@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3U3R3: (2017-12-25 )
MIEMKDVMKKYSNGTTAIRNLSIVIEQGEFVYVVGPSGAGKSTFIKLMYREEKASKGTLNVAGHDLIAIKNREVPYLRREIGVVFQDYKLLPRKTVYENVAYAMQVIGRKPRDIKKRVMEVLDLVGLKHKVRVFPSELSGGEQQRVSIARAIVNTPKVLIADEPTGNLDPENSWEIMKLLDRINAQGTTVVMATHNSTIVNTIRHRVIAIENGRIIRDQAEGEYGYDD
Atome Classification :
(25 SA)
.........10...---.---.---...20........30........40........50........---60.....-...70........80.........90.....-----------...100.......---110.......120.......130..-.....140.......150.......160.......170.......180...-.-...190.......200..--.....210.......220......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MI
E
M
K
D
V
M
K
K
YSNG---T---
T
---
A
I
R
N
L
S
I
V
I
EQG
E
F
V
Y
V
VGPSGA
G
K
S
T
F
I
K
L
M
Y
REEKASKG
T
L
---NVAG
H
D
L
-
I
A
I
KNREV
P
Y
L
R
R
E
-
I
G
V
V
F
Q
D
Y
KLL
P
R
K
T
V
-----------
Y
E
N
V
A
Y
A
M
Q
V
IGR---K
P
R
D
I
K
K
R
V
M
E
V
L
D
L
VGLK
H
K
V
R
VF-
P
S
ELSGG
E
Q
Q
R
V
S
I
A
R
A
I
VNTP
K
V
L
I
ADEPTGNLDPE
N
S
W
E
I
M
K
L
L
D
R
INA-Q-G
T
T
V
V
M
ATHN
S
T
I
V
N
T
I
R
--
H
R
V
I
A
IEN
G
R
I
I
R
DQAEGEYGYDD
11
PsiBlast_PDB
81.15
37%
0
- C- -
-
5NIL
-
?
J:
[4-243]
L
L
E
L
K
D
I
R
R
S
Y
P
A
G
DEQ
V
---
E
---
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
---
R
V
A
G
Q
D
V
-
A
T
L
D
A
D
A
L
A
Q
L
R
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
-----------
E
Q
N
V
E
V
P
A
V
Y
A
G
L
---
E
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
R
L
G
L
E
D
R
T
E
Y
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
D
-
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
--
E
R
V
I
E
I
R
D
G
E
I
V
R
N
----------
10
PsiBlast_PDB
81.15
37%
0
- C- -
-
5NIK
-
?
J:
[4-243]
L
L
E
L
K
D
I
R
R
S
Y
P
A
G
DEQ
V
---
E
---
V
L
K
G
I
S
L
D
I
Y
A
G
E
M
V
A
I
V
G
A
S
G
S
G
K
S
T
L
M
N
I
L
G
C
L
D
K
A
T
S
G
T
Y
---
R
V
A
G
Q
D
V
-
A
T
L
D
A
D
A
L
A
Q
L
R
R
E
H
F
G
F
I
F
Q
R
Y
H
L
L
S
H
L
T
A
-----------
E
Q
N
V
E
V
P
A
V
Y
A
G
L
---
E
R
K
Q
R
L
L
R
A
Q
E
L
L
Q
R
L
G
L
E
D
R
T
E
Y
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
M
N
G
G
Q
V
I
L
A
D
E
P
T
G
A
L
D
S
H
S
G
E
E
V
M
A
I
L
H
Q
L
R
D
-
R
-
G
H
T
V
I
I
V
T
H
D
P
Q
V
A
A
Q
-
A
--
E
R
V
I
E
I
R
D
G
E
I
V
R
N
----------
136
HHSearch
79.25
38%
-10
- C1 -
-
3TUI
1
METN_ECOLI
C:
[24-251]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
TRT
I
---
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
23
PsiBlast_CBE
78.84
38%
-5
- C1 -
-
3TUZ
1
METN_ECOLI
D:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
2
PsiBlast_PDB
78.07
38%
-6
- C1 -
-
3TUI
1
METN_ECOLI
C:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
3
PsiBlast_PDB
77.84
38%
-4
- C1 -
-
3TUZ
1
METN_ECOLI
C:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
24
PsiBlast_CBE
77.45
38%
-16
- C1 -
-
3TUI
1
METN_ECOLI
H:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
124
HHSearch
77.34
31%
-123
- C1 -
-
2AWN
1
MALK_ECOLI
B:
[3-221]
S
V
Q
L
Q
N
V
T
K
A
W
G
E
----
V
---
V
---
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
---
F
I
G
E
K
R
M
-
N
D
T
-----
P
P
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-----------
A
E
N
M
S
F
G
L
K
L
A
G
A
---
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
-
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
--
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----
25
PsiBlast_CBE
77.21
38%
-20
- C1 -
-
3TUI
1
METN_ECOLI
G:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
22
PsiBlast_CBE
76.85
38%
-9
- C1 -
-
3TUZ
1
METN_ECOLI
G:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
127
HHSearch
76.15
32%
-123
- C1 -
-
4YER
2
?
