@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0C6: (2018-01-19 )
MCGIVGMIGLKNVTPGLIDGLEKLEYRGYDSAGIFVSDGTTDYLVKAQGRIQNLKNKINIDTTGNIGIGHTRWATHGQPSEENAHPHTSQSGRFVLVHNGVIENFEELKIAYLANDHFIGETDTEIIAHLIETFAKDTTTQEAFLKALRVIKGSYAFALIDRTAPDVIYVAKNKSPLLIGLGDGFNVIASDAMAMLAHTKEFVEIEDEEMVTVTSEKVIIQNFAGDIVERSSFEAQVDASDIEKGTYPFYMLKEIDEQPIIMRRIAQKYVTEDNRVSLDQKLVDTLSDSDRIYIVACGTSYHAGLAGKQTLEKLTQIPVEVHLASEFGYNTPLLSKKPFFIFLSQSGETADSRQVLVKINRLGYPSLTITNVAGSTLSREASFTLLLHAGPEIAVASTKAYTAQIAVLTLLAKAIGDKKEFETSLVFDITHELSLVANAMESVIAQKDYLEELAEVYLSDTRNAFYIGRGADYNVSLEAALKLKEISYIQAEGFAAGELKHGTIALIEEGTPVIGIISEEVTGAHTRGNLKEVESRGAKTLVIVSEGLEKESDQLVLPTVHPYLTTLTTVVPTQLLAYYATLLRGFDVDKPRNLAKSVTVE
Atome Classification :
(32 SA)
.........10........20........30........-40...-.....50........60...-......70........80........90........100.......110..-...-..120.......130.-....-..140.......150.......160.......170.......180.......190.......200.......210.......220.......230...--....240.......250.......-260.-----......270----....--.--.---...--280.---------......290.......300.......310.-......320.....-..-330.......340---.........350.......360..---.....370.......380.......390.......400.......410.......420.......430.......440.......450..-..-.-..460.......470.......480.......490.......500.......510.......520.......530........540..----..--.-----..550---......--...560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MCG
I
V
GMIGLKNV
T
P
G
L
I
D
G
L
E
K
L
EYRGYDSA
G
I
F
VSDG-TT
D
Y
L
-
V
KAQ
G
R
I
Q
N
L
KN
K
I
NI-DTT-GNIGIGHTRWATHGQPSEENAHPHTSQSG
R
F
V
L
V
H
N
G
V
IE
N
F
E
E
L
K
I
A
Y
LA-NDH-FIGET
D
T
E
I
I
A
H
L
I
E
T
-
F
AKD-T
T
T
Q
E
A
F
L
K
A
L
R
V
IKGS
Y
A
F
A
L
IDRTAP
D
V
I
Y
V
AKNKS
P
L
L
I
GLGDG
F
N
V
I
A
S
D
A
M
A
M
L
A
H
T
K
E
F
VEIEDE
E
M
V
T
VTSE
K
V
I
I
Q
N
F
A
G
D
I
V
ERSSFEA--QV
D
A
S
DIEKGTY
P
F
Y
M
L
K
EIDEQ
P
-
I
I
M
R
-----
R
I
A
Q
K
YV------TEDN--R--V---
S
L
D
--
Q
K
L
V
---------
D
TLSDSD
R
I
Y
I
V
A
CGTSYHAGLA
G
K
Q
T
L
E
K
-
L
TQI
P
V
E
V
H
L
A
S
EF-GY-NTPLLSKK
P
F
F
-----
I
F
LSQSGETADS
R
Q
V
L
V
K
I
NRLGY---P
S
L
T
I
T
NVAGSTLSREA
S
F
T
L
L
L
HAGP
E
I
A
V
A
STKA
Y
T
A
Q
I
A
V
L
T
L
L
A
K
AIG
D
K
K
E
FE
T
S
L
V
F
D
I
T
H
E
L
S
L
V
A
N
A
M
E
S
V
I
A
Q
K
D
Y
L
E
E
L
A
-
E
V
-
Y
-
L
S
DTR
N
A
F
Y
I
GRGAD
Y
N
V
S
L
E
A
A
L
K
L
K
E
I
S
Y
I
QAEGFAAGELKH
G
T
I
A
L
I
EEGT
P
V
I
G
I
ISEEVTGAHTRG
N
L
K
-
E
V
E
SRG
A
K
T
L
V
I
V----SE--G-----LEK-----ESD
Q
L
V
--
L
PTV
H
P
Y
L
T
T
L
T
T
V
V
P
T
Q
L
L
A
Y
Y
A
T
L
L
RGFDVD
K
P
R
N
L
A
K
SVTVE
6
PsiBlast_PDB
77.98
60%
-112
- C1 -
-
4S1W
2
?
