@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U2S9: (2017-12-23 )
MFNMKESVFQGRSLLAEKDFTKEELQYLIDFSEHLKDLKKRGIPHHYLEGKNIALLFEKTSTRTRSAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQKMVEELAEFSGVPVWNGLTDEWHPTQMIADFLTIQENFGTVEGITVAYCGDGRNNMANSLLVTGAILGANMRIVAPKELQPEEEIVKMAEGFAEKSGAQLMITDDVDKGVDGADVLYSDVWVSMGEEDKFEERIKLLKPYQINMEMVEKTHNTDRLIFLHCLPAFHDTNTVYGEQMKERFGITEMEVTDEVFRSKYARQFDQAENRMHSIKAIMAATLGNLFIPRV
Atome Classification :
(43 SA)
.........10........20........30.....-...40........50.........60........70........80........90........100...-....110.......120.......130-.......140.......150..--.--....160.....---..170.......180.......190.......200.......210.......220.......230.......240-.-...-...250.......260...-...-.-270.......280.......290.....-.-.300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFN
M
K
E
S
V
F
Q
G
R
S
L
LAEKDF
T
K
E
E
L
Q
Y
L
I
D
F
S
E
H
L
K
-
D
L
K
KRGIPHHYLEG-K
N
I
A
L
L
F
EKTSTRTRS
A
F
T
T
A
A
I
DLGAHPEYLGANDIQLGKKES
T
E
D
T
A
K
V
L
G
R
M
-FDGIEFRG
F
S
Q
K
M
V
E
E
L
A
E
FSGVPVWN-GLTDEW
H
P
T
Q
M
I
A
D
F
L
T
I
Q
ENF--G--TVE
G
I
T
V
A
Y
CGD---GRN
N
M
A
N
S
L
L
V
T
G
A
ILGA
N
M
R
I
V
APKELQ
P
E
E
E
I
V
K
M
A
E
G
F
AEKSG
A
Q
L
M
I
TDDVDKGVD
G
A
D
V
L
Y
S
D
V
W
VSMGE-
E
-
D
K
F
-
E
E
R
I
K
LLKPYQI
N
M
E
M
V
E
K-THN-T-
D
R
L
I
F
L
H
CLPAFHDTN
T
V
Y
G
E
Q
M
K
E
R
FG-I-T
E
M
E
V
T
D
E
V
F
R
S
K
Y
A
R
Q
F
D
Q
A
E
N
R
M
H
S
I
K
A
I
M
A
A
T
L
G
NLFIPRV
129
HHSearch
95.29
75%
-70
- C8 -
-
2W37
-
OTCC_LACHI
B:
[22-359]
----
R
Q
N
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
-
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
-
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
--
K
L
Q
G
L
T
L
T
F
M
G
D
---
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
-
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
-
T
G
T
P
D
-
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
-
I
-
T
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
1
PsiBlast_PDB
94.16
73%
-70
- C8 -
-
2W37
-
OTCC_LACHI
A:
[20-359]
--
D
F
R
Q
N
V
F
Q
G
R
S
V
L
A
E
K
D
F
S
A
A
E
L
E
Y
L
I
D
F
G
L
H
L
K
-
A
L
K
K
A
G
I
P
H
H
Y
L
E
G
-
K
N
I
A
L
L
F
E
K
S
S
T
R
T
R
S
A
F
T
T
A
S
I
D
L
G
A
H
P
E
Y
L
G
Q
N
D
I
Q
L
G
K
K
E
S
T
S
D
T
A
K
V
L
G
S
M
-
F
D
G
I
E
F
R
G
F
K
Q
S
D
A
E
I
L
A
R
D
S
G
V
P
V
W
N
-
G
L
T
D
E
W
H
P
T
Q
M
L
A
D
F
M
T
V
K
E
N
F
--
G
--
K
L
Q
G
L
T
L
T
F
M
G
D
---
G
R
N
N
V
A
N
S
L
L
V
T
G
A
I
L
G
V
N
I
H
I
V
A
P
K
A
L
F
P
T
E
E
T
Q
N
I
A
K
G
F
A
E
K
S
G
A
K
L
V
I
T
D
D
L
D
E
G
L
K
G
S
N
V
V
Y
T
D
V
W
V
S
M
G
E
