@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZ74: (2017-12-16 )
MMDIHKFEVFLDLAETMNFTKTADRQFTTQGNISKQILSLETELDVKLFERAHRKIELTEAGSLLLPYVKNVVEQYHAMQEVLETYTKDNNLSLNILTIPTMINYKGFSKITEFLKRHPEFTVQLKEVESVELTYNDANEHSDTIHFARSFQAPPSSIEWLPTETDDFVAVLPKNHPLASKKKLDLSELKKENFLLLGPTTNLYQPVLDLCREAGFEPKISYKGARIDLIINMIANDMGIAIVMEKTVKNLLKENTVILPISPTTESYLAFTRKVGEHSLASDTFWEYLNQEEN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.---.......80........90.----.......100.......110.-......120.......130.......140----.....--...150.---......160...-....170......--.--180.........190....--.--..200-........210--..--.---..-...220.......230.......240.----......250-..-......----260-.--.---.....270.---......280.......290..----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMD
I
H
K
F
E
V
F
L
D
L
A
E
TMNFTKTAD
R
Q
FTTQGN
I
S
K
Q
I
L
S
LETEL
D
V
K
L
F
E
R
AH
R
K
I
E
LTEAG
S
L
L
L
P
Y
V
K
N
V
---
V
E
Q
Y
H
A
M
Q
E
V
L
E
T
YTKDN
N
L
----
S
L
N
I
L
TI
P
T
MINYK
G
F
S
K
I
T
E
-
F
L
K
RHP
E
F
T
V
Q
L
K
E
V
E
S
V
E
L
T
YNDANEH-----S
D
T
I
H
--
F
A
R
SFQA---PPSS
I
E
WLPTET-D
D
F
V
A
VLPKNHPL--A--S--KKKL
D
L
S
E
LKKE
N
F
L
L
--L--GPTT--
N
L
Y
Q
P
V
L
D
L
C
---
R
E--A---GF-EP
K
I
SYKG
A
R
I
D
L
I
I
N
M
I
ANDM
G
I
A
I
V
----
M
E
K
T
V
K
N
-
L
-
L
K-EN
T
V
I
L
----
P
IS-P--T---
T
E
S
Y
L
A
F
T
R
---
K
VGEHSL
A
S
D
T
F
W
E
Y
L
NQEEN----
49
Fugue
84.00
21%
-68
- C2 -
-
1IZ1
-
?
A:
[1-292]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
----
E
L
S
V
A
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
-
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
-----
I
H
-
V
G
--
F
S
R
F
F
P
R
---
H
P
G
-
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
--
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
--
F
PR
G
G
R
P
--
S
F
A
D
E
V
I
G
L
F
---
K
H
--
A
---
G
I
-
E
P
R
I
A
R
V
V
E
D
A
T
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
----
P
-
A
S
V
A
A
-
I
-
R
W
-
P
D
I
A
F
A
----
R
I
V
G
T
--
R
---
V
K
V
P
I
S
C
I
F
---
R
K
E
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
-----
32
HHSearch
80.69
22%
-46
- C2 -
-
1IZ1
-
?
B:
[1-291]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
----
E
L
S
V
A
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
-
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
--------
T
I
H
--
V
G
F
S
R
F
F
P--
R
H
P
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
--
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
--
F
--
P
R
G
G
RP
S
F
A
D
E
V
I
G
L
F
---
K
H
--
A
---
G
I
-
E
P
R
I
A
R
V
V
E
D
A
T
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
----
P
A
S
V
A
A
I
-
R
--
W
-
P
D
I
A
F
A
----
R
I
V
-
G
--
T
RVK
V
P
I
S
C
I
F
-
R
---
K
E
K
-
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
------
3
PsiBlast_PDB
79.78
22%
-136
- C2 -
-
4X6G
4
?
A:
[7-249]
-
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
S
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
---
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
----
P
L
K
V
G
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
-
L
H
R
V
A
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
-----
L
D
A
I
I
--
I
A
L
P
F
Q
E
-----
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
P
W
--
T
--
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
--
L
--
G
E
G
H
--
D
F
R
D
Q
V
L
E
A
C
P
T
V
R
K
--
G
---
D
E
-
N
K
H
T
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
---------------------------------------------------------------------------
36
HHSearch
75.92
19%
-62
- C2 -
-
4X6G
4
?
