@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUU2: (2017-12-20 )
MSGLQEEYLQHQTKIEQLRLSIQYIRWYLVSLILLCLISAIIFFCYFTSYITNFIWSIGFTILTLTCLLFVPKLLTHYRDIHFIKKTDLVLQGICLASGILMGINIIVLHFSLPDTLISVSDVHILIALFITSAHIIGLTFLTQQPRYFYLLFIPSTVPLIIGQFTHSQITQLPFYFAYNLAFVATLLCAYATQRNYQKISQLLFKNKQLVQVAEQHTQWAEELCVQLQQEVNKSKDIEAQLQFNNHLLEQKVRERTYDLTKMNERLESHHHNLAFAHETAGIRPWDWDIEKQKLEITFFDQQKQTQNTPLHLKSILERIHPNDRKLFDERLKEHLEGKSDHFNITFRILRRNGSWRWIHDVGRVISRDPKTNKALRMVGMTRDIHQEKKDQEHLRLSAIVLEQAAEGIFILDEKLNYIEVNPYYEKLTGFSKSELLSQQLFNITINQKLQQQQFHDSITQQLLKTGEYMGQFDEKFTSGKSVYLWLHINAVKDEYNQIINYIGFARDLTEQKRQEQHLSYLKNYDSLTHLPNRFYYYNQLHQYLVNPSYSFKNLALIRINIDRFRAFNEFLNNDSGDELLKQFAQRLRLTNINAILVAYLNGDDFAIIYEISPIHPNIEQYCQNILQALNAPFYIDEQEYFITASIGVACFPEHGRQIDHLNNHAEQALSEAKRLGGNTISYYCNKTTNPYKTADLEQELRKAIQNDEFVVYYQPKINLNDKSIKGFEALIRWQHPEKGLVMPNMFIPFAERSSLISDIGKVVLDKVGKQLQEWKKAGYADVRVSVNIVAQQIHRGLLLSDLDEVLDTYHLDGSNLELEITESALLDNTDNVKKLLHSIKERNISIALDDFGTGYSSLAYLTEYPIDVLKIDQAFVSKIGDQKQEAIVNAMIAMGKSMGLKLVAEGVETEEQVIYLQKQQCDFLQGFFFSRPLHPNQILQYLQTNTHI
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.....----..620-----.........630.......640.......650.......660.......670.......680..-.....690-.......700.......710.......720.......730.......740.......750.......760.......770.......780-........790.......800.......810.......820.......830.......840.......850.......860.......870.......880.-.-....-..890.......900.......910.......920.......930.......940.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
G
L
Q
E
E
Y
L
Q
H
Q
T
K
I
E
Q
L
R
L
S
I
Q
Y
I
R
W
Y
L
V
S
L
I
L
L
C
L
I
S
A
I
I
F
F
C
Y
F
T
S
Y
I
T
N
F
I
W
S
I
G
F
T
I
L
T
L
T
C
L
L
F
V
P
K
L
L
T
H
Y
R
D
I
H
F
I
K
K
T
D
L
V
L
Q
G
I
C
L
A
S
G
I
L
M
G
I
N
I
I
V
L
H
FSLPD
T
L
ISV
S
D
V
H
I
L
I
A
L
F
I
TS
A
H
I
I
G
L
T
F
LTQQP
R
Y
F
Y
L
L
FIPSTV
P
L
I
I
GQF
T
H
S
Q
I
TQ
L
P
F
Y
F
A
Y
N
L
A
F
V
A
T
L
L
C
A
Y
ATQR
N
Y
Q
K
I
S
Q
L
L
FK
N
K
Q
L
V
Q
V
A
E
Q
H
T
Q
W
A
E
E
L
C
V
Q
L
Q
Q
E
VNKSKD
I
E
A
Q
L
QF
N
N
H
L
L
E
Q
K
V
R
E
RTY
D
L
T
K
M
N
E
R
L
E
S
HHH
N
L
A
F
AHETAGIRPWDWDIE
K
Q
K
L
E
I
T
F
F
DQQKQTQNTP
L
H
L
K
S
I
L
E
R
IHPN
D
R
K
L
F
D
E
R
L
K
E
H
LEGKSD
H
F
N
I
T
F
R
I
L
RRNGS
W
R
W
I
H
D
V
G
R
V
ISRDPKT
N
K
A
L
R
M
VGM
T
R
D
I
H
Q
E
K
K
D
Q
E
H
L
R
L
S
A
I
V
L
E
QAAE
G
I
F
I
L
DEKL
N
Y
I
E
V
N
P
Y
Y
E
K
LTGF
S
K
S
E
L
L
S
Q
Q
L
F
N
I
T
I
N
Q
K
L
Q
Q
Q
Q
F
H
D
S
I
T
Q
Q
L
L
K
T
G
E
Y
M
G
Q
F
D
E
KFTSG
K
S
V
Y
L
W
L
H
I
N
A
V
K
D
E
Y
N
Q
I
I
N
Y
IGF
A
R
D
L
T
E
Q
K
R
Q
E
Q
H
L
S
Y
L
K
N
Y
D
S
L
THLP
