@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZK9: (2018-01-15 )
MMEFSMDMFRLDGKVALVTGAVYGIGFEIARSLATAGAKIVFNNLNQESVDEGIAHYKEAGIDAKGYVCDVTDEEAVQAMVQQIKEDVGSVDILVNNAGIIKRTPMIEMDAADFRQVIDVDLNAPFIVSKAVIPDMIEKGGGKIINICSMMSELGRETVSAYAAAKGGLKMLTKNIASEYGQYNIQCNGIGPGYIATPQTAPLRETQENGERHPFDQFIVGRTPAARWGEPIDLAGPSVFLASSASDFVNGHVLYVDGGILAYIGKQP
Atome Classification :
(22 SA)
.........-10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......-140........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMEF
S
M
D
M
F
-RLDG
K
V
A
L
V
T
G
A
V
Y
G
I
G
F
E
I
A
R
S
L
A
TAG
A
K
I
V
F
NNL
N
Q
E
S
V
D
E
G
I
A
H
Y
K
E
AGIDAK
G
Y
V
C
DVT
D
E
E
A
V
Q
A
M
V
Q
Q
I
K
E
D
VGS
V
D
I
L
VNNAGIIKRT
P
M
I
EM
D
A
A
D
F
R
Q
V
I
DVDLNA
P
F
I
V
S
K
A
V
I
P
D
M
I
E
K-G-G
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
AAKG
G
L
K
M
L
T
K
N
I
A
S
EYG
Q
Y
N
I
Q
CNGIGPGYIATPQTAPLRETQENGERHP
F
D
Q
FIVGRT
P
A
ARWGEPIDLAGP
S
V
F
L
ASS
A
S
D
FVNG
H
V
L
Y
VDG
G
I
L
A
YIGKQP
3
PsiBlast_PDB
91.18
77%
-105
- C- -
-
4Z9X
-
?
A:
[3-264]
------
N
M
F
-
S
L
Q
G
K
I
A
L
I
T
G
A
S
Y
G
I
G
F
E
I
A
K
A
Y
A
Q
A
G
A
T
I
V
F
N
D
I
K
Q
E
L
V
D
K
G
L
A
A
Y
R
E
L
G
I
E
A
H
G
Y
V
C
D
V
T
D
E
A
G
I
Q
Q
M
V
S
Q
I
E
D
E
V
G
A
I
D
I
L
V
N
N
A
G
I
I
R
R
T
P
M
L
E
M
A
A
E
D
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
L
P
S
M
I
A
K
-
G
-
H
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
F
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
R
-----
R
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
T
T
E
D
L
A
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
2
PsiBlast_PDB
90.69
79%
-116
- C1 -
-
3O03
2
?
A:
[24-289]
--
Q
F
S
L
D
Q
F
-
S
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
L
V
D
R
G
M
A
A
Y
K
A
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
M
I
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
-
G
-
H
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
------------
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
1
PsiBlast_PDB
90.07
79%
-111
- C1 -
-
3CXR
-
?
A:
[4-269]
--
Q
F
S
L
D
Q
F
-
S
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
L
V
D
R
G
M
A
A
Y
K
A
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
M
I
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
-
G
-
H
G
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
L
------
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
Q
P
4
PsiBlast_PDB
88.53
75%
-119
- C1 -
-
4U8G
-
?
A:
[4-267]
--
Q
F
L
K
D
N
F
-
S
L
E
G
K
V
A
L
I
T
G
A
S
Y
G
I
G
F
S
I
A
T
A
F
A
R
A
G
A
T
I
V
F
N
D
I
K
Q
E
L
V
D
K
G
I
S
A
Y
K
K
L
G
I
K
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
N
E
M
V
D
K
I
S
Q
D
V
G
V
I
D
I
L
V
N
N
A
G
I
I
K
R
T
P
M
L
E
M
S
A
A
D
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
L
P
G
M
I
Q
K
-
G
-
H
G
K
I
I
N
I
C
A
M
M
S
E
L
G
R
E
T
V
A
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
S
A
N
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
R
Q
D
D
G
S
R
H
P
F
D
Q
F
I
I
A
K
T
P
A
A
R
W
G
E
A
E
D
L
G
A
P
A
I
F
L
A
S
D
A
S
N
F
I
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
I
G
K
--
27
PsiBlast_CBE
76.41
43%
-100
- C1 -
-
5U9P
5
?
D:
[9-265]
-
M
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
-
G
-
H
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
R
A
L
V
D
D
A
------
A
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
----
29
PsiBlast_CBE
75.25
43%
-96
- C1 -
-
5U9P
7
?
B:
[9-265]
-
M
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
-
G
-
H
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
R
A
L
V
D
D
A
------
A
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
----
7
PsiBlast_PDB
75.19
43%
-99
- C1 -
-
5U9P
7
?
