@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZ57: (2017-12-16 )
MMNLSKVCKGVRQLKKYGPFLAIFFIALAFLMPHLFTHKLILGADAPFHYNRFYDAAQQIKYGDFHYFPSLYGFQQSGRIVNAVYGPFFAYLQGLIVLLAGSWFHYQILSNFILYLISGFSMLILLRYVNVRNWVSVPVAVLFMSTYSIQYWSINQGFTSWGTCFYPLCMIPIADFVLHKKFPVIKVAVSVGLMTQIHLLSSIMLALMYIPFYLYYFFNQTEKGKALLQLIKSVLLYFVLTANIWAGLAIVYSGNKILPPFVNREMSQKAIDLDGSYWLHYPKAFPILILSGFLLFIFFQQKNTLFQKIVLYTSLVFFFLSTSLIPWTTLIEKNVPFISLIQFPFRFFVPFTLLLLLYLALSLNQWSEQKWFRLLSIFGILIFSAQTIQNLYQHLEKWENETFVSRHTYLFDTPEEARKTFFSKDMSTSLFVFQKTTPDYLPIYKETKDNKYDRYNEEILENETTFIKTHPGGLLTIKWKNTGDKTVHIPVIVYDRTVLQQNGKTLTDYEVTDIGTPIVKQQKGINELTLHYQTPIYFYFILSLTLIGWFTLLCLFIYHRYKLLRA
Atome Classification :
(20 SA)
--------------------------.........10..------....-----..20.------..--------.---..---..-----30....-----------....40........50.--..--.....60....---....70-........-80--------------.........90.......-.100----.-.......---110-------..-......---120.......130...---....140........-150..-.-.-.-----------------..160.......170....-...180-----------........-.190.......200......-.210.......--------..220..----.....230...--------....240....--...250.-------......----260.......270.......280-........290.---------......-300.......310.......320....--------..-----.330.......340-..-......---------.350----........360........-.370..----.....380.......390.--......400........410--.........420-----.-..---.....430.-----------......440.......450-........-.460---........470..--------.--....480-----.......490-........500---...--------------------------------....510--...-....520.......530--........540...-....550.......560---.....-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------MM
N
L
S
K
V
C
K
G
V
R
Q
------
L
K
KY-----G
P
F
L
A
------
I
F
--------
F
---
I
A
---
L
A
-----
F
L
M
P
H
L
-----------
F
T
H
K
L
I
LGADAP
F
H
Y
N
R
--
F
Y
--
D
A
A
Q
QIKYGDF---HYF
P
S
L
-YGFQQSGR-
I
---------------
V
N
A
V
Y
G
P
F
F
A
Y
L
Q
G
L
I
V
L
-LAG-----S-
W
F
H
Y
Q
I
L
---
S
N
--------
F
I
-
L
Y
L
I
S
G
---
F
S
M
L
I
L
L
R
Y
V
N
V
R
N
W
V
---
S
V
P
V
A
V
-
L
F
M
S
T
Y
S
I
-
Q
Y
W
S
I-N-Q-G-----------------FTSWGTC
F
Y
P
L
C
M
I
P
I
A
D
F
-
V
L
HK-------------KF
P
V
I
K
V
A
-
V
S
V
G
L
M
T
Q
I
H
L
L
S
S
I
M
L
A
L
M
-
Y
I
--
P
F
Y
L
Y
Y
F
--------FNQTE
