@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U105: (2017-12-18 )
MENKEQAQQAVYKETIDSLMQQTQSSTDGLSTTQAKEKLERDGLNQLKEKPKKPTWKLFLETFKDAMVIVLLIVALIQMVMGDYIEFLVIFAVLMLNSIISVVQTKKAEGSLEALKNLSAPDARVIRDGKEKTIPANELVVGDIVLLDAGDYVPADGRLLDAGSLKVDEGMLTGESTSAEKEVTDITSTVPIGDRTNMVFSGTIVTYGRGKFLVTSTGNNTEIGQVAGLLESTTEQVTPLQRGLDKFSKKLSLAILALSLLILGIQLFRIYLGEGTGDMTADIVSAVMFAVAVAVAAIPEALQSIVTIVLSLGTNKMAKRHAIIRKLPAVETLGSTSIICTDKTGTLTQNKMTVVDYFLGNGDTGDFTNDPSKWTADERRLIEISVLANDASISEDGTKLGDPTEVAFIDFSEKLNQPYQEIRNNYPRQAELPFDSDRKLMSTGHTIDNKNYLFVKGGPDIVFQRSKKVLLNGEVVPMTDELMKKFQEQNEAFSTRALRVLAFAYRPLDNFDLSFEDEDDLILVGLLAMIDPPRAEVTQAVTEARSAGIKTIMITGDHKTTAVAIAKQIGIFEEGNLALTGTELDELTEDQLNEVLEKVTVYARVSPENKIRIVRAWQNKGHISAMTGDGVNDAPALKQADIGIAMGTGTDVAKDAAAMVLTDDNFASIVSAVEVGRNVFDNIKKAISYLFAGNLGAIIAIIFALVADWSNPFTALQLLFINLVNDSLPAIALGTEKAEPATMNRPPRDPNSGIFTDKTLISVTYRGVLIGIAVIFAQWLGMQHSPEFGVAMSFSTLIWCRTLQTFPARSNTQTAIQAGFFSNRSVLLAVVVCSALYCLTMIPGLKEVFSIPSAFGLTEVFTCMGIALVTIVLMEITKLIIVRVQGNK
Atome Classification :
(20 SA)
.........10........20....-.-..-.30........40........50........60........70.....-------...80-----------..-------------.----------....-..90........100.......110.......120.......130.--........140.......150.......160-.--..--.....170.......180.....-..190.-......200.......210.......220.......230.......240.......250--.......260.......270.......280.......---290.......300.......310.......320.......330.......340.......350.......360---...-------------------..------..--------------------.370------.------------......----.380.---......390-...--------...-----..-----400------.........410....----------------...420---------------....----------------....430.......440...----...------.------450----.........460.......470.......480.......490..--.--....500...--.--.---------.---------.510----------....-...-------520-----.........530.......540.......550.......560.......570..----.----.------------------------...580.......590.....--..600.........610.......620.......630.......640.....-..650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750........760....-...770.......-780---------------------------------.--------------------------------------......790.......800.......810.......820.......830......-.840........850-.......860.......870.......880......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
N
K
E
Q
A
Q
Q
A
V
Y
K
E
T
I
D
S
L
M
Q
Q
TQS-S-TD-GL
S
T
T
Q
A
K
E
K
L
E
R
D
G
L
N
Q
L
K
EKPKK
P
T
W
K
L
F
L
E
T
F
K
D
A
M
V
I
V
L
L
I
V
A
L
-------
I
Q
M
V
------------
M
G
-------------
D
----------
Y
I
E
F
-
L
V
I
F
A
V
L
M
L
N
S
I
I
S
V
V
Q
TKKAEG
S
L
E
A
L
K
NLSAP
D
A
R
V
IRDGK--E--KTIPAN
E
L
V
V
G
D
I
V
L
L
DAGDYVPAD
G
R
L
LD--A--GS--
L
K
VDEGMLTGESTSAEKEVTDIT-STVPIG-DRT
N
M
V
F
S
G
T
I
V
T
YGR
G
K
F
L
V
T
STGNNT
E
I
G
Q
V
A
G
L
L
E
S
T
T
E
Q
V
T
P
L
Q
R
G
L
D
K
F
S
K
K
L
S
--
L
A
I
L
A
L
S
L
L
I
L
G
I
Q
L
F
R
I
YLGEGTG
D
M
T
A
D
I
V
S
A
V
M
F
---
A
V
A
V
A
V
A
A
I
P
E
A
L
Q
S
I
V
T
I
V
L
SLG
T
N
K
M
A
K
R
H
A
I
I
R
KLPAVETLGS
T
S
I
I
C
TDKTGTLTQN
K
M
T
V
V
D
Y
F
LGN----GDT-------------------GD------FT--------------------NDP-------S------------KWTADE----
R
R
L
I
E
---
I
S
V
L
ANDA--SIS--------EDG-----TK-----L--------GDPT
E
V
A
F
I
D
F
S
E
K
LN----------------
Q
P
Y
Q
E
----------------
I
R
NN----------------YPRQAELPFDSDRK
L
M
STGH----TID------N------K------
N
Y
L
F
V
KGGP
D
I
V
F
QRS
K
K
V
L
LNGEVVP
M
T
D
E
L
M
K
K
F
Q
E
Q
N
E
A
F
S
--
T
--
R
A
L
R
V
L
A
F
A
Y--R--P---------L---------DNFD----------LSFE-DED-------
D
-------
L
I
L
V
G
L
L
A
MIDP
P
R
A
E
V
T
Q
A
V
T
E
A
R
SAG
I
K
T
I
M
I
TGDH
K
T
T
A
V
A
I
A
K
QIGIFEE----G----
N
------------------------
L
A
L
TG
T
E
L
D
E
L
T
E
D
Q
L
N
E
V
L
E
--
K
V
T
--
V
Y
A
R
VSPE
N
K
I
R
I
V
R
A
WQNKG
H
I
S
A
MTGDGVNDAPALKQAD
I
G
I
A
MG-TGTDVAKD
A
A
A
M
V
L
TDD
N
F
A
S
I
V
S
A
V
E
V
G
R
N
V
F
D
N
I
K
K
A
I
S
Y
L
FAG
N
L
G
A
I
I
A
I
I
F
A
L
V
ADWS
N
P
F
T
A
L
Q
L
L
F
I
N
L
VNDSL
P
A
I
ALGTEKAEPATMNRPPRDPN-SGIFTD
K
T
L
I
S
V
T
Y
R
-
G
V
L
I
G
I
A
V
I
F
A
Q
W
-LGM---------------------------------Q--------------------------------------HSPEFGV
A
M
S
F
S
T
L
I
W
C
R
T
L
Q
TFPARSNT
Q
T
A
I
QAGFFSN
R
S
V
L
L
A
V
V
V
C
S
A
L
Y
C
-
L
T
M-IP
G
L
K
E
V
FSIP-
S
A
F
G
L
T
E
V
F
T
C
M
G
I
A
L
V
T
I
V
L
M
E
I
T
K
L
I
I
V
R
VQGNK
71
PsiBlast_CBE
93.68
37%
0
- C- -
-
1WPG
3
AT2A1_RABIT
B:
[2-830]
-------
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
-
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
WFEEGEETIT---
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
--
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
-
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
-----
I
R
G
A
I
Y
Y
FKI
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
D
-------------------
G
D
------
F
C
SLNEFSITGSTYAPEGEVLK
N
D
K
-------
P
------------
I
R
S
G
Q
F
----
D
G
L
V
E
LAT
I
C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
-----
T
K
GVYEK
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
----------------
V
R
N
L
SKVERANACNSVIRQL
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
