@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U238: (2017-12-22 )
MVDMLDKETKQNLEQYLALIESPIVFSVSLDNSENSQKLAEFTKEIAEMSPKISWEKRDSMRTPSFSINPVGKESGIVFAGIPLGHEFSSFLLAMLQISGRAPKISESLSLKIKKITQTLHFDSYVSLTCHNCPDVVQALNILAVLNPNITHTMIEGGMFQKEIDDKKIMAVPTVFLNGEEFSSGRMTIEQIVEKITGPLIEEELFEKEPYDVLVIGGGPAASSAAIYAARKGIRTGLVADSFGGQVVETLGIENMIGTSYTEGPKLMQQVESHVRSYPIDIMMNQQAVSLNKEQHFINIGLANGISLKAKTAIIATGAHWRSINVPGEKEFKNKGIAYCPHCDGPLFKGKEIAVIGGGNSGVEAAIDLAGLAKHVYVLEFLPELKADQILQDKLVSLANVTVIKHAATKEISGTNQVESLSYIDRRTMEMHTLAVSGVFILVGLLPNTDWLDGTIEMNPRNEIVTEKNGATNIPGVFAAGDCTDSPYKQIIVSMGSGATAALGAFDYLMRT
Atome Classification :
(20 SA)
.........10........20........30........40........50.....--...60--........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190....-.---..--200.......210.......220.......230.......240.......250.......260.......270.......280.......290--...---...---..300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410...-.-.-..420.......430.......440.......450...-....460.......470.......480....--...490.......500.......510---
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVDM
L
D
K
E
T
K
Q
N
L
E
Q
Y
L
A
L
IES
P
I
V
F
S
V
SLDNSE
N
S
Q
K
L
A
E
F
T
K
E
I
A
E
MSPK
I
S
WE--KRDSM--RTPS
F
S
INPVGKES
G
I
V
F
AGIPLG
H
E
F
S
S
F
L
L
A
M
L
Q
ISGRAPKI
S
E
S
L
S
L
K
I
K
K
I
T
Q
T
LHFD
S
Y
V
S
L
TCHN
C
P
D
V
V
Q
A
L
N
I
L
A
VLNPNI
T
H
T
M
IEGGMFQKEIDDK
K
I
M
A
V
P
T
V
F
LNGEEFSSG
R
M
T
I
E
Q
I
V
E
K
I-T---G
P
--
L
I
E
E
E
L
FEKEPY
D
V
L
V
IGGGPAAS
S
A
A
I
Y
A
A
R
K
GIRTGLVADSFG
G
Q
V
V
E
T
LGIENMIGTSYTE
G
P
K
L
M
Q
Q
V
E
S
H
V
R
SYP
I
D
I
M
M
NQQAVSL---NKE---
Q
H
F
---
I
N
I
GLAN
G
I
S
L
K
A
K
T
A
I
I
A
TGA
H
W
R
SINVPG
E
K
E
FKNKG
I
A
YCPHCDGPLFKG
K
E
I
A
V
I
GGGNS
G
V
E
A
A
I
D
L
A
G
L
A
K
H
V
Y
V
L
E
F
L
P
ELK
A
D
Q
I
L
Q
D
K
L
V
S
L
A
N
V
T
V
I
K
HAATKEISGT-N-Q-
V
E
S
L
S
Y
I
D
R
R
T
M
E
M
H
T
L
AVS
G
V
F
I
L
V
GLLPNTDWLD
G
T
-
I
E
MNPRN
E
I
VTEKNGATNIP
G
V
F
AAGDCTDS--
P
Y
K
Q
I
I
VSMGSG
A
T
A
A
L
G
A
F
D
Y
L
MRT---
1
PsiBlast_PDB
81.13
51%
-7
- C2 -
-
4O5Q
16
AHPF_ECOLI
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
S
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
---
G
A
EK
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
6
PsiBlast_PDB
80.83
51%
-7
- C2 -
-
4YKG
10
AHPF_ECOLI
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
S
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
---
G
A
EK
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
-
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
2
PsiBlast_PDB
80.71
51%
-5
- C2 -
-
4O5U
1
AHPF_ECOLI
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
S
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
---
G
A
EK
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
4
PsiBlast_PDB
80.24
51%
-6
- C2 -
-
4XVG
1
AHPF_ECOLI
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
S
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
---
G
A
E
K
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
3
PsiBlast_PDB
79.74
51%
-3
- C2 -
-
4YKF
8
AHPF_ECOLI
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
S
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
---
G
A
EK
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
5
PsiBlast_PDB
79.71
51%
2
- C3 -
-
1HYU
1
AHPF_SALTY
A:
[1-518]
---
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
--
E
D
N
T
L
PV
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
---
G
A
EK
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
98
Fugue
79.28
51%
2
* C3 *
-
1HYU
1
AHPF_SALTY
A:
[1-521]
---
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
T
L
P
V
--
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
-
D
TGA
E
K
--
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
---
V
P
A
---
A
T
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
-
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
KIA
110
HHSearch
61.63
55%
-42
* C2 *
-
1FL2
1
AHPF_ECOLI
A:
[1-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
---
I
P
A
AVE
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
-
G
S
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
----
7
PsiBlast_PDB
60.89
55%
-40
- C2 -
-
1FL2
1
AHPF_ECOLI
A:
[2-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
---
G
G
L
---
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
-
K
-
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
--
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
---
13
PsiBlast_PDB
59.94
32%
-96
- C2 -
-
3F8D
1
?
A:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
-----
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
23
PsiBlast_CBE
59.67
33%
-96
- C2 -
-
3F8R
3
?
B:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
----
D
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
24
PsiBlast_CBE
59.58
33%
-95
- C2 -
-
3F8P
1
?
D:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
G
---
D
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
12
PsiBlast_PDB
59.53
33%
-95
- C2 -
-
3F8R
3
?
A:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
-----
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
29
PsiBlast_CBE
59.27
32%
-96
- C2 -
-
3F8D
3
?
B:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
----
D
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
11
PsiBlast_PDB
59.14
33%
-98
- C2 -
-
3F8P
1
?
A:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
------
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
21
PsiBlast_CBE
59.02
33%
-92
- C2 -
-
3F8R
3
?
D:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
G
---
D
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
26
PsiBlast_CBE
58.89
33%
-98
- C2 -
-
3F8P
2
?
B:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
----------
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
27
PsiBlast_CBE
58.82
32%
-95
- C2 -
-
3F8D
2
?
D:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
R
G
---
D
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
25
PsiBlast_CBE
58.62
33%
-94
- C2 -
-
3F8P
1
?
C:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
------
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------
22
PsiBlast_CBE
58.53
33%
-97
- C2 -
-
3F8R
3
?
C:
[14-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
L
D
I
V
E
K
I
E
---
N
------
E
F
---
V
V
K
T
K
R
K
G
-
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
-
V
-
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
WL
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
------