K
G
----
K
A
L
L
Q
L
I
K
S
V
L
--------
L
Y
F
V
L
T
A
N
IWA--
G
L
A
I
V
YS-------GNKILP----PF
V
N
R
E
MSQ
K
A
IDLDG
S
Y
W
L
HY--PK
A
F
P
I
L
I
L
S
G
F
---------
L
L
F
I
FF-QQK
N
T
L
F
Q
K
I
V
L
Y
T
S
L
V
F
F
F
L
STSLI
P
--------
W
T
-----
T
L
I
EKNV
P
F
I
S
L
---
I
Q
-
F
P
F
R
F
F
---------
V
P
F
-----
T
L
L
L
L
L
Y
L
A
--
L
S
LNQW
S
E
-
Q
K
W
F
R
L
----
L
S
I
F
G
I
L
I
F
S
A
Q
T
I
Q
N
L
Y
Q
--
H
L
E
K
WENE-
T
F
VSRH
T
Y
L
----FD
T
P
E
E
A
R
K
T
F
------
F
-SK---DMS
T
S
L
F
V
F
-----------QKTTPDYLPIYKETKDN---KYD
R
Y
N
E
E
-
I
LE----NE
T
T
F
I
K
THPG
G
L
--------
L
--
T
I
K
WKNT-----GD
K
T
V
H
I
P
V
--
I
V
Y
D
R
T
V
L
Q
QN---GKT--------------------------------L
T
D
Y
EVT--DIG-T
P
I
V
K
Q
QKGI
N
E
L
T
L
H
---YQT
P
I
Y
F
Y
F
I
L
S
L
T
-
L
I
G
W
F
T
L
L
C
L
F
I
Y
H
R
Y
----
K
L
LRA-----
20
Fugue
68.95
17%
-36
- C7 -
-
4WBD
3
BSHC_BACSU
A:
[2-541]
--------------------------
H
M
Q
L
T
E
L
-----
S
------
I
K
N
Q
-----
N
V
F
V
Q
------
H
Y
--------
I
D
GK
E
E
---
M
S
-----
S
F
F
D
Y
S
-----------
I
H
H
K
D
M
W
R
E
R
L
E
D
L
S
S
R
--
F
F
--
A
R
E
E
L
A
A
Y
--
L
---
T
S
Y
H
N
K
-
F
G
S
S
A
M
Q
S
-
A
---------------
I
E
K
L
K
D
P
------
S
S
A
A
V
-
V
G
G
-----
Q
---
Q
A
G
L
L
---
T
G
--------
P
L
-
Y
T
I
H
K
I
---
I
S
I
I
V
L
A
K
Q
Q
E
K
E
L
Q
V
---
P
V
-
I
P
I
-
F
W
V
A
G
E
D
H
-
D
L
D
E
I
-
N
-
F
-
V
-----------------
H
T
S
E
E
N
G
-------
P
V
K
K
K
-
L
P
Q
S
-------------
Y
W
K
K
S
S
A
A
S
T
S
L
D
Q
E
K
C
A
A
W
I
D
D
V
F
A
A
----------------------
F
E
E
T
D
H
T
----
N
T
L
L
D
N
V
K
R
C
L
R
E
SVT
F
T
D
F
F
E
L
L
I
A
D
L
F
Q
EE
G
L
V
L
L
N
S
-------
G
D
P
G
I
K
----
K
L
-
E
T
A
M
F
Q
K
I
L
R
E
N
D
E
L
A
R
A
V
--
S
D
Q
Q
A
F
M
R
Q
A
G
Y
K
P
I
IESGKE
Q
A
N
L
F
Y
-
E
Y
E
D
---
E
R
F
L
I
E
K
D
N
G
R
F
V
I
K
E
L
D
L
G
--------
W
T
R
D
E
L
H
T
H
M
E
E
H
P
E
R
F
S
N
---
N
V
-
V
T
R
P
L
M
---------
Q
E
F
-----
L
I
P
T
L
A
F
I
A
G
P
G
E
I
N
Y
W
G
E
L
K
Q
A
F
A
V
----
M
G
F
K
M
P
P
V
M
P
R
L
N
I
T
I
L
E
R
--
H
I
E
K
K
L
A
E
-
R
N
I
S
L
Q
D
A
I
----
E
R
G
T
E
N
Q
R
E
T
Y
------
F
-
E
R
Q
IP
E
E
F
T
A
V
M
D
Q
-----------
A
K
S
Q
I
E
A
I
H
K
T
V
R
Q
E
A
L
---
K
V
D
Q
S
L
E
P
-
L
L
L
----
K
N
A
A
F
I
Q
D
Q
L
Q
F
L
--------
E
--
R
T
V
M
K
R
I
-----
E
E
K
------------------
E
---
G
Y
V