A:
[9-265]
-
M
T
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
-
G
-
H
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
R
A
L
V
D
D
A
------
A
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
----
28
PsiBlast_CBE
74.17
43%
-98
- C1 -
-
5U9P
7
?
C:
[11-265]
---
H
A
L
D
R
F
-
R
L
D
G
R
R
A
L
I
T
G
S
G
R
G
I
G
L
T
L
A
R
G
L
A
E
A
G
A
A
I
V
I
N
D
R
N
E
E
K
A
A
T
L
A
R
R
F
R
D
E
G
F
A
A
D
H
A
V
F
D
V
A
E
H
A
Q
V
R
A
A
I
D
E
F
E
A
R
V
G
A
I
D
I
L
V
N
N
A
G
I
Q
R
R
A
P
L
D
A
F
E
P
D
D
W
H
A
L
M
R
V
N
L
D
G
V
F
N
V
A
Q
A
V
A
R
H
M
I
A
R
-
G
-
H
G
K
I
I
N
I
C
S
V
Q
S
E
L
A
R
P
T
I
A
P
Y
A
A
T
K
G
A
V
R
M
L
T
K
G
M
C
A
D
W
A
R
Y
G
I
Q
A
N
G
L
A
P
G
Y
F
E
T
E
L
N
R
A
L
V
D
D
A
------
A
F
S
D
W
L
C
K
R
T
P
A
G
R
W
G
Q
V
D
E
L
C
G
A
A
I
F
L
A
S
A
A
S
D
F
V
N
G
Q
T
L
F
V
D
G
G
L
T
S
A
V
----
6
PsiBlast_PDB
73.31
45%
-96
- C1 -
-
4IBO
-
?
A:
[21-271]
-------
I
F
-
D
L
G
G
R
T
A
L
V
T
G
S
S
R
G
L
G
R
A
M
A
E
G
L
A
V
A
G
A
R
I
L
I
N
G
T
D
P
S
R
V
A
Q
T
V
Q
E
F
R
N
V
G
H
D
A
E
A
V
A
F
D
V
T
S
E
S
E
I
I
E
A
F
A
R
L
D
E
Q
G
I
D
V
D
I
L
V
N
N
A
G
I
Q
F
R
K
P
M
I
E
L
E
T
A
D
W
Q
R
V
I
D
T
N
L
T
S
A
F
M
I
G
R
E
A
A
K
R
M
I
P
R
-
G
-
Y
G
K
I
V
N
I
G
S
L
T
S
E
L
A
R
A
T
V
A
P
Y
T
V
A
K
G
G
I
K
M
L
T
R
A
M
A
A
E
W
A
Q
Y
G
I
Q
A
N
A
I
G
P
G
Y
M
L
T
D
M
N
Q
A
L
I
D
N
P
E
------
F
D
A
W
V
K
A
R
T
P
A
K
R
W
G
K
P
Q
E
L
V
G
T
A
V
F
L
S
A
S
A
S
D
Y
V
N
G
Q
I
I
Y
V
D
G
G
M
L
S
V
L
----
151
HHSearch
73.06
46%
-92
- C1 -
-
4IBO
-
?
D:
[18-269]
----
N
Q
I
I
F
-
D
L
G
G
R
T
A
L
V
T
G
S
S
R
G
L
G
R
A
M
A
E
G
L
A
V
A
G
A
R
I
L
I
N
G
T
D
P
S
R
V
A
Q
T
V
Q
E
F
R
N
V
G
H
D
A
E
A
V
A
F
D
V
T
S
E
S
E
I
I
E
A
F
A
R
L
D
E
Q
G
I
D
V
D
I
L
V
N
N
A
G
I
Q
F
R
K
P
M
I
E
L
E
T
A
D
W
Q
R
V
I
D
T
N
L
T
S
A
F
M
I
G
R
E
A
A
K
R
M
I
P
R
-
G
-
Y
G
K
I
V
N
I
G
S
L
T
S
E
L
A
R
A
T
V
A
P
Y
T
V
A
K
G
G
I
K
M
L
T
R
A
M
A
A
E
W
A
Q
Y
G
I
Q
A
N
A
I
G
P
G
Y
M
L
T
D
M
N
Q
A
L
I
D
N
P
------
E
F
D
A
W
V
K
A
R
T
P
A
K
R
W
G
K
P
Q
E
L
V
G
T
A
V
F
L
S
A
S
A
S
D
Y
V
N
G
Q
I
I
Y
V
D
G
G
M
L
S
------
22
PsiBlast_CBE
72.39
44%
-63
- C1 -
-
4G81
1
?
B:
[4-255]
-------
L
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
----
5
PsiBlast_PDB
72.30
44%
-65
- C1 -
-
4G81
1
?