A:
[5-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
-
A
V
M
R
-----
R
I
I
Q
E
Y
Q
------
D
A
E
G
--
N
--
L
---
K
I
D
--
Q
D
I
I
---------
N
D
V
K
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
-
W
A
G
V
P
T
E
V
H
V
A
S
E
F
-
V
Y
-
N
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
H
---
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
--
E
A
D
I
--
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
M
E
Q
I
A
-
T
D
-
F
-
L
E
T
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
R
G
N
V
K
-
E
V
V
A
R
G
A
H
P
C
I
I
S
----
M
E
--
G
-----
L
E
K
-----
E
G
D
T
Y
V
--
I
P
H
V
H
E
L
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
----------------
22
PsiBlast_CBE
77.72
42%
4
- C1 -
-
4AMV
2
GLMS_ECOLI
B:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
1
PsiBlast_PDB
77.70
42%
5
- C1 -
-
4AMV
1
GLMS_ECOLI
A:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
25
PsiBlast_CBE
76.79
42%
11
- C1 -
-
2J6H
3
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
21
PsiBlast_CBE
76.78
42%
7
- C1 -
-
4AMV
2
GLMS_ECOLI
C:
[2-609]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
3
PsiBlast_PDB
76.29
42%
10
- C1 -
-
2J6H
3
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
I
E
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
30
PsiBlast_CBE
75.34
42%
10
- C1 -
-
3OOJ
7
GLMS_ECOLI
D:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
------
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
29
PsiBlast_CBE
75.30
42%
11
- C1 -
-
3OOJ
2
GLMS_ECOLI
E:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
D
A
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
7
PsiBlast_PDB
75.24
42%
5
- C1 -
-
3OOJ
7
GLMS_ECOLI
A:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
N
L
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
26
PsiBlast_CBE
75.04
42%
6
- C1 -
-
3OOJ
14
GLMS_ECOLI
H:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
27
PsiBlast_CBE
74.57
42%
11
- C1 -
-
3OOJ
14
GLMS_ECOLI
G:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL---
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
31
PsiBlast_CBE
74.53
42%
9
- C1 -
-
3OOJ
7
GLMS_ECOLI
C:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
-------
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
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F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
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A
L
K
L
K
E
I
S
Y
I
H
A
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A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
I
E
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
28
PsiBlast_CBE
74.48
42%
4
- C1 -
-
3OOJ
1
GLMS_ECOLI
F:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
----------------
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
24
PsiBlast_CBE
74.43
42%
2
- C1 -
-
1JXA
1
GLMS_ECOLI
B:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
2
PsiBlast_PDB
74.36
42%
9
- C1 -
-
1JXA
1
GLMS_ECOLI
A:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
I
E
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
32
PsiBlast_CBE
73.55
42%
12
- C1 -
-
3OOJ
7
GLMS_ECOLI
B:
[1-608]
-
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
52
HHSearch
72.98
62%
-77
- C1 -
-
4S1W
1
?