--------------------------------
L
K
D
Y
E
R
I
--
Q
N
S
I
K
P
L
L
A
P
Q
E
R
I
----------
W
N
I
M
Y
Y
L
N
R
Y
G
P
K
-
F
F
T
T
F
K
N
L
P
F
S
F
Q
N
Q
H
----
Q
V
V
K
L
-----
19
Fugue
68.35
20%
-
- C7 -
-
4XR7
-
PAN3_YEAST
B:
[225-680]
---------------------------------------------------------------------------------------------
M
H
S
L
-----------
L
Q
Y
R
---
S
A
D
Q
L
F
I
P
N
N
--
I
R
--
E
D
L
T
K
K
N
L
S
I
L
---
Q
V
F
P
S
-------
S
G
K
-
V
---------------
I
P
S
I
V
Q
D
Y
F
----
N
L
V
P
L
N
F
N
N
-----
K
-
T
T
L
F
K
V
F
---
S
N
--------
Y
-------
D
---
G
K
A
Y
V
L
K
R
L
P
N
I
D
K
------------------
S
M
-
N
P
N
K
I
-
S
-
K
-
I
-----------------
Y
Q
I
W
S
K
I
N
C
T
-
N
L
I
K
F
R
D
I
-
F
Q
T
T
-------------
K
F
G
D
L
-----
S
I
C
L
V
F
D
Y
Y
P
N
S
---------
L
--
S
L
Y
D
Y
H
F
--------
V
N
F
P
K
F
P
----------
I
T
N
N
Y
--------
L
W
I
Y
L
V
Q
L
T
N
V
--
I
N
S
I
H
S
Q
-------
N
L
S
I
G
N
----
T
L
N
W
R
K
V
L
I
T
G
D
P
--
G
R
I
K
L
S
H
-----------
C
N
F
---------
M
D
L
L
F
N
-
D
D
T
D
T
V
V
S
S
----------------------------------------
T
I
E
G
Q
---
Q
Q
-
L
D
Y
K
Y
L
---------
G
E
L
-----
L
F
N
L
S
I
N
I
E
--
N
S
N
N
N
-
T
A
-
P
K
E
Y
R
L
----
E
E
I
------
T
P
Q
S
I
D
D
M
R
Q
--
I
-----
D
D
-
K
F
K
D
V
L
K
Y
L
----
I
S
D
N
G
D
S
K
K
S
I
HD----
L
-
T
S
---
H
F
Y
D
K
M
F
M
V
-----------
L
E
S
S
Q
T
Y
T
E
Y
M
E
S
V
L
S
R
---
E
L
E
N
G
R
L
F
-
R
L
V
----
N
K
L
N
C
I
F
G
R
I
E
S
R
--------
I
--
D
I
N
W
S
E
S
-----
G
T
K
---
F
P
I
--
I
L
F
Y
D
Y
V
F
H
Q
V
DSN
G
K
P
--------------------------------
I
M
D
--
L
T
--
H
V
L
-
R
C
L
N
K
L
D
A
G
I
Q
E
-
K
L
M
---
L
V
T
P
D
E
----
L
N
C
I
-
I
I
S
Y
K
E
L
K
D
L
I
E
S
T
F
R
----
S
I
T
Q
H
-----
21
Fugue
67.69
17%
-24
- C7 -
-
3WOL
7
DAPB2_PSEMX
A:
[1-696]
--------------------GEGMWV
P
Q
Q
L
P
E
I
A
G
P
L
K
K
A
GLKLS
P
Q
Q
I
S
DLTG
D
P
M
G
A
------
V
V
ALGG
C
T
A
S
F
---
V
S
PNG
L
V
-----
V
T
N
H
H
C
-----------
A
Y
G
A
I
Q
L
N
S
T
A
E
N
N
L
I
K
N
G
F
N
A
P
T
T
A
D
E
V
S
A
G
P
N
---
A
R
V
F
V
L
-
D
E
I
T
D
V
T
K
-
D
---------------
A
K
A
A
I
A
A
--
A
G
D
D
A
L
A
R
T
-
K
A
L
-----
E
-
A
F
E
K
K
L
I
---
A
D
C
E
AEAG
F
R
C
R
-
L
Y
S
F
S
G
GN
T
Y
R
L
F
K
N
L
E
I
K
D
V
R
L
A
Y
---
A
P
P
G
S
V
G
K
F
G
G
D
I
D
N
-
W
M
W
P
R
-
H
-
T
-
G
D
F
A
F
Y
R
A
Y
V
G
KDG
K