-
S
-
N
-
W
-
E
E
R
V
K
E
L
T
P
Y
Q
V
N
M
E
A
M
K
K
-
T
G
T
-
P
D
D
Q
L
I
F
M
H
C
L
P
A
F
H
N
T
D
T
Q
Y
G
K
E
I
K
E
K
Y
G
-
I
-
T
E
M
E
V
T
D
E
V
F
T
S
K
Y
A
R
Q
F
E
E
A
E
N
R
M
H
S
I
K
A
M
M
A
A
T
L
G
N
L
F
I
P
R
V
141
HHSearch
80.98
44%
-99
- C8 -
-
1A1S
-
OTCA_PYRFU
A:
[3-313]
-------
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
G
K
P
H
R
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
-
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
--
G
--
T
I
K
G
V
K
V
V
Y
V
G
D
---
G
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
-
A
E
A
-
E
E
R
R
K
I
F
R
P
F
Q
V
N
K
D
L
V
K
H
-
A
---
K
-
P
D
Y
M
F
M
H
C
L
P
A
H
R
-------------------
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
----
16
PsiBlast_PDB
79.94
42%
-98
- C8 -
-
1A1S
-
OTCA_PYRFU
A:
[4-312]
--------
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
G
K
P
H
R
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
-
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
--
G
--
T
I
K
G
V
K
V
V
Y
V
G
D
---
G
-
N
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
-
A
E
A
-
E
E
R
R
K
I
F
R
P
F
Q
V
N
K
D
L
V
K
---
H
A
-
K
-
P
D
Y
M
F
M
H
C
L
P
A
H
R
------
G
E
-------------
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
-----
131
HHSearch
79.90
49%
-97
* C8 *
-
1VLV
-
OTC_THEMA
A:
[12-324]
---
H
M
S
V
N
L
K
G
R
S
L
L
T
L
L
D
F
S
P
E
E
I
R
Y
L
L
D
I
S
K
Q
V
K
-
M
E
N
R
S
K
L
R
T
E
R
F
K
G
-
M
T
L
A
M
I
F
E
K
R
S
T
R
T
R
L
A
F
E
T
A
F
A
E
E
G
G
H
P
I
F
L
S
P
N
D
I
H
L
G
A
K
E
S
L
E
D
T
A
R
V
L
G
R
M
-
V
D
A
I
M
F
R
G
Y
K
Q
E
T
V
E
K
L
A
E
Y
S
G
V
P
V
Y
N
-
G
L
T
D
E
F
H
P
T
Q
A
L
A
D
L
M
T
I
E
E
N
F
--
G
--
R
L
K
G
V
K
V
V
F
M
G
D
---
T
R
N
N
V
A
T
S
L
M
I
A
C
A
K
M
G
M
N
F
V
A
C
G
P
E
E
L
K
P
R
S
D
V
F
K
R
C
Q
E
I
V
K
E
T
D
G
S
V
S
F
T
S
N
L
E
E
A
L
A
G
A
D
V
V
Y
T
D
V
W
A
-------------
R
M
A
L
L
K
P
Y
Q
V
N
E
R
V
M
E
M
T
G
---
K
-
S
E
T
I
F
M
H
C
L
P
A
V
K
-------------------
G
Q
E
V
T
Y
E
V
I
E
G
K
Q
S
R
V
W
D
E
A
E
N
R
K
H
T
I
K
A
V
M
I
A
T
L
--------
12
PsiBlast_PDB
79.29
48%
-98
- C8 -
-
1VLV
-
OTC_THEMA
A:
[17-324]
--------
L
K
G
R
S
L
L
T
L
L
D
F
S
P
E
E
I
R
Y
L
L
D
I
S
K
Q
V
K
-
M
E
N
R
S
K
L
R
T
E
R
F
K
G
-
M
T
L
A
M
I
F
E
K
R
S
T
R
T
R
L
A
F
E
T
A
F
A
E
E
G
G
H
P
I
F
L
S
P
N
D
I
H
L
G
A
K
E
S
L
E
D
T
A
R
V
L
G
R
M
-
V
D
A
I
M
F
R
G
Y
K
Q
E
T
V
E
K
L
A
E
Y
S
G
V
P
V
Y
N
-
G
L
T
D
E
F
H
P
T
Q
A
L
A
D
L
M
T
I
E
E
N
F
--
G
--
R
L
K
G
V
K
V
V
F
M
G
D
---
T
R
N
N
V
A
T
S
L
M
I
A
C
A
K
M
G
M
N
F
V
A
C
G
P
E
E
L
K
P
R
S
D
V
F
K
R
C
Q
E
I
V
K
E
T
D
G