B:
[3-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
Y
A
H
Y
M
L
K
E
I
H
E
Q
P
-
A
V
M
R
-----
R
I
I
Q
E
Y
Q
------
D
A
E
G
--
N
--
L
---
K
I
D
--
Q
D
I
I
---------
N
D
V
K
E
A
D
R
I
Y
V
I
A
A
G
T
S
Y
H
A
G
L
V
G
K
E
F
L
E
K
-
W
A
G
V
P
T
E
V
H
V
A
S
E
F
-
V
Y
-
N
M
P
L
L
S
E
K
P
L
F
-----
V
Y
I
S
Q
S
G
E
T
A
D
S
R
A
V
L
V
E
T
N
K
L
G
H
---
K
S
L
T
I
T
N
V
A
G
S
T
L
S
R
E
A
D
H
T
L
L
L
H
A
G
P
E
I
A
V
A
S
T
K
A
Y
T
A
Q
I
A
V
L
S
I
L
S
Q
I
V
A
K
E
H
--
E
--
A
D
I
D
L
L
R
E
L
A
K
V
T
T
A
I
E
A
I
V
D
D
A
P
I
M
E
Q
I
A
-
T
D
-
F
L
E
T
-
T
R
N
A
F
F
I
G
R
T
I
D
Y
N
V
S
L
E
G
A
L
K
L
K
E
I
S
Y
I
Q
A
E
G
F
A
G
G
E
L
K
H
G
T
I
A
L
I
E
D
G
T
P
V
V
A
L
A
T
Q
E
N
V
N
L
S
I
R
G
N
V
K
-
E
V
V
A
R
G
A
H
P
C
I
I
S
----
M
E
--
G
-----
L
E
K
-----
E
G
D
T
Y
V
--
I
P
H
V
H
E
L
L
T
P
L
V
S
V
V
A
L
Q
L
I
S
Y
Y
A
A
L
H
R
D
L
D
V
D
K
-----------
48
HHSearch
72.87
42%
-2
- C1 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
E
G
H
M
T
R
-
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
H
P
L
H
-
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
--
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
R
G
Y
T
-
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
-
E
L
K
Q
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
--
N
L
Q
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
-----
N
T
L
T
G
R
I
------
S
H
G
Q
VD
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
-
S
D
-
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
--
D
-----
A
G
F
VSSD-
N
M
H
I
I
E
--
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
23
PsiBlast_CBE
72.32
42%
4
- C1 -
-
1JXA
1
GLMS_ECOLI
C:
[1-608]
-
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
D
A
-
E
G
H
M
T
R
L
R
R
L
G
K
V
Q
M
L
A
Q
A
A
E
E
-
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
--
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
K
A
-
R
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
Q
G
-
G
T
L
R
E
A
V
L
R
A
I
P
Q
L
R
G
A
Y
G
T
V
I
M
D
S
R
H
P
D
T
L
L
A
A
R
S
G
S
P
L
V
I
G
L
G
M
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
E
G
D
I
A
E
I
T
R
R
S
V
N
I
F
D
K
T
G
A
E
V
K
R
Q
D
I
E
S
NL
Q
Y
D
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
49
HHSearch
56.20
37%
-26
- C1 -
-
2PUT
2
GFA1_CANAL
B:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
-
D
S
A
F
-----
N
T
M
R
G
R
I
------
D
F
E
N
C-
V
--
V
T
L
G
G
L
K
--
S
-
W
L
---------
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
-
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-
L
D
-
R
R
S
P
V
F
R
D
D
T
C
-----
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
---
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
-
N
S
S
L
-
N
D
-
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
K
H
G
I
L
A
L
V
D
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
-
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
--
G
-----
D
A
I
ISND
K
V
H
T
T
L
E
--
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
13
PsiBlast_PDB
55.13
39%
-23