P
A
A
F
S
K
D
N
V
P
Y
Q
P
K
H
W
L
K
F
A
D
Q
-
P
L
G
A
-------------
G
-
D
F
V
M
V
A
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G
Y
P
G
S
T
N
R
Y
A
L
A
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D
N
T
A
Q
W
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Y
--
P
T
I
A
R
H
Y
--------
K
N
Q
I
A
M
V
----
E
A
A
G
K
Q
N
A
D
I
Q
--------
V
K
Y
A
A
T
M
A
G
W
N
--
N
T
S
K
N
Y
D
-------
G
Q
L
E
G
F
----
K
R
I
D
A
A
G
Q
K
L
R
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E
A
A
V
L
G
W
L
K
G
Q
G
A
K
G
Q
P
A
L
D
A
H
A
K
---------
L
L
D
L
L
E
-
Q
S
K
A
T
R
D
R
D
L
T
L
A
L
F
N
N
T
A
M
L
G
S
A
T
Q
L
--------
Y
R
-----
L
S
I
E
R
E
K
P
N
A
E
R
---
E
S
G
Y
Q
E
R
D
L
---------
P
A
I
-----
E
G
G
L
K
Q
L
E
R
--
R
Y
V
A
A
M
D
R
-
Q
L
Q
E
Y
W
----
L
N
E
Y
I
K
L
P
-
A
D
Q
R
V
A
A
V
D
A
--
W
L
G
G
N
D
A
A
-
A
V
K
R
A
L
D
R
L
A
G
TK
L
G
S
T
E
E
R
L
K
W
F
A
AD
R
K
A
F
-
E
A
---
S
N
D
P
A
I
Q
Y
A
-----------
V
A
V
M
P
T
L
L
K
L
E
Q
E
R
K
T
R
---
A
G
E
N
L
A
A
R
P
V
Y
L
----
Q
A
L
A
D
Y
K
K
S
Q
G
E
F
V
Y
P
DANL
S
L
--
R
I
T
F
G
N
V
M
G
Y
A
P
K
D
G
M
E
Y
T
P
F
--
T
T
L
E
G
V
V
A
K
E
T
---
G
Q
D
PFDSP
K
A
L
L
D
A
V
A
A
KRYGGLEDKRIGSVPV
N
Y
L
S
D
L
D
I
T
GG
N
S
G
-
S
P
V
L
D
A
H
G
K
L
V
G
L
A
F
D
GNW
E
S
V
S
S
N
W
V
F
D
P
K
M
T
R
M
I
A
V
D
G
R
Y
L
R
W
I
M
Q
E
V
YPA
P
Q
L
L
K
E
M
NV--
27
Fugue
64.72
16%
-49
* C5 *
-
5C37
2
FAS_HUMAN
A:
[1-655]
E
Q
Q
V
P
I
L
E
K
F
C
FTPHTEEGCLSER
A
A
L
Q
E
E
L
Q
L
C
K
G
L
V
Q
------
A
L
Q
T
-----
K
A
Q
I
P
------
R
D
--------
P
---
S
Q
---
Q
E
-----
L
P
R
L
L
S
-----------
A
A
C
R
L
Q
L
N
G
N
L
Q
L
E
L
A
Q
--
V
L
--
A
Q
E
R
P
K
L
P
E
D
----
P
L
L
S
G
L
-
L
D
S
P
A
L
K
A
-
C
---------------
L
D
T
A
V
E
N
M
P
S
L
K
M
K
V
V
E
V
-
L
A
G
-----
H
-
G
H
L
Y
S
R
I
---
P
G
--------
L
L
S
P
H
P
L
L
Q
---
L
S
Y
T
A
T
D
R
H
---
P
Q
A
L
---
E
A
A
Q
A
E
-
L
Q
Q
H
D
V
A
Q
-
G
Q
W
D
P
-
A
-
D
P
A
-----------------
P
S
A
L
G
S
A
D
L
L
V
C
N
C
A
V
A
A
L
G
D
P
A
S
-------------
A
L
S
N
M
V
A
A
-
L
R
E
G
G
F
L
L
L
H
T
L
------
L
R
-
G
H
--
P
L
G
D
I
V
A
--------
F
L
T
S
G
Q
G
ILS
Q
D
A
W
E
S
L
F
S
R
V
S
--------
L
R
L
V
G
L
K
K
S
F
Y
--
G
S
T
L
F
L
C
R
R
P
T
PQ
D
S
P
I
F
L
P
VDDT
S
F
R
W
V
E
S
L
K
G
I
L
A
D
E
D
S
S
R
P
V
W
--
L
K
A
I
N
C
A
T
S
G
V
V
---------
