@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZP5: (2017-12-16 )
MEPLIVIKGAKKIIRNKTILHLDRFTADAGDLVTVVGESGAGKSTLLNILGLNDQFSSGQFYLFDQETKQLTGREKRLIKRNTISFLFQDFGLIEYETIDFNLDIGLKFSNLNVSDKRTAKYEALKKVNINKKLSTPIYTLSGGEKQRIACARVLLKNSKIILADEPTGSLDKRNKDKVVEILSQQASQGTLVIVVTHDPYLTKIGNKKIML
Atome Classification :
(31 SA)
.........10....----....20........30........40........50........60........70........80.........90........100....-...---110..---.....120.......130.....-...140.......150.......160.......170.......180...-..-.-.-190.......-200..-.....210------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
P
L
I
V
IKG
A
K
K
I
IR----NK
T
I
L
H
L
DRFTADAG
D
L
V
T
V
VGESGA
G
K
S
T
L
L
N
I
LGLNDQFSSG
Q
F
Y
L
FDQ
E
T
K
Q
LT
G
R
E
K
R
L
I
K
-
R
N
T
I
S
F
L
F
Q
DFGL
I
E
Y
E
T
I
D
F
N
L
D
I
G
-
L
K
F
---SNLNV---SDK
R
T
A
K
Y
E
A
L
K
KVNI-NKKLST-
P
I
Y
T
LSGGE
K
Q
R
I
A
C
A
R
V
L
LKNS
K
I
I
L
ADEPTGSLDKR
N
K
D
K
V
V
E
I
L
S
Q
-QA-S-Q-G
T
L
V
I
V
V
THD-
P
Y
L
T
K-IGNKKIML------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
82.29
32%
-98
* C2 *
-
2PCL
5
LOLD_AQUAE
A:
[2-212]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
-
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
-
M
L
K
---
M
G
K
P
K
---
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
L
-
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
-
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
T
H
R
T
L
E
M
------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.30
36%
4
- C2 -
-
3TIF
4
Y796_METJA
A:
[31-218]
---------------------------------
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
KYR
G
A
M
S
G
---
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
-
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.58
37%
-1
- C2 -
-
1F3O
1
Y796_METJA
A:
[31-218]
---------------------------------
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
---
K
Y
R
G
A
MS
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
-
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.38
36%
8
- C2 -
-
1L2T
3
Y796_METJA
A:
[31-218]
---------------------------------
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
KYR
G
A
M
S
G
---
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
-
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.73
36%
8
- C2 -
-
3TIF
3
Y796_METJA
B:
[31-218]
---------------------------------
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
KYR
G
A
M
S
G
---
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
-
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
71.65
23%
-118
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[2-207]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
-----
P
A
--
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
---
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
-
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
-
L
H
-
K
R
L
-
G
R
T
M
I
Y
V
T
H
D
-
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
71.19
25%
-111
- C2 -
-
4TQU
-
?