S
V
S
F
T
S
N
L
E
E
A
L
A
G
A
D
V
V
Y
T
D
V
W
A
-------------
R
M
A
L
L
K
P
Y
Q
V
N
E
R
V
M
E
M
-
T
G
K
-
S
-
E
-
T
I
F
M
H
C
L
P
A
------
V
K
G
Q
-------------
E
V
T
Y
E
V
I
E
G
K
Q
S
R
V
W
D
E
A
E
N
R
K
H
T
I
K
A
V
M
I
A
T
L
--------
42
PsiBlast_CBE
79.10
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
B:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
36
PsiBlast_CBE
78.96
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
H:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
29
PsiBlast_CBE
78.91
51%
-26
- C8 -
-
4JFR
1
OTC_VIBVU
C:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
137
HHSearch
78.67
43%
-98
- C8 -
-
1PVV
-
OTCA_PYRFU
A:
[2-314]
-----
V
V
S
L
A
G
R
D
L
L
C
L
Q
D
Y
T
A
E
E
I
W
T
I
L
E
T
A
K
M
F
K
-
I
W
Q
K
I
G
K
P
H
R
L
L
E
G
-
K
T
L
A
M
I
F
Q
K
P
S
T
R
T
R
V
S
F
E
V
A
M
A
H
L
G
G
H
A
L
Y
L
N
A
Q
D
L
Q
L
R
R
G
E
T
I
A
D
T
A
R
V
L
S
R
Y
-
V
D
A
I
M
A
R
V
Y
D
H
K
D
V
E
D
L
A
K
Y
A
T
V
P
V
I
N
-
G
L
S
D
F
S
H
P
C
Q
A
L
A
D
Y
M
T
I
W
E
K
K
--
G
--
T
I
K
G
V
K
V
V
Y
V
G
D
---
G
N
-
N
V
A
H
S
L
M
I
A
G
T
K
L
G
A
D
V
V
V
A
T
P
E
G
Y
E
P
D
E
K
V
I
K
W
A
E
Q
N
A
A
E
S
G
G
S
F
E
L
L
H
D
P
V
K
A
V
K
D
A
D
V
I
Y
T
D
V
W
A
S
M
G
Q
-
E
-
A
E
A
-
E
E
R
R
K
I
F
R
P
F
Q
V
N
K
D
L
V
K
H
-
A
---
K
-
P
D
Y
M
F
M
H
C
L
P
A
H
R
-------------------
G
E
E
V
T
D
D
V
I
D
S
P
N
S
V
V
W
D
Q
A
E
N
R
L
H
A
Q
K
A
V
L
A
L
V
M
G
G
I
K
----
10
PsiBlast_PDB
78.65
52%
-31
- C8 -
-
1DUV
3
OTC1_ECOLI
G:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
140
HHSearch
78.62
42%
-96
- C8 -
-
4NF2
3
OTC_BACAN
A:
[30-335]
-----
V
P
K
L
N
T
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
----
Q
E
P
L
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
-
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
--
T
F
K
G
I
K
L
A
Y
V
G
D
---
G
N
-
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
E
--
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
H
-
A
---
K
-
Q
T
Y
H
F
L
H
C
L
P
A
H
R
-------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
5
PsiBlast_PDB
78.50
51%
-20
- C8 -
-
4JHX
2
OTC_VIBVU
A:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
33
PsiBlast_CBE
78.42
52%
-29
- C8 -
-
1DUV
2
OTC1_ECOLI
I:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
38
PsiBlast_CBE
78.36
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
F:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
37
PsiBlast_CBE
78.36
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
G:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
39
