@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXR7: (2018-01-05 )
MELNRMIDHTILKADASKEAVMQIIEEAKKYHFYSVCINPAWVALAKEQLQGEPVAVCTVIGFPLGANTPETKAFETTDAINNGADEVDMVINIGALKSKDDQQVQKDIEAVVEAAKDRALVKVIIETSLLDREEIIRACEIAKAAGADFVKTSTGFSTGGAKVEDVRLMRETVGPEMGVKASGGIHNEEEAMAMIEAGATRIGTSAGVAIVSGSTGEGY
Atome Classification :
(43 SA)
.........10........20........30--........40........50-.---...---.....60........70........80........90........100.......--110.....-..120........130---..---.-....-.140.......150.....-..-160.......170..---..---.--..180-----........190.......------------200.......210.......220
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
L
N
R
M
I
D
H
T
I
LKADA
S
K
E
A
V
M
Q
I
I
E
E
A
K
K
Y
--
H
F
Y
S
V
CI
N
P
A
W
V
A
L
A
K
E
Q
L--Q---GE
P
---
V
A
V
C
T
V
IGFPLGANTPETKAFETTDAINNGAD
E
V
D
M
V
I
N
IGALKSK
D
D
Q
Q
V
Q
K
D
I
--
E
A
V
V
E
A
AK-D
R
A
-
L
V
K
V
I
I
E
T
SLL----
D
R
---
E
-
E
I
I
R
-
A
C
E
I
A
K
AAGA
D
F
V
K
TSTGF-ST-GGA
K
V
E
D
V
R
L
M
R
E
TV---GP---E--MGVK------ASGGIH
N
E
E
E
A
M
A
M
I
E
AG------------ATRIGTSA
G
V
A
I
V
SGSTGEGY
72
HHSearch
94.00
64%
-97
* C4 *
-
5DBU
-
?
B:
[4-213]
M
K
L
N
K
Y
I
D
H
T
I
L
K
P
E
T
T
Q
E
Q
V
E
K
I
L
A
E
A
K
E
Y
--
D
F
A
S
V
C
V
N
P
T
W
V
A
L
A
A
E
S
L
--
K
---
D
S
D
---
V
K
V
C
T
V
I
G
F
P
L
G
A
N
T
P
A
V
K
A
F
E
T
K
D
A
I
S
N
G
A
D
E
I
D
M
V
I
N
I
G
A
L
K
T
G
N
Y
D
L
V
L
E
D
I
--
K
A
V
V
A
A
S
G
-
D
-
K
-
L
V
K
V
I
I
E
A
C
L
L
----
T
D
---
D
-
E
K
V
K
-
A
C
Q
L
S
Q
E
A
G
A
D
Y
V
K
T
S
T
G
F
-
S
T
-
G
G
A
T
V
A
D
V
A
L
M
R
K
T
V
---
G
P
---
D
--
M
G
V
K
------
A
S
G
G
A
R
S
Y
E
D
A
I
A
F
I
E
A
G
------------
A
S
R
I
G
A
S
S
G
V
A
I
---------
1
PsiBlast_PDB
93.04
63%
-92
- C4 -
-
5DBU
-
?
A:
[4-214]
M
K
L
N
K
Y
I
D
H
T
I
L
K
P
E
T
T
Q
E
Q
V
E
K
I
L
A
E
A
K
E
Y
--
D
F
A
S
V
C
V
N
P
T
W
V
A
L
A
A
E
S
L
--
K
---
D
S
D
---
V
K
V
C
T
V
I
G
F
P
L
G
A
N
T
P
A
V
K
A
F
E
T
K
D
A
I
S
N
G
A
D
E
I
D
M
V
I
N
I
G
A
L
K
T
G
N
Y
D
L
V
L
E
D
I
--
K
A
V
V
A
A
S
G
-
D
K
--
L
V
K
V
I
I
E
A
C
L
L
----
T
D
---
D
-
E
K
V
K
-
A
C
Q
L
S
Q
E
A
G
A
D
Y
V
K
T
S
T
G
F
-
S
T
-
G
G
A
T
V
A
D
V
A
L
M
R
K
T
V
---
G
P
---
D
--
M
G
V
K
------
A
S
G
G
A
R
S
Y
E
D
A
I
A
F
I
E
A
G
------------
A
S
R
I
G
A
S
S
G
V
A
I
M
--------
25
PsiBlast_CBE
92.30
55%
-114
- C4 -
-
3NGJ
1
?
B:
[27-237]
--
L
A
K
Y
I
D
H
T
L
L
K
A
D
A
T
E
E
Q
I
R
K
L
C
S
E
A
A
E
Y
--
K
F
A
S
V
C
V
N
P
T
W
V
P
L
C
A
E
L
L
--
K
---
G
T
G
---
V
K
V
C
T
V
I
G
F
P
L
G
A
T
P
S
E
V
K
A
Y
E
T
K
V
A
V
E
Q
G
A
E
E
V
D
M
V
I
N
I
G
M
V
K
A
K
K
Y
D
D
V
E
K
D
V
--
K
A
V
V
D
A
S
--
G
K
A
-
L
T
K
V
I
I
E
C
C
Y
L
----
T
N
---
E
-
E
K
V
E
-
V
C
K
R
C
V
A
A
G
A
E
Y
V
K
T
S
T
G
F
-
G
T
-
H
G
A
T
P
E
D
V
K
L
M
K
D
T
V
---
G
D
---
K
--
A
L
V
K
------
A
A
G
G
I
R
T
F
D
D
A
M
K
M
I
N
N
G
------------
A
S
R
I
G
A
S
A
G
I
A
I
L
N
G
------
6
PsiBlast_PDB
92.18
55%
-111
- C4 -
-
3NGJ
-
?
