@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2G1: (2017-12-22 )
MKLVLLRHGESEANFENYWTGWLDVALTEKGKEQAAVAGQKMLEAGLQFDAVYTSVLKRAILTGQVALEEMGQLWLPIIKTWRLNERHYGDLVGKNKDKMKEIYGKDQVKTWRRGYTEVPPLTAENRFDRRYDHLDPHLIPYGESLEMTVNRIIPLWQDHLAPKLKDRQDLLVVGHGNSIRALTKYLEDVPEDQMDTIDIPNAQPIQYTLADDLTILDKKIL
Atome Classification :
(48 SA)
.........10........20........30........40........50........60........70........80........90........100.......110....-------...120----..-----....-------.----.------130----...--...---.-.----------.-------140.......150.......160.......170.......180.......190.......200.......210.......220
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
L
V
L
L
RHGESEA
N
F
E
N
Y
W
T
G
W
L
D
V
A
LTEKG
K
E
Q
A
A
V
A
G
Q
K
M
L
E
AGLQ
F
D
A
V
Y
T
S
V
L
K
R
A
I
LT
G
Q
V
A
L
E
E
M
G
Q
L
W
L
P
I
I
K
TWRLNERH
Y
G
D
LVGK
N
K
D
K
M
K
E
I
YG
K
D
Q
V
K
T
W
R
RGY-------TEVPP-----LT-----AEN
R
-------
F
----
D
------
R
------RYD--HLD---P-H----------L-------IPYG
E
S
L
E
M
T
V
N
R
I
I
P
L
W
Q
D
HLAPKLKDRQ
D
L
L
V
V
GHG
N
S
I
R
A
L
T
K
Y
L
E
DVPEDQMDTIDIPNAQ
P
I
Q
Y
TLAD
D
L
T
I
LDKKIL
110
HHSearch
90.48
45%
0
- C- -
-
3GP3
-
GPMA_BURP1
C:
[10--7]
Y
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
-----
A
L
EPGD-
E
R
A
P
Y------
A
----
D
------
P
------
R
Y
A
--
K
V
P
---
R
-
E
----------
Q
-------
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
P
I
R
----
105
HHSearch
87.97
43%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
D:
[4-228]
Y
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
-------
D
V
P
P
P
-----
P
M
-----
E
P
D
H
P------
F
----
Y
SNISKD
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
K
P
I
K
----
13
PsiBlast_PDB
87.23
45%
0
- C- -
-
3GP3
-
GPMA_BURP1
A:
[11--9]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------
57
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
B:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
56
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
C:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
55
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
D:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
54
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
E:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
53
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
F:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
52
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
G:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
51
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
H:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
47
PsiBlast_CBE
87.10
41%
0
- C- -
-
1YJX
4
PGAM1_HUMAN
L:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
19
PsiBlast_PDB
87.10
41%
0
- C- -
-
1YJX
1
PGAM1_HUMAN
A:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
22
PsiBlast_CBE
82.35
47%
9
- C1 -
-
5UM0
1
GPMA_NEIG2
C:
[9-232]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
L----
L
D
-----
K
D
D
A
-------
F
SAHK
D
------
R
------
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
---
101
HHSearch
82.24
47%
6
- C1 -
-
5UM0
1
GPMA_NEIG2
C:
[9-234]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
-----
L
L
-----
D
K
D
D
A------
F
----
S
------
A
HKDR--
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
F
Y
-
23
PsiBlast_CBE
81.65
47%
9
- C1 -
-
5UM0
1
GPMA_NEIG2
B:
[9-232]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
L----
L
D
-----
K
D
D
A
-------
F
SAHK
D
------
R
------
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
---
1
PsiBlast_PDB
81.57
47%
8
- C1 -
-
5UM0
1
GPMA_NEIG2
A:
[9-232]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
L----
L
D
-----
K
D
D
A
-------
F
SAHK
D
------
R
------
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
---
115
HHSearch
80.85
46%
-30
- C- -
-
3D8H
-
?