------
K
------
S
SRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
--
T
GR
D
T
L
R
C
L
A
L
A
T
--
R
--
D
TPPKREEMV
L
---------
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
93.68
37%
0
- C- -
-
1WPG
3
AT2A1_RABIT
C:
[2-830]
-------
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
-
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
WFEEGEETIT---
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
--
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
-
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
-----
I
R
G
A
I
Y
Y
FKI
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
D
-------------------
G
D
------
F
C
SLNEFSITGSTYAPEGEVLK
N
D
K
-------
P
------------
I
R
S
G
Q
F
----
D
G
L
V
E
LAT
I
C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
-----
T
K
GVYEK
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
----------------
V
R
N
L
SKVERANACNSVIRQL
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
------
K
------
S
SRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
--
T
GR
D
T
L
R
C
L
A
L
A
T
--
R
--
D
TPPKREEMV
L
---------
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
93.68
37%
0
- C- -
-
1WPG
3
AT2A1_RABIT
D:
[2-830]
-------
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
-
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
WFEEGEETIT---
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
SV
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
--
K
S
TT
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
-
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
KV
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
-----
I
R
G
A
I
Y
Y
FKI
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
D
-------------------
G
D
------
F
C
SLNEFSITGSTYAPEGEVLK
N
D
K
-------
P
------------
I
R
S
G
Q
F
----
D
G
L
V
E
LAT
I
C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
-----
T
K
GVYEK
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
----------------
V
R
N
L
SKVERANACNSVIRQL
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
------
K
------
S
SRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
--
T
GR
D
T
L
R
C
L
A
L
A
T
--
R
--
D
TPPKREEMV
L
---------
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.68
37%
0
- C- -
-
1WPG
3
AT2A1_RABIT
A:
[2-830]
-------
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
-
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
W
F
EEGEETIT---
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
--
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
-
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
-----
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
D
-------------------
G
D
------
F
C
S
L
N
E
F
S
I
T
G
STYAP
E
G
E
V
L
K
N
D
K
-------
P
------------
I
R
S
G
Q
F
----
D
G
L
V
E
L
A
T
I
C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
-----
T
K
G
V
Y
E
K
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
----------------
V
R
N
L
SKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
------
K
------
S
SRAAV
G
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
--
T
GR
D
T
L
R
C
L
A
L
A
T
--
R
--
D
TPPKREEMV
L
---------
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
79.42
37%
-4
- C2 -
-
3AR4
5
AT2A1_RABIT
A:
[2-992]
-------
M
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
W
F
EEGEETIT---
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
K
S
V
--
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
KS
T
T
--
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
-
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
--
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
I
R
G
A
I
Y
Y
F
K
I
---
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
--------------------
D
G
------
D
F
C
S
L
N
E
F
S
I
T
G
ST--------
Y
A
P
-------
E
G
E
V
L
K
ND
K
P
I
R
S
G
Q
F
D
G
L
----
V
E
L
A
T
---
I
C
A
L
C
N
D
S
--
S
L
D
F
NETK---
G
V
Y
-----
E
K
-----
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
VRNLS
K
V
E
R
A
N
A
C
N
S
V
I
R
Q
L
----------------
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
KSSRAA
V
------
G
------
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
TG
R
--
D
T
L
R
C
L
A
L
A
T
--
R
--
D
---------
T
---------
P
P
K
R
EEMVLDDSS-
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
----
N
EEVA
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
-
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
M
---------------------------------
Y
AEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEI------
F
E
A
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
Y
-
V
D
P
L
P
M
I
F
K
L
K
A
L
--
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
----
106
HHSearch
77.78
34%
-9
- C2 -
-
2ZXE
2
?
A:
[44-1020]
------
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
D
L
-
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
-------
L
C
F
L
------------
A
Y
G
I
Q
A
A
TEDEPAN
D
N
----------
L
Y
L
G
-
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