A:
[27-237]
--
L
A
K
Y
I
D
H
T
L
L
K
A
D
A
T
E
E
Q
I
R
K
L
C
S
E
A
A
E
Y
--
K
F
A
S
V
C
V
N
P
T
W
V
P
L
C
A
E
L
L
--
K
---
G
T
G
---
V
K
V
C
T
V
I
G
F
P
L
G
A
T
P
S
E
V
K
A
Y
E
T
K
V
A
V
E
Q
G
A
E
E
V
D
M
V
I
N
I
G
M
V
K
A
K
K
Y
D
D
V
E
K
D
V
--
K
A
V
V
D
A
S
--
G
K
A
-
L
T
K
V
I
I
E
C
C
Y
L
----
T
N
---
E
-
E
K
V
E
-
V
C
K
R
C
V
A
A
G
A
E
Y
V
K
T
S
T
G
F
-
G
T
-
H
G
A
T
P
E
D
V
K
L
M
K
D
T
V
---
G
D
---
K
--
A
L
V
K
------
A
A
G
G
I
R
T
F
D
D
A
M
K
M
I
N
N
G
------------
A
S
R
I
G
A
S
A
G
I
A
I
L
N
G
------
77
HHSearch
91.99
55%
-113
- C4 -
-
3NGJ
1
?
D:
[26-238]
-
T
L
A
K
Y
I
D
H
T
L
L
K
A
D
A
T
E
E
Q
I
R
K
L
C
S
E
A
A
E
Y
--
K
F
A
S
V
C
V
N
P
T
W
V
P
L
C
A
E
L
L
--
K
---
G
T
G
---
V
K
V
C
T
V
I
G
F
P
L
G
A
T
P
S
E
V
K
A
Y
E
T
K
V
A
V
E
Q
G
A
E
E
V
D
M
V
I
N
I
G
M
V
K
A
K
K
Y
D
D
V
E
K
D
V
--
K
A
V
V
D
A
S
G
-
K
-
A
-
L
T
K
V
I
I
E
C
C
Y
L
----
T
N
---
E
-
E
K
V
E
-
V
C
K
R
C
V
A
A
G
A
E
Y
V
K
T
S
T
G
F
-
G
T
-
H
G
A
T
P
E
D
V
K
L
M
K
D
T
V
---
G
D
---
K
--
A
L
V
K
------
A
A
G
G
I
R
T
F
D
D
A
M
K
M
I
N
N
G
------------
A
S
R
I
G
A
S
A
G
I
A
I
L
N
G
I
-----
23
PsiBlast_CBE
91.86
55%
-113
- C4 -
-
3NGJ
1
?
D:
[27-237]
--
L
A
K
Y
I
D
H
T
L
L
K
A
D
A
T
E
E
Q
I
R
K
L
C
S
E
A
A
E
Y
--
K
F
A
S
V
C
V
N
P
T
W
V
P
L
C
A
E
L
L
--
K
---
G
T
G
---
V
K
V
C
T
V
I
G
F
P
L
G
A
T
P
S
E
V
K
A
Y
E
T
K
V
A
V
E
Q
G
A
E
E
V
D
M
V
I
N
I
G
M
V
K
A
K
K
Y
D
D
V
E
K
D
V
--
K
A
V
V
D
A
S
--
G
K
A
-
L
T
K
V
I
I
E
C
C
Y
L
----
T
N
---
E
-
E
K
V
E
-
V
C
K
R
C
V
A
A
G
A
E
Y
V
K
T
S
T
G
F
-
G
T
-
H
G
A
T
P
E
D
V
K
L
M
K
D
T
V
---
G
D
---
K
--
A
L
V
K
------
A
A
G
G
I
R
T
F
D
D
A
M
K
M
I
N
N
G
------------
A
S
R
I
G
A
S
A
G
I
A
I
L
N
G
------
24
PsiBlast_CBE
91.45
55%
-111
- C4 -
-
3NGJ
2
?
C:
[27-237]
--
L
A
K
Y
I
D
H
T
L
L
K
A
D
A
T
E
E
Q
I
R
K
L
C
S
E
A
A
E
Y
--
K
F
A
S
V
C
V
N
P
T
W
V
P
L
C
A
E
L
L
--
K
---
G
T
G
---
V
K
V
C
T
V
I
G
F
P
L
G
A
T
P
S
E
V
K
A
Y
E
T
K
V
A
V
E
Q
G
A
E
E
V
D
M
V
I
N
I
G
M
V
K
A
K
K
Y
D
D
V
E
K
D
V
--
K
A
V
V
D
A
S
--
G
K
A
-
L
T
K
V
I
I
E
C
C
Y
L
----
T
N
---
E
-
E
K
V
E
-
V
C
K
R
C
V
A
A
G
A
E
Y
V
K
T
S
T
G
F
-
G
T
-
H
G
A
T
P
E
D
V
K
L
M
K
D
T
V
---
G
D
---
K
--
A
L
V
K
------
A
A
G
G
I
R
T
F
D
D
A
M
K
M
I
N
N
G
------------
A
S
R
I
G
A
S
A
G
I
A
I
L
N
G
------
71
HHSearch
90.65
55%
-100
- C4 -
-
3R13
2
DEOC_THEMA
B:
[42-257]
-
D
V
K
S
A
I
E
H
T
N
L
K
P
F
A
T
P
D
D
I
K
K
L
C
L
E
A
R
E
N
--
R
F
H
G
V
C
V
N
P
C
Y
V
K
L
A
R
E
E
L
--
E
---
G
T
D
---
V
K
V
V
T
V
V
G
F
P
L
G
A
N
E
T
R
T
K
A
H
E
A
I
F
A
V
E
S
G
A
D
E
I
D
M
V
I
N
V
G
M
L
K
A
K
E
W
E
Y
V
Y
E
D
I
--
R
S
V
V
E
S
V
K
-
G
-
K
-
V
V
K
V
I
I
E
T