B:
[21-244]
Y
K
L
T
L
I
R
H
G
E
S
E
W
N
K
E
N
R
F
T
G
W
T
D
V
S
L
S
E
Q
G
V
S
E
A
I
E
A
G
R
M
L
L
E
K
G
F
K
F
D
V
V
Y
T
S
V
L
K
R
A
I
M
T
T
W
T
V
L
K
E
L
G
N
I
N
C
P
I
I
N
H
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
S
E
T
A
S
K
F
G
E
D
Q
V
K
I
W
R
R
S
F
-------
D
V
P
P
P
-----
V
-----------------
L
----
E
------
K
------
S
D
P
--
R
W
P
---
G
-
N
ELIYKGICPS
C
-------
L
P
T
T
E
C
L
K
D
T
V
E
R
V
K
P
Y
F
E
D
V
I
A
P
S
I
M
S
G
K
S
V
L
V
S
A
H
G
N
S
L
R
A
L
L
Y
L
L
E
G
M
T
P
E
Q
I
L
E
V
N
I
P
T
A
C
P
L
V
L
E
L
D
D
Y
L
K
V
T
K
----
100
HHSearch
80.43
47%
5
- C1 -
-
5UM0
1
GPMA_NEIG2
D:
[9-234]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
-----
L
L
-----
D
K
D
D
A------
F
----
S
------
A
HKDR--
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
F
Y
-
102
HHSearch
80.21
44%
-4
- C- -
-
3KKK
-
?
C:
[4-226]
Y
T
L
V
L
L
R
H
G
E
S
T
W
N
K
E
N
K
F
T
G
W
T
D
V
P
L
S
E
K
G
E
E
E
A
I
A
A
G
K
Y
L
K
E
K
N
F
K
F
D
V
V
Y
T
S
V
L
K
R
A
I
C
T
A
W
N
V
L
K
T
A
D
L
L
H
V
P
V
V
K
T
W
R
L
N
E
R
H
C
G
S
L
Q
G
L
N
K
S
E
T
A
K
K
Y
G
E
E
Q
V
K
I
W
R
R
S
Y
-------
D
I
P
P
P
-----
K
L
-----
D
K
E
D
NRWPG--
H
----
N
------
V
------
V
Y
K
--
N
V
P
---
K
-
D
----------
A
-------
L
P
F
T
E
C
L
K
D
T
V
E
R
V
L
P
F
W
F
D
H
I
A
P
D
I
L
A
N
K
K
V
M
V
A
A
H
G
N
S
L
R
G
L
V
K
H
L
D
N
L
S
E
A
D
V
L
E
L
N
I
P
T
G
V
P
L
V
Y
E
L
D
E
N
L
K
P
I
K
----
117
HHSearch
80.00
38%
-16
- C1 -
-
2H4Z
1
PMGE_HUMAN
A:
[4-229]
Y
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
PIEES
H
P
-----
Y
Y
Q
E
I------
Y
----
N
------
D
------
R
R
Y
--
K
V
C
DVP
L
-
D
----------
Q
-------
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
R
A
V
-----
21
PsiBlast_CBE
79.57
47%
8
- C1 -
-
5UM0
1
GPMA_NEIG2
D:
[9-232]
M
E
L
V
F
I
R
H
G
Q
S
E
W
N
A
K
N
L
F
T
G
W
R
D
V
K
L
S
E
Q
G
L
A
E
A
A
A
A
G
K
K
L
K
E
N
G
Y
E
F
D
I
A
F
T
S
V
L
T
R
A
I
K
T
C
N
I
V
L
E
E
S
D
Q
L
F
V
P
Q
I
K
T
W
R
L
N
E
R
H
Y
G
R
L
Q
G
L
D
K
K
Q
T
A
E
K
Y
G
D
E
Q
V
R
I
W
R
R
S
Y
-------
D
T
L
P
P
L----
L
D
-----
K
D
D
A
-------
F
SAHK
D
------
R
------
R
Y
A
--
H
L
P
---
A
-
D
----------
V
-------
V
P
D
G
E
N
L
K
V
T
L
E
R
V
L
P
F
W
E
D
Q
I
A
P
A
I
L
S
G
K
R
V
L
V
A
A
H
G
N
S
L
R
A
L
A
K
H
I
E
G
I
S
D
E
D
I
M
G
L
E
I
P
T
G
Q
P
L
V
Y
K
L
D
D
N
L
K
V
I
E
K
---
79
PsiBlast_CBE
79.30
41%
-15
- C1 -
-
1RII
1
GPMA_MYCTU
A:
[6-217]
-
S
L
V
L
L
R
H
G
E
S
D
W
N
A
L
N
L
F
T
G
W
V
D
V
G
L
T
D
K
G
Q
A
E
A
V
R
S
G
E