A:
[6-302]
H
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
S
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
---
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
----
P
L
K
V
G
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
-
L
H
R
V
A
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
--------
E
L
D
--
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
P
W
--
T
--
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
--
L
--
G
E
G
H
--
D
F
R
D
Q
V
L
E
A
C
---
P
T
--
V
R
K
G
D
E
-
N
K
H
T
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
----
P
F
S
A
V
D
S
-
H
H
Y
A
P
G
V
I
E
V
R
----
P
F
S
-
A
--
P
V
P
F
R
T
V
A
I
A
W
-
R
---
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
------
37
HHSearch
74.81
19%
-61
- C2 -
-
4X6G
2
?
E:
[6-302]
H
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
-----
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
---
L
E
Q
A
Q
G
I
R
E
L
A
Q
A
G
K
N
Q
L
A
A
----
P
L
K
V
G
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
-
L
H
R
V
A
P
Q
M
P
L
Y
I
E
E
N
F
T
H
I
L
R
D
K
L
R
T
G
--------
E
L
D
--
A
I
I
I
A
L
P
F
--
Q
E
A
D
V
L
T
K
P
L
F
D
-
E
P
F
Y
V
L
M
P
A
D
H
P
W
--
T
--
A
--
K
A
S
I
D
S
E
L
L
N
D
K
S
L
L
L
--
L
--
G
E
G
H
--
D
F
R
D
Q
V
L
E
A
C
---
P
T
--
V
R
K
G
D
E
-
N
K
H
T
T
V
E
S
S
S
L
E
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
----
P
F
S
A
V
D
S
-
H
H
Y
A
P
G
V
I
E
V
R
----
P
F
S
-
A
--
P
V
P
F
R
T
V
A
I
A
W
-
R
---
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
------
28
HHSearch
73.90
17%
-58
- C2 -
-
3FXQ
6
TSAR_COMTE
A:
[1-294]
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
E
S
R
R
A
Q
E
E
I
G
Q
L
R
G
R
W
E
G
----
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
-
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
--------
T
L
D
--
F
A
L
T
A
A
H
KHD
I
D
T
D
L
E
A
Q
P
L
Y
V
-
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
--
N
--
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
F
--
S
--
S
A
P
R
--
G
P
G
A
I
I
R
N
A
F
---
A
R
--
Y
---
G
L
P
E
P
K
L
G
L
V
C
E
S
F
L
A
L
P
G
V
V
A
H
S
D
L
L
T
T
M
----
P
R
T
L
Y
E
R
N
A
-
F
K
-
D
Q
L
C
S
I
----
P
L
Q
-
D
--
A
L
P
N
P
T
I
Y
V
L
R
-
R
---
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
------
5
PsiBlast_PDB
68.03
24%
-41
- C2 -
-
3K1N
1
BENM_ACIAD
A:
[1-247]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
T
I
R
I
G
F
V
G
S
L
L
F
G
L
L
P
R
I
I
H
L
---------
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
-
E
A
L
K
E
G
-----
R
I
D
A
G
--
F
G
R
L
K
I
S
---
D
P
-
A
I
K
R
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
P
L
NQ
M
--
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
--
Y
P
S
S
P
K
P
--
N
F
S
T
H
V
M
N
I
F
---
S
D
--
H
---
G
L
-
E
P
T
K
I
N
E
V
R
E
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
----
P
A
S
T
-------------------------------------------------------------------
9
PsiBlast_PDB
67.83
26%
-64
- C2 -
-
1IZ1
-
?
A:
[1-220]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
----
E
L
S
V
A
Y
F
G
T
P
I
-
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
T
P
T
A
T
V
S
L
-----
T
H
M
T
K
D
E
Q
V
E
G
L
L
---
A
G
T
I
H
V
G
F
S
R
F
F
P
R
---
H
P
-
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
--
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
--
F
PR
G
G
R
P
--
S
F
A
D
E
V
I
G
L
F
---
K
H
--
A
---
G
I
-
E
P
R
I
A
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.06
24%
-39
- C2 -
-
3K1M
2
BENM_ACIAD
A:
[1-247]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
T
I
R
I
G
F
V
G
S
L
L
F
G
L
L
P
R
I
I
H
L
---------
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
-
E
A
L
K
E
G
-----
R
I
D
A
G
--
F
G
R
L
K
I
S
---
D
P
-
A
I
K
H
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
P
L
NQ
M
--
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
--
Y
PS
S
P
K
P
--
N
F
S
T
H
V
M
N
I
F
---
S
D
--
H
---
G
L
-
E
P
T
K
I
N
E
V
R
E
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
----
P
A
S
T
-------------------------------------------------------------------
30
HHSearch
65.39
18%
-39
- C2 -
-
3FZV
-
?