C
Y
L
----
D
T
---
E
-
E
K
I
A
-
A
C
V
I
S
K
L
A
G
A
H
F
V
K
T
S
T
G
F
-
G
T
-
G
G
A
T
A
E
D
V
H
L
M
K
W
I
V
---
G
D
---
E
--
M
G
V
K
------
A
S
G
G
I
R
T
F
E
D
A
V
K
M
I
M
Y
G
------------
A
D
R
I
G
T
S
S
G
V
K
I
V
Q
G
G
E
E
R
--
70
HHSearch
88.60
55%
-100
- C4 -
-
3R12
3
DEOC_THEMA
A:
[42-257]
-
D
V
K
S
A
I
E
H
T
N
L
K
P
F
A
T
P
D
D
I
K
K
L
C
L
E
A
R
E
N
--
R
F
H
G
V
C
V
N
P
C
Y
V
K
L
A
R
E
E
L
--
E
---
G
T
D
---
V
K
V
V
T
V
V
G
F
P
L
G
A
N
E
T
R
T
K
A
H
E
A
I
F
A
V
E
S
G
A
D
E
I
D
M
V
I
N
V
G
M
L
K
A
K
E
W
E
Y
V
Y
E
D
I
--
R
S
V
V
E
S
V
K
-
G
-
K
-
V
V
K
V
I
I
E
T
C
Y
L
----
D
T
---
E
-
E
K
I
A
-
A
C
V
I
S
K
L
A
G
A
H
F
V
K
T
S
T
G
F
-
G
T
-
G
G
A
T
A
E
D
V
H
L
M
K
W
I
V
---
G
D
---
E
--
M
G
V
K
------
A
S
G
G
I
R
T
F
E
D
A
V
K
M
I
M
Y
G
------------
A
D
R
I
G
T
S
S
G
V
K
I
V
Q
G
G
E
E
R
--
7
PsiBlast_PDB
88.20
53%
-102
- C4 -
-
3R12
3
DEOC_THEMA
A:
[42-253]
-
D
V
K
S
A
I
E
H
T
N
L
K
P
F
A
T
P
D
D
I
K
K
L
C
L
E
A
R
E
N
--
R
F
H
G
V
C
V
N
P
C
Y
V
K
L
A
R
E
E
L
--
E
---
G
T
D
---
V
K
V
V
T
V
V
G
F
P
L
G
A
N
E
T
R
T
K
A
H
E
A
I
F
A
V
E
S
G
A
D
E
I
D
M
V
I
N
V
G
M
L
K
A
K
E
W
E
Y
V
Y
E
D
I
--
R
S
V
V
E
S
V
K
-
G
K
--
V
V
K
V
I
I
E
T
C
Y
L
----
D
T
---
E
-
E
K
I
A
-
A
C
V
I
S
K
L
A
G
A
H
F
V
K
T
S
T
G
F
-
G
T
-
G
G
A
T
A
E
D
V
H
L
M
K
W
I
V
---
G
D
---
E
--
M
G
V
K
------
A
S
G
G
I
R
T
F
E
D
A
V
K
M
I
M
Y
G
------------
A
D
R
I
G
T
S
S
G
V
K
I
V
Q
G
------
2
PsiBlast_PDB
88.01
64%
-96
- C4 -
-
5DBT
-
?
A:
[4-204]
M
K
L
N
K
Y
I
D
H
T
I
L
K
P
E
T
T
Q
E
Q
V
E
K
I
L
A
E
A
K
E
Y
--
D
F
A
S
V
C
V
N
P
T
W
V
A
L
A
A
E
S
L
--
K
---
D
S
D
---
V
K
V
C
T
V
I
G
F
P
L
G
A
N
T
P
A
V
K
A
F
E
T
K
D
A
I
S
N
G
A
D
E
I
D
M
V
I
N
I
G
A
L
K
T
G
N
Y
D
L
V
L
E
D
I
--
K
A
V
V
A
A
S
G
-
D
K
--
L
V
K
V
I
I
E
A
C
L
L
----
T
D
---
D
-
E
K
V
K
-
A
C
Q
L
S
Q
E
A
G
A
D
Y
V
K
T
S
T
G
F
-
S
T
-
G
G
A
T
V
A
D
V
A
L
M
R
K
T
V
---
G
P
---
D
--
M
G
V
K
------
A
S
G
G
A
R
S
Y
E
D
A
I
A
F
I
E
A
G
------------
A
S
R
------------------
8
PsiBlast_PDB
87.08
53%
-101
- C4 -
-
3R13
2
DEOC_THEMA
A:
[42-253]
-
D
V
K
S
A
I
E
H
T
N
L
K
P
F
A
T
P
D
D
I
K
K
L
C
L
E
A
R
E
N
--
R
F
H
G
V
C
V
N
P
C
Y
V
K
L
A
R
E
E
L
--
E
---
G
T
D
---
V
K
V
V
T
V
V
G
F
P
L
G
A
N
E
T
R
T
K
A
H
E
A
I
F
A
V
E
S
G
A
D
E
I
D
M
V
I
N
V
G
M
L
K
A
K
E
W
E
Y
V
Y
E
D
I
--
R
S
V
V
E
S
V
K
-
G
K
--
V
V
K
V
I
I
E
T
C
Y
L
----
D
T
---
E
-
E
K
I
A
-
A
C
V
I
S
K
L
A
G
A
H
F
V
K
T
S
T
G
F
-
G
T
-
G
G
A
T
A
E
D
V
H
L
M
K
W
I
V
---
G
D
---
E
--
M
G
V
K
------
A
S
G
G
I
R
T
F
E
D
A
V
K
M
I
M
Y
G
------------
A
D
R
I
G
T
S
S
G
V
K
I
V
Q
G
------
5
PsiBlast_PDB
86.55
54%
-49
- C4 -
-
5H91
-
?
