@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TYU7: (2017-12-15 )
MREKLKGGNIMKKWLLLLIGMGILFTGCTSENTRTKATIETDTTIETKKSKTQSTEQTTTEMKQSVETSASSITESSSEEVKNTLWDTNKASKLETFVTQWGKTLGQEYKSYNLQNNVSLYGTPLPQAVINGDWKMAINEAPVTVQWSEDGTGHADFNLVAVYSDVETGEYLGQHVYFFGFQNGQPKVYLTQQNQGNENNYLYFNETQNQQLKQGFSDIVNGQTPQTPVVEESTQQATTTTTQSTSSSGISSWEAAKESVLNNKALWLYDSPDKNVSNTNLISTNEYMKDLMQDENGSYYSINIVTDDDGNTTMAGGKQFRVYTDGRISQRIGMTNNFQMIK
Atome Classification :
(16 SA)
------------------------....-----.....10........---------20.....--------------.--------..30........------40....-....50........60.-------.......70.....-.--..80..---......90---.........-100.....-..110--.-........120.-.--------.....-130--------------------------------.......-140-...-----..--------..150........-----160...------....170--....--------...180.......190........200.......210-------------------.........---220.......230....-----...240..-------------------.....250.....--..260--.......-----.270-----------...----....-.280.......290.---.-...--.---.300--.-------.------......310--------...------.----.....320---...--.....330.......340---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MREK-----LKG
G
N
I
M
K
K
W
L
L
L
L
I
---------
G
M
G
I
L
F
T--------------G--------CTSENTR
T
K
A
T
I
------ETD
T
T
I
-ETKKSKTQST
E
Q
T
T
T
E
M
-------
K
Q
S
V
E
T
S
A
S
SITES-
S
--
S
E
E
V
K
N
---
T
LWDTN
K
----
A
S
K
L
E
T
F
V
T
-
Q
W
G
K
T
L
G
Q
-
E
Y
K
----S-YNLQNN
V
S
L
YGT-P--------L
P
Q
A
V-ING--------------------------------D
W
K
M
A
IN-EA
P
-
V
T
V
-----
Q
W--------SED-GTGHA
D
F
N
L
-----
V
A
V
Y
SD------V
E
T
G
E
Y
L--G
Q
H
V
--------
Y
F
F
G
FQNGQ
P
K
V
Y
L
T
-QQNQGNEN
N
Y
L
Y
F
NETQ
N
Q
---------------------
Q
L
K
Q
G
F
S
D
I
---VNGQTPQTPVVEESTQQ-----
A
T
T
T
TTQS-------------------TSSSGI
S
S
W
E
A
A
K
--
E
S
VL---NNK
A
L
W
L
-----YDS------------PDK----NVSN-TNLI
S
T
N
E
Y
M
K
D
L
M
Q---D-ENG--
S
---
Y
Y
S
---
I
-------
N
------
I
V
TDDDG----------NTT------M----AG
G
K
Q
F
R
----
V
Y
T--DGR
I
S
Q
RIGMTNN
F
Q
MIK---------------------------------------------
73
Fugue
72.10
16%
54
* C5 *
-
4OPU
3
?
