@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0H6: (2018-01-20 )
MILLQANQIARHFGAEVLFENIHLEISTGARVALVGRNGAGKSTLLKIIAGIEAPDEGKIAKNKTATLGYLAQDTGLDSNETVWNEMLKAFEQVRQMEERMRELEIFISEGTPDTPAYSSYLKEYDRLQHDFSDRNGYGYENEIRSVLHGFKFDSSFYDQKIDTLSGGQRTRLALARMLLQHPDILILDEPTNHLDIETLSWLENYLQSYTGALLIVSHDRYFLDKVVNEVYELSRRKMRHYKGNYSKYLDLKAEQLASEWKAYEKQQTEIHKLEDFVARNLVRASTTKRAQSRRKTLEKMDRLDRPQGDEKQANFLFSIEKPSGNVVLQIEDAAIGYDNVTLSEPINLDIRRQEAIALVGPNGIGKSTLLKSIIHQIPFIRGKETLGTNVTIGYYDQGQADLHTNKTILAELWDEHPTTPEKEIRSALGAFLFSGEDVEKPIPLLSGGEKARVALAKLAMNKENFLILDEPTNHLDIDNKEVLENALIDYDGTLLFVSHDRYFINRIATKVVELSENGSKVYLGDYDYYLEKKQEEEEIAELLAQDEPESAPAPTNKSDYYQSKEQQKLIRSLQRKITQVEEEMARIDEWIDQLEQEMVAPENLEDHVKLNELNQDLEAARQDQETKLTEWEELSLELEEYEN
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10-..-.....-..20...----.....30........40........50........60...----------..--...70......-..80........90.--.......100.....--...110...-....120.......130.......140.......150---....--------....160.......170.......180.......190......---.200.......210--..---.......220...---....230....-----...240.......250-.....--...260....-...270.......280.......290.......-300.......310-......-.320..-.....330.......340.........350.......360.......370.......380.......390......---.-400-----------.----------.-----...---------------------------.-------------------------------.410-----------------.-----------------------------------...-----------.-----------..----.420----------------------------.---........430.....-..440.......-450.......460.......470.....-..480.......490---...----.....500.......510....-..-.520.-.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640..------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
L
Q
A
N
Q
I
A
--
R
H
-
F
G
A
E
V
-
L
F
EN
I
H
L
----
E
ISTG
A
R
V
A
L
V
GRNGA
G
K
S
T
L
L
K
I
I
AGIEAPDEGKIAKNK----------T
A
--
T
L
G
Y
L
AQDTGL-DSN
E
T
V
W
N
E
M
L
K
A
F
E
--
Q
V
R
Q
M
E
E
R
M
-
R
E
L
E
I
--
F
I
SEGTPDT-
P
A
Y
S
S
Y
L
K
E
Y
D
R
L
QHDFSDRNGYG
Y
E
N
E
I
R
S
V
L
H
GF----KFDS--------
S
F
Y
DQKIDTLSGG
Q
R
T
R
L
A
L
A
R
M
L
LQHP
D
I
L
I
LDEPTNHLD
I
E
---
T
L
S
W
L
E
N
Y
L
Q
SY----T
G
---
A
L
L
I
V
SH
D
R
Y
F
L
D
---
K
V
V
N
E
V
Y
E
L
S
R
-----
R
K
M
R
H
YKGN
Y
S
K
Y
L
D
--
L
K
A
E
Q
--
L
A
S
E
W
K
A
Y
E
K
-
Q
Q
T
E
I
H
K
L
E
D
F
V
A
R
N
L
V
R
A
S
T
T
K
R
A
Q
S
R
R
K
T
L
E
-
K
M
D
RLDRPQGDEK-QA
N
F
L
F
-
S
I
EKPS-G
N
V
V
L
Q
I
EDAAIGYDN--VTLSEPI
N
L
D
I
R
R
Q
E
A
I
A
L
VGPNGI
G
K
S
T
L
L
K
S
I
I
H
QIPFIRGKETLGTN
V
T
I
G
Y
YDQ---G-QAD-----------L----------H-----T
N
K
---------------------------
T
-------------------------------
I
L
A
------------------
E
-----------------------------------
L
W
D-----------E-----------HP----TT------------------------------
P
---
E
K
E
I
R
S
A
L
G
A
F
LFSGE-DVEKPIPLLSGG-
E
K
A
R
V
A
L
A
K
L
AMNKE
N
F
L
I
LDEPTNHLD-ID
N
K
E
V
L
E
N
A
LIDY----DG
T
----
L
L
F
V
SH
D
R
Y
F
I
N
R
I
A
T
K
V
V
E
LS-EN-G
S
-
K
V
-
Y
LG
D
Y
D
Y
Y
L
E
K
KQ
E
E
E
E
I
A
E
L
L
AQDEPESAPAPTN
K
S
D
Y
Y
Q
S
K
E
Q
Q
K
L
I
R
S
L
Q
R
K
I
T
Q
V
E
E
E
M
A
R
I
D
E
W
I
D
Q
L
E
Q
E
MVAPEN
L
E
D
H
V
K
L
N
E
L
N
Q
D
L
E
A
A
RQDQETKLT
E
W
E
E
L
S
L
E
L
E
EYEN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.52
33%
-12
- C2 -
-
4FIN
6
ETTA_ECOLI
A:
[21-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
N
I
S
L
----
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
----------
D
I
--
K
I
G
Y
L
P
Q
E
P
Q
L
-
N
P
E
H
T
V
R
E
S
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
-
D
E
V
Y
A
--
L
Y
A
D
P
D
A
D
----
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
----
R
L
P
D
----------
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
---
N
V
A
G
W
I
L
E
L
D
R
-----
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
--
Q
K
D
Q
R
--
L
A
Q
E
A
S
Q
E
A
A
-
R
R
K
S
I
E
K
E
L
E
W
-----
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
-
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
-
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
T
V
K
L
A
S
V
D
Q
---
F
-
R
D
S
-----------
M
----------
D
-----
N
S
K
---------------------------
T
-------------------------------
V
---------------------------------------------------------