N
R
F
Y
Y
Y
N
Q
L
H
Q
Y
LVNPSYSF
K
N
L
A
L
I
R
I
N
I
D
R
F
R
A
F
N
E
F
LNND
S
G
D
E
L
L
K
Q
F
A
Q
R
LRLTNI
N
A
I
L
V
A
Y
LNGD
D
F
A
I
I
Y
E
ISPIHP----
N
I
E
-------
Q
Y
C
Q
N
I
L
Q
A
LNA
P
F
Y
IDEQ
E
Y
F
I
T
A
SIG
V
A
CFPEHGRQ
I
D
H
L
N
N
H
A
E
Q
A
L
S
E
A
K
R
LGGN
T
I
S
Y
Y
-CNKTTNPY-KT
A
D
L
E
Q
E
L
R
K
A
IQND
E
F
V
V
Y
YQ
P
K
INLNDKS
I
K
G
F
E
A
L
I
RWQHPEKGLVMPNMFIP
F
A
E
R
S
S
L
I
S
D
I
G
K
V
V
L
D
K
V
G
K
Q
L
Q
E
W
K
KAGY
A
--
D
V
R
V
S
V
N
I
V
A
Q
Q
I
H
R
G
L
L
L
S
D
L
D
E
V
L
D
T
YHLDGS
N
L
E
L
E
IT
E
S
ALLDN
T
D
N
V
K
K
L
L
H
S
I
K
ERN
I
S
I
A
LDDFGT
G
Y
S
S
L
A
Y
L
T
EYPI
D
V
L
KI
D
Q
A
F
V
S
K
IG-
D
-
Q
-
K
Q
E
A
-
I
V
N
A
M
I
A
M
G
KSM
G
L
K
L
V
AEGVETE
E
Q
V
I
Y
L
Q
K
QQ
C
D
F
L
Q
G
F
F
FSRPL
H
P
N
Q
I
L
Q
Y
L
Q
TNTHI
45
HHSearch
82.21
37%
-16
- C2 -
-
4RNH
1
?
A:
[21-449]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
-------
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
-
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
E
Q
D
A
Q
-
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
-----
44
HHSearch
80.06
36%
-16
- C2 -
-
4RNF
-
?
A:
[1-430]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
P
S
Q
G
D
R
E
I
A
L
K
R
A
I
-------
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
-
Q
A
E
M
N
A
R
A
L
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
E
Q
D
A
Q
-
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
S
----
1
PsiBlast_PDB
78.71
37%
-16
- C2 -
-
4RNH
1
?
A:
[21-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
R
F
------
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
---
P
S
Q
G
----
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
-
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
-
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-----------
2
PsiBlast_PDB
78.14
37%
-15
- C2 -
-
4RNF
-
?
A:
[1-423]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Y
Y
D
A
L
T
H
L
P
N
R
T
L
F
Q
D
R
L
H
T
A
L
Q
Q
A
E
R
N
G
Q
W
V
V
L
M
F
L
D
L
D
-----
N
D
S
L
G
H
A
A
G
D
R
M
L
Q
E
V
A
T
R
L
S
A
C
V
S
Q
D
D
T
V
A
R
M
G
G
D
E
F
T
L
L
L
---
P
S
Q
G
----
D
R
E
I
A
L
K
R
A
I
Q
V
A
E
L
I
L
G
R
L
A
R
P
F
T
L
E
G
R
E
F
F
V
T
A
S
I
G
V
A
L
S
P
Q
D
G
A
E
L
S
L
L
M
K
N
A
D
T
A
M
Y
H
A
K
E
M
G
K
N
N
F
Q
F
Y
Q
A
E
M
N
A
R
A
L
-
E
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
N
N
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
-
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-----------
13
PsiBlast_PDB
68.72
37%
-104
- C2 -
-
4Y9N
-
?