G
L
V
N
C
L
R
R
E
P
G
G
N
R
L
R
C
V
L
L
S
N
L
----
S
S
T
S
H
V
P
E
VDPGS
A
E
L
Q
-----
K
V
L
Q
G
D
L
V
M
N
V
Y
R
DG
A
W
-
G
A
F
R
H
F
LLEEDS
K
T
G
C
P
A
-----
H
K
S
Y
I
I
A
G
G
--
L
G
G
F
G
L
E
L
-
A
Q
W
L
I
Q
----
R
G
V
Q
K
L
V
L
T
S
R
S
G
I
R
T
G
Y
Q
A
K
Q
V
R
R
W
R
R
Q
G
V
Q
V
Q
V
S
T
S
N
----
I
S
S
L
E
G
A
R
G
L
I
------
A
E
A
A
---
Q
L
G
P
V
G
G
V
F
N
L
A
V
V
L
RDGLL
E
N
Q
T
P
E
F
F
Q
D
V
C
K
P
K
Y
S
G
T
L
N
L
D
R
V
T
R
E
-
A
C
P
----
E
L
D
Y
F
V
V
F
S
S
V
S
C
--------
G
R
G
N
A
G
Q
S
N
Y
-----
G
F
A
N
S
A
M
E
R
--
I
C
E
K
R
R
H
E
G
L
P
---
G
L
A
--------------------------------
V
Q
W
G
A
I
G
--
D
V
G
---
I
L
V
E
T
M
S
T
N
D
T
I
V
S
---
G
T
L
P
--------
Q
R
-
M
A
S
C
L
E
V
L
D
L
F
L
N
Q
P
H
----
M
V
L
S
S
F
V
L
A
E
25
Fugue
56.68
20%
-108
- C4 -
-
4QUV
1
ERG_META2
A:
[23-427]
---------------------------------
F
S
W
L
V
L
------
M
I
A
L
-----
P
P
L
V
Y
------
Y
L
--------
W
---
I
C
---
V
T
-----
Y
----------------
Y
Q
G
E
L
V
F
T
S
D
A
A
-
A
W
R
R
--
F
W
--
S
H
V
A
P
P
T
-------
W
H
A
A
G
L
-
Y
A
A
W
F
L
G
Q
-
A
---------------
A
L
Q
V
W
A
P
G
-
P
T
V
Q
G
M
K
-
L
-
P
D
G
-----
S
-
R
L
D
Y
R
M
-----------------------------------------------
N
G
I
F
-
S
F
L
F
T
L
A
V
-
V
F
G
L
V
-
T
-
M
-
G
-----------------
W
L
D
------------------------------------
A
T
V
L
Y
D
-
Q
L
G
P
L
L
T
V
V
N
I
F
T
F
V
F
A
G
F
L
-
Y
F
W
G
P
F
Y
D
Y
F
M
--------------
G
----
T
A
L
N
P
R
I
G
S
L
D
--------
L
K
L
F
C
E
A
R
P
-------------------
G
M
I
F
W
----
L
L
M
N
L
S
M
A
A
K
Q
Y
E
L
H
G
T
--------
V
T
V
P
M
L
L
V
V
G
F
---------
Q
S
F
Y
L
I
-
D
Y
F
I
---------------
H
E
E
A
V
L
T
T
--------
W
D
-----
I
K
H
E
K
---------------
F
G
W
M
---------
L
C
W
-----
G
D
L
V
W
L
P
F
T
--
Y
T
-------------------------
L
Q
A
Q
Y
L
V
H
H
T
H
--
D
L
P
V
W
G
I
I
-
A
I
V
A
L
N
L
A
G
----
Y
A
I
F
R
G
A
N
I
Q
K
------
H
-
H
F
---
R
R
D
P
N
R
I
V
W
-----------
G
K
P
A
K
-----
Y
I
K
T
K
Q
G
---------
S
L
-
L
L
T
SGWW
G
I
A
R
H
M
N
Y
F
G
D
L
M
--------
I
--
A
L
S
W
C
L
P
-----
A
A
F
G
S
P
I
P
Y
F
H
I
V
Y
F
T
I
L
L
L
H
R
---
E
K
R
--------------------------------
D
D
A
M
C
L
A
--
K
Y
G
-
E
D
W
L
Q
Y
R
K
K
V
P
---
W
R
---
I
V
P
K
I
Y
---------------------------------------
28
Fugue
50.82
14%
-28
- C5 -
-
1QNI
-
?