W
E
-----------
E
V
SGGLDIM---
K
I
----
G
N
------------------------------
T
---
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
-
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
-
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
-
D
E
-
G
K
V
E
F
-
F
E
G
N
F
T
E
Y
E
E
Y
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.79
33%
8
- C2 -
-
3J5S
-
ETTA_ECOLI
D:
[21-535]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
N
I
S
L
----
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
----------
D
I
--
K
I
G
Y
L
P
Q
E
P
Q
L
-
N
P
E
H
T
V
R
E
S
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
-
D
E
V
Y
A
--
L
Y
A
D
P
D
A
D
----
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
----
R
L
P
D
----------
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
---
N
V
A
G
W
I
L
E
L
D
R
-----
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
--
Q
K
D
Q
R
--
L
A
Q
E
A
S
Q
E
A
A
-
R
R
K
S
I
E
K
E
L
E
W
-----
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
-
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
-
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
T
V
K
L
A
S
V
D
Q
---
F
-
R
D
S
-----------
M
----------
D
-----
N
S
K
---------------------------
T
-------------------------------
V
---------------------------------------------------------
W
E
-----------
E
VSGGLDIM---
K
I
----
G
N
------------------------------
T
---
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
-
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
-
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
-
D
E
-
G
K
V
E
F
-
F
E
G
N
F
T
E
Y
E
E
Y
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
75.64
33%
49
- C2 -
-
3J5S
-
ETTA_ECOLI
D:
[9-533]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
V
G
--
K
V
V
P
P
K
R
H
-
I
L
K
N
I
S
L
----
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
G
E
A
R
P
Q
P
----------
D
I
--
K
I
G
Y
L
P
Q
E
P
Q
L
-
N
P
E
H
T
V
R
E
S
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
-
D
E
V
Y
A
--
L
Y
A
D
P
--
D
--
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
----
R
L
P
----------
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
---
N
V
A
G
W
I
L
E
L
D
R
-----
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
--
Q
K
D
Q
R
--
L
A
Q
E
A
S
Q
E
A
A
-
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
-
K
-
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
-
E
L
N
S
T
E
Y
Q
K
R
N
E
--
T
N
E
L
F
I
-
P
P
G
P
R
L
-
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
T
V
K
L
A
S
V
D
Q
---
F
-
R
D
S
-----------
M
----------
D
-----
N
S
K
---------------------------
T
-------------------------------
V
W
E
------------------
E
-----------------------------------
V
S
G
-----------
G
-----------
L
D
IMKI
G
N
------------------------------
T
---
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
-
D
Q
G
K
R
V
G
E
L
S
G
G
-
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
-
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
-
D
E
-
G
K
-
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
72.72
27%
-61
- C2 -
-
2IX8
-
A:
[1434-1972]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
--
L
A
-
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
----------
C
R
--
T
V
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
D
F
V
F
E
S
G
V
----------------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--
K
C
P
A
A
---------------
K
----------
A
Y
-----------------
E
-
E
L
S
N
T
D
L
E
F
K
F
P
--
E
P
G
Y
-
L
-
E
G
V
K
T
K
-
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
---
H
-
A
F
A
H
IESHLDKT
P
S
E
----------
Y
I
Q
W
R
F
Q
T
G
-----------------------------------------------------------
D
R
E
TMDRANRQINENDAEAMN
K
I
F
K
I
E
G
T
P
R
R
I
AGI
H
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
G
M
KSE
R
W
V
P
M
M
SV
D
-----------
N
A
----
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
ALASGQFRPL
T
---
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
-
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
-
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
-
D
G
-
R
M
-