A:
[43-255]
-
Q
L
A
K
Y
I
D
H
T
N
L
K
A
D
A
T
E
A
D
I
K
Q
L
C
D
E
A
K
K
F
--
N
T
A
S
V
C
V
N
S
Y
W
I
P
F
V
T
E
Q
L
--
K
---
G
T
D
---
V
N
P
I
A
V
V
G
F
P
L
G
A
M
A
T
E
S
E
I
F
E
A
T
T
A
I
D
Q
G
A
E
E
I
D
M
V
L
N
V
G
E
L
K
G
G
N
D
E
K
V
L
A
D
I
--
Q
G
L
A
D
A
V
H
-
A
K
G
K
I
L
K
V
I
L
E
N
A
L
L
----
T
K
---
D
-
E
I
V
R
-
A
C
Q
L
S
E
K
A
G
A
D
F
V
K
T
S
T
G
Y
-
S
T
-
S
G
A
K
V
E
D
V
K
L
M
R
E
T
V
---
G
D
---
R
--
L
G
V
K
------
A
S
G
G
I
H
S
R
E
E
A
L
A
M
I
D
A
G
------------
A
S
R
M
G
V
S
A
T
V
A
I
L
T
-------
4
PsiBlast_PDB
86.22
55%
-48
- C4 -
-
4XBK
-
?
A:
[43-255]
-
Q
L
A
K
Y
I
D
H
T
N
L
K
A
D
A
T
E
A
D
I
K
Q
T
C
D
E
A
K
K
F
--
N
T
A
S
V
C
V
N
S
Y
W
I
P
F
V
T
E
Q
L
--
K
---
G
T
D
---
V
N
P
I
A
V
V
G
F
P
L
G
A
M
A
T
E
S
E
I
F
E
A
T
T
A
I
D
Q
G
A
E
E
I
D
M
V
L
N
V
G
E
L
K
G
G
N
D
E
K
V
L
A
D
I
--
Q
G
L
A
D
A
V
H
-
A
K
G
K
I
L
K
V
I
L
E
N
A
L
L
----
T
K
---
D
-
E
I
V
R
-
A
C
Q
L
S
E
K
A
G
A
D
F
V
K
T
S
T
G
F
-
S
T
-
S
G
A
K
V
E
D
V
K
L
M
R
E
T
V
---
G
D
---
R
--
L
G
V
K
------
A
S
G
G
I
H
S
R
E
E
A
L
A
M
I
D
A
G
------------
A
S
R
M
G
V
S
A
T
V
A
I
L
T
-------
22
PsiBlast_CBE
85.93
54%
-52
- C4 -
-
5H91
2
?
B:
[43-255]
-
Q
L
A
K
Y
I
D
H
T
N
L
K
A
D
A
T
E
A
D
I
K
Q
L
C
D
E
A
K
K
F
--
N
T
A
S
V
C
V
N
S
Y
W
I
P
F
V
T
E
Q
L
--
K
---
G
T
D
---
V
N
P
I
A
V
V
G
F
P
L
G
A
M
A
T
E
S
E
I
F
E
A
T
T
A
I
D
Q
G
A
E
E
I
D
M
V
L
N
V
G
E
L
K
G
G
N
D
E
K
V
L
A
D
I
--
Q
G
L
A
D
A
V
H
-
A
K
G
K
I
L
K
V
I
L
E
N
A
L
L
----
T
K
---
D
-
E
I
V
R
-
A
C
Q
L
S
E
K
A
G
A
D
F
V
K
T
S
T
G
Y
-
S
T
-
S
G
A
K
V
E
D
V
K
L
M
R
E
T
V
---
G
D
---
R
--
L
G
V
K
------
A
S
G
G
I
H
S
R
E
E
A
L
A
M
I
D
A
G
------------
A
S
R
M
G
V
S
A
T
V
A
I
L
T
-------
21
PsiBlast_CBE
85.27
55%
-53
- C4 -
-
4XBK
3
?
B:
[43-255]
-
Q
L
A
K
Y
I
D
H
T
N
L
K
A
D
A
T
E
A
D
I
K
Q
T
C
D
E
A
K
K
F
--
N
T
A
S
V
C
V
N
S
Y
W
I
P
F
V
T
E
Q
L
--
K
---
G
T
D
---
V
N
P
I
A
V
V
G
F
P
L
G
A
M
A
T
E
S
E
I
F
E
A
T
T
A
I
D
Q
G
A
E
E
I
D
M
V
L
N
V
G
E
L
K
G
G
N
D
E
K
V
L
A
D
I
--
Q
G
L
A
D
A
V
H
-
A
K
G
K
I
L
K
V
I
L
E
N
A
L
L
----
T
K
---
D
-
E
I
V
R
-
A
C
Q
L
S
E
K
A
G
A
D
F
V
K
T
S
T
G
F
-
S
T
-
S
G
A
K
V
E
D
V
K
L
M
R
E
T
V
---
G
D
---
R
--
L
G
V
K
------
A
S
G
G
I
H
S
R
E
E
A
L
A
M
I
D
A
G
------------
A
S
R
M
G
V
S
A
T
V
A
I
L
T
-------
3
PsiBlast_PDB
84.53
55%
-53
- C- -
-
4XBS
-
?
A:
[7-219]
-
Q
L
A
K
Y
I
D
H
T
N
L
K
A
D
A
T
E
A
D
I
K
Q
T
C
D
E
A
K
K
F
--
N
T
A
S
V
C
V
N
S
Y
W
I
P
F
V
T
E
Q
L
--
K
---
G
T
D
---
V
N
P
I
A
V
V
G
F
P
L
G
A
M
A
T
E
S
K
I
F
E
A
T
T
A
I
D
Q
G
A
E
E
I
D
M
V
L
N
V
G
E
L
K
G
G
N
D
E
K
V
L
A
D
I
--
Q
G
L
A
D
A
V
H
-
A
K
G
K
I
L
K
V
I
L
E
N
A
L
L
----
T
K
---
D
-
E
I
V
R
-
A
C
Q
L
S
E
K
A
G
A
D
F
V
K
T
S
T
G
F
-
S
T
-
S
G
A
K
V
E
D
V
K
L
M
R
E
T
V
---
G
D
---
R
--
L
G
V
K
------
A
S
G
G
I
H
S
R
E
E
A
L
A
M
I
D
A
G
------------
A
S
R
M
G
V
S
A
T
V
A
I
L
T
-------
65
HHSearch
84.01
46%
-82
- C4 -
-
3OA3
-
?
