I
R
E
R
M
S
G
--
N
I
C
R
C
G
A
Y
A
N
I
L
A
A
I
E
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
26.49
37%
-45
- C5 -
-
1VLB
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
25.84
37%
-46
- C5 -
-
1SIJ
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
25.69
37%
-43
- C5 -
-
3L4P
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
25.49
37%
-42
- C5 -
-
3FAH
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
25.31
37%
-42
- C5 -
-
3FC4
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
25.29
37%
-44
- C5 -
-
4C80
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
24.85
37%
-42
- C5 -
-
4US9
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
24.76
37%
-39
- C5 -
-
4C7Z
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
24.75
37%
-46
- C5 -
-
4US8
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
24.50
37%
-44
- C5 -
-
4USA
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
24.30
37%
-40
- C5 -
-
4C7Y
3
MOP_DESGI
A:
[34-152]
------------------------------------------
T
G
V
K
V
G
C
E
Q
G
Q
C
G
A
C
S
V
I
----------
L
D
G
K
V
V
R
A
C
V
T
K
M
K
R
V
A
D
G
A
Q
I
T
T
I
E
G
V
G
-----
Q
P
E
N
L
H
P
L
Q
K
A
W
V
L
H
G
G
A
Q
C
G
F
C
S
P
G
F
I
V
S
A
K
G
L
L
D
T
N
A
D
P
---------------
S
R
E
D
V
R
D
W
F
Q
K
H
R
N
A
C
R
C
T
G
Y
K
P
L
V
D
A
V
M
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------