A:
[5-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
49
HHSearch
68.53
37%
-92
- C2 -
-
4RNI
-
?
A:
[4-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
E
Q
D
A
Q
-
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
F
G
M
L
Y
A
S
----
4
PsiBlast_PDB
68.35
42%
-87
- C2 -
-
4RNJ
-
?
A:
[6-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
-
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-----------
12
PsiBlast_PDB
68.34
37%
-104
- C2 -
-
4Y9M
-
?
A:
[5-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
53
HHSearch
67.55
37%
-101
- C2 -
-
4Y9M
-
?
A:
[5-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
-
I
D
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
T
V
Q
E
--
15
PsiBlast_PDB
67.52
37%
-104
- C2 -
-
4Y9O
-
?
A:
[5-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
22
PsiBlast_CBE
66.49
37%
-94
- C2 -
-
4Y9P
2
?
B:
[5-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
-----
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
3
PsiBlast_PDB
66.29
42%
-91
- C2 -
-
4RNI
-
?
A:
[6-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
E
S
D
L
R
R
A
L
E
L
G
E
F
V
L
H
Y
Q
P
Q
F
T
G
D
G
R
R
L
T
G
A
E
A
L
L
R
W
Q
H
P
R
R
G
L
V
P
P
S
E
F
I
P
V
L
E
E
I
G
L
V
A
Q
V
G
D
W
L
L
A
E
A
C
K
Q
L
R
S
W
H
K
A
K
V
R
--
V
P
K
V
S
V
N
L
S
A
R
Q
F
A
D
G
Q
L
G
E
R
I
A
A
I
L
Y
E
T
G
I
P
P
A
C
L
E
L
E
L
T
E
S
I
L
M
S
D
V
A
E
A
M
Q
I
L
S
G
L
K
R
L
G
L
A
I
A
V
D
D
F
G
T
G
Y
S
S
L
N
Y
L
K
Q
F
P
I
D
V
L
K
I
D
R
S
F
V
D
G
L
P
-
H
-
G
-
E
Q
D
A
Q
I
A
R
A
I
I
A
M
A
H
S
L
N
L
M
V
I
A
E
G
V
E
S
Q
A
Q
L
D
F
L
R
E
H
G
C
D
E
V
Q
G
Y
L
F
G
R
P
M
P
A
E
Q
-----------
18
PsiBlast_PDB
66.17
37%
-96
- C2 -
-
5MF5
1
?
A:
[1-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
24
PsiBlast_CBE
65.99
37%
-91
- C2 -
-
5MKG
2
?
A:
[1-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
--------
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
5
PsiBlast_PDB
65.86
39%
-86
- C2 -
-
5M1T
1
Y1727_PSEAE
A:
[31-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
H
D
L
R
Q
A
L
E
R
R
Q
L
V
L
H
Y
Q
P
K
V
L
A
P
N
G
P
M
I
G
V
E
A
L
L
R
W
E
H
P
Q
H
G
L
I
T
P
G
Q
F
L
P
L
A
E
K
T
G
L
I
V
Q
I
G
E
W
V
L
D
E
A
C
R
Q
M
R
L
W
L
D
G
G
H
A
--
D
W
N
I
A
V
N
L
S
A
L
Q
F
A
H
A
G
L
V
D
S
V
R
N
A
L
L
R
H
S
L
E
P
S
H
L
I
L
E
V
T
E
S
T
A
M
R
D
A
D
A
S
L
V
I
L
E
Q
L
S
A
M
G
V
G
I
S
I
D
D
F
G
T
G
Y
S
S
L
L
Y
L
K
R
L
P
A
S
E
L
K
I
D
R
G
F
I
N
E
L
A
H
D
-
S
-
D
D
A
A
-
I
V
S
A
I
V
A
L
G
R
T
L
N
L
K
I
V
A
E
G
V
E
T
E
A
Q
Q
E
F
L
T
R
L
G
C
N
S
L
Q
G
F
L
L
G
R
P
M
P
A
E
Q
L
L
---------
16
PsiBlast_PDB
65.69
37%
-100
- C2 -
-
5MKG
2
?
B:
[5-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
-----
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
54
HHSearch
65.50
37%
-94
- C2 -
-
5MF5
1
?