PsiBlast_CBE
78.32
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
E:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
30
PsiBlast_CBE
78.24
51%
-20
- C8 -
-
4JFR
2
OTC_VIBVU
B:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
41
PsiBlast_CBE
78.18
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
C:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
40
PsiBlast_CBE
78.12
52%
-29
- C8 -
-
2OTC
2
OTC1_ECOLI
D:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
R
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
4
PsiBlast_PDB
78.07
51%
-19
- C8 -
-
4JFR
1
OTC_VIBVU
A:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
26
PsiBlast_CBE
77.98
51%
-19
- C8 -
-
4JQO
3
OTC_VIBVU
B:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
34
PsiBlast_CBE
77.96
52%
-28
- C8 -
-
1DUV
2
OTC1_ECOLI
H:
[1-331]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
PG
K
--
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
A
K
-
E
K
W
-
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
-
T
G
N
-
P
-
E
-
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
-
L
H
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
--------
25
PsiBlast_CBE
77.89
51%
-18
- C8 -
-
4JQO
3
OTC_VIBVU
C:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
32
PsiBlast_CBE
77.49
51%
-18
- C8 -
-
4H31
10
OTC_VIBVU
B:
[29-357]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
3
PsiBlast_PDB
77.45
51%
-23
- C8 -
-
4H31
12
OTC_VIBVU
A:
[29-357]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
-------
6
PsiBlast_PDB
77.37
51%
-19
- C8 -
-
4JQO
5
OTC_VIBVU
A:
[29-358]
--------
L
R
N
R
N
F
L
K
L
L
D
F
S
T
K
E
I
Q
F
L
I
D
L
S
A
D
L
K
-
K
A
K
Y
A
G
T
E
Q
K
K
L
L
G
-
K
N
I
A
L
I
F
E
K
A
S
T
R
T
R
C
A
F
E
V
A
A
F
D
Q
G
A
Q
V
T
Y
I
G
P
S
G
S
Q
I
G
D
K
E
S
M
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
F
G
Q
A
I
V
E
E
L
G
A
F
A
G
V
P
V
W
N
-
G
L
T
D
E
F
H
P
T
Q
I
L
A
D
F
L
T
M
L
E
H
S
QG
K
--
A
L
A
D
I
Q
F
A
Y
L
G
D
---
A
R
N
N
V
G
N
S
L
M
V
G
A
A
K
M
G
M
D
I
R
L
V
G
P
Q
A
Y
W
P
D
E
E
L
V
A
A
C
Q
A
I
A
K
Q
T
G
G
K
I
T
L
T
E
N
V
A
E
G
V
Q
G
C
D
F
L
Y
T
D
V
W
V
S
M
G
E
-
S
P
E
A
W
-
D
E
R
V
A
L
M
K
P
Y
Q
V
N
M
N
V
L
K
Q
-
T
G
N
-
P
-
N
-
V
K
F
M
H
C
L
P
A
F
H
N
D
E
T
T
I
G
K
Q
V
A
D
K
F
G
-
M
-
K
G
L
E
V
T
E
E
V
F
E
S
E
H
S
I
V
F
D
E
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
G
S
------
43
PsiBlast_CBE
76.99
40%
-95
- C8 -
-
4NF2
3
OTC_BACAN
C:
[36-335]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
-
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