L
I
A
E
H
D
L
L
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
H
L
A
L
D
S
A
D
R
L
W
I
P
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
E
T
K
A
R
Y
G
E
E
Q
F
M
A
W
R
R
S
Y
D------
T
P
P
P
P
-----
I
E
-----
R
G
S
Q
-------
F
----
S
------
Q
------
D
A
D
PR
Y
A
D
---
I
-
G
----------
G
-------
G
P
L
T
E
C
L
A
D
V
V
A
R
F
L
P
Y
F
T
D
V
I
V
G
D
L
R
V
G
K
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
Q
M
S
D
D
E
I
V
G
L
N
I
P
T
G
I
P
L
R
Y
D
L
------------
8
PsiBlast_PDB
79.09
41%
4
- C1 -
-
1BQ3
1
PMG1_YEAST
D:
[2-219]
-
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
D------
V
P
P
P
P
-----
I
D
-----
A
S
S
P
-------
F
SQKG
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
--------
63
PsiBlast_CBE
79.05
40%
-13
- C1 -
-
2H4Z
1
PMGE_HUMAN
B:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
25
PsiBlast_CBE
78.96
41%
8
- C1 -
-
1QHF
1
PMG1_YEAST
B:
[2-219]
-
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
D------
V
P
P
P
P
-----
I
D
-----
A
S
S
P
-------
F
SQKG
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
--------
66
PsiBlast_CBE
78.40
40%
-16
- C1 -
-
2H4X
1
PMGE_HUMAN
A:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
108
HHSearch
77.96
39%
-14
- C1 -
-
1RII
1
GPMA_MYCTU
A:
[5-225]
G
S
L
V
L
L
R
H
G
E
S
D
W
N
A
L
N
L
F
T
G
W
V
D
V
G
L
T
D
K
G
Q
A
E
A
V
R
S
G
E
L
I
A
E
H
D
L
L
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
H
L
A
L
D
S
A
D
R
L
W
I
P
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
E
T
K
A
R
Y
G
E
E
Q
F
M
A
W
R
R
S
Y
-------
D
T
P
P
P
-----
P
I
-----
E
R
G
S
QF-----
S
----
Q
------
D
------
A
D
P
--
R
Y
A
---
D
I
G
----------
G
-------
G
P
L
T
E
C
L
A
D
V
V
A
R
F
L
P
Y
F
T
D
V
I
V
G
D
L
R
V
G
K
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
Q
M
S
D
D
E
I
V
G
L
N
I
P
T
G
I
P
L
R
Y
D
L
D
S
A
M
R
P
L
V
----
76
PsiBlast_CBE
77.84
41%
-12
- C1 -
-
1RII
3
GPMA_MYCTU
D:
[6-217]
-
S
L
V
L
L
R
H
G
E
S
D
W
N
A
L
N
L
F
T
G
W
V
D
V
G
L
T
D
K
G
Q
A
E
A
V
R
S
G
E
L
I
A
E
H
D
L
L
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
H
L
A
L
D
S
A
D
R
L
W
I
P
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
E
T
K
A
R
Y
G
E
E
Q
F
M
A
W
R
R
S
Y
D------
T
P
P
P
P
-----
I
E
-----
R
G
S
Q
-------
F
----
S
------
Q
------
D
A
D
PR
Y
A
D
---
I
-
G
----------
G
-------
G
P
L
T
E
C
L
A
D
V
V
A
R
F
L
P
Y
F
T
D
V
I
V
G
D
L
R
V
G
K
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