A:
[2-453]
------------------------
M
K
E
L
K
Y
D
V
L
I
I
G
G
G
F
A
G
S
S
A
A
Y
Q
L
SRR------
G
L
K
I
L
L
V
D
SKPWNRIGDKPCG
D
--------
A
V
S
K
A
H
F
D
K
L
G
M
PYPKGE
E
L
E
N
K
I
-
N
G
I
K
L
Y
S
P
D
M
Q
T
V
W
T
V
N
-------
H
E
G
F
E
L
N
A
P
L
Y
N
Q
R
-
V
--
L
K
E
A
Q
D
R
G
V
E
I
W
D
-------
L
T
T
A
M
K
P
I
F
-
E
D
G
Y
V
K
G
A
-
V
L
F
----
N
-
R
R
T
N
E
E
L
T
V
Y
S
K
-
V
--------
V
V
E
A
T
G
Y
S
R
--------------------------------
S
F
R
S
K
L
P
P
E
L
P
-
I
T
E
-----
D
L
--------
D
D
K
-
D
A
D
V
A
Y
R
E
V
-----
L
L
T
K
E
D
------
I
E
D
H
D
Y
L
--
R
I
F
I
D
QETSPG
G
Y
W
W
Y
F
P
K
G
K
N
K
V
N
V
G
-
L
G
I
Q
G
G
M
G
-
Y
P
S
I
H
E
Y
Y
K
K
---------------------
Y
L
D
K
Y
A
P
D
V
---
D
K
S
K
L
L
V
K
G
G
A
L
V
P
T
R
R
-----
P
L
Y
T
M
A
W
N
G
I
I
V
I
G
DSGFTVNPVHGGG
K
G
S
A
M
I
S
G
Y
C
A
A
K
A
I
L
S
A
F
E
T
G
D
F
S
A
S
G
L
-----
W
D
M
------------
N
I
C
----
Y
V
N
E
Y
G
A
K
Q
A
S
L
D
I
F
R
R
F
L
Q
K
LS
N
-
D
D
I
--
N
---
Y
G
M
---
K
-------
K
------
K
I
I
K
E
E
D
----------
L
L
E
------
A
----
S
E
K
G
D
L
H
----
L
S
V
--
A
D
K
A
M
R
V
I
S
G
L
G
R
P
S
L
L
F
K
L
K
A
V
A
E
S
M
K
K
I
K
E
L
Y
L
N
YPRSPSS
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
76
Fugue
69.17
15%
60
- C3 -
-
4GA6
1
AMPPA_THEKO
A:
[1-493]
M
K
A
K
I
R
I
L
DMFSGRY
T
V
L
I
N
E
E
D
A
K
E
A
K
-----
L
H
P
D
D
L
V
K
I
E
A
G
K
K
A
---------
V
Y
G
S
V
A
L
--------------
S
NLVGKG
E
V
G
I
S
R
D
V
L
D
L
H
N
F
------
S
E
G
E
T
V
-
S
V
I
P
A
G
T
P
E
S
V
R
Y
I
K
K
K
M
H
G
E
K
L
R
K
V
E
I
E
A
I
V
R
D
I
V
D
R
-
K
LR
D
I
E
I
S
S
---
F
V
T
A
L
E
I
N
GLD
M
D
E
I
A
A
L
T
I
-
A
M
A
E
T
G
D
M
L
D
I
D
----
R
-
K
P
I
M
D
V
H
S
I
G
G
V
-
P
GNK
T
N
I
L
V
V
P
I
V
A
-
A
A
G
LTIP
K
T
S
S
R
A
ITSAAG
T
A
D
V
V
E
V
F
ADVSFS
L
D
E
I
K
R
I
V
E
-
K
V
G
-
A
C
L
-----
V
W
GGALNLA
P
A
D
D
-
I
T
I
K
A
E
R
A
L
SIDP
T
G
L
M
L
A
S
------
I
M
S
K
K
Y
A
M
G
S
Q
Y
V
--------
L
I
D
I
P
T
G
K
G
V
K
V
E
T
V
-
E
E
A
R
S
L
A
R
D
F
I
E
L
G
K
R
L
G
Q
Y
V
E
V
A
ITYGGQPIGHTVGP
A
L
E
A
R
E
A
L
S
A
L
---
M
T
G
K
G
P
-
G
S
L
I
E
K
A
T
G
L
-----
A
G
I
L
L
E
M
G
-------------------
G
V
A
P
A
G
T
G
K
K
M
A
K
--
E
I
L
E
---
S
G
K
A
W
E
K
-----
M
K
E
I
I
E
A
Q
GGDPNIK
P
E
E
IPIG
D
K
T
Y
-
T
F
T
A
A
T
S
G
Y
V
T
A
I
D
N
---
R
-
A
I
T
--
A
---
I
A
R
---
A
-------
A
------
G
A
P
E
D
K
G
A
G
I
E
L
YVKVG
E
K
V
------
K
----
E
G
D
P
L
F
T
----
I
H
A
EH
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
E
P
I
R
IE-------------------------------------------
81
Fugue
66.78
13%
12
- C5 -
-
1S3I
5
AL1L1_RAT
A:
[1-307]
------------------------------------------