A:
[57-274]
-
S
I
A
Q
I
I
D
H
T
Q
L
S
L
S
A
T
G
S
Q
I
D
V
L
C
A
E
A
K
E
Y
--
G
F
A
T
V
C
V
R
P
D
Y
V
S
R
A
V
Q
Y
L
--
Q
---
G
T
Q
---
V
G
V
T
C
V
I
G
F
H
E
G
T
Y
S
T
D
Q
K
V
S
E
A
K
R
A
M
Q
N
G
A
S
E
L
D
M
V
M
N
Y
P
W
L
S
E
K
R
Y
T
D
V
F
Q
D
I
--
R
A
V
R
L
A
A
K
-
D
-
A
-
I
L
K
V
I
L
E
T
S
Q
L
----
T
A
---
D
-
E
I
I
A
-
G
C
V
L
S
S
L
A
G
A
D
Y
V
K
T
S
T
G
F
-
N
G
-
P
G
A
S
I
E
N
V
S
L
M
S
A
V
C
---
D
S
LQS
E
--
T
R
V
K
------
A
S
G
G
I
R
T
I
E
D
C
V
K
M
V
R
A
G
------------
A
E
R
L
G
A
S
A
G
V
K
I
V
N
E
T
R
L
---
66
HHSearch
83.50
46%
-80
- C4 -
-
3OA3
-
?
B:
[57-273]
-
S
I
A
Q
I
I
D
H
T
Q
L
S
L
S
A
T
G
S
Q
I
D
V
L
C
A
E
A
K
E
Y
--
G
F
A
T
V
C
V
R
P
D
Y
V
S
R
A
V
Q
Y
L
--
Q
---
G
T
Q
---
V
G
V
T
C
V
I
G
F
H
E
G
T
Y
S
T
D
Q
K
V
S
E
A
K
R
A
M
Q
N
G
A
S
E
L
D
M
V
M
N
Y
P
W
L
S
E
K
R
Y
T
D
V
F
Q
D
I
--
R
A
V
R
L
A
A
K
-
D
-
A
-
I
L
K
V
I
L
E
T
S
Q
L
----
T
A
---
D
-
E
I
I
A
-
G
C
V
L
S
S
L
A
G
A
D
Y
V
K
T
S
T
G
F
-
N
G
-
P
G
A
S
I
E
N
V
S
L
M
S
A
V
C
---
D
S
LQS
E
--
T
R
V
K
------
A
S
G
G
I
R
T
I
E
D
C
V
K
M
V
R
A
G
------------
A
E
R
L
G
A
S
A
G
V
K
I
V
N
E
T
R
----
12
PsiBlast_PDB
81.82
41%
-108
- C4 -
-
1MZH
-
DEOC_AQUAE
A:
[2-209]
I
D
V
R
K
Y
I
D
N
A
A
L
K
P
H
L
S
E
K
E
I
E
E
F
V
L
K
S
E
E
L
--
G
I
Y
A
V
C
V
N
P
Y
H
V
K
L
A
S
S
I
-------
A
K
K
---
V
K
V
C
C
V
I
G
F
P
L
G
L
N
K
T
S
V
K
V
K
E
A
V
E
A
V
R
D
G
A
Q
E
L
D
I
V
W
N
L
S
A
F
K
S
E
K
Y
D
F
V
V
E
E
L
--
K
E
I
F
R
E
T
P
-
S
-
A
-
V
H
K
V
I
V
E
T
P
Y
L
----
N
E
---
E
-
E
I
K
K
-
A
V
E
I
C
I
E
A
G
A
D
F
I
K
T
S
T
G
F
-
A
P
-
R
G
T
T
L
E
E
V
R
L
I
K
S
S
A
---
K
G
---
R
--
I
K
V
K
------
A
S
G
G
I
R
D
L
E
T
A
I
S
M
I
E
A
G
------------
A
D
R
I
G
T
S
S
G
I
S
I
---------
26
PsiBlast_CBE
81.22
46%
-104
- C4 -
-
1UB3
1
DEOC_THET8
D:
[2-212]
-
D
L
A
A
H
I
D
H
T
L
L
K
P
T
A
T
L
E
E
V
A
K
A
A
E
E
A
L
E
Y
--
G
F
Y
G
L
C
I
P
P
S
Y
V
A
W
V
R
A
R
Y
--
P
---
H
A
P
---
F
R
L
V
T
V
V
G
F
P
L
G
Y
Q
E
K
E
V
K
A
L
E
A
A
L
A
C
A
R
G
A
D
E
V
D
M
V
L
H
L
G
R
A
K
A
G
D
L
D
Y
L
E
A
E
V
--
R
A
V
R
E
A
V
P
--
Q
A
-
V
L
K
V
I
L
E
T
G
Y
F
----
S
P
---
E
-
E
I
A
R
-
L
A
E
A
A
I
R
G
G
A
D
F
L
K
T
S
T
G
F
-
G
P
-
R
G
A
S
L
E
D
V
A
L
L
V
R
V
A
---
Q
G
---
R
--
A
Q
V
K
------
A
A
G
G
I
R
D
R
E
T
A
L
R
M
L
K
A
G
------------
A
S
R
L
G
T
S
S
G
V
A
L
V
A
-------
28
PsiBlast_CBE
80.56
46%
-105
- C4 -
-
1UB3
1
DEOC_THET8
B:
[1-211]
M
D
L
A
A
H
I
D
H
T
L
L
K
P
T
A
T
L
E
E
V
A
K
A
A
E
E
A
L
E
Y
--
G
F
Y
G
L
C
I
P
P
S
Y
V
A
W
V
R
A
R
Y
--
P
---
H
A
P
---
F
R
L
V
T
V
V
G
F
P
L
G
Y
Q
E
K
E
V
K
A
L
E
A
A
L
A
C
A
R
G
A
D
E
V
D
M
V
L
H
L
G
R
A
K
A
G
D
L
D
Y
L
E
A
E
V
--
R
A
V
R
E
A
V
P
--
Q
A
-
V
L
K
V
I
L
E
T
G
Y
F
----
S
P
---
E
-
E
I
A
R
-
L
A
E
A
A
I
R
G
G
A
D
F
L
K
T
S
T
G
F
-
G
P
-
R
G
A
S
L
E
D
V
A
L
L
V
R
V
A
---
Q
G
---
R
--
A
Q
V
K
------
A
A
G
G
I
R
D
R
E
T
A
L
R
M
L
K
A
G
------------
A
S
R
L
G
T
S
S
G
V
A
L
V
--------
76
HHSearch
80.44
43%
-68
- C4 -
-
3NDO
3
?