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
71.77
27%
32
- C2 -
-
2IW3
1
EF3A_YEAST
A:
[436-978]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
-
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
D
--
G
F
P
T
Q
E
E
----------
C
R
--
T
V
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
D
F
V
F
E
S
G
V
----------------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
--
K
C
P
A
A
---------------------
K
A
Y
E
E
L
S
N
T
D
-----------------
L
E
-
F
K
F
P
E
P
G
---
Y
----
L
-
E
G
V
K
T
K
-
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
---
H
-
A
F
A
H
----------
I
ESHLDKT
P
S
E
Y
-----
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
------------------
N
-----------------------------------
I
G
M
-----------
K
S
E
R
W
V
P
M
M
SVD
N
A
----
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQFRPL
T
---
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
-
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
-
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
-
D
G
-
R
M
-
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.01
26%
-82
- C2 -
-
2IW3
1
EF3A_YEAST
A:
[445-756]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
-------------------
G
F
P
T
Q
-------------------
E
--
E
C
R
T
----------
V
--
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
--------
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
-------
K
--
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
----
E
F
---
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
K
A
I
V
-
K
V
T
N
M
E
----------------
F
Q
Y
P
--
G
T
S
K
P
Q
I
T
D
---------------
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
-
H
I
E
-----------
S
----------
H
-----
L
D
K
---------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.84
26%
-89
- C2 -
-
2IWH
1
EF3A_YEAST
A:
[445-756]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
-------------------
G
F
P
T
Q
-------------------
E
--
E
C
R
T
----------
V
--
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
--------
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
-------
K
--
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
----
E
F
---
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
K
A
I
V
-
K
V
T
N
M
E
-----------
F
Q
Y
P
G
T
S
K
P
-------
Q
I
T
D
---------------
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
-
H
I
E
-----------
S
----------
H
-----
L
D
K
---------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.67
26%
-85
- C2 -
-
2IX3
-
EF3A_YEAST
A:
[445-756]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
-------------------
G
F
P
T
Q
-------------------
E
--
E
C
R
T
----------
V
--
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
--------
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
-------
K
--
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
----
E
F
---
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
K
A
I
V
-
K
V
T
N
M
E
-----------
F
Q
Y
P
G
T
S
K
P
-------
Q
I
T
D
---------------
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
-
H
I
E
-----------
S
----------
H
-----
L
D
K
---------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
60.44
26%
-78
- C2 -
-
2IX8
-
A:
[1439-1751]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
K
I
-
L
L
N
K
T
Q
L
----
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
------
N
G
Q
V
D
-------------------
G
F
P
T
Q
-------------------
E
--
E
C
R
T
----------
V
--
Y
V
E
H
D
I
D
G
T
-
H
S
D
T
S
V
L
--------
D
F
V
F
E
S
G
V
G
T
K
E
A
I
K
D
K
L
I
E
F
----
G
F
T
D
--------
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
---
N
V
C
E
Y
I
I
N
Y
E
G
-----
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
-------
K
--
K
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
----
E
F
---
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
K
A
I
V
-
K
V
T
N
M
E
-----------
F
Q
Y
------
P
-
G
T
S
K
P
Q
I
T
D
---------------
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
N
C
R
I
A
Y
I
K
Q
H
A
F
A
-
H
I
E
-----------
S
----------
H
-----
L
D
K
---------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.70
24%
34
- C2 -
-
3BK7
2
?