A:
[3-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
-
I
-
D
T
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
T
V
Q
E
--
52
HHSearch
64.60
36%
-86
- C2 -
-
5M1T
1
Y1727_PSEAE
A:
[31-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
H
D
L
R
Q
A
L
E
R
R
Q
L
V
L
H
Y
Q
P
K
V
L
A
P
N
G
P
M
I
G
V
E
A
L
L
R
W
E
H
P
Q
H
G
L
I
T
P
G
Q
F
L
P
L
A
E
K
T
G
L
I
V
Q
I
G
E
W
V
L
D
E
A
C
R
Q
M
R
L
W
L
D
G
G
H
A
--
D
W
N
I
A
V
N
L
S
A
L
Q
F
A
H
A
G
L
V
D
S
V
R
N
A
L
L
R
H
S
L
E
P
S
H
L
I
L
E
V
T
E
S
T
A
M
R
D
A
D
A
S
L
V
I
L
E
Q
L
S
A
M
G
V
G
I
S
I
D
D
F
G
T
G
Y
S
S
L
L
Y
L
K
R
L
P
A
S
E
L
K
I
D
R
G
F
I
N
E
L
A
-
H
D
S
-
D
D
A
A
-
I
V
S
A
I
V
A
L
G
R
T
L
N
L
K
I
V
A
E
G
V
E
T
E
A
Q
Q
E
F
L
T
R
L
G
C
N
S
L
Q
G
F
L
L
G
R
P
M
P
A
E
Q
L
L
---------
14
PsiBlast_PDB
63.70
37%
-85
- C2 -
-
4Y9P
2
?
A:
[3-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
--------
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
17
PsiBlast_PDB
63.40
37%
-96
- C2 -
-
5MFU
2
?
A:
[1-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
P
S
S
E
L
R
R
A
L
E
A
N
E
F
I
P
Y
Y
Q
P
L
S
P
G
Q
G
G
R
W
I
G
V
E
V
L
M
R
W
R
H
P
R
E
G
L
I
R
P
D
L
F
I
P
F
A
E
R
S
G
L
I
V
P
M
T
R
A
L
M
R
Q
V
A
E
D
L
G
G
H
A
G
K
L
E
P
--
G
F
H
I
G
F
N
I
S
A
T
H
C
H
E
L
A
L
V
D
D
C
R
E
L
L
A
A
F
P
P
G
H
I
T
L
V
L
E
L
T
E
R
E
L
I
E
S
S
E
V
T
D
R
L
F
D
E
L
H
A
L
G
V
K
I
A
I
D
D
F
G
T
G
H
S
S
L
A
Y
L
R
K
F
Q
V
D
C
L
K
I
D
Q
S
F
V
A
R
I
G
I
D
-
T
-
L
S
G
H
-
I
L
D
S
I
V
E
L
S
A
K
L
D
L
D
I
V
A
E
G
V
E
T
P
E
Q
R
D
Y
L
A
A
R
G
V
D
Y
L
Q
G
Y
L
I
G
R
P
M
P
L
E
S
L
L
S
S
L
------
21
PsiBlast_CBE
61.45
39%
-83
- C2 -
-
5M1T
1
B:
[44-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
L
V
L
H
Y
Q
P
K
V
L
A
P
N
G
P
M
I
G
V
E
A
L
L
R
W
-----
G
L
I
T
P
G
Q
F
L
P
L
A
E
K
T
G
L
I
V
Q
I
G
E
W
V
L
D
E
A
C
R
Q
M
R
L
W
L
----
A
--
D
W
N
I
A
V
N
L
S
A
L
Q
F
A
H
A
G
L
V
D
S
V
R
N
A
L
L
R
H
S
L
E
P
S
H
L
I
L
E
V
T
E
S
T
A
M
R
D
A
D
A
S
L
V
I
L
E
Q
L
S
A
M
G
V
G
I
S
I
D
D
F
G
T
G
Y
S
S
L
L
Y
L
K
R
L
P
A
S
E
L
K
I
D
R
G
F
I
N
E
L
A
H
D
-
S
-
D
D
A
A
-
I
V
S
A
I
V
A
L
G
R
T
L
N
L
K
I
V
A
E
G
V
E
T
E
A
Q
Q
E
F
L
T
R
L
G
C
N
S
L
Q
G
F
L
L
G
R
P
M
P
A
E
Q
L
L
---------
30
PsiBlast_CBE
60.00
31%
-100
- C2 -
-
4LJ3
3
YAHA_ECOLI
B:
[28-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
S
L
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
L
P
D
--
N
F
H
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
-
E
-
I
S
G
H
-
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
I
S
--------
31
PsiBlast_CBE
59.56
31%
-104
- C2 -
-
4LJ3
3
YAHA_ECOLI
A:
[28-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