D:
[4-255]
-------
L
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
----
23
PsiBlast_CBE
70.64
44%
-66
- C1 -
-
4G81
1
?
A:
[4-255]
-------
L
F
-
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
K
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
N
S
-
G
G
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
K
Q
------
F
D
S
W
V
K
S
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
V
L
----
152
HHSearch
70.29
46%
-92
* C1 *
-
4IBO
-
?
B:
[19-269]
-----
Q
I
I
F
-
D
L
G
G
R
T
A
L
V
T
G
S
S
R
G
L
G
R
A
M
A
E
G
L
A
V
A
G
A
R
I
L
I
N
G
T
D
P
S
R
V
A
Q
T
V
Q
E
F
R
N
V
G
H
D
A
E
A
V
A
F
D
V
T
S
E
S
E
I
I
E
A
F
A
R
L
D
E
Q
G
I
D
V
D
I
L
V
N
N
A
G
I
Q
F
R
K
P
M
I
E
L
E
T
A
D
W
Q
R
V
I
D
T
N
L
T
S
A
F
M
I
G
R
E
A
A
K
R
M
I
P
R
-
G
-
Y
G
K
I
V
N
I
G
S
L
T
S
E
L
A
R
A
T
V
A
P
Y
T
V
A
K
G
G
I
K
M
L
T
R
A
M
A
A
E
W
A
Q
Y
G
I
Q
A
N
A
I
G
P
G
Y
M
L
T
D
M
N
Q
A
L
I
D
N
P
------
E
F
D
A
W
V
K
A
R
T
P
A
K
R
W
G
K
P
Q
E
L
V
G
T
A
V
F
L
S
A
S
A
S
D
Y
V
N
G
Q
I
I
Y
V
D
G
G
M
L
S
------
37
PsiBlast_CBE
67.79
39%
-104
- C1 -
-
3UF0
1
?
B:
[27-272]
--------
F
-
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
D
G
V
K
E
V
A
D
E
I
A
D
G
G
G
S
A
E
A
V
V
A
D
L
A
D
L
E
G
A
A
N
V
A
E
E
L
A
A
-
T
R
R
V
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
-
G
-
S
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
A
A
E
------
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
------
11
PsiBlast_PDB
67.63
39%
-104
- C1 -
-
3UF0
1
?
A:
[27-272]
--------
F
-
S
L
A
G
R
T
A
V
V
T
G
A
G
S
G
I
G
R
A
I
A
H
G
Y
A
R
A
G
A
H
V
L
A
W
G
-
R
T
D
G
V
K
E
V
A
D
E
I
A
D
G
G
G
S
A
E
A
V
V
A
D
L
A
D
L
E
G
A
A
N
V
A
E
E
L
A
A
-
T
R
R
V
D
V
L
V
N
N
A
G
I
I
A
R
A
P
A
E
E
V
S
L
G
R
W
R
E
V
L
T
V
N
L
D
A
A
W
V
L
S
R
S
F
G
T
A
M
L
A
H
-
G
-
S
G
R
I
V
T
I
A
S
M
L
S
F
Q
G
G
R
N
V
A
A
Y
A
A
S
K
H
A
V
V
G
L
T
R
A
L
A
S
E
W
A
G
R
G
V
G
V
N
A
L
A
P
G
Y
V
V
T
A
N
T
A
A
L
R
A
D
D
E
R
A
A
E
------
I
T
A
R
I
P
A
G
R
W
A
T
P
E
D
M
V
G
P
A
V
F
L
A
S
D
A
A
S
Y
V
H
G
Q
V
L
A
V
D
G
G
W
L
A
------
145
HHSearch
67.60
41%
-70
- C1 -
-
4Z9Y
-
?
C:
[4-252]
------
N
S
F
-
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
I
V
E
P
K
--
D
T
I
E
K
V
T
A
L
G
R
R
F
L
S
L
T
A
D
M
S
N
V
S
G
H
A
E
L
V
E
K
A
V
A
E
F
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
G
K
-
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
------
E
R
S
K
E
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
------
9
PsiBlast_PDB
67.58
40%
-73
- C1 -
-
4ZA2
-
?
