@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XWV3: (2017-12-31 )
MNYRVAVLGPGSWGTALAQVLAENGHDVRIWGHRASQVEEINTQHTNQRYLPDHCLPDSIQAFTNMEDAVKDADAVLFVIPTKAIRSVAKELVPKLNTKPVIIHASKGLEQGTHKRISDILLEEIPVEKRKAVVVLSGPSHAEEVAKHDITTITAASTDAKAAKYVQELFMNNYFRIYTNPDVIGVEMGAALKNIIAIGAGAIHGLGFGDNAKAAIMTRGLAEISRLGVAMGANPLTFIGLSGVGDLVVTCTSVHSRNWRAGNLLGQGQPLEEVLANMGMVVEGVNTTQAAMELAQIMEIEMPITQTIYEVLYEQKEIKTAAKEIMLRDGKKENEFSLTIF
Atome Classification :
(20 SA)
-----.........10........20...-------..--------.--------..30-------......-----..40........50........60........70........80........90----......-----..-----100-........110..--.....120.......130.--......140.......150.......160--------..---------......170-..--......180.......190.......200.......210.......220..---.....230--..--......-240.......250.......260.....----.-.-.270---.......--.280.......290.-......300---.-........310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----M
N
Y
R
V
A
V
LGPG
S
W
G
T
A
L
A
Q
V
L
A
EN-------G
H
--------
D
--------
V
R
I
W-------GHRA
S
Q
-----
V
E
E
I
NTQHTNQRYLPDHCL
P
D
S
I
Q
A
F
T
N
M
E
D
A
VKDA
D
A
V
L
F
V
I
P
T
K
A
I
R
S
V
A
K
E
----
L
V
P
KLN-----TK-----
P
-
V
-
I
I
H
ASKGLEQ
G
T
H
--
K
R
I
S
D
I
L
L
E
EIPVEK
R
K
A
V
--
V
V
LSGP
S
H
A
E
E
V
A
KHD
I
T
T
I
TAAST
D
A
K
---------
A
A
---------
K
Y
V
Q
E
L
F
M--NN--
Y
F
R
I
YTNP
D
V
I
G
V
E
M
G
A
A
L
K
N
I
I
A
IGAG
A
I
HGLGFGDN
A
K
A
A
I
M
T
R
G
L
A
E
I
---
S
R
L
G
VAM---GA--N
P
L
T
F
I
-GLSGVG
D
L
V
V
T
C
TSVHSRNWR-AGNLLG----Q-G-Q
P
L
----
E
E
V
L
A
NM--G
M
V
V
EGV
N
T
T
Q
A
A
M
E
-
L
A
Q
I
M
E
I-----E-M
P
I
T
Q
T
I
Y
E
V
L
Y
E
Q
K
E
I
K
T
A
A
K
E
I
M
LRDGKKEN
E
F
S
L
T
IF
55
HHSearch
79.49
37%
-87
- C1 -
-
3K96
2
GPDA_COXBU
B:
[28-351]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
--------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
I
D
-----
A
K
-----
T
-
R
-
I
A
W
G
T
K
G
L
A
K
G
S
---
R
L
L
H
E
V
V
A
T
E
L
G
---
Q
V
P
M
--
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
---------
F
S
---------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
-
L
G
----
E
-
G
-
V
D
K
----
K
E
A
Q
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
-
L
A
Q
K
H
A
I
-----
E
-
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
-------------
54
HHSearch
79.40
37%
-83
- C1 -
-
3K96
1
GPDA_COXBU
A:
[28-352]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
--------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
I
D
-----
A
K
-----
T
-
R
-
I
A
W
G
T
K
G
L
A
K
G
S
---
R
L
L
H
E
V
V
A
T
E
L
G
---
Q
V
P
M
--
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
---------
F
S
---------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
-
L
G
----
E
-
G
-
V
D
K
----
K
E
A
Q
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
-
L
A
Q
K
H
A
I
-----
E
-
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
------------
56
HHSearch
79.01
33%
-
- C1 -
-
4FGW
-
GPD1_YEAST
B:
[33-385]
-----
K
P
F
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
-------
C
K
GYPEVFAP
I
--------
V
Q
M
W
-------
V
F
E
E
E
I
NGEKL
T
E
I
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
----
L
K
G
H
V
D
-----
S
H
-----
V
-
R
-
A
I
S
C
L
K
G
F
E
V
G
A
K
GV
Q
L
L
S
S
Y
I
T
E
E
L
G
----
I
Q
C
--
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
I
P
K
DFRGEGKDV
D
H
---------
K
V
L
K
A
L
F
H
--
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
---
I
R
F
G
Q
M
F
---
F
P
ES
R
E
E
T
Y
Y
Q
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
R
L
M
A
T---
S
-
G
-
K
D
A
WECE
K
E
L
L
N
----
G
Q
S
A
Q
G
L
I
T
C
K
E
V
H
E
-
W
L
E
T
C
G
S
VE---
D
-
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
L
P
D
M
I
E
E
--------------
53
HHSearch