A:
[114-543]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
--------------------------
L
C
E
D
N
---
D
S
----
W
D
N
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
-
K
N
G
E
I
-------
R
P
V
V
K
P
Q
Y
V
D
L
L
P
K
--------------
A
V
K
G
K
V
R
E
L
L
K
K
V
DEVG
K
F
E
E
V
V
K
E
L
ELE
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
GY
L
K
D
E
N
--
V
--
R
F
R
P
Y
E
I
-
R
F
T
K
L
----------------
S
E
R
V
D
V
E
R
E
T
L
V
-
E
Y
P
R
L
V
K
D
Y
G
S
--------
F
-
K
L
E
V
E
P
-
G
--------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
--
V
E
W
D
L
T
V
A
Y
K
P
Q
---
Y
I
K
A
E
-----------
Y
----------
E
-----
G
T
V
---------------------------
Y
-------------------------------
E
L
L
------------------
S
-----------------------------------
K
I
D
-----------
S
-----------
S
K
----
L
N
------------------------------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-
N
V
E
D
----
L
S
G
G
-
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
-
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
59.32
18%
50
- C2 -
-
3J16
3
RLI1_YEAST
B:
[1-608]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPFDA
I
Q
I
I
N
L
P
T
N
L
E
--
A
H
-
V
T
H
R
Y
-
S
A
N
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
-------------------------------
F
D
D
P
P
E
W
Q
E
I
I
K
Y
F
R
GS
E
L
Q
N
Y
F
T
K
M
-
L
E
D
D
I
--
K
A
I
I
K
P
Q
Y
V
-
D
N
I
P
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
----
Q
L
E
---------
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
---
Y
L
S
D
F
V
C
I
I
Y
G
-----
V
P
------------------------
S
V
Y
G
V
V
T
L
-
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
-
D
A
T
E
D
L
Q
N
D
S
A
S
R
-
A
F
S
Y
P
--
S
L
K
K
T
Q
-
G
D
F
V
L
N
V
E
E
G
E
F
-----------------
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
--
P
D
E
G
Q
D
I
P
K
L
N
V
S
M
K
P
Q
---
K
-
I
A
P
-----------
K
----------
F
-----
P
G
T
---------------------------
V
-------------------------------
R
Q
L
------------------
F
-----------------------------------
F
K
K
-----------
I
-----------
R
G
----
Q
F
------------------------------
L
---
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-
I
I
D
Q
E
V
Q
H
L
S
G
G
-
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
-
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
P
-
S
K
-
N
A
-
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.09
24%
31
- C2 -
-
3J15
2
?
B:
[100-529]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
--------------------------
L
C
E
D
N
---
D
S
----
W
D
N
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
-
K
N
G
E
I
-------
R
P
V
V
K
P
Q
Y
V
D
L
L
P
K
--------------
A
V
K
G
K
V
R
E
L
L
K
K
V
DEVG
K
F
E
E
V
V
K
E
L
ELE
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
LS
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
GY
L
K
D
E
N
--
V
--
R
F
R
P
Y
E
I
-
R
F
T
K
L
----------------
S
E
R
V
D
V
E
R
E
T
L
V
-
E
Y
P
R
L
V
K
D
Y
G
S
--------
F
-
K
L
E
V
E
P
-
G
--------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
--
V
E
W
D
L
T
V
A
Y
K
P
Q
---
Y
I
K
A
E
-----------
Y
----------
E
-----
G
T
V
---------------------------
Y
-------------------------------
E
L
L
------------------
S
-----------------------------------
K
I
D
-----------
S
-----------
S
K
----
L
N
------------------------------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-
N
V
E
D
----
L
S
G
G
-
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
-
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.99
24%
31
- C2 -
-
5LW7
-
?