M
K
I
A
V
I
---------
G
Q
S
L
F
G
Q
--------------
E
--------
V
Y
C
Q
L
R
K
E
G
H
E
V
------
V
G
V
F
T
I
-
P
D
K
D
G
K
A
D
P
D
G
L
E
A
E
K
D
-------
G
V
P
V
F
K
F
P
R
W
---
R
-
A
--
R
G
Q
A
L
P
---
E
V
V
A
K
Y
Q
----
A
L
G
A
E
L
N
V
L
P
F
C
S
Q
F
I
P
M
-
E
V
I
----
N
-
A
P
R
H
G
S
I
I
Y
H
P
S
-
L
--------
L
P
R
H
R
-
G
A
S
--------------------------------
A
I
N
W
T
L
I
-------------------------
H
-
G
D
K
K
G
G
F
T
I
-----
F
W
A
D
D
G
------
L
D
T
G
D
L
L
--
L
Q
K
E
--------
C
E
V
L
P
D
D
T
V
S
T
L
Y
N
R
------------
F
L
F
P
E
G
I
K
---------------------
G
M
V
Q
A
V
R
L
I
---
A
E
G
T
A
P
R
C
P
---
Q
S
E
E
G
-----
A
T
Y
E
G
I
Q
K
-------------------
K
E
T
A
K
I
N
W
D
Q
P
A
E
--
A
I
H
N
---
W
I
R
G
N
D
K
-----
V
P
G
------------
A
W
T
----
E
A
C
G
-
Q
K
L
T
F
F
N
S
T
L
N
T
S
G
L
---
S
-
T
Q
G
--
E
---
A
L
P
---
I
-------
P
GAHRPG
V
V
T
K
A
G
L
----------
I
L
F
------
G
----
N
D
D
R
M
L
L
----
V
K
N
--
I
Q
L
E
D
G
K
M
M
P
A
S
Q
F
F
K
-----------------------------------------------
75
Fugue
56.40
14%
49
- C3 -
-
3NOY
2
ISPG_AQUAE
A:
[10-358]
------------------------
M
I
Q
K
-----
R
K
T
R
Q
---------
I
---------
R
V
G
N
V
K
I
--------------
G
--------
G
D
A
-----
P
I
V
V
------
Q
S
M
T
S
------
T
K
T
H
D
V
E
A
T
L
N
Q
I
-------
K
R
L
Y
E
A
G
C
E
I
V
R
V
A
V
P
--
H
K
E
D
V
E
---
A
L
E
E
I
V
K
----
K
S
P
M
P
V
I
A
D
I
H
F
A
P
S
Y
A
F
-
L
S
M
----
E
-
K
G
V
-
H
G
I
R
I
N
P
G
-
N
--------
I
G
K
E
E
-
I
V
R
--------------------------------
E
I
V
E
E
A
K
-
R
R
G
-
V
A
V
-----
R
I
--------
G
V
N
--
S
G
S
L
E
K
D
L
-----
L
E
K
Y
G
Y
PS
A
E
A
L
A
E
S
A
L
R
W
--
S
E
K
F
--------
E
K
W
G
F
T
N
--
Y
K
V
S
I
K
G
S
D
V
L
Q
N
V
R
A
N
L
I
F
A
E
R
T
D
V
---------------------
P
L
H
I
G
I
T
E
A
GMG
T
K
G
I
I
K
S
S
V
G
I
G
I
L
L
Y
M
GIGD
T
V
R
V
S
L
T
D
D
-------------------
P
V
V
E
V
E
T
A
Y
E
I
L
K
--
S
L
G
L
---
R
R
R
G
V
E
I
-----
V
A
C
------------
P
T
C
----
G
R
I
E
-
V
D
L
P
K
V
V
K
E
V
Q
E
K
L
S
---
G
-
V
K
T
P
L
K
---
V
A
V
---
M
-------
G
------
C
V
V
N
A
I
G
----------
E
A
R
EADIGL
A
----
C
G
R
G
F
A
W
----
L
F
K
--
H
G
K
P
I
K
K
V
D
E
S
E
M
V
D
E
L
L
K
E
I
Q
N----------------------------------------
74
Fugue
54.83
14%
39
- C1 -
-
4LDV
5
ARFA_ARATH
A:
[16-356]
-----------------------------------
S
D
A
L
C
R
E
L
W
H
A
C
A
---------
G
---
P
L
V
--------------
T
--------
L
P
R
E
G
E
R
V
Y
Y
F
P
------
E
G
H
M
E
Q
L
E
A
S
M
H
Q
G
L
E
Q
Q
M
P
S
F
N
L
-------
P
S
K
I
L
C
K
V
I
N
I
Q
R
R
-
A
--------------
E
T
D
E
----
V
Y
A
Q
I
T