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A
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I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
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P
Q
T
R
S
P
E
F
S
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---
E
N
P
L
-
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F
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C
V
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G
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A
R
G
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V
V
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T
G
D
R
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M
G
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L
A
S
G
L
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V
G
R
T
P
I
A
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I
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H
F
I
H
I
I
T
--
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
----------
S
W
L
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
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A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
----
Q
I
--------------------
H
E
------
A
D
--------------------
T
T
E
NQSGAAF
D
------------
K
T
S
A
T
W
----
S
A
L
S
R
---
I
A
A
L
C
N
R
A
--
V
F
Q
A
GQDNVPI
L
K
R
-----
S
V
-----
A
--------
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
----
E
N
E
KSSE--
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
--
F
--
A
---------
L
---------
P
E
D
K
YNEG
Y
P
F
D
AD
E
P
N
F
-
P
T
T
-------
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
--
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
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G
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A
M
G
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G
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K
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A
A
D
M
I
L
L
D
D
N
F
A
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V
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E
G
R
L
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N
L
K
K
S
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A
Y
T
L
T
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N
I
P
E
I
T
P
F
L
V
F
I
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G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
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S
L
A
Y
E
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A
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S
D
I
M
K
R
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P
R
N
P
K
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
G
Q
I
G
M
I
Q
A
L
G
G
F
F
S
Y
F
-
V
I
L
---------------------------------
A
E
N
GFLPMDLIGK
R
V
R
W
D
DRWIS
D
V
E
D
SFG
Q
Q
W
T
Y
E
Q
R
K
I
V
E
F
T
C
H
T
S
F
F
I
S
I
V
V
V
Q
W
A
D
L
I
I
C
K
T
R
R
N
S
I
F
Q
Q
G
-
M
K
N
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
-
C
P
G
T
D
V
A
L
R
M
Y
P
L
--
K
P
S
W
W
F
C
A
F
P
Y
S
L
I
I
F
L
Y
D
E
M
R
R
F
I
I
R
R
S
P
G
G
-
130
Fugue
76.44
36%
-8
- C2 -
-
1SU4
-
AT2A1_RABIT
A:
[1-994]
M
E
A
-------
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
-
S
-
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
-------------
W
F
EEGEETITA
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
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R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
S
V
Q
R
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K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
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R
I
L
S
IK
S
--
T
T
--
L
R
V
D
Q
S
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L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
D
P
R
A
V
N
Q
-
D
K
K
N
M
L
F
S
G
T
N
I
A
A
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A
L
G
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V
A
T
T
G
V
S
T
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I
G
K
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D
Q
M
A
A
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K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
--
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
I
R
G
A
I
Y
Y
F
K
I
---
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
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V
R
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L
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S
V
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L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
D
----
K
V
D
GD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
------
V
L
--------------------
K
N
D
-------
K
------------
P
I
R
S
G
Q
F
D
G
L
V
E
L
A
T
---
I
C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
TKG
V
Y
E
K
-----
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
VFNTEVRNLSKVERAN
A
C
N
S
V
----------------
I
R
Q
L
----------------
M
K
K
E