- C1 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
-----
T
M
R
G
R
V
N
------
F
D
D
Y
--
T
--
V
---
N
L
G
GL
K
D
H
I
---------
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
-
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
L
-
Y
---
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
-
Q
V
V
A
R
Q
G
R
P
V
V
I
C
DKED
T
E
--
T
-----
I
K
N
-----
T
K
R
T
I
K
--
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
12
PsiBlast_PDB
55.10
39%
-21
- C1 -
-
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
E
S
V
V
N
-----
T
M
R
G
R
V
N
------
F
D
D
Y
--
T
--
V
---
N
L
G
GL
K
D
H
I
---------
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
-
L
T
E
L
P
V
M
V
E
L
A
S
D
F
L
D
R
-
N
T
P
V
F
R
D
D
V
C
F
------
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
T
E
L
-
Y
---
H
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
-
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
KED
T
E
--
T
-----
I
K
N
-----
T
K
R
T
I
K
--
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
55
HHSearch
51.91
41%
3
- C1 -
-
1MOQ
3
GLMS_ECOLI
A:
[4-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
-----
N
T
L
T
G
R
I
------
S
H
G
Q
V-
D
L-
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
-
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
-
S
D
-
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
--
D
-----
A
G
F
V
S
S
D-
N
M
H
I
I
E
--
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
8
PsiBlast_PDB
51.57
42%
10
- C1 -
-
1MOS
2
GLMS_ECOLI
A:
[2-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
10
PsiBlast_PDB
50.45
42%
11
- C1 -
-
1MOR
1
GLMS_ECOLI
A:
[3-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
9
PsiBlast_PDB
49.92
42%
11
- C1 -
-
1MOQ
3
GLMS_ECOLI
A:
[3-368]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
N
T
L
TG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
5
PsiBlast_PDB
49.76
42%
13
- C1 -
-
2VF5
1
GLMS_ECOLI
X:
[243-608]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
--
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
NTLTG
R
I
S
H
G
Q
V
---------
D
--
L
--
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
-
R
K
S
A
V
R
R
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L--
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
-
E
D
-
F
--
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
I
A
L
E
G
A
L
K
L
K
E
I
S
Y
I
H
A
E
A
Y
A
A
G
E
L
K
H
G
P
L
A
L
I
D
A
D
M
P
V
I
V
V
A
P
N
N
E
L
L
E
K
L
K
S
N
I
E
-
E
V
R
A
R
G
G
Q
L
Y
V
F
A
----
D
Q
DA
G
-----
F
V
S
-----
S
D
N
M
H
I
IE
M
P
H
V
E
E
V
I
A
P
I
F
Y
T
V
P
L
Q
L
L
A
Y
H
V
A
L
I
K
G
T
D
V
D
Q
P
R
N
L
A
K
S
V
T
V
E
54
HHSearch
48.54
39%
11
- C1 -
-
2ZJ4
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
-
E
S
V
V
-----
N
T
M
R
G
R
V
NFDDYT
V
N
L
G
---------
G
L
K
--
D
-
H
I
---------
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
-
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
-
R
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
-
T
E
-
L
-
Y
H
-
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