T:
[1-208]
M
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
----
K
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
N
D
L
A
P
-----
K
--
D
R
D
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
-
L
R
L
---
K
R
T
K
K
---
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
-
Q
P
L
L
E
R
-
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
-
L
H
-
Q
R
L
-
G
T
T
V
I
Y
V
T
H
D
-
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
70.54
36%
9
- C2 -
-
1L2T
3
Y796_METJA
B:
[31-218]
---------------------------------
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
-
L
I
F
KYR
G
A
M
S
G
---
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
-
D
-
G
K
T
V
V
V
V
T
H
D
-
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
69.69
23%
-111
- C2 -
-
2AWN
1
MALK_ECOLI
B:
[2-207]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
P
-----
P
A
--
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
-
L
K
L
---
A
G
A
K
K
---
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
-
A
H
L
L
D
R
-
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
-
L
H
-
K
R
L
-
G
R
T
M
I
Y
V
T
H
D
-
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.23
35%
-32
- C2 -
-
2PCJ
-
LOLD_AQUAE
A:
[11-210]
----------
K
K
V
I
R
----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
-
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
M
L
K
M
---
G
K
P
K
K
---
E
A
K
E
R
G
E
Y
-
L
L
S
E
L
G
L
-
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
-
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
T
H
R
T
L
--------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
67.13
25%
-105
- C2 -
-
3FVQ
2
FBPC_NEIG1
B:
[2-212]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
N
T
N
-
L
-
P
V
R
-
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
---
G
K
G
R
T
---
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-
S
E
L
A
G
R
-
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
-
A
L
R
A
-
N
-
G
K
S
A
V
F
V
S
H
D
-
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.81
35%
-29
- C2 -
-
2PCL
5
LOLD_AQUAE
A:
[11-210]
----------
K
K
V
I
R
----
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
Y
T
N
E
K
E
L
S
L
L
R
-
N
R
K
L
G
F
V
F
Q
F
H
Y
L
I
P
E
L
T
A
L
E
N
V
I
V
P
M
L
K
M
---
G
K
P
K
K
---
E
A
K
E
R
G
E
Y
-
L
L
S
E
L
G
L
-
G
D
K
L
S
R
-
K
P
Y
E
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
-
I
N
-
E
-
G
-
G
T
S
I
V
M
V
T
H
E
-
R
E
L
A
E
-
L
T
H
R
T
L
--------------------------------------------------------------------------------------------------------------------------------
101
Fugue
66.37
28%
19
- C2 -
-
3TUZ
1
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
-
L
E
L
---
D
N
T
P
K
---
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
H
D
S
-
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
-
I
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
-
M
D
V
V
K
-
R
I
C
D
C
V
A
V
ISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
90
HHSearch
66.28
25%
-100
- C2 -
-
2YYZ
1
?
A:
[2-207]
--
P
S
I
R
V
V
N
L
K
K
Y
F
G
----
K
V
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
I
Y
F
D
D
V
L
V
N
D
I
P
P
-----
K
--
Y
R
E
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
-
L
R
A
---
R
R
I
S
K
---
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
-
D
N
L
L
D
R
-
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
-
L
Q
-
Q
E
L
-
G
I
T
S
V
Y
V
T
H
D
-
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
66.00
31%
-7
- C2 -
-
3C4J
2
?
B:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
65.64
31%
-4
- C2 -
-
2OLK
1
?
D:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.34
31%
-14
- C2 -
-
3C41
2
?
K:
[29-211]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
65.27
31%
-10
- C2 -
-
2OLK
1
?
C:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.45
31%
-13
- C2 -
-
4YMT
-
?
J:
[24-209]
------------------------------
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
---
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.13
31%
1
- C2 -
-
2OLJ
3
?
A:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.76
31%
-8
- C2 -
-
4YMU
1
?
J:
[24-209]
------------------------------
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
---
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
63.58
31%
-9
- C2 -
-
4YMU
1
?
A:
[24-209]
------------------------------
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
---
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.33
31%
-11
- C2 -
-
4YMV
1
?
J:
[24-209]
------------------------------
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
---
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
63.28
31%
-15
- C2 -
-
4YMV
1
?
A:
[24-209]
------------------------------
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
--
D
G
V
K
I
N
N
G
K
V
N
I
N
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
---
K
K
M
N
K
---
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
Y
-
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
I
F
M
------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.89
31%
-7
- C2 -
-
3C4J
2
?
A:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.61
31%
-2
- C2 -
-
2OLK
2
?
B:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.03
31%
-7
- C2 -
-
3C41
2
?
J:
[29-211]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
61.93
31%
-13
- C2 -
-
2OLK
1
?
A:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.96
31%
-13
- C2 -
-
2Q0H
3
?
B:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.76
31%
-1
- C2 -
-
2Q0H
3
?
A:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
56.40
31%
-3
- C2 -
-
2OLJ
2
?
B:
[50-232]
---------------------------------
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
---
D
G
I
N
L
K
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
---
R
K
W
P
R
---
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
A
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
-
L
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
-
V
G
D
R
V
L
F
M
------------------------------------------------------------------------------------------------------------------------------