A:
[10-581]
------------------------------
A
H
V
A
P
G
--
E
------
L
D
E
Y
-----
Y
G
F
W
S
GGHQG
E
V
R
--------
V
---
L
G
---
V
P
SMREL
M
R
I
P
V
F
NVDSATGWGIT
N
E
S
K
E
I
L
G
G
D
Q
Q
Y
L
N
G
D
--
C
H
--
H
P
H
I
S
M
T
D
G
R
Y
DGK
Y
L
F
I
N
D
-
K
A
N
T
R
V
A
R
-
I
RLDIMKTD
K
I
T
H
I
P
N
V
Q
A
I
H
G
L
R
L
Q
K
V
P
K
T
N
Y
V
-
F
C
N
-----
A
-
E
F
V
I
P
Q
P
NDG
T
D
--------
F
S
-
L
D
N
S
Y
T
---
M
F
T
A
I
D
A
E
T
M
D
V
A
W
Q
V
---
I
V
D
G
N
L
-
D
N
T
D
A
D
Y
T
-
G
K
Y
A
T
-
S
-
T
-
C
-----------------
Y
N
S
E
R
A
V
D
L
A
G
T
M
R
N
D
R
D
W
-
V
V
V
F
-------------
N
V
E
R
I
A
A
A
-
V
K
A
G
N
F
K
T
I
G
D
S
K
V
P
V
V
D
G
R
-
G
E
--
S
E
F
T
R
Y
I
P
V
P
K
NP
H
G
L
N
T
S
P
D
G
----
K
-------------------
Y
F
I
A
N
G
K
L
-
S
--
P
T
V
S
V
I
A
-------
I
D
K
L
D
D
----
L
F
E
D
K
I
E
L
R
D
T
I
V
A
E
---------------
P
E
L
G
L
G
---------
P
L
H
T
T
F
-
D
G
R
G
N
A
Y
T
T
L
F
I
D
S
Q
V
C
K
W
N
I
A
D
A
I
K
H
--------
Y
N
-----
G
--
D
R
V
N
Y
I
R
Q
K
---
L
D
-
V
Q
Y
Q
P
G
---------
H
N
H
A
SLTE
S
R
D
A
D
G
K
W
L
--
V
V
L
S
K
F
S
K
-
D
R
F
L
P
V
GP
L
H
P
E
N
D
Q
L
I
D
I
S
G
E
E
M
K
L
V
H
D
--
G
P
T
Y
A
E
P
H
-
D
C
I
L
V
R
R
D
Q
----
I
K
T
K
K
----
I
Y
------
E
-
R
N
---
D
P
Y
F
A
S
C
R
A
-----------
Q
A
E
K
D
G
V
----
T
L
E
S
D
N
---
K
V
I
R
D
G
N
K
-
V
R
V
----
Y
M
T
S
V
A
P
Q
Y
G
M
T
D
--------
F
--
K
V
K
---
E
-----
G
D
-
E
V
T
V
Y
I
--
T
N
L
D
M
V
E
D
V
T
H
---
G
F
C
--------------------------------
M
V
N
H
G
V
S
--
M
E
I
-
S
P
-----
Q
Q
T
A
S
V
T
F
T
---
A
G
K
P
G
V
Y
W
Y
Y
C
N
-----
W
F
C
H
A
L
H
M
E
M
V
G
R
M
----
L
V
E
A
A
-----
10
HHSearch
43.37
15%
-169
- C8 -
-
3WAJ
-
?