A:
[3-252]
-----
L
N
S
F
-
D
L
Q
G
K
V
A
L
I
T
G
C
D
T
G
L
G
Q
G
M
A
I
G
L
A
Q
A
G
C
D
I
V
G
V
N
I
V
E
P
K
--
D
T
I
E
K
V
T
A
L
G
R
R
F
L
S
L
T
A
D
M
S
N
V
S
G
H
A
E
L
V
E
K
A
V
A
E
F
G
H
V
D
I
L
V
N
N
A
G
I
I
R
R
E
D
A
I
E
F
S
E
K
N
W
D
D
V
M
N
L
N
I
K
S
V
F
F
M
S
Q
T
V
A
R
Q
F
I
K
Q
-
G
K
G
G
K
I
I
N
I
A
S
M
L
S
F
Q
G
G
I
R
V
P
S
Y
T
A
S
K
S
A
V
M
G
V
T
R
L
M
A
N
E
W
A
K
H
G
I
N
V
N
A
I
A
P
G
Y
M
A
T
N
N
T
Q
Q
L
R
A
D
E
E
R
S
K
E
------
I
L
D
R
I
P
A
G
R
W
G
L
P
Q
D
L
M
G
P
S
V
F
L
A
S
S
A
S
D
Y
I
N
G
Y
T
I
A
V
D
G
G
W
L
A
------
72
PsiBlast_CBE
67.46
36%
-111
- C1 -
-
1AHH
1
HDHA_ECOLI
B:
[2-249]
---
F
N
S
D
N
L
-
R
L
D
G
K
C
A
I
I
T
G
A
G
A
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
V
V
S
D
I
N
A
D
A
A
N
H
V
V
D
E
I
Q
Q
L
G
G
Q
A
F
A
C
R
C
D
I
T
S
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
P
K
P
F
-
D
M
P
M
A
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
S
Q
L
V
A
P
E
M
E
K
N
-
G
-
G
G
V
I
L
T
I
T
S
M
A
A
E
N
K
N
I
N
M
T
S
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
D
L
G
E
K
N
I
R
V
N
G
I
A
P
G
A
I
L
T
D
A
L
K
S
V
I
T
P
E
-------
I
E
Q
K
M
L
Q
H
T
P
I
R
R
L
G
Q
P
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
---------
73
PsiBlast_CBE
67.24
36%
-112
- C1 -
-
1AHH
1
HDHA_ECOLI
A:
[2-249]
---
F
N
S
D
N
L
-
R
L
D
G
K
C
A
I
I
T
G
A
G
A
G
I
G
K
E
I
A
I
T
F
A
T
A
G
A
S
V
V
V
S
D
I
N
A
D
A
A
N
H
V
V
D
E
I
Q
Q
L
G
G
Q
A
F
A
C
R
C
D
I
T
S
E
Q
E
L
S
A
L
A
D
F
A
I
S
K
L
G
K
V
D
I
L
V
N
N
A
G
G
G
G
P
K
P
F
-
D
M
P
M
A
D
F
R
R
A
Y
E
L
N
V
F
S
F
F
H
L
S
Q
L
V
A
P
E
M
E
K
N
-
G
-
G
G
V
I
L
T
I
T
S
M
A
A
E
N
K
N
I
N
M
T
S
Y
A
S
S
K
A
A
A
S
H
L
V
R
N
M
A
F
D
L
G
E
K
N
I
R
V
N
G
I
A
P
G
A
I
L
T
D
A
L
K
S
V
I
T
P
E
-------
I
E
Q
K
M
L
Q
H
T
P
I
R
R
L
G
Q
P
Q
D
I
A
N
A
A
L
F
L
C
S
P
A
A
S
W
V
S
G
Q
I
L
T
V
S
G
G
---------
47
PsiBlast_CBE
51.79
36%
-3
- C1 -
-
3RRO
5
FABG_VIBCH
B:
[5-248]
------
S
Q
F
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-
G
T
A
T
S
E
S
G
A
Q
A
I
S
D
Y
--
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
-
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
--------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
--------
18
PsiBlast_PDB
50.01
36%
-2
- C1 -
-
3RRO
5
FABG_VIBCH
A:
[5-248]
------
S
Q
F
M
N
L
E
G
K
V
A
L
V
T
G
A
S
R
G
I
G
K
A
I
A
E
L
L
A
E
R
G
A
K
V
I
-
G
T
A
T
S
E
S
G
A
Q
A
I
S
D
Y
--
L
G
D
N
G
K
G
M
A
L
N
V
T
N
P
E
S
I
E
A
V
L
K
A
I
T
D
E
F
G
G
V
D
I
L
V
N
N
A
G
I
T
R
D
N
L
L
M
R
M
K
E
E
E
W
S
D
I
M
E
T
N
L
T
S
I
F
R
L
S
K
A
V
L
R
G
M
M
K
K
-
R
-
Q
G
R
I
I
N
V
G
S
V
V
G
T
M
G
N
A
G
Q
A
N
Y
A
A
A
K
A
G
V
I
G
F
T
K
S
M
A
R
E
V
A
S
R
G
V
T
V
N
T
V
A
P
G
F
I
E
T
D
M
T
K
A
L
N
D
E
Q
R
T
A
--------
T
L
A
Q
V
P
A
G
R
L
G
D
P
R
E
I
A
S
A
V
A
F
L
A
S
P
E
A
A
Y
I
T
G
E
T
L
H
V
N
G
G
M
--------