D:
[4-297]
-
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
---
A
E
A
S
R
K
L
Y
I
A
Q
P
S
I
S
T
A
V
--
L
E
E
S
F
-------------
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
---
L
R
M
A
H
E
F
E
Q
-----
N
D
V
I
A
G
----
Q
I
D
I
G
C
F
E
T
V
A
P
L
Y
L
P
G
L
I
A
G
-
F
R
Q
A
Y
P
G
V
E
I
R
I
R
D
G
E
Q
Q
E
L
V
Q
G
L
T
S
G
--------
R
F
D
--
L
A
F
L
Y
E
H
D--
L
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
P
H
A
L
L
P
E
G
H
R
F
--
A
--
G
--
Q
A
Q
V
S
L
R
D
L
C
L
E
P
M
I
L
--
L
--
D
V
Q
---
P
S
R
T
Y
F
V
S
L
F
---
E
E
--
L
---
G
L
-
T
P
N
I
A
F
S
S
P
S
I
E
M
V
R
G
M
V
G
Q
G
F
G
F
S
L
L
----
V
T
R
P
H
S
E
C
T
Y
D
G
-
K
K
V
V
M
V
----
D
L
A
-
E
--
P
V
S
T
S
G
L
A
A
A
W
-
L
---
K
R
A
Q
L
T
K
P
A
R
L
F
V
D
Y
C
R
E
Q
------
4
PsiBlast_PDB
63.62
24%
-28
- C2 -
-
3K1P
-
BENM_ACIAD
A:
[1-247]
-
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
Q
M
V
S
M
T
K
R
I
A
S
V
E
K
T
I
R
I
G
F
V
G
S
L
L
F
G
L
L
P
R
I
I
H
L
---------
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
-
E
A
L
K
E
G
-----
R
I
D
A
G
--
F
G
R
L
K
I
S
---
D
P
-
A
I
K
R
T
L
L
R
N
-
E
R
L
M
V
A
V
H
A
S
H
P
L
N
Q
M
--
K
--
D
K
G
V
H
L
N
D
L
I
D
E
K
I
L
L
--
Y
PS
S
P
K
P
--
N
F
S
T
H
V
M
N
I
F
---
S
D
--
H
---
G
L
-
E
P
T
K
I
N
E
V
R
K
V
Q
L
A
L
G
L
V
A
A
G
E
G
I
S
L
V
----
P
A
S
T
-------------------------------------------------------------------
33
HHSearch
60.53
15%
-47
- C2 -
-
3HHG
-
?
E:
[2-292]
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
---
L
Q
E
M
A
A
A
E
T
E
M
L
A
V
H
E
I
P
Q
G
----
V
L
S
V
D
S
A
M
P
M
V
L
H
L
L
A
P
L
A
A
K
-
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
S
---
E
G
Y
I
N
L
I
E
R
--------
K
V
D
--
I
A
L
R
A
G
E
L--
D
D
S
G
L
R
A
R
H
L
F
D
-
S
R
F
R
V
I
A
S
P
E
Y
L
A
--
K
--
H
--
G
T
P
Q
S
T
E
E
L
A
G
H
Q
C
L
G
--
F
--
T
E
P
G
--
S
L
N
T
W
--
A
V
L
---
D
A
QG
N
---
P
Y
-
K
I
S
P
H
F
T
A
S
S
G
E
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
----
S
D
F
L
V
D
N
D
I
-
A
E
-
G
K
L
I
P
L
----
L
A
E
-
Q
TS
D
KT-
H
P
F
N
A
V
Y
-
Y
---
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
------
13
PsiBlast_PDB
58.14
26%
-51
- C2 -
-
1IXC
-
?