A:
[11-230]
A
Q
V
A
A
L
V
D
H
T
L
L
K
P
E
A
T
P
S
D
V
T
A
L
V
D
E
A
A
D
L
--
G
V
F
A
V
C
V
S
P
P
L
V
S
V
A
A
G
V
A
------
P
S
G
---
L
A
I
A
A
V
A
G
F
P
S
G
K
H
V
P
G
I
K
A
T
E
A
E
L
A
V
A
A
G
A
T
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
A
V
S
A
D
I
--
T
A
V
R
K
A
V
R
-
A
-
A
-
T
L
K
V
I
V
E
S
A
A
L
----
L
E
F
SG
E
P
L
L
A
D
-
V
C
R
V
A
R
D
A
G
A
D
F
V
K
T
S
T
G
F
-
H
P
S
G
G
A
S
V
Q
A
V
E
I
M
A
R
T
V
---
G
E
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
E
Q
A
A
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
S
R
A
V
L
D
G
F
G
S
---
10
PsiBlast_PDB
79.89
46%
-99
- C4 -
-
1UB3
1
DEOC_THET8
A:
[2-212]
-
D
L
A
A
H
I
D
H
T
L
L
K
P
T
A
T
L
E
E
V
A
K
A
A
E
E
A
L
E
Y
--
G
F
Y
G
L
C
I
P
P
S
Y
V
A
W
V
R
A
R
Y
--
P
---
H
A
P
---
F
R
L
V
T
V
V
G
F
P
L
G
Y
Q
E
K
E
V
K
A
L
E
A
A
L
A
C
A
R
G
A
D
E
V
D
M
V
L
H
L
G
R
A
K
A
G
D
L
D
Y
L
E
A
E
V
--
R
A
V
R
E
A
V
P
--
Q
A
-
V
L
K
V
I
L
E
T
G
Y
F
----
S
P
---
E
-
E
I
A
R
-
L
A
E
A
A
I
R
G
G
A
D
F
L
K
T
S
T
G
F
-
G
P
-
R
G
A
S
L
E
D
V
A
L
L
V
R
V
A
---
Q
G
---
R
--
A
Q
V
K
------
A
A
G
G
I
R
D
R
E
T
A
L
R
M
L
K
A
G
------------
A
S
R
L
G
T
S
S
G
V
A
L
V
A
-------
31
PsiBlast_CBE
78.87
42%
-69
- C4 -
-
3NDO
3
?
B:
[12-227]
-
Q
V
A
A
L
V
D
H
T
L
L
K
P
E
A
T
P
S
D
V
T
A
L
V
D
E
A
A
D
L
--
G
V
F
A
V
C
V
S
P
P
L
V
S
V
A
A
-
G
V
--
A
---
P
S
G
---
L
A
I
A
A
V
A
G
F
P
S
G
K
H
V
P
G
I
K
A
T
E
A
E
L
A
V
A
A
G
A
T
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
A
V
S
A
D
I
--
T
A
V
R
K
A
V
R
--
A
A
-
T
L
K
V
I
V
E
S
A
A
L
LEF-
S
G
---
E
-
P
L
L
A
D
V
C
R
V
A
R
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
Q
A
V
E
I
M
A
R
T
V
---
G
E
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
E
Q
A
A
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
S
R
A
V
L
D
G
------
27
PsiBlast_CBE
78.82
46%
-102
- C4 -
-
1UB3
1
DEOC_THET8
C:
[2-211]
-
D
L
A
A
H
I
D
H
T
L
L
K
P
T
A
T
L
E
E
V
A
K
A
A
E
E
A
L
E
Y
--
G
F
Y
G
L
C
I
P
P
S
Y
V
A
W
V
R
A
R
Y
--
P
---
H
A
P
---
F
R
L
V
T
V
V
G
F
P
L
G
Y
Q
E
K
E
V
K
A
L
E
A
A
L
A
C
A
R
G
A
D
E
V
D
M
V
L
H
L
G
R
A
K
A
G
D
L
D
Y
L
E
A
E
V
--
R
A
V
R
E
A
V
P
--
Q
A
-
V
L
K
V
I
L
E
T
G
Y
F
----
S
P
---
E
-
E
I
A
R
-
L
A
E
A
A
I
R
G
G
A
D
F
L
K
T
S
T
G
F
-
G
P
-
R
G
A
S
L
E
D
V
A
L
L
V
R
V
A
---
Q
G
---
R
--
A
Q
V
K
------
A
A
G
G
I
R
D
R
E
T
A
L
R
M
L
K
A
G
------------
A
S
R
L
G
T
S
S
G
V
A
L
V
--------
13
PsiBlast_PDB
78.65
42%
-68
- C4 -
-
3NDO
3
?