L
L
P
-
E
L
D
Q
S
E
P
T
-
S
P
D
----
A
-
P
V
Q
E
T
V
H
S
F
C
K
T
L
T
--------
A
S
D
T
S
-
T
H
G
--------------------------------
G
F
S
V
L
R
R
-
H
A
D
-
D
C
L
-----
P
P
--------
L
D
M
-
S
Q
Q
P
P
W
Q
E
L
-----
V
A
T
--
D
------
L
H
N
S
E
W
H
--
F
R
H
I
--------
F
R
-----
G
Q
P
R
R
H
L
L
-
T
------
T
G
W
S
V
F
V
S
S
K
K
-----------------------
L
V
A
G
D
A
F
I
F
--
L
R
G
E
N
E
E
L
R
V
G
---
V
R
R
-----
H
M
P
S
S
V
I
S
-------------------
S
H
S
M
H
I
G
V
L
A
T
A
A
--
H
A
I
T
---
T
G
T
I
F
S
V
-----
F
Y
K
------------
P
R
T
----
S
R
S
E
-
F
-
I
V
S
V
N
R
Y
L
E
A
K
T
Q
---
K
L
S
V
G
--
M
---
R
F
K
---
M
R
FK
R
F
S
G
T
------
I
V
G
V
Q
E
N
----------
K
S
S
------
V
----
W
H
D
S
E
W
R
S
L
K
V
Q
W
D
--
E
P
S
S
V
F
R
P
E
R
V
S
P
W
E
L
E
P
L
N-------------------------------------------
77
Fugue
51.06
11%
31
- C3 -
-
5HAF
-
SSEL_SALTY
A:
[13-338]
------------------------
G
L
E
V
-----
L
F
Q
G
P
V
S
D
E
A
L
T
L
L
F
S
A
V
E
N
G
D
Q
N
C
I
D
L
L
C
N
--------------
L
--------
A
L
R
N
D
D
L
G
H
R
V
E
------
K
F
L
F
D
L
-
F
S
G
K
R
T
G
------
S
S
D
I
-------
D
K
K
I
N
Q
A
C
L
V
L
H
Q
I
-
A
--
N
N
D
I
T
K
---
D
N
T
E
W
K
K
----
L
H
A
P
S
R
L
L
Y
-
M
A
G
S
A
T
T
D
-
L
S
K
K
I
G
I
A
-
H
K
I
M
E
N
L
W
C
G
A
R
-
M
--------
L
S
S
D
E
-
L
A
A
--------------------------------
A
T
Q
G
L
V
Q
-
E
S
P
L
L
S
V
-----
N
Y
--------
P
I
G
L
I
H
P
T
T
K
E
N
I
-----
L
S
T
Q
L
L
------
E
K
I
A
Q
S
G
--
L
S
H
N
--------
E
V
F
L
V
N
T
G
D
H
W
L
L
C
L
-
F
Y
K
L
A
E
K
I
K
C
L
I
F
N
--
T
Y
Y
---------------------
D
L
N
E
N
T
K
Q
E
---
I
I
E
A
A
K
I
A
G
I
S
E
S
D
E
V
N
-----
F
I
E
M
N
L
Q
N
-------------------
N
V
P
N
G
C
G
L
F
C
Y
H
T
--
I
Q
L
L
---
S
N
A
G
--------------------------------
Q
N
-
D
P
A
T
T
L
R
E
F
A
E
N
F
L
T
---
L
-
S
-------------------------------
V
E
E
Q
A
----------
L
F
N
------
T
----
Q
T
R
R
Q
I
Y
----
E
Y
S
------------------
L
Q
---------------------------------------------
1
PsiBlast_PDB
47.67
24%
30
- C6 -
-
4ZS8
2
DASR_STRCO
A:
[29-154]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
K
H
L
L
D
M
---
T
R
T
Q
T
P
G
T
P
V
P
P
E
R
T
L
A
-----
A
E
F
D
T
S
R
T
-------------------
T
V
R
------
Q
A
L
Q
--
E
L
V
V
---
E
G
R
L
E
R
I
QG
K
G
T
F
V
A
------------
K
P
K
----
V
S
Q
A
-
L
Q
L
T
S
Y
T
E
D
M
R
A
Q
G
L
---
E
-
P
T
S
--
Q
---
L
L
D
---
I
-------
G
------
Y
I
T
A
D
D
R
----------
L
A
G
------
L
L
DIT
A
G
G
R
V
L
R
----
I
---------
E
R
L
R
M
A
N
G
E
P
M
-----------------------------------------------
4
PsiBlast_PDB
45.13
35%
2
* C6 *
-
1HL7
1
?