----
K
E
--
D
-----
T
E
T
I
K
N
--
T
K
R
T
I
K
--
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
53
HHSearch
47.78
39%
11
- C1 -
-
2ZJ3
1
GFPT1_HUMAN
A:
[11-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
N
F
S
S
F
M
Q
K
E
I
F
E
Q
P
-
E
S
V
V
-----
N
T
M
R
G
R
V
NFDDYT
V
N
L
G
---------
G
L
K
--
D
-
H
I
---------
K
E
I
Q
R
C
R
R
L
I
L
I
A
C
G
T
S
Y
H
A
G
V
A
T
R
Q
V
L
E
E
-
L
T
E
L
P
V
M
V
E
L
A
S
D
F
-
L
D
-
R
N
T
P
V
F
R
D
D
V
C
-----
F
F
L
S
Q
S
G
E
T
A
D
T
L
M
G
L
R
Y
C
K
E
R
G
A
---
L
T
V
G
I
T
N
T
V
G
S
S
I
S
R
E
T
D
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
F
V
S
L
V
M
F
A
L
M
M
C
D
D
R
I
S
M
Q
E
R
R
K
E
I
M
L
G
L
K
R
L
P
D
L
I
K
E
V
L
S
M
D
D
E
I
Q
K
L
A
-
T
E
-
L
-
Y
H
-
Q
K
S
V
L
I
M
G
R
G
Y
H
Y
A
T
C
L
E
G
A
L
K
I
K
E
I
T
Y
M
H
S
E
G
I
L
A
G
E
L
K
H
G
P
L
A
L
V
D
K
L
M
P
V
I
M
I
I
M
R
D
H
T
Y
A
K
C
Q
N
A
L
Q
Q
V
V
A
R
Q
G
R
P
V
V
I
C
D
----
K
E
--
D
-----
T
E
T
I
K
N
--
T
K
R
T
I
K
--
V
P
H
S
V
D
C
L
Q
G
I
L
S
V
I
P
L
Q
L
L
A
F
H
L
A
V
L
R
G
Y
D
V
D
F
P
R
N
L
A
K
S
V
T
V
E
36
PsiBlast_CBE
47.69
36%
-21
- C1 -
-
2PUW
1
GFA1_CANAL
B:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
------------
D
S
A
F
N
------
T
M
R
G
--
R
--
I
---
D
F
E
--
N
C
V
V
T
L
GGLKSW
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
-
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
---
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
-
N
S
-
S
----
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
-----------
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
-
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
--
G
D------------
V
H
T
T
L
E
--
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
18
PsiBlast_PDB
47.22
36%
-11
- C1 -
-
2PUW
2
GFA1_CANAL
A:
[4-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
F
M
Q
K
E
I
F
E
Q
P
------------
D
S
A
F
N
------
T
M
R
G
--
R
--
I
---
D
F
E
--
N
C
V
V
T
L
GGLKSW
L
S
T
I
R
R
C
R
R
I
I
M
I
A
C
G
T
S
Y
H
S
C
L
A
T
R
S
I
F
E
E
-
L
T
E
I
P
V
S
V
E
L
A
S
D
F
-------
L
D
R
R
S
P
V
F
RD
D
T
C
V
F
V
S
Q
S
G
E
T
A
D
S
I
L
A
L
Q
Y
C
L
E
R
G
A
---
L
T
V
G
I
V
N
S
V
G
S
S
M
S
R
Q
T
H
C
G
V
H
I
N
A
G
P
E
I
G
V
A
S
T
K
A
Y
T
S
Q
Y
I
A
L
V
M
F
A
L
S
L
S
N
D
S
I
S
R
K
G
R
H
E
E
I
I
K
G
L
Q
K
I
P
E
Q
I
K
Q
V
L
K
L
E
N
K
I
K
D
L
C
-
N
S
-
S
----
Q
K
S
L
L
L
L
G
R
G
Y
Q
F
A
T
A
L
E
G
A
L
K
I
K
E
I
S
Y
M
H
S
E
G
V
L
A
G
E
L
---------
E
D
L
P
I
I
A
F
A
T
R
D
S
L
F
P
K
V
M
S
A
I
E
-
Q
V
T
A
R
D
G
R
P
I
V
I
C
----
N
E
--
G
DAIIS
N
D
K
-----
V
H
T
T
L
E
--
V
P
E
T
V
D
C
L
Q
G
L
L
N
V
I
P
L
Q
L
I
S
Y
W
L
A
V
N
R
G
I
D
V
D
------------
79
Fugue
32.36
40%
-26
* C1 *
-
1MOQ
2
?
?:
[3-185]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
-
N
A
I
K
-----
N
T
L
T
G
R
I
------
S
H
G
Q
--
V
DL
S
---
E
L
G
--
P
N
A
D
---------
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
-
L
A
G
I
P
C
D
V
E
I
A
S
E
F
-
R
Y
R
K
S
A
V
R
R
-
N
S
L
M
-----
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
--GYL
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------