F
T
L
E
F
S
R
D
R
K
S
M
S
V
Y
C
----
S
P
A
------
K
SSRAAV
G
------
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
R
V
P
M
T
G
P
V
K
E
K
I
L
S
V
I
K
E
W
G
T
G
R
--
D
T
L
R
C
L
A
L
A
T
--
R
--
D
---------
T
PPKREEMVL
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
----
N
EEVA
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
-
G
G
Y
V
G
A
A
T
V
G
A
A
A
-
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCE
I
--------------------------------------
F
E
A
P
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
L
S
E
N
Q
S
L
M
R
M
P
P
W
V
N
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
-
L
I
L
Y
V
D
P
L
P
M
I
F
K
L
K
-
A
-
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
Y
L
E
G
-
34
PsiBlast_CBE
74.69
37%
11
- C2 -
-
4H1W
1
AT2A1_RABIT
A:
[2-833]
-------
E
A
A
H
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
-
E
-
T
T
-
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
-------
I
S
F
V
------------
L
A
WFET---------
A
----------
F
V
E
P
-
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
A
D
R
--
K
S
V
Q
R
I
K
A
R
D
I
V
P
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
--
I
--
K
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
T
E
P
V
P
-
D
P
R
A
V
N
Q
D
K
K
N
M
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
W
-----
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
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L
P
A
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I
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T
C
L
A
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R
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K
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A
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L
P
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D
K
T
G
T
L
T
T
N
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M
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V
C
K
M
F
I
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D
----
K
V
D
-------------------
G
D
------
F
C
S
L
N
E
F
S
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G
STYAP
E
G
E
V
L
K
N
D
K
-------
P
------------
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R
S
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Q
F
----
D
G
L
V
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L
A
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C
A
L
C
N
D
S
--
S
L
D
--------
F
N
E
-----
T
K
G
V
Y
E
K
V
--------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
N
----------------
V
F
N
T
E
----------------
V
R
N
L
SKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
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R
D
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C
----
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P
A
------
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------
S
SRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
I
D
R
C
N
Y
V
R
V
G
T
T
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P
M
T
G
P
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K
E
K
I
L
S
V
I
K
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--
T
GR
D
T
L
R
C
L
A
L
A
T
--
R
--
D
TPPKREEMV
L
---------
D
D
S
S
----------
R
F
M
E
-
Y
E
T
-------
D
-------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
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A
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I
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V
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M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
F
G
E
NEEV
A
----
D
------------------------
R
A
Y
T
G
R
E
F
D
D
L
P
L
A
E
Q
R
E
A
C
R
--
R
A
C
--
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
G
L
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
N
P
P
D
L
D
I
M
D
R
P
P
R
S
P
K
-
E
P
L
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
74.03
35%
8
- C2 -
-
4XE5
1
AT1A1_BOVIN
A:
[32-852]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
-
D
L
S
R
-
G
L
T
T
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
V
-------
L
C
F
L
A
Y
G
I
Q
AATEEEP
Q
N
-------------
D
----------
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
N
G
E
--
K
--
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
N
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
D
F
T
-
N
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
E
Y
T
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
-
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQS
G
V
S
F
D
--------------------
K
T
S
-------
A
------------
T
W
L
A
L
S
----
R
-------
I
A
G
L
C
N
R
A
--
V
F
Q
--------
A
N
Q
-----
D
N
-----
L
PILKRAVA
G
D
A
S
E
S
A
L
L
K
C
I
E
V
C
C
----------------
G
S
V
K
E
----------------
M
R
E
R
----------------
Y
T
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
----
K
N
A
------
N
AGEP--
R
------
H
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
S
I
L
I
H
G
K
E
Q
P
L
D
E
E
L
K
D
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