A:
[163-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
----
N
F
Y
N
L
D
E
N
L
---
G
S
-
R
--------
I
S
E
Q
A
-
V
T
G
--------------------------------
S
W
N
V
A
I
G
-
S
A
P
-
V
A
A
YAV
V
P
A
W
--------
I
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.70
35%
20
- C6 -
-
1HKH
-
?
A:
[163-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
----
N
F
Y
N
L
D
E
N
L
---
G
S
-
R
--------
I
S
E
Q
A
-
V
T
G
--------------------------------
S
W
N
V
A
I
G
-
S
A
P
-
V
A
A
Y
AV
V
P
A
W
--------
I
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.74
31%
-2
- C2 -
-
3UBH
-
A:
[365-418]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------
D
D
H
----
F
A
V
D
-
S
N
G
I
I
V
N
N
--
K
Q
L
D
A
---
D
-
N
N
N
--
A
---
Y
Y
E
---
F
-------
I
------
V
T
A
K
D
K
G
----------
E
P
P
------
K
----
S
G
V
A
T
V
R
----
V
Y
T
--
K
N
-------------------------------------------------------------
78
Fugue
37.76
16%
-32
* C3 *
-
1YD0
1
UVRC_THEMA
A:
[1-89]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
--
E
K
I
R
--------
K
K
I
L
L
A
P
E
E
P
G
V
Y
I
F
-
K
N
K
----
G
V
P
I
Y
I
G
K
A
K
R
-----------------------
L
S
N
R
L
R
S
Y
---
L
N
P
Q
T
E
K
V
F
R
I
G
E
E
A
D
E
-----
L
E
T
I
V
V
M
N
------------------------------
E
R
--
E
A
F
I
---
L
E
A
N
L
I
K
-----
K
Y
R
------------
P
K
Y
----
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
31.59
40%
62
* C4 *
-
5FFJ
2
?
A:
[1013-1071]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
E
S
I
L
---
N
I
D
--
W
E
-----
N
I
S
------------
P
D
E
----
N
N
D
W
-
I
N
Q
R
D
Q
N
Y
L
N
Y
R
P
L
A
---
D
-
E
N
G
--
S
---
I
F
S
V
K
D
I
-------
G
------
I
V
T
N
R
D
A
-------------------------------------------------------------------------------------------------------
14
HHSearch
24.70
17%
-92
- C6 -
-
4XYD
-
?
B:
[6-30]
----------------------------------
T
T
S
M
A
R
N
I
F
Y
G
G
S
L
---------
F
F
I
L
I
F
V
--------------
G
--------
L
S
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
10.84
5%
48
- C6 -
-
4FAJ
1
?
A:
[424-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
A
G
E
F
L
Q
---
G
-
Q
L
Q
--
D
S
L
E
G
L
K
---
V
-------
T
------
V
T
P
I
----------------------------------------------------------------------------------------------------------
72
HHSearch
5.86
0%
181
- C4 -
-
2NC8
-
LPPM_MYCTU
A:
[12-27]
----------------------------------------------
G
R
---------
E
N
L
Y
F
Q
G
--------------
H
--------
M
L
R
V
R
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
4.67
13%
136
- C6 -
-
2AP3
-
?
A:
[3-22]
---------------------------------------------------------
M
G
I
Q
R
P
T
--------------
S
--------
T
T
T
D
K
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------