A:
[5-252]
I
I
V
V
E
N
L
V
K
K
F
G
D
----
F
---
E
---
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
---
W
V
A
G
H
D
V
-
L
K
E
----
P
R
E
V
R
R
K
-
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
-----------
Y
E
N
M
Y
I
H
G
K
I
Y
G
Y
---
G
G
E
K
L
K
K
R
I
L
E
L
L
E
F
V
E
L
L
E
F
K
D
K
P
-
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
--
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
----
20
PsiBlast_PDB
75.96
35%
-111
- C1 -
-
2IT1
-
?
A:
[4-214]
-
I
K
L
E
N
I
V
K
K
F
G
N
----
F
---
T
---
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
---
Y
F
D
E
K
D
V
-
T
-----
E
L
P
P
K
D
R
N
-
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
-----------
Y
K
N
I
A
F
P
L
E
L
R
K
A
---
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
-
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
-
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
--
D
R
I
A
V
I
R
E
G
E
I
L
Q
-----------
4
PsiBlast_PDB
75.83
38%
-6
- C1 -
-
3TUJ
-
METN_ECOLI
C:
[2-227]
-
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
125
HHSearch
74.19
31%
-128
- C1 -
-
3RLF
2
MALK_ECOLI
A:
[3-221]
S
V
Q
L
Q
N
V
T
K
A
W
G
E
----
V
---
V
---
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
---
F
I
G
E
K
R
M
-
N
D
T
-----
P
P
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-----------
A
E
N
M
S
F
G
L
K
L
A
G
A
---
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
-
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
--
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----
26
PsiBlast_CBE
73.95
38%
-8
- C1 -
-
3TUI
1
METN_ECOLI
D:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
126
HHSearch
73.75
39%
-7
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-229]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
TRT
I
---
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
---
21
PsiBlast_CBE
73.53
38%
-15
- C1 -
-
3TUZ
1
METN_ECOLI
H:
[24-250]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
41
PsiBlast_CBE
71.25
37%
37
- C1 -
-
1L2T
3
Y796_METJA
B:
[1-232]
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
---
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
D
L
----
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
-----------
L
E
N
V
E
L
P
L
I
F
K
Y
R
GAM
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
V
V
V
T
H
D
---
I
N
V
A
R
FG
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--
E
K
L
R
G
F
--
1
PsiBlast_PDB
70.83
38%
-3
- C1 -
-
3DHW
-
METN_ECOLI
C:
[1-227]
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
RTI
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
E
L
-
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
-----------
F
G
N
V
A
L
P
L
E
L
D
N
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
--
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
-----
42
PsiBlast_CBE
70.50
36%
39
- C1 -
-
3TIF
4
Y796_METJA
B:
[1-232]
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
---
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
D
L
----
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
-----------
L
E
N
V
E
L
P
L
I
F
K
Y
R
GAM
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
-
E
D
G
K
T
V
V
V
V
T
H
D
---
I
N
V
A
R
FG
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
--
E
K
L
R
G
F
--
101
PsiBlast_CBE
52.90
37%
-29
- C1 -
-
1XEF
2
D:
[21-216]
----------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
----
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
DNISLANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
-----
A
H
D
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
----
D
R
I
I
V
M
E
K
G
K
I
V
------------
103
PsiBlast_CBE
52.48
37%
-31
- C1 -
-
1XEF
2
HLYBP_ECOLX
B:
[21-216]
----------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
----
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
DNISLANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
-----
A
H
D
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
----
D
R
I
I
V
M
E
K
G
K
I
V
------------
99
PsiBlast_CBE
52.34
37%
-29
- C1 -
-
2FGJ
2
HLYBP_ECOLX
A:
[27-222]
----------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
----
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
ANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
-----
A
H
D
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
----
D
R
I
I
V
M
E
K
G
K
I
V
------------
102
PsiBlast_CBE
52.26
37%
-33
- C1 -
-
1XEF
2
HLYBP_ECOLX
C:
[21-216]
----------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
----
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
DNISLANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
-----
A
H
D
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
----
D
R
I
I
V
M
E
K
G
K
I
V
------------
98
PsiBlast_CBE
51.92
37%
-32
- C1 -
-
2FGJ
2
HLYBP_ECOLX
B:
[27-222]
----------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
---
L
I
D
G
H
D
L
A
L
A
D
P
N
----
W
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
DNISLANPGMS
V
E
K
V
I
Y
A
A
K
L
A
G
-----
A
H
D
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
-
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
-
G
-
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
----
D
R
I
I
V
M
E
K
G
K
I
V
------------