A:
[24-220]
------------------------
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
-----
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
----
E
L
S
V
A
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
-
F
L
T
S
T
P
T
A
T
V
S
--------
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
T
I
H
V
G
F
S
R
F
F
P
R
---
H
P
-
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
--
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
--
F
P
R
G
G
R
P
--
S
F
A
D
E
V
I
G
L
F
---
K
H
--
A
---
G
I
-
E
P
R
I
A
-------------------------------------------------------------------------------------------------
41
HHSearch
56.53
20%
-32
* C2 *
-
1AL3
-
CYSB_KLEPN
A:
[88-294]
-----------------------------------------------------------------------------------------
T
W
P
D
K
G
----
S
L
Y
V
A
T
T
H
T
Q
A
R
Y
A
L
P
G
V
I
K
G
-
F
I
E
R
Y
P
R
V
S
L
H
M
H
Q
G
S
P
T
Q
I
A
E
A
V
S
K
G
--------
N
A
D
--
F
A
I
A
T
E
A
LH-
L
Y
D
D
L
V
M
L
P
C
Y
H
-
W
N
R
S
I
V
V
T
P
E
H
P
L
--
A
--
T
--
K
G
S
V
S
I
E
E
L
A
Q
Y
P
L
V
T
--
Y
--
T
F
G
F
--
T
G
R
S
E
L
D
T
A
F
---
N
R
--
A
---
G
L
-
T
P
R
I
V
F
T
A
T
D
A
D
V
I
K
T
Y
V
R
L
G
L
G
V
G
V
I
----
A
S
M
A
V
D
P
-
V
-
S
D
-
P
D
L
V
K
L
----
D
A
N
-
G
--
I
FS
H
S
T
T
K
I
G
F
-
R
---
R
S
T
F
L
R
S
Y
M
Y
D
F
I
Q
R
F
A
P
H
------
10
PsiBlast_PDB
55.88
24%
-72
- C2 -
-
2H98
-
CATM_ACIAD
A:
[89-256]
-----------------------------------------------------------------------------------------
S
Q
--------
T
L
R
I
G
Y
V
S
S
L
L
Y
G
L
L
P
E
I
I
Y
L
-
F
R
Q
Q
N
P
E
I
H
I
E
L
I
E
C
G
T
K
D
-
Q
I
N
A
L
K
Q
G
-----
K
I
D
L
G
--
F
G
R
L
K
I
T
---
D
P
-
A
I
R
R
I
M
L
H
K
-
E
Q
L
K
L
A
I
H
K
H
H
H
L
--
N
QF
A
--
A
T
G
V
H
L
S
Q
I
I
D
E
P
M
L
L
Y
P
V
--
S
Q
K
P
--
N
F
A
T
F
I
Q
S
L
F
---
T
E
--
L
---
G
L
-
V
P
S
K
L
T
E
I
R
E
I
Q
L
A
L
G
L
V
A
A
G
E
G
V
C
I
V
P
ASA
M
D
I
G
V
K
N
-
L
-
L
------------------------------------------------------------
31
HHSearch
55.58
22%
-9
- C2 -
-
1IXC
-
?
A:
[1-291]
-
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
-----
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
L
A
G
R
S
G
D
R
S
R
A
A
A
R
G
D
V
G
----
E
L
S
V
A
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
-
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
--------
T
I
H
--
V
G
F
S
R
F
F
P--
R
H
P
G
I
E
I
V
N
I
A
Q
-
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
--
F
--
G
K
T
C
K
L
A
D
L
R
A
V
E
L
T
L
--
F
--
P
R
G
G
RP
S
F
A
D
E
V
I
G
L
F
---
K
H
--
A
---
G
I
-
E
P
R
I
A
R
V
V
E
D
A
T
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
----
P
A
S
V
A
A
I
-
R
--
W
-
P
D
I
A
F
A
----
R
I
V
-
G
--
T
RVK
V
P
I
S
C
I
F
-
R
---
K
E
K
-
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