A:
[12-227]
-
Q
V
A
A
L
V
D
H
T
L
L
K
P
E
A
T
P
S
D
V
T
A
L
V
D
E
A
A
D
L
--
G
V
F
A
V
C
V
S
P
P
L
V
S
V
A
A
-
G
V
--
A
---
P
S
G
---
L
A
I
A
A
V
A
G
F
P
S
G
K
H
V
P
G
I
K
A
T
E
A
E
L
A
V
A
A
G
A
T
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
A
V
S
A
D
I
--
T
A
V
R
K
A
V
R
--
A
A
-
T
L
K
V
I
V
E
S
A
A
L
L
E
F
-
S
G
---
E
-
P
L
L
A
D
V
C
R
V
A
R
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
Q
A
V
E
I
M
A
R
T
V
---
G
E
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
E
Q
A
A
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
S
R
A
V
L
D
G
------
33
PsiBlast_CBE
75.55
44%
-62
- C4 -
-
3NG3
4
DEOC_MYCA1
C:
[11-225]
-
Q
L
A
A
F
V
D
H
T
L
L
K
P
E
A
T
A
A
D
V
A
A
L
V
T
E
A
A
E
L
--
G
V
Y
A
V
C
V
S
P
P
M
V
P
A
A
V
Q
A
-------
G
A
G
---
V
R
V
A
S
V
A
G
F
P
S
G
K
H
V
S
A
V
K
A
H
E
A
A
L
A
V
A
S
G
A
A
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
G
V
R
A
D
I
--
A
A
V
-
R
G
A
V
-
G
G
A
-
V
L
K
V
I
V
E
S
S
A
L
L
A
L
A
D
E
---
H
-
T
L
V
R
-
V
C
R
A
A
E
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
R
A
V
A
L
M
A
E
A
V
---
G
G
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
A
D
A
L
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
T
R
A
V
L
D
G
------
32
PsiBlast_CBE
75.00
44%
-60
- C4 -
-
3NG3
2
DEOC_MYCA1
D:
[11-225]
-
Q
L
A
A
F
V
D
H
T
L
L
K
P
E
A
T
A
A
D
V
A
A
L
V
T
E
A
A
E
L
--
G
V
Y
A
V
C
V
S
P
P
M
V
P
A
A
V
Q
A
-------
G
-----
V
R
V
A
S
V
A
G
F
P
S
G
K
H
V
S
A
V
K
A
H
E
A
A
L
A
V
A
S
G
A
A
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
G
V
R
A
D
I
--
A
A
V
-
R
G
A
V
-
G
G
A
-
V
L
K
V
I
V
E
S
S
A
L
LALA
D
E
---
H
-
T
L
V
R
-
V
C
R
A
A
E
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
R
A
V
A
L
M
A
E
A
V
---
G
G
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
A
D
A
L
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
T
R
A
V
L
D
G
------
14
PsiBlast_PDB
74.17
44%
-54
- C4 -
-
3NG3
1
DEOC_MYCA1
A:
[11-225]
-
Q
L
A
A
F
V
D
H
T
L
L
K
P
E
A
T
A
A
D
V
A
A
L
V
T
E
A
A
E
L
--
G
V
Y
A
V
C
V
S
P
P
M
V
P
A
A
V
Q
A
-------
G
A
-----
R
V
A
S
V
A
G
F
P
S
G
K
H
V
S
A
V
K
A
H
E
A
A
L
A
V
A
S
G
A
A
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
G
V
R
A
D
I
--
A
A
V
-
R
G
A
V
-
G
G
A
-
V
L
K
V
I
V
E
S
S
A
L
L
A
L
A
D
E
---
H
-
T
L
V
R
-
V
C
R
A
A
E
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
R
A
V
A
L
M
A
E
A
V
---
G
G
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
A
D
A
L
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
T
R
A
V
L
D
G
------
34
PsiBlast_CBE
73.06
44%
-57
- C4 -
-
3NG3
2
DEOC_MYCA1
B:
[11-225]
-
Q
L
A
A
F
V
D
H
T
L
L
K
P
E
A
T
A
A
D
V
A
A
L
V
T
E
A
A
E
L
--
G
V
Y
A
V
C
V
S
P
P
M
V
P
A
A
V
Q
A
--------------
R
V
A
S
V
A
G
F
P
S
G
K
H
V
S
A
V
K
A
H
E
A
A
L
A
V
A
S
G
A
A
E
I
D
M
V
I
D
V
G
A
A
L
A
G
D
L
D
G
V
R
A
D
I
--
A
A
V
-
R
G
A
V
-
G
G
A
-
V
L
K
V
I
V
E
S
S
A
L
L
A
L
A
D
E
---
H
-
T
L
V
R
-
V
C
R
A
A
E
D
A
G
A
D
F
V
K
T
S
T
G
F
H
P
S
-
G
G
A
S
V
R
A
V
A
L
M
A
E
A
V
---
G
G
---
R
--
L
G
V
K
------
A
S
G
G
I
R
T
A
A
D
A
L
A
M
L
D
A
G
------------
A
T
R
L
G
L
S
G
T
R
A
V
L
D
G
------
16
PsiBlast_PDB
64.15
37%
-2
- C4 -
-
5EKY
2
DEOC_ECOLI
A:
[13-216]
----
K
L
M
D
L
T
T
L
N
D
D
D
T
D
E
K
V
I
A
L
C
H
Q
A
K
T
P
VG
N
T
A
A
I
C
I
Y
P
R
F
I
P
I
A
R
E
T
L
K
E
Q
---
G
T
P
E--
I
R
I
A
T
V
T
N
F
P
H
G
N
D
D
I
D
I
A
L
A
E
T
R
A
A
I
A
W
G
A
D
E
V
D
V
V
F
P
Y
R
A
L
M
A
G
N
-
E
Q
V
G
F
D
L
V
K
A
C
K
E
A
C
A
A
-
A
N
V
-
L
L
K
V
I
I
E
T
G
E
L
----
K
D
---
E
-
A
L
I
R
K
A
S
E
I
S
I
K
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
V
N
A
T
P
E
S
A
R
I
M
M
E
V
I
R
D
M
G
V
---
E
KT
V
G
F
K
------
P
A
G
G
V
R
T
A
E
D
A
Q
K
Y
L
------------------------------------
17
PsiBlast_PDB
63.98
37%
-3
- C4 -
-
5EL1
2
DEOC_ECOLI
A:
[13-216]
----
K
L
M
D
L
T
T
L
N
D
D
D
T
D
E
K
V
I
A
L
C
H
Q
A
K
T
P
VG
N
T
A
A
I
C
I
Y
P
R
F
I
P
I
A
R
E
T
L
K
E
Q
---
G
T
P
E--
I