Q
M
S
D
D
E
I
V
G
L
N
I
P
T
G
I
P
L
R
Y
D
L
------------
64
PsiBlast_CBE
77.82
40%
-16
- C1 -
-
2H4Z
1
PMGE_HUMAN
A:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
18
PsiBlast_PDB
77.44
41%
9
- C1 -
-
1YFK
1
PGAM1_HUMAN
A:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
78
PsiBlast_CBE
77.42
41%
-11
* C1 *
-
1RII
1
GPMA_MYCTU
B:
[6-217]
-
S
L
V
L
L
R
H
G
E
S
D
W
N
A
L
N
L
F
T
G
W
V
D
V
G
L
T
D
K
G
Q
A
E
A
V
R
S
G
E
L
I
A
E
H
D
L
L
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
H
L
A
L
D
S
A
D
R
L
W
I
P
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
E
T
K
A
R
Y
G
E
E
Q
F
M
A
W
R
R
S
Y
D------
T
P
P
P
P
-----
I
E
-----
R
G
S
Q
-------
F
----
S
------
Q
------
D
A
D
PR
Y
A
D
---
I
-
G
----------
G
-------
G
P
L
T
E
C
L
A
D
V
V
A
R
F
L
P
Y
F
T
D
V
I
V
G
D
L
R
V
G
K
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
Q
M
S
D
D
E
I
V
G
L
N
I
P
T
G
I
P
L
R
Y
D
L
------------
35
PsiBlast_CBE
77.40
41%
7
- C1 -
-
1BQ4
1
PMG1_YEAST
A:
[2-219]
-
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
D------
V
P
P
P
P
-----
I
D
-----
A
S
S
P
-------
F
SQKG
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
--------
58
PsiBlast_CBE
77.21
41%
7
- C1 -
-
1YFK
1
PGAM1_HUMAN
B:
[5-224]
-
K
L
V
L
I
R
H
G
E
S
A
W
N
L
E
N
R
F
S
G
W
Y
D
A
D
L
S
P
A
G
H
E
E
A
K
R
G
G
Q
A
L
R
D
A
G
Y
E
F
D
I
C
F
T
S
V
Q
K
R
A
I
R
T
L
W
T
V
L
D
A
I
D
Q
M
W
L
P
V
V
R
T
W
R
L
N
E
R
H
Y
G
G
L
T
G
L
N
K
A
E
T
A
A
K
H
G
E
A
Q
V
K
I
W
R
R
S
Y
DVPPPPM
E
P
D
H
P
-----
F
Y
-----
S
N
I
S
-------
K
----
D
------
R
------
R
Y
A
--
D
L
T
---
E
-
D
----------
Q
-------
L
P
S
C
E
S
L
K
D
T
I
A
R
A
L
P
F
W
N
E
E
I
V
P
Q
I
K
E
G
K
R
V
L
I
A
A
H
G
N
S
L
R
G
I
V
K
H
L
E
G
L
S
E
E
A
I
M
E
L
N
L
P
T
G
I
P
I
V
Y
E
L
D
K
N
L
--------
109
HHSearch
77.18
39%
-12
- C1 -
-
1RII
1
GPMA_MYCTU
B:
[5-225]
G
S
L
V
L
L
R
H
G
E
S
D
W
N
A
L
N
L
F
T
G
W
V
D
V
G
L
T
D
K
G
Q
A
E
A
V
R
S
G
E
L
I
A
E
H
D
L
L
P
D
V
L
Y
T
S
L
L
R
R
A
I
T
T
A
H
L
A
L
D
S
A
D
R
L
W
I
P
V
R
R
S
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
D
K
A
E
T
K
A
R
Y
G
E
E
Q
F
M
A
W
R
R
S
Y
-------
D
T
P
P
P
-----
P
I
-----
E
R
G
S
QF-----
S
----
Q
------
D
------
A
D
P
--
R
Y
A
---
D
I
G
----------
G
-------
G
P
L
T
E
C
L
A
D
V
V
A
R
F
L
P
Y
F
T
D
V
I
V
G
D
L
R
V
G
K
T
V
L
I
V
A
H
G
N
S
L
R
A
L
V
K
H
L
D
Q
M
S
D
D
E
I
V
G
L
N
I
P
T
G
I
P
L
R
Y
D
L
D
S
A
M
R
P
L
V
----
2
PsiBlast_PDB