--
T
F
K
G
I
K
L
A
Y
V
G
D
---
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
-
Y
H
--
F
L
H
C
L
P
A
H
R
-------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
18
PsiBlast_PDB
76.94
40%
-94
- C8 -
-
4NF2
3
OTC_BACAN
A:
[36-335]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
-
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
--
T
F
K
G
I
K
L
A
Y
V
G
D
---
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
-
Y
H
--
F
L
H
C
L
P
A
H
R
-------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
130
HHSearch
76.74
52%
-18
- C8 -
-
1DUV
2
OTC1_ECOLI
H:
[1-333]
------
S
G
F
Y
H
K
H
F
L
K
L
L
D
F
T
P
A
E
L
N
S
L
L
Q
L
A
A
K
L
K
-
A
D
K
K
S
G
K
E
E
A
K
L
T
G
-
K
N
I
A
L
I
F
E
K
D
S
T
R
T
R
C
S
F
E
V
A
A
Y
D
Q
G
A
R
V
T
Y
L
G
P
S
G
S
Q
I
G
H
K
E
S
I
K
D
T
A
R
V
L
G
R
M
-
Y
D
G
I
Q
Y
R
G
Y
G
Q
E
I
V
E
T
L
A
E
Y
A
S
V
P
V
W
N
-
G
L
T
N
E
F
H
P
T
Q
L
L
A
D
L
L
T
M
Q
E
H
L
--
P
GK
A
F
N
E
M
T
L
V
Y
A
G
D
---
A
R
N
N
M
G
N
S
M
L
E
A
A
A
L
T
G
L
D
L
R
L
V
A
P
Q
A
C
W
P
E
A
A
L
V
T
E
C
R
A
L
A
Q
Q
N
G
G
N
I
T
L
T
E
D
V
A
K
G
V
E
G
A
D
F
I
Y
T
D
V
W
V
S
M
G
E
-
A
-
K
E
K
W
A
E
R
I
A
L
L
R
E
Y
Q
V
N
S
K
M
M
Q
L
T
G
---
N
-
P
E
V
K
F
L
H
C
L
P
A
F
H
D
D
Q
T
T
L
G
K
K
M
A
E
E
F
G
L
H
-
G
G
M
E
V
T
D
E
V
F
E
S
A
A
S
I
V
F
D
Q
A
E
N
R
M
H
T
I
K
A
V
M
V
A
T
L
S
K
------
44
PsiBlast_CBE
76.61
40%
-94
- C8 -
-
4NF2
3
OTC_BACAN
B:
[36-335]
-----------
K
D
L
L
T
L
E
E
L
T
Q
E
E
I
I
S
L
I
E
F
A
I
Y
L
K
-
K
N
K
Q
E
P
L
----
L
Q
G
-
K
I
L
G
L
I
F
D
K
H
S
T
R
T
R
V
S
F
E
A
G
M
V
Q
L
G
G
H
G
M
F
L
N
G
K
E
M
Q
M
Q
R
G
E
T
V
S
D
T
A
K
V
L
S
H
Y
-
I
D
G
I
M
I
R
T
F
S
H
A
D
V
E
E
L
A
K
E
S
S
I
P
V
I
N
-
G
L
T
D
D
H
H
P
C
Q
A
L
A
D
L
M
T
I
Y
E
E
T
--
N
--
T
F
K
G
I
K
L
A
Y
V
G
D
---
G
-
N
N
V
C
H
S
L
L
L
A
S
A
K
V
G
M
H
M
T
V
A
T
P
V
G
Y
R
P
N
E
E
I
V
K
K
A
L
A
I
A
K
E
T
G
A
E
I
E
I
L
H
N
P
E
L
A
V
N
E
A
D
F
I
Y
T
D
V
W
M
S
M
G
Q
-
E
-
G
E
--
E
E
K
Y
T
L
F
Q
P
Y
Q
I
N
K
E
L
V
K
H
-
A
K
Q
-
T
-
Y
H
--
F
L
H
C
L
P
A
H
R
-------------------
E
E
E
V
T
G
E
I
I
D
G
P
Q
S
I
V
F
E
Q
A
G
N
R
L
H
A
Q
K
A
L
L
V
S
L
F
K
N
------
19
PsiBlast_PDB
65.27
37%
-18
- C8 -
-
1OTH
1
OTC_HUMAN
A:
[4-309]
--------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
-
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
--
S
L
K
G
L
T
L
S
W
I
G
D
---
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
-
T
A
K
-
V
A
A
-
S
-
D
-
W
T
F
L
H
C
L
P
R
K
P
E
--------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--------
20
PsiBlast_PDB
65.26
37%
-16
- C8 -
-