B:
[100-529]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
--------------------------
L
C
E
D
N
---
D
S
----
W
D
N
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
R
L
-
K
N
G
E
I
-------
R
P
V
V
K
P
Q
Y
V
D
L
L
P
K
--------------
A
V
K
G
K
V
R
E
L
L
K
K
V
DEVG
K
F
E
E
VVKELELE
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
QRL
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
YLS
D
V
I
H
V
V
Y
G
E
P
G
VYGIF
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
GY
L
K
D
E
N
--
V
--
R
F
R
P
Y
E
I
-
R
F
T
K
L
----------------
S
E
R
V
D
V
E
R
E
T
L
V
-
E
Y
P
R
L
V
K
D
Y
G
S
--------
F
-
K
L
E
V
E
P
-
G
--------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
--
V
E
W
D
L
T
V
A
Y
K
P
Q
---
Y
I
K
A
E
-----------
Y
----------
E
-----
G
T
V
---------------------------
Y
-------------------------------
E
L
L
------------------
S
-----------------------------------
K
I
D
-----------
S
-----------
S
K
----
L
N
------------------------------
S
NFY
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-
N
V
E
D
----
L
S
G
G
-
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
-
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
MEKN
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.67
23%
27
- C2 -
-
1YQT
2
?
A:
[44-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
--------------------------------
L
-
C
G
D
N
D
S
W
D
G
V
I
R
A
F
R
GN
E
L
Q
N
Y
F
E
K
L
-
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
L
-
I
P
K
A
V
K
G
K
V
I
E
L
L
K
K
--
A
D
E
T
G
-----
K
L
E
E
V
V
K
A
L
----
E
L
E
N
--------
V
L
-
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
----
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
-------------
G
E
P
G
V
Y
G
I
F
S
Q
--
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
-
D
E
N
V
-----
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
-
T
Y
P
R
L
V
K
D
Y
G
S
--------
F
-
R
L
E
V
E
P
-
G
--------------------------
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
--
I
E
W
D
L
T
V
A
Y
K
P
Q
---
Y
I
K
A
D
-----------
Y
----------
E
-----
G
T
V
---------------------------
Y
-------------------------------
E
L
L
------------------
S
-----------------------------------
K
I
D
-----------
A
-----------
S
K
----
L
N
------------------------------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
Y
D
R
-
E
V
N
E
----
L
S
G
G
-
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
-
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Fugue
50.52
20%
32
- C1 -
-
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
--
Y
P
-
S
R
P
D
V
P
I
L
R
G
M
N
L
----
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
------------------------
G
V
-
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
--
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
--
N
I
S
L
G
K
E
G
I
-
T
--------
R
E
E
M
V
A
A
C
K
M
A
N
A
---
E
K
F
I
K
T
L
P
N
G
Y
----
N
-----------
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
---
S
E
G
I
V
Q
Q
A
L
D
K
A
----
A
K
G
R
-
T
T
I
I
I
A
H
R
---
L
S
---
T
I
R
N
A
D
L
I
I
S
C
-----
K
N
G
Q
V
V
E
V
G
--
D
H
R
A
--
L
M
A
Q
Q
------------------
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G
E
R
I
G
K
D
-
A
L
S
R
L
K
Q
E
L
E
E
---------------------------------------------------------
N
N
A
Q
K
T
N
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
---
P
-
T
Y
S
-----------
V
----------
F
-------
F
---------------------------
T
-------------------------------
S
F
M
------------------
N
-----------------------------------
V
F
A
-----------
G
-----------
N
P
----
A
D
------------------------------
F
---
L
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
-
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
H
I
G
F
F
D
S
P
Q
N
A
S
G
K
I
S
T
R
L
A
T
----
D
V
P
----
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
-
G
I
-
G
L
-
A
F
-
F
Y
G
------------
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
--
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
51
HHSearch
49.82
18%
21
- C2 -
-
4CRM
2
RLI1_YEAST
P:
[99-561]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
G
R
F
D
D
P
P
----------
E
W
QE
I
I
K
Y
F
R
G
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
--
P
-
Q
-
Y
V
D
N
I
-
P
R
A
----------------
I
K
G
P
V
Q
K
V
G
E
L
---
L
-
K
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
----
Q
L
E
N
---------
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
LAP-
T
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
---
Y
L
S
D
F
V
C
I
I
Y
G
-----
V
P
S
V
Y
G
V
V
T
L
P
A
S
V
R
----
E
-
G
--
I
------------------
N
I
F
L
D
G
H
I
----
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
-
A
T
E
D
----------
L
-
Q
--
N
D
S
-
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
-
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
--
L
N
V
S
M
K
P
Q
---
K
-
I
A
------------
P
----------
K
-----
F
P
G
---------------------------
T
-------------------------------
V
R
Q
------------------
L
-----------------------------------
F
F
K
-----------
K
-----------
I
R
GQ--
F
L
------------------------------
N
---
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
--
I
I
D
Q
E
V
Q
H
L
S
G
G
-
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
-
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
ILHN
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
-
G
I
P
S
K
-
N
A
-
H
A
R
A
P
E
S
L
L
T
G
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
48.73
24%
-19
- C2 -
-
4YER
2
?