A:
[44-278]
------------------------------------------------------------------------------------------------------------------
G
G
N
D
P
W
Y
Y
Y
R
L
--
I
E
--
N
T
I
H
---
N
F
P
H
---
R
I
W
F
D
P
-
F
T
Y
Y
P
Y
G
S
-
Y
---------------
T
--
H
F
G
P
F
L
V
Y
L
G
S
I
A
G
I
-
I
F
S
ATSG
E
S
L
R
A
V
L
A
F
----
I
P
--------
A
I
-
G
G
V
L
A
I
---
L
P
V
Y
L
L
T
R
E
V
F
-
D
K
R
A
---
A
V
I
A
A
F
-
L
I
A
I
V
P
G
Q
F
L
Q
R
S
I
L
G
F
N
-
D
-----------------
H
H
I
W
E
A
F
W
Q
V
S
A
L
G
T
F
L
L
A
-
Y
N
R
W
KGHDLT
A
R
Q
----
M
A
Y
P
V
I
A
G
-
I
T
I
G
L
Y
V
L
S
W
G
A
G
F
I
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
41.07
15%
-159
- C8 -
-
3WAK
-
?
A:
[44-221]
------------------------------------------------------------------------------------------------------------------
G
G
N
D
P
W
Y
Y
Y
R
L
--
I
E
--
N
T
I
H
---
N
F
P
H
---
R
I
W
F
D
P
-
F
T
Y
Y
P
Y
G
S
-
Y
---------------
T
--
H
F
G
P
F
L
V
Y
L
G
S
I
A
G
I
-
I
F
S
ATSG
E
S
L
R
A
V
L
A
F
----
I
P
--------
A
I
-
G
G
V
L
A
I
---
L
P
V
Y
L
L
T
R
E
V
F
-
D
K
R
A
---
A
V
I
A
A
F
-
L
I
A
I
V
P
G
Q
F
L
Q
R
S
I
L
G
F
N
-
D
-----------------
H
H
I
W
E
A
F
W
Q
V
S
A
L
G
T
F
L
L
A
-
Y
N
R
W
KGHDLSHNLT
A
R
Q
M
A
Y
P
V
I
A
G
-
I
T
I
G
L
Y
V
L
S
W
G
A
G
F
I
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
39.20
8%
-200
- C8 -
-
5EZM
8
?
A:
[86-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
K
P
P
F
H
M
W
V
T
V
V
G
Y
E
-
L
F
G
L----
G
-
E
W
Q
A
R
L
----
A
V
--------
A
L
-
S
G
L
L
G
I
---
G
V
S
M
M
A
A
R
R
W
F
G
A
R
-
A
---
A
A
F
T
G
L
-
A
L
L
A
A
P
M
W
-
S
V
A
A
H
-
F
-
N
-
T
-----------------
L
D
M
T
L
A
G
V
M
S
C
V
L
A
F
M
L
M
G
-
Q
H
P
D
AS
V
A
A
R
-------
R
G
W
M
V
A
C
W
-
A
A
M
G
V
A
I
L
T
K
G
L
V
G
I
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
37.59
8%
-194
* C8 *
-
5F15
8
?
A:
[86-222]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
K
P
P
F
H
M
W
V
T
V
V
G
Y
E
-
L
F
G
L----
G
-
E
W
Q
A
R
L
----
A
V
--------
A
L
-
S
G
L
L
G
I
---
G
V
S
M
M
A
A
R
R
W
F
G
A
R
-
A
---
A
A
F
T
G
L
-
A
L
L
A
A
P
M
W
-
S
V
A
A
H
-
F
-
N
-
T
-----------------
L
D
M
T
L
A
G
V
M
S
C
V
L
A
F
M
L
M
G
-
Q
H
P
D
AS
V
A
A
R
-------
R
G
W
M
V
A
C
W
-
A
A
M
G
V
A
I
L
T
K
G
L
V
G
I
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
35.56
9%
-164
- C8 -
-
3RCE
-
PGLB_CAMLR
A:
[53-228]
------------------------------------------------------------------------------------------------------------------
T
T
N
D
G
Y
A
F
A
E
G
--
A
R
--
D
M
I
A
---
G
F
H
Q
---
P
N
------
D
L
------------------------
S
Y
F
G
S
S
L
S
T
L
T
Y
W
L
Y
S
-
I
L
P
F----
S
F
E
S
I
I
L
Y
----
M
S
--------
T
F
-
F
A
S
L
I
V
---
V
P
I
I
L
I
A
R
E
Y
K
L
-
T
T
Y
---
G
F
I
A
A
L
-
L
G
S
I
A
N
S
Y
-
Y
N
R
T
M
-
S
G
Y
Y
D
-----------------
T
D
M
L
V
L
V
L
P
M
L
I
L
L
T
F
I
R
L
-
T
I
N
K
D------------
I
F
T
L
L
L
S
P
-
I
F
I
M
I
Y
L
W
W
Y
P
S
S
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
31.46
17%
-79
- C6 -
-
5FU5
-
?