1C9Y
2
OTC_HUMAN
A:
[4-309]
--------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
-
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
--
S
L
K
G
L
T
L
S
W
I
G
D
---
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
-
T
A
K
-
V
A
A
-
S
-
D
-
W
T
F
L
H
C
L
P
R
K
P
E
--------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--------
47
PsiBlast_CBE
65.09
37%
-18
- C8 -
-
1EP9
1
OTC_HUMAN
A:
[4-309]
--------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
-
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
--
S
L
K
G
L
T
L
S
W
I
G
D
---
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
-
T
A
K
-
V
A
A
-
S
-
D
-
W
T
F
L
H
C
L
P
R
K
P
E
--------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--------
142
HHSearch
64.68
37%
-12
- C8 -
-
2I6U
3
OTC_MYCTU
C:
[2-306]
----------
I
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
A
E
L
K
-
K
D
P
V
---
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
-
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
--
A
L
R
G
L
R
L
S
Y
F
G
D
---
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
-
A
---
D
-
S
D
A
I
V
L
H
C
L
P
A
H
R
-------------------
G
D
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
V
W
L
L
E
R
------
46
PsiBlast_CBE
64.44
37%
-19
- C8 -
-
1FVO
1
OTC_HUMAN
A:
[4-309]
--------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
-
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
--
S
L
K
G
L
T
L
S
W
I
G
D
---
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
-
T
A
K
-
V
A
A
-
S
-
D
-
W
T
F
L
H
C
L
P
R
K
P
E
--------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--------
55
PsiBlast_CBE
64.01
35%
-13
- C8 -
-
2I6U
4
OTC_MYCTU
B:
[3-300]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
-
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
--
A
L
R
G
L
R
L
S
Y
F
G
D
---
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
---
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
45
PsiBlast_CBE
63.99
37%
-16
- C8 -
-
1FVO
1
OTC_HUMAN
B:
[4-309]
--------
L
K
G
R
D
L
L
T
L
K
N
F
T
G
E
E
I
K
Y
M
L
W
L
S
A
D
L
K
F
R
I
K
Q
K
G
E
Y
L
P
L
L
Q
G
-
K
S
L
G
M
I
F
E
K
R
S
T
R
T
R
L
S
T
E
T
G
F
A
L
L
G
G
H
P
C
F
L
T
T
Q
D
I
H
L
G
V
N
E
S
L
T
D
T
A
R
V
L
S
S
M
-
A
D
A
V
L
A
R
V
Y
K
Q
S
D
L
D
T
L
A
K
E
A
S
I
P
I
I
N
-
G
L
S
D
L
Y
H
P
I
Q
I
L
A
D
Y
L
T
L
Q
E
H
Y
--
S
--
S
L
K
G
L
T
L
S
W
I
G
D
---
G
-
N
N
I
L
H
S
I
M
M
S
A
A
K
F
G
M
H
L
Q
A
A
T
P
K
G
Y
E
P
D
A
S
V
T
K
L
A
E
Q
Y
A
K
E
N
G
T
K
L
L
L
T
N
D
P
L
E
A
A
H
G
G
N
V
L
I
T
D
T
W
I