76.09
43%
-97
- C1 -
-
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
-------
G
E
--------
E
--------
V
I
L
W
-------
A
R
R
K
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
--
K
I
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
----
L
P
V
--------
K
P
-----
S
-
M
-
V
L
N
L
S
K
G
I
E
I
K
T
G
--
K
R
V
S
E
I
V
E
E
I
L
G
----
C
P
Y
--
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
---------------------
K
E
L
Q
K
R
I
S
--
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
---
G
A
--
D
Q
K
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
E
L
I
A
----
R
-
G
-
F
N
P
L
---
K
L
L
-
E
S
S
--
N
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
-
I
A
K
E
N
K
I
-----
D
-
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
--------------
49
HHSearch
74.82
35%
-46
- C1 -
-
1N1E
1
GPDA_LEIME
B:
[15-352]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
G
G
N
L
I
AYAKE
K
Q
-----
V
-
P
-
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
---
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
--
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
T
S
--
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
------
50
HHSearch
74.39
35%
-48
- C1 -
-
1EVY
1
GPDA_LEIME
A:
[15-352]
------
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
G
G
N
L
I
A
Y
A
K
E
K
Q
-----
V
-
P
-
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
S
---
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
--
T
G
DR
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
------
9
PsiBlast_PDB
74.03
35%
-48
- C1 -
-
1N1G
3
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
14
PsiBlast_PDB
73.75
30%
-
- C1 -
-
4FGW
-
GPD1_YEAST
A:
[35-377]
-------
F
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
E
N
-------
C
K
--------
G
Y
P
EVFAP
I
V
Q
M
W
V
F
E
E
E
I
N
G
E
K
L
T
E
-----
I
--
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
R
I
C
S
Q
----
L
K
G
H
V
D
-----
S
H
-----
V
-
R
-
A
I
S
C
L
K
G
F
E
V
G
A
K
G
V
Q
L
L
S
S
Y
I
T
E
E
L
G
I
Q
----
C
--
G
A
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
I
P
K
---------
D
F
R
G
E
GKDVD
H
K
V
L
K
A
L
F
H
--
R
P
--
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
---
I
R
F
G
Q
M
F
FPE
S
R
--
E
E
T
Y
Y
Q
-
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
-
V
A
R
L
M
A
T
SGK
D
-
A
-
W
E
C
----
E
K
E
L
L
N
---
G
Q
S
A
Q
G
L
I
T
C
K
E
V
H
E
W
L
E
T
C
G
S
V
-----
E
D
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
----------------------
1
PsiBlast_PDB
73.46
37%
-33
- C1 -
-
3K96
1
GPDA_COXBU
A:
[28-352]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
--------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
I
D
-----
A
K
-----
T
-
R
-
I
A
W
G
T
K
G
L
A
K
G
S
R
--------
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
---------
F
S
---------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
L
A
L
G
----
E
-
G
-
V
D
K
----
K
E
A
Q
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
-
L
A
Q
K
H
A
I
-----
E
-
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
------------
3
PsiBlast_PDB
73.45
35%
-50
- C1 -
-
1EVY
1
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
22
PsiBlast_CBE
73.44
35%
-48
- C1 -
-
1N1E
1
GPDA_LEIME
B:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SGGN
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
T
S
--
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
21
PsiBlast_CBE
73.42
37%
-36
- C1 -
-
3K96
2
GPDA_COXBU
B:
[28-351]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
R
K
-------
G
Q
--------
K
--------
V
R
L
W
-------
S
Y
E
S
D
H
-----
V
D
E
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
----
M
K
P
L
I
D
-----