I
S
L
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
L
P
D
--
N
F
H
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
V
D
-
E
-
I
S
G
H
-
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
I
S
--------
58
HHSearch
59.55
30%
-101
- C2 -
-
4LJ3
3
YAHA_ECOLI
A:
[22-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
V
T
P
E
A
I
S
L
A
L
E
N
H
E
F
K
P
W
I
Q
P
V
F
C
A
Q
T
G
V
L
T
G
C
E
V
L
V
R
W
E
H
P
Q
T
G
I
I
P
P
D
Q
F
I
P
L
A
E
S
S
G
L
I
V
I
M
T
R
Q
L
M
K
Q
T
A
D
I
L
M
P
V
K
H
L
L
P
D
--
N
F
H
I
G
I
N
V
S
A
G
C
F
L
A
A
G
F
E
K
E
C
L
N
L
V
N
K
L
G
N
D
K
I
K
L
V
L
E
L
T
E
R
N
P
I
P
V
T
P
E
A
R
A
I
F
D
S
L
H
Q
H
N
I
T
F
A
L
D
D
F
G
T
G
Y
A
T
Y
R
Y
L
Q
A
F
P
V
D
F
I
K
I
D
K
S
F
V
Q
M
A
S
-
V
-
D
E
I
S
G
H
-
I
V
D
N
I
V
E
L
A
R
K
P
G
L
S
I
V
A
E
G
V
E
T
Q
E
Q
A
D
L
M
I
G
K
G
V
H
F
L
Q
G
Y
L
Y
S
P
P
V
P
G
N
K
F
I
S
E
W
V
-----
7
PsiBlast_PDB
58.03
42%
-17
- C2 -
-
3N3T
1
?
A:
[27-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
T
R
L
R
Q
A
L
E
R
N
E
L
V
L
H
Y
Q
P
I
V
E
L
A
S
G
R
I
V
G
G
E
A
L
V
R
W
E
D
P
E
R
G
L
V
M
P
S
A
F
I
P
A
A
E
D
T
G
L
I
V
A
L
S
D
W
V
L
E
A
C
C
T
Q
L
R
A
W
Q
Q
Q
G
R
A
AD
D
L
T
L
S
V
N
I
S
T
R
Q
F
E
G
E
H
L
T
R
A
V
D
R
A
L
A
R
S
G
L
R
P
D
C
L
E
L
E
I
T
E
N
V
M
L
V
M
T
D
E
V
R
T
C
L
D
A
L
R
A
R
G
V
R
L
A
L
D
D
F
G
T
G
Y
S
S
L
S
Y
L
S
Q
L
P
F
H
G
L
K
I
D
Q
S
F
V
R
K
I
P
-
A
-
H
-
P
S
E
T
Q
I
V
T
T
I
L
A
L
A
R
G
L
G
M
E
V
V
A
E
G
I
E
T
A
Q
Q
Y
A
F
L
R
D
R
G
C
E
F
G
Q
G
N
L
M
S
T
P
----------------
32
PsiBlast_CBE
42.94
37%
-66
- C2 -
-
3GG1
1
?
B:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
33
PsiBlast_CBE
42.59
37%
-68
- C2 -
-
3GG1
1
?
A:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
35
PsiBlast_CBE
42.05
37%
-57
- C2 -
-
3GG0
1
?
A:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
38
PsiBlast_CBE
41.43
37%
-69
- C2 -
-
3GFX
1
?
B:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
34
PsiBlast_CBE
40.56
37%
-68
- C2 -
-
3GG0
1
?
B:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
36
PsiBlast_CBE
40.20
37%
-63
- C2 -
-
3GFZ
1
?
B:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
39
PsiBlast_CBE
39.63
37%
-57
- C2 -
-
3GFX
1
?
A:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------
37
PsiBlast_CBE
38.92
37%
-59
- C2 -
-
3GFZ
1
?
A:
[279-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
V
T
E
T
E
V
I
T
C
F
D
Q
F
R
K
V
L
K
A
L
R
V
A
G
M
K
L
A
I
D
D
F
G
A
G
Y
S
G
L
S
L
L
T
R
F
Q
P
D
K
I
K
V
D
A
E
L
V
R
D
I
H
I
S
-
G
-
T
K
Q
A
-
I
V
A
S
V
V
R
C
C
E
D
L
G
I
T
V
V
A
E
G
V
E
T
L
E
E
W
C
W
L
Q
S
V
G
I
R
L
F
Q
G
F
L
F
S
R
P
----------------