R
I
A
T
V
T
N
F
P
H
G
N
D
D
I
D
I
A
L
A
E
T
R
A
A
I
A
W
G
A
D
E
V
D
V
V
F
P
Y
R
A
L
M
A
G
N
-
E
Q
V
G
F
D
L
V
K
A
C
K
E
A
C
A
A
-
A
N
V
-
L
L
K
V
I
I
E
T
G
E
L
----
K
D
---
E
-
A
L
I
R
K
A
S
E
I
S
I
K
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
V
N
A
T
P
E
S
A
R
I
M
M
E
V
I
R
D
M
G
V
---
E
KT
V
G
F
K
------
P
A
G
G
V
R
T
A
E
D
A
Q
K
Y
L
------------------------------------
18
PsiBlast_PDB
63.12
37%
-2
- C4 -
-
5EMU
2
DEOC_ECOLI
A:
[13-216]
----
K
L
M
D
L
T
T
L
N
D
D
D
T
D
E
K
V
I
A
L
C
H
Q
A
K
T
P
VG
N
T
A
A
I
C
I
Y
P
R
F
I
P
I
A
R
E
T
L
K
E
Q
---
G
T
P
E--
I
R
I
A
T
V
T
N
F
P
H
G
N
D
D
I
D
I
A
L
A
E
T
R
A
A
I
A
W
G
A
D
E
V
D
V
V
F
P
Y
R
A
L
M
A
G
N
-
E
Q
V
G
F
D
L
V
K
A
C
K
E
A
C
A
A
-
A
N
V
-
L
L
K
V
I
I
E
T
G
E
L
----
K
D
---
E
-
A
L
I
R
K
A
S
E
I
S
I
K
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
V
N
A
T
P
E
S
A
R
I
M
M
E
V
I
R
D
M
G
V
---
E
KT
V
G
F
K
------
P
A
G
G
V
R
T
A
E
D
A
Q
K
Y
L
------------------------------------
37
PsiBlast_CBE
61.64
35%
-2
- C4 -
-
1JCJ
1
DEOC_ECOLI
A:
[14-217]
----
K
L
M
D
L
T
T
L
N
D
D
D
T
D
E
K
V
I
A
L
C
H
Q
A
K
T
P
VG
N
T
A
A
I
C
I
Y
P
R
F
I
P
I
A
R
K
T
L
K
E
Q
---
G
T
P
E--
I
R
I
A
T
V
T
N
F
P
H
G
N
D
D
I
D
I
A
L
A
E
T
R
A
A
I
A
Y
G
A
D
E
V
D
V
V
F
P
Y
R
A
L
M
A
G
N
-
E
Q
V
G
F
D
L
V
K
A
C
K
E
A
C
A
A
-
A
N
V
-
L
L
K
V
I
I
E
T
G
E
L
----
K
D
---
E
-
A
L
I
R
K
A
S
E
I
S
I
K
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
V
N
A
T
P
E
S
A
R
I
M
M
E
V
I
----
R
---
D
--
M
G
V
E
KT
V
G
F
L
P
A
G
G
V
R
T
A
E
D
A
Q
K
Y
L
------------------------------------
40
PsiBlast_CBE
60.74
31%
20
- C4 -
-
5C5Y
2
?
B:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
K
N
K
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
42
PsiBlast_CBE
60.35
31%
18
- C4 -
-
5C2X
1
?
B:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
KNK
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
39
PsiBlast_CBE
59.48
31%
18
- C4 -
-
5C5Y
1
?
C:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
KNK
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
38
PsiBlast_CBE
59.29
31%
19
- C4 -
-
5C5Y
3
?
D:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
KNK
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
41
PsiBlast_CBE
59.18
31%
19
- C4 -
-
5C5Y
3
?
A:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
K
N
K
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
61
HHSearch
59.13
32%
1
- C4 -
-
5C5Y
3
?
D:
[10-243]
-
R
A
L
S
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
AQQ
T
P
H
---
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
-
I
G
F
D
M
--
V
K
V
C
K
Q
A
C
S
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
E
L
I
R
K
-
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
KNK
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
DNILGNEWADAN
H
F
R
F
G
A
S
S
L
L
I
S
L
L
D
------
43
PsiBlast_CBE
59.09
31%
19
- C4 -
-
5C2X
1
?
A:
[14-221]
-----
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
---
A
Q
Q
TPH
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
I
G
F
D
M
V
--
K
V
C
K
Q
A
C
S
-
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
-
E
L
I
R
K
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
K
N
K
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
------------
D
N
I
L
G
----------------
62
HHSearch
58.45
32%
1
- C4 -
-
5C5Y
1
?
C:
[10-243]
-
R
A
L
S
L
M
D
L
T
S
L
T
N
T
E
T
D
Q
E
I
I
D
L
C
R
Q
A
K
S
P
AG
E
T
A
A
I
C
I
F
P
R
F
I
P
V
A
K
K
A
L
--
K
AQQ
T
P
H
---
I
K
I
A
T
V
T
N
F
P
Q
G
N
D
D
L
D
I
A
L
A
E
T
R
A
A
V
A
Y
G
A
D
E
V
D
L
V
F
P
Y
R
A
L
I
Q
G
N
E
T
-
I
G
F
D
M
--
V
K
V
C
K
Q
A
C
S
G
N
A
-
K
L
K
V
I
I
E
T
G
E
L
----
K
S
---
E
E
L
I
R
K
-
A
S
E
I
A
I
N
A
G
A
D
F
I
K
T
S
T
G
K
-
V
A
-
I
N
A
T
P
E
A
A
K
V
M
L
T
V
I
KNK
N
T
---
A
--
V
G
F
K
------
P
A
G
G
V
R
N
A
D
D
A
A
I
Y
L
D
L
A
DNILGNEWADAN
H
F
R
F
G
A
S
S
L
L
I
S
L
L
D
------