------
51
Fugue
55.10
17%
-94
- C2 -
-
1I6A
-
OXYR_ECOLI
A:
[87-298]
------------------------------------------------------------------------------------------
E
T
M
S
G
----
P
L
H
I
G
L
I
P
T
V
G
P
Y
L
L
P
H
I
I
P
M
-
L
H
Q
T
F
P
K
L
E
M
Y
L
H
E
A
Q
T
H
Q
L
L
A
Q
L
D
S
G
K
-----
L
D
A
V
I
--
L
A
L
V
K
E
S
---
E
A
--
F
I
E
V
P
L
F
D
-
E
P
M
L
L
A
I
Y
E
D
H
P
W
--
A
--
N
--
R
E
A
V
P
M
A
D
L
A
G
E
K
L
L
M
--
L
--
E
D
G
H
--
C
L
R
D
Q
A
M
G
F
C
---
F
E
--
A
---
G
A
-
D
E
D
T
H
F
R
A
T
S
L
E
T
L
R
N
M
V
A
A
G
S
G
I
T
L
L
----
P
A
L
A
V
P
P
-
E
-
R
K
-
R
D
G
V
V
Y
L
P
A
I
K
P
E
-
P
--
R
---
R
T
I
G
L
V
Y
R
P
GSP
L
R
S
R
Y
E
Q
L
A
E
A
I
R
A
R
M
D
G
H
F
D
----
54
Fugue
55.06
17%
-99
- C2 -
-
1I6A
-
OXYR_ECOLI
A:
[87-298]
-----------------------------------------------------------------------------------------
E
-
T
M
S
G
----
P
L
H
I
G
L
I
P
T
V
G
P
Y
L
L
P
H
I
I
P
M
-
L
H
Q
T
F
P
K
L
E
M
Y
L
H
E
A
Q
T
H
Q
L
L
A
Q
L
D
S
G
K
-----
L
D
-
A
V
--
I
L
A
L
V
-
K
---
E
S
E
A
F
I
E
V
P
L
F
D
-
E
P
M
L
L
A
I
Y
E
D
H
P
W
--
A
--
N
--
R
E
A
V
P
M
A
D
L
A
G
E
K
L
L
M
--
L
--
E
D
G
H
--
C
L
R
D
Q
A
M
G
F
C
---
F
E
--
A
---
G
A
-
D
E
D
T
H
F
R
A
T
S
L
E
T
L
R
N
M
V
A
A
G
S
G
I
T
L
L
----
P
A
L
A
V
P
P
-
E
-
R
K
-
R
D
G
V
V
Y
L
P
A
I
K
P
E
-
P
--
R
---
R
T
I
G
L
V
Y
R
P
---
G
S
-
P
L
R
S
R
Y
E
Q
L
A
E
A
I
R
A
R
M
D
GHFD
48
HHSearch
54.40
19%
-50
- C2 -
-
2HXR
-
CYNR_ECOLI
A:
[92-289]
---------------------------------------------------------------------------------------------------
S
L
R
I
A
V
T
P
T
F
T
S
Y
F
I
G
P
L
M
A
D
-
F
Y
A
R
Y
P
S
I
T
L
Q
L
Q
E
M
S
Q
E
K
I
E
D
M
L
C
R
D
--------
E
L
D
--
V
G
I
A
F
A
P
V--
H
S
P
E
L
E
A
I
P
L
L
T
-
E
S
L
A
L
V
V
A
Q
H
H
P
L
--
A
--
V
--
H
E
Q
V
A
L
S
R
L
H
D
E
K
L
V
L
--
L
--
S
A
E
F
--
A
T
R
E
Q
I
D
H
Y
C
---
E
K
--
A
---
G
L
-
H
P
Q
V
V
I
E
A
N
S
I
S
A
V
L
E
L
I
R
R
T
S
L
S
T
L
L
----
P
A
A
I
A
T
Q
-
H
----
D
G
L
K
A
I
----
S
L
A
-
P
--
P
L
L
E
R
T
A
V
L
L
R
-
R
---
K
N
S
W
Q
T
A
A
A
K
A
F
L
H
M
A
L
D
K
------
40
HHSearch
54.22
21%
-12
- C2 -
-
2H98
-
CATM_ACIAD
A:
[89-292]
---------------------------------------------------------------------------------------------
S
Q
----
T
L
R
I
G
Y
V
S
S
L
L
Y
G
L
L
P
E
I
I
Y
L
-
F
R
Q
Q
N
P
E
I
H
I
E
L
I
E
C
G
T
K
D
Q
I
N
A
L
K
Q
G
--------
K
I
D
--
L
G
F
G
R
L
K
I
--
T
D
P
A
I
R
R
I
M
L
H
K
-
E
Q
L
K
L
A
I
H
K
H
H
H
L
--
N
--
Q
FA
A
T
G
V
H
L
S
Q
I
I
D
E
P
M
L
L
--
Y
--
P
V
S
Q
KP
N
F
A
T
F
I
Q
S
L
F
---
T
E
--
L
---
G
L
-
V
P
S
K
L
T
E
I
R
E
I
Q
L
A
L
G
L
V
A
A
G
E
G
V
C
I
V
----
P
A
S
A
M
D
I
-
G
--
V
-
K
N
L
L
Y
I
----
P
I
L
-
D
--
D
DAY
S
P
I
S
L
A
V
-
R
---
N
M
D
-
H
S
N
Y
I
P
K
I
L
A
C
V
Q
E
V
------