77.17
45%
13
- C1 -
-
1E59
1
GPMA_ECOLI
A:
[4-229]
-
K
L
V
L
V
R
H
G
E
S
Q
W
N
K
E
N
R
F
T
G
W
Y
D
V
D
L
S
E
K
G
V
S
E
A
K
A
A
G
K
L
L
K
E
E
G
Y
S
F
D
F
A
Y
T
S
V
L
K
R
A
I
H
T
L
W
N
V
L
D
E
L
D
Q
A
W
L
P
V
E
K
S
W
K
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
A
E
T
A
E
K
Y
G
D
E
Q
V
K
Q
W
R
R
G
F
-------
A
V
T
P
P
E
----
L
T
-----
K
D
D
E
RYPG---
H
----
D
------
P
------
R
Y
A
--
K
L
S
---
E
-
K
----------
E
-------
L
P
L
T
E
S
L
A
L
T
I
D
R
V
I
P
Y
W
N
E
T
I
L
P
R
M
K
S
G
E
R
V
I
I
A
A
H
G
N
S
L
R
A
L
V
K
Y
L
D
N
M
S
E
E
E
I
L
E
L
N
I
P
T
G
V
P
L
V
Y
E
F
D
E
N
F
K
P
L
K
R
Y
Y
L
68
PsiBlast_CBE
77.08
40%
-11
- C1 -
-
2F90
1
PMGE_HUMAN
A:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
67
PsiBlast_CBE
76.93
40%
-14
- C1 -
-
2F90
1
PMGE_HUMAN
B:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
17
PsiBlast_PDB
76.69
43%
8
- C1 -
-
4EMB
1
GPMA_BORBU
A:
[29-247]
-
K
L
V
L
V
R
H
G
E
S
E
W
N
K
E
N
L
F
T
G
W
T
D
V
K
L
S
D
K
G
I
D
E
A
V
E
A
G
L
L
L
K
Q
E
G
Y
S
F
D
I
A
F
S
S
L
L
S
R
A
N
D
T
L
N
I
I
L
R
E
L
G
Q
S
Y
I
S
V
K
K
T
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
S
E
T
A
A
K
Y
G
E
D
K
V
L
I
W
R
R
S
Y
--------
D
V
P
P
-----
M
S
-----
L
D
E
S
-------
D
----
D
------
R
HPIKDP
R
Y
K
--
H
I
P
---
K
-
R
----------
E
-------
L
P
S
T
E
C
L
K
D
T
V
A
R
V
I
P
Y
W
T
D
E
I
A
K
E
V
L
E
G
K
K
V
I
V
A
A
H
G
N
S
L
R
A
L
V
K
Y
F
D
N
L
S
E
E
D
V
L
K
L
N
I
P
T
G
I
P
L
V
Y
E
L
D
K
D
L
N
-------
69
PsiBlast_CBE
76.62
40%
-12
- C1 -
-
2A9J
1
PMGE_HUMAN
B:
[5-226]
-
K
L
I
M
L
R
H
G
E
G
A
W
N
K
E
N
R
F
C
S
W
V
D
Q
K
L
N
S
E
G
M
E
E
A
R
N
C
G
K
Q
L
K
A
L
N
F
E
F
D
L
V
F
T
S
V
L
N
R
S
I
H
T
A
W
L
I
L
E
E
L
G
Q
E
W
V
P
V
E
S
S
W
R
L
N
E
R
H
Y
G
A
L
I
G
L
N
R
E
Q
M
A
L
N
H
G
E
E
Q
V
R
L
W
R
R
S
Y
-------
N
V
T
P
P
-----
P
I
-----
E
E
S
H
PYYQEIY
N
----
D
------
R
------
R
Y
K
--
V
C
D
---
V
-
P
----------
L
DQ-----
L
P
R
S
E
S
L
K
D
V
L
E
R
L
L
P
Y
W
N
E
R
I
A
P
E
V
L
R
G
K
T
I
L
I
S
A
H
G
N
S
S
R
A
L
L
K
H
L
E
G
I
S
D
E
D
I
I
N
I
T
L
P
T
G
V
P
I
L
L
E
L
D
E
N
L
--------
119
HHSearch
76.37
43%
-1
- C1 -
-
4EMB
1
GPMA_BORBU
A:
[28-250]
Y
K
L
V
L
V
R
H
G
E
S
E
W
N
K
E
N
L
F
T
G
W
T
D
V
K
L
S
D
K
G
I
D
E
A
V
E
A
G
L
L
L
K
Q
E
G
Y
S
F
D
I
A
F
S
S
L
L
S
R
A
N
D
T
L
N
I
I
L
R
E
L
G
Q
S
Y
I
S
V
K
K
T
W
R
L
N
E
R
H
Y
G
A
L
Q
G
L
N
K
S
E
T
A
A
K
Y
G
E
D
K
V
L
I
W
R
R
S
Y
-------
D
V
P
P
M
-----
S
L
D
ESDD
R
H
P
I
-------
K
----
D
------