A:
[4-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
I
V
V
E
N
L
V
--
K
K
-
F
G
D
F
E
-
A
V
K
G
V
S
F
----
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
HDVLKE
P
R
E
V
R
R
--
K
I
G
I
V
F
Q
D
Q
S
L
-
D
R
E
L
T
A
Y
E
N
M
Y
I
H
G
K
--
I
Y
G
Y
-------------------------------------------
G
G
E
K
L
K
K
R
I
L
E
L
L
E
F
V
----
E
L
L
E
---------
F
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
---
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
EH
N
M
---
T
I
F
L
T
T
H
Y
M
D
E
A
E
---
Q
L
A
D
R
V
A
I
I
D
H
-----
G
K
I
I
-
A
L
G
T
P
T
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
48.21
26%
-18
- C2 -
-
3RLF
2
MALK_ECOLI
A:
[2-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
--
K
A
-
W
G
E
V
V
-
V
S
K
D
I
N
L
----
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
KRMNDTPPA-
E
R
--
G
V
G
M
V
F
Q
S
Y
A
L
-
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
--
L
A
G
A
K
-------------------------------------------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
----
Q
L
A
H
---------
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
---
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
---
T
L
A
D
K
I
V
V
L
D
A
-----
G
R
V
A
Q
-
V
G
K
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
48.02
21%
27
- C2 -
-
1YQT
2
?
A:
[24-480]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
C
V
--
H
R
-
Y
G
V
N
A
-
F
V
L
Y
R
L
P
----
V
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
C
G
D
N
D
S
W
D
---------
G
V
--
I
R
A
F
R
G
N
E
L
Q
------
N
Y
F
E
K
L
K
N
G
E
I
--
R
P
V
V
-
K
P
Q
Y
-
V
D
L
I
-----
P
----
K
---
A
---
V
K
G
---
K
V
I
E
L
L
---
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
----
E
L
E
N
---------
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
---
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
---
Y
L
S
D
I
-
I
H
V
V
Y
-----
G
E
P
G
V
Y
-
G
I
F
S
Q
-----
P
K
G
T
R
--
N
-----
G
I
-----
N
E
F
L
-
R
G
Y
L
K
D
E
N
V
R
F
-
R
------
P
Y
E
I
K
F
T
-
K
T
G
----
E
--------
R
V
------
E
I
E
-
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
---
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
--
L
T
V
A
Y
K
P
Q
---
Y
-
I
K
------------
A
----------
D
-----
Y
E
G
---------------------------
T
-------------------------------
V
Y
E
------------------
L
-----------------------------------
L
S
K
-----------
I
-----------
D
A
S
K
--
L
N
------------------------------
S
---
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
--
L
Y
D
R
E
V
N
E
L
S
G
G
-
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
-
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
-
G
E
-
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
46.73
26%
-18
* C2 *
-
2AWN
1
MALK_ECOLI
B:
[2-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
--
K
A
-
W
G
E
V
V
-
V
S
K
D
I
N
L
----
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
KRMNDTPPA-
E
R
--
G
V
G
M
V
F
Q
S
Y
A
L
-
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
--
L
A
G
A
K
-------------------------------------------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
----
Q
L
A
H
---------
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
---
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
---
T
L
A
D
K
I
V
V
L
D
A
-----
G
R
V
A
Q
-
V
G
K
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------