A
K
-----
T
-
R
-
I
A
W
G
T
K
G
L
A
K
G
S
R
--------
L
L
H
E
V
V
A
T
E
L
G
Q
V
PM
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
---------
F
S
---------
K
D
L
I
E
R
L
H
--
G
Q
--
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
--
K
Q
E
T
L
T
-
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
-
F
G
L
A
L
G
----
E
-
G
-
V
D
K
----
K
E
A
Q
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
-
L
A
Q
K
H
A
I
-----
E
-
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
-------------
8
PsiBlast_PDB
72.92
35%
-48
- C1 -
-
1N1E
1
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
T
S
--
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
6
PsiBlast_PDB
72.89
35%
-48
- C1 -
-
1M66
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
7
PsiBlast_PDB
72.79
35%
-53
- C1 -
-
1M67
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
5
PsiBlast_PDB
72.41
35%
-48
- C1 -
-
1JDJ
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
4
PsiBlast_PDB
72.37
35%
-48
- C1 -
-
1EVZ
2
GPDA_LEIME
A:
[17-343]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
SG
G
N
L
I
A
Y
A
K
-----
E
K
-----
Q
-
V
P
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
---------------
2
PsiBlast_PDB
71.11
42%
-34
- C1 -
-
1Z82
7
?
A:
[16-325]
--------
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
E
N
-------
G
E
--------
E
--------
V
I
L
W
-------
A
R
R
K
E
I
-----
V
D
L
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
K
I
--
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
----
E
----
H
L
L
R
L
P
-----
V
K
-----
P
S
M
-
V
L
N
L
S
K
G
I
E
I
K
T
G
--
K
R
V
S
E
I
V
E
E
I
L
G
C
----
P
Y
--
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
K
---------
E
------------
L
Q
K
R
I
S
--
T
E
--
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
---
G
A
--
D
Q
K
T
F
M
-
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
-
F
G
E
L
I
A
----
R
-
G
F
N
P
L
-----
K
L
L
E
S
S
--
N
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
-
I
A
K
E
N
K
I
-----
D
-
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
--------------
41
Fugue
68.71
34%
20
* C1 *
-
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
K
K
-------
C
R
--------
E
--------
V
C
V
W
-------
H
M
N
E
E
E
-----
V
R
L
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
----
S
G
G
N
L
I
-----
A
Y
A
K
E
K
Q
V
-
P
-
V
L
V
C
T
K
G
I
E
R
S
T
L
--
K
F
P
A
E
I
I
G
E
F
L
P
---
S
P
L
L
--
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
---------
V
A
---------
R
R
L
Q
R
I
M
S
TG
D
R
--
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
--
D
G
S
A
V
F
-
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
-
V
G
K
K
L
G
----
K
-
G
-
L
P
I
----
E
E
I
Q
-----
R
A
V
A
E
G
V
A
T
A
D
P
L
M
R
-
L
A
K
Q
L
K
V
-----
K
-
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
L
F
K
-
23
PsiBlast_CBE
65.81
31%
-16
- C1 -
-
2PLA
1
GPD1L_HUMAN
B:
[7-338]
--------
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
N
N
VKKLQKF
A
S
--------
T
--------
V
K
M
W
VFEETVN
G
R
K
L
T
D
-----
I
--
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
R
I
C
D
E
----
I
T
G
R
V
P
-----
K
K
-----
A
-
L
-
G
I
T
L
I
K
G
I
D
E
G
P
E
GL
K
L
I
S
D
I
I
R
E
K
M
G
I
D
----
I
--
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
S
K
V
M
E
---------
N
G
---------
L
L
F
K
E
L
L
Q
--
T
P
--
N
F
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
IAF
A
R
I
F
C
K
G
---
Q
V
--
S
T
A
T
F
L
-
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
-
V
A
E
A
F
A
----
R
T
G
-
K
T
I
----
E
E
L
E
K
E
M
LN
G
Q
K
L
Q
G
---
P
Q
T
S
A
E
-
V
Y
R
I
L
K
Q
KGLLD
K
-
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
V
Q
----------------------