P
------
R
Y
K
--
H
I
P
---
K
-
R
----------
E
-------
L
P
S
T
E
C
L
K
D
T
V
A
R
V
I
P
Y
W
T
D
E
I
A
K
E
V
L
E
G
K
K
V
I
V
A
A
H
G
N
S
L
R
A
L
V
K
Y
F
D
N
L
S
E
E
D
V
L
K
L
N
I
P
T
G
I
P
L
V
Y
E
L
D
K
D
L
N
P
I
K
----
104
HHSearch
76.14
41%
9
- C1 -
-
1QHF
1
PMG1_YEAST
B:
[1-224]
P
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
-------
D
V
P
P
P
-----
P
I
DASS-
P
F
S
Q
K------
G
----
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
K
P
S
K
P
---
38
PsiBlast_CBE
75.58
41%
10
- C1 -
-
1BQ3
1
PMG1_YEAST
A:
[2-219]
-
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
D------
V
P
P
P
P
-----
I
D
-----
A
S
S
P
-------
F
SQKG
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
--------
6
PsiBlast_PDB
75.43
41%
10
- C1 -
-
1QHF
1
PMG1_YEAST
A:
[2-219]
-
K
L
V
L
V
R
H
G
Q
S
E
W
N
E
K
N
L
F
T
G
W
V
D
V
K
L
S
A
K
G
Q
Q
E
A
A
R
A
G
E
L
L
K
E
K
K
V
Y
P
D
V
L
Y
T
S
K
L
S
R
A
I
Q
T
A
N
I
A
L
E
K
A
D
R
L
W
I
P
V
N
R
S
W
R
L
N
E
R
H
Y
G
D
L
Q
G
K
D
K
A
E
T
L
K
K
F
G
E
E
K
F
N
T
Y
R
R
S
F
D------
V
P
P
P
P
-----
I
D
-----
A
S
S
P
-------
F
SQKG
D
------
E
------
R
Y
K
--
Y
V
D
---
P
-
N
----------
V
-------
L
P
E
T
E
S
L
A
L
V
I
D
R
L
L
P
Y
W
Q
D
V
I
A
K
D
L
L
S
G
K
T
V
M
I
A
A
H
G
N
S
L
R
G
L
V
K
H
L
E
G
I
S
D
A
D
I
A
K
L
N
I
P
T
G
I
P
L
V
F
E
L
D
E
N
L
--------
14
PsiBlast_PDB
73.75
45%
-3
- C1 -
-
3GP5
3
GPMA_BURP1
A:
[11-229]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------
15
PsiBlast_PDB
73.55
45%
-4
- C1 -
-
3GW8
4
GPMA_BURP1
A:
[11-229]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------
40
PsiBlast_CBE
73.14
45%
-3
- C1 -
-
3GP5
3
GPMA_BURP1
B:
[11-229]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------
12
PsiBlast_PDB
71.62
45%
-4
- C1 -
-
3FDZ
2
GPMA_BURP1
A:
[11-229]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------
39
PsiBlast_CBE
71.40
45%
-4
- C1 -
-
3GW8
3
GPMA_BURP1
B:
[11-229]
-
K
L
V
L
I
R
H
G
E
S
T
W
N
K
E
N
R
F
T
G
W
V
D
V
D
L
T
E
Q
G
N
R
E
A
R
Q
A
G
Q
L
L
K
E
A
G
Y
T
F
D
I
A
Y
T
S
V
L
K
R
A
I
R
T
L
W
H
V
Q
D
Q
M
D
L
M
Y
V
P
V
V
H
S
W
R
L
N
E
R
H
Y
G
A
L
S
G
L
N
K
A
E
T
A
A
K
Y
G
D
E
Q
V
L
V
W
R
R
S
Y
-------
D
T
P
P
P
------------
A
L
E
P
-------
G
----
D
------
E
------
R
A
P
--
Y
A
D
---
P
-
R
----------
Y
AKVPREQ
L
P
L
T
E
C
L
K
D
T
V
A
R
V
L
P
L
W
N
E
S
I
A
P
A
V
K
A
G
K
Q
V
L
I
A
A
H
G
N
S
L
R
A
L
I
K
Y
L
D
G
I
S
D
A
D
I
V
G
L
N
I
P
N
G
V
P
L
V
Y
E
L
D
E
S
L
T
-------