S
M
G
R
-
E
-
E
E
K
-
K
K
R
L
Q
A
F
Q
G
Y
Q
V
T
M
K
-
T
A
K
-
V
A
A
-
S
-
D
-
W
T
F
L
H
C
L
P
R
K
P
E
--------------------
E
V
D
D
E
V
F
Y
S
P
R
S
L
V
F
P
E
A
E
N
R
K
W
T
I
M
A
V
M
V
S
L
L
--------
54
PsiBlast_CBE
63.16
35%
-7
- C8 -
-
2I6U
3
OTC_MYCTU
C:
[3-300]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
-
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
--
A
L
R
G
L
R
L
S
Y
F
G
D
---
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
---
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
56
PsiBlast_CBE
61.89
35%
-9
- C8 -
-
2I6U
3
OTC_MYCTU
A:
[3-300]
-----------
R
H
F
L
R
D
D
D
L
S
P
A
E
Q
A
E
V
L
E
L
A
---
A
-
E
L
K
K
D
P
V
S
R
R
P
L
Q
G
P
R
G
V
A
V
I
F
D
K
N
S
T
R
T
R
F
S
F
E
L
G
I
A
Q
L
G
G
H
A
V
V
V
D
S
G
S
T
Q
L
G
R
D
E
T
L
Q
D
T
A
K
V
L
S
R
Y
-
V
D
A
I
V
W
R
T
F
G
Q
E
R
L
D
A
M
A
S
V
A
T
V
P
V
I
N
-
A
L
S
D
E
F
H
P
C
Q
V
L
A
D
L
Q
T
I
A
E
R
K
--
G
--
A
L
R
G
L
R
L
S
Y
F
G
D
---
G
A
N
N
M
A
H
S
L
L
L
G
G
V
T
A
G
I
H
V
T
V
A
A
P
E
G
F
L
P
D
P
S
V
R
A
A
A
E
R
R
A
Q
D
T
G
A
S
V
T
V
T
A
D
A
H
A
A
A
A
G
A
D
V
L
V
T
D
T
W
T
S
M
G
Q
-
E
-
N
D
G
-
L
D
R
V
K
P
F
R
P
F
Q
L
N
S
R
L
L
A
L
-
A
D
S
-
D
---
A
I
V
L
H
C
L
P
A
H
R
G
D
-------------------
E
I
T
D
A
V
M
D
G
P
A
S
A
V
W
D
E
A
E
N
R
L
H
A
Q
K
A
L
L
------------
118
PsiBlast_CBE
43.06
32%
-5
- C8 -
-
3R7F
1
PYRB_BACSU
A:
[2-188]
-----------
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
-
S
----
G
K
T
D
N
Q
L
T
G
-
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
--
N
--
T
F
K
G
L
T
V
S
I
H
G
D
IKH
S
R
V
A
R
S
N
A
E
V
L
T
R
--
L
G
A
R
V
L
F
S
G
P
S
E
W
Q
D
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
117
PsiBlast_CBE
41.98
32%
-5
- C8 -
-
3R7F
3
PYRB_BACSU
B:
[2-188]
-----------
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
-
S
----
G
K
T
D
N
Q
L
T
G
-
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
--
N
--
T
F
K
G
L
T
V
S
I
H
G
D
IKH
S
R
V
A
R
S
N
A
E
V
L
T
R
--
L
G
A
R
V
L
F
S
G
P
S
E
W
Q
D
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
116
PsiBlast_CBE
41.37
32%
-1
- C8 -
-
3R7F
1
PYRB_BACSU
C:
[2-188]
-----------
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
E
L
K
-
S
----
G
K
T
D
N
Q
L
T
G
-
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
D
G
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
L
V
S
Q
V
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
--
N
--
T
F
K
G
L
T
V
S
I
H
G
D
IKH
S
R
V
A
R
S
N
A
E
V
L
T
R
--
L
G
A
R
V
L
F
S
G
P
S
E
W
Q
D
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------