A:
[72-100]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
T
A
K
V
D
---
G
N
K
--------------------------------
V
T
----
A
--
S
N
G
-
I
I
T
V
D
L
A
Q
G
A
H
T
I
---------------------------------------------------
15
HHSearch
29.10
6%
-53
- C1 -
-
2BGP
-
?
A:
[90-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
T
L
S
A
G
N
H
S
F
G
V
R
---
V
G
-------------------------------------------
8
PsiBlast_PDB
28.53
29%
-159
- C9 -
-
5C1M
3
OPRM_MOUSE
A:
[134-204]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
-
M
F
M
A
T
T
K
Y
-
R
Q
G
S
I
-
D
-
C
-
T
-----------------
L
T
F
S
H
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
-
I
F
A
F
-------------
I
M
P
V
L
I
I
T
-
V
C
Y
G
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
27.89
22%
-40
- C6 -
-
4AZT
1
WBDD_ECOLX
A:
[228-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
F
N
Q
--
P
F
Q
H
W
Q
N
--------------------
R
S
R
R
Y
F
------
F
-
G
E
---
D
Y
V
C
K
F
F
Y
Y
-----------
D
--
M
P
H
G
I
L
T
A
E
E
S
Q
R
N
---
K
Y
E
-------
L
H
----
N
E
I
K
F
L
T
Q
P
P
A
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_CBE
26.84
35%
-70
* C10 *
-
3JZL
1
?
B:
[27-89]
----------------------------------------------------------------------------------------------------------------------
A
E
F
N
Q
A
K
--
V
L
--
D
A
F
Q
E
N
K
V
S
D
F
---
H
F
H
P
S
T
G
Y
G
Y
D
D
E
G
R
D
T
---------------
L
E
R
V
Y
A
T
V
F
K
T
E
A
A
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
26.76
35%
-69
- C10 -
-
3JZL
1
?
A:
[27-79]
----------------------------------------------------------------------------------------------------------------------
A
E
F
N
Q
A
K
--
V
L
--
D
A
F
Q
E
N
K
V
S
D
F
---
H
F
H
P
S
T
G
Y
G
Y
D
D
E
G
R
D
T
---------------
L
E
R
V
Y
A
T
V
F
K
T
E
A
A
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
26.50
29%
-133
* C9 *
-
4DKL
3
ENLYS_BPT4 (first)
A:
[134-204]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
-
M
F
M
A
T
T
K
Y
-
R
Q
G
S
I
-
D
-
C
-
T
-----------------
L
T
F
S
H
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
-
I
F
A
F
-------------
I
M
P
V
L
I
I
T
-
V
C
Y
G
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
26.01
35%
-65
- C10 -
-
3FD0
2
?
A:
[27-79]
----------------------------------------------------------------------------------------------------------------------
A
E
F
N
Q
A
K
--
V
L
--
D
A
F
Q
E
N
K
V
S
D
F
---
H
F
N
P
S
T
G
Y
G
Y
D
D
E
G
R
D
T
---------------
L
E
R
V
Y
A
S
V
F
K
T
E
A
A
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
24.18
22%
-5
- C6 -
-
4AZV
-
WBDD_ECOLX
A:
[228-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
F
N
Q
--
P
F
Q
H
W
Q
N
Q
-
P
Y
----------------
R
S
R
R
Y
F
------
F
-
G
E
---
D
Y
V
C
K
F
F
Y
Y
-----------
D
--
M
P
H
G
I
L
T
A
E
E
S
Q
R
N
---
K
Y
E
-------
L
H
----
N
E
I
K
F
L
T
Q
P
P
A
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------