--
L
L
L
P
---------
D
---------
E
Q
F
P
----------
E
G
F
Q
F
D
T
D
-------
D
VNFPVDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
V
E
D
I
A
A
R
L
NIPVSQVNPRDAR
A
C
V
V
H
G
S
D
L
K
D
M
T
P
E
Q
L
D
D
I
L
K
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
I
F
I
I
A
N
I
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
Q
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
73.64
35%
16
- C2 -
-
5AW4
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.62
35%
16
- C2 -
-
5AW8
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
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P
Q
Q
K
L
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G
C
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R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
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I
G
V
A
M
G
I
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G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
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T
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N
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L
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F
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G
N
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P
L
P
L
G
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V
T
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L
C
I
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L
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T
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A
I
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L
A
Y
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Q
A
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D
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M
K
R
Q
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R
N
P
K
-
T
D
K
L
V
N
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L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
73.61
35%
16
- C2 -
-
5AVX
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
73.61
35%
16
- C2 -
-
5AW6
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
73.56
35%
16
- C2 -
-
5AW2
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
73.54
35%
16
- C2 -
-
5AVZ
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
73.54
35%
16
- C2 -
-
5AW5
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
73.48
35%
16
- C2 -
-
5AW3
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
73.47
35%
16
- C2 -
-
5AW7
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
73.45
35%
16
- C2 -
-
5AW1
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
G
A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
S
T
E
V
L
D
D
I
L
H
--
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
73.44
35%
16
- C2 -
-
5AVY
2
?
A:
[39-859]
-
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
N
K
Y
G
T
-
D
L
T
R
-
G
L
T
N
A
R
A
K
E
I
L
A
R
D
G
P
N
S
L
T
P
P
P
T
T
P
E
W
I
K
F
C
R
Q
L
F
G
G
F
S
I
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
Q
A
A
------------
T
E
-------------
D
EPAN
D
N
L
---
Y
L
G
--
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
D
G
E
--
K
--
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
--
A
--
H
G
--
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
-
P
E
F
S
-
S
E
N
P
L
E
-
T
R
-
N
I
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
Y
S
W
L
------------
E
A
V
I
F
---
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
D
T
-------------------
T
E
NQSGAA
F
D
--------------------
K
T
S
-------
A
------------
T
W
S
A
L
S
----
R
-------
I
A
A
L
C
N
R
A
V
F
Q
A
G
--------
Q
D
N
-----
V
P
-----
I
LKRSVA--
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
C
----------------
G
S
V
Q
G
----------------
M
R
D
R
----------------
N
P
K
I
V
E
I
P
F
N
S
T
N
K
Y
Q
L
S
I
H
ENEK
S
S
E
------
S
------
R
------
Y
L
L
V
M
K
G
A
P
E
R
I
L
D
R
C
S
T
I
L
L
N
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A
E
E
P
L
K
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
--
G
--
L
G
E
R
V
L
G
F
C
H
F
A
L
--
P
---------
E
---------
D
K
Y
N
----------
E
G
Y
P
F
D
A
D
EPNFPTT
D
-------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
S
E
----
G
----
N
ET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
L
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T
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V
L
D
D
I
L
H
--
Y
H
T
E
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V
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A
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L
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N
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L
A
Y
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A
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S
D
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M
K
R
Q
P
R
N
P
K
-
T
D
K
L
V
N
E
R
L
I
S
M
A
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------